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P. gingivalis

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https://www.readbyqxmd.com/read/28741270/involvement-of-porphyromonas-gingivalis-in-the-progression-of-non-alcoholic-fatty-liver-disease
#1
Takashi Nakahara, Hideyuki Hyogo, Atsushi Ono, Yuko Nagaoki, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Nobuhiko Hiraga, Clair Nelson Hayes, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Hiromi Abe-Chayama, Hisako Furusho, Tomoaki Shintani, Hidemi Kurihara, Mutsumi Miyauchi, Takashi Takata, Koji Arihiro, Kazuaki Chayama
BACKGROUND AND AIMS: The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. METHODS: (1) Serum IgG antibody titers against P.g fimbriae (fimA) in 200 biopsy-proven NAFLD patients were measured by ELISA and compared with histological findings...
July 24, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28736072/antibacterial-activities-of-natural-lichen-compounds-against-streptococcus-gordonii-and-porphyromonas-gingivalis
#2
Alaa Sweidan, Marylene Chollet-Krugler, Aurelie Sauvager, Pierre van de Weghe, Ali Chokr, Martine Bonnaure-Mallet, Sophie Tomasi, Latifa Bousarghin
The oral bacteria not only infect the mouth and reside there, but also travel through the blood and reach distant body organs. If left untreated, the dental biofilm that can cause destructive inflammation in the oral cavity may result in serious medical complications. In dental biofilm, Streptococcus gordonii, a primary oral colonizer, constitutes the platform on which late pathogenic colonizers like Porphyromonas gingivalis, the causative agent of periodontal diseases, will bind. The aim of this study was to determine the antibacterial activity of eleven natural lichen compounds belonging to different chemical families and spanning from linear into cyclic and aromatic structures to uncover new antibiotics which can fight against the oral bacteria...
July 20, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28725637/opportunistic-pathogen-porphyromonas-gingivalis-modulates-danger-signal-atp-mediated-antibacterial-nox2-pathways-in-primary-epithelial-cells
#3
JoAnn S Roberts, Kalina R Atanasova, Jungnam Lee, Gill Diamond, Jeff Deguzman, Chul Hee Choi, Özlem Yilmaz
Porphyromonas gingivalis, a major opportunistic pathogen in the etiology of chronic periodontitis, successfully survives in human gingival epithelial cells (GECs). P. gingivalis abrogates the effects of a host danger molecule, extracellular ATP (eATP)/P2X7 signaling, such as the generation of reactive oxygen species (ROS) via the mitochondria and NADPH oxidases (NOX) from primary GECs. However, antimicrobial functions of ROS production are thoroughly investigated in myeloid-lineage immune cells and have not been well-understood in epithelial cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28714894/carbonic-anhydrase-from-porphyromonas-gingivalis-as-a-drug-target
#4
REVIEW
Claudiu T Supuran, Clemente Capasso
Periodontitis originates from a microbial synergy causing the development of a mouth microbial imbalance (dysbiosis), consisting of a microbial community composed of anaerobic bacteria. Most studies concerning the treatment of periodontitis have primarily take into account the Gram-negative bacterium Porphyromonas gingivalis, because it is a prominent component of the oral microbiome and a successful colonizer of the oral epithelium. Here, we focus our attention on the study of the carbonic anhydrases (CAs, EC 4...
July 15, 2017: Pathogens
https://www.readbyqxmd.com/read/28714554/type-ix-secretion-the-generation-of-bacterial-cell-surface-coatings-involved-in-virulence-gliding-motility-and-the-degradation-of-complex-biopolymers
#5
Paul D Veith, Michelle D Glew, Dhana G Gorasia, Eric C Reynolds
The Type IX Secretion System (T9SS) is present in over 1000 sequenced species/strains of the Fibrobacteres-Chlorobi-Bacteroidetes superphylum. Proteins secreted by the T9SS have an N-terminal signal peptide for translocation across the inner membrane via the SEC translocon and a C-terminal signal for secretion across the outer membrane via the T9SS. Nineteen protein components of the T9SS have been identified including three, SigP, PorX and PorY that are involved in regulation. The inner membrane proteins PorL and PorM and the outer membrane proteins PorK and PorN interact and a complex comprising PorK and PorN forms a large ring structure of 50 nm in diameter...
July 17, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28713765/prevalence-of-periodontal-pathogens-in-a-group-of-participants-from-the-middle-east-and-north-africa-geographic-region-with-minimal-periodontal-disease
#6
Zoubeida Al Yahfoufi, Wahib Hadchiti
AIM AND OBJECTIVES: To assess the prevalence of the three putative periodontal pathogens such as Aggregatibacter actinomycetemcomitans (A. a), Porphyromonas gingivalis (P. g), and Prevotella intermedia (P. i) in a group of Arab participants from the Middle East and North Africa (MENA) region who had minimal periodontal disease and no history of periodontal treatment and further to analyze the association among these three microorganisms. MATERIALS AND METHODS: Eighty-four participants of varied demographics and oral/dental care habits were screened for this study...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28705771/different-frequencies-of-porphyromonas-gingivalis-infection-in-cancers-of-the-upper-digestive-tract
#7
Xiang Yuan, Yiwen Liu, Jinyu Kong, Bianli Gu, Yijun Qi, Xinshuai Wang, Man Sun, Pan Chen, Wei Sun, Huizhi Wang, Fuyou Zhou, Shegan Gao
The high incidence rate of multiple carcinomas in the upper digestive tract is often explained in terms of involvement of the same underlying risk factors. It has been reported that the oral bacterium Streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. We previously reported occurrence of Porphyromonas gingivalis (P. gingivalis) DNA in esophagus cancer. In this study, the presence of P. gingivalis in specimens of various types of cancer from the upper digestive tract was investigated...
July 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28701797/antimicrobial-effect-of-blue-light-using-porphyromonas-gingivalis-pigment
#8
Ayaka Yoshida, Haruka Sasaki, Toshizo Toyama, Mitsunori Araki, Jun Fujioka, Koichi Tsukiyama, Nobushiro Hamada, Fumihiko Yoshino
The development of antibiotics cannot keep up with the speed of resistance acquired by microorganisms. Recently, the development of antimicrobial photodynamic therapy (aPDT) has been a necessary antimicrobial strategy against antibiotic resistance. Among the wide variety of bacteria found in the oral flora, Porphyromonas gingivalis (P. gingivalis) is one of the etiological agents of periodontal disease. aPDT has been studied for periodontal disease, but has risks of cytotoxicity to normal stained tissue. In this study, we performed aPDT using protoporphyrin IX (PpIX), an intracellular pigment of P...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694291/differential-regulation-of-mas-related-g-protein-coupled-receptor-x2-mediated-mast-cell-degranulation-by-antimicrobial-host-defense-peptides-and-p-gingivalis-lps
#9
Kshitij Gupta, Chizobam Idahosa, Saptarshi Roy, Donguk Lee, Hariharan Subramanian, Anuradha Dhingra, Kathleen Boesze-Battaglia, Jonathan Korostoff, Hydar Ali
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen that contributes to periodontal pathogenesis by disrupting host-microbe homeostasis and promoting dysbiosis. Virulence of P. gingivalis likely reflects an alteration in the lipid A composition of its lipopolysaccharide (LPS) from the penta-acylated (PgLPS1690) to the tetra-acylated (PgLPS1435/1449) form. Mast cells play an important role in periodontitis but the mechanisms of their activation and regulation remain unknown. The expression of epithelium and neutrophil-derived host defense peptides (HDPs; LL-37, human β-defensin-3), which activate mast cells via Mas-related G protein coupled receptor X2 (MRGPRX2), is increased in periodontitis...
July 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28691474/cone-morse-implant-connection-system-significantly-reduces-bacterial-leakage-between-implant-and-abutment-an-in-vitro-study
#10
A Baj, A Bolzoni, A Russillo, D Lauritano, A Palmieri, F Cura, F J Silvestre, A B Giannì
Osseointegrated implants are very popular dental treatments today in the world. In osseointegrated implants, the occlusal forces are transmitted from prosthesis through an abutment to a dental implant. The abutment is connected to the implant by mean of a screw. A screw is the most used mean for connecting an implant to an abutment. Frequently the screws break and are lost. There is an alternative to screw retained abutment systems: the cone-morse connection (CMC). The CMC, thanks to the absence of the abutment screw, guarantees no micro-gaps, no micro-movements, and a reduction of bacterial leakage between implant and abutment...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28691468/bacterial-colonization-of-the-implant-abutment-interface-of-conical-connection-with-an-internal-octagon-an-in-vitro-study-using-real-time-pcr
#11
A Baj, G A Beltramini, A Bolzoni, F Cura, A Palmieri, A Scarano, L Ottria, A B Giannì
Bacterial leakage at the implant-abutment connection of a two-piece implant system is considered the main cause of peri-implantitis. Prevention of bacterial leakage at the implant-abutment connection is mandatory for reducing inflammation process around implant neck and achieving bone stability. Micro-cavities at implant-abutment connection level can favour bacterial leakage, even in modern two-piece implant systems. The conical connection with an internal octagon (CCIO) is considered to be more stable mechanically and allows a more tight link between implant and abutment...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28691467/bidirectional-flux-of-fluids-and-microbiota-at-implant-abutment-connection-of-fmd-storm-implant-system-an-in-vitro-stud-y-using-rt-pcr
#12
A Baj, M Romano, E Segna, A Palmieri, F Cura, A Scarano, L Ottria, A B Giannì
The purpose of the present microbiological study was to evaluate bacterial leakage at implant-abutment connection level of a new type of implant (Storm implant (FMD, Falappa Medical Devices®, Rome, Italy) using Real-Time Polymerase Chain Reaction (RT-PCR). This implant presents a polygonal external implantabutment connection with a geometry that provides a hex on which engage complementary abutments. To identify the capability of the implant to protect the internal space from the external environment, the passage of genetically modified Escherichia coli across implant-abutment interface was evaluated...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28689365/compromised-inflammatory-cytokine-response-to-p-gingivalis-lps-by-fibroblasts-from-inflamed-human-gingiva
#13
Tracy R Fitzsimmons, Shaohua Ge, P Mark Bartold
OBJECTIVES: The aims of this study were to compare the in vitro cytokine response of gingival fibroblasts (GF's) from healthy and inflamed human gingival tissues and to assess whether GF's from inflamed gingivae are capable of mounting a secondary inflammatory response after exposure to P. gingivalis LPS. MATERIALS AND METHODS: GF's were obtained from healthy donors and periodontitis patients and cultured in vitro. Cells were exposed to P. gingivalis LPS for 24h before measurement of MCP-1, GRO, IL-6, IL-8 and VEGF using a bead-based multiplex assay...
July 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28682554/-effects-of-cytosolic-bacteria-on-cyclic-gmp-amp-synthase-expression-in-human-gingival-tissues-and-periodontal-ligament-cells
#14
Yang Xiaojun, Tan Yongmei, Tian Zhihui, Zhou Ting, Zhao Wanghong, Hou Jin
OBJECTIVE: This work aims to determine the effect of cytosolic bacteria on the expression of cyclic GMP-AMP synthase (cGAS) in human periodontal ligament cells (hPDLCs) and gingival tissues. METHODS: The ability of Porphyromonas gingivalis (P. gingivalis) to invade hPDLCs was detected using laser scanning confocal microscope assay at a multiplicity of infection of 10. P. gingivalis-infected cells were sorted by fluorescence-activated cell sorting (FACS). Then, quantitative real time reverse transcription polymerase chain reaction (qRT-PCR) and Western blot were used to detect cGAS expression in infected cells...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28682552/-effects-of-oral-interventions-on-carotid-artery-in-rats-with-chronic-periodontitis-for-the-detection-of-porphyromonas-gingivalis-and-the-expression-of-c-reactive-protein
#15
Ren Xiuyun, Wang Chong, Liu Xin, Li Hao, Ma Qianhui, Lin Mu, Shi Xuexue, Gao Jinhua
OBJECTIVE: This study aimed to establish a SD rat model of chronic periodontitis (CP) merged with hyperlipidemia (HL), perform periodontal treatment, detect the expression of partial C-reactive protein (CRP) and Porphyromonas gingivalis (P. gingivalis) in the rat carotid artery, and explore the relationship between periodontitis and atherosclerosis. METHODS: SD rats were randomly divided into three groups: control group (A), HL group (B), and CP+HL group (C). Group C rats were divided into natural process group (C1), scaling and root planning group (C2), and tooth extraction group (C3)...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28682542/-effects-of-paeonol-on-the-function-of-bone-marrow-derived-macrophage-from-porphyromonas-gingivalis-induced-mice
#16
Chen Zhu, Su Lingkai
OBJECTIVE: This work aims to examine the effects of paeonol treatment on the ability of bone marrow-derived macrophage (BMM) to excrete inflammatory factors and to differentiate into osteoclasts upon induction with Porphyromonas gingivalis (P. gingivalis). This work also aims to investigate the underlying mechanisms of these abilities. METHODS: BMM culture was treated with different paeonol concentrations at for 1 h and then stimulated with P. gingivalis for 24 h before programmed death-ligand 1 (PD-L1) was quantified with flow cytometry...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28681377/chronic-periodontitis-is-associated-with-platelet-factor-4-pf4-secretion-a-pilot-study
#17
Mathieu Brousseau-Nault, Jayachandran N Kizhakkedathu, Hugh Kim
AIM: Platelets contribute to chronic inflammation but their role in periodontitis is not well understood. The aim of this study was to compare platelet recruitment and activation in healthy and inflamed periodontium. MATERIALS AND METHODS: Gingival crevicular fluid (GCF) samples were obtained from sites of healthy periodontium, gingivitis and periodontitis. Platelets were quantified in the GCF by staining and microscopy. GCF concentrations of platelet factor 4 (PF4) [PF4]GCF and glycoprotein IIbIIIa ([GPIIbIIIa]GCF ) were determined by ELISA...
July 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28674708/the-association-of-periodontopathic-bacteria-levels-%C3%A2-in-saliva-and-tongue-coating-with-oral-malodor-in-periodontitis-patients
#18
Hironobu Takeuchi, Miho Machigashira, Naoshi Takeuchi, Toshiaki Nakamura, Kazuyuki Noguchi
PURPOSE: To elucidate the association oral malodor with the levels of periodontopathic bacteria in saliva and tongue coating of periodontitis patients with oral malodor. MATERIALS AND METHODS: In 25 periodontitis patients, the organoleptic test (OLT) was performed, the levels of volatile sulfur compounds (VSCs) were measured, tongue coating (TC) score was determined, and periodontal parameters and the proportions of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia and Prevotella intermedia in the saliva and the tongue coating were evaluated...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28674705/antibacterial-effects-of-toothpastes-evaluated-in-an-%C3%A2-in-vitro-biofilm-model
#19
Eva Fernández, María Del Carmen Sánchez, Arancha Llama-Palacios, Mariano Sanz, David Herrera
PURPOSE: To test the antibacterial effects of different toothpastes with the slurry method of toothpaste application in an in vitro oral biofilm model including relevant periodontal pathogens. MATERIALS AND METHODS: Four commercially available toothpastes, two containing sodium fluoride (NaF) at different concentrations (1450 and 2500 ppm), two NaF with either triclosan or stannous fluoride, and a control phosphate-buffered saline (PBS) were used. Multispecies biofilms containing 6 species of oral bacteria were grown on hydroxyapatite disks for 72 h and then exposed for 2 min to the toothpaste slurries or phosphate buffer saline (PBS) by immersion, under continuous agitation at 37°C...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28671508/investigation-of-a-novel-predictive-biomarker-profile-for-the-outcome-of-periodontal-treatment
#20
Sarhang S Gul, Gareth S Griffiths, Graham P Stafford, Mohammed I Al-Zubidi, Andrew Rawlinson, Charles W I Douglas
BACKGROUND: An ability to predict the response to conventional non-surgical treatment of a periodontal site would be advantageous. However, so far the biomarkers or tests devised to achieve this have lacked sensitivity. The aim of this study was to assess the ability of a novel combination of biomarkers to predict the outcome of treatment of patients with chronic periodontitis. METHODS: GCF and subgingival plaque were collected from 77 patients at 3 representative sites, 1 healthy (≤ 3mm) and 2 diseased (≥ 6mm) at baseline and at 3 and 6-months post treatment...
July 3, 2017: Journal of Periodontology
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