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P. gingivalis

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https://www.readbyqxmd.com/read/29786143/impact-of-commensal-flora-on-periodontal-immune-response-to-lipopolysaccharide
#1
Daiki Fukuhara, Koichiro Irie, Yoko Uchida, Kota Kataoka, Kentaro Akiyama, Daisuke Ekuni, Takaaki Tomofuji, Manabu Morita
BACKGROUND: Commensal flora are involved in the appropriate development of the mature immune system. However, it is unclear how commensal flora contribute to immune responses against periodontal pathogens, including the response to lipopolysaccharide (LPS). The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in germ-free (GF) and specific-pathogen-free (SPF) mice. METHODS: GF and SPF mice at 8 weeks of age were randomly divided into four groups each: a baseline group (n = 4/group) and three experimental groups (n = 6/group)...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29786138/association-of-different-immunosuppressive-medications-with-periodontal-condition-in-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-study
#2
Dirk Ziebolz, Annegret Rupprecht, Jan Schmickler, Laura Bothmann, Juliane Krämer, Daniel Patschan, Gerhard A Müller, Rainer F Mausberg, Jana Schmidt, Gerhard Schmalz, Susann Patschan
BACKGROUND: The aim of this cross-sectional study was to investigate clinical periodontal findings as well as prevalence of selected potentially periodontal pathogenic bacteria in patients with rheumatoid arthritis (RA) treated with different immunosuppressive rheumatic medications. METHODS: 168 patients with RA undergoing different immunosuppressive medications were included and divided into subgroups according to their medication, which was taken in the past six months, in detail I) non-steroidal anti-inflammatory drugs (NSAID) and glucocorticoids combined, and II-VII) different disease modifying anti-rheumatic drugs (DMARDs): II) Methotrexate (MTX), III) Leflunomide, IV) MTX and TNF-α antagonists combined, V) Interleukin-6 (IL-6) antagonist, VI) MTX and Rituximab combined, and VII) combination therapies of more than two of these DMARDs...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29779263/effects-of-porphyromonas-gingivalis-lps-and-lr12-peptide-on-trem-1-expression-by-monocytes
#3
M Dubar, K Carrasco, S Gibot, C Bisson
Periodontal disease involves the activation of host immune response, acting not only as defender of periodontal tissues against bacterial aggression but also as mediator of tissue destruction. Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is an immune receptor that synergizes with Toll-like receptors in amplifying the inflammatory response mediated by microbial molecules. AIM: To investigate the role of P. gingivalis lipopolysaccharide (LPS) and the effect of LR12, a TREM-1 inhibitory peptide, on the expression of membrane-bound and soluble form of TREM-1 on human primary monocytes, as well as the production of pro-inflammatory cytokines...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29771309/identification-of-a-specific-domain-of-porphyromonas-gingivalis-hgp44-responsible-for-adhesion-to-treponema-denticola
#4
Kouki Yoshikawa, Yuichiro Kikuchi, Eitoyo Kokubu, Kentaro Imamura, Atsushi Saito, Kazuyuki Ishihara
Interaction between two periodontal pathogens, Porphyromonas gingivalis and Treponema denticola, contributes to plaque biofilm formation. P. gingivalis forms aggregates with T. denticola through its adhesion/hemagglutinin domain (Hgp44). In this study, we investigated the specific domain of P. gingivalis Hgp44 responsible for adhesion to T. denticola using expression vectors harboring P. gingivalis Hgp44 DNA sequences encoding amino acid residues 1-419. Six plasmids harboring fragments in this region were generated by PCR amplification and self-ligation, and recombinant proteins r-Hgp44 (residues 1-419), r-Hgp441 (residues 1-124), r-Hgp442 (1-199), r-Hgp443 (1-316), r-Hgp444 (199-419), r-Hgp445 (124-198), and r-Hgp446 (199-316) were produced, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting...
May 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29770236/magnoliae-cortex-and-maize-modulate-porphyromonas-gingivalis-induced-inflammatory-reactions
#5
Jae-Yoon Kim, Kyoung-Hwa Kim, Eun-Hye Kwag, Yang Jo Seol, Yong Moo Lee, Young Ku, In-Chul Rhyu
Purpose: The aim of this study was to evaluate the capacity of single and combined applications of the bark of the stems and roots of Magnolia officinalis Rehd. et Wils. (Magnoliae Cortex) and Zea mays L. (maize) to modulate inflammation in RAW 264.7 cells stimulated with Porphyromonas gingivalis . Methods: RAW 264.7 cells were stimulated with P. gingivalis , and Magnoliae Cortex and/or maize was added. Cytotoxicity and the capacity to modulate inflammation were determined with a methylthiazol tetrazolium (MTT) assay, nitrite production, enzyme-linked immunosorbent assay (ELISA), and western blotting...
April 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29766714/the-outer-membrane-vesicle-proteome-of-porphyromonas-gingivalis-is-differentially-modulated-relative-to-the-outer-membrane-in-response-to-heme-availability
#6
Paul D Veith, Caroline Luong, Keng H Tan, Stuart G Dashper, Eric C Reynolds
Porphyromonas gingivalis is an anaerobic, Gram-negative oral pathogen associated with chronic periodontitis. P. gingivalis has an obligate requirement for heme which it obtains from the host. Heme availability has been linked to disease initiation and progression. In this study we used continuous culture of the bacterium to determine the effect of heme limitation and excess on the P. gingivalis proteome. Four biological replicates of whole cell lysate (WCL) and outer membrane vesicle (OMV) samples were digested with trypsin and analysed by tandem mass spectrometry and MaxQuant label-free quantification...
May 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29760819/antibacterial-and-anti-inflammatory-potential-of-morus-alba-stem-extract
#7
Ichaya Yiemwattana, Niratcha Chaisomboon, Kusuma Jamdee
Background: Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults. Evidence for the anti inflammatory activity of M. alba Stem Extract (MSE) in periodontal disease is limited. Objective: The study aimed to investigate the inhibitory effect of MSE on the growth of periodontopathic bacteria and expression of interleukin (IL)-6 and IL-8 in Porphyromonas gingivalis Lipopolysaccharide (LPS)-stimulated human Periodontal Ligament (hPDL) fibroblasts...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29760142/-in-vitro-and-in-vivo-activity-of-peptidomimetic-compounds-that-target-the-periodontal-pathogen-porphyromonas-gingivalis
#8
Jinlian Tan, Pravin C Patil, Frederick A Luzzio, Donald R Demuth
The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a discrete motif of the streptococcal antigen I/II protein. A synthetic peptide encompassing this motif functions as a potent inhibitor of P. gingivalis adherence but the use of peptides as topically applied therapeutic agents in the oral cavity has limitations arising from the relatively high cost of peptide synthesis and their susceptibility to degradation by proteases expressed by oral organisms...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29756653/the-effect-of-photodynamic-therapy-on-pathogenic-bacteria-around-peri-implant-sulcus-and-in-the-cavity-between-abutment-and-implant-after-healing-phase-a-prospective-clinical-study
#9
Lin-Yi Zhou, Jun-Yu Shi, Yu Zhu, Shu-Jiao Qian, Hong-Chang Lai, Ying-Xin Gu
OBJECTIVES: To compare levels of pathogens from peri-implant sulcus versus abutment screw cavities after photodynamic therapy. MATERIAL AND METHODS: Twenty patients were included. Photodynamic therapy (PDT) was applied both in sulcus and cavities after sampling following suprastructures loading, and repeated after 2 weeks. Two samples each containing four paper points were collected for each implant at baseline, 2 weeks, 3 months: (i) peri-implant sulcus and (ii) abutment screw cavities...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29754448/periodontal-infection-with-porphyromonas-gingivalis-induces-preterm-birth-and-lower-birth-weight-in-rats
#10
Shanshan Liang, Hongyu Ren, Haiying Guo, Wenyan Xing, Chang Liu, Yaoting Ji, Han Jiang, Ping Zhang, Minquan Du
Preterm birth (PTB), accompanied by low birth weight (LBW) or not, is a syndrome with tremendous risk factors and long-term health consequences for children. In recent decades, overwhelming studies have shown that periodontitis contributes to prematurity and LBW. This study was conducted to determine the link between maternal periodontitis and the pathogenesis of PTB and/or LBW through a rat infection model induced by Porphyromonas gingivalis, an important periodontopathic bacterium. The murine model was established by surgically ligating the left mandibular 1st molars and inoculating with P...
May 13, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29753881/confocal-fluorescence-imaging-to-evaluate-the-effect-of-antimicrobial-photodynamic-therapy-depth-on-p-gingivalis-and-t-denticola-biofilms
#11
Stephen Rogers, Kiyonobu Honma, Thomas S Mang
BACKGROUND: Porphyromonas gingivalis and Treponema denticola are both principally implicated in the incidence of both periodontal disease and peri-implantitis. Recent studies have demonstrated that these bacteria exhibit symbiotic growth in vitro and a synergistic virulence in co-infection of animal models. Found at varying depths throughout the biofilm, these bacteria present a significant challenge to traditional antimicrobial treatment modalities. Antimicrobial photodynamic therapy ( aPDT ) has yielded high success against bacterial biofilms, namely those found in the oral cavity...
May 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29750299/porphyromonas-gingivalis-induced-inflammatory-responses-and-promoted-apoptosis-in-lung-epithelial-cells-infected-with-h1n1-via-the-bcl%C3%A2-2-bax-caspase%C3%A2-3-signaling-pathway
#12
Yongju Chen, Rui Zhou, Zhe Yi, Yonggang Li, Ying Fu, Yibo Zhang, Ping Li, Xin Li, Yaping Pan
The aim of the present study was to investigate the effects of Porphyromonas gingivalis (P. gingivalis) on inflammatory cytokine and nitic oxide (NO) production in lung epithelial cells infected with H1N1, and the underlying mechanisms. Lung epithelial cells were co‑infected with P. gingivalis and H1N1. The concentrations of tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6 were detected via an ELISA, and the concentration of NO was detected by the nitrate reductive enzymatic method at 4, 8, 12 and 24 h following infection...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747062/biochemical-characterization-of-a-recombinant-lactobacillus-acidophilus-strain-expressing-exogenous-foma-protein
#13
Li Ma, Fei Li, Xiangyu Zhang, Xiping Feng
In previous research, to combine the immunogenicity of Fusobacterium nucleatum (F. nucleatum) and the probiotic properties of Lactobacillus acidophilus (L. acidophilus), we constructed a FomA-expressing L. acidophilus strain and assessed its immunogenicity. Our findings indicated that oral administration of the recombinant L. acidophilus strain reduced the risk of periodontal infection by Porphyromonas gingivalis (P. gingivalis) and F. nucleatum. However, because the exogenous FomA is an heterologous protein for the original bacterium, in this study, we assessed whether the biochemical characteristics of the recombinant L...
April 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29744209/the-effect-of-metronidazole-plus-amoxicillin-or-metronidazole-plus-penicillin-v-on-periodontal-pathogens-in-an-in-vitro-biofilm-model
#14
Gabriela Dabija-Wolter, Sundus Saad Al-Zubaydi, Marwan Mansoor Ali Mohammed, Vidar Bakken, Anne Isine Bolstad
A combination of metronidazole (MET) and amoxicillin (AMX) is commonly used as adjunct to mechanical therapy of periodontal disease. The use of broad spectrum antibiotics such as AMX may contribute to development of antibiotic resistance. The aim was to evaluate the in vitro effect of replacing AMX with penicillin V (PV) in combination with MET on a biofilm model. A biofilm model consisting of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum was developed. The biofilms were exposed to AMX + MET and PV + MET in two different concentrations...
February 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29744199/putative-periodontopathic-bacteria-and-herpes-viruses-interactions-in-the-subgingival-plaque-of-patients-with-aggressive-periodontitis-and-healthy-controls
#15
Amal Elamin, Raouf Wahab Ali, Vidar Bakken
The microbial profile of aggressive periodontitis patients is considered to be complex with variations among populations in different geographical areas. The aim of this study was to assess the presences of 4 putative periodontopathic bacteria (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) and 2 periodontal herpes viruses (Epstein-Barr virus type 1 [EBV-1] and human cytomegalovirus [HMCV]) in subgingival plaque of Sudanese subjects with aggressive periodontitis and healthy controls...
October 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29744187/salivary-ammonia-levels-and-tannerella-forsythia-are-associated-with-rheumatoid-arthritis-a-cross-sectional-study
#16
José-Iván Martínez-Rivera, Daniel X Xibillé-Friedmann, Judith González-Christen, Myriam A de la Garza-Ramos, Sandra M Carrillo-Vázquez, José-Luis Montiel-Hernández
The aim of this paper is to evaluate the relationship of salivary ammonium levels and the presence of bacteria with rheumatoid arthritis (RA) clinical disease activity in a cross-sectional study of Mexican patients. From a periodontal and disease activity standpoint, 132 consecutive RA patients fulfilling clinical criteria were evaluated. Ammonia levels (including peptidyl arginine deiminase activity) were evaluated by colorimetric assay and the presence of Porphyromonas gingivalis , Tannerella forsythia , and Prevotella intermedia was evaluated by polymerase chain reaction (PCR) technique...
June 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29736391/the-effects-of-antimicrobial-peptide-nal-p-113-on-inhibiting-periodontal-pathogens-and-improving-periodontal-status
#17
Hongyan Wang, Lisi Ai, Yu Zhang, Jyawei Cheng, Huiyuan Yu, Chen Li, Dongmei Zhang, Yaping Pan, Li Lin
Periodontal disease consists of chronic gingival inflammation characterized by both degradation of the periodontal connective tissue and alveolar bone loss. Drug therapy is used as an auxiliary treatment method in severe chronic periodontitis, aggressive periodontitis, and periodontitis-associated systemic disease. Nal-P-113, a modified antimicrobial peptide, specifically replaces the histidine residues of P-113 with the bulky amino acid β -naphthylalanine, and our previous studies have verified that this novel peptide is not toxic to the human body within a certain concentration range...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29735832/identification-of-multiple-strains-of-porphyromonas-gingivalis-using-heteroduplex-polymerase-chain-reaction-in-varying-severity-of-chronic-periodontitis
#18
Mihir Raghavendra Kulkarni, Kishore G Bhat, Betsy Sara Thomas, G Subraya Bhat, Raghavendra Dhirendra Kulkarni
Aim: Research has demonstrated that there are multiple strains of Porphyromonas gingivalis with varying potency to cause periodontal disease. The current study aims at using heteroduplex polymerase chain reaction (PCR) to detect the strain diversity of P. gingivalis in periodontitis lesions of varying severity in a sample of the Indian population. Materials and Methods: Subgingival plaque samples were collected from 60 individuals with varying severity of chronic periodontitis and 30 individuals with a clinically healthy periodontium...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29731776/potential-of-ipsc-derived-mesenchymal-stromal-cells-for-treating-periodontal-disease
#19
K Hynes, R Bright, V Marino, J Ng, P J Verma, S Gronthos, P M Bartold
Mesenchymal stromal cell-like populations have been derived from mouse-induced pluripotent stem cells (miPSC-MSC) with the capability for tissue regeneration. In this study, murine iPSC underwent differentiation towards an MSC-like immunophenotype. Stable miPSC-MSC cultures expressed the MSC-associated markers, CD73, CD105, and Sca-1, but lacked expression of the pluripotency marker, SSEA1, and hematopoietic markers, CD34 and CD45. Functionally, miPSC-MSC exhibited the potential for trilineage differentiation into osteoblasts, adipocytes, and chondrocytes and the capacity to suppress the proliferation of mitogen-activated splenocytes...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29728546/-in-vitro-antimicrobial-activity-of-ocimum-sanctum-tulsi-extract-on-aggregatibacter-actinomycetemcomitans-and-porphyromonas-gingivalis
#20
Ipsita Jayanti, Md Jalaluddin, Anisha Avijeeta, Pavithra K Ramanna, Pooja M Rai, Rohit A Nair
Aim: The present study was conducted with an aim to assess the antimicrobial activity of Ocimum sanctum (tulsi) extract on Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Materials and methods: Tulsi extract with ethanol was prepared using cold extraction method in the present in vitro study. Various concentrations (2, 4, 6, and 8%) were then obtained by dilution with dimethylformamide. A 0.2% chlorhexidine served as the positive control, whereas the negative control was dimeth-ylformamide...
April 1, 2018: Journal of Contemporary Dental Practice
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