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https://www.readbyqxmd.com/read/28104967/a-survey-of-knowledge-attitude-and-practice-of-consumers-at-a-tertiary-care-hospital-regarding-the-disposal-of-unused-medicines
#1
Supriya Sonowal, Chetna Desai, Jigar D Kapadia, Mira K Desai
OBJECTIVES: To evaluate the knowledge, attitude and practice of consumers in India about disposal of unused medicines. MATERIALS AND METHODS: A questionnaire comprising 11 questions evaluating the Knowledge (2), Attitude (3) and Practice (6) of unused medicines was prepared and pre validated before administering to 200 consumers of medicines attending the outpatient department of Civil Hospital Ahmedabad, a tertiary care teaching hospital in Western India. Requisite permissions from Institutional Ethics Committee and informed consent were obtained prior to recruiting them for the study...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28103487/a-turn-on-thiol-functionalized-fluorescent-carbon-quantum-dot-based-chemosensory-system-for-arsenite-detection
#2
Pooja D, Sonia Saini, Anupma Thakur, Baban Kumar, Sachin Tyagi, Manoj K Nayak
Carbon quantum dots (CQDs) have emerged out as promising fluorescent probes for hazardous heavy metals detection in recent past. In this study, water soluble CQDs were synthesized by facile microwave pyrolysis of citric acid & cysteamine, and functionalized with ditheritheritol to impart thiol functionalities at surface for selective detection of toxic arsenite in water. Microscopic analysis reveals that the synthesized CQDs are of uniform size (diameter ∼5nm) and confirmed to have surface SH groups by FT-IR...
January 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103486/combined-toxic-effects-and-mechanisms-of-microsystin-lr-and-copper-on-vallisneria-natans-lour-hara-seedlings
#3
Zhi Wang, Junqian Zhang, Enhua Li, Liang Zhang, Xuelei Wang, Lirong Song
Microcystin-LR (MCLR) and copper are commonly found in eutrophic water bodies because of eutrophic run-offs, cyanobacterial blooms, and copper algicide applications. However, the ecotoxicological risk of their combination remains unknown. This study investigated the effect of MCLR, Cu, and their mixture on the growth and physiological responses of Vallisneria natans. Results showed that the combined toxicity of them was concentration dependent. Synergistic effects were elicited at low concentrations of MCLR and Cu exposure (≤0...
January 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28101730/concepts-for-studying-urban-environmental-justice
#4
REVIEW
Jason Corburn
PURPOSE OF REVIEW: This paper offers research frameworks for understanding and acting to address urban environmental justice. Urban neighborhoods tend to concentrate and colocate vulnerable people and toxic environments. Cities are also where the poor and people of color tend to be disproportionately exposed to environmental hazards, such as air pollution, lead in paint and water, and polluting industries. RECENT FINDINGS: Researchers and government agencies are increasingly recognizing the need to document cumulative exposures that the urban poor and people of color experience in addition to environmental hazards...
January 18, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28100255/early-life-exposure-to-air-pollution-and-greater-use-of-academic-support-services-in-childhood-a-population-based-cohort-study-of-urban-children
#5
Jeanette A Stingone, Katharine H McVeigh, Luz Claudio
BACKGROUND: There is a growing literature showing associations between prenatal and early-life exposure to air pollution and children's neurodevelopment. However, it is unclear if decrements in neurodevelopment observed in epidemiologic research translate into observable functional outcomes in the broader pediatric population. The objective of this study was to examine the association between early-life exposures to common urban air toxics and the use of academic support services, such as early intervention and special education within a population-based cohort of urban children...
January 18, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28098817/spatial-analysis-of-human-health-risk-due-to-arsenic-exposure-through-drinking-groundwater-in-taiwan-s-pingtung-plain
#6
Ching-Ping Liang, Yi-Chi Chien, Cheng-Shin Jang, Ching-Fang Chen, Jui-Sheng Chen
Chronic arsenic (As) exposure continues to be a public health problem of major concern worldwide, affecting hundreds of millions of people. A long-term groundwater quality survey has revealed that 20% of the groundwater in southern Taiwan's Pingtung Plain is clearly contaminated with a measured As concentration in excess of the maximum level of 10 µg/L recommended by the World Health Organization. The situation is further complicated by the fact that more than half of the inhabitants in this area continue to use groundwater for drinking...
January 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28096222/first-infant-formula-type-and-risk-of-islet-autoimmunity-in-the-environmental-determinants-of-diabetes-in-the-young-teddy-study
#7
Sandra Hummel, Andreas Beyerlein, Roy Tamura, Ulla Uusitalo, Carin Andrén Aronsson, Jimin Yang, Anne Riikonen, Åke Lernmark, Marian J Rewers, William A Hagopian, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Suvi M Virtanen, Jill M Norris
OBJECTIVE: Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow's milk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D...
January 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28093983/an-approach-towards-structure-based-antimicrobial-peptide-design-for-use-in-development-of-transgenic-plants-a-strategy-for-plant-disease-management
#8
Humaira Ilyas, Aritreyee Datta, Anirban Bhunia
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are ubiquitous and vital components of innate defense response that present themselves as potential candidates for drug design, aimed to control plant and animal diseases. Though their application for plant disease management has long been studied with natural AMPs, cytotoxicity and stability related shortcomings for the development of transgenic plants limits their usage. Newer technologies like molecular modelling, NMR spectroscopy and combinatorial chemistry allow screening for potent candidates and provide new avenues for the generation of rationally designed synthetic AMPs with multiple biological functions...
January 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28089966/revision-of-viable-environmental-monitoring-in-a-development-pilot-plant-based-on-quality-risk-assessment-a-case-study
#9
Ildikó No Ziegler, Judit No Borbély-Jakab, Lilla No Lilla Sugó, Réka J Kovács
In this case study, the principles of Quality Risk Management were applied to review sampling points and monitoring frequencies in the Hormonal Tableting unit of a Formulation Development Pilot Plant. In the cleanroom area premises of different functions are located, therefore a general method was established for the risk evaluation based on the Hazard Analysis and Critical Control Points (HACCP) method to evaluate these premises (i.e. production area itself and ancillary clean areas) from the point of view of microbial load and state in order to observe if the existing monitoring program met the emerged advanced monitoring practice...
January 15, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28080135/characteristics-properties-and-analytical-methods-of-amoxicillin-a-review-with-green-approach
#10
Bianca Aparecida de Marco, Jéssica Sayuri Hisano Natori, Stefany Fanelli, Eliane Gandolpho Tótoli, Hérida Regina Nunes Salgado
Bacterial infections are the second leading cause of global mortality. Considering this fact, it is extremely important studying the antimicrobial agents. Amoxicillin is an antimicrobial agent that belongs to the class of penicillins; it has bactericidal activity and is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this penicillin, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety...
January 12, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28079647/using-public-health-data-for-soil-pb-hazard-management-in-ohio
#11
John F Obrycki, Tyler Serafini, Darryl B Hood, Chris Alexander, Pam Blais, Nicholas T Basta
OBJECTIVES: To evaluate how frequently elevated soil lead (Pb) hazards (≥400 ppm Pb) were identified in existing blood Pb site investigations in Ohio. DESIGN: This study evaluated 3050 site investigations from the Ohio Department of Health for children with blood Pb levels at or above 10 μg dL that contained bare soil Pb data. SETTING: Data were collected from existing databases maintained by the Ohio Department of Health. PARTICIPANTS: All data were de-identified prior to analysis...
January 11, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28078982/phytochemicals-a-novel-and-prominent-source-of-anti-cancer-drugs-against-colorectal-cancer
#12
Ravikiran Mahadevappa, Hang Fai Kwok
Colorectal cancer (CRC) is a malignant disease whose incidence and mortality rates are greatly influenced by environmental factors. Under-treatment of CRC such as a poor diagnostic evaluation, less aggressive surgery, less intensive chemotherapy results in metastasizing of the primary tumor cells and recurrence of cancer. Prolonged chemotherapy treatment against cancer is hazardous to the patients, which also limits its use in cancer therapy. Current research in developing a novel anti-cancer agent, direct towards finding a better anti-metastatic and an anti-invasive drug with reduced side effects...
January 12, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28076380/a-device-independent-evaluation-of-carbonyl-emissions-from-heated-electronic-cigarette-solvents
#13
Ping Wang, Wenhao Chen, Jiawen Liao, Toshiki Matsuo, Kazuhide Ito, Jeff Fowles, Dennis Shusterman, Mark Mendell, Kazukiyo Kumagai
OBJECTIVES: To investigate how the two main electronic (e-) cigarette solvents-propylene glycol (PG) and glycerol (GL)-modulate the formation of toxic volatile carbonyl compounds under precisely controlled temperatures in the absence of nicotine and flavor additives. METHODS: PG, GL, PG:GL = 1:1 (wt/wt) mixture, and two commercial e-cigarette liquids were vaporized in a stainless steel, tubular reactor in flowing air ranging up to 318°C to simulate e-cigarette vaping...
2017: PloS One
https://www.readbyqxmd.com/read/28074782/the-need-for-a-life-cycle-based-aging-paradigm-for-nanomaterials-importance-of-real-world-test-systems-to-identify-realistic-particle-transformations
#14
Denise M Mitrano, Bernd Nowack
Assessing the risks of manufactured nanomaterials (MNM) has been almost exclusively focused on the pristine, as-produced materials with far fewer studies delving into more complex, real world scenarios. However, when considering a life-cycle perspective, it is clear that MNM released from commercial products during manufacturing, use and disposal are far more relevant both in terms of more realistic environmental fate and transport as well as environmental risk. The quantity in which the particles are released and their (altered) physical and chemical form should be identified and it is these metrics that should be used to assess the exposure and hazard the materials pose...
January 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28073454/molecular-tools-to-detect-anatoxin-a-genes-in-aquatic-ecosystems-toward-a-new-nested-pcr-based-method
#15
Benjamin Legrand, Jerome Lesobre, Jonathan Colombet, Delphine Latour, Marion Sabart
Over the last few decades, cyanobacterial mass occurrence has become a recurrent feature of aquatic ecosystems. This has led to ecosystem exposure and health hazards associated with cyanotoxin production. The neurotoxin anatoxin-a and its homologs can be synthesized by benthic cyanobacterial species in lotic systems, but also by planktonic lacustrine species such as Dolichospermum (also known as Anabaena). However, only a few studies have focused on anatoxin-a occurrence and its biosynthesis genes in freshwater lakes...
September 2016: Harmful Algae
https://www.readbyqxmd.com/read/28070262/experiences-of-women-regarding-gaps-in-preconception-care-services-in-the-iranian-reproductive-health-care-system-a-qualitative-study
#16
Roghieh Bayrami, Robab Latifnejad Roudsari, Hamid Allahverdipour, Mojgan Javadnoori, Habibollah Esmaily
INTRODUCTION: Despite the beginnings of preconception care (PCC) delivery around a decade ago in Iran, there are still significant gaps in its service delivery. The purpose of this study was to explore the perceptions and experiences of women as well as midwives toward gaps in PCC delivery in the Iranian reproductive health care system. METHODS: In this exploratory qualitative study, 27 married women and 13 midwives were recruited using purposive sampling from five health centers in Mashhad, Northeast of Iran...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28068073/spatially-explicit-mapping-of-heat-health-risk-utilizing-environmental-and-socioeconomic-data
#17
Kejia Hu, Xuchao Yang, Jieming Zhong, Fangrong Fei, Jiaguo Qi
Extreme heat events, a leading cause of weather-related fatality worldwide, are expected to intensify, last longer, and occur more frequently in the near future. In heat health risk assessments, a spatiotemporal mismatch usually exists between hazard (heat stress) data and exposure (population distribution) data. Such mismatch is present because demographic data are generally updated every couple of years and unavailable at the subcensus unit level, which hinders the ability to diagnose human risks. In the present work, a human settlement index based on multi-sensor remote sensing data, including nighttime light, vegetation index, and digital elevation model data, was used for heat exposure assessment on a per-pixel basis...
January 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28067541/listeria-monocytogenes-circulating-in-rabbit-meat-products-and-slaughterhouses-in-italy-prevalence-data-and-comparison-among-typing-results
#18
Alessandra De Cesare, Antonio Parisi, Renzo Mioni, Damiano Comin, Alex Lucchi, Gerardo Manfreda
Rabbit meat has outstanding dietetic and nutritional properties. However, few data on microbiological hazards associated with rabbit productions are available. In this study, the presence of Listeria monocytogenes was determined in 430 rabbit carcasses, 256 rabbit meat cuts and products, and 599 environmental sponges collected from four Italian rabbit slaughterhouses over a period of 1 year. Prevalence of L. monocytogenes among the 1285 rabbit meat and environmental samples was 11%, with statistically significant differences between slaughterhouses...
January 9, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28066132/resilience-and-the-population-history-of-the-kuril-islands-northwest-pacific-a-study-in-complex-human-ecodynamics
#19
Ben Fitzhugh, Erik Gjesfjeld, William Brown, Mark J Hudson, Jennie D Shaw
Living in remote places can strain the adaptive capacities of human settlers. It can also protect communities from external social, political and economic forces. In this paper, we present an archaeological population history of the Kuril Islands. This string of small volcanic islands on the margins of the Northwest Pacific was occupied by maritime hunting, fishing and gathering communities from the mid-Holocene to recent centuries. We bring together (1) 380 new and previously published archaeological radiocarbon dates, (2) a new paleodemographic model based on a radiocarbon-timestamped temporal frequency distribution of archaeological deposits, (3) recently published paleoclimate trends, and (4) recently published archaeological proxy evidence for changes in the extent of social networks...
October 17, 2016: Quaternary International: the Journal of the International Union for Quaternary Research
https://www.readbyqxmd.com/read/28064359/season-of-birth-and-the-risk-of-type-2-diabetes-in-adulthood-a-prospective-cohort-study-of-0-5-million-chinese-adults
#20
Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Xia Li, Ling Yang, Yiping Chen, Huarong Sun, Bo Yu, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
AIMS/HYPOTHESIS: Season of birth as a surrogate for potential environmental exposure during fetal development and early postnatal life has shown an inconsistent association with adult type 2 diabetes in white populations living in high-latitude regions. The present study aimed to examine the association between birth seasonality and risk of adult type 2 diabetes in Chinese individuals living across wide regions of low latitude and lower to middle latitude. METHODS: Participants from the China Kadoorie Biobank were enrolled during 2004-2008 and followed up until 31 December 2013...
January 7, 2017: Diabetologia
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