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Inflammatory biomarkers

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https://www.readbyqxmd.com/read/28749594/seizure-activity-per-se-does-not-induce-tissue-damage-markers-in-human-neocortical-focal-epilepsy
#1
Laura Rossini, Rita Garbelli, Vadym Gnatkovsky, Giuseppe Didato, Flavio Villani, Roberto Spreafico, Francesco Deleo, Giorgio Lo Russo, Giovanni Tringali, Francesca Gozzo, Laura Tassi, Marco de Curtis
Objective The contribute of recurring seizures to the progression of epileptogenesis is debated. Seizure-induced brain damage is not conclusively demonstrated both in humans and in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on post-surgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant focal epilepsy. Methods The expression patterns of specific glial, neuronal and inflammatory molecules was evaluated by immunohistochemistry in the core of type II focal cortical dysplasias (FCD-II), at the FCD boundary (perilesion) and in the adjacent normal-appearing area included in the epileptogenic region...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749394/serum-levels-of-soluble-urokinase-plasminogen-activator-receptor-as-a-new-inflammatory-marker-in-adolescent-obesity
#2
Ummugulsum Can, Muammer Buyukinan, Fatma Humeyra Yerlikaya
BACKGROUND & OBJECTIVES: Obesity is known for low-grade inflammatory state with enhanced production of inflammatory mediators in children and adolescents. Soluble urokinase plasminogen activator receptor (suPAR) can be generated as a pro-inflammatory marker. This study was conducted to evaluate the role of suPAR, and its association with leptin, adiponectin, interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP) and fibrinogen in adolescent obesity. METHODS: A total of 98 participants, 55 obese individuals and 43 healthy controls, aged between 10 and 17 yr, were included in the study...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28748764/inflammatory-biomarkers-in-atrial-fibrillation
#3
Effimia Zacharia, Nikolaos Papageorgiou, Adam Ioannou, Gerasimos Siasos, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência, Dimitris Tousoulis
During the last few years, a significant number of studies have attempted to clarify the underlying mechanisms that lead to the presentation of atrial fibrillation (AF). Inflammation is a key component of the pathophysiological processes that lead to the development of AF; the amplification of inflammatory pathways triggers AF, and, in tandem, AF increases the inflammatory state. Indeed, the plasma levels of several inflammatory biomarkers are elevated in patients with AF. In addition, the levels of specific inflammatory biomarkers may provide information regarding to the AF duration...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748366/clinical-features-of-psoriatic-arthritis-a-comprehensive-review-of-unmet-clinical-needs
#4
REVIEW
Angela McArdle, Stephen Pennington, Oliver FitzGerald
Psoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis-especially rheumatoid arthritis (RA)...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28747965/systemic-white-blood-cell-count-as-a-biomarker-associated-with-severity-of-chronic-obstructive-lung-disease
#5
Hyeon-Kyoung Koo, Hyung Koo Kang, Pamela Song, Hye Kyeong Park, Sung-Soon Lee, Hoon Jung
BACKGROUND: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. METHODS: The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28746378/high-molecular-weight-adiponectin-homa-ir-ratio-as-a-biomarker-of-metabolic-syndrome-in-urban-multiethnic-brazilian-subjects
#6
Virgínia Genelhu de Abreu, Cyro José de Moraes Martins, Patricia Aguiar Cardoso de Oliveira, Emilio Antonio Francischetti
Metabolic syndrome (MetS) has an important epidemiological relevance due to its increasing prevalence and association with type 2 diabetes and cardiovascular disease. Insulin resistance is a core feature of the MetS. HOMA-IR is a robust clinical and epidemiological marker of MetS. Adiponectin is an adipokine with insulin-sensitizing and anti-inflammatory functions; its levels decrease as number of components of MetS increases. High-molecular weight adiponectin (HMWA) is the multimer responsible for the relationship of adiponectin with insulin sensitivity...
2017: PloS One
https://www.readbyqxmd.com/read/28743667/integrative-analysis-of-mrna-and-mirna-expression-profiles-in-oral-lichen-planus-preliminary-results
#7
Junjun Chen, Guanhuan Du, Yufeng Wang, Linjun Shi, Jun Mi, Guoyao Tang
OBJECTIVE: Oral lichen planus (OLP), a chronic inflammatory disease of unknown etiology, is considered a potentially malignant oral disorder. The aim of the present study was to analyze candidate microRNAs (miRNAs) and genes from patients with OLP and healthy controls (HCs). STUDY DESIGN: Biopsy specimens of the oral mucosa were collected from patients with OLP (n = 9) and from HCs (n = 4). Differentially expressed miRNAs and differentially expressed genes were screened by using next-generation sequencing with DESeq and edgeR software algorithms...
June 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28743666/biological-significance-of-5-hydroxymethylcytosine-in-oral-epithelial-dysplasia-and-oral-squamous-cell-carcinoma
#8
Maria Carolina Cuevas-Nunez, Camilla Borges F Gomes, Sook-Bin Woo, Matthew R Ramsey, Xiaoxin L Chen, Shuyun Xu, Ting Xu, Qian Zhan, George F Murphy, Christine G Lian
OBJECTIVES: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC. STUDY DESIGN: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC...
June 16, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28742106/epidemiology-of-enteroaggregative-escherichia-coli-infections-and-associated-outcomes-in-the-mal-ed-birth-cohort
#9
Elizabeth T Rogawski, Richard L Guerrant, Alexandre Havt, Ila F N Lima, Pedro H Q S Medeiros, Jessica C Seidman, Benjamin J J McCormick, Sudhir Babji, Dinesh Hariraju, Ladaporn Bodhidatta, Jasmin Shrestha, Japhat Anania, Athanasia Maro, Amidou Samie, Pablo Peñataro Yori, Shahida Qureshi, Mustafa Mahfuz, Pascal O Bessong, Margaret N Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Dennis R Lang, Michael Gottlieb, Eric R Houpt, Aldo A M Lima
BACKGROUND: Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their associations with environmental enteropathy biomarkers and growth outcomes over the first two years of life in eight low-resource settings of the MAL-ED study. METHODS: EAEC infections were detected by PCR gene probes for aatA and aaiC virulence traits in 27,094 non-diarrheal surveillance stools and 7,692 diarrheal stools from 2,092 children in the MAL-ED birth cohort...
July 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28741603/role-of-the-lung-microbiome-in-the-pathogenesis-of-chronic-obstructive-pulmonary-disease
#10
REVIEW
Lei Wang, Ke Hao, Ting Yang, Chen Wang
OBJECTIVE: The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis...
July 24, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28740457/perioperative-increase-in-neutrophil-cd64-expression-is-an-indicator-for-intra-abdominal-infection-after-colorectal-cancer-surgery
#11
Milena Kerin Povsic, Bojana Beovic, Alojz Ihan
BACKGROUND: Colorectal surgery is associated with a high incidence of postoperative infections. Early clinical signs are difficult to distinguish from the systemic inflammatory response related to surgical trauma. Timely diagnosis may significantly improve the outcome. The objective of this study was to compare a new biomarker index CD64 for neutrophils (iCD64n) with standard biomarkers, white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and procalcitonin (PCT) for the early detection of postoperative infection...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740377/mathematical-modeling-of-postcoinfection-with-influenza-a-virus-and-streptococcus-pneumoniae-with-implications-for-pneumonia-and-copd-risk-assessment
#12
Yi-Hsien Cheng, Shu-Han You, Yi-Jun Lin, Szu-Chieh Chen, Wei-Yu Chen, Wei-Chun Chou, Nan-Hung Hsieh, Chung-Min Liao
BACKGROUND: The interaction between influenza and pneumococcus is important for understanding how coinfection may exacerbate pneumonia. Secondary pneumococcal pneumonia associated with influenza infection is more likely to increase respiratory morbidity and mortality. This study aimed to assess exacerbated inflammatory effects posed by secondary pneumococcal pneumonia, given prior influenza infection. MATERIALS AND METHODS: A well-derived mathematical within-host dynamic model of coinfection with influenza A virus and Streptococcus pneumoniae (SP) integrated with dose-response relationships composed of previously published mouse experimental data and clinical studies was implemented to study potentially exacerbated inflammatory responses in pneumonia based on a probabilistic approach...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28740349/functional-lipidomics-in-patients-on-home-parenteral-nutrition-effect-of-lipid-emulsions
#13
Loris Pironi, Mariacristina Guidetti, Ornella Verrastro, Claudia Iacona, Federica Agostini, Caterina Pazzeschi, Anna Simona Sasdelli, Michele Melchiorre, Carla Ferreri
AIM: To investigate the fatty acid-based functional lipidomics of patients on long-term home parenteral nutrition receiving different intravenous lipid emulsions. METHODS: A cross-sectional comparative study was carried out on 3 groups of adults on home parenteral nutrition (HPN), receiving an HPN admixture containing an olive-soybean oil-based intravenous lipid emulsion (IVLE) (OO-IVLE; n = 15), a soybean- medium-chain triacylglycerol-olive-fish oil-based IVLE (SMOF-IVLE; n = 8) or HPN without IVLE (No-IVLE; n = 8) and 42 healthy controls (HCs)...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28740206/relation-between-arterial-stiffness-and-markers-of-inflammation-and-hemostasis-data-from-the-population-based-gutenberg-health-study
#14
Natalie Arnold, Tommaso Gori, Renate B Schnabel, Andreas Schulz, Jürgen H Prochaska, Tanja Zeller, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Christine Espinola-Klein, Karl J Lackner, Stefan Blankenberg, Thomas Münzel, Philipp S Wild
The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739154/prostaglandin-e2-a-pancreatic-fluid-biomarker-of-intraductal-papillary-mucinous-neoplasm-dysplasia
#15
Michele T Yip-Schneider, Rosalie A Carr, Huangbing Wu, C Max Schmidt
BACKGROUND: With the increased frequency of diagnostic imaging, pancreatic cysts are now detected in >3% of American adults. Most of these are intraductal papillary mucinous neoplasm (IPMN) with well-established but variable malignant potential. A biomarker that predicts malignant potential or dysplastic grade would help determine which IPMN require removal or can be safely observed. We previously reported that pancreatic fluid prostaglandin E2 (PGE2) levels may have promise as a predictor of IPMN dysplasia and seek to validate these results in the current study...
July 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28738907/rig-i-expression-in-perifascicular-myofibers-is-a-reliable-biomarker-of-dermatomyositis
#16
Xavier Suárez-Calvet, Eduard Gallardo, Iago Pinal-Fernandez, Noemi De Luna, Cinta Lleixà, Jordi Díaz-Manera, Ricardo Rojas-García, Ivan Castellví, M Angeles Martínez, Josep M Grau, Albert Selva-O'Callaghan, Isabel Illa
BACKGROUND: Dermatomyositis (DM) is inflammatory myopathy or myositis characterized by muscle weakness and skin manifestations. In the differential diagnosis of DM the evaluation of the muscle biopsy is of importance among other parameters. Perifascicular atrophy in the muscle biopsy is considered a hallmark of DM. However, perifascicular atrophy is not observed in all patients with DM and, conversely, perifascicular atrophy can be observed in other myositis such as antisynthetase syndrome (ASS), complicating DM diagnosis...
July 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28738850/brain-biomarkers-and-pre-injury-cognition-are-associated-with-long-term-cognitive-outcome-in-children-with-traumatic-brain-injury
#17
Amy A Wilkinson, Maureen Dennis, Nevena Simic, Margot J Taylor, Benjamin R Morgan, Helena Frndova, Karen Choong, Craig Campbell, Douglas Fraser, Vicki Anderson, Anne-Marie Guerguerian, Russell Schachar, Jamie Hutchison
BACKGROUND: Children with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injury severity, age at injury and sex, prognostication of outcome remains imperfect at a patient-specific level. The objective of this proof of principle study was to evaluate a variety of patient variables, along with six brain-specific and inflammatory serum protein biomarkers, as predictors of long-term cognitive outcome following paediatric TBI...
July 24, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28738836/metabolism-associated-danger-signal-induced-immune-response-and-reverse-immune-checkpoint-activated-cd40-monocyte-differentiation
#18
REVIEW
Jin Dai, Pu Fang, Jason Saredy, Hang Xi, Cueto Ramon, William Yang, Eric T Choi, Yong Ji, Wei Mao, Xiaofeng Yang, Hong Wang
Adaptive immunity is critical for disease progression and modulates T cell (TC) and antigen-presenting cell (APC) functions. Three signals were initially proposed for adaptive immune activation: signal 1 antigen recognition, signal 2 co-stimulation or co-inhibition, and signal 3 cytokine stimulation. In this article, we propose to term signal 2 as an immune checkpoint, which describes interactions of paired molecules leading to stimulation (stimulatory immune checkpoint) or inhibition (inhibitory immune checkpoint) of an immune response...
July 24, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28738246/crocin-modulates-il-4-il-13-signaling-and-ameliorates-experimentally-induced-allergic-airway-asthma-in-a-murine-model
#19
Haidy Yosri, Wagdi F Elkashef, Eman Said, Nariman M Gameil
Allergic asthma is a chronic respiratory disease with a prevalent T helper (Th2)-mediated immune reaction. Crocin, the major bioactive constituent of saffron, has been reported in multiple studies to have numerous pharmacological activities, including prominent anti-oxidant activities. In the current study, the anti-asthmatic potential of crocin was evaluated. Adult male Swiss Albino mice were administered 10mg of ovalbumin (OVA) mixed with 1mg of aluminum hydroxide intraperitoneally on days 0 and 7 and were administered crocin (25mg/kg) orally daily for 16days...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28738231/sliding-strip-microfluidic-device-enables-elisa-on-paper
#20
Mohit S Verma, Maria-Nefeli Tsaloglou, Tyler Sisley, Dionysios Christodouleas, Austin Chen, Jonathan Milette, George M Whitesides
This article describes a 3D microfluidic paper-based analytical device that can be used to conduct an enzyme-linked immunosorbent assay (ELISA). The device comprises two parts: a sliding strip (which contains the active sensing area) and a structure surrounding the sliding strip (which holds stored reagents-buffers, antibodies, and enzymatic substrate-and distributes fluid). Running an ELISA involves adding sample (e.g. blood) and water, moving the sliding strip at scheduled times, and analyzing the resulting color in the sensing area visually or using a flatbed scanner...
July 19, 2017: Biosensors & Bioelectronics
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