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Mitzi I Kuroda, Andres Hilfiker, John C Lucchesi
The sex chromosomes have special significance in the history of genetics. The chromosomal basis of inheritance was firmly established when Calvin Bridges demonstrated that exceptions to Mendel's laws of segregation were accompanied at the cytological level by exceptional sex chromosome segregation. The morphological differences between X and Y exploited in Bridges' experiments arose as a consequence of the evolution of the sex chromosomes. Originally a homologous chromosome pair, the degeneration of the Y chromosome has been accompanied by a requirement for increased expression of the single X chromosome in males...
October 2016: Genetics
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
No abstract text is available yet for this article.
October 6, 2016: Nature Medicine
Barry M Zee, Amy B Dibona, Artyom A Alekseyenko, Christopher A French, Mitzi I Kuroda
Defects in chromatin proteins frequently manifest in diseases. A striking case of a chromatin-centric disease is NUT-midline carcinoma (NMC), which is characterized by expression of NUT as a fusion partner most frequently with BRD4. ChIP-sequencing studies from NMC patients revealed that BRD4-NUT (B4N) covers large genomic regions and elevates transcription within these domains. To investigate how B4N modulates chromatin, we performed affinity purification of B4N when ectopically expressed in 293-TREx cells and quantified the associated histone posttranslational modifications (PTM) using proteomics...
2016: PloS One
Mitzy Pepper, David G Hamilton, Thomas Merkling, Nina Svedin, Bori Cser, Renee A Catullo, Sarah R Pryke, J Scott Keogh
The spectacular threat display of the savannah specialist Australo-Papuan frilled lizards has made them one of the world's most iconic reptiles. They are increasingly used as a model system for research in evolutionary biology and ecology but little is known of their population structure. Their distribution across northern Australia and southern New Guinea also provides an opportunity to examine biogeographic patterns as they relate to the large-scale movement of savannah habitat during the Plio/Pleistocene and the associated increase in aridity...
September 21, 2016: Molecular Phylogenetics and Evolution
Zewen Xiao, Weiwei Meng, David B Mitzi, Yanfa Yan
Synthesis of cubic-phase AgBi2I7 iodobismuthate thin films and fabrication of air-stable Pb-free solar cells using the AgBi2I7 absorber have recently been reported. On the basis of X-ray diffraction (XRD) analysis and nominal composition, it was suggested that the synthesized films have a cubic ThZr2H7 crystal structure with AgBi2I7 stoichiometry. Through careful examination of the proposed structure and computational evaluation of the phase stability and bandgap, we find that the reported "AgBi2I7" films cannot be forming with the ThZr2H7-type structure, but rather more likely adopt an Ag-deficient AgBiI4 type...
October 6, 2016: Journal of Physical Chemistry Letters
Kandy T Velazquez, Reilly T Enos, Meredith S Carson, Taryn L Cranford, Jackie Bader, Ioulia Chatzistamou, Udai Singh, Prakash S Nagarkatti, Mitzi Nagarkatti, J Mark Davis, James A Carson, E Angela Murphy
Obesity presents a significant public health concern given its association with increased cancer incidence, unfavorable prognosis, and metastasis. However, there is very little literature on the effects of weight-loss, following obesity, on risk for colon cancer or liver cancer. Therefore, we sought to study whether intentional weight loss through diet manipulation was capable of mitigating colon and liver cancer in mice. We fed mice with a high-fat diet (HFD) comprised of 47% carbohydrates, 40% fat, and 13% protein for 20 weeks to mimic human obesity...
September 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Annabelle South, Bec Hanley, Mitzy Gafos, Ben Cromarty, Richard Stephens, Kate Sturgeon, Karen Scott, William J Cragg, Conor D Tweed, Jacqueline Teera, Claire L Vale
No abstract text is available yet for this article.
2016: Trials
Julie E Finnell, Calliandra M Lombard, Michael N Melson, Narendra P Singh, Mitzi Nagarkatti, Prakash Nagarkatti, James R Fadel, Christopher S Wood, Susan K Wood
Social stress is a risk factor for psychiatric disorders, however only a subset of the population is susceptible while others remain resilient. Inflammation has been linked to the pathogenesis of psychosocial disorders in humans and may underlie these individual differences. Using a resident-intruder paradigm capable of revealing individual differences in coping behavior and inflammatory responses, the present study determined if resveratrol (RSV; 0, 10, 30mg/kg/day) protected against persistent stress-induced inflammation in socially defeated rats...
August 31, 2016: Brain, Behavior, and Immunity
Emily Youngblom, Mitzi Leah Murray, Peter H Byers
Genetic testing can be used to determine if unexplained fractures in children could have resulted from a predisposition to bone fractures, e.g., osteogenesis imperfecta. However, uncertainty is introduced if a variant of unknown significance (VUS) is identified. Proper interpretation of VUS in these situations is critical because of its influence on clinical care and in court rulings. This study sought to understand how VUS are interpreted and used by practitioners when there is a differential diagnosis including both osteogenesis imperfecta and non-accidental injury...
September 2016: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Georgia Woodfield, Mitzi Nisbet, Joe Jacob, Wing Mok, Michael R Loebinger, David M Hansell, Athol U Wells, Robert Wilson
BACKGROUND AND OBJECTIVE: Yellow nail syndrome (YNS) is a rare and poorly described disease process. In this case-control study, clinical features and findings on HRCT were compared with idiopathic bronchiectasis (IBx). METHODS: A review of all patients attending an adult bronchiectasis clinic between 2007 and 2013 identified 25 YNS patients. IBx patients were matched in a 2:1 ratio for age, duration of symptoms and gender. RESULTS: Median age of onset was 53 years...
August 23, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
René Aloisio da Costa Vieira, Guilherme Freire Angotti Carrara, Cristovam Scapulatempo Neto, Mariana Andozia Morini, Maria Mitzi Brentani, Maria Aparecida Azevedo Koike Folgueira
BACKGROUND: Breast conserving surgery (BCS) after neoadjuvant chemotherapy (NC) in patients with locally advanced breast cancer (LABC) is an infrequent procedure. In these patients the association with BCS and oncoplastic surgery (OS) is reported as a possible procedure in case-series, but there are limited case-control studies. METHODS: A matched case-control study evaluated LABC submitted to NC and BCS. We evaluated 78 patients submitted to doxorubicin-cyclophosphamide regimen followed by paclitaxel regimen...
September 2016: Annals of Medicine and Surgery
Marpe Bam, Xiaoming Yang, Elizabeth E Zumbrun, Yin Zhong, Juhua Zhou, Jay P Ginsberg, Quinne Leyden, Jiajia Zhang, Prakash S Nagarkatti, Mitzi Nagarkatti
Post-traumatic stress disorder patients experience chronic systemic inflammation. However, the molecular pathways involved and mechanisms regulating the expression of genes involved in inflammatory pathways in PTSD are reported inadequately. Through RNA sequencing and miRNA microarray, we identified 326 genes and 190 miRNAs that were significantly different in their expression levels in the PBMCs of PTSD patients. Expression pairing of the differentially expressed genes and miRNAs indicated an inverse relationship in their expression...
2016: Scientific Reports
Annabelle South, Bec Hanley, Mitzy Gafos, Ben Cromarty, Richard Stephens, Kate Sturgeon, Karen Scott, William J Cragg, Conor D Tweed, Jacqueline Teera, Claire L Vale
BACKGROUND: Patient and public involvement (PPI) in studies carried out by the UK Medical Research Council Clinical Trials Unit (MRC CTU) at University College London varies by research type and setting. We developed a series of case studies of PPI to document and share good practice. METHODS: We used purposive sampling to identify studies representing the scope of research at the MRC CTU and different approaches to PPI. We carried out semi-structured interviews with staff and patient representatives...
2016: Trials
Esmeralda Juárez, Claudia Carranza, Guadalupe Sánchez, Mitzi González, Jaime Chávez, Carmen Sarabia, Martha Torres, Eduardo Sada
New approaches for improving tuberculosis control using adjunct host-directed cellular and repurposed drug therapies are needed. Autophagy plays a crucial role in the response to tuberculosis, and a variety of autophagy-inducing drugs that are currently available for various medical conditions may serve as an adjunct treatment in pulmonary tuberculosis. Here, We evaluated the potential of loperamide, carbamazepine, valproic acid, verapamil and rapamycin to enhance the antimicrobial immune response to M. tuberculosis...
July 28, 2016: American Journal of Respiratory Cell and Molecular Biology
Mostafa M Ahmed, Matthew P Connor, Mitzi Palazzolo, Michelle E Thompson, Josh Lospinoso, Peter O'Connor, N Scott Howard, Stephen C Maturo
OBJECTIVES: Perform a follow-up study to investigate the histologic impact of high-dose intralaryngeal cidofovir injections in porcine vocal cords, either alone or in combination with bevacizumab, and compared to saline controls. STUDY DESIGN: This was an in vivo study involving 24 pigs with blinded pathologist review of specimens. Six groups were created, with four subjects in each group. Each subject received 10 or 20 mg of either cidofovir or bevacizumab alone, or in combination, injected into the right vocal cord...
July 25, 2016: Laryngoscope
Alexander A Chumanevich, Erin E Witalison, Anusha Chaparala, Anastasiya Chumanevich, Prakash Nagarkatti, Mitzi Nagarkatti, Lorne J Hofseth
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with an increased risk of colorectal cancer in 8-10 years after disease onset. Current colitis treatment strategies do not offer a cure for the disease, but only treat the symptoms with limited success and dangerous side-effects. Also, there is no preventive treatment for either UC or colorectal cancer. Quinacrine is an anti-malarial drug with versatile use in the treatment of diseases involving inflammatory response such as rheumatoid arthritis and lupus erythematosus...
July 14, 2016: Oncotarget
Michele Lowe, Rupert Handy, Joan Ingram, Mitzi Nisbet, Stephen Ritchie, Mark Thomas, Simon Briggs
BACKGROUND: Current guidelines recommend that women with HIV infection receive annual cervical smears. METHODS: We evaluated the uptake of annual cervical smears by women with HIV infection under the care of the Infectious Disease Service at Auckland City Hospital. In an attempt to identify potential barriers to regularly receiving an annual cervical smear, we invited the women to complete a questionnaire. The responses from women who had regularly received an annual cervical smear were compared with those who had not...
2016: New Zealand Medical Journal
Christopher G Hughes, Mayur B Patel, James C Jackson, Timothy D Girard, Sunil K Geevarghese, Brett C Norman, Jennifer L Thompson, Rameela Chandrasekhar, Nathan E Brummel, Addison K May, Mark R Elstad, Mitzi L Wasserstein, Richard B Goodman, Karel G Moons, Robert S Dittus, E Wesley Ely, Pratik P Pandharipande
OBJECTIVE: The aim of this study was to determine whether surgery and anesthesia exposure is an independent risk factor for cognitive impairment after major noncardiac surgery associated with critical illness. SUMMARY OF BACKGROUND DATA: Postoperative cognitive impairment is a prevalent individual and public health problem. Data are inconclusive as to whether this impairment is attributable to surgery and anesthesia exposure versus patients' baseline factors and hospital course...
July 18, 2016: Annals of Surgery
Manuel Salas, Lorena Rubio, Carmen Torrero, Mitzi Carreon, Mirelta Regalado
During the gestation and the lactating periods the gustatory papillae contain taste buds that respond to different flavors and aversive stimuli. The current study analyzed the effects of pre-and neonatal undernutrition on the circumvallate papillae of rats at 12, 20, and 30days of age. Early undernourishment occurred from gestational days G6 to G19 when dams received low percentages of food followed by a balanced diet from G20-21. After birth pups were underfed by rotating two lactating dams every 12h; in one of them, the nipples were tied...
July 2016: Acta Histochemica
Justin Reed, Mitzi Laughlin, Hawley Kunz, Mira Pistillo, Richard Simpson
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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