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https://www.readbyqxmd.com/read/28437952/real-time-observation-of-round-trip-resolved-spectral-dynamics-in-a-stabilized-fs-fiber-laser
#1
Bowen Li, Ying Yu, Xiaoming Wei, Yiqing Xu, Kevin K Tsia, Kenneth K Y Wong
Fiber-stretcher based phase-lock loop (PLL) is a mature technique in fiber mode-locked lasers for repetition-rate stabilization. However, undesired side effects may be induced if not properly handled, which is easily overlooked owing to the lack of single-shot spectral analyzers. Thanks to the ultrafast spectral analyzing capability of optical time-stretch, an intriguing spectral dynamics is observed in a repetition-rate-stabilized nonlinear polarization rotation (NPR) mode-locked laser. Under the dynamic state, the optical spectra of pulses undergo dramatic evolution in every round trip while the pulse energy is relatively constant...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437942/optical-damage-resistant-ti-diffused-zr-er-codoped-lithium-niobate-strip-waveguide-for-high-power-980-nm-pumping
#2
Wen-Bao Sun, Xiao-Fei Yang, Zi-Bo Zhang, Wing-Han Wong, Dao-Yin Yu, Edwin Yue-Bun Pun, De-Long Zhang
Ti<sup>4+</sup>-diffused Zr<sup>4+</sup>/Er<sup>3+</sup>-codoped LiNbO<sub>3</sub> strip waveguide was fabricated on an X-cut LiNbO<sub>3</sub> substrate by thermal diffusion in sequence of Er<sup>3+</sup>, Zr<sup>4+</sup> and Ti<sup>4+</sup>. Secondary ion mass spectrometry study shows that the Ti<sup>4+</sup> ions follow a sum of two error functions in the width direction and a Gauss function in the depth direction of the waveguide...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437764/the-use-of-lithium-for-the-treatment-of-bipolar-disorder-recommendations-from-clinical-practice-guidelines
#3
Gin S Malhi, Danielle Gessler, Tim Outhred
BACKGROUND: Lithium is an effective mood stabilizer that is used principally for the management of bipolar disorder (BD). Its administration is complex and often requires sophisticated management and assiduous monitoring. When considering the use of lithium therapy for bipolar disorder, clinicians are advised to refer to recommendations outlined in clinical practice guidelines (CPGs); but because of varying emphases placed by different international CPGs, recommendations addressing the practical use of lithium lack consistency...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28437753/p-gp-modulatory-acetyl-11-keto-%C3%AE-boswellic-acid-based-nanoemulsified-carrier-system-for-augmented-oral-chemotherapy-of-docetaxel
#4
Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra
In spite of being a very potent and promising drug against many types of cancer, docetaxel suffers the disadvantage of low solubility and poor bioavailability rendering it unsuitable for oral administration. Also, the available marketed formulation for intravenous administration has its inherent drawbacks owing to the presence of polysorbate 80. Here, we exploited the anticancer and P-gp inhibitory potential of naturally occurring frankincense oil to fabricate a stable docetaxel loaded nanoemulsified carrier system for oral delivery...
April 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28437742/biological-treatment-of-model-dyes-and-textile-wastewaters
#5
Alicia Paz, Julia Carballo, María José Pérez, José Manuel Domínguez
Previous works conducted in our laboratory, reveled that Bacillus aryabhattai DC100 produce ligninolytic enzymes such as laccases and/or peroxidases, opening new applications in different bioprocesses, including the treatment of disposal residues such as dyestuffs from textile processing industries. This work described the degradation of three commercial model dyes Coomassie Brilliant Blue G-250 (CBB), Indigo Carmine (IC) and Remazol Brilliant Blue R (RBBR) under different culture media and operational conditions...
April 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437721/optimizing-follow-up-and-study-retention-in-the-21st-century-advances-from-the-front-line-in-alcohol-and-tobacco-research
#6
Lia J Smith, Patrick J McNamara, Andrea C King
AIMS: Longitudinal studies are integral in addiction research but retention of participants over time can be challenging. While statistical algorithms for missing data have advanced, they remain less desirable than collecting actual data with high retention rates. An update to methodological primers with consideration of evolving technology and privacy concerns is needed for 21st century researchers. METHODS: Comprehensive follow-up methodological strategies were conducted in four concurrent laboratory- and intervention-based studies across N=697 drinker and smokers enrolled in studies at the Clinical Addictions Research Laboratory at the University of Chicago...
April 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28437710/customised-nucleic-acid-libraries-for-enhanced-aptamer-selection-and-performance
#7
REVIEW
Franziska Pfeiffer, Malte Rosenthal, Julia Siegl, Jörg Ewers, Günter Mayer
Aptamers are short single-stranded oligo(deoxy)nucleotides that are selected to bind to target molecules with high affinity and specificity. Because of their sophisticated characteristics and versatile applicability, aptamers are thought to become universal molecular probes in biotechnological and therapeutic applications. However, the variety of possible interactions with a putative target molecule is limited by the chemical repertoire of the natural nucleobases. Consequently, many desired targets are not addressable by aptamers...
April 21, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#8
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28437511/online-information-on-the-treatment-of-burning-mouth-syndrome-quality-and-readability
#9
Shatha Alnafea, Stefano Fedele, Stephen Porter, Richeal Ni Riordain
AIMS: To evaluate the quality and readability of online information about the treatment of burning mouth syndrome (BMS). METHODS: An internet search using the phrase "burning mouth syndrome treatment" was carried out on the Google search engine (www.google.co.uk) on 8 June 2015, and the first 100 websites listed were examined. Data collection included DISCERN score, the Journal of the American Medical Association (JAMA) benchmarks for website analysis score, the presence of the Health on the Net (HON) Foundation seal, and the Flesch Reading Ease Score (FRES)...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437495/a-practical-guide-to-understanding-and-treating-patellofemoral-pain
#10
John P Fulkerson
There is no shortcut to accurate diagnosis in the patellofemoral pain patient. Most important in the process is a desire and ability to specifically identify the structural and biomechanical origin of pain. This can be elusive and often requires a careful analysis of all factors affecting the patient, including documenting his or her specific history of pain origin and specific treatments to date, and acknowledging the patient's localization of the pain origin. Many patients can pinpoint the site of pain origin when given the time and encouragement to do so...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437205/-she-would-be-flailing-around-distressed-the-critical-role-of-home-based-palliative-care-for-patients-with-advanced-cancer
#11
Brook A Calton, Nicole Thompson, Nancy Shepard, Redwing Keyssar, Kanan Patel, Virginia Dzul-Church, Helen Kao, Christine Ritchie, Michael W Rabow
BACKGROUND: Patients with advanced cancer experience significant symptoms, ineffective treatments, and hospice underutilization. Home-based palliative care (HBPC) may fill a service gap for patients who require intensive home management, but are not enrolled in hospice. Even as data emerge on the utilization impacts of HBPC, other impacts are not as well known. METHODS: We describe findings of a pilot project in HBPC, Community Bridges (CB), for patients with advanced cancer...
February 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28437104/redox-active-macrocycles-for-organic-rechargeable-batteries
#12
Dong Jun Kim, Keith R Hermann, Aleksandrs Prokofjevs, Michael T Otley, Cristian Pezzato, Magdalena Owczarek, J Fraser Stoddart
Organic rechargeable batteries, composed of redox-active molecules, are emerging as candidates for the next generation of energy storage materials because of their large specific capacities, cost effectiveness, and the abundance of organic precursors, when compared with conventional lithium-ion batteries. Although redox-active molecules often display multiple redox states, precise control of a molecule's redox potential, leading to a single output voltage in a battery, remains a fundamental challenge in this popular field of research...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28437096/importance-of-mm-polarization-in-qm-mm-studies-of-enzymatic-reactions-assessment-of-the-qm-mm-drude-oscillator-model
#13
Abir Ganguly, Eliot Boulanger, Walter Thiel
For accurate quantum mechanics/molecular mechanics (QM/MM) studies of enzymatic reactions, it is desirable to include MM polarization, for example by using the Drude oscillator (DO) model. For a long time, such studies were hampered by the lack of well-tested polarizable force fields for proteins. Following up on a recent preliminary QM/MM-DO assessment (J. Chem. THEORY: Comput. 2014, 10, 1795-1809) we now report a comprehensive investigation of the effects of MM polarization on two enzymatic reactions, namely the Claisen rearrangement in chorismate mutase and the hydroxylation reaction in p-hydroxybenzoate hydrolase, using the QM/CHARMM-DO model and two QM methods (B3LYP, OM2)...
April 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28437091/speeding-up-early-drug-discovery-in-antiviral-research-a-fragment-based-in-silico-approach-for-the-design-of-virtual-anti-hepatitis-c-leads
#14
Alejandro Speck-Planche, M Natalia Dias Soeiro Cordeiro
Hepatitis C constitutes an unresolved global health problem. This infectious disease is caused by the hepatotropic hepatitis C virus (HCV), and it can lead to the occurrence of life-threatening medical conditions such as cirrhosis and liver cancer. Nowadays, major clinical concerns have arisen due to the appearance of multidrug resistance (MDR), and the side effects especially associated with long-term treatments. In this work, we report the first multitasking model for quantitative structure-biological effect relationships (mtk-QSBER), focused on the simultaneous exploration of anti-HCV activity and in vitro safety profiles related to the absorption, distribution, metabolism, elimination, and toxicity (ADMET)...
April 24, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28437070/large-scale-synthesis-of-carbon-shell-coated-fep-nanoparticles-for-robust-hydrogen-evolution-reaction-electrocatalyst
#15
Dong Young Chung, Samuel Woojoo Jun, Gabin Yoon, Hyunjoong Kim, Ji Mun Yoo, Kug-Seung Lee, Taehyun Kim, Heejong Shin, Arun Kumar Sinha, Soon Gu Kwon, Kisuk Kang, Taeghwan Hyeon, Yung-Eun Sung
Highly active and stable non-Pt electrocatalyst for hydrogen production has been pursed for a long time as alternative of expensive Pt catalyst. Herein we report a simple and effective approach to prepare highly stable iron phosphide (FeP) nanoparticle electrocatalyst using iron oxide nanoparticles as the precursor. A single step heating procedure of polydopamine-coated iron oxide nanoparticles leads to carbonization of dopamine coating to carbon shell and phosphidation of iron oxide to FeP, simultaneously...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28436922/the-feasibility-of-manual-parameter-tuning-for-deformable-breast-mr-image-registration-from-a-multi-objective-optimization-perspective
#16
Kleopatra Pirpinia, Peter Bosman, Claudette Loo, Gonneke Winter-Warnars, Natasja Janssen, Astrid Scholten, Jan-Jakob Sonke, Marcel van Herk, Tanja Alderliesten
Deformable image registration is typically formulated as an optimization problem involving a linearly weighted combination of terms that correspond to objectives of interest (e.g., similarity, deformation magnitude). The weights, along with multiple other parameters, need to be manually tuned for each application, a task currently mainly addressed via trial-and-error approaches. Such approaches can only be successful if there is a sensible interplay between parameters, objectives, and desired registration outcome...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436906/nonlinear-decoupling-control-with-anfis-based-unmodeled-dynamics-compensation-for-a-class-of-complex-industrial-processes
#17
Yajun Zhang, Tianyou Chai, Hong Wang, Dianhui Wang, Xinkai Chen
Complex industrial processes are multivariable and generally exhibit strong coupling among their control loops with heavy nonlinear nature. These make it very difficult to obtain an accurate model. As a result, the conventional and data-driven control methods are difficult to apply. Using a twin-tank level control system as an example, a novel multivariable decoupling control algorithm with adaptive neural-fuzzy inference system (ANFIS)-based unmodeled dynamics (UD) compensation is proposed in this paper for a class of complex industrial processes...
April 24, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28436903/robust-multiview-data-analysis-through-collective-low-rank-subspace
#18
Zhengming Ding, Yun Fu
Multiview data are of great abundance in real-world applications, since various viewpoints and multiple sensors desire to represent the data in a better way. Conventional multiview learning methods aimed to learn multiple view-specific transformations meanwhile assumed the view knowledge of training, and test data were available in advance. However, they would fail when we do not have any prior knowledge for the probe data's view information, since the correct view-specific projections cannot be utilized to extract effective feature representations...
April 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28436899/adaptive-backstepping-based-neural-tracking-control-for-mimo-nonlinear-switched-systems-subject-to-input-delays
#19
Ben Niu, Lu Li
This brief proposes a new neural-network (NN)-based adaptive output tracking control scheme for a class of disturbed multiple-input multiple-output uncertain nonlinear switched systems with input delays. By combining the universal approximation ability of radial basis function NNs and adaptive backstepping recursive design with an improved multiple Lyapunov function (MLF) scheme, a novel adaptive neural output tracking controller design method is presented for the switched system. The feature of the developed design is that different coordinate transformations are adopted to overcome the conservativeness caused by adopting a common coordinate transformation for all subsystems...
April 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28436890/in-situ-force-augmentation-improves-surface-contact-and-force-control
#20
Randy Lee, Roberta Klatzky, George Stetten
Surgeons routinely perform surgery with noisy, sub-threshold, or obscured visual and haptic feedback, either due to the necessary surgical approach, or because the systems on which they are operating are exceedingly delicate. Technological solutions incorporating haptic feedback augmentation have been proposed to address these difficulties, but the consequences for motor control have not been directly investigated and quantified. In this paper, we present two isometric force generation tasks performed with a hand-held robotic tool that provides in-situ augmentation of force sensation...
April 24, 2017: IEEE Transactions on Haptics
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