keyword
MENU ▼
Read by QxMD icon Read
search

Multi sclerosis

keyword
https://www.readbyqxmd.com/read/29141788/interleukin-1-receptor-antagonist-and-2-5-oligoadenylate-synthetase-like-molecules-as-novel-biomarkers-for-multiple-sclerosis-patients-in-bahrain
#1
Moudi Al-Nashmi, Safa Taha, Isa Alsharoqi, Moiz Bakhiet
BACKGROUND: Multiple sclerosis (MS) is a multi-factorial disease of the Central Nervous System (CNS) affecting young adults leading to significant disabilities over time. MS is now believed to be prevalent in Arabian Gulf area with high incidence due to environmental factors and unknown genetic variations. The objectives of this study was to detect up-regulated potential genes that might be involved in neuroinflammatory process in MS patients in Bahrain and to measure the protein levels of the expressed genes...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#2
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132389/advances-challenges-and-future-directions-for-stem-cell-therapy-in-amyotrophic-lateral-sclerosis
#3
REVIEW
Yuri Ciervo, Ke Ning, Xu Jun, Pamela J Shaw, Richard J Mead
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss of motor neurons within the brain and spinal cord leads to muscle atrophy, weakness, paralysis and ultimately death within 3-5 years from onset of symptoms. The specific molecular mechanisms underlying the disease pathology are not fully understood and neuroprotective treatment options are minimally effective. In recent years, stem cell transplantation as a new therapy for ALS patients has been extensively investigated, becoming an intense and debated field of study...
November 13, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29121642/limbic-system-damage-in-ms-mri-assessment-and-correlations-with-clinical-testing
#4
Jie Wen, Dmitriy A Yablonskiy, Amber Salter, Anne H Cross
Volume loss in some limbic region structures has been observed in multiple sclerosis (MS) patients. However, in vivo evaluation of existing tissue cellular microstructure integrity has received less attention. The goal of studies reported here was to quantitatively assess loss of limbic system volumes and tissue integrity, and to evaluate associations of these measures with cognitive and physical dysfunction in MS patients. Thirty-one healthy controls (HC) and 80 MS patients, including 32 relapsing remitting (RRMS), 32 secondary progressive (SPMS) and 16 primary progressive (PPMS), participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29103086/a-novel-public-mr-image-dataset-of-multiple-sclerosis-patients-with-lesion-segmentations-based-on-multi-rater-consensus
#5
Žiga Lesjak, Alfiia Galimzianova, Aleš Koren, Matej Lukin, Franjo Pernuš, Boštjan Likar, Žiga Špiclin
Quantified volume and count of white-matter lesions based on magnetic resonance (MR) images are important biomarkers in several neurodegenerative diseases. For a routine extraction of these biomarkers an accurate and reliable automated lesion segmentation is required. To objectively and reliably determine a standard automated method, however, creation of standard validation datasets is of extremely high importance. Ideally, these datasets should be publicly available in conjunction with standardized evaluation methodology to enable objective validation of novel and existing methods...
November 4, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/29076640/a-systematic-review-of-the-epidemiology-disease-characteristics-and-management-of-systemic-sclerosis-in-australian-adults
#6
Kathleen Morrisroe, Wendy Stevens, Susanna Proudman, Mandana Nikpour
OBJECTIVE: Australia has one of the highest prevalence rates of systemic sclerosis (SSc) worldwide. In order to highlight management deficiencies and key areas for further research, it is essential to understand its local epidemiological patterns, natural history, prognosis and mortality trends over time. METHODS: To identify Australian SSc-specific information through a systematic review focusing on areas of epidemiology, disease characteristics, treatment, functional ability, disease burden and health-related quality of life (HRQoL)...
October 27, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29073458/resting-state-fmri-correlates-of-theory-of-mind-impairment-in-amyotrophic-lateral-sclerosis
#7
Francesca Trojsi, Federica Di Nardo, Gabriella Santangelo, Mattia Siciliano, Cinzia Femiano, Carla Passaniti, Giuseppina Caiazzo, Michele Fratello, Mario Cirillo, Maria Rosaria Monsurrò, Fabrizio Esposito, Gioacchino Tedeschi
Theory of Mind (ToM), the ability to recognize thoughts and emotions of another, may be one of the cognitive domains affected in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease now recognized as a multi-system disorder. The present study aimed to identify early dysfunctions of brain resting state functional magnetic resonance imaging (RS-fMRI) networks in a group of ALS patients longitudinally explored for impairment of "cognitive" and "affective" ToM subcomponents. RS-fMRI connectivity was investigated in a group of 21 patients with ALS (i...
October 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29073343/prevalence-and-disease-specific-risk-factors-for-lower-urinary-tract-symptoms-in-systemic-sclerosis-an-international-multi-centric-study
#8
Gregor John, Jérôme Avouac, Silvia Piantoni, Pamela Polito, Micaela Fredi, Franco Cozzi, Paolo Airo, Marie-Elise Truchetet, Franco Franceschini, Yannick Allanore, Carlo Chizzolini
OBJECTIVE: The aim of the present study was to determine the prevalence of lower urinary tract symptoms (LUTS) in systemic sclerosis (SSc), to find specific risk factors and to assess their impact on quality of life (QoL). METHODS: In a multi-centric study, 334 patients completed a self-administered questionnaire on LUTS and QoL. LUTS were classified into three main categories: storage, voiding, and post micturition symptoms. Digestive symptoms burden was captured by a visual analogic scale, divided into five equal categories...
October 26, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29071282/identification-of-mir-24-and-mir-137-as-novel-candidate-multiple-sclerosis-mirna-biomarkers-using-multi-staged-data-analysis-protocol
#9
Farveh Ehya, Hossein Abdul Tehrani, Masoud Garshasbi, Seyed Masood Nabavi
Many studies have investigated misregulation of miRNAs relevant to multiple sclerosis (MS) pathogenesis. Abnormal miRNAs can be used both as candidate biomarker for MS diagnosis and understanding the disease miRNA-mRNA regulatory network. In this comprehensive study, misregulated miRNAs related to MS were collected from existing literature, databases and via in silico prediction. A multi-staged data integration strategy (including the construction of miRNA-mRNA regulatory network and systematic data analysis) was conducted in order to investigate MS related miRNAs and their regulatory networks...
September 2017: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29060535/early-axonal-damage-in-normal-appearing-white-matter-in-multiple-sclerosis-novel-insights-from-multi-shell-diffusion-mri
#10
Silvia De Santis, Tobias Granberg, Russell Ouellette, Constantina A Treaba, Qiuyun Fan, Elena Herranz, Caterina Mainero, Nicola Toschi
Conventional diffusion-weighted MR imaging techniques provide limited specificity in disentangling disease-related microstructural alterations involving changes in both axonal density and myelination. By simultaneously probing multiple diffusion regimens, multi-shell diffusion MRI is capable of increasing specificity to different tissue sub-compartments and hence separate different contributions to changes in diffusion-weighted signal attenuation. Advanced multi-shell diffusion models impose significant requirements on the amount of diffusion weighting (i...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054467/the-multi-dimensional-roles-of-astrocytes-in-als
#11
REVIEW
Koji Yamanaka, Okiru Komine
Despite significant progress in understanding the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the progressive loss of motor neurons, the precise and comprehensive pathomechanisms remain largely unknown. In addition to motor neuron involvement, recent studies using cellular and animal models of ALS indicate that there is a complex interplay between motor neurons and neighboring non-neuronal cells, such as astrocytes, in non-cell autonomous neurodegeneration...
October 17, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29053775/neuroinflammation-and-its-relationship-to-changes-in-brain-volume-and-white-matter-lesions-in-multiple-sclerosis
#12
Gourab Datta, Alessandro Colasanti, Eugenii A Rabiner, Roger N Gunn, Omar Malik, Olga Ciccarelli, Richard Nicholas, Eline Van Vlierberghe, Wim Van Hecke, Graham Searle, Andre Santos-Ribeiro, Paul M Matthews
Brain magnetic resonance imaging is an important tool in the diagnosis and monitoring of multiple sclerosis patients. However, magnetic resonance imaging alone provides limited information for predicting an individual patient's disability progression. In part, this is because magnetic resonance imaging lacks sensitivity and specificity for detecting chronic diffuse and multi-focal inflammation mediated by activated microglia/macrophages. The aim of this study was to test for an association between 18 kDa translocator protein brain positron emission tomography signal, which arises largely from microglial activation, and measures of subsequent disease progression in multiple sclerosis patients...
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29046903/fod-restoration-for-enhanced-mapping-of-white-matter-lesion-connectivity
#13
Wei Sun, Lilyana Amezcua, Yonggang Shi
To achieve improved understanding of white matter (WM) lesions and their effect on brain functions, it is important to obtain a comprehensive map of their connectivity. However, changes of the cellular environment in WM lesions attenuate diffusion MRI (dMRI) signals and make the robust estimation of fiber orientation distributions (FODs) difficult. In this work, we integrate techniques from image inpainting and compartment modeling to develop a novel method for enhancing FOD estimation in WM lesions from multi-shell dMRI, which is becoming increasingly popular with the success of the Human Connectome Project (HCP)...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29041871/advancing-trial-design-in-progressive-multiple-sclerosis
#14
Robert J Fox, Jeremy Chataway
The failure of a majority of clinical trials in progressive multiple sclerosis (MS) has highlighted the need to reconsider how these trials are designed and conducted, and many areas deserve focus. Basic scientists are reconceptualising the pathophysiology of progressive MS into three broad areas: systemic inflammation, compartmentalized inflammation and non-inflammatory neurodegeneration, with the latter two becoming predominant as the disease progresses. This framework will guide the choice of experimental therapies...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29035222/an-advanced-mri-multi-modalities-segmentation-methodology-dedicated-to-multiple-sclerosis-lesions-exploration-and-differentiation
#15
Olfa Ghribi, Lamia Sellami, Mohamed Ben Slima, Ahmed Ben Hamida, Chokri Mhiri, Keireddine Ben Mahfoudh
Multiple sclerosis is one of the most common neurological diseases in young people. This paper dealt with an automatic biomedical aided tool involving volumetric segmentation of Multiple Sclerosis lesions. To meet this challenge, our proposed methodology requires one preliminary cerebral zones segmentation performed using a new Gaussian Mixture Model based on various databases atlases. Afterwards, lesion segmentation begins with the estimation of a lesion map which is then subjected to threshold constraints and refined by a new lesion expansion algorithm...
October 16, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29033951/sphingosine-1-phosphate-receptor-5-modulates-early-stage-processes-during-fibrogenesis-in-a-mouse-model-of-systemic-sclerosis-a-pilot-study
#16
Katrin G Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M Pfeilschifter, Heinfried H Radeke
Systemic sclerosis (SSc) is a rare multi-organ autoimmune disease characterized by progressive skin fibrosis. Inflammation, type 2 immunity, and fibrogenic processes are involved in disease development and may be affected by sphingolipids. However, details about early-stage pathophysiological mechanisms and implicated mediators remain elusive. The sphingolipid sphingosine-1-phosphate (S1P) is elevated in the sera of SSc patients, and its receptor S1P5 is expressed in skin tissue. Nevertheless, almost nothing is known about the dermatological contribution of S1P5 to inflammatory and pro-fibrotic processes leading to the pathological changes seen in SSc...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29029388/rapamycin-induced-mir-21-promotes-mitochondrial-homeostasis-and-adaptation-in-mtorc1-activated-cells
#17
Hilaire C Lam, Heng-Jia Liu, Christian V Baglini, Harilaos Filippakis, Nicola Alesi, Julie Nijmeh, Heng Du, Alicia Llorente Lope, Katherine A Cottrill, Adam Handen, John M Asara, David J Kwiatkowski, Issam Ben-Sahra, William M Oldham, Stephen Y Chan, Elizabeth P Henske
mTORC1 hyperactivation drives the multi-organ hamartomatous disease tuberous sclerosis complex (TSC). Rapamycin inhibits mTORC1, inducing partial tumor responses; however, the tumors regrow following treatment cessation. We discovered that the oncogenic miRNA, miR-21, is increased in Tsc2-deficient cells and, surprisingly, further increased by rapamycin. To determine the impact of miR-21 in TSC, we inhibited miR-21 in vitro. miR-21 inhibition significantly repressed the tumorigenic potential of Tsc2-deficient cells and increased apoptosis sensitivity...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021214/casein-kinase-ii-phosphorylation-of-cyclin-f-at-serine-621-regulates-the-lys48-ubiquitylation-e3-ligase-activity-of-the-scf-cyclin-f-complex
#18
Albert Lee, Stephanie L Rayner, Alana De Luca, Serene S L Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L Williams, Emily K Don, Adam K Walker, Katharine Y Zhang, Justin J Yerbury, Nicholas J Cole, Julie D Atkin, Ian P Blair, Mark P Molloy, Roger S Chung
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3-5 years of diagnosis. Recently, we identified disease-linked mutations in the CCNF gene, which encodes the cyclin F protein, in cohorts of patients with familial and sporadic ALS and frontotemporal dementia (FTD) (Williams KL et al 2016 Nat. Commun.7, 11253. (doi:10.1038/ncomms11253)). Cyclin F is a part of a Skp1-Cul-F-box (SCF) E3 ubiquitin-protein ligase complex and is responsible for ubiquitylating proteins for degradation by the proteasome...
October 2017: Open Biology
https://www.readbyqxmd.com/read/29019158/cost-effectiveness-of-nurse-delivered-cognitive-behavioural-therapy-cbt-compared-to-supportive-listening-sl-for-adjustment-to-multiple-sclerosis
#19
I Mosweu, R Moss-Morris, L Dennison, T Chalder, P McCrone
BACKGROUND: Cognitive Behavioural Therapy (CBT) reduces distress in multiple sclerosis, and helps manage adjustment, but cost-effectiveness evidence is lacking. METHODS: An economic evaluation was conducted within a multi-centre trial. 94 patients were randomised to either eight sessions of nurse-led CBT or supportive listening (SL). Costs were calculated from the health, social and indirect care perspectives, and combined with additional quality-adjusted life years (QALY) or improvement on the GHQ-12 score, to explore cost-effectiveness at 12 months...
October 10, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28988297/risk-association-between-scleroderma-disease-characteristics-periodontitis-and-tooth-loss
#20
Gaetano Isola, Ray C Williams, Alberto Lo Gullo, Luca Ramaglia, Marco Matarese, Vincenzo Iorio-Siciliano, Claudio Cosio, Giovanni Matarese
Systemic sclerosis (SSc) is a multi-system disorder that can have significant adverse effects on the health of the mouth. The aim of this study was to investigate the associations between the disease characteristics of SSc, periodontal disease (PD), and tooth loss. Fifty-four patients affected by SSc and 55 non-diseased controls were matched for age and gender. SSc was characterized in subtypes and with the mean duration of disease and the Modified Rodnan Skin Score [mRSS]. Patients were surveyed and examined through the evaluation of the periodontal parameters and the number of teeth...
December 2017: Clinical Rheumatology
keyword
keyword
114475
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"