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https://www.readbyqxmd.com/read/28527713/stability-or-instability-in-avoidant-personality-disorder-mode-fluctuations-within-schema-therapy-sessions
#1
Ofer Peled, Eran Bar-Kalifa, Eshkol Rafaeli
BACKGROUND AND OBJECTIVES: Avoidant personality disorder (APD) is among the most prevalent personality disorders, but has received relatively little empirical attention. This study aims to characterize the frequency, intensity, and fluctuation patterns seen in the modes (self-states) of APD clients over the course of schema therapy (ST), a psychotherapy approach developed especially for personality disorders. METHOD: The newly-developed client mode rating scale (CMRS) was used to code every 5-min segment (n = 645) of 60 ST sessions...
May 6, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28526073/pulse-wave-velocity-and-cardiac-autonomic-function-in-type-2-diabetes-mellitus
#2
Stamatina Chorepsima, Ioanna Eleftheriadou, Anastasios Tentolouris, Ioannis Moyssakis, Athanasios Protogerou, Alexandros Kokkinos, Petros P Sfikakis, Nikolaos Tentolouris
BACKGROUND: Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication of diabetes and has been associated with reduced aortic distensibility. However, the association of cardiac autonomic dysfunction with PWV is not known. In this study we examined the association between cardiac autonomic function and PWV in subjects with type 2 diabetes mellitus...
May 19, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28521764/barrier-dysfunction-or-drainage-reduction-differentiating-causes-of-csf-protein-increase
#3
Mahdi Asgari, Diane A de Zélicourt, Vartan Kurtcuoglu
BACKGROUND: Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured protein levels, the Reiber diagram is particularly robust with respect to physiologic inter-individual variability, as it uses multiple subject-specific anchoring values. Beyond reliable identification of abnormal protein levels, the Reiber diagram has the potential to elucidate their pathophysiologic origin...
May 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28515855/speckle-tracking-echocardiography-to-assess-regional-ventricular-function-in-patients-with-apical-hypertrophic-cardiomyopathy
#4
María Cristina Saccheri, Tomás Francisco Cianciulli, Luis Alberto Morita, Ricardo José Méndez, Martín Alejandro Beck, Juan Enrique Guerra, Alberto Cozzarin, Luciana Jimena Puente, Lorena Romina Balletti, Jorge Alberto Lax
AIM: To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy (HCM). METHODS: We prospectively assessed 20 patients (mean age 53 ± 16 years, range: 18-81 years, 10 were male), with apical HCM. We measured global longitudinal peak systolic strain (GLPSS) in the midwall and endocardium of the left ventricle. RESULTS: The diastolic thickness of the 4 apical segments was 16...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28515695/chronic-endurance-exercise-impairs-cardiac-structure-and-function-in-middle-aged-mice-with-impaired-nrf2-signaling
#5
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P Mason, Ramalingam Sankaran, John R Hoidal, Namakkal S Rajasekaran
Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation. Earlier we reported that acute endurance exercise (2 days) evoked antioxidant cytoprotection in young WT animals but not in aged WT animals. However, the effect of repeated endurance exercise during biologic aging (WT) characterized by an inherent deterioration in Nrf2 signaling and pathological aging (pronounced oxidative susceptibility-Nrf2 absence) in the myocardium remains elusive...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28514956/transcriptome-analysis-for-the-identification-of-cellular-markers-related-to-trabecular-meshwork-differentiation
#6
Padmapriya Sathiyanathan, Cheryl Y Tay, Lawrence W Stanton
BACKGROUND: Development of primary open-angle glaucoma (POAG) is associated with the malfunctioning trabecular meshwork (TM). Cell therapy offers great potential for the treatment of POAG, but requires the generation of functional TM cells in vitro to replace the lost/dysfunctional cells. TM differentiation in vitro from various stem cell types must be monitored by the expression of specific markers. However, no single definitive marker of the TM has been identified. RESULTS: To identify robust markers of TM differentiation, we performed global transcriptome profiling using high-density oligonucleotide microarray on ex vivo TM tissue and cultured TM progenitors...
May 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28511578/retinal-atrophy-in-relation-to-visual-functioning-and-vision-related-quality-of-life-in-patients-with-multiple-sclerosis
#7
Lisanne J Balk, Danko Coric, Jenny A Nij Bijvank, Joep Killestein, Bernard Mj Uitdehaag, Axel Petzold
BACKGROUND: Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. OBJECTIVE: To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON). METHODS: Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28509120/complex-glomerular-pathology-of-thrombotic-microangiopathy-and-focal-segmental-glomerulosclerosis-forms-tumor-like-mass-in-a-renal-transplant-donor-with-severe-renovascular-hypertension
#8
Michio Nagata, Yutaka Yamaguchi, Daisuke Toki, Izumi Yamamoto, Hiroaki Shinmura, Hiroshi Kawaguchi
The pathogenesis of glomerular hypertension-mediated FSGS and its histological variations in humans remains unknown. A 47-year-old man developed nephrotic syndrome, renal dysfunction, and malignant hypertension 2 years after donating a kidney to his son. The donor's remnant kidney developed renal mass at an upper pole which was fed by an aberrant artery that branched from the root of the renal artery. Furthermore, the main non-aberrant renal artery demonstrated severe stenosis that caused renovascular hypertension, resulting in malignant hypertension...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28509077/relationships-between-cognitive-impairment-on-adas-cog-and-regional-cerebral-blood-flow-using-spect-in-late-onset-alzheimer-s-disease
#9
Michio Takahashi, Yasunori Oda, Toshiyuki Okubo, Yukihiko Shirayama
The aim of this study was to examine brain hypoperfusion and its relationship with cognitive dysfunction in late-onset Alzheimer's disease (AD). Forty patients with late-onset AD and not receiving acetylcholinesterase inhibitors were recruited from outpatient clinics. We examined cognitive function using the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and brain perfusion using single-photon emission computed tomography, and analyzed classified gyrus level segments with three-dimensional stereotactic surface projection and the stereotactic extraction estimation method level 3...
May 16, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28506549/impact-of-chronic-obstructive-pulmonary-disease-on-in-hospital-morbidity-and-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#10
Răzvan Constantin Șerban, Laszlo Hadadi, Ioana Șuș, Eva Katalin Lakatos, Zoltan Demjen, Alina Scridon
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) presenting with ST-segment elevation myocardial infarction (STEMI) are less likely to beneficiate of primary percutaneous coronary intervention (pPCI), and have poorer prognosis. We aimed to evaluate the impact of COPD on the in-hospital outcomes of pPCI-treated STEMI patients. METHODS: Data were collected from 418 STEMI patients treated by pPCI. Inotropics and diuretics usage, cardiogenic shock, asystole, kidney dysfunction, and left ventricular ejection fraction were used as markers of hemodynamic complications...
May 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28497844/echocardiographic-evaluation-of-right-ventricular-systolic-function-the-traditional-and-innovative-approach
#11
Dorota Smolarek, Marcin Gruchała, Wojciech Sobiczewski
Estimation of right ventricular (RV) performance still remains technically challenging due to its anatomical and functional distinctiveness. The current guidelines for the echocardiographic quantification of RV function recommend using multiple indices to describe the RV in a thorough and comprehensive manner, such as RV index of myocardial performance, tricuspid annular plane systolic excursion, fractional area change, Doppler tissue imaging-derived tricuspid lateral annular systolic velocity (S'-wave), three-dimensional RV ejection fraction (3D RVEF), longitudinal strain (RVLS)/strain rate by speckle-tracking echocardiography (STE)...
May 12, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28489693/dysfunctional-autonomic-regulation-of-the-choroid-in-central-serous-chorioretinopathy
#12
C Nathaniel Roybal, Elisabeth Sledz, Yasser Elshatory, Li Zhang, David R P Almeida, Eric K Chin, Brice Critser, Michael D Abramoff, Stephen R Russell
PURPOSE: To study the effect of changing perfusion pressures on retinal and choroidal structure in central serous chorioretinopathy (CSC). METHODS: This prospective observational case series included seven healthy volunteers (14 eyes) and seven patients (14 eyes) with CSC. Each patient underwent spectral domain optical coherence tomography with enhanced depth imaging in the upright (sitting) and supine positions. Image segmentation focused on central macular thickness, subretinal fluid, total macular volume, choroidal thickness, and choriocapillaris thickness...
May 9, 2017: Retina
https://www.readbyqxmd.com/read/28489211/endovascular-treatment-of-carotid-cavernous-vascular-lesions
#13
Guilherme Brasileiro DE Aguiar, João Miguel Silva, Aline Lariessy Paiva, Maurício Jory, Mario Luiz Conti, José Carlos Veiga
Objective: to evaluate the endovascular treatment of vascular lesions of the cavernous segment of the internal carotidartery (ICA) performed at our institution. Methods: we conducted a descriptive, retrospective and prospective study of patients with aneurysms of the cavernous portion of the ICA or with direct carotid-cavernous fistulas (dCCF) undergoing endovascular treatment. Results: we included 26 patients with intracavernous aneurysms and ten with dCCF...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28487114/structural-brain-network-analysis-of-children-with-localization-related-epilepsy
#14
Kanako Takeda, Hiroshi Matsuda, Yusaku Miyamoto, Hitoshi Yamamoto
INTRODUCTION: Epilepsy is considered to arise from dysfunction in neural networks. Recent advances in neuroimaging and its analysis have made it possible to investigate both functional and structural connectivity in the brain. The aim of this study was to elucidate alterations in the structural connectivity in children with localization-related epilepsy using the mathematical method of graph theoretical analysis. METHODOLOGY: Fifteen children with localization-related epilepsy (8 female subjects; mean age, 8...
May 6, 2017: Brain & Development
https://www.readbyqxmd.com/read/28476663/a-probabilistic-template-of-human-mesopontine-tegmental-nuclei-from-in-vivo-7-t-mri
#15
REVIEW
Marta Bianciardi, Christian Strong, Nicola Toschi, Brian L Edlow, Bruce Fischl, Emery N Brown, Bruce R Rosen, Lawrence L Wald
Mesopontine tegmental nuclei such as the cuneiform, pedunculotegmental, oral pontine reticular, paramedian raphe and caudal linear raphe nuclei, are deep brain structures involved in arousal and motor function. Dysfunction of these nuclei is implicated in the pathogenesis of disorders of consciousness and sleep, as well as in neurodegenerative diseases. However, their localization in conventional neuroimages of living humans is difficult due to limited image sensitivity and contrast, and a stereotaxic probabilistic neuroimaging template of these nuclei in humans does not exist...
May 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28476557/podocytes-regulate-the-glomerular-basement-membrane-protein-nephronectin-by-means-of-mir-378a-3p-in-glomerular-diseases
#16
Janina Müller-Deile, Jan Dannenberg, Patricia Schroder, Meei-Hua Lin, Jeffrey H Miner, Rongjun Chen, Jan-Hinrich Bräsen, Thomas Thum, Jenny Nyström, Lynne Beverly Staggs, Hermann Haller, Jan Fiedler, Johan M Lorenzen, Mario Schiffer
The pathophysiology of many proteinuric kidney diseases is poorly understood, and microRNAs (miRs) regulation of these diseases has been largely unexplored. Here, we tested whether miR-378a-3p is a novel regulator of glomerular diseases. MiR-378a-3p has two predicted targets relevant to glomerular function, the glomerular basement membrane matrix component, nephronectin (NPNT), and vascular endothelial growth factor VEGF-A. In zebrafish (Danio rerio), miR-378a-3p mimic injection or npnt knockdown by a morpholino oligomer caused an identical phenotype consisting of edema, proteinuria, podocyte effacement, and widening of the glomerular basement membrane in the lamina rara interna...
May 2, 2017: Kidney International
https://www.readbyqxmd.com/read/28475715/reep6-deficiency-leads-to-retinal-degeneration-through-disruption-of-er-homeostasis-and-protein-trafficking
#17
Smriti A Agrawal, Thomas Burgoyne, Aiden Eblimit, James Bellingham, David A Parfitt, Amelia Lane, Ralph Nichols, Chinwe Asomugha, Matthew J Hayes, Peter M Munro, Mingchu Xu, Keqing Wang, Clare E Futter, Yumei Li, Rui Chen, Michael E Cheetham
Retinitis pigmentosa (RP) is the most common form of inherited retinal dystrophy. We recently identified mutations in REEP6, which encodes the receptor expression enhancing protein 6, in several families with autosomal recessive RP. REEP6 is related to the REEP and Yop1p family of ER shaping proteins and potential receptor accessory proteins, but the role of REEP6 in the retina is unknown. Here we characterise the disease mechanisms associated with loss of REEP6 function using a Reep6 knockout mouse generated by CRISPR/Cas9 gene editing...
May 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28471536/assessment-of-subtle-cardiac-dysfunction-in-patients-with-frequent-premature-ventricular-complexes-by-real-time-three-dimensional-speckle-tracking-echocardiography
#18
Yunlong Ling, Quan Wan, Qingxing Chen, Wenqing Zhu
BACKGROUND: To evaluate subtle and early premature ventricular complex (PVC)-induced ventricular impairment in patients with frequent PVCs and without structural heart disease by real-time 3-dimensional (3D) speckle tracking echocardiography (RT3D-STE). HYPOTHESIS: Patients with frequent premature ventricular complexes with normal left ventricular ejection fraction have subtle left ventricular dysfunction. METHODS: Forty patients (22 male) with a single source of frequent PVCs and 40 healthy controls (24 male) underwent assessment by conventional 2-dimensional (2D) echocardiography and RT3D-STE...
May 4, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28465785/endoscopic-balloon-catheter-dilatation-via-retrograde-or-static-technique-is-safe-and-effective-for-cricopharyngeal-dysfunction
#19
Vinay Chandrasekhara, Joyce Koh, Lakshmi Lattimer, Kerry B Dunbar, William J Ravich, John O Clarke
AIM: To evaluate the safety and efficacy of upper esophageal sphincter (UES) dilatation for cricopharyngeal (CP) dysfunction. To determine if: (1) indication for dilatation; or (2) technique of dilatation correlated with symptom improvement. METHODS: All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success...
April 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28463835/neurodegeneration-and-the-cerebellum
#20
Margot Samson, Daniel O Claassen
BACKGROUND: The cerebellum modulates diverse neuronal networks, regulating motor, cognitive, behavioral, and limbic circuits. Structural and functional changes to the cerebellum that occur with neurodegenerative conditions have not been systematically reviewed. OBJECTIVE: We synthesize the current understanding of cerebellar somatotopy and function with previously described cerebellar changes in neurodegenerative diseases not associated with primary cerebellar pathology...
May 3, 2017: Neuro-degenerative Diseases
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