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P. gingivalis

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https://www.readbyqxmd.com/read/28099577/effects-of-periodontal-treatment-on-primary-sj%C3%A8-gren-s-syndrome-symptoms
#1
Lucas Macedo Batitucci Ambrósio, Emanuel da Silva Rovai, Bruno Nunes de França, Danilo Andrés Balzarini, Ieda Santos Abreu, Sheyla Batista Bologna Lopes, Thaís Borguezan Nunes, Silvia Vanessa Lourenço, Sandra Gofinet Pasoto, Luciana Saraiva, Marinella Holzhausen
The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively)...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28095260/differential-expression-and-roles-of-secreted-frizzled-related-protein-5-and-the-wingless-homolog-wnt5a-in-periodontitis
#2
T Maekawa, P Kulwattanaporn, K Hosur, H Domon, M Oda, Y Terao, T Maeda, G Hajishengallis
The Wingless/integrase-1 (Wnt) family of protein ligands and their functional antagonists, secreted frizzled-related proteins (sFRPs), regulate various biological processes ranging from embryonic development to immunity and inflammation. Wnt5a and sFRP5 comprise a typical ligand/antagonist pair, and the former molecule was recently detected at the messenger RNA (mRNA) level in human periodontitis. The main objective of this study was to investigate the interrelationship of expression of Wnt5a and sFRP5 in human periodontitis (as compared to health) and to determine their roles in inflammation and bone loss in an animal model...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28093069/assessing-the-progression-of-chronic-periodontitis-using-subgingival-pathogen-levels-a-24-month-prospective-multicenter-cohort-study
#3
E Kakuta, Y Nomura, T Morozumi, T Nakagawa, T Nakamura, K Noguchi, A Yoshimura, Y Hara, O Fujise, F Nishimura, T Kono, M Umeda, M Fukuda, T Noguchi, N Yoshinari, C Fukaya, S Sekino, Y Numabe, N Sugano, K Ito, H Kobayashi, Y Izumi, H Takai, Y Ogata, S Takano, M Minabe, A Makino-Oi, A Saito, Y Abe, S Sato, F Suzuki, K Takahashi, T Sugaya, M Kawanami, N Hanada, S Takashiba, H Yoshie
BACKGROUND: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. METHODS: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care...
January 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28092794/%C3%AE-defensin-3-modulates-macrophage-activation-and-orientation-during-acute-inflammatory-response-to-porphyromonas-gingivalis-lipopolysaccharide
#4
Jinglu Lyu, Tianying Bian, Bin Chen, Di Cui, Lili Li, Ling Gong, Fuhua Yan
β-defensin 3, a multifunctional antimicrobial peptide, has immuno-regulatory activities. We investigated the modulatory mechanism of human β-defensin 3 (hBD3) on acute inflammatory response resulted from Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), which plays a pro-inflammatory role in periodontal infection and its derived systemic inflammation. P.g-LPS was administrated to mice and murine macrophages alone or along with hBD3. P.g-LPS could lead to acute inflammation as soon as 2h. And it was observed that hBD3 significantly decreased the production of pro-inflammatory biomarkers of in response to P...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28087617/in-vitro-activity-of-the-antiasthmatic-drug-zafirlukast-against-the-oral-pathogens-porphyromonas-gingivalis-and-streptococcus-mutans
#5
Evelien Gerits, Isolde Van der Massen, Katleen Vandamme, Kaat De Cremer, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Serge Beullens, Maarten Fauvart, Natalie Verstraeten, Jan Michiels
Oral infections are among the most common diseases worldwide. Many protocols for the prevention and treatment of oral infections have been described, yet no golden standard has been developed so far. The antiseptic chlorhexidine and antibiotics are often used in these treatment procedures. However, long-term use of chlorhexidine can lead to side effects and extensive use of antibiotics can promote the development of antibiotic-resistant bacteria, which in turn can compromise the effectiveness of the treatment...
January 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28081372/role-of-hyperplasia-of-gingival-lymphatics-in-periodontal-inflammation
#6
P Papadakou, A Bletsa, M A Yassin, T V Karlsen, H Wiig, E Berggreen
Lymphatic vessels are important for maintenance of tissue fluid homeostasis and afferent antigen transport. In chronic inflammation, lymphangiogenesis takes place and is characterized by lymphatic endothelial cell proliferation and lymphatic hyperplasia. Vascular endothelial growth factor C (VEGFC) is the main known lymphangiogenic growth factor, and its expression is increased in periodontitis, a common chronic infectious disease that results in tissue destruction and alveolar bone loss. The role of lymphangiogenesis during development of periodontitis is unknown...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/28076463/in-vitro-effects-of-melaleuca-alternifolia-essential-oil-on-growth-and-production-of-volatile-sulphur-compounds-by-oral-bacteria
#7
Talita Signoreti Graziano, Caroline Morini Calil, Adilson Sartoratto, Gilson César Nobre Franco, Francisco Carlos Groppo, Karina Cogo-Müller
Objective: Halitosis can be caused by microorganisms that produce volatile sulphur compounds (VSCs), which colonize the surface of the tongue and subgingival sites. Studies have reported that the use of natural products can reduce the bacterial load and, consequently, the development of halitosis. The aim of this study was to evaluate the antimicrobial activity of the essential oil of Melaleuca alternifolia on the growth and volatile sulphur compound (VSC) production of oral bacteria compared with chlorhexidine...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28067105/antimicrobial-effects-of-mastic-extract-against-oral-and-periodontal-pathogens
#8
Stefka Koychev, Henrik Dommisch, Hong Chen, Nicole Pischon
BACKGROUND: Various antimicrobial agents are widely used in the therapy of oral inflammatory diseases. However, their side effects and the appearance of drug resistance justify research on natural antimicrobial agents to target oral pathogens that are safe for the host. In the present study, antimicrobial properties of mastic extract on commensal and pathogenic oral bacteria, as well as its possible cytotoxic effect toward cells of epithelial and mesenchymal origin, were evaluated in comparison to the common antimicrobial agents hydrogen peroxide (H2O2) and chlorhexidine digluconate (CHX)...
January 8, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28063227/lipus-suppressed-lps-induced-il-1%C3%AE-through-the-inhibition-of-nf-%C3%AE%C2%BAb-nuclear-translocation-via-at1-plc%C3%AE-pathway-in-mc3t3-e1
#9
Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Masako Naito, Kumiko Nakai, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Masao Maeno, Naoto Suzuki, Shuichi Sato
Inflammatory cytokines, interleukin (IL)-1, IL-6, and TNF-a, are involved in inflammatory bone diseases such as rheumatoid osteoarthritis and periodontal disease. Particularly, periodontal disease, which destroys alveolar bone, is stimulated by lipopolysaccharide (LPS). Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dental treatments. However,the mechanism underlying effects of LIPUS on LPS-induced inflammatory cytokine are not well understood. We therefore aimed to investigate the role of LIPUS on LPS-induced IL-1a production...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28056810/porphyromonas-gingivalis-activates-nf%C3%AE%C2%BAb-and-mapk-pathways-in-human-oral-epithelial-cells
#10
Sabine Groeger, Fabian Jarzina, Eugen Domann, Joerg Meyle
BACKGROUND: The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activation of signaling cascades in primary epithelial cells and oral cancer cell lines by a profiler PCR array. RESULTS: After infection with P. gingivalis membranes the RNA of 16 to 33 of 84 key genes involved in the antibacterial immune response was up-regulated, amongst them were IKBKB (NF-κB signaling pathway), IRF5 (TLR signaling) and JUN, MAP2K4, MAPK14 and MAPK8 (MAPK pathway) in SCC-25 cells and IKBKB, IRF5, JUN, MAP2K4, MAPK14 and MAPK8 in PHGK...
January 5, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28051836/the-porphyromonas-gingivalis-hemagglutinins-hagb-and-hagc-are-major-mediators-of-adhesion-and-biofilm-formation
#11
E Connolly, E Millhouse, R Doyle, S Culshaw, G Ramage, G P Moran
Porphyromonas gingivalis is a bacterium associated with chronic periodontitis that possesses a family of genes encoding hemagglutinins required for heme acquisition. In this study we generated ΔhagB and ΔhagC mutants in strain W83 and demonstrate that both hagB and hagC are required for adherence to oral epithelial cells. Unexpectedly, a double ΔhagB/ΔhagC mutant had less severe adherence defects than either of the single mutants, but was found to exhibit increased expression of the gingipain-encoding genes rgpA and kgp, suggesting that a ΔhagB/ΔhagC mutant is only viable in populations of cells that exhibit increased expression of genes involved in heme acquisition...
February 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28050493/anti-microbial-efficacy-of-soursop-leaf-extract-annona-muricata-on-oral-pathogens-an-in-vitro-study
#12
Bh Mithun Pai, Gururagavendra Rajesh, Ramya Shenoy, Ashwini Rao
INTRODUCTION: Annona muricata also called as Soursop is a, flowering evergreen tree native to Mexico, Cuba, Central America and parts of India. The miracle tree as it is widely known as a natural cancer killer that is 10,000 times stronger than chemotherapy. Based on these miraculous claims, the leaves of these plants were used as an extract at varying concentrations as an antibacterial agent against oral pathogens. AIM: The aim of the study was to assess antimicrobial efficacy of Soursop leaf extarct (Annona muricata) on Streptococcus mutans, Streptococcus mitis, Porphyromonas gingivalis, Prevotella intermedia and Candida albicans using disc diffusion method...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28030574/endothelin-regulates-porphyromonas-gingivalis-induced-production-of-inflammatory-cytokines
#13
Ga-Yeon Son, Eun-Jung Bak, Ji-Hye Kim, Dong Eun Lee, Si-Mook Kang, So Yun Lee, Lin Choi, Ji Su Sun, Seul Ki Kim, Wonse Park, Baek Il Kim, Yun-Jung Yoo, Inik Chang, Dong Min Shin
Periodontitis is a very common oral inflammatory disease that results in the destruction of supporting connective and osseous tissues of the teeth. Although the exact etiology is still unclear, Gram-negative bacteria, especially Porphyromonas gingivalis in subgingival pockets are thought to be one of the major etiologic agents of periodontitis. Endothelin (ET) is a family of three 21-amino acid peptides, ET-1, -2, and -3, that activate G protein-coupled receptors, ETA and ETB. Endothelin is involved in the occurrence and progression of various inflammatory diseases...
2016: PloS One
https://www.readbyqxmd.com/read/28028684/are-obesity-acpas-and-periodontitis-conditions-that-influence-the-risk-of-developing-rheumatoid-arthritis-in-first-degree-relatives
#14
Sonia Unriza-Puin, Wilson Bautista-Molano, Gloria I Lafaurie, Rafael Valle-Oñate, Philippe Chalem, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sánchez
The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P...
December 28, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28027940/cholesterol-in-situ-forming-gel-loaded-with-doxycycline-hyclate-for-intra-periodontal-pocket-delivery
#15
Thawatchai Phaechamud, Orn Setthajindalert
Cholesterol has been widely used in drug delivery systems including implant. Doxycycline hyclate (DH)-loaded cholesterol in situ forming gels using N-methyl pyrrolidone as a solvent were prepared and investigated for their properties including viscosity, rheology, syringeability, gel formation, drug release, degradation and antimicrobial activities. The burst drug release of a DH-loaded in situ forming gel using cholesterol as the gelling agent was minimized when the amount of benzyl benzoate was increased...
December 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27999400/comparative-study-on-the-characteristics-of-weissella-cibaria-cmu-and-probiotic-strains-for-oral-care
#16
Hye-Jin Jang, Mi-Sun Kang, Sung-Hun Yi, Ji-Young Hong, Sang-Pil Hong
Probiotics have been demonstrated as a new paradigm to substitute antibiotic treatment for dental caries, gingivitis, and chronic periodontitis. The present work was conducted to compare the characteristics of oral care probiotics: Weissella cibaria CMU (Chonnam Medical University) and four commercial probiotic strains. Survival rates under poor oral conditions, acid production, hydrogen peroxide production, as well as inhibition of biofilm formation, coaggregation, antibacterial activity, and inhibition of volatile sulfur compounds were evaluated...
December 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27994415/detection-of-porphyromonas-gingivalis-and-treponema-denticola-in-chronic-and-aggressive-periodontitis-patients-a-comparative-polymerase-chain-reaction-study
#17
Ramniwas M Kumawat, Sindhu M Ganvir, Vinay K Hazarey, Asifa Qureshi, Hemant J Purohit
BACKGROUND: The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and aggressive periodontitis (AgP) is not explored well in Indian population. AIM: The study was undertaken to detect P. gingivalis and T. denticola in CP as well as in AgP patients using polymerase chain reaction (PCR), and to determine the relationship between the frequency of these two microorganisms and the severity of clinical periodontal parameters...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27993858/repurposing-toremifene-for-the-treatment-of-oral-bacterial-infections
#18
Evelien Gerits, Valerie Defraine, Katleen Vandamme, Kaat De Cremer, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Serge Beullens, Maarten Fauvart, Natalie Verstraeten, Jan Michiels
The spread of antibiotic resistance and the challenges associated with antiseptics such as chlorhexidine have necessitated the search for new antibacterial agents against oral bacterial pathogens. As a result of failing traditional approaches, drug repurposing has emerged as a novel paradigm to find new antibacterial agents. In this study, we examined the effect of the FDA-approved anticancer agent toremifene against oral bacteria Porphyromonas gingivalis and Streptococcus mutans. We found that the drug was able to inhibit growth of both pathogens as well as prevent biofilm formation at concentrations ranging from 12...
December 19, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27993634/an-ex-vivo-evaluation-of-the-efficacy-of-andrographolide-in-modulating-differential-expression-of-transcription-factors-and-target-genes-in-periodontal-cells-and-its-potential-role-in-treating-periodontal-diseases
#19
Ambili R, Prasanthila Janam, P S Saneesh Babu, Manu Prasad, D Vinod, P R Anil Kumar, T V Kumary, S Asha Nair, M Radhakrishna Pillai
ETHANOPHARMACOLOGICAL RELEVANCE: Andrographolide is a herbal extract traditionally used in South Asian countries for treating inflammatory diseases. AIM OF THE STUDY: To evaluate the efficacy of andrographolide in management of periodontal disease which is a highly prevalent oral disease. MATERIALS AND METHODS: Periodontal ligament fibroblasts (PDLF) were cultured from healthy and diseased periodontium using explant culture methods. The safe dose of AG was determined using MTT assay...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27987467/fucoidan-inhibits-lps-induced-inflammation-in-vitro-and-during-the-acute-response-in-vivo
#20
Jisang Park, Jeong-Dan Cha, Kyung-Min Choi, Kyung-Yeol Lee, Kang Min Han, Yong-Suk Jang
Studies have been focused on natural products with antibacterial and anti-inflammatory activities, such as fucoidan. Many in vivo studies have evaluated the effect of fucoidan on tumor growth, diabetes, obesity, ischemia reperfusion, and oxidative stress. However, the effects of fucoidan on bacteria-induced gingival inflammation and periodontitis have not been reported. We previously characterized the anti-inflammatory effect of fucoidan in vitro. Here, we confirmed the anti-inflammatory activity of fucoidan in a macrophage cell line in terms of its inhibition of the expression of inflammatory mediators and pro-inflammatory cytokines...
February 2017: International Immunopharmacology
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