keyword
MENU ▼
Read by QxMD icon Read
search

Multi sclerosis

keyword
https://www.readbyqxmd.com/read/29331092/deep-grey-matter-volume-loss-drives-disability-worsening-in-multiple-sclerosis
#1
Arman Eshaghi, Ferran Prados, Wallace Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsing-remitting[RRMS], 128 secondary-progressive[SPMS], 125 primary-progressive[PPMS]), over an average follow-up of 2...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29321969/the-two-year-progression-of-structural-and-functional-cerebral-mri-in-amyotrophic-lateral-sclerosis
#2
R A L Menke, M Proudfoot, K Talbot, M R Turner
MRI has emerged as one of several urgently needed candidate disease progression biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least due to its unique ability to non-invasively assess structural and functional cerebral pathology. We sought to identify the extent of detectable change in cerebral MRI metrics over a more prolonged period. Analysis of multi-modal MRI data was performed in a cohort of sixteen patients (13 ALS and 3 with primary lateral sclerosis) in whom it was possible to acquire six-monthly images over two years...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29315894/can-t1-w-t2-w-ratio-be-used-as-a-myelin-specific-measure-in-subcortical-structures-comparisons-between-fse-based-t1-w-t2-w-ratios-grase-based-t1-w-t2-w-ratios-and-multi-echo-grase-based-myelin-water-fractions
#3
Md Nasir Uddin, Teresa D Figley, Ruth Ann Marrie, Chase R Figley
Given the growing popularity of T1 -weighted/T2 -weighted (T1 w/T2 w) ratio measurements, the objective of the current study was to evaluate the concordance between T1 w/T2 w ratios obtained using conventional fast spin echo (FSE) versus combined gradient and spin echo (GRASE) sequences for T2 w image acquisition, and to compare the resulting T1 w/T2 w ratios with histologically validated myelin water fraction (MWF) measurements in several subcortical brain structures. In order to compare these measurements across a relatively wide range of myelin concentrations, whole-brain T1 w magnetization prepared rapid acquisition gradient echo (MPRAGE), T2 w FSE and three-dimensional multi-echo GRASE data were acquired from 10 participants with multiple sclerosis at 3 T...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29302474/the-role-of-local-thyroid-hormone-perturbation-in-hippocampal-sclerosis-dementia-commentary-on-a-multi-modality-study
#4
EDITORIAL
Earn H Gan, Salman Razvi
No abstract text is available yet for this article.
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29299124/fty-720-induces-apoptosis-in-neuroblastoma-via-multiple-signaling-pathways
#5
Ingo Lange, Italo Espinoza-Fuenzalida, Mourad Wagdy Ali, Laura Espana Serrano, Dana-Lynn T Koomoa
Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor. High-risk NB is difficult to treat due to the lack of response to current therapies and aggressive disease progression. Despite novel drugs, alternative treatments and multi-modal treatments, finding an effective treatment strategy for these patients continues to be a major challenge. The current study focuses on examining the effects of FTY-720 or fingolimod, a drug that is FDA-approved for refractory multiple sclerosis, in NB. The results showed that FTY-720 regulates multiple pathways that result in various effects on calcium signaling, ion channel activation and cell survival/death pathways...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29251559/structural-refinement-and-prediction-of-potential-ccr2-antagonists-through-validated-multi-qsar-modeling-studies
#6
Sk Abdul Amin, Nilanjan Adhikari, Sandip Kumar Baidya, Shovanlal Gayen, Tarun Jha
Chemokines trigger numerous inflammatory responses and modulate the immune system. The interaction between monocyte chemoattractant protein-1 (MCP-1) and chemokine receptor 2 (CCR2) may be the cause of atherosclerosis, obesity and insulin resistance. However, CCR2 is also implicated in other inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, asthma and neuropathic pain. Therefore, there is a paramount importance of designing potent and selective CCR2 antagonists despite a number of drug candidates failed in clinical trials...
December 18, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29234597/a-supervised-framework-with-intensity-subtraction-and-deformation-field-features-for-the-detection-of-new-t2-w-lesions-in-multiple-sclerosis
#7
Mostafa Salem, Mariano Cabezas, Sergi Valverde, Deborah Pareto, Arnau Oliver, Joaquim Salvi, Àlex Rovira, Xavier Lladó
Introduction: Longitudinal magnetic resonance imaging (MRI) analysis has an important role in multiple sclerosis diagnosis and follow-up. The presence of new T2-w lesions on brain MRI scans is considered a prognostic and predictive biomarker for the disease. In this study, we propose a supervised approach for detecting new T2-w lesions using features from image intensities, subtraction values, and deformation fields (DF). Methods: One year apart multi-channel brain MRI scans were obtained for 60 patients, 36 of them with new T2-w lesions...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29222814/siena-xl-for-improving-the-assessment-of-gray-and-white-matter-volume-changes-on-brain-mri
#8
Marco Battaglini, Mark Jenkinson, Nicola De Stefano
In this article, SIENA-XL, a new segmentation-based longitudinal pipeline is introduced, for: (i) increasing the precision of longitudinal volume change estimation for white (WM) and gray (GM) matter separately, compared with cross-sectional segmentation methods such as SIENAX; and (ii) avoiding potential biases in registration-based methods when Jacobians are used, with a smoothing extent larger than spatial scale between tissue-interfaces, which is where atrophy usually occurs. SIENA-XL implements a new brain extraction procedure and a multi-time-point intensity equalization step before performing the final segmentation that also includes separate segmentation of deep GM structures by using FMRIB's Integrated Registration and Segmentation Tool...
December 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29211682/the-natural-history-of-subependymal-giant-cell-astrocytomas-in-tuberous-sclerosis-complex-a-review
#9
Denise L Chan, Tessa Calder, John A Lawson, David Mowat, Sean E Kennedy
Tuberous sclerosis complex (TSC) is an auto-somal-dominant inherited condition with an incidence of approximately 1:6000 births, characterised by deregulated mTOR activity with multi-site hamartomas. Subependymal giant cell astrocytomas (SEGA) are one such hamartoma, affecting up to 24% of patients with TSC. Their intraventricular location may lead to life-threatening obstructive hydrocephalus. Current management is hampered by a lack of understanding regarding the natural history, behaviour and growth patterns of SEGA...
December 6, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29195756/an-ultrasound-surface-wave-technique-for-assessing-skin-and-lung-diseases
#10
Xiaoming Zhang, Boran Zhou, Sanjay Kalra, Brian Bartholmai, James Greenleaf, Thomas Osborn
Systemic sclerosis (SSc) is a multi-organ connective tissue disease characterized by immune dysregulation and organ fibrosis. Severe organ involvement, especially of the skin and lung, is the cause of morbidity and mortality in SSc. Interstitial lung disease (ILD) includes multiple lung disorders in which the lung tissue is fibrotic and stiffened. The purpose of this study was to translate ultrasound surface wave elastography (USWE) for assessing patients with SSc and/or ILD via measuring surface wave speeds of both skin and superficial lung tissue...
November 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29193892/defective-regulation-of-autoreactive-il-6-producing-transitional-b-lymphocytes-is-associated-with-disease-in-patients-with-systemic-sclerosis
#11
Taher E Taher, Voon H Ong, Jonas Bystrom, Sophie Hillion, Quentin Simon, Christopher P Denton, Jacques-Olivier Pers, David J Abraham, Rizgar A Mageed
BACKGROUND: Systemic Sclerosis (SSc) has the highest case-specific mortality of any rheumatic disease and has no effective therapy. A clear manifestation of SSc is the presence of auto-antibodies. However, the origin of autoantibody-producing B lymphocytes and mechanisms of their activation, auto-antibody production and role remain unclear. OBJECTIVE: To identify mechanisms that contribute to pathogenic B cell generation, involvement in SSc and assess the altered distribution and function of B cells in patients...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29193501/subspecialty-preferences-among-neurologists-of-the-future
#12
Panagiotis Zis, Antonella Macerollo, Anna Sauerbier, Viktoria Papp, Lisa Klingelhoefer, Hannah R Cock
INTRODUCTION: In the era of neurological subspecialization, most neurologists will have a field of specialist interest. The aim of this cross-sectional multi-national study was to identify the key areas of interest among trainees or junior specialists, assess the potential influence of an interest in research, and consider the results in light of population needs. METHODS: A total of 300 residents and junior neurologists who received a bursary to attend the European Academy of Neurology conference were invited to participate in this study...
November 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29190634/focal-segmental-glomerulosclerosis-associated-with-chronic-progressive-external-ophthalmoplegia-and-mitochondrial-dna-a3243g-mutation
#13
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Focal segmental glomerulosclerosis (FSGS) is caused by various etiologies, with mitochondrial dysfunction being one of the causes. FSGS is known to be associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), which is a subclass of mitochondrial disease. However, it has rarely been reported in other mitochondrial disease subclasses. Here, we reported a 20-year-old man diagnosed with FSGS associated with chronic progressive external ophthalmoplegia (CPEO) due to mitochondrial DNA (mtDNA) 3243A>G mutation...
November 30, 2017: Nephron
https://www.readbyqxmd.com/read/29184052/notch-transactivates-rheb-to-maintain-the-multipotency-of-tsc-null-cells
#14
Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkowski, Hossein Mansouri, Maciej M Markiewski, Brandon White, Magdalena Karbowniczek
Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis of these abnormalities remains unclear. Here we report on mechanisms controlling the multi-lineage, early neuronal progenitor and neural stem-like cell characteristics of lymphangioleiomyomatosis (LAM) and angiomyolipoma cells. These mechanisms include the activation of a previously unreported Rheb-Notch-Rheb regulatory loop, in which the cyclic binding of Notch1 to the Notch-responsive elements (NREs) on the Rheb promoter is a key event...
November 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/29177070/evaluation-of-neurological-changes-in-secondary-progressive-multiple-sclerosis-patients-treated-with-immune-modulator-mis416-results-from-a-feasibility-study
#15
Gill A Webster, Dalice A Sim, Anne C La Flamme, Nancy E Mayo
Background: While disease progression can be readily monitored in early stage relapsing multiple sclerosis (MS), it is more challenging for secondary progressive multiple sclerosis (SPMS). This advanced stage of disease has distinct pathophysiology due to compartmentalization of neuroinflammatory activity within the central nervous system, resulting in increased incidence and severity of cognitive dysfunction. The shift in the dominant disease pathways is underscored by the failure of relapsing therapies to benefit SPMS patients, highlighting the need for novel treatment strategies and clinical trial endpoints that are well-aligned with potential benefits...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29175194/brain-signature-of-mild-stages-of-cognitive-and-behavioral-impairment-in-amyotrophic-lateral-sclerosis
#16
Lucas M T Branco, Thiago J R de Rezende, Caroline de O Roversi, Tamires Zanao, Raphael F Casseb, Brunno M de Campos, Marcondes C França
We aimed to assess the brain signature of cognitive and behavioral impairment in C9orf72-negative non-demented ALS patients. The study included 50 amyotrophic lateral sclerosis (ALS) patients (out of 75 initially recruited) and 38 healthy controls. High-resolution T1-weighted and spin-echo diffusion tensor images were acquired in a 3T MRI scanner. The multi atlas-based analysis protocol and the FreeSurfer tool were employed for gray matter assessment, and fiber tractography for white matter evaluation. Cognitively impaired ALS patients (n = 12) had bilateral amygdalae and left thalamic volumetric reduction compared to non-impaired ALS patients...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29162504/checks-and-balances-between-autophagy-and-the-inflammasomes-during-infection
#17
REVIEW
Stephanie Seveau, Joanne Turner, Mikhail A Gavrilin, Jordi B Torrelles, Luanne Hall-Stoodley, Jacob Yount, Amal O Amer
Autophagy and inflammasome complex assembly are physiological processes that control homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway that degrades cytosolic macromolecules or organelles, as well as intracellular pathogens. Inflammasomes are multi-protein complexes that assemble in the cytosol of cells upon detection of pathogen- or danger-associated molecular patterns. A critical outcome of inflammasome assembly is the activation of the serine protease caspase-1, which activates the pro-inflammatory cytokine precursors pro-IL-1β and pro-IL-18...
November 18, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29141788/interleukin-1-receptor-antagonist-and-2-5-oligoadenylate-synthetase-like-molecules-as-novel-biomarkers-for-multiple-sclerosis-patients-in-bahrain
#18
Moudi Al-Nashmi, Safa Taha, Isa Alsharoqi, Moiz Bakhiet
BACKGROUND: Multiple sclerosis (MS) is a multi-factorial disease of the Central Nervous System (CNS) affecting young adults leading to significant disabilities over time. MS is now believed to be prevalent in Arabian Gulf area with high incidence due to environmental factors and unknown genetic variations. The objectives of this study was to detect up-regulated potential genes that might be involved in neuroinflammatory process in MS patients in Bahrain and to measure the protein levels of the expressed genes...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#19
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132389/advances-challenges-and-future-directions-for-stem-cell-therapy-in-amyotrophic-lateral-sclerosis
#20
REVIEW
Yuri Ciervo, Ke Ning, Xu Jun, Pamela J Shaw, Richard J Mead
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss of motor neurons within the brain and spinal cord leads to muscle atrophy, weakness, paralysis and ultimately death within 3-5 years from onset of symptoms. The specific molecular mechanisms underlying the disease pathology are not fully understood and neuroprotective treatment options are minimally effective. In recent years, stem cell transplantation as a new therapy for ALS patients has been extensively investigated, becoming an intense and debated field of study...
November 13, 2017: Molecular Neurodegeneration
keyword
keyword
114475
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"