Rebecca Herzog, Juan Manuel Sacnun, Guadalupe González-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucía Pascual-Antón, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel López-Cabrera, Seth L Alper, Christoph Aufricht, Klaus Kratochwill
Life-saving renal replacement therapy by peritoneal dialysis (PD) is limited in use and duration by progressive impairment of peritoneal membrane integrity and homeostasis. Preservation of peritoneal membrane integrity during chronic PD remains an urgent but long unmet medical need. PD therapy failure results from peritoneal fibrosis and angiogenesis caused by hypertonic PD fluid (PDF)-induced mesothelial cytotoxicity. However, the pathophysiological mechanisms involved are incompletely understood, limiting identification of therapeutic targets...
August 25, 2021: Science Translational Medicine