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https://www.readbyqxmd.com/read/28092639/lithographic-patterning-of-antibodies-by-direct-lift-off-and-improved-surface-adhesion
#1
Sankalp Verma, Vivek Verma
The inherent property of antibodies binding to their antigen with high specificity makes them a strong candidate for sensing and detection applications. Microscale patterning of antibodies is desired for the miniaturization of sensors and fundamental cell biology studies. However, existing methodologies to pattern antibodies at the microscale are multi-step. In this work, we demonstrate microscale patterning of antibodies on a glass coverslip in a single step photolithography process. The microscale features of the photoresist were generated on the coverslip using photolithography, and the antibody solution was incubated...
January 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28092550/-l_0-gradient-projection
#2
Shunsuke Ono
Minimizing L0 gradient, the number of the nonzero gradients of an image, together with a quadratic datafidelity to an input image has been recognized as a powerful edge-preserving filtering method. However, the L0 gradient minimization has an inherent difficulty: a user-given parameter controlling the degree of flatness does not have a physical meaning since the parameter just balances the relative importance of the L0 gradient term to the quadratic data-fidelity term. As a result, the setting of the parameter is a troublesome work in the L0 gradient minimization...
January 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092547/asymmetrically-compressed-stereoscopic-3d-videos-quality-assessment-and-rate-distortion-performance-evaluation
#3
Jiheng Wang, Shiqi Wang, Zhou Wang
Objective quality assessment of stereoscopic 3D video is challenging but highly desirable, especially in the application of stereoscopic video compression and transmission, where useful quality models are missing that can guide the critical decision making steps in the selection of mixed-resolution coding, asymmetric quantization, and pre- and post-processing schemes. Here we first carry out subjective quality assessment experiments on two databases that contain various asymmetrically compressed stereoscopic 3D videos obtained from mixed-resolution coding, asymmetric transform-domain quantization coding, their combinations, and multiple choices of postprocessing techniques...
January 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092464/expectations-for-treatment-in-pediatric-weight-management-and-relationship-to-attrition
#4
Erinn T Rhodes, Richard E Boles, Kimberly Chin, Amy Christison, Elizabeth Getzoff Testa, Kimberly Guion, Mary Jane Hawkins, Carter R Petty, Bethany Sallinen Gaffka, Melissa Santos, Laura Shaffer, Jared Tucker, Sarah E Hampl
BACKGROUND: Attrition in pediatric weight management negatively impacts treatment outcomes. A potentially modifiable contributor to attrition is unmet family expectations. This study aimed to evaluate the association between adolescent and parent/guardian treatment expectations and attrition. PATIENTS AND METHODS: A prospective, nonrandomized, uncontrolled, single-arm pilot trial was conducted among 12 pediatric weight management programs in the Children's Hospital Association's FOCUS on a Fitter Future collaborative...
January 16, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28092440/molecular-interactions-between-graphene-and-biological-molecules
#5
Xingquan Zou, Shuai Wei, Joshua Jasensky, Minyu Xiao, Qiuming Wang, Charles L Brooks, Zhan Chen
Applications of graphene have extended into areas of nanobio-technology such as nanobio-medicine, nanobio-sensing, as well as nanoelectronics with biomolecules. These applications involve interactions between proteins, peptides, DNA, RNA etc. and graphene, therefore understanding such molecular interactions is essential. For example, many applications based on using graphene and peptides require peptides to interact with (e.g., noncovalently bind to) graphene at one end, while simultaneously exposing the other end to the surrounding medium (e...
January 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28092437/3d-porous-nanoarchitectures-derived-from-sns-s-doped-graphene-hybrid-nanosheets-for-flexible-all-solid-state-supercapacitors
#6
Chunyan Liu, Shulin Zhao, Yanan Lu, Yingxue Chang, Dongdong Xu, Qi Wang, Zhihui Dai, Jianchun Bao, Min Han
3D porous nanoarchitectures derived from SnS/S-doped graphene hybrid nanosheets are successfully prepared by controllable thermal conversion of oleylamine-capped mixed-phase SnS2 -SnS nanodisks precursors, and employed as electroactive material to fabricate flexible, symmetric, all-solid-state supercapacitors. The fabricated solid devices exhibit very high areal specific capacitance (2.98 mF cm(-2) ), good cycling stability (99% for 10 000 cycles), excellent flexibility, and desirable mechanical stability.
January 16, 2017: Small
https://www.readbyqxmd.com/read/28092432/highly-ordered-nanoring-arrays-formed-by-templated-si-containing-triblock-terpolymer-thin-films
#7
Karim Aissou, Muhammad Mumtaz, Pierre Marcasuzaa, Cyril Brochon, Eric Cloutet, Guillaume Fleury, Georges Hadziioannou
Laterally ordered nanorings with a periodicity of 38 nm are produced from the directed self-assembly of poly(1,1-dimethylsilacyclobutane)-block-polystyrene-block-poly(methyl methacrylate) thin films on topographically patterned substrates. Such nanoscale arrays with vertically oriented rings are highly desired in technological applications including memory using magnetic recording, metamaterial, waveguide, etc.
January 16, 2017: Small
https://www.readbyqxmd.com/read/28092422/international-consensus-principles-for-ethical-wildlife-control
#8
Sara Dubois, Nicole Fenwick, Erin A Ryan, Liv Baker, Sandra E Baker, Ngaio J Beausoleil, Scott Carter, Barbara Cartwright, Federico Costa, Chris Draper, John Griffin, Adam Grogan, Gregg Howald, Bidda Jones, Kate E Littin, Amanda T Lombard, David J Mellor, Daniel Ramp, Catherine A Schuppli, David Fraser
Human-wildlife conflicts are commonly addressed by excluding, relocating, or lethally controlling animals with the goal of preserving public health and safety, protecting property, or conserving other valued wildlife. However, declining wildlife populations, a lack of efficacy of control methods in achieving desired outcomes, and changes in how people value animals have triggered widespread acknowledgment of the need for ethical and evidence-based approaches to managing such conflicts. We explored international perspectives on and experiences with human-wildlife conflicts to develop principles for ethical wildlife control...
January 16, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28092391/correlation-of-focal-adhesion-assembly-and-disassembly-with-cell-migration-on-nanotopography
#9
Elena I Liang, Emma J Mah, Albert F Yee, Michelle A Digman
Selective cell adhesion is desirable to control cell growth and migration on biomedical implants. Mesenchymal cell migration is regulated through focal adhesions (FAs) and can be modulated by their microenvironment, including changes in surface topography. We use the Number and Molecular Brightness (N&B) imaging analysis to provide a unique perspective on FA assembly and disassembly. This imaging analysis generates a map of real-time fluctuations of protein monomers, dimers, and higher order aggregates of FA proteins, such as paxillin during assembly and disassembly...
January 16, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28092358/recurrent-rna-motifs-as-scaffolds-for-genetically-encodable-small-molecule-biosensors
#10
Ely B Porter, Jacob T Polaski, Makenna M Morck, Robert T Batey
Allosteric RNA devices are increasingly being viewed as important tools capable of monitoring enzyme evolution, optimizing engineered metabolic pathways, facilitating gene discovery and regulators of nucleic acid-based therapeutics. A key bottleneck in the development of these platforms is the availability of small-molecule-binding RNA aptamers that robustly function in the cellular environment. Although aptamers can be raised against nearly any desired target through in vitro selection, many cannot easily be integrated into devices or do not reliably function in a cellular context...
January 16, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28092341/unilateral-spinous-process-non-covering-hook-type-patient-specific-drill-template-for-thoracic-pedicle-screw-fixation-a-pilot-clinical-trial-and-template-classification
#11
Sang Bum Kim, Yougun Won, Hyun Jin Yoo, Lee Jae Sin, John M Rhee, Sang Wook Lee, Gi-Soo Lee
STUDY DESIGN: Prospective Clinical Pilot tudy OBJECTIVE.: To confirm the accuracy of thoracic pedicle screw placement by using the unilateral spinous non-covering hook type patient-specific drill template (PSDT) made through rapid prototyping (RP) and to analyze previously reported PSDT designs and their characteristics. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is the most common form of the posterior instrumentation of the thoracic and lumbar spine. Various techniques have been introduced to improve pedicle screw placement...
January 13, 2017: Spine
https://www.readbyqxmd.com/read/28092192/do-i-feel-ill-because-i-crave-for-work-or-do-i-crave-for-work-because-i-feel-ill-a-longitudinal-analysis-of-work-craving-self-regulation-and-health
#12
Kamila Wojdylo, Wilhelm Karlsson, Nicola Baumann
Background The theory of work craving defines workaholism as a pathological work addiction which comprises: (a) obsessive-compulsive desire to work, (b) anticipation of self-worth compensatory incentives from working, (c) anticipation of reduction of negative emotions or withdrawal symptoms from working, and (d) neurotic perfectionism. Research has shown that workaholism is associated with adverse health outcomes. However, the antecedents of workaholism and the causal direction of the relationship with health have been largely neglected...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28092070/current-bioengineering-and-regenerative-strategies-for-the-generation-of-kidney-grafts-on-demand
#13
REVIEW
Ximo García-Domínguez, Jose S Vicente, Cesar D Vera-Donoso, Francisco Marco-Jimenez
Currently in the USA, one name is added to the organ transplant waiting list every 15 min. As this list grows rapidly, fewer than one-third of waiting patients can receive matched organs from donors. Unfortunately, many patients who require a transplant have to wait for long periods of time, and many of them die before receiving the desired organ. In the USA alone, over 100,000 patients are waiting for a kidney transplant. However, it is a problem that affects around 6% of the word population. Therefore, seeking alternative solutions to this problem is an urgent work...
January 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28091952/nanometric-cutting-of-silicon-with-an-amorphous-crystalline-layered-structure-a-molecular-dynamics-study
#14
Jinshi Wang, Fengzhou Fang, Xiaodong Zhang
Materials with specific nanometric layers are of great value in both theoretical and applied research. The nanometric layer could have a significant influence on the response to the mechanical loading. In this paper, the nanometric cutting on the layered systems of silicon has been studied by molecular dynamics. This kind of composite structure with amorphous layer and crystalline substrate is important for nanomachining. Material deformation, stress status, and chip formation, which are the key issues in nano-cutting, are analyzed...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28091949/nonmechanical-infrared-beam-steering-using-blue-addressed-quantum-dot-doped-liquid-crystal-grating
#15
Xiangru Wang, Xiaoping Huang, Ziqiang Huang, Liang Wu, Jiyang Shang, Qi Qiu, Shuanghong Wu
We present a scheme of nonmechanical laser beam steering using ZnS/InP quantum dots doping nematic liquid crystal as the optical recording film. Because of its internal electric field generated by blue laser-induced charge carrier distribution, liquid crystal molecules are reoriented to form a phase grating which make the incident angle steer to the angle as we desire. Being a nonmechanical programmable laser beam steering, the anisotropy of the relative permittivity tensor and blue laser-induced electric carriers play a significant effect in determining the reorientable liquid crystal molecule and reconfigurable phase modulation of the gratings, that determines the steering angle and steering efficiency...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28091859/cancer-genetic-counselors-current-practices-and-attitudes-related-to-the-use-of-tumor-profiling
#16
LeAnne Noelle Goedde, Nathan W Stupiansky, Melissa Lah, Kimberly A Quaid, Stephanie Cohen
Tumor profiling (TP) is primarily used to identify driver mutations within a tumor for treatment purposes, but it may also identify germline mutations. Current involvement of cancer genetic counselors (GCs) in the TP process is not clear. Members of the National Society of Genetic Counselors Cancer Special Interest Group were invited to participate in a confidential, web-based survey to characterize current practices and attitudes related to the use of TP. Of 105 useable responses, 86.7% of GCs reported their institutions were using TP, although only 6...
January 13, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28091847/using-the-newly-developed-floor-sitting-movement-analysis-proforma-to-study-the-effect-of-age-and-activity-on-floor-sitting-in-indian-adults
#17
Anjana Nagrajan, Sebestina A D'Souza
Floor-sitting is culturally relevant to the Indian context. The present study aimed to examine the effect of age and activity on the movement patterns used and time taken to perform floor-sitting in Indian adults. Video-recordings of 30 young (23.30 ± 2.53 years) and 30 older (69.67 ± 6.45 years) adults performing floor-sitting without and with an activity (simulated feeding) were analyzed using the Floor-sitting Movement Analysis Proforma (FMAP) developed for the study. For inter-rater reliability of the FMAP, two raters analyzed the performance of a random sample of 20 participants...
January 16, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28091611/multi-response-optimization-of-artemia-hatching-process-using-split-split-plot-design-based-response-surface-methodology
#18
V V Arun, Neelam Saharan, V Ramasubramanian, A M Babitha Rani, K R Salin, Ravindra Sontakke, Harsha Haridas, Deepak George Pazhayamadom
A novel method, BBD-SSPD is proposed by the combination of Box-Behnken Design (BBD) and Split-Split Plot Design (SSPD) which would ensure minimum number of experimental runs, leading to economical utilization in multi- factorial experiments. The brine shrimp Artemia was tested to study the combined effects of photoperiod, temperature and salinity, each with three levels, on the hatching percentage and hatching time of their cysts. The BBD was employed to select 13 treatment combinations out of the 27 possible combinations that were grouped in an SSPD arrangement...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091397/a-novel-stimulation-method-for-multi-class-ssvep-bci-using-intermodulation-frequencies
#19
Xiaogang Chen, Yijun Wang, Shangen Zhang, Shangkai Gao, Yong Hu, Xiaorong Gao
OBJECTIVE: Steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) has been widely investigated because of its easy system configuration, high information transfer rate (ITR) and little user training. However, due to the limitations of brain responses and the refresh rate of a monitor, the available stimulation frequencies for practical BCI application are generally restricted. APPROACH: This study introduced a novel stimulation method using intermodulation frequencies for SSVEP-BCIs that had targets flickering at the same frequency but with different additional modulation frequencies...
January 16, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28091341/correlation-between-infectious-disease-and-soil-radiation-in-japan-an-exploratory-study-using-national-sentinel-surveillance-data
#20
S Inaida, T Tsuda, S Matsuno
We investigated the relationship between epidemics and soil radiation through an exploratory study using sentinel surveillance data (individuals aged <20 years) during the last three epidemic seasons of influenza and norovirus in Japan. We used a spatial analysis method of a geographical information system (GIS). We mapped the epidemic spreading patterns from sentinel incidence rates. We calculated the average soil radiation [dm (μGy/h)] for each sentinel site using data on uranium, thorium, and potassium oxide in the soil and examined the incidence rate in units of 0·01 μGy/h...
January 16, 2017: Epidemiology and Infection
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