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https://www.readbyqxmd.com/read/27784742/allogeneic-stem-cell-transplantation-a-historical-and-scientific-overview
#1
REVIEW
Anurag K Singh, Joseph P McGuirk
The field of hematopoietic stem cell transplant (HSCT) has made ground-breaking progress in the treatment of many malignant and nonmalignant conditions. It has also pioneered the concepts of stem cell therapy and immunotherapy as a tool against cancer. The success of transplant for hematologic malignancies derives both from the ability to treat patients with intensive chemoradiotherapy and from potent graft-versus-leukemia (GVL) effects mediated by donor immunity. Additionally, HSCT has been a curative therapy for several nonmalignant hematologic disorders through the provision of donor-derived hematopoiesis and immunity...
October 26, 2016: Cancer Research
https://www.readbyqxmd.com/read/27715384/allogeneic-hematopoietic-stem-cell-transplantation-for-nonmalignant-hematologic-disorders-using-chemotherapy-only-cytoreductive-regimens-and-t-cell-depleted-grafts-from-human-leukocyte-antigen-matched-or-mismatched-donors
#2
Alberto Mussetti, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Rachel Lehrman, Julianne M Ruggiero, Kevin Curran, Rachel Kobos, Richard O'Reilly, Farid Boulad
Nonmalignant hematologic disorders (NMHD) of childhood comprise a variety of disorders, including acquired severe aplastic anemia and inherited marrow failure syndromes. Patients with high-risk NMHD without matched related donors fare poorly with allogeneic hematopoietic alternative donor stem cell transplantation (allo-HSCT) and are at high risk for developing graft-versus-host disease following unmodified grafts. The authors retrospectively analyzed data on 18 patients affected by NMHD, lacking a human leukocyte antigen (HLA)-identical sibling donor, who underwent an alternative donor allo-HSCT at their institution between April 2005 and May 2013...
October 7, 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27544796/nf-%C3%AE%C2%BAb-dysregulation-in-multiple-myeloma
#3
Geoffrey M Matthews, Ricardo de Matos Simoes, Eugen Dhimolea, Michal Sheffer, Sara Gandolfi, Olga Dashevsky, Jeffrey D Sorrell, Constantine S Mitsiades
The nuclear factor-κB (NF-κB) transcription factor family plays critical roles in the pathophysiology of hematologic neoplasias, including multiple myeloma. The current review examines the roles that this transcription factor system plays in multiple myeloma cells and the nonmalignant accessory cells of the local microenvironment; as well as the evidence indicating that a large proportion of myeloma patients harbor genomic lesions which perturb diverse genes regulating the activity of NF-κB. This article also discusses the therapeutic targeting of the NF-κB pathway using proteasome inhibitors, a pharmacological class that has become a cornerstone in the therapeutic management of myeloma; and reviews some of the future challenges and opportunities for NF-κB-related research in myeloma...
August 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27518929/new-apheresis-indications-in-hematological-disorders
#4
Huy P Pham, Joseph Schwartz
PURPOSE OF REVIEW: Therapeutic apheresis can be used to treat many diseases. The American Society for Apheresis (ASFA) publishes Guidelines on the use of therapeutic apheresis every 3 years with the goal of providing the best available evidence for apheresis practice as well as clinical expertise. The 2016 (7th ed.) ASFA Guidelines contain 87 diseases (up from 78 in the 6th ed.) and 179 indications. This review outlines three new therapeutic apheresis indications for hematological disorders...
November 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27313619/haploidentical-stem-cell-transplantation-in-adult-haematological-malignancies
#5
REVIEW
Kevon Parmesar, Kavita Raj
Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27190320/hepatitis-b-virus-reactivation-in-the-setting-of-cancer-chemotherapy-and-other-immunosuppressive-drug-therapy
#6
Stevan A Gonzalez, Robert P Perrillo
Hepatitis B virus reactivation (HBVr) is an important complication of immunosuppressive drug therapy (ISDT). It can occur with active or resolved hepatitis B virus (HBV) infection with a clinical spectrum that ranges from mild elevations in liver tests to fulminant hepatic failure. The risk of it occurring is determined by the interplay between HBV serological status, level of viremia, and the immunosuppressive potency of the drug(s) used. Reactivation is most common during treatment of hematologic malignancies but also occurs with chemotherapy for breast cancer and numerous other solid organ malignancies, organ transplant, and immune suppression for nonmalignant conditions...
June 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27135977/role-of-the-carma1-bcl10-malt1-complex-in-lymphoid-malignancies
#7
Mélanie Juilland, Margot Thome
PURPOSE OF REVIEW: The CARMA1/BCL10/MALT1 (CBM) complex is a multimeric signaling complex controlling several important aspects of lymphocyte activation. Gain-of-function mutations in the genes encoding CBM proteins or their upstream regulators are associated with lymphoid malignancies, whereas loss-of-function mutations lead to immunodeficiency. This review reports on recent findings advancing our understanding of how CBM proteins contribute to malignant and nonmalignant hematological diseases in humans...
July 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27129167/potential-role-of-exosome-associated-microrna-panels-and-in-vivo-environment-to-predict-drug-resistance-for-patients-with-multiple-myeloma
#8
Li Zhang, Ling Pan, Bing Xiang, Huanling Zhu, Yu Wu, Meng Chen, Pujun Guan, Xingli Zou, C Alexander Valencia, Biao Dong, Jianjun Li, Liping Xie, Hongbing Ma, Fangfang Wang, Tian Dong, Xiao Shuai, Ting Niu, Ting Liu
Multiple myeloma (MM) is the second most common hematologic neoplasms and an appropriate in vivo environment for myeloma cells has potential implications for initiation, progression, and metastasis of MM. Exosomes, entities carrying microRNAs (miRNAs) to target locations, participate in the cross-talk between myeloma cells and nonmalignant components of the in vivo environment. This study disclosed the emerging roles of circulating exosome-associated miRNAs in drug resistance (DR) of MM. To this end, the medical records of consecutively hospitalized MM patients, who received novel agents-based therapies, were analyzed...
May 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27110922/novel-approaches-for-preventing-acute-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
Sophie Servais, Yves Beguin, Loic Delens, Grégory Ehx, Gilles Fransolet, Muriel Hannon, Evelyne Willems, Stéphanie Humblet-Baron, Ludovic Belle, Frédéric Baron
INTRODUCTION: Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers potential curative treatment for a wide range of malignant and nonmalignant hematological disorders. However, its success may be limited by post-transplant acute graft-versus-host disease (aGVHD), a systemic syndrome in which donor's immune cells attack healthy tissues in the immunocompromised host. aGVHD is one of the main causes of morbidity and mortality after alloHSCT. Despite standard GVHD prophylaxis regimens, aGVHD still develops in approximately 40-60% of alloHSCT recipients...
August 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27058693/the-effect-of-icd-10-cm-coding-on-nonmalignant-hematology
#10
Andrew D Boyd
No abstract text is available yet for this article.
November 2015: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/26906327/time-related-variations-in-stem-cell-harvesting-of-umbilical-cord-blood
#11
Gianluigi Mazzoccoli, Giuseppe Miscio, Andrea Fontana, Massimiliano Copetti, Massimo Francavilla, Alberto Bosi, Federico Perfetto, Alice Valoriani, Angelo De Cata, Michele Santodirocco, Angela Totaro, Rosa Rubino, Lazzaro di Mauro, Roberto Tarquini
Umbilical cord blood (UCB) contains hematopoietic stem cells and multipotent mesenchymal cells useful for treatment in malignant/nonmalignant hematologic-immunologic diseases and regenerative medicine. Transplantation outcome is correlated with cord blood volume (CBV), number of total nucleated cells (TNC), CD34+ progenitor cells and colony forming units in UCB donations. Several studies have addressed the role of maternal/neonatal factors associated with the hematopoietic reconstruction potential of UCB, including: gestational age, maternal parity, newborn sex and birth weight, placental weight, labor duration and mode of delivery...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26888257/galectin-1-drives-lymphoma-cd20-immunotherapy-resistance-validation-of-a-preclinical-system-to-identify-resistance-mechanisms
#12
Jacquelyn M Lykken, Mayuka Horikawa, Veronique Minard-Colin, Masahiro Kamata, Tomomitsu Miyagaki, Jonathan C Poe, Thomas F Tedder
Non-Hodgkin lymphoma (NHL) is the most commonly diagnosed hematologic cancer of adults in the United States, with the vast majority of NHLs deriving from malignant B lymphocytes that express cell surface CD20. CD20 immunotherapy (rituximab) is widely used to treat NHL, even though the initial effectiveness of rituximab varies widely among patients and typically wanes over time. The mechanisms through which lymphomas initially resist or gain resistance to immunotherapy are not well established. To address this, a preclinical mouse model system was developed to comprehensively identify lymphoma transcriptomic changes that confer resistance to CD20 immunotherapy...
April 14, 2016: Blood
https://www.readbyqxmd.com/read/26865995/hdac-and-hdac-inhibitor-from-cancer-to-cardiovascular-diseases
#13
REVIEW
Somy Yoon, Gwang Hyeon Eom
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in several pathophysiologic states. HDAC inhibitors have been highlighted as a novel category of anti-cancer drugs. To date, four HDAC inhibitors, Vorinostat, Romidepsin, Panobinostat, and Belinostat, have been approved by the United States Food and Drug Administration...
January 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/26862289/laparoscopic-splenectomy-in-children-with-benign-hematological-diseases-leaving-nothing-behind-policy
#14
Mohammad Gharieb Khirallah, Nagi Ebrahim Eldessoky, Akram Mohamed Elbatarny, Mohamed Ebrahim Elsawaf
CONTEXT: Laparoscopic splenectomy (LS) is considered the standard approach for the treatment of children with nonmalignant hematological diseases due to the advances in the minimal invasive surgery over the conventional splenectomy (CS). Different techniques are involved in the operation to secure the hilum. AIM: The use of (Ligasure™) is a safe, effective, less time consuming and with less complications rate. MATERIALS AND METHODS: Sixty children (33 with thalassemia, 20 with immune thrombocytopenic purpura [ITP] and seven with spherocytosis) were operated during the period from June 2007 to December 2014...
January 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/26860634/alternative-donor-hematopoietic-stem-cell-transplantation-with-post-transplantation-cyclophosphamide-for-nonmalignant-disorders
#15
Orly R Klein, Allen R Chen, Christopher Gamper, David Loeb, Elias Zambidis, Nicolas Llosa, Jeffrey Huo, Amy E Dezern, Diana Steppan, Nancy Robey, Mary Jo Holuba, Kenneth R Cooke, Heather J Symons
Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for many nonmalignant pediatric disorders, including hemoglobinopathies, bone marrow failure syndromes, and immunodeficiencies. There is great success using HLA-matched related donors for these patients; however, the use of alternative donors has been associated with increased graft failure, graft-versus-host disease (GVHD), and transplant-related mortality (TRM). HSCT using alternative donors with post-transplantation cyclophosphamide (PT/Cy) for GVHD prophylaxis has been performed for hematologic malignancies with engraftment, GVHD, and TRM comparable with that seen with HLA-matched related donors...
May 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26802323/late-effects-surveillance-recommendations-among-survivors-of-childhood-hematopoietic-cell-transplantation-a-children-s-oncology-group-report
#16
REVIEW
Eric J Chow, Lynnette Anderson, K Scott Baker, Smita Bhatia, Gregory M T Guilcher, Jennifer T Huang, Wendy Pelletier, Joanna L Perkins, Linda S Rivard, Tal Schechter, Ami J Shah, Karla D Wilson, Kenneth Wong, Satkiran S Grewal, Saro H Armenian, Lillian R Meacham, Daniel A Mulrooney, Sharon M Castellino
Hematopoietic cell transplantation (HCT) is an important curative treatment for children with high-risk hematologic malignancies, solid tumors, and, increasingly, nonmalignant diseases. Given improvements in care, there are a growing number of long-term survivors of pediatric HCT. Compared with childhood cancer survivors who did not undergo transplantation, HCT survivors have a substantially increased burden of serious chronic conditions and impairments involving virtually every organ system and overall quality of life...
May 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26760415/evaluation-of-patients-with-leukocytosis
#17
Lyrad K Riley, Jedda Rupert
An elevated white blood cell count has many potential etiologies, including malignant and nonmalignant causes. It is important to use age- and pregnancy-specific normal ranges for the white blood cell count. A repeat complete blood count with peripheral smear may provide helpful information, such as types and maturity of white blood cells, uniformity of white blood cells, and toxic granulations. The leukocyte differential may show eosinophilia in parasitic or allergic conditions, or it may reveal lymphocytosis in childhood viral illnesses...
December 1, 2015: American Family Physician
https://www.readbyqxmd.com/read/26684920/clotrimazole-troches-induce-supratherapeutic-blood-levels-of-sirolimus-and-tacrolimus-in-an-allogeneic-hematopoietic-cell-transplant-recipient-resulting-in-acute-kidney-injury
#18
Jessica El-Asmar, Rebecca Gonzalez, Ryan Bookout, Asmita Mishra, Mohamed A Kharfan-Dabaja
Allogeneic hematopoietic cell transplantation is a potential curative treatment option for various malignant and nonmalignant hematologic disorders. Patients undergoing an allogeneic hematopoietic cell transplant are prescribed immune-suppressant therapies to facilitate hematopoietic donor-cell engraftment and prevent graft-versus-host disease. Drug-drug interactions may occur, owing to exposure to complex multidrug regimens with narrow therapeutic windows and high toxicity profiles. Here, we describe a unique case of a 65-year-old man with poor-risk acute myeloid leukemia who underwent a matched-sibling hematopoietic cell allograft...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/26667746/high-body-mass-index-among-patients-undergoing-hematopoietic-stem-cell-transplantation-results-of-a-cross-sectional-evaluation-of-nutritional-status-in-a-private-hospital
#19
Andrea Z Pereira, Elivane S Victor, Paulo Vidal Campregher, Silvia M F Piovacari, Juliana S Bernardo Barban, Wilson L Pedreira, Nelson Hamerschlak
BACKGROUND: nutritional status before hematopoietic stem cell transplantation (HSCT) affects prognosis: better nourished patients have shorter time to engraftment, while malnutrition is associated with increase of mortality rates, complications, medical costs, poor quality of life and hospitalization stay. Furthermore, underweight patients have increased risk of death in the early post- HSCT period, and non-relapse mortality is greater for those who are extremely underweight, overweight and obese...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26543526/bacterial-infections-following-splenectomy-for-malignant-and-nonmalignant-hematologic-diseases
#20
REVIEW
Giuseppe Leone, Eligio Pizzigallo
Splenectomy, while often necessary in otherwise healthy patients after major trauma, finds its primary indication for patients with underlying malignant or nonmalignant hematologic diseases. Indications of splenectomy for hematologic diseases have been reducing in the last few years, due to improved diagnostic and therapeutic tools. In high-income countries, there is a clear decrease over calendar time in the incidence of all indication splenectomy except nonmalignant hematologic diseases. However, splenectomy, even if with different modalities including laparoscopic splenectomy and partial splenectomy, continue to be a current surgical practice both in nonmalignant hematologic diseases, such as Immune Thrombocytopenic Purpura (ITP), Autoimmune Hemolytic Anemia (AIHA), Congenital Hemolytic Anemia such as Spherocytosis, Sickle Cell Anemia and Thalassemia and Malignant Hematological Disease, such as lymphoma...
2015: Mediterranean Journal of Hematology and Infectious Diseases
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