keyword
MENU ▼
Read by QxMD icon Read
search

P. gingivalis

keyword
https://www.readbyqxmd.com/read/28437177/periodontal-derived-mesenchymal-cell-sheets-promote-periodontal-regeneration-in-inflammatory-microenvironment
#1
Shujuan Guo, Jian Kang, Baohui Ji, Weihua Guo, Yi Ding, Yafei Wu, Weidong Tian
In this study, we investigated the periodontal regenerative potential of dental follicle cell (DFC) sheets and periodontal ligament cell (PDLC) sheets in the simulating inflammatory microenvironment of periodontitis, in order to confirm their regenerative potential for clinical application and explain the possible mechanism. The biological characteristics of DFC sheets and PDLC sheets were explored in lipopolysaccharid from Porphyromonas gingivalis (P. gingivalis LPS) induced inflammation microenvironment in vitro, then cell sheets were transplanted into canine periodontal defects with experimental periodontitis in situ for three months...
February 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28427461/inhibitory-activities-of-selected-sudanese-medicinal-plants-on-porphyromonas-gingivalis-and-matrix-metalloproteinase-9-and-isolation-of-bioactive-compounds-from-combretum-hartmannianum-schweinf-bark
#2
Ebtihal Abdalla M Mohieldin, Ali Mahmoud Muddathir, Tohru Mitsunaga
BACKGROUND: Periodontal diseases are one of the major health problems and among the most important preventable global infectious diseases. Porphyromonas gingivalis is an anaerobic Gram-negative bacterium which has been strongly implicated in the etiology of periodontitis. Additionally, matrix metalloproteinases-9 (MMP-9) is an important factor contributing to periodontal tissue destruction by a variety of mechanisms. The purpose of this study was to evaluate the selected Sudanese medicinal plants against P...
April 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28424689/antimicrobial-and-attractant-roles-for-chemerin-in-the-oral-cavity-during-inflammatory-gum-disease
#3
Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy
Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28415444/formulation-of-thermoreversible-gel-of-cranberry-juice-concentrate-evaluation-biocompatibility-studies-and-its-antimicrobial-activity-against-periodontal-pathogens
#4
Rajeshwari H R, Dinesh Dhamecha, Satveer Jagwani, Dhanashree Patil, Satisha Hegde, Raksha Potdar, Renuka Metgud, Sunil Jalalpure, Subarna Roy, Kiran Jadhav, Neeraj Kumar Tiwari, Sravani Koduru, Shweta Hugar, Suneel Dodamani
The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413322/improved-antimicrobial-effect-of-ginseng-extract-by-heat-transformation
#5
Peng Xue, Yang Yao, Xiu-Shi Yang, Jia Feng, Gui-Xing Ren
BACKGROUND: The incidence of halitosis has a prevalence of 22-50% throughout the world and is generally caused by anaerobic oral microorganisms, such as Fusobacterium nucleatum, Clostridium perfringens, and Porphyromonas gingivalis. Previous investigations on the structure-activity relationships of ginsenosides have led to contrasting results. Particularly, the antibacterial activity of less polar ginsenosides against halitosis-related bacteria has not been reported. METHODS: Crude saponins extracted from the Panax quinquefolius leaf-stem (AGS) were treated at 130°C for 3 h to obtain heat-transformed saponins (HTS)...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28403797/is-the-treatment-with-biological-or-non-biological-dmards-a-modifier-of-periodontal-condition-in-patients-with-rheumatoid-arthritis
#6
Consuelo Romero-Sanchez, Constanza Rodríguez, Pedro Santos, Ana María Mesa, Gloria Inés Lafaurie, Sebastian Giraldo, Juliette De Avila, Diana Marcela Castilla, Michelle Durán, Philippe Chalem, Juan Manuel Bello, Rafael Valle
BACKGROUND AND OBJECTIVE: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity. MATERIALS AND METHODS: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-α and 115 with only DMARDs)...
April 7, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28397552/in-vitro-antimicrobial-activity-of-thymus-vulgaris-essential-oil-against-major-oral-pathogens
#7
Mohammadmehdi Fani, Jamshid Kohanteb
The objective of present investigation was to determine antimicrobial activity of Thymus vulgaris oil on some oral pathogens. Thymus vulgaris oil was prepared by hydrodistillation and tested against 30 clinical isolates of each of Streptococcus pyogenes, Streptococcus mutans, Candida albicans, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans, prepared from related oral infections using agar disk diffusion and broth microdilution methods. Thymus vulgaris oil at concentrations of 16 to 256 μg/mL exhibited strong inhibitory activity on all clinical isolates producing inhibition zones of 7...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28397248/porphyromonas-gingivalis-antibody-levels-and-diagnosis-of-coronary-artery-disease-in-hiv-positive-individuals
#8
V L Berquist, A C Hearps, P Ford, A Jaworowski, S J Leishman, J F Hoy, J M Trevillyan
BACKGROUND AND OBJECTIVE: Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV-positive individuals. MATERIAL AND METHODS: Twenty-four HIV-positive individuals (cases) with stored plasma available in the 12 months before CAD diagnosis were age- and sex-matched 1:2 with 46 HIV-positive individuals without CAD (controls)...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28388583/oral-cancer-cells-sustainedly-infected-with-porphyromonas-gingivalis-exhibit-resistance-to-taxol-and-have-higher-metastatic-potential
#9
Bok Hee Woo, Da Jeong Kim, Jeom Il Choi, Sung Jo Kim, Bong Soo Park, Jae Min Song, Ji Hye Lee, Hae Ryoun Park
Major obstacles to improving the prognosis of patients with oral squamous cell carcinoma (OSCC) are the acquisition of resistance to chemotherapeutic agents and development of metastases. Recently, inflammatory signals are suggested to be one of the most important factors in modulating chemoresistance and establishing metastatic lesions. In addition, epidemiological studies have demonstrated that periodontitis, the most common chronic inflammatory condition of the oral cavity, is closely associated with oral cancer...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387608/common-polymorphisms-in-the-ifi16-and-aim2-genes-are-associated-with-periodontal-disease
#10
Julie T Marchesan, Yizu Jiao, Kevin Moss, Kimon Divaris, William Seaman, Jennifer Webster-Cyriaque, Shaoping Zhang, Ning Yu, Catharine Song, Sompop Bencharit, Ricardo Teles, Steven Offenbacher
BACKGROUND: We investigated the single nucleotide polymorphism (SNP) context of a previously identified periodontitis-associated locus and examined its association with microbial, biological and periodontal disease clinical parameters. METHODS: We annotated a 200Kb-spanning region of 1q12 previously highlighted in a genome-wide association scan among 4,910 European American individuals (SNP rs1633266). Two haplotype blocks were selected. We examined the association of these polymorphisms with data on microbial plaque composition, gingival crevicular fluid (GCF)-interleukin (IL)-1β levels and clinical parameters of periodontal disease...
April 7, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28386896/antimicrobial-activity-of-aqueous-extracts-from-four-plants-on-bacterial-isolates-from-periodontitis-patients
#11
Leila Arbia, Nassima Chikhi-Chorfi, Ilhem Betatache, Chuong Pham-Huy, Selma Zenia, Nabil Mameri, Nadjib Drouiche, Hakim Lounici
Four aqueous extracts of different plant organs are the following: Artemisia herba-alba, Opuntia ficus-indica, Camellia sinensis and Phlomis crinita were evaluated against two bacterial strains: Porphyromonas gingivalis and Prevotella intermedia, which are implicated in periodontal diseases. By using a disc method, these plant extracts demonstrated powerful bacterial activity against these Gram-negative strains. The minimum inhibitory concentration values of the four plant extracts varied between 0.03 and 590...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28384529/vitamin-d-reduces-the-inflammatory-response-by-porphyromonas-gingivalis-infection-by-modulating-human-%C3%AE-defensin-3-in-human-gingival-epithelium-and-periodontal-ligament-cells
#12
Anna De Filippis, Margherita Fiorentino, Luigi Guida, Marco Annunziata, Livia Nastri, Antonietta Rizzo
Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process. Porphyromonas gingivalis, a Gram-negative black-pigmented anaerobe, is a major pathogen in the initiation and progression of periodontitis; it produces several virulence factors that stimulate human gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators. A variety of substances, such as vitamin D, have growth-inhibitory effects on some bacterial pathogens and have shown chemo-preventive and anti-inflammatory activity...
April 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28384159/3lps-binding-protein-and-its-interactions-with-p-gingivalis-lps-modulate-pro-inflammatory-response-and-toll-like-receptor-signaling-in-human-oral-keratinocytes
#13
Pei-Hui Ding, Richard P Darveau, Cun-Yu Wang, Lijian Jin
Lipopolysaccharide (LPS)-binding protein (LBP) as an acute-phase protein plays a crucial role in innate host response to bacterial challenge. Our previous study shows that LBP expression in human gingiva is associated with periodontal status. Porphyromonas gingivalis is a keystone periodontopathogen, and its LPS with lipid A structural heterogeneity critically accounts for periodontal pathogenesis. This study investigated the effects of LBP and its interactions with two featured isoforms of P. gingivalis LPS (tetra-acylated LPS1435/1449 and penta-acylated LPS1690) on the expression of pro-inflammatory cytokines in human oral keratinocytes (HOKs), and the involvement of Toll-like receptor (TLR) signaling...
2017: PloS One
https://www.readbyqxmd.com/read/28383606/generalized-aggressive-periodontitis-microbiological-composition-and-clinical-parameters-in-non-surgical-therapy
#14
María M Usin, Sandra M Tabares, Julieta Menso, Estela R de Albera, Adela Sembaj
The aim of this study was to determine the variations in periodontal parameters and microbiological composition in periodontal pockets at the baseline and 3 and 6 months post treatmentin patients with Generalized Aggressive Periodontitis(GAP) undergoing non surgical periodontal treatment combined with chlorhexidine and systemic antibiotics. Medical and dental history was taken from 10 subjects, average age 30.6±2.7 years, diagnosed with GAP. A non surgical periodontal treatment combined with 0.12% chlorhexidine, 875 mg amoxicillin and 500 mg metronidazole every 12 hours for ten days was conducted...
December 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28382776/behavior-of-two-tannerella-forsythia-strains-and-cell-surface-mutants-in-multispecies-oral-biofilms
#15
Susanne Bloch, Thomas Thurnheer, Yukitaka Murakami, Georgios N Belibasakis, Christina Schäffer
As a member of subgingival multispecies biofilms, Tannerella forsythia is commonly associated with periodontitis. The bacterium has a characteristic cell surface (S-) layer modified with a unique O-glycan. Both the S-layer and the O-glycan were analyzed in this study for their role in biofilm formation by employing an in vitro multispecies biofilm model mimicking the situation in the oral cavity. Different T. forsythia strains and mutants with characterized defects in cell surface composition were incorporated into the model, together with nine species of select oral bacteria...
April 5, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28380669/antibacterial-and-bioactive-coatings-on-titanium-implant-surfaces
#16
Anupama Kulkarni Aranya, Smruti Pushalkar, Minglei Zhao, Racquel Z LeGeros, Yu Zhang, Deepak Saxena
Various surface modifications have been tried for enhancing osseointegration of the dental implants like mechanical and/or chemical treatments and deposition of calcium phosphate coatings. The objective of this research was to develop calcium-phosphate based thin coatings with antibacterial and bioactive properties for potential application in dental implants. Titanium (Ti) discs were immersed in different calcifying solutions: CaP (positive control), F-CaP, Zn-CaP and FZn-CaP and incubated for 24 h. Negative control was uncoated Ti discs...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28373699/oral-administration-of-lactobacillus-gasseri-sbt2055-is-effective-in-preventing-porphyromonas-gingivalis-accelerated-periodontal-disease
#17
R Kobayashi, T Kobayashi, F Sakai, T Hosoya, M Yamamoto, T Kurita-Ochiai
Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28369125/relative-abundance-of-total-subgingival-plaque-specific-bacteria-in-salivary-microbiota-reflects-the-overall-periodontal-condition-in-patients-with-periodontitis
#18
Shinya Kageyama, Toru Takeshita, Mikari Asakawa, Yukie Shibata, Kenji Takeuchi, Wataru Yamanaka, Yoshihisa Yamashita
Increasing attention is being focused on evaluating the salivary microbiota as a promising method for monitoring oral health; however, its bacterial composition greatly differs from that of dental plaque microbiota, which is a dominant etiologic factor of oral diseases. This study evaluated the relative abundance of subgingival plaque-specific bacteria in the salivary microbiota and examined a relationship between the abundance and severity of periodontal condition in patients with periodontitis. Four samples (subgingival and supragingival plaques, saliva, and tongue coating) per each subject were collected from 14 patients with a broad range of severity of periodontitis before periodontal therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28369099/comparative-gene-expression-analysis-of-porphyromonas-gingivalis-atcc-33277-in-planktonic-and-biofilms-states
#19
P Romero-Lastra, M C Sánchez, H Ribeiro-Vidal, A Llama-Palacios, E Figuero, D Herrera, M Sanz
BACKGROUND AND OBJECTIVE: Porphyromonas gingivalis is a keystone pathogen in the onset and progression of periodontitis. Its pathogenicity has been related to its presence and survival within the subgingival biofilm. The aim of the present study was to compare the genome-wide transcription activities of P. gingivalis in biofilm and in planktonic growth, using microarray technology. MATERIAL AND METHODS: P. gingivalis ATCC 33277 was incubated in multi-well culture plates at 37°C for 96 hours under anaerobic conditions using an in vitro static model to develop both the planktonic and biofilm states (the latter over sterile ceramic calcium hydroxyapatite discs)...
2017: PloS One
https://www.readbyqxmd.com/read/28367891/comparison-of-nonsurgical-periodontal-therapy-with-oral-hygiene-instruction-alone-for-chronic-periodontitis
#20
Maaz Asad, Alwani W Abdul Aziz, Renukanth P C Raman, Himratul-Aznita W Harun, Tara Bai T Ali, Karuthan Chinna, Rathna D Vaithilingam
We evaluated changes in clinical variables and microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (≥5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, and Prevotella intermedia...
2017: Journal of Oral Science
keyword
keyword
114494
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"