Yoshishige Urata, Yoshito Ihara, Hiroaki Murata, Shinji Goto, Takehiko Koji, Junji Yodoi, Satoshi Inoue, Takahito Kondo
The GSH/glutaredoxin (GRX) system is involved in the redox regulation of certain enzyme activities, and this system protects cells from H2O2-induced apoptosis by regulating the redox state of Akt (Murata, H., Ihara, Y., Nakamura, H., Yodoi, J., Sumikawa, K., and Kondo, T. (2003) J. Biol. Chem. 278, 50226-50233). Estrogens, such as 17beta-estradiol (E2), play an important role in development, growth, and differentiation and appear to have protective effects on oxidative stress mediated by estrogen receptor alpha (ERalpha)...
May 12, 2006: Journal of Biological Chemistry