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https://www.readbyqxmd.com/read/29161470/resequencing-of-a-mutant-bearing-an-iron-starvation-recovery-phenotype-defines-slr1658-as-a-new-player-in-the-regulatory-network-of-a-model-cyanobacterium
#1
Hagit Zer, Ketty Margulis, Jens Georg, Yoram Shotland, Gergana Kostova, Laure Sultan, Wolfgang R Hess, Nir Keren
Photosynthetic microorganisms encounter an erratic nutrient environment characterized by periods of iron limitation and sufficiency. Surviving in such an environment requires mechanisms for handling these transitions. Our study identified a regulatory system involved in the process of recovery from iron limitation in cyanobacteria. We set out to study the role of bacterioferritin co-migratory proteins during transitions in iron bioavailability in the cyanobacterium Synechocystis sp. PCC 6803 using knockout strains coupled with physiological and biochemical measurements...
November 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29161235/influence-of-ductus-arteriosus-on-peripheral-muscle-oxygenation-and-perfusion-in-neonates
#2
Lukas Peter Mileder, Tessa Mueller, Nariae Baik-Schneditz, Jasmin Pansy, Bernhard Schwaberger, Corinna Binder-Heschl, Berndt Urlesberger, Gerhard Pichler
In neonates, a patent ductus arteriosus (DA) may be associated with severe complications. We used near-infrared spectroscopy (NIRS) with venous occlusion to investigate the influence of an open DA on peripheral muscle oxygenation/perfusion in preterm neonates. Approach: We analyzed secondary outcome parameters collected as part of prospective observational studies. NIRS measurements were performed between the first and third day of life. Arterial oxygen saturation (SaO2) and heart rate (HR) were monitored by pulse oximetry on the ipsilateral foot...
November 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29160700/tailoring-panchromatic-absorption-and-excited-state-dynamics-of-tetrapyrrole-chromophore-bodipy-rylene-arrays-interplay-of-orbital-mixing-and-configuration-interaction
#3
Amit Kumar Mandal, James R Diers, Dariusz M Niedzwiedzki, Gongfang Hu, Rui Liu, Eric J Alexy, Jonathan S Lindsey, David F Bocian, Dewey Holten
Three sets of tetrapyrrole-chromophore arrays have been examined that exhibit panchromatic absorption across large portions of the near-ultraviolet (NUV) to near-infrared (NIR) spectrum along with favorable excited-state properties for use in solar-energy conversion. The arrays vary the tetrapyrrole (porphyrin, chlorin, bacteriochlorin), chromophore (boron-dipyrrin, perylene, terrylene), and attachment sites (meso-position, β-pyrrole position). In all, seven dyads, one triad, and nine benchmarks in toluene and benzonitrile were studied using steady-state and time-resolved absorption and fluorescence spectroscopy...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29160225/phosphatidylserine-targeted-single-walled-carbon-nanotubes-for-photothermal-ablation-of-bladder-cancer
#4
Needa A Virani, Carole Davis, Patrick McKernan, Paul Hauser, Robert E Hurst, Joel Slaton, Ricardo P Silvy, Daniel E Resasco, Roger G Harrison
Bladder cancer has a 60-70% recurrence rate most likely due to residual tumour left behind after a transurethral resection (TUR). Failure to completely resect the cancer can lead to recurrence and progression into higher grade tumours with metastatic potential. We present here a novel therapy to treat superficial tumours with the potential to decrease recurrence. The therapy is a heat-based approach in which bladder tumour specific single-walled carbon nanotubes (SWCNTs) are delivered intravesically at a very low dose (0...
November 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29160012/near-infrared-spectroscopy-might-be-a-useful-tool-for-predicting-the-risk-of-vascular-complications-after-pediatric-liver-transplants-two-case-reports
#5
Juntaro Shiba, Masaaki Satoh, Koki Taira, Yasunori Niwa, Soichiro Inoue, Koichi Mizuta, Mamoru Takeuchi
In patients that have undergone liver transplants, a postoperative reduction in the blood flow of the liver graft represents a critical complication. We recently encountered an interesting phenomenon; that is, we found that the rSO2 level of the liver graft, as measured by NIRS, drops in patients that subsequently require an emergency liver biopsy. An 8-month-old female and an 8-month-old male underwent living donor liver transplants for biliary atresia. In both cases, a reduction in rSO2 was detected before an emergency liver biopsy was required...
November 21, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29159501/a-fundamental-study-of-photoluminescence-modulation-from-dna-wrapped-single-walled-carbon-nanotubes
#6
Shusuke Oura, Masahiro Ito, Yoshikazu Homma, Kazuo Umemura
In this study, we investigated the interaction of base sequence-assigned single-stranded DNA (ssDNA) molecules with the surfaces of single-walled carbon nanotube (SWNT)-thymine (T30)/cytosine (C30) hybrids (T30/C30-SWNT), by measuring the modulation of near-infrared (NIR) photoluminescence (PL). Significant PL shifts were observed when T30/C30-SWNTs were reacted with 30-mers of adenine (A30)/guanine (G30). In contrast, when non-complementary ssDNA was used, no significant energy shift was observed in the PL modulation except when T30-SWNTs were reacted with G30...
November 20, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29159358/optical-manipulation-of-individual-strongly-absorbing-platinum-nanoparticles
#7
Akbar Samadi, Poul Martin Bendix, Lene B Oddershede
Nanostructures with exceptional absorption in the near infrared (NIR) regime are receiving significant attention due to their ability to promote controlled local heating in biological material upon irradiation. Also, such nano-structures have numerous applications in nano-electronics and for bio-exploration. Therefore, significant effort is being put into controlling and understanding plasmonic nanostructures. However, essentially all focus has been on NIR resonant gold nanoparticles and remarkably little attention has been given to nanoparticles of other materials that may have superior properties...
November 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29159192/sex-differences-in-lrrk2-g2019s-and-idiopathic-parkinson-s-disease
#8
Marta San Luciano, Cuiling Wang, Roberto A Ortega, Nir Giladi, Karen Marder, Susan Bressman, Rachel Saunders-Pullman
Objective: To evaluate sex differences and the relative effect of G2019S LRRK2 mutations in Parkinson's disease (PD). Methods: 530 LRRK2 PD carriers and 759 noncarrier PD (idiopathic, IPD) evaluated as part of the Fox Foundation (MJFF) Consortium were included. All participants completed a study visit including information on clinical features, treatment, examination, and motor and nonmotor questionnaires. Clinical features were compared between men and women separately for IPD and LRRK2 PD; and features were compared between IPD and LRRK2 PD separately for men and women...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29158848/biodegradable-core-shell-dual-metal-organic-frameworks-nanotheranostic-agent-for-multiple-imaging-guided-combination-cancer-therapy
#9
Dongdong Wang, Jiajia Zhou, Ruohong Shi, Huihui Wu, Ruhui Chen, Beichen Duan, Guoliang Xia, Pengping Xu, Hui Wang, Shu Zhou, Chengming Wang, Haibao Wang, Zhen Guo, Qianwang Chen
Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach...
2017: Theranostics
https://www.readbyqxmd.com/read/29158837/temperature-sensitive-gold-nanoparticle-coated-pluronic-pll-nanoparticles-for-drug-delivery-and-chemo-photothermal-therapy
#10
Ying Sun, Qi Wang, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan
Gold nanoparticle-coated Pluronic-b-poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, in which Pluronic-PLL acts as the reductant for the formation of AuNPs without the need for an additional reducing agent. METHODS: The deposition of AuNPs on the surface of Pluronic-PLL micelles and the thermal response of the system were followed via ultraviolet-visible spectroscopy and dynamic light scattering...
2017: Theranostics
https://www.readbyqxmd.com/read/29158821/ultra-small-ph-responsive-nd-doped-nadyf4-nanoagents-for-enhanced-cancer-theranostic-by-in-situ-aggregation
#11
Yuxin Liu, Huimin Fan, Quanwei Guo, Anqi Jiang, Xiaoxia Du, Jing Zhou
To achieve accurate tumor location and highly efficient cancer therapy effect, the properties of cancer theranostic agents should be optimized and enhanced. In this work, ultra-small Nd doped NaDyF4 were firstly reported as novel contrast agents for near-infrared second window downconversion luminescence (NIR II DCL) and magnetic resonance imaging. Based on the optimization strategy, gallic acid-Fe(III) complex modified NaDyF4:10%Nd (NaDyF4:10%Nd-GA-Fe) was selected as the optimal agent with high transversal relaxivity, strong NIR II DCL, high photothermal conversion efficiency, and low toxicity...
2017: Theranostics
https://www.readbyqxmd.com/read/29157790/improving-the-neurological-prognosis-following-ohca-using-real-time-evaluation-of-cerebral-tissue-oxygenation-a-case-report
#12
Yasuaki Koyama, Yoshiaki Inoue, Shuhei Hisago, Aiki Marushima, Keiichi Hagiya, Yuichiro Yamasaki, Yuki Enomoto, Nobutake Shimojo, Satoru Kawano, Taro Mizutani
BACKGROUND: The neurological prognosis is poor for patients suffering from out-of-hospital cardiac arrest (OHCA), in the absence of bystander cardio pulmonary resuscitation (CPR), and showing asystole as the initial waveform. However, such patients have the potential of resuming social activity if cerebral tissue oxygen saturation can be preserved. CASE PRESENTATION: We recently encountered a 60-year-old man who had suffered an OHCA in the absence of bystander CPR, and who successfully resumed complete social activity despite initial asystole and requiring at least 75min of chest compressions before return of spontaneous circulation (ROSC)...
November 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29157051/cerebral-nirs-patterns-in-late-preterm-and-very-preterm-infants-becoming-late-preterm
#13
Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo
BACKGROUND: Near Infrared Spectroscopy (NIRS) has been proposed as a useful, noninvasive monitoring technique providing reliable information about central nervous system (CNS) oximetry and function. Recently, brain damage has been reconsidered as a dynamic process evolving over the weeks of gestation. We therefore investigated NIRS cerebral pattern differences between healthy late preterm infants (LPTo) and very preterm infants becoming late preterm (LPT). METHODS: We conducted an observational study in 40 healthy late preterm infants, matched for gestational age at monitoring, of whom 20 where LPTo and 20 LPT...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29156817/near-infrared-photothermal-therapy-using-anti-egfr-gold-nanorod-conjugates-for-triple-negative-breast-cancer
#14
Meihua Zhang, Hoe Suk Kim, Tiefeng Jin, Jisu Woo, Yin Ji Piao, Woo Kyung Moon
Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156774/micrornas-as-predictors-for-cns-relapse-of-systemic-diffuse-large-b-cell-lymphoma
#15
Nir Pillar, Osnat Bairey, Neta Goldschmidt, Yakov Fellig, Yevgenia Rosenblat, Itchak Shehtman, Danielle Haguel, Pia Raanani, Noam Shomron, Tali Siegal
Systemic diffuse large B-cell lymphoma (DLBCL) is a potentially curable disease using current regimen of immunochemotherapy. Central nervous system (CNS) relapse is a complication that occurs in approximately 5% of DLBCL patients and is associated with a high fatality rate. Early identification of molecular markers for CNS involvement may serve for the highly needed accurate stratification of patients into risk groups regarding CNS relapse. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and are known to be involved in DLBCL pathophysiology...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155787/synthesis-of-core-shell-lanthanide-doped-upconversion-nanocrystals-for-cellular-applications
#16
Xiangzhao Ai, Linna Lyu, Jing Mu, Ming Hu, Zhimin Wang, Bengang Xing
Lanthanide-doped upconversion nanocrystals (UCNs) have attracted much attention in recent years based on their promising and controllable optical properties, which allow for the absorption of near-infrared (NIR) light and can subsequently convert it into multiplexed emissions that span over a broad range of regions from the UV to the visible to the NIR. This article presents detailed experimental procedures for high-temperature co-precipitation synthesis of core-shell UCNs that incorporate different lanthanide ions into nanocrystals for efficiently converting deep-tissue penetrable NIR excitation (808 nm) into a strong blue emission at 480 nm...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155569/redox-behavior-of-a-dinuclear-ruthenium-ii-complex-bearing-an-uncommon-bridging-ligand-insights-from-high-pressure-electrochemistry
#17
Maximilian Dürr, Johannes Klein, Axel Kahnt, Sabine Becker, Ralph Puchta, Biprajit Sarkar, Ivana Ivanović-Burmazović
A dinuclear ruthenium complex bridged by 2,3,5,6-pyrazinetetracarboxylic acid (μ-LH2(2-)) was synthesized and characterized by X-ray crystallography, cyclic voltammetry under ambient and elevated pressures, electron paramagnetic resonance (EPR) and UV/vis-NIR (NIR = near-infrared) spectroelectrochemistry, pulse radiolysis, and computational methods. We probed for the first time in the field of mixed-valency the use of high-pressure electrochemical methods. The investigations were directed toward the influence of the protonation state of the bridging ligand on the electronic communication between the ruthenium ions, since such behavior is interesting in terms of modulating redox chemistry by pH...
November 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29155336/evaluation-of-the-combined-effect-of-nir-laser-and-ionizing-radiation-on-cellular-damages-induced-by-iudr-loaded-plga-coated-nano-graphene-oxide
#18
Samira Kargar, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Seied Rabi Mahdavi
Glioma is one of the most common malignant cancers of the central nervous system (CNS). Radiatherapy and chemotherapy may be used to slow the growth of tumors that cannot be removed with surgery. The current study developed a combination therapy tool using Nanographene oxide (NGO) functionalized with poly lactic-co-glycolic acid (PLGA) as a carrier of 5-iodo-2-deoxyuridine (IUdR) for glioma cancer treatment. U87MG cells were treated in different groups with IUdR, PLGA-coated Nanographene oxide (PLGA-NGO), IUdR-loaded PLGA-coated Nanographene oxide (IUdR-PLGA-NGO), 2Gy 6MV X-ray radiation, and near-infrared region (NIR) laser radiation...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29154795/vision-improvement-in-pilots-with-presbyopia-following-perceptual-learning
#19
Anna Sterkin, Yuval Levy, Russell Pokroy, Maria Lev, Liora Levian, Ravid Doron, Oren Yehezkel, Moshe Fried, Yael Frenkel-Nir, Barak Gordon, Uri Polat
Israeli Air Force (IAF) pilots continue flying combat missions after the symptoms of natural near-vision deterioration, termed presbyopia, begin to be noticeable. Because modern pilots rely on the displays of the aircraft control and performance instruments, near visual acuity (VA) is essential in the cockpit. We aimed to apply a method previously shown to improve visual performance of presbyopes, and test whether presbyopic IAF pilots can overcome the limitation imposed by presbyopia. Participants were selected by the IAF aeromedical unit as having at least initial presbyopia and trained using a structured personalized perceptual learning method (GlassesOff application), based on detecting briefly presented low-contrast Gabor stimuli, under the conditions of spatial and temporal constraints, from a distance of 40 cm...
November 14, 2017: Vision Research
https://www.readbyqxmd.com/read/29154696/applied-machine-learning-method-to-predict-children-with-adhd-using-prefrontal-cortex-activity-a-multicenter-study-in-japan
#20
Akira Yasumura, Mikimasa Omori, Ayako Fukuda, Junichi Takahashi, Yukiko Yasumura, Eiji Nakagawa, Toshihide Koike, Yushiro Yamashita, Tasuku Miyajima, Tatsuya Koeda, Masao Aihara, Hisateru Tachimori, Masumi Inagaki
OBJECTIVE: To establish valid, objective biomarkers for ADHD using machine learning. METHOD: Machine learning was used to predict disorder severity from new brain function data, using a support vector machine (SVM). A multicenter approach was used to collect data for machine learning training, including behavioral and physiological indicators, age, and reverse Stroop task (RST) data from 108 children with ADHD and 108 typically developing (TD) children. Near-infrared spectroscopy (NIRS) was used to quantify change in prefrontal cortex oxygenated hemoglobin during RST...
November 1, 2017: Journal of Attention Disorders
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