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P. gingivalis

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https://www.readbyqxmd.com/read/28643938/oral-application-of-a-periodontal-pathogen-impacts-serpine1-expression-and-pancreatic-islet-architecture-in-prediabetes
#1
V Ilievski, U G Bhat, S Suleiman-Ata, B A Bauer, P T Toth, S T Olson, T G Unterman, K Watanabe
BACKGROUND AND OBJECTIVES: Epidemiological studies suggest a close association between periodontitis and prediabetes/insulin resistance (IR) but whether periodontitis causes prediabetes in humans is not known. Using various animal models, we have recently established that periodontitis can be an initiator of prediabetes, which is characterized by glucose intolerance, hyperinsulinemia and IR. In addition, our in vitro studies indicated that Porphyromonas gingivalis (Pg) induced insulin secretion in MIN6 β cells and this induction was in part SerpinE1 (plasminogen activator inhibitor 1, PAI1) dependent...
June 23, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28637991/low-intensity-pulsed-ultrasound-inhibits-lipopolysaccharide-induced-il-6-and-rankl-expression-in-osteoblasts
#2
Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Manami Ozaki, Masao Maeno, Naoto Suzuki, Shuichi Sato
Periodontal disease is caused by inflammation induced by Porphyromonas gingivalis (P.g.) lipopolysaccharide (LPS) and involves expression of proinflammatory cytokines such as interleukin (IL)-1, IL-6, tumor necrosis factor-α, and receptor activator of nuclear factor kappa B ligand (RANKL), which are implicated in bone resorption. Low-intensity pulsed ultrasound (LIPUS) is commonly used in the treatment of bone fracture. However, the mechanisms by which LIPUS inhibits LPS-induced inflammatory cytokines are poorly understood...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28637954/increases-in-il-33-production-by-fimbriae-and-lipopeptide-from-porphyromonas-gingivalis-in-mouse-bone-marrow-derived-dendritic-cells-via-toll-like-receptor-2
#3
Hiroyuki Tada, Risako Suzuki, Eiji Nemoto, Hidetoshi Shimauchi, Kenji Matsushita, Haruhiko Takada
Interleukin-33 (IL-33) is an IL-1 cytokine family member that is involved in the development of chronic inflammatory diseases and the initiation of allergic inflammation in response to pathogens. Porphyromonas gingivalis is a primary pathogen that is involved in chronic periodontitis and its bacterial components induce inflammatory responses. Dendritic cells (DCs) recognize pathogen- associated molecular patterns by expression of pattern-recognition receptors, such as Toll-like receptors (TLRs). DCs play an essential role in resistance to infection and maintenance of mucosal immune system...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28637951/porphyromonas-gingivalis-induced-il-33-down-regulates-hcap-18-ll-37-production-in-human-gingival-epithelial-cells
#4
Hiroyuki Tada, Takamitsu Shimizu, Kenji Matsushita, Haruhiko Takada
hCAP-18/LL-37 is an antimicrobial peptide that is mainly expressed in epithelial cells. Gingival epithelial cells play pivotal roles in antimicrobial defense by expressing hCAP-18/LL-37. Porphyromonas gingivalis is a primary pathogen for chronic periodontitis and produces cysteine proteinase gingipains, which induce proinflammatory cytokines production, leading to enhance inflammatory responses. In contrast, gingipains attenuate immune responses, leading to induce anti-inflammatory responses. In this study, we investigated the ability of gingipains to attenuate P...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28636123/sem-imaging-of-the-stimulatory-response-of-raw264-7-cells-against-porphyromonas-gingivalis-using-a-simple-technique-employing-new-conductive-materials
#5
Chisato Takahashi, Yoshiki Umemura, Ayako Naka, Hiromitsu Yamamoto
In the medical biology, it is essential to understand not only biological morphology but also the interaction between biological materials and agents. To study these, electron microscopy (EM) is often utilized. However, sample preparation techniques for EM require a high level of skill and a considerable time. Here, we conducted EM using a simple technique employing a conductive liquid, BEL-1, and compared the results with another simple technique employing an ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4 ])...
June 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28634882/gingipain-of-porphyromonas-gingivalis-manipulates-m1-macrophage-polarization-through-c5a-pathway
#6
Yubo Hou, Haiyan Yu, Xinchan Liu, Gege Li, Jiahui Pan, Changyu Zheng, Weixian Yu
Gingipains secreted by Porphyromonas gingivalis (P. gingivalis, Pg) play an important role in maintaining macrophage infiltrating. And, this study is to evaluate effects of gingipain on M1 macrophage polarization after exposure to Porphyromonas gingivalis (P. gingivalis, Pg) and if these effects are through complement component 5a (C5a) pathway. Mouse RAW264.7 macrophages were exposed to gingipain extracts, Escherichia coli lipopolysaccharides (Ec-LPS), Pg-LPS with or without the C5aR antagonist: PMX-53 for 24 h...
June 20, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28634844/thrombospondin-1-production-regulates-the-inflammatory-cytokine-secretion-in-thp-1-cells-through-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Tian Xing, Yao Wang, Wen-Jie Ding, Yuan-Ling Li, Xiao-Dong Hu, Cong Wang, Ao Ding, Ji-Long Shen
Thrombospondin-1 (TSP-1) is upregulated in several inflammatory diseases. Recent data have shown that macrophages from TSP-1-deficient mice have a reduced inflammatory phenotype, suggesting that TSP-1 plays a part in macrophage activation. DNA microarray approach revealed that Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) may induce the enhanced TSP-1 expression in human monocytes, suggesting a role of TSP-1-mediated pathogenesis in periodontitis. Until recently, the function of TSP-1 has been a matter of debate...
June 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28630069/degradation-of-incretins-and-modulation-of-blood-glucose-levels-by-periodontopathic-bacterial-dipeptidyl-peptidase-4
#8
Yuko Ohara-Nemoto, Manami Nakasato, Yu Shimoyama, Tomomi T Baba, Takeshi Kobayakawa, Toshio Ono, Takashi Yaegashi, Shigenobu Kimura, Takayuki K Nemoto
Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28627377/mikania-glomerata-sprengel-extract-and-its-major-compound-ent-kaurenoic-acid-display-activity-against-bacteria-present-in-endodontic-infections
#9
Dora Lúcia Carrara Moreti, Luís Fernando Leandro, Thaís da Silva Moraes, Monique Rodrigues Moreira, Rodrigo Cassio Sola Veneziani, Sergio Ricardo Ambrosio, Brenda Paula Figueiredo Almeida Gomes, Carlos Henrique Gomes Martins
The search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. Such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. Mikania glomerata (Spreng.), commonly known as "guaco," is a native climbing plant from Brazil that displays a wide range of pharmacological properties. Many of its activities have been attributed to its phytochemical composition, which is mainly composed of diterpenes, such as ent-kaurenoic acid (KA)...
June 13, 2017: Anaerobe
https://www.readbyqxmd.com/read/28623321/dysbiosis-in-chronic-periodontitis-key-microbial-players-and-interactions-with-the-human-host
#10
Zhi-Luo Deng, Szymon P Szafrański, Michael Jarek, Sabin Bhuju, Irene Wagner-Döbler
Periodontitis is an extremely prevalent disease worldwide and is driven by complex dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket microbiota from all domains of life as well as the human host in health and chronic periodontitis. Bacteria showed strong enrichment of 18 KEGG functional modules in chronic periodontitis, including bacterial chemotaxis, flagellar assembly, type III secretion system, type III CRISPR-Cas system, and two component system proteins. Upregulation of these functions was driven by the red-complex pathogens and candidate pathogens, e...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619155/black-pigmented-anaerobic-bacteria-associated-with-ovine-periodontitis
#11
Ana C Borsanelli, Elerson Gaetti-Jardim, Christiane M Schweitzer, Lorenzo Viora, Valentina Busin, Marcello P Riggio, Iveraldo S Dutra
Periodontitis is a polymicrobial infectious disease that causes occlusion change, tooth loss, difficulty in rumination, and premature culling of animals. This study aimed to detect species of the genera Porphyromonas and Prevotella present in the periodontal pocket of sheep with lesions deeper than 5mm (n=14) and in the gingival sulcus of animals considered periodontally healthy (n=20). The presence of microorganisms was evaluated by polymerase chain reaction (PCR) using specific primers for Porphyromonas asaccharolytica, Porphyromonas endodontalis, Porphyromonas gingivalis, Porphyromonas gulae, Prevotella buccae, Prevotella intermedia, Prevotella loescheii, Prevotella melaninogenica, Prevotella nigrescens, Prevotella oralis, and Prevotella tannerae...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28611978/periodontal-pathogens-in-the-etiology-of-pancreatic-cancer
#12
REVIEW
Mesut Öğrendik
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611322/screening-the-antigenic-properties-of-porphyromonas-gingivalis-and-level-of-raised-antibodies-after-antigenic-injection-into-balb-c-mice
#13
Mahdi T Khadematolrasoul, Farin Kiany, Faezeh Saadati
BACKGROUND: Different diagnostic screening tests have been developed to detect periodontal disease in the early stages. Despite these advances still, there is a need for a more practical and beneficial diagnostic test. AIM: The aim of this study was to investigate the possibility of developing such a kit based on the body immune response against Porphyromonas gingivalis. METHOD AND MATERIALS: This experimental study was conducted by culturing P...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28605543/dual-action-of-bacteriocin-plnc8-%C3%AE-%C3%AE-through-inhibition-of-porphyromonas-gingivalis-infection-and-promotion-of-cell-proliferation
#14
Torbjörn Bengtsson, Boxi Zhang, Robert Selegård, Emanuel Wiman, Daniel Aili, Hazem Khalaf
Periodontitis is a chronic inflammatory disease that is characterized by accumulation of pathogenic bacteria, including Porphyromonas gingivalis, in periodontal pockets. The lack of effective treatments has emphasized in an intense search for alternative methods to prevent bacterial colonization and disease progression. Bacteriocins are bacterially produced antimicrobial peptides gaining increased consideration as alternatives to traditional antibiotics. We show rapid permeabilization and aggregation of P. gingivalis by the two-peptide bacteriocin PLNC8 αβ...
June 12, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28604268/mucosal-immunization-with-a-flagellin-adjuvanted-hgp44-vaccine-enhances-protective-immune-responses-in-a-murine-porphyromonas-gingivalis-infection-model
#15
Sao Puth, Seol Hee Hong, Mi Jin Park, Hye Hwa Lee, Youn Suhk Lee, Kwangjoon Jeong, In-Chol Kang, Jeong Tae Koh, Byounggon Moon, Sang Chul Park, Joon Haeng Rhee, Shee Eun Lee
Chronic periodontitis is caused by interactions between the oral polymicrobial community and host factors. Periodontal diseases are associated with dysbiotic shift in oral microbiota. Vaccination against periodontopathic bacteria could be a fundamental therapeutic to modulate polymicrobial biofilms. Because oral cavity is the site of periodontopathic bacterial colonization, mucosal vaccines should provide better protection than vaccines administered systemically. We previously reported that bacterial flagellin is an excellent mucosal adjuvant...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28603700/the-type-ix-secretion-system-t9ss-highlights-and-recent-insights-into-its-structure-and-function
#16
REVIEW
Anna M Lasica, Miroslaw Ksiazek, Mariusz Madej, Jan Potempa
Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secretion system (T9SS), a complex translocon found only in some species of the Bacteroidetes phylum. T9SS plays two roles, depending on the lifestyle of the bacteria. It provides either a means of movement (called gliding motility) for peace-loving environmental bacteria or a weapon for pathogens...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28592970/lps-from-p-gingivalis-negatively-alters-gingival-cell-mitochondrial-bioenergetics
#17
Kiran Napa, Andrea C Baeder, Jeffrey E Witt, Sarah T Rayburn, Madison G Miller, Blake W Dallon, Jonathan L Gibbs, Shalene H Wilcox, Duane R Winden, Jared H Smith, Paul R Reynolds, Benjamin T Bikman
OBJECTIVE: Oral inflammatory pathologies are linked to increased oxidative stress, thereby partly explaining their relevance in the etiology of systemic disorders. The purpose of this work was to determine the degree to which LPS from Porphyromonas gingivalis, the primary pathogen related to oral inflammation, altered gingival mitochondrial function and reactive oxygen species generation. METHODS: Human gingival fibroblast (HGF-1) cells were treated with lipopolysaccharide of P...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28591948/-the-role-of-hmgn2-in-the-development-of-periodontitis-dental-plaque
#18
Yang Luo, Qian Li, Ya-Ping Fan, Jiao Chen, Ping Zhang, Yun Feng
OBJECTIVES: To determine the role of high mobility group chromosomal protein N2 (HMGN2) in the development of periodontitis plaque biofilm. METHODS: Saliva samples were collected before clinical interventions in patients with periodontitis (25 Mild periodontitis, 25 Moderate periodontitis and 25 Severe periodontitis) and healthy controls ( n=25).Following an estimation of dental plaque index, the level of HMGN2 in saliva was determined by enzyme-linked immunosorbent assay (ELISA)...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28590061/porphyromonas-gingivalis-lipopolysaccharide-regulates-ephrin-eph-signalling-in-human-periodontal-ligament-fibroblasts
#19
M Li, C Zhang, L Jin, K Matsuo, Y Yang
OBJECTIVE: EphrinA2-EphA2 and ephrinB2-EphB4 critically engage in bidirectional signalling to modulate alveolar bone remodelling. The present study aimed to investigate the effects of lipopolysaccharides (LPS) derived from Porphyromonas gingivalis on ephrin/Eph signalling in periodontal ligament fibroblasts (PDLFs). MATERIAL AND METHODS: The primary cultured PDLFs were incubated in the absence (as a control) or presence of P. gingivalisLPS at 0.001-10 μg/mL for 24 hours...
June 7, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28589098/manipulation-of-neutrophils-by-porphyromonas-gingivalis-in-the-development-of-periodontitis
#20
REVIEW
Maja Sochalska, Jan Potempa
The pathogenesis of the chronic periodontal disease is associated with a skewed host inflammatory response to periodontal pathogens, such as Porphyromonas gingivalis, that accounts for the majority of periodontal tissue damage. Neutrophils are the most abundant leukocytes in periodontal pockets and depending on the stage of the disease, also plentiful PMNs are present in the inflamed gingival tissue and the gingival crevice. They are the most efficient phagocytes and eliminate pathogens by a variety of means, which are either oxygen-dependent or -independent...
2017: Frontiers in Cellular and Infection Microbiology
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