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https://www.readbyqxmd.com/read/28251021/prevention-of-intraabdominal-adhesions-an-experimental-study-using-mitomycin-c-and-4-icodextrin
#1
Murat Urkan, İsmail Hakkı Özerhan, Aytekin Ünlü, Mehmet Fatih Can, Erkan Öztürk, Armağan Günal, Gökhan Yağcı
BACKGROUND: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations. AIMS: We compared the anti-adhesive effects of two different agents on postoperative adhesion formation in a cecal abrasion model. STUDY DESIGN: Experimental animal study. METHODS: Forty Wistar albino type female rats were anesthetized and underwent laparotomy...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28153193/low-gdp-solution-and-glucose-sparing-strategies-for-peritoneal-dialysis
#2
REVIEW
Cheuk Chun Szeto, David W Johnson
Long-term exposure to a high glucose concentration in conventional peritoneal dialysis (PD) solution has a number of direct and indirect (via glucose degradation products [GDP]) detrimental effects on the peritoneal membrane, as well as systemic metabolism. Glucose- or GDP-sparing strategies often are hypothesized to confer clinical benefits to PD patients. Icodextrin (glucose polymer) solution improves peritoneal ultrafiltration and reduces the risk of fluid overload, but these beneficial effects are probably the result of better fluid removal rather than being glucose sparing...
January 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28096442/kinetic-modeling-of-incremental-ambulatory-peritoneal-dialysis-exchanges
#3
Steven Guest, John K Leypoldt, Michelle E Cassin, Martin J Schreiber
♦ Background: Incremental peritoneal dialysis (PD), the gradual introduction of dialysate exchanges at less than full-dose therapy, has been infrequently described in clinical reports. One concern with less than full-dose dialysis is whether urea clearance targets are achievable with an incremental regimen. In this report, we used a large database of PD patients, across all membrane transport types, and performed urea kinetic modeling determinations of possible incremental regimens for an individual membrane type...
January 17, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28089175/reduction-of-carcinomatosis-risk-using-icodextrin-as-a-carrier-solution-of-intraperitoneal-oxaliplatin-chemotherapy
#4
I Jouvin, H Najah, C Pimpie, C Canet Jourdan, R Kaci, M Mirshahi, C Eveno, M Pocard
There is no standard treatment in patients with high risk metachronous peritoneal carcinomatosis (PC) in colonic cancer, as perforated tumour or synchronous ovarian metastasis. Icodextrin 4% (ICDX), presently used to prevent postoperative abdominal adhesions, could inhibit the coactivation of the tumour cells and the microenvironment cells, associated with the development of PC. The aim of this study was to inhibit the formation of the PC in a murine model mimicking surgical situation using ICDX and intraperitoneal (IP) prophylactic chemotherapy...
January 9, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28077410/health-policies-on-dialysis-modality-selection-a-nationwide-population-cohort-study
#5
Yi-Chun Lin, Yen-Chung Lin, Chih-Chin Kao, Hsi-Hsien Chen, Chih-Cheng Hsu, Mai-Szu Wu
OBJECTIVES: In Taiwan, peritoneal dialysis (PD) and haemodialysis are fully accessible to patients with end-stage renal disease. However, the usage of PD is considered low in Taiwan. Since 2005, 4 major policies have been implemented by Taiwan's Ministry of Health and Welfare, namely a multidisciplinary predialysis care programme and usage increasing the PD incidence as a key performance indicator (KPI) for hospital accreditation, both of which were implemented in 2006; reimbursement of the glucose-free dialysate, icodextrin that was implemented in 2007; and insurance reimbursement for renting automated PD machines that was implemented in 2008...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28066919/innovations-in-treatment-delivery-risk-of-peritonitis-and-patient-retention-on-peritoneal-dialysis
#6
Beth Piraino
Early innovations in the delivery of peritoneal dialysis (PD) markedly improved its acceptability and lowered peritonitis rates. The standard osmotic agent was, and continues to be dextrose, an agent that is not ideal as it is readily absorbed. The development of icodextrin-containing dialysis fluid has allowed a long dwell time to provide more effective ultrafiltration. The development of a smaller, more easily used automated cycler, led to an increase in the proportion of patients on the cycler as opposed to CAPD...
January 8, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/27800586/liquid-antiadhesive-agents-for-intraperitoneal-hernia-repair-procedures-artiss-%C3%A2-compared-to-coseal-%C3%A2-and-adept-%C3%A2-in-an-ipom-rat-model
#7
Simone Gruber-Blum, R H Fortelny, C Keibl, J Brand, M Lechner, H Redl, A H Petter-Puchner
BACKGROUND: Adhesion formation remains an important issue in hernia surgery. Liquid agents were developed for easy and versatile application, especially in laparoscopy. The aim of this study was to compare the antiadhesive effect of fibrin sealant (FS, Artiss(®)), Icodextrin (ID, Adept(®)) and Polyethylene glycol (PEG, CoSeal(®)) alone and in combination and to evaluate the resulting effect on tissue integration of the mesh. METHODS: A total of 56 Sprague-Dawley rats were operated in open IPOM technique...
October 31, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27722783/is-there-such-a-thing-as-biocompatible-peritoneal-dialysis-fluid
#8
REVIEW
Claus Peter Schmitt, Christoph Aufricht
Introduction of the so-called biocompatible peritoneal dialysis (PD) fluids was based on a large body of experimental evidence and various clinical trials suggesting important clinical benefits. Of these, until now, only preservation of residual renal function-likely due to lower glucose degradation product load and, in case of icodextrin, improved fluid and blood pressure control-have consistently been proven, whereas the impact on important clinical endpoints such as infectious complications, preservation of PD membrane transport function, and patient outcome, are still debated...
October 8, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27616762/icodextrin-induced-acute-pancreatitis-in-a-peritoneal-dialysis-patient-a-case-report-and-literature-review%C3%A2
#9
REVIEW
Sofia Rubinstein, Rafael Franjul, Sikander Surana, Joshua Fogel
The 7.5% icodextrin solution is widely used for long-dwell in peritoneal dialysis (PD) regimens as an alternative osmotic agent to glucose. It has been defined as a biocompatible agent because of its iso-osmolarity and is generally safe and well tolerated. Icodextrin and its hydrolyzed metabolites are found in systemic circulation. In serum, icodextrin interferes with amylase determination causing a significantly decreased plasma amylase level making it unreliable for the diagnosis of acute pancreatitis. Lipase measurement provides an alternative and accurate method for diagnosing acute pancreatitis (AP) in patients using icodextrin...
November 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27593771/effects-of-4-icodextrin-on-experimental-spinal-epidural-fibrosis
#10
Turker Karanci, Bilal Kelten, Alper Karaoglan, Nilgun Cinar, Ahmet Midi, Veysel Antar, Hidayet Akdemir, Zeynep Kara
AIM: The aim of this experimental study was to investigate whether spinal epidural 4% glucose polymer solution is effective in the prevention of postoperative fibrosis. MATERIAL AND METHODS: Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received 4% icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically...
2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27530675/newly-developed-neutralized-ph-icodextrin-dialysis-fluid-nonclinical-evaluation
#11
Naoya Yamaguchi, Keiichi Miyamoto, Tomohiro Murata, Eiji Ishikawa, Takashi Horiuchi
A two-compartment system (NICOPELIQ; NICO, Terumo Co., Tokyo, Japan) has recently been developed to neutralize icodextrin peritoneal dialysis fluid (PDF). In this study, a nonclinical evaluation of NICO was carried out to evaluate biocompatibility as well as water transport ability. Glucose degradation products (GDPs) in the icodextrin PDFs were analyzed via high-performance liquid chromatography (HPLC). The cell viability of human peritoneal mesothelial cells derived from peritoneal dialysis effluent (PDE-HPMCs) was evaluated as well as the amount of lactate dehydrogenase (LDH) released after exposure to different PDFs (NICO and EXTRANEAL [EX, Baxter Healthcare Corp...
August 2016: Artificial Organs
https://www.readbyqxmd.com/read/27336367/deciphering-the-contribution-of-biofilm-to-the-pathogenesis-of-peritoneal-dialysis-infections-characterization-and-microbial-behaviour-on-dialysis-fluids
#12
Joana Sampaio, Diana Machado, Ana Marta Gomes, Idalina Machado, Cledir Santos, Nelson Lima, Maria João Carvalho, António Cabrita, Anabela Rodrigues, Margarida Martins
Infections are major complications in peritoneal dialysis (PD) with a multifactorial etiology that comprises patient, microbial and dialytic factors. This study aimed at investigating the contribution of microbial biofilms on PD catheters to recalcitrant infections and their interplay with PD related-factors. A prospective observational study was performed on 47 patients attending Centro Hospitalar of Porto and Vila Nova de Gaia/Espinho to whom the catheter was removed due to infectious (n = 16) and non-infectious causes (n = 31)...
2016: PloS One
https://www.readbyqxmd.com/read/27282852/the-trio-trial-a-randomized-controlled-clinical-trial-evaluating-the-effect-of-a-biocompatible-peritoneal-dialysis-solution-on-residual-renal-function
#13
Tabo Sikaneta, George Wu, Mohamed Abdolell, Anita Ng, Sara Mahdavi, Anton Svendrovski, Tony Tu, Trish Mercer, Matthew Tong, Dimitrios Oreopoulos, Paul Tam
UNLABELLED:BACKGROUND AND OBJECTIVE: Residual renal function (RRF) correlates with mortality and morbidity rates in patients receiving peritoneal dialysis (PD). We examined the effect of a biocompatible PD solution (Gambrosol Trio; Gambro Lundia AB, Lund, Sweden) with lower concentrations of glucose degradation products on rates of decline in RRF. ♦ DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Incident patients at 2 centers in Canada and 1 in Hong Kong were randomized (by minimization) in an open-label parallel group trial to receive Gambrosol Trio or standard PD solution (Dianeal; Baxter Healthcare, Mississauga, Canada) for 2 years...
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27178072/impact-of-fill-volume-on-ultrafiltration-with-icodextrin-in-children-on-chronic-peritoneal-dialysis
#14
Sharon Rousso, Tonny M Banh, Susan Ackerman, Elizabeth Piva, Christoph Licht, Elizabeth A Harvey
BACKGROUND: Icodextrin is a solution of glucose polymers developed to provide sustained ultrafiltration over an extended dwell. Our aim was to determine whether or not fill volume with icodextrin contributes to the ability to achieve ultrafiltration in children. METHODS: The charts of all children on chronic peritoneal dialysis between January 2000 and July 2014 were screened for the use of an icodextrin day dwell. Data were extracted from the electronic chart and the HomeChoice™ Pro card and corrected for body surface area (BSA)...
October 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27147292/stability-and-compatibility-of-antibiotics-in-peritoneal-dialysis-solutions-applied-to-automated-peritoneal-dialysis-in-the-pediatric-population
#15
Guillaume Deslandes, Matthieu Grégoire, Régis Bouquié, Aude Le Marec, Sophie Allard, Eric Dailly, Alain Pineau, Emma Allain-Launay, Pascale Jolliet, Gwenaëlle Roussey, Dominique Navas
♦ OBJECTIVES: Assess the stability of several antibiotics in peritoneal dialysis (PD) solutions under common conditions of use in pediatrics, particularly in automated PD. ♦ METHODS: Amoxicillin, cefazolin, cefepime, ceftazidime, imipenem, cotrimoxazole, tobramycin, vancomycin, and the association of ceftazidime + vancomycin and ceftazidime + tobramycin, were tested in 3 different PD solutions: bicarbonate/lactate solution with 2 glucose concentrations (Physioneal 1.36 and 3.86%; Baxter Healthcare Corporation, Deerfield, IL, USA) and an icodextrin-containing solution (Extraneal; Baxter Healthcare Corporation, Deerfield, IL, USA)...
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27115159/analysis-of-technique-and-patient-survival-over-time-in-patients-undergoing-peritoneal-dialysis
#16
I-Kuan Wang, Chi-Yu Lu, Chih-Hsin Muo, Chiz-Tzung Chang, Tzung-Hai Yen, Chiu-Ching Huang, Tsai-Chung Li, Fung-Chang Sung
PURPOSE: This study used national claims data to investigate the technique and patient survival over time in incident peritoneal dialysis (PD) patients. METHODS: Incident end-stage renal disease patients undergoing PD and older than 18 years were selected from Taiwan health insurance databases. These patients were grouped into three study periods according to year of dialysis initiation: 1997-2001, 2002-2006, and 2007-2011. The study end-points included technique failure and mortality...
July 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27043667/effect-of-icodextrin-solution-on-the-preservation-of-residual-renal-function-in-peritoneal-dialysis-patients-a-randomized-controlled-study
#17
RANDOMIZED CONTROLLED TRIAL
Tae Ik Chang, Dong-Ryeol Ryu, Tae-Hyun Yoo, Hyung Jong Kim, Ea Wha Kang, Hyunwook Kim, Jae Hyun Chang, Dong Ki Kim, Sung Jin Moon, Soo Young Yoon, Seung Hyeok Han
Although icodextrin solution has been highlighted in the fluid management compared to glucose-based solutions, proof of a beneficial effect of icodextrin solution on residual renal function (RRF) is lacking. We conducted a multicenter prospective randomized controlled open-label trial to investigate whether icodextrin solution can preserve RRF.One hundred patients with urine volume ≥750 mL/day from 8 centers in Korea were randomly assigned to receive 1 exchange of icodextrin solution for a ≥8 hour-dwell time and 2 exchanges of 1...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26959245/comparison-of-peritoneal-low-molecular-weight-protein-removal-in-ccpd-and-capd-patients-based-on-c-terminal-agrin-fragment-clearance
#18
Dominik Steubl, Marcel Roos, Stefan Hettwer, Susanne Angermann, Ming Wen, Christoph Schmaderer, Peter Luppa, Uwe Heemann, Lutz Renders
BACKGROUND/AIMS: This study compares the peritoneal elimination of the low-molecular-weight-protein (LMWP) C-terminal agrin fragment (tCAF, size 22 kDa), a promising biomarker for kidney function, in continuous cycling peritoneal dialysis (CCPD) and continuous ambulatory peritoneal dialysis (CAPD). METHODS: 103 sets of serum, 24h-urine and dialysate samples were obtained in 15 CCPD (63 sets) and 11 CAPD (40 sets) patients. Total, renal and peritoneal substrate removals/clearances were measured/calculated for tCAF, creatinine, blood-urea-nitrogen (BUN), cystatin C and albumin and correlated with the peritoneal transport type...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/26934850/role-of-icodextrin-in-the-prevention-of-small-bowel-obstruction-safety-randomized-patients-control-of-the-first-300-in-the-adept-trial
#19
RANDOMIZED CONTROLLED TRIAL
T Sakari, R Sjödahl, L Påhlman, U Karlbom
AIM: Adhesions are the most common cause of small bowel obstruction (SBO). The costs of hospitalization and surgery for SBO are substantial for the health-care system. The adhesion-limiting potential of icodextrin has been shown in patients undergoing surgery for gynaecological diseases. A randomized, multicentre trial in colorectal cancer surgery started in 2009 with the aim of evaluating whether icodextrin could reduce the long-term risk of surgery for SBO. Because of some concerns about complications (especially anastomotic leakage) after icodextrin use, a preplanned interim analysis of morbidity and mortality was conducted...
March 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/26929256/effects-of-icodextrin-and-glucose-bicarbonate-lactate-buffered-peritoneal-dialysis-fluids-on-effluent-cell-population-and-biocompatibility-markers-il-6-and-ca125-in-incident-peritoneal-dialysis-patients
#20
Sylvie Opatrná, Anna Pöpperlová, Daniel Lysák, Radka Fuchsová, Ladislav Trefil, Jaroslav Racek, Ondrej Topolčan
Icodextrin peritoneal dialysis (PD) solution has been shown to increase interleukin-6 (IL-6) levels in PD effluent as well as leukocyte and mesothelial cell count. Mesothelial cells release cancer antigen 125 (CA125), which is used as a marker of mesothelial cell mass. This 1-year prospective study was designed to compare peritoneal effluent cell population, its inflammatory phenotype and biocompatibility biomarkers IL-6 and CA125 between icodextrin (E) and glucose bicarbonate/lactate (P) based PD solutions...
April 2016: Therapeutic Apheresis and Dialysis
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