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Sublingual latex immunotherapy

Eleonora Nucera, Simona Mezzacappa, Alessandro Buonomo, Michele Centrone, Angela Rizzi, Paolo Francesco Manicone, Giampiero Patriarca, Arianna Aruanno, Domenico Schiavino
Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy...
April 2018: Postȩpy Dermatologii i Alergologii
Désirée Larenas-Linnemann, Jorge A Luna-Pech
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analyses...
June 2018: Current Opinion in Allergy and Clinical Immunology
Kannan Sridharan, Gowri Sivaramakrishnan
Latex allergy (LA) is a commonly observed entity for which sublingual immunotherapy (SLIT) has been shown to be effective in many small randomized clinical trials. The present study was conducted with an aim of systematically reviewing the existing literature on the efficacy and safety of SLIT in patients with LA and to apply the principles of meta-analysis. A search for randomized controlled trials with appropriate search strategy in PubMed and CENTRAL was conducted. Studies with documented clinical history of LA and SLIT administered in any dose, duration and regimen compared with placebo were included...
November 2017: Journal of Dermatological Treatment
Montserrat Fernández-Rivas
Fruit and vegetable allergies are the most prevalent food allergies in adolescents and adults. The identification of the allergens involved and the elucidation of their intrinsic properties and cross-reactivity patterns has helped in the understanding of the mechanisms of sensitisation and how the allergen profiles determine the different phenotypes. The most frequent yet contrasting fruit and vegetable allergies are pollen-food syndrome (PFS) and lipid transfer protein (LTP) syndrome. In PFS, fruit and vegetable allergies result from a primary sensitisation to labile pollen allergens, such as Bet v 1 or profilin, and the resulting phenotype is mainly mild, consisting of local oropharyngeal reactions...
2015: Chemical Immunology and Allergy
Adriano Bueno-De Sá, Angela Gaspar, Dirceu Solé, Mário Morais-Almeida
Latex allergy is still a public health problem responsible for some occupational diseases tough to be treated without removing the patient from his/her workspace. For patients allergic to latex, sublingual immunotherapy (SLIT) for latex is a tool that can be very useful. We report the case of a nurse with latex allergy who underwent successful desensitization to latex by SLIT, and discuss about possible causes of the success of this therapy.
October 2014: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Franco Frati, Erminia Ridolo, Nicola Fuiano, Salvatore Barberi, Ilaria Dell'Albani, Massimo Landi, Luisa Ricciardi, Guglielmo Scala, Cristoforo Incorvaia
INTRODUCTION: Sublingual immunotherapy (SLIT) was introduced as a safer option to subcutaneous immunotherapy (SCIT) which was associated with the possible occurrence of systemic reactions including anaphylaxis and, though very rarely, fatalities. Some anaphylactic reactions to SLIT are reported, mainly in adults but also in children. It is therefore important to investigate the risk factors related to such reactions. AREAS COVERED: Data from the literature on the safety of SLIT in children were reviewed...
July 2014: Expert Opinion on Drug Safety
Y Nagai, D Shiraishi, Y Tanaka, Y Nagasawa, S Ohwada, H Shimauchi, H Aso, Y Endo, S Sugawara
BACKGROUND: Sublingual immunotherapy (SLIT) has proven to be safe and efficient for the treatment of type I allergies. However, the mechanisms underlying allergen transportation within the sublingual compartment, the localization of antigens, and the identities of the cells responsible for this immunization remain incompletely understood. OBJECTIVE: In this study, we focused on the sublingual ductal system and analysed the localization and transportation of antigens after their sublingual application...
March 2015: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Enrico Compalati, Fulvio Braido, Giorgio Walter Canonica
The practice of administering sublingual immunotherapy for respiratory allergy is gaining more and more diffusion worldwide as a consequence of the robust demonstration of clinical efficacy and safety provided by recent high-powered and well-designed studies, confirming for individual seasonal allergens the results of previous metanalyses in adult and pediatric populations. Preliminary evidence derives from recent rigorous trials on perennial allergens, like house dust mites, and specifically designed studies addressed the benefits on asthma...
December 2013: Allergology International: Official Journal of the Japanese Society of Allergology
M Crivellaro, G Senna, G Marcer, G Passalacqua
Although avoidance of occupational triggers remains the primary step in the management of work-related allergies, immunological treatments (including biological agents and specific immunotherapy) can be regarded as potential therapeutic options for IgE-mediated diseases; for example, many studies with allergen-specific immunotherapy have been carried out on latex allergy, showing overall favorable results, at least with sublingual immunotherapy. On the other hand, only few case reports have suggested the efficacy of immunotherapy in baker's asthma as well as in laboratory animal-induced asthma...
July 2013: International Journal of Immunopathology and Pharmacology
Giovanni Passalacqua, Enrico Compalati, Giorgio Walter Canonica
Sublingual immunotherapy (SLIT) is a matter of only 20 years. Nonetheless, in this short period of time more than 60 randomized double blind placebo-controlled trials have been published, in addition to postmarketing surveillance studies and meta-analyses. The wide diffusion of SLIT in clinical practice and the large availability of experimental data prompted the WAO to publish a position paper on SLIT, to identify the indications, contraindications, and practical aspects of the treatment. On the basis of the available literature, SLIT is certainly indicated in allergic rhinitis in both adults and children...
July 2010: World Allergy Organization Journal
Eustachio Nettis, Pantalea Delle Donne, Elisabetta Di Leo, Paola Fantini, Giovanni Passalacqua, Roberto Bernardini, Giorgio Walter Canonica, Antonio Ferrannini, Angelo Vacca
OBJECTIVE: Latex allergy remains a significant problem, especially among certain professional categories, and specific immunotherapy has been suggested as a suitable therapeutic option. The objective of the this article is to review the available literature on clinical trials of specific immunotherapy in latex allergy. DATA SOURCES: Literature databases (PubMed, Embase, Google Scholar) were searched for latex immunotherapy clinical trials. STUDY SELECTIONS: Clinical trials (either open or randomized controlled) using subcutaneous or sublingual immunotherapy with latex extracts were selected...
September 2012: Annals of Allergy, Asthma & Immunology
Eva María Lasa Luaces, Ana Isabel Tabar Purroy, Blanca Esther García Figueroa, Marta Anda Apiñaniz, Maria Luisa Sanz Laruga, Monika Raulf-Heimsoth, Domingo Barber Hernández
BACKGROUND: As the frequency of natural rubber latex (NRL) allergy has increased, attempts have been made to diminish exposure in high-risk patients. Despite some good results, complete NRL avoidance was not possible, so latex immunotherapy was developed. OBJECTIVE: To examine variations in immunologic parameters, clinical efficacy, and safety of NRL sublingual immunotherapy (SLIT). METHODS: This prospective, observational, open, case-control study included 23 patients (18 patients receiving NRL SLIT and 5 controls)...
May 2012: Annals of Allergy, Asthma & Immunology
Gabriel Gastaminza, Jaime Algorta, Olga Uriel, Maria T Audicana, Eduardo Fernandez, Maria L Sanz, Daniel Muñoz
BACKGROUND: Natural rubber latex allergy is a common and unsolved health problem. Since the avoidance of exposure is very difficult, immunotherapy is strongly recommended, but before its use in patients, it is essential to prove the efficacy and safety of extracts.The aim of the present randomised, double-blind, placebo-controlled clinical trial was to assess the efficacy and tolerability of latex sublingual immunotherapy in adult patients undergoing permanent latex avoidance. METHODS: Twenty-eight adult latex-allergic patients (5 males and 23 females), with mean age of 39 years (range 24-57) were randomized to receive a commercial latex-sublingual immunotherapy or placebo during one year, followed by another year of open, active therapy...
2011: Trials
Giovanni Passalacqua, Enrico Compalati, Giorgio Walter Canonica
Sublingual immunotherapy (SLIT) represents a significant advance and it seems particularly suitable in pediatric patients. There are favorable results for food allergy in controlled trials. For latex allergy, the results of several trials are encouraging. For atopic dermatitis, previous experience with subcutaneous immunotherapy and some earlier trials suggest the possible application of SLIT in children with mild to moderate dermatitis and sensitization to dust mite, but this recommendation is considered insufficiently evidence based...
May 2011: Immunology and Allergy Clinics of North America
Valentina Pecora, Arianna Aruanno, Alessandro Buonuomo, Tiziana De Pasquale, Amira Colagiovanni, Vito Sabato, Angela Rizzi, Lucilla Pascolini, Anna Giulia Ricci, Giampiero Patriarca, Eleonora Nucera, Domenico Schiavino
No abstract text is available yet for this article.
July 2010: Contact Dermatitis
Eustachio Nettis, Elisabetta Di Leo, Gianfranco Calogiuri, Massimo Milani, Pantalea Delle Donne, Antonio Ferrannini, Angelo Vacca
OBJECTIVES: In latex allergic individuals the avoidance of all exposure to natural rubber latex products is recommended. Sublingual immunotherapy against latex has recently been proposed. The aim of the study is to evaluate the tolerability of sublingual immunotherapy with latex extract, by a double-blind, placebo-controlled study, according to a three-day build-up phase rush protocol in a population of patients with latex-induced contact urticaria without a professional exposure to latex...
August 2010: Current Medical Research and Opinion
Suna Buyukozturk, Ash Gelincik, Ferhan Ozşeker, Bahattin Colakoğlu, Murat Dal
BACKGROUND: Complete avoidance sometimes cannot be possible in latex-allergic health care workers. So far, very few double-blind placebo-controlled studies revealed the efficacy of sublingual latex immunotherapy (SLIT) in those patients. OBJECTIVE: Our aim was to evaluate the efficacy and safety of latex SLIT in health care workers. METHODS: 30 patients (all health care workers) diagnosed as latex allergic were advised to avoid latex exposure and were given information about the prevention measures and asked to return two months later...
April 2010: Annals of Allergy, Asthma & Immunology
L Terracciano, E Calcinai, S Avitabile, E Galli
Clinical efficacy of sublingual immunotherapy (SLIT) has been investigated during the last 20 years and results of several meta-analyses are available, showing clinical efficacy of SLIT in children both in allergic asthma and in rhinitis, but strict recommendations are not possible under current evidence. Minimum age for starting SLIT is not clearly defined but several position paper and guidelines indicate a lower limit of 5 years of age. Guidelines on allergic rhinitis suggests SLIT in patients not well controlled with drugs or those who refuse to use drugs...
October 2009: International Journal of Immunopathology and Pharmacology
Désirée Larenas-Linnemann
PURPOSE OF REVIEW: Sublingual (SLIT) and oral immunotherapy (OIT) are two variants of immunotherapy that might be especially of interest for children. After adult studies, lately many trials in children are published. However, the quality of published material varies. In the present review we analyze paediatric SLIT publications from the past 2 years in the light of a new system of evaluation of quality of evidence, the grading of recommendations assessment, development and evaluation system...
December 2009: Current Opinion in Allergy and Clinical Immunology
Cristoforo Incorvaia, Marina Mauro, Tiziana Cappelletti, Chiara Pravettoni, Gualtiero Leo, Gian G Riario-Sforza
Specific immunotherapy is the only treatment targeting the causes, and not only the symptoms, of allergic diseases. Sublingual immunotherapy (SLIT) was introduced and developed to solve the problem of the adverse reactions, uncommon but possibly severe and rarely fatal, to the traditional subcutaneous immunotherapy (SCIT). The evidence of SLIT efficacy concerns rhinitis and asthma caused by sensitization to pollens and to house dust mites, but there are increasing data suggesting that SLIT could be applied in forms of allergy hardly feasible for SCIT because of its poor safety (this is true for food allergy and latex allergy) or could be considered for new applications, such as atopic dermatitis or baker's asthma...
June 2009: Recent Patents on Inflammation & Allergy Drug Discovery
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