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5-CSRTT

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https://www.readbyqxmd.com/read/27824354/serotonergic-modulation-of-waiting-impulsivity-is-mediated-by-the-impulsivity-phenotype-in-humans
#1
S Neufang, A Akhrif, C G Herrmann, C Drepper, G A Homola, J Nowak, J Waider, A G Schmitt, K-P Lesch, M Romanos
In rodents, the five-choice serial reaction time task (5-CSRTT) has been established as a reliable measure of waiting impulsivity being defined as the ability to regulate a response in anticipation of reinforcement. Key brain structures are the nucleus accumbens (NAcc) and prefrontal regions (for example, pre- and infralimbic cortex), which are, together with other transmitters, modulated by serotonin. In this functional magnetic resonance imaging study, we examined 103 healthy males while performing the 5-CSRTT measuring brain activation in humans by means of a paradigm that has been widely applied in rodents...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27815417/dopamine-d1-and-d3-receptors-modulate-heroin-induced-cognitive-impairment-through-opponent-actions-in-mice
#2
Yongsheng Zhu, Yunpeng Wang, Jianghua Lai, Shuguang Wei, Hongbo Zhang, Peng Yan, Yunxiao Li, Xiaomeng Qiao, Fangyuan Yin
BACKGROUND: Chronic abuse of heroin leads to long-lasting and complicated cognitive impairment. Dopamine receptors are critically involved in the impulsive drug-driven behaviour and the altered attention, processing speed and mental flexibility that are associated with higher relapse rates. However, the effects of the different dopamine receptors and their possible involvement in heroin-induced cognitive impairment remain unclear. METHODS: The 5-choice serial reaction time task (5-CSRTT) was used to investigate the profiles of heroin-induced cognitive impairment in mice...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27774567/mice-haploinsufficient-for-map2k7-a-gene-involved-in-neurodevelopment-and-risk-for-schizophrenia-show-impaired-attention-a-vigilance-decrement-deficit-and-unstable-cognitive-processing-in-an-attentional-task-impact-of-minocycline
#3
R L Openshaw, D M Thomson, J M Penninger, J A Pratt, B J Morris
RATIONALE: Members of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear. OBJECTIVE: In the current study, we test the hypothesis that reduced MKK7 expression is sufficient to cause cognitive impairment. METHODS: Attentional function in mice haploinsufficient for Map2k7 (Map2k7 (+/-) mice) was investigated using the five-choice serial reaction time task (5-CSRTT)...
October 24, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27748741/chemogenetic-activation-of-midbrain-dopamine-neurons-affects-attention-but-not-impulsivity-in-the-five-choice-serial-reaction-time-task-in-rats
#4
Linde Boekhoudt, Elisa S Voets, Jacques P Flores-Dourojeanni, Mieneke Cm Luijendijk, Louk Jmj Vanderschuren, Roger Ah Adan
Attentional impairments and exaggerated impulsivity are key features of psychiatric disorders, such as attention-deficit/hyperactivity disorder, schizophrenia, and addiction. These deficits in attentional performance and impulsive behaviors have been associated with aberrant dopamine (DA) signaling, but it remains unknown whether these deficits result from enhanced DA neuronal activity in the midbrain. Here, we took a novel approach by testing the impact of chemogenetically activating DA neurons in the ventral tegmental area (VTA) or substantia nigra pars compacta (SNc) on attention and impulsivity in the five-choice serial reaction time task (5-CSRTT) in rats...
November 16, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27534540/premature-responses-in-the-five-choice-serial-reaction-time-task-reflect-rodents-temporal-strategies-evidence-from-no-light-and-pharmacological-challenges
#5
Zackary A Cope, Adam L Halberstadt, Jordy van Enkhuizen, Aaron D Flynn, Michelle Breier, Neal R Swerdlow, Mark A Geyer, Jared W Young
RATIONALE: The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while responding prematurely before a light appears is suggested to reflect impulsivity/response disinhibition. Comparison of rat and mouse 5-CSRTT performance has raised questions on the validity of premature responses as measuring impulsivity/response inhibition...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27384154/early-postnatal-manganese-exposure-causes-lasting-impairment-of-selective-and-focused-attention-and-arousal-regulation-in-adult-rats
#6
Stephane A Beaudin, Barbara J Strupp, Myla Strawderman, Donald R Smith
BACKGROUND: Studies in children and adolescents have associated early developmental manganese (Mn) exposure with inattention, impulsivity, hyperactivity, and oppositional behaviors, but causal inferences are precluded by the correlational nature of the data and generally limited control for potential confounders. OBJECTIVES: To determine whether early postnatal oral Mn exposure causes lasting attentional and impulse control deficits in adulthood, and whether continued lifelong Mn exposure exacerbates these effects, using a rat model of environmental Mn exposure...
July 6, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27265297/improvements-and-important-considerations-for-the-5-choice-serial-reaction-time-task-an-effective-measurement-of-visual-attention-in-rats
#7
Jayant Bhandari, Ritesh Daya, Ram K Mishra
BACKGROUND: The 5-choice serial reaction time task (5-CSRTT) is an automated operant conditioning task that measures rodent attention. The task allows the measurement of several parameters such as response accuracy, speed of processing, motivation, and impulsivity. The task has been widely used to investigate attentional processes in rodents for attention deficit and hyperactivity disorder and has expanded to other illnesses such as Alzheimer's disease, depression, and schizophrenia. NEW METHOD: The 5-CSRTT is accompanied with two significant caveats: a time intensive training period and largely varied individual rat capability to learn and perform the task...
September 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27241709/lorcaserin-and-cp-809101-reduce-motor-impulsivity-and-reinstatement-of-food-seeking-behavior-in-male-rats-implications-for-understanding-the-anti-obesity-property-of-5-ht2c-receptor-agonists
#8
Guy A Higgins, Leo B Silenieks, Everett B Altherr, Cam MacMillan, Paul J Fletcher, Wayne E Pratt
RATIONALE: The 5-HT2C receptor agonist lorcaserin (Belviq®) has been approved by the FDA for the treatment of obesity. Impulsivity is a contributory feature of some eating disorders. OBJECTIVE: Experiments investigated the effect of lorcaserin and the highly selective 5-HT2C agonist CP-809101 on measures of impulsivity and on reinstatement of food-seeking behaviour, a model of dietary relapse. The effect of both drugs on 22-h deprivation-induced feeding was also examined, as was the effect of prefeeding in each impulsivity test...
July 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27180168/enhanced-attention-and-impulsive-action-following-nmda-receptor-glun2b-selective-antagonist-pretreatment
#9
Guy A Higgins, Leo B Silenieks, Cam MacMillan, Julia Sevo, Fiona D Zeeb, Sandy Thevarkunnel
NMDA GluN2B (NR2B) subtype selective antagonists are currently in clinical development for a variety of indications, including major depression. We previously reported the selective NMDA GluN2B antagonists Ro 63-1908 and traxoprodil, increase premature responding in a 5-choice serial reaction time task (5-CSRTT) suggesting an effect on impulsive action. The present studies extend these investigations to a Go-NoGo and delay discounting task, and the 5-CSRTT under test conditions of both regular (5s) and short (2-5s) multiple ITI (Intertrial interval)...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27106138/apolipoprotein-e-apoe-genotype-and-the-pesticide-chlorpyrifos-modulate-attention-motivation-and-impulsivity-in-female-mice-in-the-5-choice-serial-reaction-time-task
#10
Fiona Peris-Sampedro, Ingrid Reverte, Pia Basaure, Maria Cabré, José L Domingo, Maria Teresa Colomina
Organophosphate pesticides - and chlorpyrifos (CPF) in particular - contribute to a wide range of neurobehavioural disorders. Most experimental research focuses on learning and memory processes, while other behaviours remain understudied. The isoforms of the human apolipoprotein E (apoE) confer different cognitive skills on their carriers, but data on this topic are still limited. The current study was performed to assess whether the APOE genotypic variability differently modulates the effects of CPF on attentional performance, inhibitory control and motivation...
June 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27079641/prefrontal-cortical-neuregulin-erbb-modulation-of-inhibitory-control-in-rats
#11
Maarten Loos, Dustin Schetters, Myrthe Hoogeland, Sabine Spijker, Taco J de Vries, Tommy Pattij
Impulse control disturbances are key features of various neuropsychiatric and neurological disorders, such as attention-deficit/hyperactivity disorder, drug addiction, Parkinson disease and schizophrenia. Whereas over the last years accumulating evidence has highlighted monoaminergic modulation of the processes underlying impulse control, investigating novel mechanisms beyond monoamines may provide new intervention strategies to ameliorate impulse control disturbances. Recent work has associated the neuregulin (Nrg)-ErbB pathway with several neuropsychiatric diseases, as well as indicated its involvement in murine measures of impulse control...
June 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26983414/a-mouse-model-of-the-15q13-3-microdeletion-syndrome-shows-prefrontal-neurophysiological-dysfunctions-and-attentional-impairment
#12
Simon R O Nilsson, Pau Celada, Kim Fejgin, Jonas Thelin, Jacob Nielsen, Noemí Santana, Christopher J Heath, Peter H Larsen, Vibeke Nielsen, Brianne A Kent, Lisa M Saksida, Tine B Stensbøl, Trevor W Robbins, Jesper F Bastlund, Timothy J Bussey, Francesc Artigas, Michael Didriksen
RATIONALE: A microdeletion at locus 15q13.3 is associated with high incidence rates of psychopathology, including schizophrenia. A mouse model of the 15q13.3 microdeletion syndrome has been generated (Df[h15q13]/+) with translational utility for modelling schizophrenia-like pathology. Among other deficits, schizophrenia is characterised by dysfunctions in prefrontal cortical (PFC) inhibitory circuitry and attention. OBJECTIVES: The objective of this study is to assess PFC-dependent functioning in the Df(h15q13)/+ mouse using electrophysiological, pharmacological, and behavioural assays...
June 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26875755/strain-dependency-of-the-effects-of-nicotine-and-mecamylamine-in-a-rat-model-of-attention
#13
Britta Hahn, Katelyn E Riegger, Greg I Elmer
RATIONALE: Processes of attention have a heritable component, suggesting that genetic predispositions may predict variability in the response to attention-enhancing drugs. Among lead compounds with attention-enhancing properties are nicotinic acetylcholine receptor (nAChR) agonists. OBJECTIVES: This study aims to test, by comparing three rat strains, whether genotype may influence the sensitivity to nicotine in the 5-choice serial reaction time task (5-CSRTT), a rodent model of attention...
April 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26540742/performance-of-transgenic-tgtau-p301l-mice-in-a-5-choice-serial-reaction-time-task-5-csrtt-as-a-model-of-alzheimer-s-disease
#14
Aamena Valiji Bharmal, Brianne A Kent, Timothy J Bussey, Lisa M Saksida
Alzheimer's disease is increasing to epidemic levels with an estimated 36 million people affected worldwide (Wimo 2010). The aetiology of the disease is not known, which is hindering the progression of the treatment. This study is a longitudinal investigation into the performance of TgTauP301L mice as an animal model of Alzheimer's disease on the computer automated touchscreen 5-choice serial reaction time task (5-CSRTT). TgTauP301L mice have a single tau mutation in the P301L gene and develop the tau pathology that represents the observed tauopathy in patients with Alzheimer's disease...
September 2015: Psychiatria Danubina
https://www.readbyqxmd.com/read/26528153/developmental-role-of-acetylcholinesterase-in-impulse-control-in-zebrafish
#15
Matthew O Parker, Alistair J Brock, Ari Sudwarts, Muy-Teck Teh, Fraser J Combe, Caroline H Brennan
Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioral component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in ache (ache (sb55/+)) showed lower levels of impulsivity in a 5-choice serial reaction time task (5-CSRTT) than wild type and ache(+∕+). Assessment of expression of cholinergic (nAChR), serotonergic (5-HT), and dopamine (DR) receptor mRNA in both adult and larval (9 dpf) ache (sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mRNA in ache (sb55/+) larvae, but no differences in adults...
2015: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/26522842/differences-in-the-performance-of-nk1r-knockout-and-wildtype-mice-in-the-5%C3%A2-choice-continuous-performance-test
#16
Ashley J Porter, Katharine Pillidge, S Clare Stanford, Jared W Young
Mice lacking functional NK1 (substance P-preferring) receptors typically display excessive inattentiveness (omission errors) and impulsivity (premature responses) when compared with wildtypes in the 5-Choice Serial Reaction-Time Test (5-CSRTT). These abnormal behaviours are analogous to those seen in humans suffering from Attention Deficit Hyperactivity Disorder (ADHD). Here we used the 5-Choice Continuous‑Performance Test (5C-CPT) to ascertain whether NK1R-/- mice also display excessive false alarms (an inappropriate response to a 'no-go' signal), which is another form of impulsive behaviour...
February 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26497539/attentional-performance-impulsivity-and-related-neurotransmitter-systems-in-apoe2-apoe3-and-apoe4-female-transgenic-mice
#17
Ingrid Reverte, Fiona Peris-Sampedro, Pia Basaure, Leticia Campa, Cristina Suñol, Margarita Moreno, José Luis Domingo, Maria Teresa Colomina
RATIONALE: The apolipoprotein E (apoE) genotype influences cognitive performance in humans depending on age and sex. While the detrimental role of the apoE4 isoform on spatial learning and memory has been well-established in humans and rodents, less is known on its impact on the executive functions. OBJECTIVES: We aimed to evaluate the effect of apoE isoforms (apoE2, apoE3, apoE4) on visuospatial attention and inhibitory control performance in female transgenic mice, and to determine the neurochemical and neuropharmacological basis of this potential relationship...
January 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26398952/hyperactivity-and-attention-deficits-in-mice-with-decreased-levels-of-stress-inducible-phosphoprotein-1-stip1
#18
Flavio H Beraldo, Anu Thomas, Benjamin Kolisnyk, Pedro H Hirata, Xavier De Jaeger, Amanda C Martyn, Jue Fan, Daniela F Goncalves, Matthew F Cowan, Talal Masood, Vilma R Martins, Robert Gros, Vania F Prado, Marco A M Prado
Stress-inducible phosphoprotein I (STIP1, STI1 or HOP) is a co-chaperone intermediating Hsp70/Hsp90 exchange of client proteins, but it can also be secreted to trigger prion protein-mediated neuronal signaling. Some mothers of children with autism spectrum disorders (ASD) present antibodies against certain brain proteins, including antibodies against STIP1. Maternal antibodies can cross the fetus blood-brain barrier during pregnancy, suggesting the possibility that they can interfere with STIP1 levels and, presumably, functions...
November 2015: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/26370145/from-impulses-to-maladaptive-actions-the-insula-is-a-neurobiological-gate-for-the-development-of-compulsive-behavior
#19
A Belin-Rauscent, M-L Daniel, M Puaud, B Jupp, S Sawiak, D Howett, C McKenzie, D Caprioli, M Besson, T W Robbins, B J Everitt, J W Dalley, D Belin
Impulsivity is an endophenotype of vulnerability for compulsive behaviors. However, the neural mechanisms whereby impulsivity facilitates the development of compulsive disorders, such as addiction or obsessive compulsive disorder, remain unknown. We first investigated, in rats, anatomical and functional correlates of impulsivity in the anterior insular (AI) cortex by measuring both the thickness of, and cellular plasticity markers in, the AI with magnetic resonance imaging and in situ hybridization of the immediate early gene zif268, respectively...
April 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26234588/contribution-of-n-methyl-d-aspartate-receptors-to-attention-and-episodic-spatial-memory-during-senescence
#20
Michael Guidi, Asha Rani, Semir Karic, Barrett Severance, Ashok Kumar, Thomas C Foster
A decrease in N-methyl-D-aspartate receptor (NMDAR) function is associated with age-related cognitive impairments. However, NMDAR antagonists are prescribed for cognitive decline associated with age-related neurodegenerative disease, raising questions as to the role of NMDAR activity in cognitive function during aging. The current studies examined effects of NMDAR blockade on cognitive task that are sensitive to aging. Young and middle-age rats were trained on the five-choice serial reaction time task (5-CSRTT) and challenged with MK-801 (0...
November 2015: Neurobiology of Learning and Memory
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