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Wenzhi Ren, M Zubair Iqbal, Leyong Zeng, Tianxiang Chen, Yuanwei Pan, Jinshun Zhao, Hao Yin, Lili Zhang, Jichao Zhang, Aiguo Li, Aiguo Wu
TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO2) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer...
July 27, 2017: Nanoscale
Joshua E Zweig, Timothy R Newhouse
A new class of bidirectionally quantitative photoswitches based on the hemithioindigo scaffold is reported. Incorporation of a pyrrole hydrogen-bond donor leads to a bathochromic shift allowing for quantitative bidirectional isomerization. Additionally, extending conjugation from the electron-rich pyrrole results in quantitative visible-light photoswitches, as well as photoswitches that isomerize with red and NIR light. The presence of the hydrogen bond leading to the observed redshift is supported by both computational and spectroscopic evidence...
July 27, 2017: Journal of the American Chemical Society
Doron Shabat, Nir Hananya, Ori Green, Rachel Blau, Ronit Satchi-Fainaro
Singlet oxygen is among the ROS with the shortest life-time in aqueous media due to its extremely high reactivity. Therefore, designing sensors for detection of 1O2 is perhaps one the most challenging tasks in the field of molecular probes. Here we report a highly selective and sensitive chemiluminescence probe (SOCL-CPP) for detection of 1O2 in living cells. The probe reacts with 1O2 to form a dioxetane that spontaneously decomposes under physiological conditions through a chemiexcitation pathway to emit green light with extraordinary intensity...
July 27, 2017: Angewandte Chemie
Marek Grzybowski, Masayasu Taki, Shigehiro Yamaguchi
The substitution of an oxygen atom in rhodols with a phosphine oxide (P=O) moiety affords P=O-bridged rhodols as a new type of near-infrared (NIR) fluorophores. This compound class can be readily accessed upon exposure of the corresponding rhodamines to aqueous basic conditions. The electron-withdrawing effect of the P=O group facilitates the hydrolytic deamination, and, moreover, prolonged exposure to aqueous basic conditions generates P=O-bridged fluoresceins, i.e., a series of three P=O-bridged xanthene dyes is available in one simple operation...
July 27, 2017: Chemistry: a European Journal
Md Arafat Mahmud, Naveen Kumar Elumalai, Mushfika Baishakhi Upama, Dian Wang, Vinicius R Gonçales, Matthew Wright, Cheng Xu, Faiazul Haque, Ashraf Uddin
Here we report a small molecule oxidant 2,3,5,6-tetrafluoro-7,7,8,8-tetracyano-quinodimethane (F4TCNQ) doped, low cost 2',7'-bis(bis(4-methoxyphenyl)amino)spiro[cyclopenta[2,1-b:3,4-b']dithiophene-4,9'-fluorene] (FDT) hole transporting layer (HTL) for efficient mixed organic cation based MA0.6FA0.4PbI3 (MA = methyl ammonium, FA = formamidinium) perovskite solar cells (PSCs), fabricated via a highly reproducible controlled nucleation assisted restricted volume solvent annealing method, having full temperature compatibility with flexible substrates...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
Kshirodra Kumar Patra, Bela D Bhuskute, Chinnakonda S Gopinath
Any solar energy harvesting technology must provide a net positive energy balance, and artificial leaf concept provided a platform for solar water splitting (SWS) towards that. However, device stability, high photocurrent generation, and scalability are the major challenges. A wireless device based on quasi-artificial leaf concept (QuAL), comprising Au on porous TiO2 electrode sensitized by PbS and CdS quantum dots (QD), was demonstrated to show sustainable solar hydrogen (490 ± 25 µmol/h (corresponds to 12 ml H2 h(-1)) from ~2 mg of photoanode material coated over 1 cm(2) area with aqueous hole (S(2-)/SO3(2-)) scavenger...
July 26, 2017: Scientific Reports
Or Friedman, Narin Carmel, Meirav Sela, Ameen Abu Jabal, Amir Inbal, Moshe Ben Hamou, Yakov Krelin, Eyal Gur, Nir Shani
BACKGROUND: Hand and face vascularized composite allotransplantation (VCA) is an evolving and challenging field with great opportunities. During VCA, massive surgical damage is inflicted on both donor and recipient tissues, which may contribute to the high VCA rejection rates. To segregate between the damage-induced and rejection phase of post-VCA responses, we compared responses occurring up to 5 days following syngeneic versus allogeneic vascularized groin flap transplantations, culminating in transplant acceptance or rejection, respectively...
2017: PloS One
Yue Guan, Hongguang Lu, Wei Li, Yadan Zheng, Zhu Jiang, Jialing Zou, Hui Gao
Photodynamic therapy (PDT) is an auspicious strategy for cancer therapy by yielding reactive oxygen species (ROS) under light irradiation. Here, we have developed near-infrared (NIR) triggered polymer encapsulated upconversion nanoparticles (UCNPs) based on aggregation-induced emission (AIE) characteristics and mitochondria target ability for PDT. The coated AIE polymer as a photosensitizer can be photoactivated by the up-converted energy of UCNPs upon 980 nm laser irradiation, which could generate ROS efficiently in mitochondria and induce cell apoptosis...
July 26, 2017: ACS Applied Materials & Interfaces
Xiaoran Deng, Kai Li, Xuechao Cai, Bin Liu, Yi Wei, Kerong Deng, Zhongxi Xie, Zhijian Wu, Ping'an Ma, Zhiyao Hou, Ziyong Cheng, Jun Lin
It is of great importance in drug delivery to fabricate multifunctional nanocarriers with intelligent targeting properties, for cancer diagnosis and therapy. Herein, hollow-structured CuS@Cu2 S@Au nanoshell/satellite nanoparticles are designed and synthesized for enhanced photothermal therapy and photoswitchable targeting theranostics. The remarkably improved photothermal conversion efficiency of CuS@Cu2 S@Au under 808 nm near-infrared (NIR) laser irradiation can be explained by the reduced bandgap and more circuit paths for electron transitions for CuS and Cu2 S modified with Au nanoparticles, as calculated by the Vienna ab initio simulation package, based on density functional theory...
July 26, 2017: Advanced Materials
Simon Tang, Ebrahim H Ghazvini Zadeh, Bosung Kim, Nikia T Toomey, Mykhailo V Bondar, Kevin D Belfield
Fluorescent contrast agents are important tools in cell biology and medical imaging due to their high sensitivity and relative availability. Diketopyrrolopyrrole (DPP) derivatives have been recently studied for applications in bioimaging, but certain drawbacks due to their inherent structure have stifled progress towards their widespread implementation. Aggregation caused quenching (ACQ) associated with π-π stacking in relatively rigid extended conjugation systems as well as hydrophobicity of previously reported DPPs make most unsuitable for biological imaging applications...
July 26, 2017: Organic & Biomolecular Chemistry
Anatoly P Pushkarev, Tatyana V Balashova, Andrey A Kukinov, Maxim V Arsenyev, Artem N Yablonskiy, Denis I Kryzhkov, Boris A Andreev, Roman V Rumyantcev, Georgy K Fukin, Mikhail N Bochkarev
Herein, complexes [ZnL]2 (1), {(H2O)Zn(μ-L)Yb[OCH(CF3)2]3} (2), {[(CF3)2HCO]Zn(μ-L)Yb[OCH(CF3)2](μ-OH)}2 (3), and [(H2O)Ln2(L)3] (Ln = Yb (4) and Gd (5)) containing a bridging Schiff-base ligand (H2L = N,N'-bis(3-methoxy salicylidene)phenylene-1,2-diamine) were synthesized. The compounds 1-4 were structurally characterized. The ytterbium derivatives 2-4 exhibited bright NIR metal-centred photoluminescence (PL) of Yb(3+) ion under one- (λex = 380 nm) and two-photon (λex = 750 nm) excitation. The superior luminescence properties of complex 2, which was suggested as a marker for NIR bioimaging, were explained via the strong absorption of the 375 nm LMCT state of the ZnL chromophore, efficient energy transfer from ZnL towards Yb(3+) through a reversible ligand-to-lanthanide electron transfer process, and absence of luminescence quenchers (C-H and O-H groups) in the first coordination sphere of the rare-earth atom...
July 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Chunlan Liu, Shu Lu, Limin Yang, Peijie Chen, Peiming Bai, Qiuquan Wang
Quantitative information of targeted analyte in a complex biological system is the most basic premise for understanding its involved mechanisms, and thus precise diagnosis of a disease if it is a so-called biomarker. Here, we designed and synthesized a neodymium (Nd)-cored tag [1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DOTA)-Nd complex together with a light-harvesting antenna aminofluorescein (AMF, λex/em = 494/520 nm), AMF-DOTA-Nd] with duplex signals, second near-infrared (NIR) window luminescence (λem = 1065 nm, 2...
July 26, 2017: Analytical Chemistry
Paul Fefer, Roy Beigel, Shaul Atar, Doron Aronson, Arthur Pollak, Doron Zahger, Elad Asher, Zaza Iakobishvili, Nir Shlomo, Ronny Alcalai, Michal Einhorn-Cohen, Amit Segev, Ilan Goldenberg, Shlomi Matetzky
BACKGROUND: Few data are available regarding the optimal management of ST-elevation myocardial infarction patients with clinically defined spontaneous reperfusion (SR). We report on the characteristics and outcomes of patients with SR in the primary percutaneous coronary intervention era, and assess whether immediate reperfusion can be deferred. METHODS AND RESULTS: Data were drawn from a prospective nationwide survey, ACSIS (Acute Coronary Syndrome Israeli Survey)...
July 25, 2017: Journal of the American Heart Association
Ronghua Liu, Lian Li, Wenping Yin, Dongbo Xu, Hengchang Zang
The fluidized bed granulation and pellets coating technologies are widely used in pharmaceutical industry, because the particles made in a fluidized bed have good flowability, compressibility, and the coating thickness of pellets are homogeneous. With the popularization of process analytical technology (PAT), real-time analysis for critical quality attributes (CQA) was getting more attention. Near-infrared (NIR) spectroscopy, as a PAT tool, could realize the real-time monitoring and control during the granulating and coating processes, which could optimize the manufacturing processes...
July 22, 2017: International Journal of Pharmaceutics
Martina Nowak-Machen
The perioperative management of complex patients in a highly technical and subspecialized environment is the domain of the cardiac anesthesiologist. Evidence suggests that hemodynamic management using goal directed hemodynamic therapy (GDHT) improves patient outcome. Organ protection remains a main concern during cardiac surgery using extracorporeal circulation. Mortality can be decreased when remote ischemic preconditioning techniques (RIPC) are being used. Neurological outcomes can be improved with near-infrared-spectometry (NIRS), volatile anesthetics increase myocardial protection through preconditioning and perioperative echocardiography increases overall patient survival...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Chunfeng Hang, Yan Zou, Yinan Zhong, Zhiyuan Zhong, Fenghua Meng
Hyaluronic acid (HA) is an endogenous polysaccharide that shows intrinsic targetability to CD44+ cancer cells. Here, we developed NIR and UV-responsive degradable nanogels from hyaluronic acid-g-7-N,N-diethylamino-4-hydroxymethylcoumarin (HA-CM) for CD44 targeted and remotely controlled intracellular doxorubicin (DOX) delivery. Nanometer-sized HA-CM nanogels could readily load DOX, and both NIR and UV irradiation could significantly enhance DOX release from the nanogels, resulting from light-triggered cleavage of urethane bonds that connect CM to HA...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
Fabrice Thomas, Amelie Kochem, Jennifer K Molloy, Gisèle Gellon, Nicolas Leconte, Christian Philouze, Olivier Jarjayes, Florian Berthiol
Three copper(II) complexes of the (R,R)-N,N'-Bis(3,5-di-tert-butyl-2-aminobenzylidene)-1,2-diaminocyclohexane, namely [Cu(NL)], [Cu(NLH)]+ and [Cu(NLH2)]2+, were prepared and structurally characterized. In [Cu(NLH2)]2+ the copper ion lies in an octahedral geometry with the aniline groups coordinated in equatorial positions. In [Cu(NL)] the anilines are deprotonated (anilido moieties) and coordinated to an almost square metal ion. Complex [Cu(NL)] displays two oxidation waves at E1/2ox,1 = -0.14 V and E1/2ox,2 = 0...
July 25, 2017: Chemistry: a European Journal
Michele Diana, Luc Soler, Vincent Agnus, Antonio D'Urso, Michel Vix, Bernard Dallemagne, Vanina Faucher, Catherine Roy, Didier Mutter, Jacques Marescaux, Patrick Pessaux
OBJECTIVE: We aimed to prospectively evaluate NIR-C, VR-AR, and x-ray intraoperative cholangiography (IOC) during robotic cholecystectomy. BACKGROUND: Near-infrared cholangiography (NIR-C) provides real-time, radiation-free biliary anatomy enhancement. Three-dimensional virtual reality (VR) biliary anatomy models can be obtained via software manipulation of magnetic resonance cholangiopancreatography, enabling preoperative VR exploration, and intraoperative augmented reality (AR) navigation...
July 24, 2017: Annals of Surgery
Tania S Rizvi, Fazal Mabood, Liaqat Ali, Mohammed Al-Broumi, Hamida K M Al Rabani, Javid Hussain, Farah Jabeen, Suryyia Manzoor, Ahmed Al-Harrasi
INTRODUCTION: Citrullus colocynthis (L.) Schrad is extensively used to treat diabetes, obesity, fever, cancer, amenorrhea, jaundice, leukemia, rheumatism, and respiratory diseases. Chemical studies have indicated the presence of several cucurbitacins, flavones, and other polyphenols in this plant. These phytochemical constituents are responsible for the interesting antioxidant and other biological activities of C. colocynthis. OBJECTIVE: In the present study, for the first time, near infrared (NIR) spectroscopy coupled with partial least square (PLS) regression analysis was used to quantify the polyphenolic phytochemicals of C...
July 25, 2017: Phytochemical Analysis: PCA
Mindan Lu, Ning Kang, Chuan Chen, Liuqing Yang, Yang Li, Minghui Hong, Xiangang Luo, Lei Ren, Xiumin Wang
Near infrared (NIR) triggered cyanine dyes have attracted considerable attentions in multi-modal tumor theranostics. However, near infrared (NIR) cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacies for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent of AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0...
July 25, 2017: Nanotechnology
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