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Apples and cancer

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https://www.readbyqxmd.com/read/28494095/comparison-of-192-ir-169-yb-and-60-co-high-dose-rate-brachytherapy-sources-for-skin-cancer-treatment
#1
Habib Safigholi, Ali S Meigooni, William Y Song
PURPOSE: To evaluate the possibility of utilizing the high-dose rate (HDR) (169) Yb and (60) Co sources, in addition to (192) Ir, for the treatment of skin malignancies with conical applicators. METHODS: Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of single (169) Yb (4140), (60) Co (Co0.A86), and (192) Ir (mHDR-V2) brachytherapy sources in a water phantom and compared their results against published data. A standard conical tungsten alloy Leipzig-style applicator (Stand...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28441790/eradicating-breast-cancer-longevity-impact-on-kuwaiti-women
#2
Muhammad Ali Al Ramadhan
Objective: To explore salient trends in incidence and mortality from breast cancer among Kuwaiti females and to quantify the number of years that could be saved if breast cancer deaths were eliminated. Methods: Appling life table technique, the paper constructs a bridged, multiple decrement and cancer-elimination life tables for Kuwaiti females. Data sources include Kuwait Cancer Control Center Registry along with vital statistics on mortality by age groups, nationality, and causes of death according to ICD-10 revision...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28422286/isorhapontigenin-induced-cell-growth-inhibition-and-apoptosis-by-targeting-egfr-related-pathways-in-prostate-cancer
#3
Cuicui Zhu, Qingyi Zhu, Zhaomeng Wu, Yingying Yin, Dan Kang, Shan Lu, Ping Liu
Isorhapontigenin (ISO), a naturally phytopolyphenol compound existing in Chinese herb, apples, and various vegetables, has attracted extensive interest in recent years for its diverse pharmacological characteristics. Increasing evidences reveal that ISO can inhibit cancer cell growth by induced apoptosis, however, the molecular mechanisms is not fully understood. In this study, we found for the first time that ISO apparently induced cell growth inhibition and apoptosis by targeting EGFR and its downstream signal pathways in prostate cancer (PCa) cells both in vitro and in vivo, whereas no obviously effect on normal prostate cells...
April 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28418843/cd24-expression-and-differential-resistance-to-chemotherapy-in-triple-negative-breast-cancer
#4
Xinyu Deng, Sophia Apple, Hong Zhao, Jeongyoon Song, Minna Lee, William Luo, Xiancheng Wu, Debra Chung, Richard J Pietras, Helena R Chang
Breast cancer (BC) is a leading cause of cancer-related death in women. Adjuvant systemic chemotherapies are effective in reducing risks of recurrence and have contributed to reduced BC mortality. Although targeted adjuvant treatments determined by biomarkers for endocrine and HER2-directed therapies are largely successful, predicting clinical benefit from chemotherapy is more challenging. Drug resistance is a major reason for treatment failures. Efforts are ongoing to find biomarkers to select patients most likely to benefit from chemotherapy...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28389232/an-apple-oligogalactan-enhances-the-growth-inhibitory-effect-of-5-fluorouracil-on-colorectal-cancer
#5
Yuhua Li, Lei Fan, Yinbo Niu, Wenguang Mian, Feng Zhang, Ming Xie, Yang Sun, Qibing Mei
Treatment of colorectal cancer (CRC) remains a clinical challenge, since current therapies are associated with obvious side effects and high expenses. These limitations highlight an urgent need for developing novel and safe treatment strategies. It is suggested that combinatorial strategies could be more effective and much safer than monotherapy in cancer treatment. In our previous study, an apple oligogalactan (AOG) has been found to show beneficial effect on treating CRC. This study tried to investigate whether AOG could enhance the growth inhibitory effect of 5-FU in human CRC cells (HT-29 and SW-620), a mouse model of colitis associated colorectal cancer and a murine model of xenograft tumor...
June 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28381226/annurca-apple-m-pumila-miller-cv-annurca-extracts-act-against-stress-and-ageing-in-s-cerevisiae-yeast-cells
#6
Mariarita Stirpe, Vanessa Palermo, Michele Maria Bianchi, Romano Silvestri, Claudio Falcone, Giancarlo Tenore, Ettore Novellino, Cristina Mazzoni
BACKGROUND: During the past years, a number of studies have demonstrated the positive effect of apple on ageing and different diseases such as cancer, degenerative and cardiovascular diseases. The unicellular yeast Saccharomyces cerevisiae represents a simple eukaryotic model to study the effects of different compounds on lifespan. We previously demonstrated that apple extracts have anti-ageing effects in this organism because of their antioxidant properties. In particular, the effect is related to the presence in this fruit of polyphenols, which give a large contribution to the antioxidant activity of apples...
April 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28377882/subtle-hippocampal-deformities-in-breast-cancer-survivors-with-reduced-episodic-memory-and-self-reported-cognitive-concerns
#7
Alexandra C Apple, Anthony J Ryals, Kathryn I Alpert, Lynne I Wagner, Pei-An Shih, Mehmet Dokucu, David Cella, Frank J Penedo, Joel L Voss, Lei Wang
Cancer survivors have lingering cognitive problems, however the anatomical basis for these problems has yet to be fully elucidated. Clinical studies as well as animal models of chemotherapy have pinpointed cell and volume loss to the hippocampus, however, few studies have performed shape analysis of the hippocampus on cancer survivors. This study used high-dimensional deformation mapping analysis to test whether localized hippocampal deformation differs in breast cancer survivors who received adjuvant chemotherapy coupled with hormone blockade therapy, and if deformation was related to subjective self-reported concerns and cognitive performance...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28341106/the-apple-trial-feasibility-and-activity-of-azd9291-osimertinib-treatment-on-positive-plasma-t790m-in-egfr-mutant-nsclc-patients-eortc-1613
#8
Jordi Remon, Jessica Menis, Baktiar Hasan, Aleksandra Peric, Eleonora De Maio, Silvia Novello, Martin Reck, Thierry Berghmans, Bartosz Wasag, Benjamin Besse, Rafal Dziadziuszko
The AZD9291 (Osimertinib) Treatment on Positive PLasma T790M in EGFR-mutant NSCLC Patients (APPLE) trial is a randomized, open-label, multicenter, 3-arm, phase II study in advanced, epidermal growth factor receptor (EGFR)-mutant and EGFR tyrosine kinase inhibitor (TKI)-naive non-small-cell lung cancer (NSCLC) patients, to evaluate the best strategy for sequencing gefitinib and osimertinib treatment. Advanced EGFR-mutant NSCLC patients, with World Health Organization performance status 0-2 who are EGFR TKI treatment-naive and eligible to receive first-line treatment with EGFR TKI will be randomized to: In all arms, a plasmatic ctDNA T790M test will be performed by a central laboratory at the Medical University of Gdansk (Poland) but will be applied as a predictive marker for making treatment decisions only in arm B...
March 1, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28338764/fruit-and-vegetable-intake-and-the-risk-of-cardiovascular-disease-total-cancer-and-all-cause-mortality-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#9
Dagfinn Aune, Edward Giovannucci, Paolo Boffetta, Lars T Fadnes, NaNa Keum, Teresa Norat, Darren C Greenwood, Elio Riboli, Lars J Vatten, Serena Tonstad
Background: Questions remain about the strength and shape of the dose-response relationship between fruit and vegetable intake and risk of cardiovascular disease, cancer and mortality, and the effects of specific types of fruit and vegetables. We conducted a systematic review and meta-analysis to clarify these associations. Methods: PubMed and Embase were searched up to 29 September 2016. Prospective studies of fruit and vegetable intake and cardiovascular disease, total cancer and all-cause mortality were included...
February 22, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28332451/inhibitory-effect-of-fruit-juices-on-the-doxorubicin-metabolizing-activity-of-carbonyl-reductase-1
#10
Takeshi Miura, Katsutoshi Nagai, Shingo Kaneshiro, Ayako Taketomi, Toshikatsu Nakabayashi, Hiroki Konishi, Toru Nishinaka, Tomoyuki Terada
BACKGROUND AND OBJECTIVE: Doxorubicin, an anthracycline anti-cancer drug, is effective for breast cancer and childhood lymphoma. Chronic cardiotoxicity has been known as a critical adverse effect of doxorubicin and is attributed to its metabolite doxorubicinol produced by carbonyl reductase 1 (CBR1, SDR21C1). Some flavonoids have been reported to act as inhibitors for CBR1, therefore, commercially available juices containing flavonoids are likely to be applicable as a prophylactic treatment against doxorubicin-induced cardiotoxicity by suppression doxorubicinol production...
March 9, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28319346/determination-of-oleanolic-acid-in-human-plasma-and-its-association-with-olive-oil-intake-in-healthy-spanish-adults-within-the-epic-spain-cohort-study
#11
Genevieve Buckland, Antoni Pastor, Leila Lujan-Barroso, Carlos Alberto Gonzalez, Noemie Travier, Pilar Amiano, José María Huerta, Antonio Agudo, Carmen Navarro, María Dolores Chirlaque, Maria-José Sánchez, Miguel Rodríguez-Barranco, Aurelio Barricarte, Eva Ardanaz, Miren Dorronsoro, Amaia Molinuevo, José Ramón Quirós, Rafael de la Torre
SCOPE: Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake. METHODS AND RESULTS: The final study sample included 141 individuals randomly selected from the European Prospective Investigation into Cancer and Nutrition Spanish cohort. Dietary olive oil intake was estimated using validated dietary history questionnaires...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28286910/the-molecular-mechanism-underlying-anthocyanin-metabolism-in-apple-using-the-mdmyb16-and-mdbhlh33-genes
#12
Haifeng Xu, Nan Wang, Jingxuan Liu, Changzhi Qu, Yicheng Wang, Shenghui Jiang, Ninglin Lu, Deyun Wang, Zongying Zhang, Xuesen Chen
MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple...
March 12, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28270687/osmac-approach-leads-to-new-fusarielin-metabolites-from-fusarium-tricinctum
#13
Catalina F Pérez Hemphill, Parichat Sureechatchaiyan, Matthias U Kassack, Raha S Orfali, Wenhan Lin, Georgios Daletos, Peter Proksch
Using the OSMAC (One Strain MAny Compounds) approach, the fungal endophyte Fusarium tricinctum was cultivated on fruit and vegetable juice-supplemented solid rice media. This led to an up to 80-fold increase in the accumulation of the new natural product fusarielin J (1), as well as to the induction of two new natural products fusarielin K (2) and fusarielin L (3) and the known derivatives fusarielins A (4) and B (5). Compounds 2-5 were not detected when the fungus was grown on rice media lacking either fruit or vegetable juice...
March 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28247857/adherence-to-a-healthy-nordic-food-index-and-risk-of-myocardial-infarction-in-middle-aged-danes-the-diet-cancer-and-health-cohort-study
#14
V B Gunge, I Andersen, C Kyrø, C P Hansen, C C Dahm, J Christensen, A Tjønneland, A Olsen
BACKGROUND/OBJECTIVES: For decades, the Mediterranean diet has been in focus regarding healthy eating as it has been associated with reduced risk of non-communicable diseases. Less interest has been given to health benefits of other regional diets. The aim of the present study was to assess whether adherence to a healthy Nordic food index was associated with lower risk of myocardial infarction (MI) among middle-aged Danes. SUBJECTS/METHODS: Data were obtained from the Danish Diet, Cancer and Health cohort study of 57 053 men and women aged 50-64 years recruited between 1993 and 1997...
March 1, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28216882/anticancer-potential-of-nutraceutical-formulations-in-mnu-induced-mammary-cancer-in-sprague-dawley-rats
#15
Gummalla Pitchaiah, Annapurna Akula, Vishala Chandi
BACKGROUND: Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. OBJECTIVE: To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rats. MATERIALS AND METHODS: Different nutraceutical formulations were prepared using fine powders of amla, apple, garlic, onion, papaya, turmeric, and wheat grass with and without cow urine distillate...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28214962/apple-core-sign-in-colorectal-cancer
#16
REVIEW
Eduardo Kaiser Ururahy Nunes Fonseca, Cassia Franco Tridente, Renata Emy Ogawa, Fernando Ide Yamauchi, Ronaldo Hueb Baroni
No abstract text is available yet for this article.
February 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28195576/the-mole-mapper-study-mobile-phone-skin-imaging-and-melanoma-risk-data-collected-using-researchkit
#17
Dan E Webster, Christine Suver, Megan Doerr, Erin Mounts, Lisa Domenico, Tracy Petrie, Sancy A Leachman, Andrew D Trister, Brian M Bot
Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as phone cameras enable self-examination and documentation of mole abnormalities that may signal a progression towards melanoma. Aggregation and open sharing of this participant-collected data can be foundational for research and the development of early cancer detection tools. Here we describe data from Mole Mapper, an iPhone-based observational study built using the Apple ResearchKit framework...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28179225/influence-of-temperate-subtropical-and-tropical-fruit-consumption-on-risk-of-type-2-diabetes-in-an-asian-population
#18
Derrick Johnston Alperet, Lesley M Butler, Woon-Puay Koh, Jian-Min Yuan, Rob M van Dam
Background: Findings on the relation between fruit consumption and the risk of type 2 diabetes mellitus (T2DM) have been inconsistent.Objectives: We examined whether the consumption of total, temperate, subtropical, and tropical fruit is associated with T2DM risk and whether differences in the carbohydrate quality of fruit influence T2DM risk in Asians.Design: We included 45,411 participants in the Singapore Chinese Health Study who were 45-74 y old and had no diabetes, cancer, or cardiovascular disease at recruitment (1993-1998)...
March 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28153807/amyloidosis-a-cancer-derived-paraproteinemia-and-kidney-involvement
#19
REVIEW
Jolanta Małyszko, Klaudia Kozłowska, Jacek Stanisław Małyszko
Amyloidosis is the general term describing the extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of proteins. There are multiple different human protein precursors of amyloid fibrils. Amyloid deposits are stained using Congo Red and show typical apple-green birefringence in polarized microscopy. Nowadays, a novel technique LMD/MS technique or laser microdissection combined with mass spectrometry help to diagnose amyloidosis. Amyloidosis of the kidney is typically classified as being either one of two types: AL or AA...
March 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28146364/antimutagenic-antirecombinogenic-and-antitumor-effect-of-amygdalin-in-a-yeast-cell-based-test-and-mammalian-cell-lines
#20
Atanaska Todorova, Margarita Pesheva, Ivan Iliev, Krum Bardarov, Teodora Todorova
Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, cough suppression, and quenching thirst. The aim of the present study is to determine the mutagenic and recombinogenic effects of amygdalin in a test system Saccharomyces cerevisiae and to evaluate its potential antitumor effect in a yeast cell-based test and colon cancer cell lines...
April 2017: Journal of Medicinal Food
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