keyword
MENU ▼
Read by QxMD icon Read
search

Segmental dysfunction

keyword
https://www.readbyqxmd.com/read/29334505/the-association-of-chronic-air-pollutants-with-coronary-artery-spasm-vasospastic-angina-and-endothelial-dysfunction
#1
Byoung Geol Choi, Jiwon Lee, Suhng Wook Kim, Min Woo Lee, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND: We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. PATIENTS AND METHODS: A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www...
January 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29328453/aldosterone-is-involved-in-the-pathogenesis-of-obesity-related-glomerulopathy-through-activation-of-wnt-%C3%AE-catenin-signaling-in-podocytes
#2
Jia-Jia Zhu, Yi-Pu Chen, Min Yang, Bao-Li Liu, Jing Dong, Hong-Rui Dong, Hong-Liang Rui, Hong Cheng
Obesity-related glomerulopathy (ORG) is morphologically characterized by glomerulomegaly with or without observable focal segmental glomerulosclerosis under light microscope, with decreased podocyte density and number, and with increased foot‑process width observed under electron microscope. The severity of podocyte injury is correlated with the degree of proteinuria and renal dysfunction. However, the pathogenesis of ORG is not well understood. The aim of the present study was to explore the possible pathogenic role of aldosterone (ALDO) in ORG...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325384/-diagnosis-and-treatment-of-strabismus-caused-by-nasal-endoscopic-surgery
#3
L K Ai, X Wu, J N Wang, J Li, Y Wu, J Zhou, W X Song, R L Guo
Objective: Strabismus with diplopia is the main orbital complication of functional endoscopic sinus surgery (FESS). This study was to analyze clinical findings, treatment and outcomes of such cases. Methods: Retrospective case series. Twenty-three cases were divided into 3 groups based on the disease severity: group A, partial transection of the medial rectus muscle, group B, complete transection of the medical rectus, group C, transection of the medial rectus combined with the other orbital injuries. Complete ophthalmology examinations, including eye alignment, eye motility, force duction test, force generation test, general eye exam, and medical imaging (orbital CT or MRI), were performed for each case...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29314212/lumbar-to-sacral-root-rerouting-to-restore-bladder-function-in-a-feline-spinal-cord-injury-model-urodynamic-and-retrograde-nerve-tracing-results-from-a-pilot-study
#4
Ornella Lam Van Ba, Mary F Barbe, Romain Caremel, Shachar Aharony, Oleg Loutochin, Line Jacques, Matthew W Wood, Ekta Tiwari, Gerald F Tuite, Lysanne Campeau, Jacques Corcos, Michael R Ruggieri
AIMS: Lumbar to sacral rerouting surgery can potentially allow voiding via a skin-central nervous system-bladder reflex pathway. Here, we assessed if this surgery was effective in treating neurogenic bladder dysfunction/sphincter in felines. METHODS: Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Unilateral L7 to S1 ventral root anastomosis was performed 1 month later in six cats. Two cats served as transection-only controls. Electrical and manual stimulation of L6-S1 dermatomes, and urodynamics were performed at 3, 5, 7, and 9/10 months post transection...
January 4, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29313878/postpartum-ct-angiography-of-the-fetoplacental-macrovasculature-in-normal-pregnancies-and-in-those-complicated-by-fetal-growth-restriction
#5
Mette Østergaard Thunbo, Marianne Sinding, Anne Sofie Korsager, Jens Brøndum Frøkjaer, Lasse Riis Østergaard, Astrid Petersen, Charlotte Overgaard, Anne Sørensen
INTRODUCTION: Current knowledge of the fetoplacental vasculature in fetal growth restriction (FGR) due to placental dysfunction focuses on the microvasculature rather than the macrovasculature. The aim of this study was to investigate the feasibility of computed topography angiography to analyze the fetoplacental macrovasculature in normal and FGR pregnancies. MATERIAL AND METHODS: We included 29 placentas (22-42 weeks' gestation) from normal birthweight pregnancies and 8 placentas (26-37 weeks' gestation) from FGR pregnancies (birthweight < -15% and abnormal umbilical Doppler flow)...
January 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29305703/cardiac-ischemia-insights-from-computational-models
#6
REVIEW
Axel Loewe, Eike Moritz Wülfers, Gunnar Seemann
BACKGROUND: Complementary to clinical and experimental studies, computational cardiac modeling serves to obtain a comprehensive understanding of the cardiovascular system in order to analyze dysfunction, evaluate existing, and develop novel treatment strategies. OBJECTIVES: We describe the basics of multiscale computational modeling of cardiac electrophysiology from the molecular ion channel to the whole body scale. By modeling cardiac ischemia, we illustrate how in silico experiments can contribute to our understanding of how the pathophysiological mechanisms translate into changes observed in diagnostic tools such as the electrocardiogram (ECG)...
January 5, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29302938/long-term-results-of-aortic-root-surgery-in-marfan-syndrome-patients-a-single-center-experience
#7
Francesco Nicolo, Francesco Romeo, Antonio Lio, Emanuele Bovio, Antonio Scafuri, Carlo Bassano, Patrizio Polisca, Antonio Pellegrino, Paolo Nardi, Luigi Chiariello, Giovanni Ruvolo
BACKGROUND: The study aim was to compare long-term results of Marfan syndrome (MFS) patients affected by aortic root disease undergoing aortic root replacement with the Bentall or David operation. METHODS: Since 1994, a total of 59 patients has been followed at the authors' Marfan Center, having undergone either a Bentall operation (Bentall group, n = 30) or a David operation (David group, n = 29). RESULTS: No operative mortality was recorded...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29302903/pelvi-ureteric-junction-obstruction-related-to-crossing-vessels-vascular-anatomic-variations-and-implication-for-surgical-approaches
#8
REVIEW
Frédéric Panthier, Fabien Lareyre, Marie Audouin, Juliette Raffort
Pelvi-ureteric junction obstruction corresponds to an impairment of urinary transport that can lead to renal dysfunction if not treated. Several mechanisms can cause the obstruction of the ureter including intrinsic factors or extrinsic factors such as the presence of crossing vessels. The treatment of the disease relies on surgical approaches, pyeloplasty being the standard reference. The technique consists in removing the pathologic ureteric segment and renal pelvis and transposing associated crossing vessels if present...
January 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29279420/deregulated-profiles-of-urinary-micrornas-may-explain-podocyte-injury-and-proximal-tubule-dysfunction-in-normoalbuminuric-patients-with-type-2-diabetes-mellitus
#9
Oana Milas, Florica Gadalean, Adrian Vlad, Victor Dumitrascu, Cristina Gluhovschi, Gheorghe Gluhovschi, Silvia Velciov, Roxana Popescu, Flaviu Bob, Petru Matusz, Agneta-Maria Pusztai, Octavian M Cretu, Alina Secara, Anca Simulescu, Sorin Ursoniu, Daliborca Vlad, Ligia Petrica
MicroRNAs (miRNAs) are short non-coding RNA species that are important post-transcriptional regulators of gene expression. The aim of the study was to establish a potential explanation of podocyte damage and proximal tubule (PT) dysfunction induced by deregulated miRNAs expression in the course of type 2 diabetes mellitus (DM). A total of 68 patients with type 2 DM and 11 healthy subjects were enrolled in a cross-sectional study and assessed concerning urinary albumin:creatinine ratio (UACR), urinary N-acetyl-β-D-glucosamininidase (NAG), urinary kidney injury molecule-1, urinary nephrin, podocalyxin, synaptopodin, estimated glomerular filtration rate (eGFR), urinary miRNA21, miRNA124, and miRNA192...
December 25, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29259860/steroid-resistant-nephrotic-syndrome-caused-by-co-inheritance-of-mutations-at-nphs1-and-adck4-genes-in-two-chinese-siblings
#10
Hongwen Zhang, Fang Wang, Xiaoyu Liu, Xuhui Zhong, Yong Yao, Huijie Xiao
Hereditary nephrotic syndrome often presents with steroid-resistance and onset within the first year of life. Mutations in genes highly expressed in podocytes have been found in two thirds of these patients, especially NPHS1 and NPHS2 among at least 29 genetic causes that have been discovered. We reported two siblings with steroid-resistant nephrotic syndrome caused by co-inheritance of mutations at NPHS1 (c.1339G>A, p.E447K) and ACDK4 (c.748G>C, p.D250H) genes. The siblings presented with steroid-resistant nephrotic syndrome and pathological lesions of focal segmental glomerulosclerosis (FSGS), while the elder sister also developed hypertension, renal failure and cardiac dysfunction...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29249245/relationship-between-sleep-disordered-breathing-and-renal-dysfunction-in-acute-coronary-syndrome
#11
Masayoshi Kiyokuni, Chika Kawashima, Masaaki Konishi, Kentaro Sakamaki, Kiwamu Iwata, Naoki Nakayama, Naohiro Komura, Masami Kosuge, Teruyasu Sugano, Tomoaki Ishigami, Tsutomu Endo, Toshiyuki Ishikawa, Takeharu Yamanaka, Kazuo Kimura, Kouichi Tamura
BACKGROUND: Sleep-disordered breathing (SDB) is associated with cardiovascular complications. However, the effect of SDB on renal function in patients with acute coronary syndrome (ACS) treated by percutaneous coronary intervention (PCI) remains unclear. METHODS: We enrolled 154 consecutive ACS patients without heart failure. A sleep study was performed immediately after PCI. RESULTS: The mean apnea-hypopnea index (AHI) was 16.4±13.1, and 33 patients (21%) had severe SDB, defined as AHI≥25...
February 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29249183/aav-gene-delivery-to-the-spinal-cord-serotypes-methods-candidate-diseases-and-clinical-trials
#12
Nathan Hardcastle, Nicholas M Boulis, Thais Federici
Adeno-associated viral (AAV) vector-mediated gene delivery to the spinal cord has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using AAV gene therapy for pediatric disorders - spinal muscular atrophy (SMA) and giant axonal neuropathy (GAN) - are now underway. Areas covered: This review addresses the latest progress in the field of AAV gene delivery to the spinal cord, particularly focusing on the most prominent AAV serotypes and delivery methodologies to the spinal cord. Candidate diseases and scaling up experiments in large animals are also discussed...
December 18, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29244747/ophthalmic-formulation-containing-nilvadipine-nanoparticles-prevents-retinal-dysfunction-in-rats-injected-with-streptozotocin
#13
Saori Deguchi, Hiroko Otake, Yosuke Nakazawa, Noriko Hiramatsu, Naoki Yamamoto, Noriaki Nagai
Retinopathy leads to irreparable vision loss via capillary closure and areas of nonperfusion. However, the current instillation systems do not allow a sufficient amount of drug required to treat retinopathy to reach the posterior segment (retina); therefore, a new formulation targeting the posterior segment is expected as therapy for retinopathy. We prepared ophthalmic formulations containing nilvadipine nanoparticles (NILnano), and demonstrated whether the instillation of NILnano can prevent retinal dysfunction in rats injected with excessive streptozotocin (STZ rats) in this study...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240955/pine-wilt-disease-causes-cavitation-around-the-resin-canals-and-irrecoverable-xylem-conduit-dysfunction
#14
Kenichi Yazaki, Takuma Takanashi, Natsumi Kanzaki, Masabumi Komatsu, Delphis F Levia, Daisuke Kabeya, Hiroyuki Tobita, Mitsutoshi Kitao, Atsushi Ishida
Physiological mechanisms of irreversible hydraulic dysfunction in seedlings infected with pine wilt disease (PWD) are still unclear. We employed cryo-scanning electron microscopy (cryo-SEM) to investigate the temporal and spatial changes in water distribution within the xylem of the main stem of 2-year-old Japanese black pine seedlings infested by pine wood nematodes (PWNs). Our experiment was specifically designed to compare the water relations among seedlings subjected to the following water treatment and PWN combinations: (i) well-watered versus prolonged drought (no PWNs); and (ii) well-watered with PWNs versus water-stressed with PWNs (four treatments in total)...
December 12, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29237925/corneal-endothelial-cell-loss-in-femtosecond-laser-assisted-descemet-s-stripping-automated-endothelial-keratoplasty-a-12-month-follow-up-study
#15
Yun Feng, Hong-Qiang Qu, Jing Ren, Philipp Prahs, Jing Hong
BACKGROUND: Descemet's stripping automated endothelial keratoplasty (DSAEK) surgery offers a more standardized approach and reliable method to create corneal grafts with an instrument such as a microkeratome. With the development of Descemet's membrane endothelial keratoplasty, an excellent clinical outcome is seen in the treatment of corneal endothelial dysfunctions, which indicates that thinner corneal graft results in better clinical outcome. With the recent development of the femtosecond laser, ultrathin corneal graft preparation has become possible...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29233648/left-atrial-dysfunction-in-light-chain-cardiac-amyloidosis-and-hypertrophic-cardiomyopathy-a-comparative-three-dimensional-speckle-tracking-echocardiographic-analysis-from-the-magyar-path-study
#16
Dóra Földeák, Árpád Kormányos, Péter Domsik, Anita Kalapos, Györgyike Á Piros, Nóra Ambrus, Zénó Ajtay, Róbert Sepp, Zita Borbényi, Tamás Forster, Attila Nemes
INTRODUCTION: While cardiac amyloidosis (CA) is a rare systemic disease characterized by extracellular deposition of protein-derived fibrils, hypertrophic cardiomyopathy (HCM) is histopathologically characterized by myocyte hypertrophy and disarray, interstitial fibrosis, and small intramural coronary arteriole dysplasia. The aim of the present study was to compare left atrial (LA) volumetric and functional characteristics between light-chain (AL) CA and HCM by three-dimensional (3D) speckle-tracking echocardiography (STE)...
December 9, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29228911/intrapartum-factors-associated-with-neonatal-hypoxic-ischemic-encephalopathy-a-case-controlled-study
#17
Vanessa E Torbenson, Mary Catherine Tolcher, Kate M Nesbitt, Christopher E Colby, Sherif A El-Nashar, Bobbie S Gostout, Amy L Weaver, Michaela E Mc Gree, Abimbola O Famuyide
BACKGROUND: Neonatal encephalopathy (NE) affects 2-4/1000 live births with outcomes ranging from negligible neurological deficits to severe neuromuscular dysfunction, cerebral palsy and death. Hypoxic ischemic encephalopathy (HIE) is the sub cohort of NE that appears to be driven by intrapartum events. Our objective was to identify antepartum and intrapartum factors associated with the development of neonatal HIE. METHODS: Hospital databases were searched using relevant diagnosis codes to identify infants with neonatal encephalopathy...
December 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29224818/reconstruction-after-salvage-laryngectomy
#18
David H Yeh, Axel Sahovaler, Kevin Fung
Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. The effects of radiotherapy to the neck, amplified by chemotherapy, can create an inhospitable surgical environment, making the salvage laryngectomy an operation fraught with the potential for major complications such as the dreaded pharyngocutaneous fistula...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29212391/gene-therapy-successfully-delays-degeneration-in-a-mouse-model-of-pde6a-linked-retinitis-pigmentosa-rp-43
#19
Christian Schön, Vithiyanjali Sothilingam, Regine Mühlfriedel, Marina Garcia Garrido, Susanne C Beck, Naoyuki Tanimoto, Bernd Wissinger, François Paquet-Durand, Martin Biel, Stylianos Michalakis, Mathias W Seeliger, Rd-Cure Consortium
Retinitis pigmentosa type 43 (RP43) is a blinding disease caused by mutations in the gene for rod phosphodiesterase 6 alpha (PDE6A). The disease process begins with a dysfunction of rod photoreceptors, subsequently followed by a currently untreatable progressive degeneration of the entire outer retina. Aiming at a curative approach via PDE6A gene supplementation, we developed a novel adeno-associated viral (AAV) vector for expression of the human PDE6A cDNA under control of the human rhodopsin promotor (rAAV8...
December 7, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29212047/whole-brain-neuronal-abnormalities-in-focal-quantified-with-proton-mr-spectroscopy
#20
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
OBJECTIVE: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (1H-MRS) observed marker, N-acetyl-aspartate (NAA). METHODS: Thirteen patients with localization-related epilepsy (7 men, 6 women) 40±13 (mean±standard-deviation)years old, 8.3±13.4years of disease duration; and 14 matched controls, were scanned at 3 T with MRI and whole-brain (WB) 1H MRS...
December 2, 2017: Epilepsy Research
keyword
keyword
114477
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"