keyword
MENU ▼
Read by QxMD icon Read
search

Pain physiology

keyword
https://www.readbyqxmd.com/read/29904615/acute-pericarditis-as-a-presentation-of-adrenal-insufficiency
#1
Sukesh Manthri, Sindhura Bandaru, Abdisamad Ibrahim, Chaitanya K Mamillapalli
Acute pericarditis as a presenting sign of adrenal insufficiency is rarely reported. We present a rare case that highlights pericarditis as a clinical presentation of secondary adrenal insufficiency later complicated by cardiac tamponade. A 44-year-old lady who presented to the hospital with a one-day history of pleuritic chest pain and shortness of breath. In the emergency room, she had a blood pressure of 70/35 mmHg. Laboratory evaluation revealed white blood cell count of 16.08 k/cumm with neutrophilia, normal renal function and elevated troponin (0...
April 13, 2018: Curēus
https://www.readbyqxmd.com/read/29892247/interoceptive-awareness-skills-for-emotion-regulation-theory-and-approach-of-mindful-awareness-in-body-oriented-therapy-mabt
#2
Cynthia J Price, Carole Hooven
Emotion regulation involves a coherent relationship with the self, specifically effective communication between body, mind, and feelings. Effective emotion regulation involves the ability to accurately detect and evaluate cues related to physiological reactions to stressful events, accompanied by appropriate regulation strategies that temper and influence the emotional response. There is compelling evidence demonstrating links between poor or disrupted awareness of sensory information, or interoceptive awareness, and difficulties with emotion regulation...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29890702/cellular-and-molecular-mediators-of-bone-metastatic-lesions
#3
REVIEW
Giulia Battafarano, Michela Rossi, Francesco Marampon, Andrea Del Fattore
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29889743/perioperative-management-and-implementation-of-enhanced-recovery-programs-in-gynecologic-surgery-for-benign-indications
#4
Erin T Carey, Janelle K Moulder
Enhanced recovery after surgery (ERAS) programs are a multimodal approach to optimize the surgical experience. Intraoperative and postoperative pain management is essential because the stress of surgery results in significant neurohormonal and metabolic shifts that can influence patient analgesia. Enhanced recovery after surgery programs address the physiologic and psychological factors that contribute to pain outcomes and overall satisfaction scores. A multimodal approach to recovery throughout the perioperative surgical experience is representative of successful pathways...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29886768/human-chorionic-gonadotropin-induces-decidualization-of-ectopic-human-endometrium-more-effectively-than-forskolin-in-an-in-vivo-endometriosis-model
#5
Yvonne Koch, Pauline Wimberger, Ruth Grümmer
Endometriosis, characterized by the presence of endometrial tissue at ectopic sites, is a leading cause of pelvic pain and subfertility in women. The stromal compartment of the endometrium is considered to play a pivotal role in the establishment and persistence of endometriotic lesions, thus impaired decidualization of these cells may result in enhanced invasion capacity at ectopic sites. Consequently, stimulation of decidualization may alleviate this disease. To analyze the effect of systemically applied compounds on decidualization of ectopic endometrial tissue, endometriosis was induced by suturing human eutopic endometrium to the peritoneum of 22 NOD/SCID mice...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29886636/-assessment-of-the-quality-of-life-of-mandible-defect-after-reconstruction-with-fibula-flap
#6
N Gao, K Fu, W He
Objective: To evaluate the quality of life (QOL) of patients who underwent resection of mandible and reconstruction by fibula flap. Methods: A total of seventy six patients who underwent resection of mandible and reconstruction by fibula flap admitted to The First Affiliated Hospital of Zhengzhou University from January 2013 to August 2016 were prospectively analyzed. In the preoperative and postoperative 3 month, 12 months, the QOL of these patients were assessed by using the 14-item oral health impact profile questionnaires (OHIP), The University of Washington quality of life (UW-QOL) and the European organization for research and treatment of cancer quality of life questionnaire head and neck module (EORTC-QLQ-H&N)...
June 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29884837/genome-wide-association-study-identifies-genes-associated-with-neuropathy-in-patients-with-head-and-neck-cancer
#7
Cielito C Reyes-Gibby, Jian Wang, Sai-Ching J Yeung, Patrick Chaftari, Robert K Yu, Ehab Y Hanna, Sanjay Shete
Neuropathic pain (NP), defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system, is a debilitating chronic pain condition often resulting from cancer treatment. Among cancer patients, neuropathy during cancer treatment is a predisposing event for NP. To identify genetic variants influencing the development of NP, we conducted a genome-wide association study in 1,043 patients with squamous cell carcinoma of the head and neck, based on 714,494 tagging single-nucleotide polymorphisms (SNPs) (130 cases, 913 controls)...
June 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29882158/localization-of-cannabinoid-receptors-cb1-cb2-gpr55-and-ppar%C3%AE-in-the-canine-gastrointestinal-tract
#8
Giorgia Galiazzo, Fiorella Giancola, Agnese Stanzani, Federico Fracassi, Chiara Bernardini, Monica Forni, Marco Pietra, Roberto Chiocchetti
The endocannabinoid system (ECS) is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in endocannabinoid turnover. Modulating the activity of the ECS may influence a variety of physiological and pathophysiological processes. A growing body of evidence indicates that activation of cannabinoid receptors by endogenous, plant-derived, or synthetic cannabinoids may exert beneficial effects on gastrointestinal inflammation and visceral pain. The present ex vivo study aimed to investigate immunohistochemically the distribution of cannabinoid receptors CB1, CB2, G protein-coupled receptor 55 (GPR55), and peroxisome proliferation activation receptor alpha (PPARα) in the canine gastrointestinal tract...
June 7, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29881684/synergistic-immunoreaction-of-acupuncture-like-dissolving-microneedles-containing-thymopentin-at-acupoints-in-immune-suppressed-rats
#9
Qian Zhang, Chuncao Xu, Shiqi Lin, Huanbin Zhou, Gangtao Yao, Hu Liu, Lili Wang, Xin Pan, Guilan Quan, Chuanbin Wu
Dissolving microneedles carried drug molecules can effectively penetrate the stratum corneum of skin to improve the transdermal drug delivery. The traditional Chinese medicine acupuncture is based on the needle stimulation at a specific location (acupoint) to generate and transmit biochemical and physiological signals which alter the pathophysiological state of patients. However, the pain associated with conventional acupuncture needles and the requirement of highly trained professionals limit the development of acupuncture in non-Asian countries...
May 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29881653/preoperative-assessment-of-neural-elements-in-lumbar-spinal-stenosis-by-upright-magnetic-resonance-imaging-an-implication-for-routine-practice
#10
Gernot Lang, Marco Vicari, Alexander Siller, Eva J Kubosch, Juergen Hennig, Norbert P Südkamp, Kaywan Izadpanah, David Kubosch
Introduction Lumbar spinal stenosis (LSS) is a kinetic-dependent disease typically aggravating during spinal loading. To date, assessment of LSS is usually performed with magnetic resonance imaging (MRI). However, conventional supine MRI is associated with significant drawbacks as it does not truly reflect physiological loads, experienced by discoligamentous structures during erect posture. Consequently, supine MRI often fails to reveal the source of pain and/or disability caused by LSS. The present study sought to assess neural dimensions via MRI in supine, upright, and upright-hyperlordotic position in order to evaluate the impact of patient positioning on neural narrowing...
April 6, 2018: Curēus
https://www.readbyqxmd.com/read/29881180/progressive-osteoarthritis-during-pregnancy-several-years-following-hip-arthroscopy-for-femoroacetabular-impingement
#11
Daniel Lee Jones, Matthew Truesdale Philippi, Travis Gardner Maak, Stephen Kenji Aoki
Case: A 28-year-old with borderline left hip dysplasia who underwent arthroscopic acetabuloplasty, femoral osteochondroplasty, and labral repair for femoroacetabular impingement. She did well for 8 years, though required arthroscopic capsulolabral adhesion release 2 years after the initial procedure. After this period of stability, she developed left hip pain during pregnancy. Radiographs demonstrated progressive osteoarthritis that lead to total hip arthroplasty at age 37. Conclusion: The physiologic and hormonal changes during pregnancy leading to increased ligamentous laxity may put vulnerable patients with hip dysplasia and iatrogenic instability at increased risk for progression of osteoarthritis...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29880651/shifting-understandings-of-labour-pain-in-canadian-medical-history
#12
Whitney Wood
While pain in childbirth is a universal, cross-cultural, biological reality, individual experiences and perceptions of this pain are historically and culturally specific. At the turn of the 20th century-a key period in terms of both the medicalisation of birth and the professionalisation of obstetrics in the Canadian context-Canadian physicians understood and conceptualised 'birth pangs' in a number of varying (and at times competing) ways. Throughout the 19th century, doctors emphasised the broader utility of pain as a diagnostic tool and a physiologically necessary part of the birthing process...
June 7, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29878713/comparative-study-between-m6-c-and-mobi-c-cervical-artificial-disc-replacement-biomechanical-outcomes-and-comparison-with-normative-data
#13
My Pham, Kevin Phan, Ian Teng, Ralph J Mobbs
OBJECTIVE: Cervical spondylosis affects a huge proportion of the middle-aged population. Degenerative changes can occur in multiple regions of the cervical spine typically affecting the joints, intervertebral discs and endplates. These changes lead to compression of adjacent nervous structures, which results in radiculopathic and myelopathic pain. Various treatment modalities are currently available with non-surgical approaches the initial go to if there is no symptomatic cord compression...
May 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29878656/gaining-insight-into-the-complexity-of-pain-in-patients-with-haemophilia-state-of-the-art-review-on-pain-processing
#14
REVIEW
N A Roussel
Despite the high prevalence of recurrent, constant and/or widespread pain in patients with haemophilia (PwH), there is an immense lack of studies examining the (patho)physiology of pain in this population. This contrasts to the bulk of literature in other pain conditions, such as osteoarthritis, low back pain or rheumatoid arthritis. Understanding the complexity of pain allows to better assess and manage pain. In PwH, the first priority is always to exclude bleeding as a cause of pain. An important next step in pain assessment is the evaluation of the predominant pain mechanism (ie nociceptive, neuropathic pain or altered central pain processing) as the treatment approach will be very different according to the underlying pain mechanism...
May 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29877979/dog-attack-causing-lip-wound
#15
Gabriela Vasconcelos Maia, Amanda Lobão de Albuquerque, Talyne Albuquerque Ximenes, Tibério Gomes Magalhães, Abrahão Cavalcante Gomes de Souza Carvalho
Animal bites are relatively common occurrences reaching about 4.5 millions of people every year. The main aggressor is the domesticated dog, responsible for around 90% of the patients, with children being the most affected, with 70% of the registered patients, while with adults that number is a lot lower (15%). Bites around the head and neck require special attention. Due to the presence of noble structures and the rich local vascularization, any wounds have been immediately addressed to stop bleeding and further complications...
June 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29875640/inattentive-delirium-vs-disorganized-thinking-a-new-axis-to-subcategorize-pacu-delirium
#16
Darren F Hight, Jamie Sleigh, Joel D Winders, Logan J Voss, Amy L Gaskell, Amy D Rodriguez, Paul S García
Background: Assessment of patients for delirium in the Post Anesthesia Care Unit (PACU) is confounded by the residual effects of the varied anesthetic and analgesic regimens employed during surgery and by the physiological consequences of surgery such as pain. Nevertheless, delirium diagnosed at this early stage has been associated with adverse clinical outcomes. The last decade has seen the emergence of the confusion assessment method-intensive care unit (CAM-ICU) score as a quick practical method of detecting delirium in clinical situations...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29873010/a-review-of-chronic-musculoskeletal-pain-central-and-peripheral-effects-of-diclofenac
#17
REVIEW
Fabiola Atzeni, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini
Diclofenac is widely used to manage chronic inflammatory and degenerative joint diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, and extra-articular rheumatism. Its various mechanisms of action make it particularly effective in treating nociceptive pain, but it is also an alternative for treating spinal and chronic central pain. Osteoarthritis and rheumatoid arthritis are the most frequently encountered arthritic conditions in adults. The management of nociceptive pain requires a sequential hierarchical approach, with the initial NSAID treatment being characterized by the replacement of one drug with another, or complete discontinuation usually because of insufficient pain control...
June 5, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29872539/cryo-em-structure-of-the-asic1a-mambalgin-1-complex-reveals-that-the-peptide-toxin-mambalgin-1-inhibits-acid-sensing-ion-channels-through-an-unusual-allosteric-effect
#18
Demeng Sun, You Yu, Xiaobin Xue, Man Pan, Ming Wen, Siyu Li, Qian Qu, Xiaorun Li, Longhua Zhang, Xueming Li, Lei Liu, Maojun Yang, Changlin Tian
Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na+ channels that are activated by extracellular acidification. ASICs play essential roles in a wide range of physiological processes, including sodium homeostasis, synaptic plasticity, neurodegeneration, and sensory transduction. Mambalgins, a family of three-finger toxins isolated from black mamba venom, specifically inhibit ASICs to exert strong analgesic effects in vivo, thus are thought to have potential therapeutic values against pain...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29872383/from-the-bottom-up-chemotherapy-and-gut-brain-axis-dysregulation
#19
REVIEW
Juliana E Bajic, Ian N Johnston, Gordon S Howarth, Mark R Hutchinson
The central nervous system and gastrointestinal tract form the primary targets of chemotherapy-induced toxicities. Symptoms associated with damage to these regions have been clinically termed chemotherapy-induced cognitive impairment and mucositis. Whilst extensive literature outlines the complex etiology of each pathology, to date neither chemotherapy-induced side-effect has considered the potential impact of one on the pathogenesis of the other disorder. This is surprising considering the close bidirectional relationship shared between each organ; the gut-brain axis...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29872118/clinical-measurement-of-gastrointestinal-motility-and-function-who-when-and-which-test
#20
REVIEW
Mark R Fox, Peter J Kahrilas, Sabine Roman, C Prakash Gyawali, S Mark Scott, Satish S Rao, Jutta Keller, Michael Camilleri
Symptoms related to abnormal gastrointestinal motility and function are common. Oropharyngeal and oesophageal dysphagia, heartburn, bloating, abdominal pain and alterations in bowel habits are among the most frequent reasons for seeking medical attention from internists or general practitioners and are also common reasons for referral to gastroenterologists and colorectal surgeons. However, the nonspecific nature of gastrointestinal symptoms, the absence of a definitive diagnosis on routine investigations (such as endoscopy, radiology or blood tests) and the lack of specific treatments make disease management challenging...
June 5, 2018: Nature Reviews. Gastroenterology & Hepatology
keyword
keyword
114485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"