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Keywords Rheumatoid arthritis oxidative...

Rheumatoid arthritis oxidative stress

https://read.qxmd.com/read/38536526/pharmacological-and-immunomodulatory-modes-of-action-of-medically-important-phytochemicals-against-arthritis-a-molecular-insight
#1
REVIEW
Aqsa, Shaukat Ali, Muhammad Summer, Saima Yousaf, Laiba Nazakat, Shehzeen Noor
Arthritis is a common illness that affects joints and it may result in inflammation and pain. Even though arthritis usually affects older people, it can also affect children, adults, and both genders. Numerous arthritic mouse models have been developed but the CIA model of rheumatoid arthritis (RA) has received the most attention. With the use of steroids, DMARDs, and NSAIDs, therapy objectives such as reduced disease incidence and better pain management are achieved. Long-term usage of these therapeutic approaches may have negative side effects...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38531431/triterpenes-g-a-and-g-e-from-galphimia-glauca-with-anti-inflammatory-and-anti-arthritic-activity-in-mice
#2
JOURNAL ARTICLE
Santillan-Urquiza Mayra Alejandra, Pérez Salud, Vega-Avila Elisa, Jiménez-Ferrer Enrique, Rendón-Martínez Julissa, Tortoriello Jaime, Zamilpa Alejandro, Salinas-Sánchez David, Maribel Herrera-Ruiz
ETHNOPHARMACOLOGICAL RELEVANCE: Galphimia glauca is a medicinal plant that treats inflammatory and anti-rheumatic problems. Its anti-inflammatory capacity has been reported pharmacologically, attributed to the triterpenes G-A and G-E. AIM: The objective of the present work was to measure the anti-inflammatory and immunomodulatory effect of the methanolic extract (GgMeOH) of Galphimia glauca and the isolated galphimines G-A and G-E, first in an acute test of plantar edema with carrageenan, and later in the model of experimental-induced arthritis with CFA...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521432/a-systematic-review-on-polysaccharides-from-morinda-officinalis-how-advances-in-the-preparation-structural-characterization-and-pharmacological-activities
#3
REVIEW
Mengyun Liu, Chen Wang, Hongwei Zhang, Hui Guo, Le Kang, Hongwei Li, Kai Li
ETHNOPHARMACOLOGICAL RELEVANCE: Morinda officinalis How is called "Ba-Ji-Tian" in Traditional Chinese Medicine (TCM), which belongs to the genus Rubiaceae and is widely used for medicinal purposes in China and other eastern Asian countries. Morinda officinalis How polysaccharides (MOPs) are one of the key bioactive components, and have a variety of biological activities, such as antioxidation, antifatigue, enhanced immunity, antiosteoporosis, ect. AIM OF THE REVIEW: This review is aimed at providing comprehensive information of the latest preparation technologies, structural characterization, and pharmacological effects of MOPs...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38515982/advantages-of-chinese-herbal-medicine-in-treating-rheumatoid-arthritis-a-focus-on-its-anti-inflammatory-and-anti-oxidative-effects
#4
REVIEW
Xiaoyu Wang, Youqian Kong, Zeguang Li
Oxidative stress is a condition characterized by an imbalance between the oxidative and antioxidant processes within the human body. Rheumatoid arthritis (RA) is significantly influenced by the presence of oxidative stress, which acts as a pivotal factor in its pathogenesis. Elevated levels of mitochondrial reactive oxygen species (ROS) and inflammation have been found to be closely associated in the plasma of patients with RA. The clinical treatment strategies for this disease are mainly chemical drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), glucocorticoids (GCs) and biological agents, but it is difficult for patients to accept long-term drug treatment and its side effects...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38506417/anti-inflammatory-effect-of-echinacoside-in-collagen-induced-arthritis-via-nrf2-drp1-pathway
#5
JOURNAL ARTICLE
Xiaoyan Wang, Lingxinyu Li, Mengyun Zhang, Ruike Ji, Na Li, Kun Wang, Zhufeng Chen
BACKGROUND: Oxidative damage plays an important role in the progression of rheumatoid arthritis (RA). Emerging research evidence suggests that natural antioxidants may effectively ameliorate this disease. OBJECTIVES: To investigate the therapeutic effect of echinacoside (ECH) in a collagen-induced arthritis (CIA) mouse model and thus elucidate the underlying molecular mechanism in RA. MATERIAL AND METHODS: Collagen-induced arthritis mice were intraperitoneally administered 1% dimethyl sulfoxide (DMSO) (control) or 0...
March 20, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38479179/personalized-cardiovascular-risk-assessment-in-rheumatoid-arthritis-patients-using-circulating-molecular-profiles-and-their-modulation-by-tnfi-il6ri-and-jakinibs
#6
JOURNAL ARTICLE
Laura Muñoz-Barrera, Carlos Perez-Sanchez, Rafaela Ortega-Castro, Sagrario Corrales, Maria Luque-Tevar, Tomás Cerdó, Ismael Sanchez-Pareja, Pilar Font, Raquel Lopez-Mejías, Jerusalem Calvo, M Carmen Abalos-Aguilera, Desiree Ruiz-Vilchez, Pedro Segui, Christian Merlo, José Perez-Venegas, Ma Dolores Ruiz Montesino, Carlos Rodriguez-Escalera, Carmen Romero Barco, Antonio Fernandez-Nebro, Natalia Mena Vazque, Jose Luis Marenco, Julia Uceda Montañes, Javier Godoy-Navarrete, Alba Ma Cabezas-Lucena, Eduardo Collantes Estevez, Ma Angeles Aguirre, Miguel A González-Gay, Nuria Barbarroja, Alejandro Escudero-Contreras, Chary Lopez-Pedrera
BACKGROUND & OBJECTIVES: This study aimed to: 1) analyze the inflammatory profile of Rheumatoid Arthritis (RA) patients, identifying clinical phenotypes associated with cardiovascular (CV) risk; 2) evaluate biologic and targeted-synthetic disease-modifying antirheumatic drugs (b-DMARDs and ts-DMARDs': TNFi, IL6Ri, JAKinibs) effects; and 3) characterize molecular mechanisms in immune-cell activation and endothelial dysfunction. PATIENTS & METHODS: A total of 387 RA patients and 45 healthy donors were recruited, forming three cohorts: i) 208 RA patients with established disease but without previous CV events; ii) RA-CVD: 96 RA patients with CV events, and iii) 83 RA patients treated with b-DMARDs/ts-DMARDs for 6 months...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38473928/potential-rheumatoid-arthritis-associated-interstitial-lung-disease-treatment-and-computational-approach-for-future-drug-development
#7
REVIEW
Eunji Jeong, Hyunseok Hong, Yeon-Ah Lee, Kyoung-Soo Kim
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by swelling in at least one joint. Owing to an overactive immune response, extra-articular manifestations are observed in certain cases, with interstitial lung disease (ILD) being the most common. Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is characterized by chronic inflammation of the interstitial space, which causes fibrosis and the scarring of lung tissue. Controlling inflammation and pulmonary fibrosis in RA-ILD is important because they are associated with high morbidity and mortality...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38463248/an-overview-of-therapeutic-targeting-of-nrf2-signaling-pathway-in-rheumatoid-arthritis
#8
REVIEW
Sarmistha Saha
Rheumatoid arthritis (RA), an autoimmune condition that has a significant inflammatory component and is exacerbated by dysregulated redox-dependent signaling pathways. In RA, the corelationship between oxidative stress and inflammation appears to be regulated by the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. Furthermore, it has been shown that transcriptional pathways involving Nrf2 and NFκB significantly interact under conditions of oxidative stress and inflammation. Because pathologic cells in RA have a higher chance of surviving, Nrf2's influence on concomitant pathologic mechanisms in the disease is explained by its interaction with key redox-sensitive inflammatory pathways...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38443945/the-effects-of-intermittent-fasting-diet-on-quality-of-life-clinical-symptoms-inflammation-and-oxidative-stress-in-overweight-and-obese-postmenopausal-women-with-rheumatoid-arthritis-study-protocol-of-a-randomized-controlled-trial
#9
JOURNAL ARTICLE
Mahsa Ranjbar, Sakineh Shab-Bidar, Abdolrahman Rostamian, Hamed Mohammadi, Kurosh Djafarian
BACKGROUND: Rheumatoid arthritis (RA) is known as a chronic systemic autoimmune disorder that primarily targets synovial joints, and may cause pain and functional limitations. Studies show diet can have beneficial effects on symptoms and oxidative stress of this disease. Intermittent fasting (IF) is a dietary approach with cycles of fasting and intake. The current study aims to investigate the effect of IF on quality of life, clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with RA...
March 5, 2024: Trials
https://read.qxmd.com/read/38422325/schisandrin-b-ameliorates-adjuvant-induced-arthritis-in-rats-via-modulation-of-inflammatory-mediators-oxidative-stress-and-hif-1%C3%AE-vegf-pathway
#10
JOURNAL ARTICLE
Xueqiang Chen, Chunhong Liu, Jiaxin Deng, Taibao Xia, Xiaohai Zhang, Shuangtao Xue, Meng-Ke Song, Opeyemi Joshua Olatunji
OBJECTIVES: Schisandrin B (Sch B) has been shown to possess anti-inflammatory and antioxidant properties, however, its antirheumatoid arthritis properties and potential mechanism remain unexplored. This study evaluated the potential of Sch B in adjuvant-induced arthritic (AIA) rats. METHODS: AIA was induced by injecting 0.1 ml of CFA into the paw of rats and the animals were administered with Sch B (50 mg/kg) for 28 days. The effects of Sch B were evaluated using arthritis severity, serum levels of oxido-inflammatory, and metabolic index parameters...
February 29, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38377032/over-the-counter-anti-inflammatory-supplements-for-adjunctive-rheumatoid-arthritis-therapy-a-comprehensive-narrative-review
#11
REVIEW
Saliba Fares, Mourad Omar, Aoun Laurence, Saif Abu-Baker, Almardini Shaza, Haddadin Fadi, Mina Jonathan, Khattar Georges, Sangaraju Koushik, Bou Sanayeh Elie, Morcos Zeina, Habib Toni, Al Saidi Ibrahim, Slobodnick Anastasia
Rheumatoid arthritis (RA), a prevalent chronic disease, poses significant treatment challenges, including side effects and high costs of conventional therapies. This heightens interest in natural, over-the-counter (OTC) anti-inflammatory supplements as potential adjunctive treatments. Given their roles in mitigating inflammation and oxidative stress, key factors in RA pathogenesis, these supplements could offer valuable therapeutic adjunctive. Our review addresses this emerging area, providing insights into the efficacy and safety of these supplements in RA management...
February 3, 2024: Aging and Disease
https://read.qxmd.com/read/38368495/association-between-ischemia-modified-albumin-ima-and-peripheral-endothelial-dysfunction-in-rheumatoid-arthritis-patients
#12
JOURNAL ARTICLE
Gian Luca Erre, Ilaria Chessa, Stefania Bassu, Lorenzo Cavagna, Ciriaco Carru, Gianfranco Pintus, Roberta Giordo, Arduino Aleksander Mangoni, Giuseppe Damiano Sanna, Angelo Zinellu
The identification of circulating biomarkers of endothelial dysfunction (ED), a precursor to atherosclerosis, in rheumatoid arthritis (RA) would facilitate early risk stratification and prevention strategies. Ischemia-modified albumin (IMA) has emerged as a potential biomarker of oxidative stress, ischemia, and ED. However, studies examining the relationship between IMA and ED in RA patients are lacking. We measured serum IMA concentrations by using an albumin cobalt binding test and peripheral vasodilatory capacity by EndoPAT in 113 RA patients without previous cardiovascular events enrolled in the EDRA study (ClinicalTrials...
February 17, 2024: Scientific Reports
https://read.qxmd.com/read/38362131/effects-of-soy-bread-on-cardiovascular-risk-factor-inflammation-and-oxidative-stress-in-women-with-active-rheumatoid-arthritis-a-randomized-double-blind-controlled-trial
#13
JOURNAL ARTICLE
Afsaneh Sayyaf, Ehsan Ghaedi, Fatemeh Haidari, Elham Rajaei, Kambiz Ahmadi-Engali, Bijan Helli
UNLABELLED: Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder with widespread synovitis. Isoflavones, the main active component of soy, have been reported to have potent anti-inflammatory effects; the previous RA animal models showed the promising effect of soy supplementation. We aimed to evaluate the effect of soy bread on inflammatory markers and lipid profiles in RA patients. The present study was designed as a randomized controlled trial. RA patients were randomly allocated to obtain soy bread (n = 22) or placebo bread (n = 22) for 8 weeks...
January 2024: Clinical Nutrition Research
https://read.qxmd.com/read/38349407/fda-approved-disulfiram-as-a-novel-treatment-for-aggressive-leukemia
#14
JOURNAL ARTICLE
Mawar Karsa, Lin Xiao, Emma Ronca, Angelika Bongers, Dayna Spurling, Ayu Karsa, Sandra Cantilena, Anna Mariana, Tim W Failes, Greg M Arndt, Laurence C Cheung, Rishi S Kotecha, Rosemary Sutton, Richard B Lock, Owen Williams, Jasper de Boer, Michelle Haber, Murray D Norris, Michelle J Henderson, Klaartje Somers
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. Our previous evaluation of FDA-approved drugs for their antileukemic activity identified disulfiram, used for the treatment of alcoholism, as a candidate hit compound...
February 13, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38337595/malondialdehyde-serum-levels-in-a-full-characterized-series-of-430-rheumatoid-arthritis-patients
#15
JOURNAL ARTICLE
Nayra Merino de Paz, Juan Carlos Quevedo-Abeledo, Fuensanta Gómez-Bernal, Antonia de Vera-González, Pedro Abreu-González, Candelaria Martín-González, Miguel Ángel González-Gay, Iván Ferraz-Amaro
Background . Oxidative stress has been involved in the pathogenesis of rheumatoid arthritis (RA). The serum malondialdehyde (MDA) level is a reliable biomarker of oxidative stress status. In the present work, we aimed to analyze how a comprehensive characterization of the disease characteristics in RA, including a lipid profile, insulin resistance, and subclinical atherosclerosis, relates to serum MDA levels. Methods . In a cross-sectional study that included 430 RA patients, serum MDA levels were evaluated...
February 4, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38334255/anemoside-b4-alleviates-arthritis-pain-via-suppressing-ferroptosis-mediated-inflammation
#16
JOURNAL ARTICLE
Chenlu Guo, Yuanfen Yue, Bojun Wang, Shaohui Chen, Dai Li, Fangshou Zhen, Ling Liu, Haili Zhu, Min Xie
Chronic pain is the key manifestations of rheumatoid arthritis. Neuroinflammation in the spinal cord drives central sensitization and chronic pain. Ferroptosis has potentially important roles in the occurrence of neuroinflammation and chronic pain. In the current study, mouse model of collagen-induced arthritis was established by intradermal injection of type II collagen in complete Freund's adjuvant (CFA) solution. CFA inducement resulted in swollen paw and ankle, mechanical and spontaneous pain, and impaired motor coordination...
February 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38325715/pathophysiological-and-therapeutic-implications-of-neuropeptide-s-system-in-neurological-disorders
#17
REVIEW
Kamini R Shirsath, Vaishnavi K Patil, Sanjay N Awathale, Sameer N Goyal, Kartik T Nakhate
Neuropeptide S (NPS) is a 20 amino acids-containing neuroactive molecule discovered by the reverse pharmacology method. NPS is detected in specific brain regions like the brainstem, amygdala, and hypothalamus, while its receptor (NPSR) is ubiquitously expressed in the central nervous system (CNS). Besides CNS, NPS and NPSR are also expressed in the peripheral nervous system. NPSR is a G-protein coupled receptor that primarily uses Gq and Gs signaling pathways to mediate the actions of NPS. In animal models of Parkinsonism and Alzheimer's disease, NPS exerts a neuroprotective role...
February 5, 2024: Peptides
https://read.qxmd.com/read/38313833/antiarthritic-and-antioxidant-activities-of-antrocaryon-micraster-seed-extract-and-its-fractions
#18
JOURNAL ARTICLE
Emmanuel Kofi Kumatia, Prince Kyei Baffour, Peter Bolah
Rheumatoid arthritis (RA) is an incurable debilitating disease which attacks the joints and impairs quality of life. Antrocaryon micraster is used to treat RA in African traditional medicine. However, its antiarthritic activity has not been pharmacologically studied. This study, therefore, reports the antiarthritic and antioxidant activities of A. micraster seed extract and its fractions. The seed extract (ASE) was produced by Soxhlet extraction and partitioned into petroleum ether (ASEP), ethyl acetate (ASEE), and aqueous (ASEA) fractions...
2024: BioMed Research International
https://read.qxmd.com/read/38313166/evaluating-the-effect-of-ursodeoxycholic-acid-udca-in-comparison-with-dexamethasone-and-diclofenac-in-a-rat-model-of-rheumatoid-arthritis
#19
JOURNAL ARTICLE
Yamama Raad Abduljaleel, Ahmed Hamed Jwaid, Aseel Kamil Hussein
Ursodeoxycholic acid (UDCA) is known for its major effects on the liver, but its impact on autoimmune diseases is not well understood. This study aimed to assess the effectiveness of UDCA in controlling rheumatoid arthritis (RA) in an in vivo setting. Experimental RA was induced in rats using Freund's complete adjuvant, and the effects of UDCA (50,100 mg/kg) were compared to those of dexamethasone and diclofenac by measuring changes in paw size, IL-17, pro-inflammatory cytokines, oxidative stress (GSH, MDA), and radiological changes...
October 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38309846/mxene-nanosheet-derived-n-s-codoped-graphene-quantum-dots-for-ultrasensitive-and-selective-detection-of-3-nitro-l-tyrosine-in-human-serum
#20
JOURNAL ARTICLE
Nguyen Thi Ngoc Anh, Trung Viet Huynh, Van Thanh Nguyen, Thi Kim Anh Nguyen, Ruey-An Doong
3-Nitro-l-tyrosine (3NT) is an oxidative stress metabolite associated with neurodegenerative diseases such as Parkinson's disease and rheumatoid arthritis. In this study, the N, S-co-doped graphene quantum dots (NSGQDs) derived from nitrogen-doped Ti3 C2 Tx MXene nanosheet via the hydrothermal method in the presence of mercaptosuccinic acid was synthesized as an optical sensing probe to detect 3NT in human serum. Tetramethyl ammonium hydroxide, the nitrogen source and delamination agent, was used to prepare nitrogen-doped MXene nanosheets via one step at room temperature...
March 1, 2024: Analytica Chimica Acta
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