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P. gingivalis

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https://www.readbyqxmd.com/read/27919160/kr12-peptide-associated-with-cyclodextrin-antimicrobial-and-antitumor-activities
#1
Karina I R Teixeira, Maria E Cortés, Robson A S Santos, Fábio de Oliveira, Ruben D Sinisterra
The aim of this study was to determine the physical properties and antimicrobial and antiproliferative effects of the KR12 peptide complexed with 2-hydroxypropyl-β-cyclodextrin (Hp-βCd) in vitro. The KR12:Hp-βCd composition was evaluated for particle size and its zeta (ζ)-potential in the presence and absence of cells. Antimicrobial activity against Streptococcus mutans, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis for the peptide alone or associated was evaluated by minimal inhibitory concentration...
December 1, 2016: Biointerphases
https://www.readbyqxmd.com/read/27916762/induction-of-antibody-response-in-the-oral-cavity-of-dogs-following-intraocular-eye-drop-immunization-with-porphyromonas-gingivalis-cell-lysate-incorporated-in-ph-sensitive-fusogenic-polymer-modified-liposomes
#2
Yosuke Shimizu, Tadashi Iwasaki, Tomoko Tajima, Eiji Yuba, Kenji Kono, Shinobu Watarai
Induction of mucosal immune responses against Porphyromonas gingivalis within the oral cavity of dogs was studied by immunizing with pH-sensitive fusogenic polymer (MGluPG)-modified liposome-associated cell lysate. Dogs immunized with P. gingivalis cell lysate-containing MGluPG-modified liposomes by intraocular (eye drop) route displayed significant levels of P. gingivalis cell lysate-specific serum IgG and IgA as well as mucosal IgA antibodies in saliva secretion. Serum and salivary antibodies generated by intraocularly immunized with MGluPG-modified liposome-associated P...
December 5, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27913143/innate-immune-stimulatory-activity-of-porphyromonas-gingivalis-fimbriae-is-eliminated-by-phase-separation-using-triton-x-114
#3
Kohji Nozoe, Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura
Fimbriae are virulence factors of Porphyromonas gingivalis (P. gingivalis). In this study, the action of fimbriae on neutrophil respiratory burst and cytokine production by mononuclear cells (MNC) were investigated. Native or denatured form of purified P. gingivalis fimbriae contained endotoxin at an equivalence of 1-3μglipopolysaccharides(LPS)/mg protein. The endotoxin could be reduced to the equivalent of 1ng-LPS/mg protein by phase separation using Triton X-114. Unfractionated fimbriae caused serum-dependent priming of neutrophils for enhanced respiratory burst, but both native and denatured forms of Triton X-114-fractionated fimbriae were not active at 100μg/mL...
November 30, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27907988/kr12-peptide-associated-with-cyclodextrin-antimicrobial-and-antitumor-activities
#4
Karina I R Teixeira, Maria E Cortés, Robson A S Santos, Flávio Oliveira, Ruben D Sinisterra
The aim of this study was to determine the physical properties and antimicrobial and antiproliferative effects of the KR12 peptide complexed with 2-hydroxypropyl-β-cyclodextrin (Hp-βCd) in vitro. The KR12:Hp-βCd composition was evaluated for particle size and its zeta (ζ)-potential in the presence and absence of cells. Antimicrobial activity against Streptococcus mutans, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis for the peptide alone or associated was evaluated by minimal inhibitory concentration...
December 1, 2016: Biointerphases
https://www.readbyqxmd.com/read/27901209/effect-of-resveratrol-on-periodontal-pathogens-during-experimental-periodontitis-in-rats
#5
Fabiano Ribeiro Cirano, Renato Correa Viana Casarin, Fernanda Vieira Ribeiro, Marcio Zaffalon Casati, Suzana Peres Pimentel, Tiago Taiete, Maria Martha Bernardi
The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27890593/evaluation-of-the-crystal-structure-of-a-fimbrillin-fima-from-porphyromonas-gingivalis-as-a-therapeutic-target-for-photo-activated-disinfection-with-toluidine-blue-o
#6
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Porphyromonas gingivalis is one of the etiological agents in the initiation of combined periodontal-endodontic (perio-endo) lesions. Successful treatment of perio-endo lesions with photo-activated disinfection (PAD) as a novel therapeutic approach depends on the selection of an appropriate target site, specific photosensitizer (PS), and wavelength of light. Since the fimbrillin (FimA) is the most important pathogenic agent in P. gingivalis it was evaluated as a target site against PAD with toluidine blue O (TBO) as a PS...
November 23, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888369/prevalence-of-periodontal-pathogens-as-predictor-of-the-evolution-of-periodontal-status
#7
Miriam Puig-Silla, José María Montiel-Company, Francisco Dasí-Fernández, José Manuel Almerich-Silla
The aim of this study was to determine the relationship between the prevalence of Porphyromonas gingivalis, its fimA genotypes, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola and the evolution of periodontal health. In a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. PCR was employed to determine the presence of the periodontopathogenic bacteria...
November 25, 2016: Odontology
https://www.readbyqxmd.com/read/27885966/er-cr-ysgg-laser-effectively-ablates-single-species-biofilms-on-titanium-disks-without-detectable-surface-damage
#8
Jason M Strever, Jaebum Lee, William Ealick, Mark Peacock, Daniel Shelby, Cristiano Susin, Donald Mettenberg, Ahmed El-Awady, Frederick Rueggeberg, Christopher W Cutler
BACKGROUND: Increasing evidence implicates biofilms, consisting of species such as Porphyromonas gingivalis, in the etiology of peri-implantitis. Multiple approaches to ablate biofilms on failing implants have been proposed, include the use of lasers; most recently the Er,Cr:YSGG laser. The purpose of this study is to establish an in-vitro single-species biofilm model on implant surfaces and determine power settings of the Er,Cr:YSGG laser that remove the biofilm while not causing physical damage to the disk...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27885964/porphyromonas-gingivalis-capsule-mediated-coaggregation-as-a-virulence-factor-in-mixed-infection-with-fusobacterium-nucleatum
#9
David Polak, Oren Ferdman, Yael Houri-Haddad
BACKGROUND: Porphyromonas gingivalis capsule enables evasion from phagocytosis, invasion of keratinocytes and bacterial survival. In mixed infection, the capsule also participates in coaggregation, which may lead to characteristic virulence not present in the mono-infection. The aim of the study was to evaluate the role of P.gingivalis capsule as a virulence factor in co-aggregated mixed infection with Fusobacterium nucleatum. METHODS: Mixed infections containing F...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27883084/nucleoside-diphosphate-kinase-of-p-gingivalis-is-secreted-from-epithelial-cells-in-the-absence-of-a-leader-sequence-through-a-pannexin-1-interactome
#10
Kalina Atanasova, Jungnam Lee, JoAnn Roberts, Kyulim Lee, David M Ojcius, Özlem Yilmaz
Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes. The mode(s) of NDK secretion is currently undefined, while extracellular translocation of bacterial NDKs is critical for avoidance of host pathogen clearance by opportunistic pathogens such as Porphyromonas gingivalis. P. gingivalis-NDK during infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial cells (GECs) via eATP hydrolysis. Furthermore, depletion of pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release in GECs, and P...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882863/porphyromonas-gingivalis-suppresses-adaptive-immunity-in-periodontitis-atherosclerosis-and-alzheimer-s-disease
#11
REVIEW
Ingar Olsen, Martin A Taubman, Sim K Singhrao
Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has been found to associate with remote body organ inflammatory pathologies, including atherosclerosis and Alzheimer's disease (AD). Although P. gingivalis has a plethora of virulence factors, much of its pathogenicity is surprisingly related to the overall immunosuppression of the host. This review focuses on P. gingivalis aiding suppression of the host's adaptive immune system involving manipulation of cellular immunological responses, specifically T cells and B cells in periodontitis and related conditions...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27876716/-the-relationship-of-molecular-genetic-markers-with-clinical-signs-and-risk-factors-of-periodontitis
#12
O A Zorina, N K Aimadinova, A A Basova, D V Rebrikov
The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27875793/detection-and-quantification-of-aggregatibacter-actinomycetemcomitans-porphyromonas-gingivalis-and-streptococcus-oralis-in-blood-samples-with-different-microbiological-identification-methods-an-in-vitro-study
#13
María José Marin, Nagore Ambrosio, Leire Virto, Pedro Diz, Maximiliano Álvarez, David Herrera, Mariano Sanz, Elena Figuero
BACKGROUND: Culture-based methods (culture broth bottles or lysis methods) have been the standard for detecting bacteremia. More recently, quantitative polymerase chain reaction (qPCR) was proposed as a more sensitive and specific test although none of them has been validated for the identification of periodontal pathogens (fastidious growing bacteria) in blood samples. OBJECTIVE: To compare the ability to detect and quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Streptococcus oralis (alone or in combination) in blood samples with three culture techniques [direct anaerobic culturing (DAC), haemo-culture (BACTEC), and lysis-centrifugation (LC)] and a non-culture dependent approach (qPCR) in an in vitro study...
November 9, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27858553/cross-sectional-evaluation-of-periodontal-status-microbiological-and-rheumatoid-parameters-in-a-large-cohort-of-patients-with-rheumatoid-arthritis
#14
Jan Schmickler, Annegret Rupprecht, Susann Patschan, Daniel Patschan, Gerhard A Müller, Rainer Haak, Rainer F Mausberg, Gerhard Schmalz, Tanja Kottmann, Dirk Ziebolz
BACKGROUND: This study evaluates periodontal conditions and microbiological findings and their influence on rheumatological disease parameters in patients with rheumatoid arthritis (RA). METHODS: 168 RA-patients were included. A healthy control group (HC, n=168) was composed according to age, gender and smoking habits. Rheumatological data (duration of illness, DAS28, RF, aCCP, medications) were extracted from patients' records. Dental examination included: dental findings (DMF-T), gingival inflammation (PBI), periodontal status (probing depth [PD], attachment loss [AL])...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27858552/fluvastatin-inhibits-osteoclast-differentiation-and-p-gingivalis-lipopolysaccharide-induced-alveolar-bone-erosion-in-mice
#15
Nitin Kumar Pokhrel, Yong-Gun Kim, Jae-Young Kim, Hong-Hee Kim, Youngkyun Lee
BACKGROUND: Statins have been widely used to treat hypercholesterolemia. In addition to the inhibition of cholesterol synthesis, recent reports suggest bone anabolic property of statins. However, little notice has been paid to the direct effect of statins on osteoclastogenesis and bone resorption. METHODS: The effect of fluvastatin on osteoclast differentiation was determined using in vitro culture of mouse bone marrow macrophages (BMMs) in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa B ligand (RANKL)...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27849177/the-interplay-of-tlr9-myeloid-cells-and-a20-in-periodontal-inflammation
#16
Katie E Crump, Jennifer C Oakley, Xia Xia-Juan, Theandra C Madu, Swathi Devaki, Erin C Mooney, Sinem E Sahingur
TLR9 deficient (TLR9(-/-)) mice are resistant to periodontitis, a disease characterized by a dysbiotic microbiota and deregulated immune response resulting in tooth loss and various systemic conditions. However, the mechanisms and biological pathways by which TLR9 instigates periodontal inflammation are yet to be identified. In a ligature-induced model of periodontitis, we demonstrate TLR9(-/-) mice exhibited significantly less alveolar bone loss compared to their wild-type (WT) counterparts. Consistent with the disease phenotype, gingival tissues showed significantly more inflammatory cell infiltrate in the WT ligated but not in the TLR9(-/-) ligated mice compared to their unligated controls...
November 14, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27842841/nanofibers-containing-tetracycline-%C3%AE-cyclodextrin-physico-chemical-characterization-and-antimicrobial-evaluation
#17
Ana P F Monteiro, Cíntia M S L Rocha, Michele F Oliveira, Sávio M L Gontijo, Ricardo R Agudelo, Rubén D Sinisterra, Maria E Cortés
This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27834922/bee-venom-inhibits-porphyromonas-gingivalis-lipopolysaccharides-induced-pro-inflammatory-cytokines-through-suppression-of-nf-%C3%AE%C2%BAb-and-ap-1-signaling-pathways
#18
Woon-Hae Kim, Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Jae-Bok Park, Woo Jung Sung, Yong-Chul Kwon, Kyung-Duck Park, Sang Mi Han, Kwan-Kyu Park
Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), is one of major pathogens that cause periodontitis. Bee venom (BV) has been widely used as a traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects of BV. However, a direct role and cellular mechanism of BV on periodontitis-like human keratinocytes have not been explored...
November 10, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27832944/caffeic-acid-phenethyl-ester-attenuates-lipopolysaccharide-stimulated-proinflammatory-responses-in-human-gingival-fibroblasts-via-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathway
#19
Lei Li, Wei Sun, Tao Wu, Rui Lu, Bin Shi
Periodontal diseases often begin with chronic gingival inflammation, which causes the destruction of periodontal tissues. Inflammatory immune responses from host cells to bacteria, such as Porphyromonas gingivalis (P. gingivalis), cause periodontal degradation. Human gingival fibroblasts (HGFs) are the major cells in periodontal soft tissues. When stimulated by lipopolysaccharide (LPS), HGFs could secrete several pro-inflammatory cytokines and chemokines, such as interleukins (ILs) IL-6, IL-8, inducible nitric oxide synthase (iNOS), and cyclooxygenase 2 (COX-2)...
November 7, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27829746/evaluation-of-efficacy-of-probiotic-bifilac-on-porphyromonas-gingivalis-in-vitro-study
#20
Sugumari Elavarasu, Thangakumaran Suthanthiran, Arthiie Thangavelu, Shiva Shangkharii Kanagaraj, Lakshmi Mohandas, Santhosh Sekar
BACKGROUND: Periodontitis is inflammation of the periodontium and causes destruction of the connective tissue attachment of the teeth and alveolar bone. Porphyromonas gingivalis is the primary pathogen for the destructive periodontal diseases. The aim of the study is to evaluate the efficacy of probiotic on P. gingivalis. MATERIALS AND METHODS: An in vitro study was done to analyze the effectiveness of probiotic BIFILAC on P. gingivalis was determined using disc diffusion method...
October 2016: Journal of Pharmacy & Bioallied Sciences
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