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https://www.readbyqxmd.com/read/29759729/recyclable-magnetic-nanoparticles-grafted-with-antimicrobial-metallopolymer-antibiotic-bioconjugates
#1
Parasmani Pageni, Peng Yang, Marpe Bam, Tianyu Zhu, Yung Pin Chen, Alan W Decho, Mitzi Nagarkatti, Chuanbing Tang
Over-prescription and improper use of antibiotics has led to the emergence of bacterial resistance, posing a major threat to public health. There has been significant interest in the development of alternative therapies and agents to combat antibiotic resistance. We report the preparation of recyclable magnetic iron oxide nanoparticles grafted with charged cobaltocenium-containing metallopolymers by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. β-Lactam antibiotics were then conjugated with metallopolymers to enhance their vitality against both Gram-positive and Gram-negative bacteria...
May 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29751049/increased-butyrate-priming-in-the-gut-stalls-microbiome-associated-gastrointestinal-inflammation-and-hepatic-metabolic-reprogramming-in-a-mouse-model-of-gulf-war-illness
#2
Ratanesh Kumar Seth, Diana Kimono, Firas Alhasson, Sutapa Sarkar, Muayad Albadrani, Stephen K Lasley, Ronnie Horner, Patricia Janulecewicz, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Saurabh Chatterjee
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical and pharmaceutical exposures during the war. Since an increased number of veterans complain of gastrointestinal (GI), neuroinflammatory and metabolic complications as they age and there are limited options for a cure, the present study was focused to assess the role of butyrate, a short chain fatty acid for attenuating GWI-associated GI and metabolic complications. Results in a GWI-mouse model of permethrin and pyridostigmine bromide (PB) exposure showed that oral butyrate restored gut homeostasis and increased GPR109A receptor copies in the small intestine (SI)...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29707158/differential-role-of-cxcr3-in-inflammation-and-colorectal-cancer
#3
REVIEW
Jessicca D Abron, Narendra P Singh, Angela E Murphy, Manoj K Mishra, Robert L Price, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh
Chemokines (CXCR3) and their ligands (CXCL9, CXCL10, and CXCL11) exert exquisite control over T-cell trafficking and are critical for activation, differentiation and effector T cell function. CXCR3 is important for CD4 Th1 cells, CD8 effectors, memory cells, and for the function of natural killer and natural killer T cells. The presence of high cytotoxic CXCR3 ligand expression on CD8 T cells in colorectal cancerous tissue has been well documented in the past. CXCR3 and its ligands are differentially expressed at sites of inflammation and within the tumors...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701516/clinical-findings-and-outcomes-for-dogs-with-uveodermatologic-syndrome
#4
Mitzi K Zarfoss, Charlotte A Tusler, Philip H Kass, Keith Montgomery, Christine C Lim, Freya Mowat, Sara M Thomasy
OBJECTIVE To evaluate signalment, clinical signs, treatment, and factors affecting visual prognosis in dogs with uveodermatologic syndrome (UDS). DESIGN Retrospective case series and nested cohort study. ANIMALS 50 dogs (37 Akitas and 13 non-Akitas) with UDS evaluated at 4 ophthalmology practices. PROCEDURES Data were collected from the medical records regarding signalment, clinical signs, biopsy results, medications, adverse effects, vision and glaucoma status at initial and subsequent examinations, and duration of follow-up...
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29699700/the-effects-of-cognitive-behavior-therapy-for-depression-on-repetitive-negative-thinking-a-meta-analysis
#5
Philip Spinhoven, Nicola Klein, Mitzy Kennis, Angélique O J Cramer, Greg Siegle, Pim Cuijpers, Johan Ormel, Steve D Hollon, Claudi L Bockting
It is not clear if treatments for depression targeting repetitive negative thinking (RNT: rumination, worry and content-independent perseverative thinking) have a specific effect on RNT resulting in better outcomes than treatments that do not specifically target rumination. We conducted a systematic search of PsycINFO, PubMed, Embase and the Cochrane library for randomized trials in adolescents, adults and older adults comparing CBT treatments for (previous) depression with control groups or with other treatments and reporting outcomes on RNT...
April 17, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29686677/mir-466a-targeting-of-tgf-%C3%AE-2-contributes-to-foxp3-regulatory-t-cell-differentiation-in-a-murine-model-of-allogeneic-transplantation
#6
William Becker, Mitzi Nagarkatti, Prakash S Nagarkatti
The promise of inducing immunological tolerance through regulatory T cell (Treg) control of effector T cell function is crucial for developing future therapeutic strategies to treat allograft rejection as well as inflammatory autoimmune diseases. In the current study, we used murine allograft rejection as a model to identify microRNA (miRNA) regulation of Treg differentiation from naïve CD4 cells. We performed miRNA expression array in CD4+ T cells in the draining lymph node (dLN) of mice which received syngeneic or allogeneic grafts to determine the molecular mechanisms that hinder the expansion of Tregs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29672155/an-endogenous-aryl-hydrocarbon-receptor-ahr-ligand-ite-induces-regulatory-t-cells-tregs-and-ameliorates-experimental-colitis
#7
Jessicca D Abron, Narendra P Singh, Manoj K Mishra, Robert L Price, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that affects millions of people with high morbidity and health-care cost. The precise etiology of IBD is unknown, but clear evidence suggests that intestinal inflammation is caused by an excessive immune response to mucosal antigens. Recent studies have shown that activation of the aryl hydrocarbon receptor (AhR) induces regulatory T cells (Tregs) and suppresses autoimmune diseases. In the current study, we investigated if nontoxic ligand of AhR, 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), can attenuate dextran sodium sulphate (DSS)-induced colitis...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29660503/high-circulatory-leptin-mediated-nox-2-peroxynitrite-mir21-axis-activate-mesangial-cells-and-promotes-renal-inflammatory-pathology-in-nonalcoholic-fatty-liver-disease
#8
Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A Kimono, Muayad S Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin in NAFLD is associated with renal disease severity. Extending the studies, we hypothesized that high circulatory leptin in NAFLD causes renal mesangial cell activation and tubular inflammation via a NOX2 dependent pathway that upregulates proinflammatory miR21...
April 7, 2018: Redox Biology
https://www.readbyqxmd.com/read/29656052/autologous-serum-collected-1h-post-exercise-enhances-natural-killer-cell-cytotoxicity
#9
Priti Gupta, Austin B Bigley, Melissa Markofski, Mitzi Laughlin, Emily C LaVoy
Natural Killer cells are cytotoxic lymphocytes that recognize and eliminate tumor cells. Exercise enhances NK cell cytotoxic activity (NKCA), yet the underlying mechanisms are not fully understood. Exercise-induced shifts in NK-cell subsets has been proposed as one mechanism. Alternatively, exercise alters stress hormone and cytokine levels, which are also known to affect NKCA. AIM: Determine the role(s) of exercise-induced shifts in the proportions of NK-cell subsets found in the blood, and changes in serum IL-2, IL-6, IL-12, IFN-γ, TNF-α and cortisol, on exercise-induced changes in NKCA...
April 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29512867/resveratrol-protects-mice-against-seb-induced-acute-lung-injury-and-mortality-by-mir-193a-modulation-that-targets-tgf-%C3%AE-signalling
#10
Hasan Alghetaa, Amira Mohammed, Muthanna Sultan, Philip Busbee, Angela Murphy, Saurabh Chatterjee, Mitzi Nagarkatti, Prakash Nagarkatti
Staphylococcal enterotoxin B (SEB) is a potent superantigen produced by Staphylococcus aureus that triggers a strong immune response, characterized by cytokine storm, multi-organ failure, and often death. When inhaled, SEB can cause acute lung injury (ALI) and respiratory failure. In this study, we investigated the effect of resveratrol (RES), a phytoallexin, on SEB-driven ALI and mortality in mice. We used a dual-exposure model of SEB in C3H/HeJ mice, which caused 100% mortality within the first 5 days of exposure, and treatment with RES resulted in 100% survival of these mice up to 10 days post-SEB exposure...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29479354/withaferin-a-associated-differential-regulation-of-inflammatory-cytokines
#11
Seema Dubey, Hyunho Yoon, Mark Steven Cohen, Prakash Nagarkatti, Mitzi Nagarkatti, Dev Karan
A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary agent withaferin A (WFA). Membrane-based cytokine array profiling of the culture supernatant from adenosine triphosphate-stimulated WFA-treated THP-1 cells showed differential regulation of multiple cytokines/chemokines. A selected group of cytokines/chemokines [interleukin-1 beta (IL-1β), CCL2/MCP-1, granulocyte-macrophage colony stimulating factor, PDGF-AA, PTX3, cystatin-3, relaxin-2, TNFRSF8/CD30, and ACRP30] was validated at the transcription level using qPCR...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29460338/mdscs-drive-the-process-of-endometriosis-by-enhancing-angiogenesis-and-are-a-new-potential-therapeutic-target
#12
Tao Zhang, Juhua Zhou, Gene Chi Wai Man, Kam Tong Leung, Bo Liang, Bo Xiao, Xinting Ma, Shaoyan Huang, Huaxiang Huang, Venkatesh L Hegde, Yin Zhong, Yanmin Li, Grace Wing Shan Kong, Alice Ka Wah Yiu, Joseph Kwong, Pak Cheung Ng, Bruce A Lessey, Prakash S Nagarkatti, Mitzi Nagarkatti, Chi Chiu Wang
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with endometriosis and in the peritoneal cavity of a mouse model of surgically induced endometriosis. Majority of MDSCs were granulocytic, produced ROS, and arginase, and suppressed T-cell proliferation...
February 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29442214/en-masse-lentiviral-gene-delivery-to-mouse-fertilized-eggs-via-laser-perforation-of-zona-pellucida
#13
Negin P Martin, Page Myers, Eugenia Goulding, Shih-Heng Chen, Mitzie Walker, Thomas M Porter, Lucas Van Gorder, Amanda Mathew, Artiom Gruzdev, Charles Romeo
Lentiviruses are highly efficient vehicles for delivering genes into cells. They readily transduce primary and immortalized cells in vivo and in vitro. Genes delivered by lentiviruses are incorporated and replicated as part of their host genome and therefore offer a powerful tool for creation of stable cell lines and transgenic animals. However, the zona pellucida surrounding the fertilized eggs acts as a barrier and hinders lentiviral transduction of embryos. Here, we utilize a laser, typically used to perforate the zona pellucida for in vitro fertilization, to permeabilize the zona for lentiviral gene delivery...
February 2018: Transgenic Research
https://www.readbyqxmd.com/read/29420808/jc-polyoma-viruria-associates-with-protection-from-chronic-kidney-disease-independently-from-apolipoprotein-l1-genotype-in-african-americans
#14
Barry I Freedman, Amy L Kistler, Peter Skewes-Cox, Don Ganem, Mitzie Spainhour, Jolyn Turner, Jasmin Divers, Carl D Langefeld, Mariana Murea, Pamela J Hicks, Ashok K Hemal, James A Snipes, Lihong Zhao, Johanna R Abend, Douglas S Lyles, Lijun Ma, Karl L Skorecki
Background: Viral infections can trigger chronic kidney disease (CKD) and the urine virome may inform risk. The Natural History of APOL1-Associated Nephropathy Study (NHAANS) reported that urine JC polyomavirus (JCPyV) associated with a lower risk of APOL1-associated nephropathy in African Americans. Herein, association was assessed between urine JCPyV with CKD in African Americans independent from the APOL1 genotype. Methods: Quantitative polymerase chain reaction was performed for urinary detection of JCPyV and BK polyoma virus (BKPyV) in 200 newly recruited nondiabetic African Americans...
February 6, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29415751/when-participants-get-involved-reconsidering-patient-and-public-involvement-in-clinical-trials-at-the-mrc-clinical-trials-unit-at-ucl
#15
Claire L Vale, William J Cragg, Ben Cromarty, Bec Hanley, Annabelle South, Richard Stephens, Kate Sturgeon, Mitzy Gafos
BACKGROUND: Patient and public involvement (PPI) in clinical trials aims to ensure that research is carried out collaboratively with patients and/or members of the public. However, current guidance on involving clinical trial participants in PPI activities is not consistent. METHODS: We reviewed the concept of participant involvement, based on our experience. Two workshops were held at the MRCCTU at UCL with the aim of defining participant involvement, considering its rationale; benefits and challenges; and identifying appropriate models for participant involvement in clinical trials...
February 7, 2018: Trials
https://www.readbyqxmd.com/read/29407653/adaptive-forecasting-of-phytoplankton-communities
#16
Trevor Page, Paul J Smith, Keith J Beven, Ian D Jones, J Alex Elliott, Stephen C Maberly, Eleanor B Mackay, Mitzi De Ville, Heidrun Feuchtmayr
The global proliferation of harmful algal blooms poses an increasing threat to water resources, recreation and ecosystems. Predicting the occurrence of these blooms is therefore needed to assist water managers in making management decisions to mitigate their impact. Evaluation of the potential for forecasting of algal blooms using the phytoplankton community model PROTECH was undertaken in pseudo-real-time. This was achieved within a data assimilation scheme using the Ensemble Kalman Filter to allow uncertainties and model nonlinearities to be propagated to forecast outputs...
May 1, 2018: Water Research
https://www.readbyqxmd.com/read/29395698/response-to-the-hammoud-et-al-paper-on-the-new-mtv-generation
#17
Mitzy Gafos, Julie Chas, Gilles Pialoux
No abstract text is available yet for this article.
January 29, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29392733/the-role-of-gut-microbiome-and-associated-metabolome-in-the-regulation-of-neuroinflammation-in-multiple-sclerosis-and-its-implications-in-attenuating-chronic-inflammation-in-other-inflammatory-and-autoimmune-disorders
#18
REVIEW
Nicholas Dopkins, Prakash S Nagarkatti, Mitzi Nagarkatti
The importance of the gut microbiome in the regulation of non-infectious diseases has earned unprecedented interest from biomedical researchers. Widespread use of next-generation sequencing techniques has prepared a foundation for further research by correlating the presence of specific bacterial species with the onset or severity of a disease state, heralding paradigm-shifting results. This review covers the mechanisms through which a dysbiotic gut microbiota contributes to the pathological symptoms in an autoimmune neurodegenerative disorder, multiple sclerosis (MS)...
February 2, 2018: Immunology
https://www.readbyqxmd.com/read/29384661/charged-metallopolymer-grafted-silica-nanoparticles-for-antimicrobial-applications
#19
Parasmani Pageni, Peng Yang, Yung Pin Chen, Yucheng Huang, Marpe Bam, Tianyu Zhu, Mitzi Nagarkatti, Brian C Benicewicz, Alan W Decho, Chuanbing Tang
Inappropriate and frequent use of antibiotics has led to the development of antibiotic-resistant bacteria, which cause infectious diseases that are difficult to treat. With the rising threat of antibiotic resistance, the need to develop effective new antimicrobial agents is prominent. We report antimicrobial metallopolymer nanoparticles, which were prepared by surface-initiated reversible addition-fragmentation chain transfer polymerization of a cobaltocenium-containing methacrylate monomer from silica nanoparticles...
February 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29249164/effect-of-river-water-exposition-on-adhesion-and-invasion-abilities-of-salmonella-oranienburg-and-saintpaul
#20
Mitzi Dayanira Estrada-Acosta, Karina Ramirez, José Andrés Medrano-Félix, Nohelia Castro-Del Campo, Hector S López-Moreno, Maribel Jimenez Edeza, Jaime Martínez-Urtaza, Cristóbal Chaidez
This study was performed to evaluate in vitro the adherence and invasiveness capacity of Salmonella Oranienburg and Saintpaul (isolated from river water) exposed to laboratory and river water growth conditions and inoculated into epithelial HEp-2 cell. Results showed that Salmonella Oranienburg and Salmonella Saintpaul showed lower ability to adhere and invade epithelial HEp-2 cells under both growth conditions as compared to Salmonella Typhimurium reference strain. S. Oranienburg adhesion capacity was not affected by the growth conditions, while S...
February 2018: International Journal of Environmental Health Research
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