keyword
MENU ▼
Read by QxMD icon Read
search

Desire

keyword
https://www.readbyqxmd.com/read/27906451/proximity-dependent-biotinylation-for-identification-of-interacting-proteins
#1
Valerie Le Sage, Alessandro Cinti, Andrew J Mouland
Complex interaction networks orchestrate key cellular processes including but not limited to transcription, translation, metabolism, and cell signaling. Delineating these interactions will aid in deciphering the regulation and function of these pathways and potential for manipulation. Proximity-dependent biotin identification (BioID) is quickly gaining popularity as a powerful tool for identifying novel protein-protein and proximity-based interactions in live cells. This technique relies on a promiscuous biotin ligase, which is fused to a protein of interest and, upon expression in the desired cell, will biotinylate proximal endogenous proteins...
December 1, 2016: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/27906382/laser-patterned-functionalized-cvd-graphene-as-highly-transparent-conductive-electrodes-for-polymer-solar-cells
#2
Luca La Notte, Enrica Villari, Alessandro Lorenzo Palma, Alberto Sacchetti, Maria Michela Giangregorio, Giovanni Bruno, Aldo Di Carlo, Giuseppe Valerio Bianco, Andrea Reale
A five-layer (5L) graphene on a glass substrate has been demonstrated as a transparent conductive electrode to replace indium tin oxide (ITO) in organic photovoltaic devices. The required low sheet resistance, while maintaining high transparency, and the need of a wettable surface are the main issues. To overcome these, two strategies have been applied: (i) the p-doping of the multilayer graphene, thus reaching 25 Ω □(-1) or (ii) the O2-plasma oxidation of the last layer of the 5L graphene that results in a contact angle of 58° and a sheet resistance of 134 Ω □(-1)...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906370/optomechanical-oscillator-pumped-and-probed-by-optically-two-isolated-photonic-crystal-cavity-systems
#3
Feng Tian, Hisashi Sumikura, Eiichi Kuramochi, Hideaki Taniyama, Masato Takiguchi, Masaya Notomi
Optomechanical control of on-chip emitters is an important topic related to integrated all-optical circuits. However, there is neither a realization nor a suitable optomechanical structure for this control. The biggest obstacle is that the emission signal can hardly be distinguished from the pump light because of the several orders' power difference. In this study, we designed and experimentally verified an optomechanical oscillation system, in which a lumped mechanical oscillator connected two optically isolated pairs of coupled one-dimensional photonic crystal cavities...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906362/2-sup-16-sup-shades-of-gray-high-bit-depth-projection-using-light-intensity-control
#4
Jen-Hao Rick Chang, B V K Vijaya Kumar, Aswin C Sankaranarayanan
Projectors create grayscale images by outputting a series of bitplanes or binary images within a short time period. While this technique works well for projecting low bit-depth (8-bit) images, it becomes infeasible for high bit-depth (say, 16-bit) projection - a capability that is increasingly desirable in many applications including cinemas and gaming. Existing designs for high bit-depth projection rely on multiple spatial light modulators and, as a consequence, their costs and complexities are usually far beyond the average consumer...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906296/numerical-modeling-of-fiber-specklegram-sensors-by-using-finite-element-method-fem
#5
V H Arístizabal, F J Vélez, E Rueda, N D Gómez, J A Gómez
Although experimental advances in the implementation and characterization of fiber speckle sensor have been reported, a suitable model to interpret the speckle-pattern variation under perturbation is desirable but very challenging to be developed due to the various factors influencing the speckle pattern. In this work, a new methodology based on the finite element method (FEM) for modeling and optimizing fiber specklegram sensors (FSSs) is proposed. The numerical method allows computational visualization and quantification, in near field, of changes of a step multi-mode fiber (SMMF) specklegram, due to the application of a uniformly distributed force line (UDFL)...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906271/two-types-of-single-beam-deflection-and-asymmetric-transmission-in-photonic-structures-without-interface-corrugations
#6
Andriy E Serebryannikov, Evrim Colak, Thore Magath, Ekmel Ozbay
We study single-beam deflection and asymmetry in transmission, two aspects of the same phenomenon that appear in the topologically simple, nonsymmetric, photonic crystal (PhC)-based structures without corrugations at the interfaces. Strong diffractions enabling efficient blazing, i.e., redistribution of the incident wave energy in favor of the desired higher diffraction order(s), can be achieved owing to the defect-like layer(s) embedded in a regular slab of PhC. The main features, together with the peculiarities of the two basic transmission types and relevant coupling and deflection scenarios, are discussed, for one of which a part of the PhC works in the evanescent-wave regime...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27906268/upper-bound-of-signal-relevant-efficiency-of-constrained-diffractive-elements
#7
Antonie D Verhoeven, Harald Aagedal, Frank Wyrowski, Jari Turunen
We define the signal-relevant efficiency (SRE) of a diffractive optical element as a measure of the proportion of the incident field power that ends up in the desired output signal. An upper bound for SRE is determined in the presence of arbitrary constraints imposed on the element, such as phase-dependent loss due to absorption within the microstructure and quantization of the surface profile. We apply the theory to the important class of diffractive elements that contain only one desired diffraction order (such as diffractive lenses) and derive the surface profile that provides the highest efficiency allowed by the constraints...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27905970/a-feasibility-study-on-using-smartphones-to-conduct-short-version-verbal-autopsies-in-rural-china
#8
Jing Zhang, Rohina Joshi, Jixin Sun, Samantha R Rosenthal, Miao Tong, Cong Li, Rasika Rampatige, Meghan Mooney, Alan Lopez, Lijing L Yan
BACKGROUND: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking...
August 20, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905668/subconjunctival-antimicrobial-poloxamer-gel-for-treatment-of-corneal-ulceration-in-stranded-california-sea-lions-zalophus-californianus
#9
Claire A Simeone, Carmen M H Colitz, Kathleen M Colegrove, Cara L Field, Carlos Rios, Heather L Chandler, Shawn P Johnson
OBJECTIVE: Corneal ulcers are commonly encountered in pinnipeds. Prolonged oral antibiotics and topical ophthalmic solutions may not be practical to administer, and novel treatment techniques are desired. Thermodynamic gels are a potential solution because they hold antimicrobials at the site of injection, slowly releasing drug. This study investigated the clinical efficacy of antibiotic-impregnated poloxamer gel in management of corneal ulceration. ANIMAL STUDIED: Twenty-six California sea lions undergoing rehabilitation at The Marine Mammal Center...
December 1, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27905663/identifying-applicants-suitable-to-a-career-in-nursing-a-value-based-approach-to-undergraduate-selection
#10
Marian Traynor, Despina Galanouli, Martin Roberts, Lawrence Leonard, Thomas Gale
AIMS: To complement existing evidence on the suitability of Multiple Mini Interviews as potential tool for the selection of nursing candidates on to a BSc (Hons) nursing programme. BACKGROUND: This study aimed to trial the Multiple Mini Interview approach to recruitment with a group of first year nursing students (already selected using traditional interviews). DESIGN: Cross-sectional validation study. This paper reports on the evaluation of the participants' detailed scores from the Multiple Mini Interview stations; their original interview scores and their end of year results...
December 1, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27905594/open-ended-formulation-of-self-consistent-field-response-theory-with-the-polarizable-continuum-model-for-solvation
#11
Roberto Di Remigio, Maarten T P Beerepoot, Yann Cornaton, Magnus Ringholm, Arnfinn Hykkerud Steindal, Kenneth Ruud, Luca Frediani
The study of high-order absorption properties of molecules is a field of growing importance. Quantum-chemical studies can help design chromophores with desirable characteristics. Given that most experiments are performed in solution, it is important to devise a cost-effective strategy to include solvation effects in quantum-chemical studies of these properties. We here present an open-ended formulation of self-consistent field (SCF) response theory for a molecular solute coupled to a polarizable continuum model (PCM) description of the solvent...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905529/efficient-targeted-mutagenesis-of-rice-and-tobacco-genomes-using-cpf1-from-francisella-novicida
#12
Akira Endo, Mikami Masafumi, Hidetaka Kaya, Seiichi Toki
CRISPR/Cas9 systems are nowadays applied extensively to effect genome editing in various organisms including plants. CRISPR from Prevotella and Francisella 1 (Cpf1) is a newly characterized RNA-guided endonuclease that has two distinct features as compared to Cas9. First, Cpf1 utilizes a thymidine-rich protospacer adjacent motif (PAM) while Cas9 prefers a guanidine-rich PAM. Cpf1 could be used as a sequence-specific nuclease to target AT-rich regions of a genome that Cas9 had difficulty accessing. Second, Cpf1 generates DNA ends with a 5' overhang, whereas Cas9 creates blunt DNA ends after cleavage...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905467/direct-identification-of-antibiotic-resistance-genes-on-single-plasmid-molecules-using-crispr-cas9-in-combination-with-optical-dna-mapping
#13
Vilhelm Müller, Fredrika Rajer, Karolin Frykholm, Lena K Nyberg, Saair Quaderi, Joachim Fritzsche, Erik Kristiansson, Tobias Ambjörnsson, Linus Sandegren, Fredrik Westerlund
Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in nanofluidic channels, which provides detailed information about the plasmids present in a bacterial isolate. In a single experiment, we obtain the number of different plasmids in the sample, the size of each plasmid, an optical barcode that can be used to identify and trace the plasmid of interest and information about which plasmid that carries a specific resistance gene...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905078/improving-the-provision-of-otc-medication-information-in-community-pharmacies-in-poland
#14
Anna Piecuch, Magdalena Makarewicz-Wujec, Małgorzata Kozłowska-Wojciechowska
Background An informed or shared decision-making model is desirable to support the choice of over-the-counter (OTC) medications in pharmacies: it respects patient empowerment in self-medication. Such a model is achievable provided that pharmacists are a credible, competent information source open to patient needs. Objective To study the dependencies among selected factors that may influence the provision of OTC medication information. The study was conducted from the perspective of a community pharmacist. Method The study consisted of an auditorium survey with a self-administered questionnaire...
November 30, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27905077/improving-shared-decision-making-in-adolescents-through-antibiotic-education
#15
I W Ngadimon, F Islahudin, N Mohamed Shah, E Md Hatah, M Makmor-Bakry
Background Shared decision-making is vital in achieving desired drug therapy goals, especially with antibiotics, in view of the potential long-term reduction in drug resistance. However, shared decision-making is rarely practiced with adolescent patients. Objectives The aim of the study was to identify the effect antibiotic education has on willingness to engage in shared decision-making among adolescents in Malaysia. Setting Participants from secondary schools in Malaysia were enrolled with ethical approval...
November 30, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27904409/morphological-characterization-and-chemical-composition%C3%A2-of-fruits-of-the-traditional-croatian-chestnut-variety%C3%A2-lovran-marron
#16
Igor Poljak, Nada Vahčić, Milica Gačić, Marilena Idžojtić
'Lovran Marron' is the only known traditional Croatian variety of the sweet chestnut. The objective of this study is to specify qualitative and quantitative morphological characteristics and to analyze the chemical composition of the 'Lovran Marron' fruits as well as to compare them to Marušnjak fruits (trees from the 'Lovran Marron' seed) and fruits from the local natural sweet chestnut population. Seven morphological characteristics were measured: fruit mass, height, width and thickness, scar length and width, and the length of the longest intrusion of the seed coat into the kernel...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904170/twenty-five-year-old-woman-with-bilateral-borderline-ovarian-tumour-desiring-to-preserve-fertility-case-report-and-literature-review-on-the-current-state-of-fertility-preservation-in-women-with-borderline-ovarian-tumours
#17
S Findeklee, L Lotz, K Heusinger, I Hoffmann, R Dittrich, M W Beckmann
Borderline ovarian tumours are semimalignant tumours occurring unilaterally or bilaterally with a peak incidence among women of reproductive age. Since the affected women often wish to preserve fertility, particular precautions must be taken when counselling the patient and obtaining consent prior to planning an individual treatment. Options for preserving fertility include an organ-sparing surgical procedure and cryopreservation of oocytes and/or ovarian tissue. In this article, we report on a 25-year-old patient with a bilateral seromucinous borderline tumour who desired all fertility-preserving options...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27904168/care-situation-for-female-victims-of-sexual-violence-in-metropolitan-emergency-departments-with-charit%C3%A3-berlin-as-an-example
#18
H Hoffmann-Walbeck, M Möckel, S Etzold, M David
of the perpetrators were friends or relations; 17 % were (ex-)partners. The waiting time in the Charité emergency departments amounted to 58 minutes on average, the medical treatment time 55 minutes. About 80 % of the personnel evaluated the "stuprum kit" as being altogether good or very good. More than ⅓ considered the time and room conditions as being unsuitable or rather unsuitable for the situation. Two thirds expressed the desire for further training and supervision. Conclusion: The structured procedure by means of the "stuprum kit" has proved its value...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27904079/application-of-response-surface-methodology-to-estimate-the-design-space-of-pharmaceutical-diluents-for-dispensing-powdered-formulations
#19
Yasunori Miyazaki, Kozo Takayama, Tomonobu Uchino, Yoshiyuki Kagawa
Scientific approaches for dispensation are important for the quality and efficacy of drug treatments. Therefore, for the dispensation of powdered medicines, we have developed a powder blending method using a planetary centrifugal mixer (PCM) to replace the empirical manual method involving a mortar and pestle. The aim of this study was to optimize the formulation of pharmaceutical diluents for dispensing powdered medicines, using PCM. The diluents, composed of powdered lactose, crystalline lactose, and corn starch were assigned to a {3,2}-Simplex Lattice design...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27904030/formulation-optimization-and-in-vitro-characterization-of-orally-disintegrating-films-using-a-factorial-design-and-mathematical-modeling-for-drug-release
#20
Yeongbin Lee, Prakash Thapa, Seong Hoon Jeong, Mi Hee Woo, Du Hyung Choi
Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses...
November 30, 2016: Chemical & Pharmaceutical Bulletin
keyword
keyword
114511
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"