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Elad Moisseiev, Miri Fogel, Ido Didi Fabian, Adiel Barak, Joseph Moisseiev, Amir Alhalel
PURPOSE: To evaluate the indications, outcomes, and complications of scleral buckle removal over the past decade and compare to previously published data. METHODS: Forty nine eyes of 49 patients who underwent scleral buckle removal and had at least 6 months of follow-up were included in this retrospective study. Recorded parameters included demographic information, history of the retinal detachment, details of the scleral buckling surgery, indication for scleral buckle removal, time from scleral buckle placement to removal, culture results, length of follow up, visual acuity (VA) throughout the follow up, and the occurrence of any complications or need for additional surgery after scleral buckle removal...
December 2, 2016: Current Eye Research
Miri Kim, Hyun Soo Kim, Min Ah Kim, Hyanghwa Ryu, Hwan-Jeong Jeong, Chang-Moon Lee
Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol-Mel) does not show any precipitation and shows sol-gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm(-2) for 3 min, the photothermal conversion efficiency of Pol-Mel is enough to kill cancer cells in vitro and in vivo...
December 1, 2016: Macromolecular Bioscience
Miri Park, Yochan Joung, Gi Gyun Nam, Suhyun Kim, Jang-Cheon Cho
A Gram-staining-negative, non-motile, yellow-pigmented bacterium, designated strain IMCC27201T, was isolated from an artificial freshwater pond (Inkyong). Growth of strain IMCC27201T occurred at 10-37 °C (optimum, 30 °C), at pH 7.0-8.0 (optimum, pH 7.0) and with 0-0.25 % NaCl (optimum, 0 %). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain IMCC27201T belonged to the genus Flavobacterium and is most closely related to Flavobacterium columnare IFO 15943T (97.8  % sequence similarity), Flavobacterium terrae R2A1-13T (97...
October 16, 2016: International Journal of Systematic and Evolutionary Microbiology
Freek Ruesink, Mohammad-Ali Miri, Andrea Alù, Ewold Verhagen
Nonreciprocal components, such as isolators and circulators, provide highly desirable functionalities for optical circuitry. This motivates the active investigation of mechanisms that break reciprocity, and pose alternatives to magneto-optic effects in on-chip systems. In this work, we use optomechanical interactions to strongly break reciprocity in a compact system. We derive minimal requirements to create nonreciprocity in a wide class of systems that couple two optical modes to a mechanical mode, highlighting the importance of optically biasing the modes at a controlled phase difference...
November 29, 2016: Nature Communications
Harminder S Dua, Ammar Miri, Mohamed S Elalfy, Anna Lencova, Dalia G Said
AIMS: To develop a technique using amniotic membrane (AM) to prevent admixture of conjunctival epithelial cells and limbal explant-derived corneal epithelial cells in patients undergoing limbal stem cell transplantation. To compare this technique with the current method of 'sequential sector conjunctival epitheliectomy' (SSCE). METHODS: 26 patients with total limbal stem cell deficiency who underwent ocular surface reconstruction with limbal stem cells transplantation were retrospectively studied...
November 25, 2016: British Journal of Ophthalmology
Faezeh Fatemi, Saba Miri, Samaneh Jahani
In Acidithiobacillus ferrooxidans, one of the most important bioleaching bacterial species, the proteins encoded by the rus operon are involved in the electron transfer from Fe(2+) to O2. To obtain further knowledge about the mechanism(s) involved in the adaptive responses of the bacteria to growth on the different uranium ore pulp densities, we analyzed the expression of the four genes from the rus operon by real-time PCR, when Acidithiobacillus sp. FJ2 was grown in the presence of different uranium concentrations...
November 24, 2016: Archives of Microbiology
Mohsen Ebrahimi, Omidreza Firuzi, Ramin Miri, Nima Razzaghi-Asl, Ahmad Ebadi
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is modified by cyclooxygenases into active compounds called eicosanoids that act as signaling molecules in a number of physiological processes. Excessive production of eicosanoids leads to several pathological conditions such as inflammation. In order to block the inflammatory effect of these compounds, upstream enzymes such as PLA2 are valid targets. In the present contribution, molecular dynamic analysis was performed to evaluate the binding of diclofenac, 9-hydroxy aristolochic acid (9-HAA) and indomethacin to PLA2...
November 22, 2016: Interdisciplinary Sciences, Computational Life Sciences
Israa Sharkia, Tal Hadad Erlich, Nadine Landolina, Miri Assayag, Alex Motzik, Inbal Rachmin, Gillian Kay, Ziv Porat, Sagi Tshori, Neville Berkman, Francesca Levi-Schaffer, Ehud Razin
BACKGROUND: We have recently observed that OXPHOS mediated ATP production is essential for mast cell function. Pyruvate dehydrogenase (PDH) is the main regulator of the Krebs cycle and is located upstream to the electron transport chain. However, the role of PDH in mast cell function has not been described. Microphthalmia transcription factor (MITF) regulates the development, number and function of mast cells. The localization of MITF to the mitochondria and its interaction with mitochondrial proteins has not been explored...
November 18, 2016: Journal of Allergy and Clinical Immunology
Wanjun Liu, Yu Shrike Zhang, Marcel A Heinrich, Fabio De Ferrari, Hae Lin Jang, Syeda Mahwish Bakht, Mario Moisés Alvarez, Jingzhou Yang, Yi-Chen Li, Grissel Trujillo-de Santiago, Amir K Miri, Kai Zhu, Parastoo Khoshakhlagh, Gyan Prakash, Hao Cheng, Xiaofei Guan, Zhe Zhong, Jie Ju, Geyunjian Harry Zhu, Xiangyu Jin, Su Ryon Shin, Mehmet Remzi Dokmeci, Ali Khademhosseini
The development of a multimaterial extrusion bioprinting platform is reported. This platform is capable of depositing multiple coded bioinks in a continuous manner with fast and smooth switching among different reservoirs for rapid fabrication of complex constructs, through digitally controlled extrusion of bioinks from a single printhead consisting of bundled capillaries synergized with programmed movement of the motorized stage.
November 17, 2016: Advanced Materials
Zhe Chen, Di Wu, Lanfang Li, Linxi Chen
Apelin is the endogenous ligand of the G protein-coupled receptor, APJ. Recently, researches indicate that the apelin/APJ system involves in myocardial ischemia-reperfusion injury (MIRI), which is a common pathophysiological process in patients with heart diseases and therapies. The reperfusion induces the expression of apelin and APJ receptor, which play an important role in cardioprotection of MIRI. The apelin/APJ system alleviates MIRI mainly by decreasing mitochondrial reactive oxygen species and delaying the opening of mitochondrial permeability transition pores, which induce the initiation of mitophagy...
November 17, 2016: DNA and Cell Biology
Sewon Hwang, Miri Kim, Baik Kee Cho, Hyun Jeong Park
BACKGROUND: Acquired ungual fibrokeratomas are uncommon fibrous tissue tumors located in the ungual area. Though there are many reports of this entity, only some reports have reviewed the clinical features of the tumor. AIMS: The aim of this study was to clarify the clinical characteristics of acquired ungual fibrokeratomas. METHODS: We reviewed twenty patients who were treated surgically at our clinic from 2003 to 2014 for acquired ungual fibrokeratomas confirmed on histopathological examination...
November 11, 2016: Indian Journal of Dermatology, Venereology and Leprology
Jung Min Bae, Kwang Hyun Choi, Han Mi Jung, Sook Young Kim, Miri Kim, Gyung Moon Kim, Dong Soo Yu, Young Bok Lee
BACKGROUND: Subsequent vitiligo after hematopoietic stem cell transplantation (HSCT) has been described sporadically in case series. OBJECTIVE: To investigate the incidence and risk factors of subsequent vitiligo after HSCT. METHODS: A nationwide, population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2009 to 2013. All HSCT recipients who had undergone HSCT between 2010 and 2011 and not treatment for vitiligo in 2009 (to exclude preexisting active vitiligo) were included in the HSCT recipient group, and an age- and sex-matched control group without HSCT was also established...
November 8, 2016: Journal of the American Academy of Dermatology
Hehe Cui, Na Li, Xiangdong Li, Kang Qi, Qing Li, Chen Jin, Tianjie Wang, Lian Duan, Leipei Jiang, Guihao Chen, Zhigang Wang, Cong Wei, Yuejin Yang
Cardiac microvascular endothelial cells (CMECs) extensively secrete cytokines during myocardial ischemia/reperfusion injury (MIRI). Tongxinluo (TXL) has been demonstrated to preserve the function of the endothelium and myocardium against MIRI. This study was designed to identify alterations in the paracrine function of CMECs under hypoxia/reoxygenation (H/R) conditions and assess its modulation by TXL. CMECs were exposed to different concentrations of TXL for 30 min and then subjected to hypoxia and reoxygenation for 12 and 2 h, respectively...
2016: American Journal of Translational Research
Yakir Rottenberg, Navah Z Ratzon, Miri Cohen, Ayala Hubert, Beatrice Uziely, Angela G E M de Boer
BACKGROUND: About half of colorectal patients are diagnosed less than 65 years of age and they have a relatively high cure rate. However, little is known about their employment and related risk factors. The aim of the current study was to clarify the association between colorectal cancer (CRC) and subsequent risk of being unemployed. METHODS: A historical prospective cohort study included baseline socio-demographic measurements of age, sex, ethnicity, residential socio-economic position and education from the 1995 Israeli National Census, cancer incidence between 2000 and 2007 and employment data between 1998 and 2011...
November 4, 2016: European Journal of Cancer
Alireza Ansari-Moghaddam, Hossein Ansari, Mahdi Mohammadi, Seyed Mehdi Tabatabaei, Mohammadreza Pishevare-Mofrad, Mahmodreza Miri-Bonjar
BACKGROUND: Although smoking and drug use are the major causes of accidents and death of drivers, few studies have been conducted on the prevalence of smoking and its associated factors in this occupational group. OBJECTIVES: The current study aimed to investigate the prevalence of smoking and its relationship with blood parameters among drivers in Zahedan city, Iran. PATIENTS AND METHODS: In this study, 1836 inner and intercity drivers were investigated in 2013 in terms of smoking and drug use and blood parameters...
September 2016: International Journal of High Risk Behaviors & Addiction
Chen Yang, Xiaojuan Liu, Fangfang Yang, Weixun Zhang, Zihao Chen, Daliang Yan, Qingsheng You, Xiang Wu
Phosphoglycerate mutase 5 (PGAM5) is a mitochondrial membrane protein that plays crucial roles in necroptosis and apoptosis. Though PGAM5 is known to be required for inducing intrinsic apoptosis through interacting with BCL2 associated X protein (Bax) and dynamin-related protein 1 (Drp1), the expression and role of PGAM5 in cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury(MIRI) has not been studied. The present study shows that PGAM5 expression decreased after MIRI in vivo, positively correlated with Bcl-xL expression, negatively correlated with Kelch-ECH associating protein 1 (Keap1) expression...
November 4, 2016: In Vitro Cellular & Developmental Biology. Animal
Satoshi Hayama, Kazuto Ohtaka, Yasuhito Shoji, Tatsunosuke Ichimura, Miri Fujita, Naoto Senmaru, Satoshi Hirano
BACKGROUND AND OBJECTIVES: Factors that contribute to difficult laparoscopic cholecystectomy (LC) in acute cholecystitis (AC) that would affect the performance of early surgery remain unclear. The purpose of this study was to identify such risk factors. METHODS: One hundred fifty-four patients who underwent LC for AC were retrospectively analyzed. The patients were categorized into early surgery and delayed surgery. Factors predicting difficult LC were analyzed for each group...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Ya Zhang, Changsheng Yuan, He Fang, Jia Li, Shanshan Su, Wen Chen
OBJECTIVES: This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (±dp/dtmax) were recorded. Cardiac injury was assessed by analyzing lactate dehydrogenase (LDH) and creatine kinase (CK) released in the coronary effluent...
September 2016: Iranian Journal of Basic Medical Sciences
Miri Kim, Kwang Hyun Choi, Se Won Hwang, Young Bok Lee, Hyun Jeong Park, Jung Min Bae
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract attributed to aberrant activity of the immune system. Increasing evidence suggests that patients with IBD are at an increased risk of inflammatory skin diseases (ISDs). OBJECTIVE: We sought to clarify the association between IBD and ISDs using a nationwide health claims database maintained in Korea. METHODS: We interrogated Korean health claim database data from 2009 to 2013...
October 25, 2016: Journal of the American Academy of Dermatology
Miri Krupkin, Itai Wekselman, Donna Matzov, Zohar Eyal, Yael Diskin Posner, Haim Rozenberg, Ella Zimmerman, Anat Bashan, Ada Yonath
Two structurally unique ribosomal antibiotics belonging to the orthosomycin family, avilamycin and evernimicin, possess activity against Enterococci, Staphylococci, and Streptococci, and other Gram-positive bacteria. Here, we describe the high-resolution crystal structures of the eubacterial large ribosomal subunit in complex with them. Their extended binding sites span the A-tRNA entrance corridor, thus inhibiting protein biosynthesis by blocking the binding site of the A-tRNA elbow, a mechanism not shared with other known antibiotics...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
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