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https://www.readbyqxmd.com/read/29619407/theta-oscillations-organize-spiking-activity-in-higher-order-visual-thalamus-during-sustained-attention
#1
Chunxiu Yu, Yuhui Li, Iain M Stitt, Zhe Charles Zhou, Kristin K Sellers, Flavio Frohlich
Higher-order visual thalamus plays a fundamental but poorly understood role in attention-demanding tasks. To investigate how neuronal dynamics in higher-order visual thalamus are modulated by sustained attention, we performed multichannel electrophysiological recordings in the lateral posterior-pulvinar complex (LP/pulvinar) in the ferret ( Mustela putorius furo ). We recorded single unit activity and local field potential (LFP) during the performance of the five-choice serial reaction time task (5-CSRTT), which is used in both humans and animals as an assay of sustained attention...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29568692/longitudinal-evaluation-of-tau-p301l-transgenic-mice-reveals-no-cognitive-impairments-at-17-months-of-age
#2
Brianne A Kent, Christopher J Heath, Chi Hun Kim, Rosemary Ahrens, Paul E Fraser, Peter St George-Hyslop, Timothy J Bussey, Lisa M Saksida
Introduction: Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular accumulation of hyperphosphorylated tau in the form of neurofibrillary tangles, the presence of which is associated with cognitive deficits. Methods: We conducted a longitudinal behavioral study to provide a profile of the TgTau(P301L)23027 transgenic mouse in multiple cognitive domains across multiple ages...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29473089/the-effects-of-cariprazine-and-aripiprazole-on-pcp-induced-deficits-on-attention-assessed-in-the-5-choice-serial-reaction-time-task
#3
Samuel A Barnes, Jared W Young, Athina Markou, Nika Adham, István Gyertyán, Béla Kiss
RATIONALE: Attentional processing deficits are a core feature of schizophrenia, likely contributing to the persistent functional and occupational disability observed in patients with schizophrenia. The pathophysiology of schizophrenia is hypothesized to involve dysregulation of NMDA receptor-mediated glutamate transmission, contributing to disruptions in normal dopamine transmission. Preclinical investigations often use NMDA receptor antagonists, such as phencyclidine (PCP), to induce cognitive disruptions relevant to schizophrenia...
May 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29374304/differences-in-trait-impulsivity-do-not-bias-the-response-to-pharmacological-drug-challenge-in-the-rat-five-choice-serial-reaction-time-task
#4
Rebecca L Barlow, Jeffrey W Dalley, Anton Pekcec
RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the underlying neurobiology of this behavior are essential for the discovery of novel therapeutic agents. Various models may be used to assess impulsivity as measured by the five-choice serial reaction time task (5-CSRTT), including variable inter-trial interval (ITI) sessions, the selection of extreme high and low impulsivity phenotypes from a large outbred population of rats, as well as pharmacological challenges...
April 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29278697/downregulation-of-5-hydroxytryptamine-7-receptor-in-the-medial-prefrontal-cortex-ameliorates-impulsive-actions-in-animal-models-of-schizophrenia
#5
Wei Zhang, Junhui Liu, Jinteng Feng, Min Jia, Guangjian Zhang, Xiaopeng Wen
R mRNA in the mPFC was significantly decreased to 5-Hydroxytryptamine7 (5-HT7 ) receptors in the medial prefrontal cortex (mPFC) play a critical role in complex cognitive impairment in schizophrenia. The mouse model of schizophrenia was established through the neonatal administration of phencyclidine (nPCP). Recombinant adeno-associated virus-mediated gene knockdown was used to investigate the role of mPFC 5-HT7 receptor in the schizophrenia-like symptoms in mice. Under baseline conditions in the 5-choice serial reaction time task (5-CSRTT), nPCP produced a significant attentional impairment that was exacerbated when mice were tested under LITI...
April 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29230168/a-novel-dopamine-transporter-inhibitor-ce-123-improves-cognitive-flexibility-and-maintains-impulsivity-in-healthy-male-rats
#6
Agnieszka Nikiforuk, Predrag Kalaba, Marija Ilic, Volker Korz, Vladimir Dragačević, Judith Wackerlig, Thierry Langer, Harald Höger, Joanna Golebiowska, Piotr Popik, Gert Lubec
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter (DAT) are widely used for their potential to enhance cognitive abilities. However, commercially available drugs are of limited specificity for DAT, blocking also noradrenaline and serotonine transporters, that can lead to unwanted side effects in healthy subjects...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29155092/effects-of-medial-prefrontal-cortex-5-ht-7-receptor-knockdown-on-cognitive-control-after-acute-heroin-administration
#7
Huijun Zhong, Jie Dang, Zhenghao Huo, Zhanbing Ma, Jing Chen, Yong Huang, Yongsheng Zhu, Min Li
Heroin abuse is linked to a deleterious effect on cognitive functioning in the individual. Recent evidences suggest that the serotonin7 receptor (5-HT7 R) is engaged in the regulation of cognitive control and the drug use-associated behaviors. However, the role of 5-HT7 R in the cognitive control after acute heroin administration has not been studied. The present study aims to investigate whether the knockdown of the 5-HT7 R by virus-mediated gene silencing in the medial prefrontal cortex (mPFC) could ameliorate the acute heroin-induced cognitive impairments...
January 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29128305/methamphetamine-induced-impulsivity-during-chronic-methamphetamine-treatment-in-rats-effects-of-the-taar-1-agonist-ro5263397
#8
Zhaoxia Xue, Justin N Siemian, Bernard N Johnson, Yanan Zhang, Jun-Xu Li
Impulsivity is an important personality trait associated with several clinical syndromes including drug abuse. While repeated drug exposure is known to increase certain behavioral responses, such as locomotion, to subsequent drug exposure, few studies have examined whether such sensitization develops for impulsive behavior. In the current study we tested the effects of methamphetamine acutely, during the course of, and upon discontinuation of chronic methamphetamine treatment on impulsive behavior in two models, the 5-choice serial reaction time task (5-CSRTT) and the delay-discounting task which measure impulsive action and impulsive choice, respectively...
February 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29102783/influence-of-intertrial-interval-on-basal-and-drug-induced-impulsive-action-in-the-5-choice-serial-reaction-time-task-effects-of-d-amphetamine-and-%C3%A2-2-5-dimethoxy-4-iodoamphetamine-doi
#9
Ciaràn M Fitzpatrick, Vojislav S Maric, Simon T Bate, Jesper T Andreasen
Impulsivity is a characteristic of a number of neuropsychiatric disorders such as attention-deficit/hyperactivity disorder. The 5-choice serial reaction time task (5-CSRTT) is a rodent paradigm extensively used to assess attention and impulsivity. Notably, 5-CSRTT studies do not typically account for the reduction in premature responding, the measure of impulsive action, occurring upon repeated exposure to test sessions with long or variable intertrial intervals (ITIs). This present 5-CSRTT study investigated the use of variable ITIs (5, 10 or 15s) across 15 test days (4 training days followed by 1 drug test day per week for three weeks) as previous experience had shown that 4 training days would be sufficient to induce consistent premature response levels in male C57BL/6J mice...
November 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28964912/functional-coding-variation-in-the-presynaptic-dopamine-transporter-associated-with-neuropsychiatric-disorders-drives-enhanced-motivation-and-context-dependent-impulsivity-in-mice
#10
Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakely
Recent genetic analyses have provided evidence that clinical commonalities associated with different psychiatric diagnoses often have shared mechanistic underpinnings. The development of animal models expressing functional genetic variation attributed to multiple disorders offers a salient opportunity to capture molecular, circuit and behavioral alterations underlying this hypothesis. In keeping with studies suggesting dopaminergic contributions to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BPD) and autism spectrum disorder (ASD), subjects with these diagnoses have been found to express a rare, functional coding substitution in the dopamine (DA) transporter (DAT), Ala559Val...
January 30, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28892143/rodent-test-of-attention-and-impulsivity-the-5-choice-serial-reaction-time-task
#11
Guy A Higgins, Leo B Silenieks
The 5-choice serial reaction time task (5-CSRTT) is employed extensively to measure attention in rodents. The assay involves animals trained to respond to a brief, unpredictable visual stimulus presented in one of five locations. The effects of experimental manipulations on response speed and choice accuracy are measured, and each related to attentional performance. The 5-CSRTT is also used to measure motor impulsivity. Adapted from a human task, the 5-CSRTT can be employed with rodents or primates, highlighting its translational value...
September 11, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/28856391/dissociable-effects-of-cocaine-and-yohimbine-on-impulsive-action-and-relapse-to-cocaine-seeking
#12
Nienke Broos, Yvar van Mourik, Dustin Schetters, Taco J De Vries, Tommy Pattij
RATIONALE: A strong association has been demonstrated between various forms of impulsivity and addiction-like behavior in both humans and rats. OBJECTIVES: In this study, we investigated how impulsive action, as measured in the 5-choice serial reaction time task (5-CSRTT), is affected during various stages of cocaine taking and seeking and by relapse-provoking stimuli in animals that were trained both in an intravenous cocaine self-administration paradigm and in the 5-CSRTT...
November 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28741623/effects-of-suvorexant-a-dual-orexin-hypocretin-receptor-antagonist-on-impulsive-behavior-associated-with-cocaine
#13
Taylor A Gentile, Steven J Simmons, Mia N Watson, Krista L Connelly, Eugen Brailoiu, Yanan Zhang, John W Muschamp
Hypothalamic hypocretin (orexin) peptides mediate arousal, attention, and reward processing. Fibers containing orexins project to brain structures that govern motivated behavior, including the ventral tegmental area (VTA). A number of psychiatric conditions, including attention deficit hyperactivity disorder (ADHD) and substance use disorders, are characterized by deficits in impulse control, however the relationship between orexin and impulsive behavior is incompletely characterized. The effects of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsive-like behavior in rats were evaluated using the five-choice serial reaction time task (5-CSRTT) and delay discounting procedures...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28716096/optimizing-reproducibility-of-operant-testing-through-reinforcer-standardization-identification-of-key-nutritional-constituents-determining-reward-strength-in-touchscreens
#14
Eun Woo Kim, Benjamin U Phillips, Christopher J Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J Bussey, Chul Hoon Kim, Eosu Kim, Lisa M Saksida
Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal standard protocols, in addition to increased translational potential, reliability and accuracy. However, the impact of regional and national differences in the supplies of available reinforcers in this system on behavioural performance and inter-laboratory variability is an unknown and at present uncontrolled variable...
July 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28681089/a-novel-test-for-evaluating-horses-spontaneous-visual-attention-is-predictive-of-attention-in-operant-learning-tasks
#15
C Rochais, M Sébilleau, M Houdebine, P Bec, M Hausberger, S Henry
Attention is described as the ability to process selectively one aspect of the environment over others. In this study, we characterized horses' spontaneous attention by designing a novel visual attention test (VAT) that is easy to apply in the animal's home environment. The test was repeated over three consecutive days and repeated again 6 months later in order to assess inter-individual variations and intra-individual stability. Different patterns of attention have been revealed: 'overall' attention when the horse merely gazed at the stimulus and 'fixed' attention characterized by fixity and orientation of at least the visual and auditory organs towards the stimulus...
August 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28487067/selective-and-interactive-effects-of-d-2-receptor-antagonism-and-positive-allosteric-mglur4-modulation-on-waiting-impulsivity
#16
Sarah N Isherwood, Trevor W Robbins, Janet R Nicholson, Jeffrey W Dalley, Anton Pekcec
BACKGROUND: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D2 receptor antagonist eticlopride, on two distinct forms of impulsivity...
September 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28418405/adenosine-a-2a-receptor-and-erk-driven-impulsivity-potentiates-hippocampal-neuroblast-proliferation
#17
A Oliveros, C H Cho, A Cui, S Choi, D Lindberg, D Hinton, M-H Jang, D-S Choi
Dampened adenosine A2A receptor (A2A R) function has been implicated in addiction through enhancement of goal-directed behaviors. However, the contribution of the A2A R to the control of impulsive reward seeking remains unknown. Using mice that were exposed to differential reward of low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and the 5-choice serial reaction time task (5-CSRTT), we demonstrate that deficits of A2A R function promote impulsive responses. Antagonism of the A2A R lowered ERK1 and ERK2 phosphorylation in the dorsal hippocampus (dHip) and potentiated impulsivity during Pavlovian-conditioning and the 5-CSRTT...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28386698/comparison-of-some-behavioral-effects-of-d-and-l-methamphetamine-in-adult-male-rats
#18
Justin N Siemian, Zhaoxia Xue, Bruce E Blough, Jun-Xu Li
RATIONALE: Both l- and d-methamphetamine (l- and d-MA) are more potent to release norpepinephrine (NE) than dopamine, and the selectivity is greater for l-MA than d-MA. Little is known of the in vivo pharmacology of l-MA. OBJECTIVE: This study compared the effects of l-MA and d-MA in assays of nociception, behavioral disruption, and impulsivity. METHODS: Antinociceptive effects of d- and l-MA were examined in two pain assays: the warm water tail withdrawal test for acute nociception and the von Frey test in complete Freund's adjuvant (CFA)-treated rats for chronic inflammatory pain...
July 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28386221/deep-brain-stimulation-of-the-nucleus-accumbens-core-affects-trait-impulsivity-in-a-baseline-dependent-manner
#19
Maria C Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I Mesman, Damiaan Denys, Taco J De Vries, Tommy Pattij
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28378204/a-schizophrenia-relevant-5-choice-serial-reaction-time-task-for-mice-assessing-broad-monitoring-distractibility-and-impulsivity
#20
Huiping Huang, Simone Guadagna, Maddalena Mereu, Mariasole Ciampoli, Giacomo Pruzzo, Theresa Ballard, Francesco Papaleo
The 5-Choice Serial Reaction Time Task (5-CSRTT) is an automated test for rodents allowing the assessment of multiple cognitive measures. Originally designed to assess cognitive deficits relevant to attention deficit hyperactivity disorder, it has been widely used in the investigation of neural systems of attention. In the current study, we have set up a modified version, which reduced the training phase to only 8-9 days with minimal food deprivation and without single-housing. Furthermore, based on evidence that patients with schizophrenia are more impaired in broad monitoring abilities than in sustained attention, we successfully developed a protocol replicating the Spatial Attentional Resource Allocation Task (SARAT), used in humans to assess broad monitoring...
July 2017: Psychopharmacology
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