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https://www.readbyqxmd.com/read/28867182/deficiency-of-klf4-compromises-the-lung-function-in-an-acute-mouse-model-of-allergic-asthma
#1
Jeanette A Nimpong, Wintana Gebregziabher, Udai P Singh, Prakash Nagarkatti, Mitzi Nagarkatti, Johnie Hodge, Chunming Liu, Daping Fan, Walden Ai
Asthma is a chronic inflammatory disease of the airways and the mechanisms are not fully understood. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of monocytes, granulocyte and myeloid cells at early stage of differentiation. They possess phenotypic plasticity and regulate airway inflammation. We recently reported that Kruppel-like factor 4 (KLF4) regulates MDSC differentiation into fibrocytes, emerging effectors in chronic inflammation. However, the role of KLF4 in asthma is not known...
August 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28857632/adherence-persistence-and-discontinuation-among-hispanic-and-african-american-patients-with-multiple-sclerosis-treated-with-fingolimod-or-glatiramer-acetate
#2
Mitzi J Williams, Kristen Johnson, Helen M Trenz, Stephanie Korrer, Rachel Halpern, Yujin Park, Vivian Herrera
OBJECTIVE: Few studies have examined compliance to disease-modifying therapies (DMTs) for multiple sclerosis (MS) in minority populations. This study compared adherence, discontinuation, and persistence for fingolimod (FTY) and glatiramer acetate (GA) initiators among Hispanic and African American patients with MS. METHODS: This retrospective claims data study examined Hispanic and African American adults with MS who initiated FTY or GA between 1 September 2010 and 30 June 2014...
August 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28857382/nurse-manager-perspective-of-staff-participation-in-unit-level-shared-governance
#3
Sheila Cox Sullivan, Mitzi R Norris, Lana M Brown, Karen J Scott
AIM: To examine the nurse manager perspective surrounding implementation of unit level shared governance in one Veterans Health Administration facility. BACKGROUND: Nursing shared governance is a formal model allowing nursing staff decision-making input into clinical practice, quality improvement, evidence-based practice and staff professional development. Unit level shared governance is a management process where decision authority is delegated to nursing staff at the unit level...
August 30, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28851787/a-qualitative-study-exploring-the-social-and-environmental-context-of-recently-acquired-hiv-infection-among-men-who-have-sex-with-men-in-south-east-england
#4
Annabelle Gourlay, Julie Fox, Mitzy Gafos, Sarah Fidler, Nneka Nwokolo, Amanda Clarke, Richard Gilson, Chloe Orkin, Simon Collins, Kholoud Porter, Graham Hart
OBJECTIVES: A key UK public health priority is to reduce HIV incidence among gay and other men who have sex with men (MSM). This study aimed to explore the social and environmental context in which new HIV infections occurred among MSM in London and Brighton in 2015. DESIGN: A qualitative descriptive study, comprising in-depth interviews, was carried out as a substudy to the UK Register of HIV Seroconverters cohort: an observational cohort of individuals whose date of HIV seroconversion was well estimated...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821370/comparison-of-different-methods-of-semen-cryopreservation-in-melopsittacus-undulatus
#5
Andrea Dogliero, Mitzy Mauthe von Degerfeld, Ada Rota, Paola Pregel, Giuseppe Quaranta
Melopsittacus undulatus is largely used as a potential model for assisted reproduction in other endangered parrot species. Semen was collected from nineteen healthy adult males, by massage technique, during the breeding season. After preliminary evaluations through CASA analysis, eight birds were selected as semen donors and five ejaculates of each bird were utilized to evaluate the effect of 10% ethylene glycol (EG) addition, in two times, during 40min of equilibration time at 4°C, and to compare two programmable freezing curves (a rapid and a slow temperature descent rate) and freezing on nitrogen vapors...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28802311/aoac-smpr-%C3%A2-2015-016
#6
John Austad, Brad Barrett, Joseph M Betz, Carolyn Quarles Burdette, Clyde Don, Andy Erickson, James Griffiths, Jana B Hildreth, Prashant Ingle, Martha Jennens, David Ji, George Joseph, David C Kennedy, Elizabeth Mudge, Matthew Noestheden, Melissa Meaney Phillips, Curtis S Phinney, Mitzi Rettinger, Lanette D Richards, Catherine A Rimmer, Nandakumara Sarma, Berenice Sauza, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, John Szpylka, James Traub, Denise Lowe Walters, J P Woods, Jinchuan Yang, Seong-Jae Yoo, Troy Zhang, Weiguo Zhang, Yanjun Zhang, Joyce Zhu, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28759836/comparison-of-celioscopy-and-histological-examinations-to-assess-male-gonadal-health-and-functionality-in-adults-and-immature-wild-raptors
#7
Andrea Dogliero, Giacomo Rossi, Mitzy Mauthe von Degerfeld, Giuseppe Quaranta, Ada Rota
Celioscopy is routinely used in birds for sex determination and diagnostic purposes. Aim of this work was to validate celioscopy for the assessment of male gonads functionality in wild raptors, comparing the results of direct observation with morphometrical and histological characteristics. The work was done at the 'Centro Animali Non Convenzionali' of the University of Turin, Italy, on 31 endoscopically evaluated raptors that died or were euthanized. Through celioscopic observation, the birds were classified in adults or immatures and maturity categories were defined according to the adrenal-gonad size ratio and to the degree of blood filling of testicular vessels...
July 23, 2017: Theriogenology
https://www.readbyqxmd.com/read/28755410/chemical-origin-of-the-stability-difference-between-copper-i-and-silver-i-based-halide-double-perovskites
#8
Zewen Xiao, Ke-Zhao Du, Weiwei Meng, David B Mitzi, Yanfa Yan
Recently, Cu(I) - and Ag(I) -based halide double perovskites have been proposed as promising candidates for overcoming the toxicity and instability issues inherent within the emerging Pb-based halide perovskite absorbers. However, up to date, only Ag(I) -based halide double perovskites have been experimentally synthesized; there are no reports on successful synthesis of Cu(I) -based analogues. Here we show that, owing to the much higher energy level for the Cu 3d(10) orbitals than for the Ag 4d(10) orbitals, Cu(I) atoms energetically favor 4-fold coordination, forming [CuX4 ] tetrahedra (X=halogen), but not 6-fold coordination as required for [CuX6 ] octahedra...
July 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749282/oronasal-squamous-cell-carcinomas-in-fran%C3%A3-ois-langurs-trachypithecus-francoisi
#9
John A Flanders, Michelle E Thompson, Mitzi J Palazzolo, Michael M Garner, Matthew Reed, Donna M Ialeggio, Matti Kiupel, William H Westra, Kathryn C Gamble
Squamous cell carcinomas (SCCs) are common oronasal tumors in nonhuman primates. In this study, 11 cases of oronasal SCC in François' langurs ( Trachypithecus francoisi ) are described. Five initial cases were discovered on review of the North American François' langur studbook, with a potential familial pattern observed. The studbook was used to identify related individuals, and records were requested for review. Six additional cases were documented, and samples from all cases were submitted for microscopic review, as well as polymerase chain reaction (PCR), immunohistochemistry (IHC), and in situ hybridization (ISH), for generic papillomaviruses and PCR for herpesviruses because either virus may cause SCC in humans and other nonhuman primates...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749133/two-dimensional-lead-ii-halide-based-hybrid-perovskites-templated-by-acene-alkylamines-crystal-structures-optical-properties-and-piezoelectricity
#10
Ke-Zhao Du, Qing Tu, Xu Zhang, Qiwei Han, Jie Liu, Stefan Zauscher, David B Mitzi
A series of two-dimensional (2D) hybrid organic-inorganic perovskite (HOIP) crystals, based on acene alkylamine cations (i.e., phenylmethylammonium (PMA), 2-phenylethylammonium (PEA), 1-(2-naphthyl)methanammonium (NMA), and 2-(2-naphthyl)ethanammonium (NEA)) and lead(II) halide (i.e., PbX4(2-), X = Cl, Br, and I) frameworks, and their corresponding thin films were fabricated and examined for structure-property relationship. Several new or redetermined crystal structures are reported, including those for (NEA)2PbI4, (NEA)2PbBr4, (NMA)2PbBr4, (PMA)2PbBr4, and (PEA)2PbI4...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28737682/cadmium-handling-toxicity-and-molecular-targets-involved-during-pregnancy-lessons-from-experimental-models
#11
REVIEW
Tania Jacobo-Estrada, Mitzi Santoyo-Sánchez, Frank Thévenod, Olivier Barbier
Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the PubMed.gov website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28661658/correction-to-intrinsic-instability-of-cs2in-i-m-iii-x6-m-bi-sb-x-halogen-double-perovskites-a-combined-density-functional-theory-and-experimental-study
#12
Zewen Xiao, Ke-Zhao Du, Weiwei Meng, Jianbo Wang, David B Mitzi, Yanfa Yan
No abstract text is available yet for this article.
June 29, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28646020/mcam-mediates-chemoresistance-in-small-cell-lung-cancer-via-the-pi3k-akt-sox2-signaling-pathway
#13
Satyendra C Tripathi, Johannes F Fahrmann, Muge Celiktas, Mitzi Aguilar, Kieren D Marini, Mohit K Jolly, Hiroyuki Katayama, Hong Wang, Eunice N Murage, Jennifer B Dennison, D Neil Watkins, Herbert Levine, Edwin J Ostrin, Ayumu Taguchi, Samir M Hanash
Despite favorable responses to initial therapy, small-cell lung cancer (SCLC) relapse occurs within a year and exhibits resistance to multiple drugs. Because of limited accessibility of patient tissues for research purposes, SCLC patient-derived xenografts (PDX) have provided the best opportunity to address this limitation. Here, we sought to identify novel mechanisms involved in SCLC chemoresistance. Through in-depth proteomic profiling, we identified MCAM as a markedly upregulated surface receptor in chemoresistant SCLC cell lines and in chemoresistant PDX compared with matched treatment-naïve tumors...
August 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28629965/%C3%A2-cortical-atrophy-is-associated-with-accelerated-cognitive-decline-in-mild-cognitive-impairment-with-subsyndromal-depression
#14
Mitzi M Gonzales, Philip S Insel, Craig Nelson, Duygu Tosun, Niklas Mattsson, Susanne G Mueller, Simona Sacuiu, David Bickford, Michael W Weiner, R Scott Mackin
OBJECTIVES: To investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and chronic subsyndromal symptoms of depression (SSD) over a 4-year period. DESIGN: Prospective cohort study. SETTING: Multicenter, clinic-based. PARTICIPANTS: Within the Alzheimer's Disease Neuroimaging Initiative repository, the Neuropsychiatric Inventory was used to identify individuals with MCI and stable endorsement (SSD group N = 32) or no endorsement (non-SSD group N = 69) of depressive symptoms across time points...
April 20, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28604528/clinical-nurse-specialist-perceptions-of-spiritual-care-nurses-need-support-care-falls-short
#15
Mitzi M Saunders, Karen Harris, Deborah L Hale
The clinical nurse specialist (CNS) is positioned to influence spiritual care at three levels of practice: patient, nurse, and system. This study, the first to explore CNS spiritual care, reports on CNSs' perceptions in providing spiritual care. Four themes were extracted from interview data: 1) Providing direct spiritual support for patients, 2) Nurses need support in providing spiritual care, 3) Using existing resources, and 4) Spiritual care falls short. Not one CNS mentioned barriers to their direct provision of spiritual care...
July 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/28604009/parity-forbidden-transitions-and-their-impact-on-the-optical-absorption-properties-of-lead-free-metal-halide-perovskites-and-double-perovskites
#16
Weiwei Meng, Xiaoming Wang, Zewen Xiao, Jianbo Wang, David B Mitzi, Yanfa Yan
Using density functional theory calculations, we analyze the optical absorption properties of lead (Pb)-free metal halide perovskites (AB(2+)X3) and double perovskites (A2B(+)B(3+)X6) (A = Cs or monovalent organic ion, B(2+) = non-Pb divalent metal, B(+) = monovalent metal, B(3+) = trivalent metal, X = halogen). We show that if B(2+) is not Sn or Ge, Pb-free metal halide perovskites exhibit poor optical absorptions because of their indirect band gap nature. Among the nine possible types of Pb-free metal halide double perovskites, six have direct band gaps...
June 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28578388/antibody-blockade-of-clec12a-delays-eae-onset-and-attenuates-disease-severity-by-impairing-myeloid-cell-cns-infiltration-and-restoring-positive-immunity
#17
Divya Sagar, Narendra P Singh, Rashida Ginwala, Xiaofang Huang, Ramila Philip, Mitzi Nagarkatti, Prakash Nagarkatti, Konstantin Neumann, Jürgen Ruland, Allison M Andrews, Servio H Ramirez, Zafar K Khan, Pooja Jain
The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we identified functions of one C-type lectin receptor, CLEC12A, in facilitating DC binding and transmigration across the BBB in response to CCL2 chemotaxis. To test function of CLEC12A in an animal model of multiple sclerosis (MS), we administered blocking antibody to CLEC12A that significantly ameliorated disease scores in MOG35-55-induced progressive, as well as PLP138-151-induced relapsing-remitting experimental autoimmune encephalomyelitis (EAE) mice...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28565917/differences-in-carbon-source-utilization-of-salmonella-oranienburg-and-saintpaul-isolated-from-river-water
#18
Andrés Medrano-Félix, Mitzi Estrada-Acosta, Felipe Peraza-Garay, Nohelia Castro-Del Campo, Jaime Martínez-Urtaza, Cristóbal Chaidez
Long-term exposure to river water by non-indigenous micro-organisms such as Salmonella may affect metabolic adaptation to carbon sources. This study was conducted to determine differences in carbon source utilization of Salmonella Oranienburg and Salmonella Saintpaul (isolated from tropical river water) as well as the control strain Salmonella Typhimurium exposed to laboratory, river water, and host cells (Hep-2 cell line) growth conditions. Results showed that Salmonella Oranienburg and Salmonella Saintpaul showed better ability for carbon source utilization under the three growth conditions evaluated; however, S...
May 31, 2017: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/28543188/cd44-deletion-leading-to-attenuation-of-experimental-autoimmune-encephalomyelitis-results-from-alterations-in-gut-microbiome-in-mice
#19
Kumaraswamy Naidu Chitrala, Hongbing Guan, Narendra P Singh, Brandon Busbee, Alexa Gandy, Pegah Mehrpouya-Bahrami, Mitra S Ganewatta, Chuanbing Tang, Saurabh Chatterjee, Prakash Nagarkatti, Mitzi Nagarkatti
Dysbiosis in gut microbiome has been shown to be associated with inflammatory and autoimmune diseases. Previous studies from our laboratory demonstrated the pivotal role played by CD44 in the regulation of EAE, a murine model of multiple sclerosis. In the current study, we determined whether these effects resulted from an alteration in gut microbiota and the short-chain fatty acid (SCFA) production in CD44 knockout (CD44KO) mice. Fecal transfer from naïve CD44KO but not C57BL/6 wild type (CD44WT) mice, into EAE-induced CD44WT mice, led to significant amelioration of EAE...
May 23, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28523742/bandgap-engineering-of-lead-free-double-perovskite-cs2-agbibr6-through-trivalent-metal-alloying
#20
Ke-Zhao Du, Weiwei Meng, Xiaoming Wang, Yanfa Yan, David B Mitzi
The double perovskite family, A2 M(I) M(III) X6 , is a promising route to overcome the lead toxicity issue confronting the current photovoltaic (PV) standout, CH3 NH3 PbI3 . Given the generally large indirect band gap within most known double perovskites, band-gap engineering provides an important approach for targeting outstanding PV performance within this family. Using Cs2 AgBiBr6 as host, band-gap engineering through alloying of In(III) /Sb(III) has been demonstrated in the current work. Cs2 Ag(Bi1-x Mx )Br6 (M=In, Sb) accommodates up to 75 % In(III) with increased band gap, and up to 37...
May 18, 2017: Angewandte Chemie
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