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Apples and cancer

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https://www.readbyqxmd.com/read/29129972/inflammation-and-colorectal-cancer
#1
Apple G Long, Emma T Lundsmith, Kathryn E Hamilton
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors. Purpose of review: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC...
August 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/29065679/localized-gastric-amyloidosis-with-kappa-and-lambda-light-chain-co-expression
#2
Yong Hwan Ahn, Ye Young Rhee, Suck Chei Choi, Geom Seog Seo
Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program, and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsy specimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic active gastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and apple-green birefringence was shown using polarized light microscopy...
October 26, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28976640/biophysical-interactions-between-pancreatic-cancer-cells-and-pristine-carbon-nanotube-substrates-potential-application-for-pancreatic-cancer-tissue-engineering
#3
Brigitta Matta-Domjan, Alice King, Stella Totti, Csaba Matta, George Dover, Patricia Martinez, Anvar Zakhidov, Roberto La Ragione, Hugo Macedo, Izabela Jurewicz, Alan Dalton, Eirini G Velliou
Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering...
October 4, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28950048/development-of-next-generation-cardiovascular-therapeutics-through-bio-assisted-nanotechnology
#4
REVIEW
Rajesh Lakshmanan, Nilanjana Maulik
Cardiovascular diseases (CVDs) rank, next to cancer and stroke, among the deadliest diseases in the world. Among the major CVDs, acute myocardial infarction is a life-threatening disorder resulting from permanent damage to the left ventricular cardiac tissue. The major coronary arteries that supply blood to the functional left ventricle become blocked due to thrombotic plaque occlusion. During myocardial ischemia, oxidative stress and free radicals destroy healthy cardiomyocytes, smooth muscle cells, and endothelial cells, followed by degradation of the extracellular matrix, which results in ventricular wall-thinning and dilation...
September 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28947887/link-between-diet-and-chemotherapy-related-gastrointestinal-side-effects
#5
Marcin Mardas, Radosław Madry, Marta Stelmach-Mardas
AIM OF THE STUDY: To evaluate an association between food products consumption, dietary intake and the incidence of selected gastrointestinal symptoms (nausea, vomiting, diarrhea and constipation) in cancer patients undergoing chemotherapy. MATERIAL AND METHODS: Fifty six women receiving chemotherapy for ovarian cancer were eligible for the study. Anthropometrical measurements were assessed. The dietary intake was evaluated by 24-hours food records. The association between the consumption of selected food products and gastrointestinal symptoms incidences was assessed by modified semi-quantitative food frequency questionnaire including 77-different food items that was developed and applied in cancer patients undergoing chemotherapy...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28914992/an-effective-thermal-therapy-against-cancer-using-an-e-jet-3d-printing-method-to-prepare-implantable-magnetocaloric-mats
#6
Yikun Yang, Chunyi Tong, Juchang Zhong, Ruiying Huang, Weihong Tan, Zhikai Tan
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe3 O4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo...
September 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28912138/sarcomatoid-renal-cell-carcinoma-the-apple-doesn-t-fall-far-from-the-tree
#7
Paulo Bergerot, Neeraj Agarwal, Sumanta K Pal, Jeremy Jones
The most comprehensive sequencing effort of sarcomatoid renal cell carcinoma (sRCC) to date reinforces the notion that the sarcomatoid component is closely related to the epithelial component of the cancer. This work also challenges the notion that sRCC evolves from low-grade RCC and identifies potential mediators of sarcomatoid differentiation. Clin Cancer Res; 23(21); 6381-3. ©2017 AACRSee related article by Wang et al., p. 6686.
November 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28911529/an-apple-a-day-to-prevent-cancer-formation-reducing-cancer-risk-with-flavonoids
#8
REVIEW
Shih-Hsin Tu, Li-Ching Chen, Yuan-Soon Ho
The purpose of this review is to update and discuss key findings from in vitro and in vivo studies on apple and its biocompounds, with a special focus on its anticancer role. Several studies have proposed that apple and its extracts exhibit a variety of biological functions that may contribute to health benefits including beneficial effects against chronic heart and vascular disorders, respiratory and pulmonary dysfunction, diabetes, obesity, and cancer. In this review, we summarize the molecular mechanism(s) of various components in apple, as established in previous studies that indicated their growth-inhibitory effects in various cancer cell types...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28885478/use-of-electronic-tablets-for-patient-education-on-flushing-peripherally-inserted-central-catheters
#9
Patricia L Petroulias
The purpose of this study was to examine the efficacy of using an electronic tablet to provide patient education for flushing peripherally inserted central catheters (PICCs) as a way to reduce the incidence of occlusion. Eleven patients, newly diagnosed with cancer, participated in a pilot study that used a video on PICC flushing and remote coaching using FaceTime (Apple, Cupertino, CA) to teach patients how to maintain their PICCs in their homes. At the end of the 6-week intervention, no adverse outcomes (occlusions or infections) were noted among the patients who participated in the study...
September 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/28843255/development-of-a-colorectal-cancer-screening-intervention-for-iranian-adults-appling-intervention-mapping
#10
Fereshteh Besharati, Akram Karimi-Shahanjarini, Seyed Mohammad Mehdi Hazavehei, Saeid Bashirian, Fahimeh Bagheri, Javad Faradmal
Background: While the incidence rate of the colorectal cancer (CRC) has been increasing over the last three decades in Iran, very limited interventions to increase CRC screening have been developed for Iranian population. The purpose of this study was to describe the use of Intervention Mapping (IM) for applying theory and evidence and considering local contexts to develop a CRC screening program among adults in Iran. Materials and Methods: From April 2014 to July 2016 following the IM process, six steps were formulated and implemented...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28767099/fisetin-induces-apoptosis-through-p53-mediated-up-regulation-of-dr5-expression-in-human-renal-carcinoma-caki-cells
#11
Kyoung-Jin Min, Ju-Ock Nam, Taeg Kyu Kwon
Fisetin is a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions. Since fisetin can elicit anti-cancer effects, including anti-proliferation and anti-migration, we investigated whether fisetin induced apoptosis in human renal carcinoma (Caki) cells. Fisetin markedly induced sub-G1 population and cleavage of poly (ADP-ribose) polymerase (PARP), which is a marker of apoptosis, and increased caspase activation. We found that pan-caspase inhibitor (z-VAD-fmk) inhibited fisetin-induced apoptosis...
August 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28766690/pro-oxidant-and-pro-apoptotic-activity-of-polyphenol-extract-from-annurca-apple-and-its-underlying-mechanisms-in-human-breast-cancer-cells
#12
Stefania D'Angelo, Elisa Martino, Concetta Paola Ilisso, Maria Libera Bagarolo, Marina Porcelli, Giovanna Cacciapuoti
Among nutraceuticals, polyphenols represent the most intriguing and studied class of compounds that can be therapeutics for a large spectrum of the most common diseases, including cancer. Although polyphenols are well known as potent antioxidants, a pro-oxidant effect has been associated with a pro-apoptotic function of these compounds in various types of tumor cells. Annurca apple, a southern Italian variety, is characterized by an extremely high content of polyphenols and displays a stronger antioxidant activity compared with other varieties...
September 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28748189/apples-and-pears-a-comparison-of-two-sources-of-national-lung-cancer-audit-data-in-england
#13
Aamir Khakwani, Ruth H Jack, Sally Vernon, Rosie Dickinson, Natasha Wood, Susan Harden, Paul Beckett, Ian Woolhouse, Richard B Hubbard
In 2014, the method of data collection from NHS trusts in England for the National Lung Cancer Audit (NLCA) was changed from a bespoke dataset called LUCADA (Lung Cancer Data). Under the new contract, data are submitted via the Cancer Outcome and Service Dataset (COSD) system and linked additional cancer registry datasets. In 2014, trusts were given opportunity to submit LUCADA data as well as registry data. 132 NHS trusts submitted LUCADA data, and all 151 trusts submitted COSD data. This transitional year therefore provided the opportunity to compare both datasets for data completeness and reliability...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28698459/dietary-natural-products-for-prevention-and-treatment-of-breast-cancer
#14
REVIEW
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang, Hua-Bin Li
Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28661574/hyperthermia-effect-and-antibacterial-efficacy-of-fe-3-co-2-co-substitutions-in-%C3%AE-ca3-po4-2-for-bone-cancer-and-defect-therapy
#15
Ram Kishore Singh, M Srivastava, N K Prasad, P H Shetty, S Kannan
The combined effect of cobalt and iron substitutions in β-Ca3 (PO4 )2 as a potent material for application in hyperthermia and as a bone substitute is presented. Structural analysis reveals the preferential accommodation of Co(2+) and Fe(3+) at the Ca(2+) (5) sites of β-Ca3 (PO4 )2 until the limit of ∼10 mol % and, thereafter, prefer Ca(2+) (4) lattice sites. Occupancy of both the Co(2+) and Fe(3+) ions induces a significant contraction of the β-Ca3 (PO4 )2 unit cell. The Co(2+) /Fe(3+) co-substitutions in β-Ca3 (PO4 )2 display magnetic characteristics that enhances hyperthermia effect...
June 29, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#16
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28579463/modified-apple-polysaccharide-prevents-colitis-through-modulating-il-22-and-il-22bp-expression
#17
Yuhua Li, Lei Fan, Tianle Tang, Yuan Tang, Ming Xie, Xiaocong Zeng, Yang Sun, Qibing Mei
Chronic intestinal inflammation enhances cell proliferation, angiogenesis, and migration, then promotes the development of colorectal cancer (CRC). Many ingredients of apples have been proven to have anti-inflammatory properties, and show benefits for colitis treatment. In our previous studies, we found modified apple polysaccharide (MAP) could prevent colitis associated colorectal carcinogenesis effectively. Herein, we further our study to observe the effect of MAP on dextran sodium sulfate (DSS)-induced colitis and to investigate the possible mechanisms...
October 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28561991/development-of-a-novel-bioactive-glass-suitable-for-osteosarcoma-related-bone-grafts
#18
Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D Waldman, Mark R Towler
In this study, zinc borate-based glasses with increasing gallium content (0, 2.5, 5, 10, and 15 wt % Ga) were synthesized and their effect on the viability and proliferation of preosteoblasts and osteosarcoma cancer cells were investigated. Methyl thiazolyl tetrazolium (MTT) cell viability assays using glass degradation extracts revealed that the extracts from glasses with lower Ga contents could enhance the viability of preosteoblasts, while extracts from the glass composition with 15 wt % Ga caused statistically significant reduction of their viability...
May 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28494095/comparison-of-192-ir-169-yb-and-60-co-high-dose-rate-brachytherapy-sources-for-skin-cancer-treatment
#19
Habib Safigholi, Ali S Meigooni, William Y Song
PURPOSE: To evaluate the possibility of utilizing the high-dose rate (HDR) (169) Yb and (60) Co sources, in addition to (192) Ir, for the treatment of skin malignancies with conical applicators. METHODS: Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of single (169) Yb (4140), (60) Co (Co0.A86), and (192) Ir (mHDR-V2) brachytherapy sources in a water phantom and compared their results against published data. A standard conical tungsten alloy Leipzig-style applicator (Stand...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28441790/eradicating-breast-cancer-longevity-impact-on-kuwaiti-women
#20
Muhammad Ali Al Ramadhan
Objective: To explore salient trends in incidence and mortality from breast cancer among Kuwaiti females and to quantify the number of years that could be saved if breast cancer deaths were eliminated. Methods: Appling life table technique, the paper constructs a bridged, multiple decrement and cancer-elimination life tables for Kuwaiti females. Data sources include Kuwait Cancer Control Center Registry along with vital statistics on mortality by age groups, nationality, and causes of death according to ICD-10 revision...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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