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https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#1
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28324781/genesis-and-properties-of-wetland-soils-by-vis-nir-swir-as-a-technique-for-environmental-monitoring
#2
José Alexandre Melo Demattê, Ingrid Horák-Terra, Raphael Moreira Beirigo, Fabrício da Silva Terra, Karina Patrícia Prazeres Marques, Caio Troula Fongaro, Alexandre Christófaro Silva, Pablo Vidal-Torrado
Wetlands are important ecosystems characterized by redoximorphic environments producing typical soil forming processes and organic carbon accumulation. Assessments and management of these areas are dependent on knowledge about soil characteristics and variability. By reflectance spectroscopy, information about soils can be obtained since their spectral behaviors are directly related to their chemical, physical, and mineralogical properties reflecting the pedogenetic processes and environment conditions. Our aims were: (a) to characterize the main soil classes of wetlands regarding their spectral behaviors in VIS-NIR-SWIR (350-2500 nm) and relate them to pedogenesis and environmental conditions, (b) to determine spectral ranges (bands) with greater expression of the main soil properties, (c) to identify spectral variations and similarities between hydromorphic soils from wetlands and other soils under different moisture conditions, and (d) to propose spectral models to quantify some chemical and physical soil properties used as environmental quality indicators...
March 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28324168/the-effect-of-eccentric-exercise-with-blood-flow-restriction-on-neuromuscular-activation-microvascular-oxygenation-and-the-repeated-bout-effect
#3
Jakob D Lauver, Trent E Cayot, Timothy Rotarius, Barry W Scheuermann
PURPOSE: To examine the effect of low-intensity eccentric contractions with and without blood flow restriction (BFR) on microvascular oxygenation, neuromuscular activation, and the repeated bout effect (RBE). METHODS: Participants were randomly assigned to either low-intensity (LI), low-intensity with BFR (LI-BFR), or a control (CON) group. Participants in LI and LI-BFR performed a preconditioning bout of low-intensity eccentric exercise prior to about of maximal eccentric exercise...
March 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28319939/radical-scavenging-activity-of-a-sunscreen-enriched-by-antioxidants-providing-protection-in-the-whole-solar-spectral-range
#4
Carla Souza, Patrícia Maia Campos, Sabine Schanzer, Stephanie Albrecht, Silke B Lohan, Jürgen Lademann, Maxim E Darvin, Martina C Meinke
BACKGROUND/AIM: The main reason for extrinsic skin aging is the negative action of free radicals. The formation of free radicals in the skin has been associated with ultraviolet (UV) exposure and also to visible (VIS) and near-infrared (NIR) irradiations. The aim of the present study was to evaluate the efficacy of a sunscreen in the whole solar range. METHODS: The radical-scavenging activity of a sunscreen in the UV, VIS, and NIR ranges was evaluated using electron paramagnetic resonance spectroscopy...
March 21, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28319483/advances-in-cardiac-transplantation
#5
Stavros G Drakos, Nir Uriel
No abstract text is available yet for this article.
March 17, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28318608/multi-center-evaluation-of-one-commercial-and-12-in-house-real-time-pcr-assays-for-detection-of-mycoplasma-pneumoniae
#6
Roger Dumke, Alvaro J Benitez, Victoria Chalker, Karolina Gullsby, Birgit Henrich, Carlos Hidalgo-Grass, Theo Hoogenboezem, Darja Kese, Katherine Loens, Jolanda Maaskant, Ayelet Michael-Gayego, Allon E Moses, Ran Nir-Paz, Suzan D Pas, Sabine Pereyre, Randi F Petersen, Meike Rosenblatt, Annemarie M C van Rossum, Søren A Uldum, Wendy W J Unger, Dominique Ursi, Jonas M Winchell, Cecile Bebear
Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches. Despite differences on threshold values of samples, all assays were able to detect at least 20M. pneumoniae genomes per reaction.
March 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28318065/ultra-narrow-low-bandgap-graphene-nanoribbons-from-bromoperylenes-synthesis-and-terahertz-spectroscopy
#7
Daniel Jänsch, Ivan Ivanov, Yulian Zagranyarski, Ivana Duznovic, Martin Baumgarten, Dimitry Turchinovich, Chen Li, Mischa Bonn, Klaus Müllen
Soluble ultra-narrow armchair graphene nanoribbons (AGNRs) with length of ≈20 nm and completely fused cores exceeding 5 nm in length, pronounced near-infrared (NIR) absorption up to 1400 nm, and a low band gap (≈0.9 eV) are synthesized from 3,9(3,10)-dibromoperylene and 3,4,9,10-tetrabromoperylene. Since the monomers are obtained from perylene carboxyanhydrides, a remarkable link between dye and graphene chemistry is established. The two-step protocol for the AGNR synthesis by aryl-aryl coupling and subsequent cyclodehydrogenation is compared with a direct Yamamoto polymerization...
March 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28317371/high-performance-near-infrared-luminescent-solar-concentrators
#8
Raquel Rondão, Ana Frias, Sandra Correia, Lianshe Fu, Verónica de Zea Bermudez, Paulo André, Rute A S Ferreira, Luis D Carlos
Luminescent solar concentrators (LSCs) appear as candidates to enhance the performance of photovoltaic (PV) cells and contribute to reduce the size of PV systems, decreasing, therefore, the amount of material needed, and thus the cost associated with energy conversion. One way to maximize the devices performance is to explore near infrared (NIR)-emitting centers, resonant with the maximum optical response of the most common Si-based PV cells. Nevertheless, very few examples in the literature demonstrate the feasibility of fabricating LSCs emitting in the NIR region...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28316242/wafer-scale-synthesis-of-high-quality-semiconducting-two-dimensional-layered-inse-with-broadband-photoresponse
#9
Zhibin Yang, Wenjing Jie, Chun-Hin Mak, Shenghuang Lin, Huihong Lin, Xianfeng Yang, Feng Yan, Shu Ping Lau, Jianhua Hao
Large-scale synthesis of two-dimensional (2D) materials is one of the significant issues for fabricating layered materials into practical devices. As one of the typical III-VI semiconductors, InSe has attracted much attention due to its outstanding electrical transport property, attractive quantum physics characteristics and dramatic photoresponse when it is reduced to atomic scale. However, scalable synthesis of single phase 2D InSe has not yet been achieved so far, greatly hindering further fundamental studies and device applications...
March 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28315815/self-assembled-photoadditives-in-polyester-films-allow-stop-and-go-chemical-release
#10
Ting Cheng, Richard O'Rorke, Raphael Francois Ortiz, Tay Yee Yan, Eva Hemmer, Fiorenzo Vetrone, Robert S Marks, Terry W J Steele
Near-infrared (NIR) triggered chemical delivery allows on-demand release with the advantage of external tissue stimulation. Bioresorbable polyester poly-L-lactic acid (PLLA) was compounded with photoadditives of neat zinc oxide (ZnO) nanoparticles and 980 → 365 nm LiYF4:Tm(3+), Yb(3+) upconverting nanoparticles (UCNP). Subsequently, neat ZnO and UCNP blended PLLA films of sub-50 μm thickness were knife casted with a hydrophobic small molecule drug mimic, fluorescein diacetate. The PLLA films displayed a 500 times increase in fluorescein diacetate release from the 50 mW NIR irradiated PLLA/photoadditive film compared to non-irradiated PLLA control films...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28315738/pulmonary-sarcomatoid-carcinomas-commonly-harbor-either-potentially-targetable-genomic-alterations-or-high-tumor-mutational-burden-as-observed-by-comprehensive-genomic-profiling
#11
Alexa B Schrock, Shuyu D Li, Garrett M Frampton, James Suh, Eduardo Braun, Ranee Mehra, Steven Buck, Jose A Bufill, Nir Peled, Nagla Abdel Karim, Cynthia Hsieh, Manuel Doria, James Knost, Rong Chen, Sai-Hong Ignatius Ou, Jeffrey S Ross, Philip J Stephens, Paul Fishkin, Vincent A Miller, Siraj M Ali, Balazs Halmos, Jane J Liu
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a high-grade non-small cell lung carcinoma (NSCLC) characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered due to limited and inconsistent molecular characterization. METHODS: Hybrid-capture based comprehensive genomic profiling (CGP) was performed on DNA from 15,867 FFPE NSCLCs including 125 PSCs (0.8%). Tumor mutational burden (TMB) was calculated from 1...
March 15, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28314203/near-infrared-nir-disrelation-mapping-analysis-for-poly-lactic-acid-nanocomposite
#12
Hideyuki Shinzawa, Junji Mizukado
Near infrared (NIR) imaging data of poly(lactic) acid (PLA) nanocomposite were analysed by disrelation mapping to prove the possible interaction between PLA matrix and montmorillonite-based nanoclay. The basic concept of disrelation mapping can be viewed as a spatial filter based on two-dimensional (2D) correlation function to elucidate specific areas where disrelated variation between intensities occurs. Correlation intensity develops on disrelation map only if spectral intensities at v1 and v2 within the local spatial area vary in a dissimilar manner...
March 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#13
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28304158/near-infrared-light-responsive-semiconductor-polymer-composite-hydrogels-toward-spatial-temporal-controlled-release-via-photothermal-sponge-effect
#14
Yingjie Wu, Kai Wang, Shuo Huang, Cangjie Yang, Mingfeng Wang
Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications such as remotely controlled release, but the NIR agents previously used have been largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR photothermal responsive hydrogels, which could undergo structural changes in response to NIR light for biomedical applications in drug delivery and controlled release. The hydrogels synthesized by integrating a narrow bandgap semiconductor polymer poly(diketopyrrolopyrrole-alt-3,4-ethylenedioxythiophene) (PDPPEDOT) with polymerization of N-isopropylacrylamide (NIPAM) show rapid and reversible mechanical shrinkage upon NIR light irradiation and can serve as carriers for anticancer drug loading and spatial/temporal control of drug release...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28303659/invasive-characterization-of-atherosclerotic-plaque-in-patients-with-peripheral-arterial-disease-using-near-infrared-spectroscopy-intravascular-ultrasound
#15
Amr E Abbas, Sibin K Zacharias, James A Goldstein, Ivan D Hanson, Robert D Safian
OBJECTIVES: We describe the characteristics of atherosclerotic plaque in patients with peripheral arterial disease (PAD) using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) BACKGROUND: Imaging and autopsy studies have described atherosclerotic plaque in different vascular beds, including varying degrees of lipid, fibrosis, and calcification. Recently, NIRS has been validated as an accurate method for detecting lipid-core plaque (LCP) in the coronary circulation. Invasive evaluation of plaque composition using NIRS-IVUS has not been reported in different peripheral arterial circulations...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28300477/evaluation-of-intracameral-pentablock-copolymer-thermosensitive-gel-for-sustained-drug-delivery-to-the-anterior-chamber-of-the-eye
#16
Elizabeth Schaefer, Sara M Smith, Jacklyn Salmon, Santhi Abbaraju, Rasidul Amin, Sidney Weiss, Ulrich Grau, Poonam Velagaleti, Brian Gilger
PURPOSE: To investigate PTSgels (Pentablock copolymers) as an injectable formulation technology for sustained ocular drug delivery. Drug release profile, tolerability, and polymer degradation for one of the thermosensitive, biodegradable, and biocompatible compositions were investigated through intracameral (IC) injection in rabbits. METHODS: New Zealand White rabbit eyes were injected IC (50 μL) with 100 μg near-infrared-immunoglobulin G (NIR-IgG) in balanced salt solution (BSS) or 20% PTSgel; or with PTSgel or BSS alone...
March 16, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28300393/remote-control-and-modulation-of-cellular-events-by-plasmonic-gold-nanoparticles-implications-and-opportunities-for-biomedical-applications
#17
Jiayang Li, Jing Liu, Chunying Chen
Compared to traditional hyperthermia methods, gold nanoparticles (Au NPs) successfully achieve site-specific incremental temperature in deep tissues. By virtue of near-infrared (NIR) laser-mediated photothermal treatment, Au NPs have been widely explored in clinical and preclinical applications, including cancer therapy and tissue engineering. In this issue of ACS Nano, Suzuki, Ciofani, and colleagues demonstrate how gold nanoshells can remotely activate striated muscle cells via inducing myotube contraction and modulating related gene expression by mild heat stimulation under NIR irradiation...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28300342/a-stable-soluble-and-crystalline-supramolecular-system-with-a-triplet-ground-state
#18
Tsukasa Futagoishi, Tomoko Aharen, Tatsuhisa Kato, Azusa Kato, Toshiyuki Ihara, Tomofumi Tada, Michihisa Murata, Atsushi Wakamiya, Hiroshi Kageyama, Yoshihiko Kanemitsu, Yasujiro Murata
A supramolecular complex was constructed by encapsulation of a (3) O2 molecule inside an open-cage C60 derivative. Its single-crystal X-ray diffraction analysis revealed the presence of the (3) O2 at the center of the fullerene cage. The CV measurements suggested that unprecedented dehydrogenation was promoted by the encapsulated (3) O2 after two-electron reduction. The ESR measurements displayed the triplet character as well as the anisotropy of the (3) O2 . Additionally, the SQUID measurements also demonstrated the paramagnetic behavior above 3 K without an antiferromagnetic transition...
March 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28300268/rgo-aunr-ha-5fu-nanocomposite-with-multi-stage-release-behavior-and-efficient-antitumor-activity-for-synergistic-therapy
#19
Ying Yang, Yunlong Wang, Manzhou Zhu, Yan Chen, Yazhong Xiao, Yuhua Shen, Anjian Xie
A reduced graphene oxide (RGO)/gold nanorod (AuNR)/hydroxyapatite (HA) nanocomposite was designed and successfully synthesized for the first time. An anticancer drug, 5-fluorouracil (5FU), was chosen as a model drug to be loaded in RGO/AuNR/HA. The fabricated RGO/AuNR/HA-5FU showed robust, selective targeting and penetrating efficiency against HeLa cells due to the good compatibility and nontoxicity of HA, and showed excellent synergetic antitumor effects through combined chemotherapy (CT) by 5FU and photothermal therapy (PTT) by both RGO and AuNRs under near-infrared (NIR) laser irradiation...
March 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28299923/amphiphilic-semiconducting-oligomer-for-near-infrared-photoacoustic-and-fluorescence-imaging
#20
Chao Yin, Xu Zhen, Hui Zhao, Yufu Tang, Yu Ji, Yan Lyu, Quli Fan, Wei Huang, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have emerged as an alternative class of optical nanoagents for imaging applications. However, the general preparation method for SPNs is nanoprecipitation, which is likely to encounter the issue of nanoparticle dissociation. We herein report non-dissociable near-infrared (NIR)-absorbing organic semiconducting nanoparticles for in vivo photoacoustic (PA) and fluorescence imaging. The nanoparticles are self-assembled from an amphiphilic semiconducting oligomer (ASO) that has a hydrophobic semiconducting oligomer backbone attached by hydrophilic poly(ethylene glycol) (PEG) side chains...
March 16, 2017: ACS Applied Materials & Interfaces
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