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https://www.readbyqxmd.com/read/28100612/sex-dependent-intestinal-replication-of-an-enteric-virus
#1
Christopher M Robinson, Yao Wang, Julie K Pfeiffer
: Coxsackievirus is an enteric virus that initiates infection in the gastrointestinal tract before disseminating to peripheral tissues to cause disease, but intestinal factors that influence viral replication are understudied. Furthermore, a sex bias for severe sequelae from coxsackievirus infections has been observed in humans. While mouse models mimicking human pathogenesis have been well characterized, many of these experiments use intraperitoneal injection of coxsackievirus to infect mice, bypassing the intestine...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28095748/myocardial-inactivation-of-thyroid-hormones-in-patients-with-aortic-stenosis
#2
Bruno Paolino, Pablo Maria Pomerantzeff, Luiz Alberto O Dallan, Fabio Antonio Gaiotto, Nailliw Zanini Preite, Ana Claudia Latronico, Jose Carlos Nicolau, Antonio Carlos Bianco, Roberto Giraldez
OBJECTIVE: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. CONTEXT: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 deiodinase (D3) has been found in a rat model of right ventricular hypertrophy. It is not known whether the human myocardium metabolizes thyroid hormone...
January 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#3
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28077532/modern-hydroxyethyl-starch-and-acute-kidney-injury-after-cardiac-surgery-a-prospective-multicentre-cohort
#4
M Vives, R Callejas, P Duque, G Echarri, D N Wijeysundera, A Hernandez, A Sabate, M Bes-Rastrollo, P Monedero
BACKGROUND: Recent trials have shown hydroxyethyl starch (HES) solutions increase the risk of acute kidney injury (AKI) in critically ill patients. It is uncertain whether these adverse effects also affect surgical patients. We sought to determine the renal safety of modern tetrastarch (6% HES 130/0.4) use in cardiac surgical patients. METHODS: In this multicentre prospective cohort study, 1058 consecutive patients who underwent cardiac surgery from 15th September 2012 to 15th December 2012 were recruited in 23 Spanish hospitals...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28073571/early-clinical-outcomes-of-a-novel-self-expanding-transapical-transcatheter-aortic-valve-bioprosthesis
#5
Michael W A Chu, Rodrigo Bagur, Katie L Losenno, Philip M Jones, Pantelis Diamantouros, Patrick Teefy, Jill J Gelinas, Bob Kiaii
OBJECTIVE: Coronary obstruction remains a challenging complication of transcatheter aortic valve replacement; however, a new self-expanding transapical prosthesis may reduce this risk. The purpose of this study was to evaluate the early 1-year outcomes of patients with low coronary heights who received the Acurate TA bioprosthesis (Symetis, Ecublens, Switzerland). METHODS: Between May 2014 and April 2015, 30 consecutive patients (aged 85 ± 6 years, 63% were female, Society of Thoracic Surgeons score 8...
December 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28043929/using-the-hyperinsulinemic-euglycemic-clamp-to-assess-insulin-sensitivity-at-3%C3%A2-months-following-roux-en-y-gastric-bypass-surgery-in-type-2-diabetes-patients-with-bmi-35%C3%A2-kg-m-2-in-china
#6
Lei Zhao, Liyong Zhu, Zhihong Su, Yong Liu, Pengzhou Li, Xiangwu Yang, Weizheng Li, Lingjie Tan, Xulong Sun, Shaihong Zhu
BACKGROUND: The aim of this study was to describe short-time effect of Roux-en-Y gastric bypass (RYGB) on insulin sensitivity (IS) of Chinese diabetes patients with body mass index (BMI) <35 kg/m(2) by hyperinsulinemic euglycemic clamp. MATERIALS AND METHODS: We studied 15 type 2 diabete mellitus (T2DM) patients with BMI <35 kg/m(2), who underwent laparoscopical Roux-en-Y gastric bypass (LRYGB). Hyperinsulinemic-euglycemic clamp were performed at baseline and at 3 months after LRYGB...
December 30, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28043451/transapical-cannulation-through-a-transcatheter-aortic-valve-implantation-valve-a-novel-approach-for-cardiogenic-collapse
#7
Louis Philippe Tremblay, Claudia Cote, Marc P Pelletier
We report a case of rescue bypass cannulation of the ventricular apex during a transapical transcatheter aortic valve implantation procedure in a patient with peripheral vascular disease not amenable to peripheral cannulation. Following rapid pacing and deployment of the transcatheter valve, cardiac function did not recover. The arterial cannula was inserted through the left ventricular apex, at the site of the transapical sheath, and advanced across the prosthetic valve, allowing for rapid initiation of cardiopulmonary bypass...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28041708/expressions-of-adenosine-a2a-receptors-in-coronary-arteries-and-peripheral-blood-mononuclear-cells-are-correlated-in-coronary-artery-disease-patients
#8
Vlad Gariboldi, Donato Vairo, Régis Guieu, Marion Marlingue, Eléonore Ravis, David Lagier, Alissa Mari, Elsa Thery, Frédéric Collart, Marine Gaudry, Laurent Bonello, Franck Paganelli, Jocelyne Condo, Nathalie Kipson, Emmanuel Fenouillet, Jean Ruf, Giovanna Mottola
BACKGROUND: Altered coronary blood flow occurs in patients with coronary artery disease (CAD). Adenosine strongly impacts blood flow mostly via adenosine A2A receptor (A2AR) expressed in coronary tissues. As part of a systemic regulation of the adenosinergic system, we compared A2AR expression in situ, and on peripheral blood mononuclear cells (PBMC) in CAD patients. METHODS AND RESULTS: Aortic and coronary tissues, and PBMC were sampled in 20 CAD patients undergoing coronary artery bypass surgery and consecutively included...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28031670/femoropopliteal-bypass-with-varicose-greater-saphenous-vein
#9
Yun Su Mun, Byung Sun Cho, Je-Ho Jang, Moon-Soo Lee, Oh Sang Kwon
Surgical bypass for peripheral arterial occlusive disease can be performed using different graft materials. Autogenous greater saphenous vein (GSV) is the treatment of choice because of its superior long-term patency. We report a case of femoropopliteal bypass with varicose GSV in a 77-year-old man who was presented with limb ischemia and both varicose veins. We successfully performed bypass with varicose vein. He has been doing well for 15 months after the operation, and a computed tomography angiography of the lower leg, performed on the 15th postoperative month, demonstrated widely patent femoropopliteal bypass graft and no structural change...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28031149/diagnostic-and-prognostic-value-of-a-careful-symptom-evaluation-and-high-sensitive-troponin-in-patients-with-suspected-stable-angina-pectoris-without-prior-cardiovascular-disease
#10
Debbie M Madsen, Axel C P Diederichsen, Susanne E Hosbond, Oke Gerke, Hans Mickley
BACKGROUND AND AIMS: Typical angina pectoris (AP) and high-sensitive troponin I (hs-TnI) are independently associated with coronary artery disease (CAD) and future cardiovascular events (CVE). This study aimed to assess the individual and combined diagnostic and prognostic impact of symptoms and hs-TnI in stable chest pain patients without prior cardiovascular disease. METHODS: During a one-year period, 487 patients with suspected stable AP underwent invasive or CT-coronary angiography (significant stenosis ≥50%)...
November 28, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28017338/complications-associated-with-femoral-cannulation-during-minimally-invasive-cardiac-surgery
#11
Joseph Lamelas, Roy F Williams, Maurice Mawad, Angelo LaPietra
BACKGROUND: Different types of cannulation techniques are available for minimally invasive cardiac surgery. At our institution, we favor a femoral platform for most minimally invasive cardiac procedures. Here, we review our results utilizing this cannulation approach. METHODS: We retrospectively reviewed all minimally invasive valve surgeries that were performed at our institution between January 2009 and January 2015. Operative times, lengths of stay, postoperative complications, and mortality were analyzed...
December 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28012643/reoperation-for-coronary-artery-bypass-grafting-surgery-outcomes-and-considerations-for-expanding-interventional-procedures
#12
Simon Maltais, Robert J Widmer, Malcolm R Bell, Richard C Daly, Joseph A Dearani, Kevin L Greason, David L Joyce, Lyle D Joyce, Hartzell V Schaff, John M Stulak
BACKGROUND: Owing to an inevitable degeneration of grafts over time, patients may require consideration for repeat coronary artery bypass graft (CABG) surgery. As our understanding of preoperative risks associated with redo CABG surgery is limited and availability of data is limited to historical cohorts, we sought to evaluate our contemporary 20-year experience with this challenging patient population. METHODS: Between January 1993 and June 2014, 748 patients underwent redo CABG surgery at our institution...
December 21, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28007264/femorofemoral-shunt-during-surgery-for-acute-debakey-type-1-dissection-to-treat-peripheral-extremity-malperfusion
#13
Eric I Jeng, Igor Voskresensky, Adam W Beck, Teng C Lee
Peripheral extremity ischemia in patients presenting with a DeBakey type 1 aortic dissection is an independent predictor for mortality. We present a patient with a DeBakey type 1 aortic dissection and peripheral extremity malperfusion that underwent simultaneous aortic repair and percutaneous femorofemoral shunt with arterial sidearm. Our approach allows for immediate peripheral extremity reperfusion and subsequent objective determination of the necessity of femorofemoral bypass via perfusion pressures.
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28004266/long-term-major-adverse-cardiac-and-cerebrovascular-events-macce-rate-comparison-of-retrograde-and-antegrade-recanalization-of-chronic-total-coronary-occlusions
#14
Klaudija Bijuklic, Carsten Schwencke, Joachim Schofer
BACKGROUND: The recanalization success rate of chronic total occlusion (CTO) percutaneous coronary interventions (PCI) can be increased by the retrograde approach; however, the long-term outcome of patients undergoing retrograde procedures is unknown. AIM: We aimed to evaluate the long-term major adverse cardiac and cerebrovascular event (MACCE) rate (e.g. death, myocardial infarction, coronary artery bypass surgery and stroke) in patients after retrograde versus antegrade CTO-PCI...
December 21, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27999040/population-pharmacokinetics-of-cefazolin-before-during-and-after-cardiopulmonary-bypass-to-optimize-dosing-regimens-for-children-undergoing-cardiac-surgery
#15
Pieter A J G De Cock, Hussain Mulla, Sarah Desmet, Filip De Somer, Brett C McWhinney, Jacobus P J Ungerer, Annelies Moerman, Sabrina Commeyne, Johan Vande Walle, Katrien Francois, Johan G C Van Hasselt, Peter De Paepe
OBJECTIVES: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. PATIENTS AND METHODS: This study included children who received cefazolin before surgical incision, before cessation of CPB and after surgery. Blood samples of total and unbound cefazolin concentrations were collected before, during and after CPB. The cefazolin concentration-time profiles were analysed using population pharmacokinetic modelling and predictors for interindividual variability in pharmacokinetic parameters were investigated...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27998608/a-score-to-estimate-30-day-mortality-after-intensive-care-admission-after-cardiac-surgery
#16
Yoan Lamarche, Mahsa Elmi-Sarabi, Lillian Ding, James G Abel, Demetrios Sirounis, André Y Denault
OBJECTIVE: Several risk-scoring systems have been developed to predict surgical mortality and complications in cardiac surgical patients, but none of the current systems include factors related to the intraoperative period. The purpose of this study was to develop a score that incorporates both preoperative and intraoperative factors so that it could be used for patients admitted to a cardiac surgical intensive care unit (ICU) immediately after surgery. METHOD: Preoperative and intraoperative data from 30,350 patients in four hospitals were used to build a multiple logistic regression model estimating 30-day mortality after cardiac surgery...
November 23, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27997747/dynamics-of-the-sealing-zone-in-cultured-osteoclasts
#17
Sarit Batsir, Benjamin Geiger, Zvi Kam
Bone resorption by osteoclasts depends on the formation and stability of the sealing zone (SZ), a peripheral belt of actin and integrin-based podosomes. Recent studies demonstrated that the SZ is a highly dynamic structure, undergoing cycles of assembly and disassembly. In this study, we explored the mechanisms underlying the regulation of SZ stability and reorganization in osteoclasts cultured on glass slides, and forming an SZ-like podosome belt (SZL). By monitoring this belt in cultured RAW264.7 cells expressing GFP-tagged actin, we show here that SZL stability is usually locally regulated, and its dissociation, occurring mostly in concave segments, is manifested in the loss of both podosome coherence, and actin belt continuity...
December 20, 2016: Cytoskeleton
https://www.readbyqxmd.com/read/27994147/ownership-of-an-artificial-limb-induced-by-electrical-brain-stimulation
#18
Kelly L Collins, Arvid Guterstam, Jeneva Cronin, Jared D Olson, H Henrik Ehrsson, Jeffrey G Ojemann
Replacing the function of a missing or paralyzed limb with a prosthetic device that acts and feels like one's own limb is a major goal in applied neuroscience. Recent studies in nonhuman primates have shown that motor control and sensory feedback can be achieved by connecting sensors in a robotic arm to electrodes implanted in the brain. However, it remains unknown whether electrical brain stimulation can be used to create a sense of ownership of an artificial limb. In this study on two human subjects, we show that ownership of an artificial hand can be induced via the electrical stimulation of the hand section of the somatosensory (SI) cortex in synchrony with touches applied to a rubber hand...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27974697/surrogate-in-vitro-activation-of-innate-immunity-synergizes-with-interleukin-7-to-unleash-rapid-antigen-driven-outgrowth-of-cd4-and-cd8-human-peripheral-blood-t-cells-naturally-recognizing-muc1-her2-neu-and-other-tumor-associated-antigens
#19
Latha B Pathangey, Dustin B McCurry, Sandra J Gendler, Ana L Dominguez, Jessica E Gorman, Girish Pathangey, Laurie A Mihalik, Yushe Dang, Mary L Disis, Peter A Cohen
Effective adoptive immunotherapy has proved elusive for many types of human cancer, often due to difficulties achieving robust expansion of natural tumor-specific T-cells from peripheral blood. We hypothesized that antigen-driven T-cell expansion might best be triggered in vitro by acute activation of innate immunity to mimic a life-threatening infection. Unfractionated peripheral blood mononuclear cells (PBMC) were subjected to a two-step culture, first synchronizing their exposure to exogenous antigens with aggressive surrogate activation of innate immunity, followed by γ-chain cytokine-modulated T-cell hyperexpansion...
December 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27974451/muscle-afferent-excitability-testing-in-spinal-root-intact-rats-dissociating-peripheral-afferent-and-efferent-volleys-generated-by-intraspinal-microstimulation
#20
Saeka Tomatsu, Geehee Kim, Joachim Confais, Kazuhiko Seki
Presynaptic inhibition of the sensory input from the periphery to the spinal cord can be evaluated directly by intra-axonal recording of primary afferent depolarization (PAD) or indirectly by intraspinal microstimulation (excitability testing). Excitability testing is superior for use in normal behaving animals, as this methodology bypasses the technically challenging intra-axonal recording. However, use of excitability testing on the muscle or joint afferent in intact animals presents its own technical challenges...
December 14, 2016: Journal of Neurophysiology
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