keyword
MENU ▼
Read by QxMD icon Read
search

GABA receptors

keyword
https://www.readbyqxmd.com/read/29223796/species-specific-rna-a-to-i-editing-of-mosquito-rdl-modulates-gaba-potency-and-influences-agonistic-potentiating-and-antagonistic-actions-of-ivermectin
#1
Jennina Taylor-Wells, Anish Senan, Isabel Bermudez, Andrew K Jones
The insect GABA receptor, RDL, is the target of several classes of pesticides. The peptide sequences of RDL are generally highly conserved between diverse insects. However, RNA A-to-I editing can effectively alter amino acid residues of RDL in a species specific manner, which can affect the potency of GABA and possibly insecticides. We report here that RNA A-to-I editing alters the gene products of Rdl in three mosquito disease vectors, recoding five amino acid residues in RDL of Aedes aegypti and six residues in RDLs of Anopheles gambiae and Culex pipiens, which is the highest extent of editing in RDL observed to date...
December 6, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29223397/-borneol-suppresses-conditioned-fear-recall-and-anxiety-like-behaviors-in-mice
#2
Bo Cao, Huan-Yu Ni, Jun Li, Ying Zhou, Xin-Lan Bian, Yan Tao, Cheng-Yun Cai, Cheng Qin, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29222949/a-switch-from-gaba-inhibition-to-excitation-of-vasopressin-neurons-exacerbates-the-development-angiotensin-ii-dependent-hypertension
#3
Aaron K Korpal, Su Young Han, Daryl O Schwenke, Colin H Brown
Hypothalamic magnocellular neurons secrete vasopressin into the systemic circulation to maintain blood pressure by increasing renal water reabsorption and by vasoconstriction. When blood pressure rises, baroreflex activation normally inhibits vasopressin neurons via activation of GABAergic inputs. However, plasma vasopressin levels are paradoxically elevated in several models of hypertension and in some patients with essential hypertension, despite increased blood pressure. We have previously shown that vasopressin neuron activity is increased early in the development of moderate angiotensin II-dependent hypertension via blunted baroreflex inhibition of vasopressin neurons...
December 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29218727/gabaa-and-gabab-receptor-subunit-localisation-on-neurochemically-identified-neurons-of-the-human-subthalamic-nucleus
#4
Xi Hua Wu, Jennifer Junru Song, Richard Lewis Maxwell Faull, Henry John Waldvogel
The subthalamic nucleus (STN) is a critical excitatory signalling centre within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signalling centres in the basal ganglia. In this study, we used immunohistochemical techniques to firstly, visualise and quantify the STN neurochemical organisation based on neuronal markers including parvalbumin (PV), calretinin (CR), SMI-32 and GAD65/67 . Secondly, we characterised the detailed regional, cellular and subcellular expression of GABAA (α1 , α2 , α3 , β2/3 and γ2 ) and GABAB (R1 and R2) receptor subunits within the normal human STN...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29217689/dopamine-dependent-sensitization-of-rod-bipolar-cells-by-gaba-is-conveyed-through-wide-field-amacrine-cells
#5
Amanda M Travis, Stephanie J Heflin, Arlene A Hirano, Nicholas C Brecha, Vadim Y Arshavsky
Vertebrate retina has the remarkable ability to support visual function under conditions of limited illumination, including processing signals evoked by single photons. Dim light vision is regulated by several adaptive mechanisms. The mechanism explored in this study is responsible for increasing the light sensitivity and operational range of rod bipolar cells, the retinal neurons operating immediately downstream of rod photoreceptors. This sensitization is achieved through the sustained dopamine-dependent GABA release from other retinal neurons...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29216460/getting-a-handle-on-neuropharmacology-by-targeting-receptor-associated-proteins
#6
REVIEW
Michael P Maher, Jose A Matta, Shenyan Gu, Mark Seierstad, David S Bredt
Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studies show that targeting a TARP auxiliary subunit of AMPA receptors selectively modulates neuronal excitability in specific forebrain pathways relevant to epilepsy. Other medicinally important ion channels, gated by glutamate, γ-aminobutyric acid (GABA), and acetylcholine, also have associated proteins, which may be druggable...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29216332/voltage-dependent-calcium-channel-signaling-mediates-gabaa-receptor-induced-migratory-activation-of-dendritic-cells-infected-by-toxoplasma-gondii
#7
Sachie Kanatani, Jonas M Fuks, Einar B Olafsson, Linda Westermark, Benedict Chambers, Manuel Varas-Godoy, Per Uhlén, Antonio Barragan
The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ-aminobutyric acid (GABA)/GABAA receptor signaling triggers a hypermigratory phenotype in dendritic cells (DCs) by unknown signal transduction pathways. Here, we demonstrate that calcium (Ca2+) signaling in DCs is indispensable for T. gondii-induced DC hypermotility and transmigration in vitro. We report that activation of GABAA receptors by GABA induces transient Ca2+ entry in DCs...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29212793/pacap-6-38-or-kynurenate-microinjections-into-the-rvlm-prevent-development-of-sympathetic-long-term-facilitation-following-acute-intermittent-hypoxia
#8
Zohra M Kakall, Paul M Pilowsky, Melissa Mj Farnham
BACKGROUND AND PURPOSE: Intermittent hypoxia causes a persistent increase in sympathetic activity, which progresses to hypertension in chronic conditions such as obstructive sleep apnea (OSA). Pituitary adenylate cyclase activating polypeptide (PACAP) is an excitatory neurotransmitter that causes long-lasting sympathetic excitation. We aimed to determine if intermittent activation of the rostral ventrolateral medulla (RVLM) causes PACAP-mediated elevation of sympathetic nerve activity (sSNA), termed sympathetic long-term facilitation (sLTF)...
December 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29209452/protective-roles-of-hepatic-gaba-signaling-in-liver-injury
#9
Shuanglian Wang, Lu Zhang, Chuanyong Liu, Wei-Yang Lu
In addition to functioning as a neurotransmitter, γ-aminobutyric acid (GABA) generates signals, via its type A or type B receptors (GABAARs or GABABRs), in various types of cells. Studies, including ours, show that GABAAR-mediated auto- and paracrine GABAergic signaling occurs in rodent hepatocytes and cholangiocytes, protecting the liver against toxic injuries. This short article briefly introduces the GABA signaling system in rodent livers and discusses potential mechanisms by which the hepatic GABA signaling protects the liver function...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209205/potentiation-of-morphine-induced-antinociception-by-propranolol-the-involvement-of-dopamine-and-gaba-systems
#10
Elham A Afify, Najlaa M Andijani
Tolerance to the analgesic effect of morphine is a major clinical problem which can be managed by co-administration of another drug. This study investigated the ability of propranolol to potentiate the antinociceptive action of morphine and the possible mechanisms underlying this effect. Antinociception was assessed in three nociceptive tests (thermal, hot plate), (visceral, acetic acid), and (inflammatory, formalin test) in mice and quantified by measuring the percent maximum possible effect, the percent inhibition of acetic acid-evoked writhing response, and the area under the curve values of number of flinches for treated mice, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29206482/brain-circuits-and-neurochemical-systems-in-essential-tremor-insights-into-current-and-future-pharmacotherapeutic-approaches
#11
Sara M Schaefer, Ana Vives Rodriguez, Elan D Louis
There are few medications that are available for the treatment of essential tremor (ET) and they are only moderately effective. Areas covered: Data were obtained from a PubMed search. Original articles, review articles, and clinical guidelines were included. Two disease models for ET have been proposed: 1) the olivary model, which attributes ET to a pathological pacemaker in the inferior olivary nucleus, and 2) the cerebellar degeneration model, which postulates that ET originates in the cerebellum and could be related to deficient or abnormal Purkinje cell (PC) output...
December 5, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29206245/correction-liu-et-al-dynamics-of-gnrh-neuron-ionotropic-gaba-and-glutamate-synaptic-receptors-are-unchanged-during-estrogen-positive-and-negative-feedback-in-female-mice-eneuro-september-october-2017-4-5-e0259-17-2017-1-14-http-dx-doi-org-10-1523-eneuro-0259
#12
https://www.readbyqxmd.com/read/29204713/gabaa-receptor-subtype-mechanisms-and-the-abuse-related-effects-of-ethanol-genetic-and-pharmacological-evidence
#13
Cassie M Chandler, John S Overton, Daniela Rüedi-Bettschen, Donna M Platt
Ethanol's reinforcing and subjective effects, as well as its ability to induce relapse, are powerful factors contributing to its widespread use and abuse. A significant mediator of these behavioral effects is the GABAA receptor system. GABAA receptors are the target for γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the CNS. Structurally, they are pentameric, transmembrane chloride ion channels comprised of subunits from at least eight different families of distinct proteins. The contribution of different GABAA subunits to ethanol's diverse abuse-related effects is not clear and remains an area of research focus...
December 5, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29204712/presynaptic-ethanol-actions-potential-roles-in-ethanol-seeking
#14
David M Lovinger
Ethanol produces intoxication through actions on numerous molecular and cellular targets. Adaptations involving these and other targets contribute to chronic drug actions that underlie continued and problematic drinking. Among the mechanisms involved in these ethanol actions are alterations in presynaptic mechanisms of synaptic transmission, including presynaptic protein function and excitation-secretion coupling. At synapses in the central nervous system (CNS), excitation-secretion coupling involves ion channel activation followed by vesicle fusion and neurotransmitter release...
December 5, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29204059/potential-rat-model-of-anxiety-like-gastric-hypersensitivity-induced-by-sequential-stress
#15
Fu-Chun Jing, Jun Zhang, Chen Feng, Yuan-Yuan Nian, Jin-Hai Wang, Hao Hu, Bao-De Yang, Xiao-Ming Sun, Jian-Yun Zheng, Xiao-Ran Yin
AIM: To establish a rat model of anxiety-like gastric hypersensitivity (GHS) of functional dyspepsia (FD) induced by novel sequential stress. METHODS: Animal pups were divided into two groups from postnatal day 2: controls and the sequential-stress-treated. The sequential-stress-treated group received maternal separation and acute gastric irritation early in life and restraint stress in adulthood; controls were reared undisturbed with their mothers. Rats in both groups were followed to adulthood (8 wk) at which point the anxiety-like behaviors and visceromotor responses to gastric distention (20-100 mmHg) and gastric emptying were tested...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203576/dimethoxy-etomidate-a-non-hypnotic-etomidate-analog-that-potently-inhibits-steroidogenesis
#16
Megan McGrath, Celena Ma, Douglas Raines
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is among the most potent inhibitors of adrenocortical steroidogenesis. However, its use as a treatment for Cushing's syndrome is complicated by its sedative-hypnotic activity and ability to produce myoclonus, central nervous system actions thought to be mediated by the GABAA receptor...
December 4, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29203179/neurotransmitters-in-the-mediation-of-cerebral-ischemic-injury
#17
REVIEW
Diana Mayor, Michael Tymianski
Under physiological conditions, neurotransmitters shape neuronal networks and control several cellular and synaptic functions. In the mammalian central nervous system (CNS), excitatory and inhibitory neurotransmission are mediated in large part by Glutamate and gamma-aminobutyric acid (GABA), which are excitatory and inhibitory neurotransmitters, respectively. Glutamate and GABA also play crucial roles in neurological disorders such as cerebral ischemia. Glutamate in particular causes excitotoxicity, known as one of the hallmark mechanisms in the pathophysiology of cerebral ischemic injury for more than thirty years...
December 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29202749/inhibitory-or-excitatory-optogenetic-interrogation-of-the-functional-roles-of-gabaergic-interneurons-in-epileptogenesis
#18
REVIEW
Hui Ye, Stephanie Kaszuba
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits hyperactivity in the epileptic circuitry. As a consequence, optogenetic excitation of GABAergic interneurons is widely used for seizure suppression. However, recent evidence argues for the context-dependent, possibly "excitatory" roles that GABAergic cells play in epileptic circuitry...
December 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29200913/developmental-changes-in-gabaa-tonic-inhibition-are-compromised-by-multiple-mechanisms-in-preadolescent-dentate-gyrus-granule-cells
#19
Sudip Pandit, Gyu Seung Lee, Jin Bong Park
The sustained tonic currents (Itonic) generated by γ-aminobutyric acid A receptors (GABAARs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating Itonic in the hippocampus are known, their combined role in Itonic regulation is not well understood in different age groups. In this study, we demonstrated that a developmental increase in GABA transporter (GAT) expression, combined with gradual decrease in GABAAR α5 subunit, resulted in various Itonic in the dentate gyrus granule cells (DGGCs) of preadolescent rats...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29196217/huntington-s-disease-leads-to-decrease-of-gaba-a-tonic-subunits-in-the-d2-neostriatal-pathway-and-their-relocalization-into-the-synaptic-cleft
#20
Abraham Rosas-Arellano, Carlos Tejeda-Guzmán, Enrique Lorca-Ponce, Lourdes Palma-Tirado, Carola A Mantellero, Patricio Rojas, Fanis Missirlis, Maite A Castro
GABA is a widely distributed inhibitory neurotransmitter. GABA-A receptors are hetero-pentameric channels assembled in multiple combinations from 19 available subunits; this diversity mediates phasic and tonic inhibitory synaptic potentials. Whereas GABA-A phasic receptors are located within the synaptic cleft, GABA-A tonic receptors are found peri- or extra-synaptically, where they are activated by diffusion of synaptic GABA release. In the neostriatum, GABA-A tonic subunits are present in the D2 medium-size spiny neurons...
November 28, 2017: Neurobiology of Disease
keyword
keyword
11448
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"