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https://www.readbyqxmd.com/read/29778035/formation-of-contact-active-antimicrobial-surfaces-by-covalent-grafting-of-quaternary-ammonium-compounds
#1
REVIEW
Poverenov Elena, Klein Miri
Different synthetic strategies for the formation of contact active antimicrobial materials utilizing covalent linkage of quaternary ammonium compounds (QACs) were reviewed. There is a demand to find methods that will prevent bacterial fouling without the release of antimicrobial agents, because biocides cause environment pollution and promote the development of bacteria resistance mechanisms. The contact active antimicrobial surfaces may provide a useful tool for this purpose. The covalent surface grafting of QACs seems to be a feasible and promising approach for the formation of safe and effective antimicrobial materials that could be utilized for medical devices, food industry, water treatment systems and other applications...
May 16, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29762322/maternal-folic-acid-supplementation-and-the-risk-of-oral-clefts-in-offspring
#2
Arezoo Jahanbin, Elaheh Shadkam, Hamid Heidarian Miri, Alireza Sarraf Shirazi, Mostafa Abtahi
INTRODUCTION: There is controversial evidence from the literature regarding the protective effect of folic acid supplementation during pregnancy against orofacial clefts. The authors undertook this meta-analysis to assess whether folate supplementation during pregnancy can reduce the risk of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) in infants. METHODS: Eligible articles were identified by searching databases, including PubMed, Medline, Scopus, ISI (Web of Knowledge) to September 2017...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761763/in-southern-nigeria-loa-loa-blood-microfilaria-density-is-very-low-even-in-areas-with-high-prevalence-of-loiasis-results-of-a-survey-using-the-new-loascope-technology
#3
Emmanuel Emukah, Lindsay J Rakers, Barminas Kahansim, Emmanuel S Miri, Bertram E B Nwoke, Emily Griswold, Yisa Saka, Ifeoma Anagbogu, Emmanuel Davies, Cephas Ityonzughul, Michael D'Ambrosio, Matthew Bakalar, Daniel A Fletcher, Thomas Nutman, Joseph Kamgno, Frank O Richards
Ivermectin treatment can cause central nervous system adverse events (CNS-AEs) in persons with very high-density Loa loa microfilaremia (≥ 30,000 mf/mL blood). Hypoendemic onchocerciasis areas where L. loa is endemic have been excluded from ivermectin mass drug administration programs (MDA) because of the concern for CNS AEs. The rapid assessment procedure for L. loa (RAPLOA) is a questionnaire survey to assess history of eye worm. If ≥ 40% of respondents report eye worm, this correlates with ≥ 2% prevalence of very high-density loiasis microfilaremia, posing an unacceptable risk of CNS-AEs after MDA...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29761670/arrhythmic-events-in-brugada-syndrome-a-nationwide-israeli-survey-of-the-clinical-characteristics-treatment-and-long-term-follow-up-israbru-vf
#4
Eran Leshem, Michael Rahkovich, Anna Mazo, Mahmoud Suleiman, Miri Blich, Avishag Laish-Farkash, Yuval Konstantino, Rami Fogelman, Boris Strasberg, Michael Geist, Israel Chetboun, Moshe Swissa, Michael Ilan, Aharon Glick, Yoav Michowitz, Raphael Rosso, Michael Glikson, Bernard Belhassen
BACKGROUND: Limited information exists about detailed clinical characteristics and management of the small subset of Brugada syndrome (BrS) patients who had an arrhythmic event (AE). OBJECTIVES: To conduct the first nationwide survey focused on BrS patients with documented AE. METHODS: Israeli electrophysiology units participated if they had treated BrS patients who had cardiac arrest (CA) (lethal/aborted; group 1) or experienced appropriate therapy for tachyarrhythmias after prophylactic implantable cardioverter defibrillator (ICD) implantation (group 2)...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29759914/symptom-cluster-of-emotional-distress-fatigue-and-cognitive-difficulties-among-young-and-older-breast-cancer-survivors-the-mediating-role-of-subjective-stress
#5
Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta Fried
OBJECTIVES: To examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster. MATERIALS AND METHODS: Participants were 170 BCS, stages I-III, 1-12 months post-chemotherapy, filled-out the Fatigue, Emotional Control, Meaning-focused Coping, Emotional Distress and the Cognitive Difficulties Questionnaires...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29742100/the-receptor-protein-tyrosine-phosphatase-clr-1-is-required-for-synaptic-partner-recognition
#6
Aruna Varshney, Kelli Benedetti, Katherine Watters, Raakhee Shankar, David Tatarakis, Doris Coto Villa, Khristina Magallanes, Venia Agenor, William Wung, Fatima Farah, Nebat Ali, Nghi Le, Jacqueline Pyle, Amber Farooqi, Zanett Kieu, Martina Bremer, Miri VanHoven
During neural circuit formation, most axons are guided to complex environments, coming into contact with multiple potential synaptic partners. However, it is critical that they recognize specific neurons with which to form synapses. Here, we utilize the split GFP-based marker Neuroligin-1 GFP Reconstitution Across Synaptic Partners (NLG-1 GRASP) to visualize specific synapses in live animals, and a circuit-specific behavioral assay to probe circuit function. We demonstrate that the receptor protein tyrosine phosphatase (RPTP) clr-1 is necessary for synaptic partner recognition (SPR) between the PHB sensory neurons and the AVA interneurons in C...
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29741915/the-role-of-microrna-1-targeting-mapk3-in-myocardial-ischemia-reperfusion-injury-in-rats-undergoing-sevoflurane-preconditioning-via-the-pi3k-akt-pathway
#7
Yun-Ling Hao, Hong-Cheng Fang, Hong-Lei Zhao, Xiao-Li Li, Ying Luo, Bao-Quan Wu, Ming-Jie Fu, Wei Liu, Jin-Jie Liang, Xie-Hui Chen
Recent studies have uncovered the vital roles played by microRNAs (miRNAs) in regulating cardiac injury. Amongst them, the cardiac enriched microRNA-1 (miR-1) has been extensively studied and proven to be detrimental to cardiac myocytes. Hence, the current study aims to explore whether miR-1 affects myocardial ischemia/reperfusion injury (MIRI) in rats undergoing sevoflurane preconditioning and the underlying mechanism. After successful model establishment, rats with MIRI were transfected with mimics or inhibitors of miR-1, or siRNA against MAPK3, and then were injected with sevoflurane...
May 9, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29737048/microfluidics-enabled-multimaterial-maskless-stereolithographic-bioprinting
#8
Amir K Miri, Daniel Nieto, Luis Iglesias, Hossein Goodarzi Hosseinabadi, Sushila Maharjan, Guillermo U Ruiz-Esparza, Parastoo Khoshakhlagh, Amir Manbachi, Mehmet Remzi Dokmeci, Shaochen Chen, Su Ryon Shin, Yu Shrike Zhang, Ali Khademhosseini
A stereolithography-based bioprinting platform for multimaterial fabrication of heterogeneous hydrogel constructs is presented. Dynamic patterning by a digital micromirror device, synchronized by a moving stage and a microfluidic device containing four on/off pneumatic valves, is used to create 3D constructs. The novel microfluidic device is capable of fast switching between different (cell-loaded) hydrogel bioinks, to achieve layer-by-layer multimaterial bioprinting. Compared to conventional stereolithography-based bioprinters, the system provides the unique advantage of multimaterial fabrication capability at high spatial resolution...
May 7, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29731750/macrophage-lamin-a-c-regulates-inflammation-and-the-development-of-obesity-induced-insulin-resistance
#9
Youngjo Kim, Princess Wendy Bayona, Miri Kim, Jiyeon Chang, Sunmin Hong, Yoona Park, Andrea Budiman, Yong-Jin Kim, Chang Yong Choi, Woo Seok Kim, Jongsoon Lee, Kae Won Cho
Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclear lamina is associated with age-associated chronic inflammation in humans and fly. These findings led us to investigate whether the nuclear lamina regulates obesity-mediated chronic inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29728562/optical-circulation-in-a-multimode-optomechanical-resonator
#10
Freek Ruesink, John P Mathew, Mohammad-Ali Miri, Andrea Alù, Ewold Verhagen
Breaking the symmetry of electromagnetic wave propagation enables important technological functionality. In particular, circulators are nonreciprocal components that can route photons directionally in classical or quantum photonic circuits and offer prospects for fundamental research on electromagnetic transport. Developing highly efficient circulators thus presents an important challenge, especially to realise compact reconfigurable implementations that do not rely on magnetic fields to break reciprocity. We demonstrate optical circulation utilising radiation pressure interactions in an on-chip multimode optomechanical system...
May 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29720135/compliance-with-iron-and-folic-acid-supplementation-ifas-and-associated-factors-among-pregnant-women-results-from-a-cross-sectional-study-in-kiambu-county-kenya
#11
Mary Wanjira Kamau, Waithira Mirie, Samuel Kimani
BACKGROUND: Macro and micronutrients including iron and folic acid deficiencies are prevalent in Kenya, particularly during pregnancy resulting in anaemia. Despite efforts to control anaemia in pregnancy by adopting Iron and Folic Acid Supplementation (IFAS), this public health problem has persisted contributing to significant morbidity and mortality. The problem notwithstanding, there is poor IFAS compliance, whose reasons remain poorly understood, calling for their investigations. We sought to determine compliance status with IFAS and associated factors among pregnant women...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29714717/dosimetric-factors-for-diagnostic-nuclear-medicine-procedures-in-a-non-reference-pregnant-phantom
#12
Laleh Rafat-Motavalli, Hashem Miri Hakimabad, Elie Hoseinian Azghadi
This study was evaluated the impact of using non-reference fetal models on the fetal radiation dose from diagnostic radionuclide administration. The 6 month pregnant phantoms including fetal models at 10th and 90th growth percentiles were constructed at either end of the normal range around the 50th percentile and implemented in the Monte Carlo N-Particle code version MCNPX 2.6. The code have been used then to evaluate the 99mTc S factors of interested target organs as the most common used radionuclide in nuclear medicine procedures...
May 1, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29706311/the-association-between-obesity-and-migraine-in-a-population-of-iranian-adults-a-case-control-study
#13
Ali Miri, Morteza Nasiri, Sahar Zonoori, Fatemeh Yarahmad, Arasb Dabbagh-Moghadam, Gholamreza Askari, Omid Sadeghi, Masoumeh Asadi
AIM: To assess the association between obesity and risk of migraine with aura and features of migraine attacks among a population of Iranian adults. METHODS: In this case-control study, 102 confirmed cases of migraine with aura were matched based on age and gender with 102 healthy subjects. Data on demographic characteristics and anthropometric measurements were collected from all cases and controls by the same methods. Overweight and obesity were considered as body mass index ≥25-30 kg/m2 and ≥ 30 kg/m2 , respectively...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29698559/tuftsin-phosphorylcholine-tpc-equally-effective-to-methylprednisolone-in-ameliorating-lupus-nephritis-in-a-mice-model
#14
Asaf Shemer, Shay Kivity, Ora Shovman, Ori Perry, Abdulla Watad, Dana Ben-Ami Shor, Alex Volkov, Iris Barshack, Nicola L Bragazzi, Alexander Krule, Mati Fridkin, Howard Amital, Miri Blank, Yehuda Shoenfeld
BACKGROUND: The role of helminth treatment in autoimmune diseases is constantly growing. Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with challenging treatment options. Tuftsin phosphorylcholine (TPC) is a novel helminth-based compound that modulates the host immune network. OBJECTIVES: This study was conducted to evaluate the potential value of TPC in ameliorating lupus nephritis in a murine model and specifically to compare the efficacy of TPC to the existing first-line therapy for SLE: corticosteroids (methylprednisolone)...
April 26, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29697291/vildagliptin-recruits-regulatory-t-cells-in-patients-undergoing-primary-percutaneous-coronary-intervention
#15
Fatma H Rizk, Muhammad Tarek Abdel Ghafar, Nema A Soliman, Aliaa E Shaaban, Ramy Atlam, Amiraa Elsaadany, Kareman Ahmed Eshra, Marwa Mostafa Shalaby
Regulatory T cells (Treg) has been documented to be protective against myocardial ischemia-reperfusion injury (MIRI). The administration of drugs which recruit Treg cells may participate in the cardioprotection of MIRI. The purpose of the present study was to investigate whether the add-on vildagliptin (vild) to standard treatment of MIRI prior to reperfusion could increase Treg recruitment, anti-inflammatory, and antioxidant effects of the standard treatment or not. Sixty diabetic patients with ST-segment elevation myocardial infarction were randomly divided into two equal groups: control group was given the standard medical treatment and vild group was given the standard medical treatment plus vild...
April 26, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29688912/tilianin-loaded-ros-scavenging-nano-micelles-protect-h9c2-cardiomyocyte-against-hypoxia-reoxygenation-induced-injury
#16
Yanfang Wang, Ying Wang, Xinchun Wang, Ping Hu
Previous studies have shown that Tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano micelles that may overcome this critical issue are presented. A polyethylene glycol compound (PEG) was covalently attached to propylene sulfide formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed tilianin loaded micelles (TLMs)...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29688178/coronary-sinus-reducer-implantation-improves-symptoms-ischemia-and-physical-capacity-in-patients-with-refractory-angina-unsuitable-for-myocardial-revascularization-a-single-center-experience
#17
Maayan Konigstein, Samuel Bazan, Miri Revivo, Shmuel Banai
AIMS: To evaluate the clinical efficacy of the Coronary Sinus Reducer implantation in alleviating angina symptoms and improving objective ischemia parameters and indices of physical capacity Methods and results: Patient with refractory angina (CCS class 3-4) were treated with the Reducer. Baseline, and follow-up evaluation consisted of clinical assessment including completion of Seattle angina Questionnaire (SAQ) and CCS class evaluation, and objective assessment by treadmill exercise test, Dobutamine echocardiography and 6-minute walk test (6MWT)...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29687576/mammographic-breast-density-in-recent-and-longer-standing-ethiopian-immigrants-to-israel
#18
Miri Sklair-Levy, Anat Segev, Tamar Sella, Ronit Calderon-Margalit, Douglas Zippel
High breast density is associated with an increased risk of breast cancer development. Little is known concerning ethnic variations in breast density and its relevant contributing factors. We aimed to study breast density among Ethiopian immigrants to Israel in comparison with Israeli-born women and to determine any effect on breast density of the length of residency in the immigrant population. Mammographic breast density using the BI-RADS system was estimated and compared between 77 women of Ethiopian origin who live in Israel and 177 Israeli-born controls...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29683654/effect-of-co-2-phase-states-and-flow-rate-on-salt-precipitation-in-shale-caprocks-a-microfluidic-study
#19
Mohammad Nooraiepour, Hossein Fazeli, Rohaldin Miri, Helge Hellevang
Fracture networks inside the caprock for CO2 storage reservoirs may serve as leakage pathways. Fluid flow through fractured caprocks and bypass conduits, however, can be restrained or diminished by mineral precipitations. This study investigates precipitation of salt crystals in an artificial fracture network as a function of pressure-temperature conditions and CO2 phase states. The impact of CO2 flow rate on salt precipitation was also studied. The primary research objective was to examine whether salt precipitation can block potential CO2 leakage pathways...
April 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29683527/modulation-of-allergic-responses-by-mitochondrial-stat3-inhibitors
#20
Tal Erlich, Israa Sharkia, Nadine Landolina, Miri Assayag, Omer Goldberger, Neville Berkman, Francesca Levi-Schafer, Ehud Razin
Recently we have shown that mast cell mitochondrial STAT3 could serve as a new target for the regulation of the allergic response as it plays an essential role in immunologically-mediated degranulation of mast cells. In the present work, we explored how two recently developed mitochondrial STAT3 inhibitors (Mitocur-1 and Mitocur-3) modulate the allergic response. Here we show that treatment of rodent and human cultured mast cells with low concentrations of mitochondrial STAT3 inhibitors had no effect on STAT3 target gene expression...
April 23, 2018: Allergy
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