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https://www.readbyqxmd.com/read/29758105/transcriptional-profiling-of-eosinophil-subsets-in-interleukin-5-transgenic-mice
#1
Kirsten A Fairfax, Jessica E Bolden, Aaron J Robinson, Erin C Lucas, Tracey M Baldwin, Kerry A Ramsay, Rebecca Cole, Douglas J Hilton, Carolyn A de Graaf
Eosinophils are important in fighting parasitic infections and are implicated in the pathogenesis of asthma and allergy. IL-5 is a critical regulator of eosinophil development, controlling proliferation, differentiation, and maturation of the lineage. Mice that constitutively express IL-5 have in excess of 10-fold more eosinophils in the hematopoietic organs than their wild type (WT) counterparts. We have identified that much of this expansion is in a population of Siglec-F high eosinophils, which are rare in WT mice...
May 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29755466/controlling-mast-cell-activation-and-homeostasis-work-influenced-by-bill-paul-that-continues-today
#2
REVIEW
Heather L Caslin, Kasalina N Kiwanuka, Tamara T Haque, Marcela T Taruselli, H Patrick MacKnight, Anuya Paranjape, John J Ryan
Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29751492/aluminum-adjuvant-containing-vaccines-in-the-context-of-the-hygiene-hypothesis-a-risk-factor-for-eosinophilia-and-allergy-in-a-genetically-susceptible-subpopulation
#3
REVIEW
Todd D Terhune, Richard C Deth
There are similarities between the immune response following immunization with aluminum adjuvants and the immune response elicited by some helminthic parasites, including stimulation of immunoglobulin E (IgE) and eosinophilia. Immunization with aluminum adjuvants, as with helminth infection, induces a Th2 type cell mediated immune response, including eosinophilia, but does not induce an environment conducive to the induction of regulatory mechanisms. Helminths play a role in what is known as the hygiene hypothesis, which proposes that decreased exposure to microbes during a critical time in early life has resulted in the increased prevalence and morbidity of asthma and atopic disorders over the past few decades, especially in Western countries...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29651227/a-case-of-atopic-dermatitis-caused-by-ascaris-lumbricoides-infection
#4
Rosanna Qualizza, Laura M Losappio, Fabiana Furci
Background: Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as Ascaris lumbricoides infection. Ascaris lumbricoides is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Patients with ascaridiasis and high IgE levels may also have allergy-like symptoms such as asthma, urticaria and atopic dermatitis...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29617393/cost-and-economic-burden-of-illness-over-15-years-in-nepal-a-comparative-analysis
#5
Khin Thet Swe, Md Mizanur Rahman, Md Shafiur Rahman, Eiko Saito, Sarah K Abe, Stuart Gilmour, Kenji Shibuya
BACKGROUND: With an increasing burden of non-communicable disease in Nepal and limited progress towards universal health coverage, country- and disease-specific estimates of financial hardship related to healthcare costs need to be evaluated to protect the population effectively from healthcare-related financial burden. OBJECTIVES: To estimate the cost and economic burden of illness and to assess the inequality in the financial burden due to catastrophic health expenditure from 1995 to 2010 in Nepal...
2018: PloS One
https://www.readbyqxmd.com/read/29588070/parasite-allergens
#6
Luis Caraballo, Sandra Coronado
Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infections is intriguing that they are not usually associated with allergic symptoms, which probably (but not exclusively) depends on parasite-induced immunomodulation. However, allergic manifestations have been described during some helminth infections such as ascariasis, strongyloidiasis, anisakiasis and hydatidosis...
March 24, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29540770/il-33-st2-signalling-and-crosstalk-with-fc%C3%AE%C2%B5ri-and-tlr4-is-targeted-by-the-parasitic-worm-product-es-62
#7
Dimity H Ball, Lamyaa Al-Riyami, William Harnett, Margaret M Harnett
ES-62 is a secreted parasitic worm-derived immunomodulator that exhibits therapeutic potential in allergy by downregulating aberrant MyD88 signalling to normalise the inflammatory phenotype and mast cell responses. IL-33 plays an important role in driving mast cell responses and promoting type-2 allergic inflammation, particularly with respect to asthma, via MyD88-integrated crosstalk amongst the IL-33 receptor (ST2), TLR4 and FcεRI. We have now investigated whether ES-62 targets this pathogenic network by subverting ST2-signalling, specifically by characterising how the functional outcomes of crosstalk amongst ST2, TLR4 and FcεRI are modulated by the worm product in wild type and ST2-deficient mast cells...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29522851/the-parasitic-68-mer-peptide-fhhdm-1-inhibits-mixed-granulocytic-inflammation-and-airway-hyperreactivity
#8
Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P Dalton, Simon Phipps, Maria B Sukkar, Sheila Donnelly
No abstract text is available yet for this article.
March 6, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29417217/dew-point-temperature-affects-ascospore-release-of-allergenic-genus-leptosphaeria
#9
Magdalena Sadyś, Joanna Kaczmarek, Agnieszka Grinn-Gofron, Victoria Rodinkova, Alex Prikhodko, Elena Bilous, Agnieszka Strzelczak, Robert J Herbert, Malgorzata Jedryczka
The genus Leptosphaeria contains numerous fungi that cause the symptoms of asthma and also parasitize wild and crop plants. In search of a robust and universal forecast model, the ascospore concentration in air was measured and weather data recorded from 1 March to 31 October between 2006 and 2012. The experiment was conducted in three European countries of the temperate climate, i.e., Ukraine, Poland, and the UK. Out of over 150 forecast models produced using artificial neural networks (ANNs) and multivariate regression trees (MRTs), we selected the best model for each site, as well as for joint two-site combinations...
January 27, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29399438/type-2-cytokine-responses-regulating-immunity-to-helminth-parasites-and-allergic-inflammation
#10
Everett K Henry, Juan M Inclan-Rico, Mark C Siracusa
Purpose of Review: It is well established that T helper type 2 (TH 2) immune responses are necessary to provide protection against helminth parasites but also to promote the detrimental inflammation associated with allergies and asthma. Given the importance of type 2 immunity and inflammation, many studies have focused on better understanding the factors that regulate TH 2 cell development and activation. As a result, significant progress has been made in understanding the signaling pathways and molecular events necessary to promote TH 2 cell polarization...
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29339033/helminth-modulation-of-lung-inflammation
#11
REVIEW
Christian Schwartz, Emily Hams, Padraic G Fallon
Parasitic helminths must establish chronic infections to complete their life cycle and therefore are potent modulators of multiple facets of host physiology. Parasitic helminths have coevolved with humans to become arguably master selectors of our immune system, whereby they have impacted on the selection of genes with beneficial mutations for both host and parasite. While helminth infections of humans are a significant health burden, studies have shown that helminths or helminth products can alter susceptibility to unrelated infectious or inflammatory diseases...
May 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29163443/parasite-derived-proteins-for-the-treatment-of-allergies-and-autoimmune-diseases
#12
REVIEW
Zhenyu Wu, Lifu Wang, Yanlai Tang, Xi Sun
The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29153708/pathophysiology-of-il-33-and-il-17-in-allergic-disorders
#13
REVIEW
Rinkesh Kumar Gupta, Kriti Gupta, Premendra D Dwivedi
Allergic diseases are among common clinical conditions, affecting millions of children and adults throughout the world. Food allergies, skin allergies (atopic dermatitis), and respiratory allergies (allergic rhinitis and asthma) are the common types of allergies. Recently discovered cytokines IL-17 and IL-33 have been found to play an important role in the pathogenicity of various hypersensitive disorders. After exposure to allergens or infection with parasites or viruses, IL-17 and IL-33 producing cells, such as Th17 and specialized epithelial cells respectively, become activated and trigger the pathogenic immune responses in different susceptible conditions...
December 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29062711/strongyloides-hyperinfection-syndrome-causing-fatal-meningitis-and-septicemia-by-citrobacter-koseri
#14
Felix Reyes, Navneet Singh, Nigar Anjuman-Khurram, Jihae Lee, Lillian Chow
Citrobacter koseri is a gram-negative bacillius that belongs to the Enterobacteriaceae family. It is an uncommon pathogen that typically causes meningitis and brain abscesses in children, however central nervous system (CNS) infections are rarely found in adults. We present a case of C. koseri meningitis in an immunocompetent adult secondary to intestinal micro-perforation caused by Strongyloides A 76-year-old man admitted for asthma exacerbation developed septic shock. A lumbar puncture revealed bacterial meningitis...
2017: IDCases
https://www.readbyqxmd.com/read/28957644/effect-of-early-life-geohelminth-infections-on-the-development-of-wheezing-at-5-years-of-age
#15
Philip J Cooper, Martha E Chico, Maritza G Vaca, Carlos A Sandoval, Sofia Loor, Leila D Amorim, Laura C Rodrigues, Mauricio L Barreto, David P Strachan
RATIONALE: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. OBJECTIVES: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. METHODS: A cohort of 2,404 neonates was followed to 5 years of age in a rural district in coastal Ecuador. Data on wheeze were collected by questionnaire and atopy was measured by allergen skin prick test reactivity to 10 allergens at 5 years...
February 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28952282/activation-and-inhibition-of-adaptive-immune-response-mediated-by-mast-cells
#16
REVIEW
E Toniato, I Frydas, I Robuffo, G Ronconi, Al Caraffa, S K Kritas, P Conti
Adaptive immune response plays an important role against bacteria and parasites, a reaction that also involves mast cell (MC) activation which participates in innate and adaptive immunity. In allergic reactions there is a TH2 immune response with generation of allergen-specific IgE antibodies. In MCs, IgE cross-link FcRI high affinity receptor and activate tyrosine kinase proteins, leading to stimulation of NF-κB and AP-1 resulting in the release of a number of cytokines/chemokines and other compounds. Through their proteolytic pathways, MCs may process the antigen for presentation to CD4+ cells which release TH2 cytokines and growth factors, which play an important role in asthma, allergy, anaphylaxis and inflammation...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28912783/sex-differences-in-asthma-a-key-role-of-androgen-signaling-in-group-2-innate-lymphoid-cells
#17
REVIEW
Sophie Laffont, Eve Blanquart, Jean-Charles Guéry
Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in men. However, heightened immunity in women makes them more susceptible than men to autoimmunity and allergy. While sex differences in immunity are well documented, little is known about the cellular and molecular mechanisms underlying these immunological differences, particularly in allergic asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28815724/secreted-products-of-fasciola-hepatica-inhibit-the-induction-of-t-cell-responses-that-mediate-allergy
#18
C M Finlay, A M Stefanska, M M Coleman, H Jahns, J P Cassidy, R M McLoughlin, K H G Mills
There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica (FHES) protected mice against ovalbumin (OVA)-induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen-challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways...
October 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28770202/cysteinyl-leukotrienes-in-eosinophil-biology-functional-roles-and-therapeutic-perspectives-in-eosinophilic-disorders
#19
REVIEW
Glaucia A Thompson-Souza, Isabella Gropillo, Josiane S Neves
Cysteinyl leukotrienes (cysLTs), LTC4, and its extracellular metabolites, LTD4 and LTE4, have varied and multiple roles in mediating eosinophilic disorders including host defense against parasitic helminthes and allergic inflammation, especially in the lung and in asthma. CysLTs are known to act through at least 2 receptors termed cysLT1 receptor (CysLT1R) and cysLT2 receptor (CysLT2R). Eosinophils contain a dominant population of cytoplasmic crystalloid granules that store various preformed proteins. Human eosinophils are sources of cysLTs and are known to express the two known cysLTs receptors (CysLTRs)...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28704396/phenotypic-chemical-and-functional-characterization-of-cyclic-nucleotide-phosphodiesterase-4-pde4-as-a-potential-anthelmintic-drug-target
#20
Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock, Maliwan Meewan, Alberto A Rascón, Lin Lin, Katherine A Cunningham, George A Lemieux, Larissa Podust, Ruben Abagyan, Kaveh Ashrafi, James H McKerrow, Conor R Caffrey
BACKGROUND: Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications including asthma, chronic obstructive pulmonary disease and Alzheimer's disease. One class of huPDE4 inhibitors that has yielded marketed drugs is the benzoxaboroles (Anacor Pharmaceuticals)...
July 2017: PLoS Neglected Tropical Diseases
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