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https://www.readbyqxmd.com/read/29340121/complications-of-transfusion-dependent-%C3%AE-thalassemia-patients-in-sistan-and-baluchistan-south-east-of-iran
#1
Maryam Yaghobi, Ebrahim Miri-Moghaddam, Naderi Majid, Ali Bazi, Ali Navidian, Asiyeh Kalkali
Background: Thalassemia syndromes are among prevalent hereditary disorders imposing high expenses on health-care system worldwide and in Iran. Organ failure represents a life-threatening challenge in transfusion- dependent β-thalassemia (TDT) patients. The purpose of the present study was to determine the frequency of organ dysfunctions among TDT patients in Sistan and Baluchistan province in South-East of Iran. Materials and Methods: Laboratory and clinical data were extracted from medical records as well as by interviews...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340072/hyperbaric-oxygen-protects-against-myocardial-reperfusion-injury-via-the-inhibition-of-inflammation-and-the-modulation-of-autophagy
#2
Chunxia Chen, Wan Chen, Yaoxuan Li, Yanling Dong, Xiaoming Teng, Zhihuan Nong, Xiaorong Pan, Liwen Lv, Ying Gao, Guangwei Wu
Our previous study demonstrated that hyperbaric oxygen (HBO) preconditioning protected against myocardial ischemia reperfusion injury (MIRI) and improved myocardial infarction. However, HBO's effect on MIRI-induced inflammation and autophagy remains unclear. In this study, we investigate the potential impact and underlying mechanism of HBO preconditioning on an MIRI-induced inflammatory response and autophagy using a ligation of the left anterior descending (LAD) coronary artery rat model. Our results showed that HBO restored myocardial enzyme levels and decreased the apoptosis of cardiomyocytes, which were induced by MIRI...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29334970/digital-media-based-health-intervention-on-the-promotion-of-women-s-physical-activity-a-quasi-experimental-study
#3
Nooshin Peyman, Majid Rezai-Rad, Hadi Tehrani, Mahdi Gholian-Aval, Mohammad Vahedian-Shahroodi, Hamid Heidarian Miri
BACKGROUND: Technological advances have caused poor mobility and lower physical activity among humankind. This study was conducted to assess the impact of a digital media-based (multi-media, internet, and mobile phone) health intervention on promotion of women's physical activity. METHODS: In this quasi-experimental study, 360 women were divided into case and control groups. The digital media-based educational intervention was conducted in two months in the case group electronically, using mail and Internet and telephone platforms...
January 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29329279/diosgenin-protects-rats-from-myocardial-inflammatory-injury-induced-by-ischemia-reperfusion
#4
Hong-Wei Wang, Hua-Jin Liu, Hua Cao, Zeng-Yong Qiao, Ya-Wei Xu
BACKGROUND Diosgenin, a phytosteroid sapogenin, has anti-inflammatory properties shown to reduce myocardial ischemia-reperfusion injury (MIRI). However, the specific mechanism by which this is achieved is not clear. This study investigated the protective effects of diosgenin on myocardial ischemia/reperfusion (I/R) and the potential anti-inflammatory mechanisms. MATERIAL AND METHODS Healthy adult male SD rats, body weight (b.w.) 250-280 g, were used to model ischemia-reperfusion injury (IRI) and were administered diosgenin (50 mg/kg and 100 mg/kg b...
January 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29328956/predicting-post-breakup-distress-and-growth-in-emerging-adulthood-the-roles-of-relationship-satisfaction-and-emotion-regulation
#5
Jerika C Norona, Miri Scharf, Deborah P Welsh, Shmuel Shulman
With a sample of emerging adults (N = 110; 72% female) this brief report utilized self-report measures to examine the role of relationship satisfaction and emotion regulation strategies assessed at age 20 in predicting breakup distress and posttraumatic growth three years later. Results showed that higher relationship satisfaction is associated with less future breakup distress. Emotion regulation explained the ways individuals cope with distress; cognitive appraisal (in contrast to emotional suppression) predicted higher growth after experiencing a breakup...
January 9, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29326049/quantitative-ct-assessment-of-gynecomastia-in-the-general-population-and-in-dialysis-cirrhotic-and-obese-patients
#6
Eyal Klang, Nayroz Kanana, Alon Grossman, Steve Raskin, Jana Pikovsky, Miri Sklair, Lior Heller, Shelly Soffer, Edith M Marom, Eli Konen, Marianne Michal Amitai
RATIONALE AND OBJECTIVES: Gynecomastia is the benign enlargement of the male breast because of proliferation of the glandular component. To date, there is no radiological definition of gynecomastia and no quantitative evaluation of breast glandular tissues in the general male population. The aims of this study were to supply radiological-based measurements of breast glandular tissue in the general male population, to quantitatively assess the prevalence of gynecomastia according to age by decades, and to evaluate associations between gynecomastia and obesity, cirrhosis, and dialysis...
January 8, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29313189/supportive-properties-of-basement-membrane-layer-of-human-amniotic-membrane-enable-development-of-tissue-engineering-applications
#7
Sonia Iranpour, Nasser Mahdavi-Shahri, Raheleh Miri, Halimeh Hasanzadeh, Hamid Reza Bidkhori, Hojjat Naderi-Meshkin, Ehsan Zahabi, Maryam M Matin
Human amniotic membrane (HAM) has been widely used as a natural scaffold in tissue engineering due to many of its unique biological properties such as providing growth factors, cytokines and tissue inhibitors of metalloproteinases. This study aimed at finding the most suitable and supportive layer of HAM as a delivery system for autologous or allogeneic cell transplantation. Three different layers of HAM were examined including basement membrane, epithelial and stromal layers. In order to prepare the basement membrane, de-epithelialization was performed using 0...
January 8, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29302847/a-green-non-acid-catalyzed-process-for-direct-n-n-c-group-formation-comprehensive-study-modeling-and-optimization
#8
Vahid Khakyzadeh, Mohammad Ali Zolfigol, Fatemeh Derakhshan-Panah, Majid Jafarian, Mir Vahid Miri, Maryam Gilandoust
The aim of this work is to introduce, model, and optimize a new non-acid-catalyzed system for a direct N[Formula: see text]N-C bond formation. By reacting naphthols or phenol with anilines in the presence of the sodium nitrite as nitrosonium ([Formula: see text] source and triethylammonium acetate (TEAA), a N[Formula: see text]N-C group can be formed in non-acid media. Modeling and optimization of the reaction conditions were investigated by response surface method. Sodium nitrite, TEAA, and water were chosen as variables, and reaction yield was also monitored...
January 4, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29290985/ophiobolin-a-kills-human-glioblastoma-cells-by-inducing-endoplasmic-reticulum-stress-via-disruption-of-thiol-proteostasis
#9
In Young Kim, MiRi Kwon, Min-Koo Choi, Dongjoo Lee, Dong Min Lee, Min Ji Seo, Kyeong Sook Choi
Ophiobolin A (OP-A), a fungal sesterterpene from Bipolaris oryzae, was recently shown to have anti-glioma activity. We show here that OP-A induces paraptosis-like cell death accompanied by dilation of the endoplasmic reticulum (ER) in glioma cells, and that CHOP-mediated ER stress plays a critical role in this process. OP-A-induced ER-derived dilation and cell death were found to be independent of reactive oxygen species, but were effectively blocked by various thiol antioxidants. We observed that OP-A can react with cysteinyl thiols to form Michael adducts, suggesting that the ability of OP-A to covalently modify free sulfhydryl groups on proteins may cause protein misfolding and the accumulation of misfolded proteins, leading to paraptosis-like cell death...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29287220/changes-in-rejection-sensitivity-across-adolescence-and-emerging-adulthood-associations-with-relationship-involvement-quality-and-coping
#10
Jerika C Norona, Valerya Tregubenko, Shira Bezalel Boiangiu, Gil Levy, Miri Scharf, Deborah P Welsh, Shmuel Shulman
Using a sample of 110 Israeli youth (72% female), the present study investigates associations between initial levels of rejection sensitivity as well as changes in rejection sensitivity from age 16 to age 23 and relationship involvement, quality, and (growth following) coping with relationship stress. Results showed that rejection sensitivity generally decreased over time into the transition to adulthood. Furthermore, levels of rejection sensitivity at age 16 predicted whether young people were romantically involved by age 23, as well as the quality of their relationships...
December 26, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/29284150/men-main-victims-of-hidradenitis-suppurativa-a-prospective-cohort-study
#11
Hemmat Maghsoudi, Hojjat Almasi, Mahmood Reza Miri Bonjar
BACKGROUND: hidradenitis suppurativa (HS) is a chronic inflammatory disease presenting as painful subcutaneous nodules, characterized by multiple abscess, inter-networking sinus tracts. We present the option of surgical treatment involving wide surgical excision and methods of reconstruction as well as the rate of recurrence. METHOD: This study reviewed 44 sites in 21 patients with moderate to extensive HS treated surgically in our hospital from 2000 to 2016, with a follow up of at least 24 months...
December 25, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29280369/characteristics-of-the-regional-human-milk-bank-in-poland-donors-recipients-and-nutritional-value-of-human-milk
#12
Olga Barbarska, Monika Zielińska, Beata Pawlus, Aleksandra Wesołowska
Background: In case of shortage of breast milk despite proper lactation care or the poor state of the mother’s health, breast milk from human milk bank is recommended for feeding preterm infants Objective: This study retrospectively evaluated the first year of the operation of the Regional Human Milk Bank Material and methods: Data concerning donors was collected in the human milk bank during the cooperation. The clinical characteristics of the recipients was made on the basis of medical documentation from the Holy Family Hospital in Warsaw, Poland...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29279058/the-effect-of-omalizumab-treatment-on-the-low-affinity-immunoglobulin-e-receptor-cd23-fc-epsilon-rii-in-patients-with-severe-allergic-asthma
#13
Miri Assayag, Shabtai Moshel, Martin Kohan, Neville Berkman
BACKGROUND: Omalizumab is an anti-immunoglobulin E (IgE) monoclonal antibody used in the treatment of severe asthma. Its therapeutic efficacy is primarily attributed to reduction of serum-free IgE and in the expression of high-affinity IgE receptor, fc epsilon RI. However, its effect on the low-affinity IgE receptor fc epsilon RII/CD23 in vivo has not been evaluated. AIM: To determine whether CD23 plays a role in the inflammatory process in severe uncontrolled asthma and whether anti-IgE therapy modulates fc epsilon RII/CD23 expression in these patients...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29273831/synergism-between-apolipoprotein-e-%C3%A6-4-allele-and-paraoxonase-pon1-55-m-allele-is-associated-with-risk-of-systemic-lupus-erythematosus
#14
Maryam Tanhapour, Ali Miri, Asad Vaisi-Raygani, Fariborz Bahrehmand, Amir Kiani, Zohreh Rahimi, Tayebeh Pourmotabbed, Ebrahim Shakiba
Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met < Leu) allele genes lead to disorders in lipid metabolism and are related to atherosclerosis. This study is the first investigation to examine the possible association between ApoE and PON1-L55M polymorphisms and correlation with serum arylesterase (ARE) activities of PON, levels of malondialdehyde (MDA), neopterin, and lipid lipoprotein in SLE patients from Iranian western population...
December 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29273206/cardiovascular-health-and-cognitive-decline-2-decades-later-in-men-with-preexisting-coronary-artery-disease
#15
Miri Lutski, Galit Weinstein, Uri Goldbourt, David Tanne
Cardiovascular health (CVH) factors are associated with lower risk of cardiovascular disease, stroke, and mortality. We investigated the association between a modified CVH metrics score and change in cognitive functions 2 decades later in patients with pre-existing coronary artery disease. A subset of 200 men (mean age at baseline 57.3 ± 6.3 years) who previously participated in a secondary prevention trial (1990 to 1997) underwent cognitive evaluation 14.6 ± 1.9 years after baseline (mean age 72...
November 23, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29245482/new-taxa-and-new-records-of-butterflies-lepidoptera-pieridae-lycaenidae-nymphalidae-from-afghanistan
#16
Vadim Tshikolovets
Three new species Karanasa naumanni sp. nov., K. pardesi sp. nov. and K. pseudopamira sp. nov. (Nymphalidae), two new subspecies Karanasa pamira biocellata subsp. nov. (Nymphalidae) and Plebejus (Afarsia) sieversii albolunulatus subsp. nov. (Lycaenidae) are described from Afghanistan. First occurrence records for this country are presented for 26 species: one species of Pieridae (Colias thisoa), fifteen species of Lycaenidae (Deudoryx epijarbas, Everes dipora, Glaucopsyche charybdis, Hyrcanana evansii, Iolana gigantea, Lycaena kasyapa, Plebejus ferganus, Polyommatus amandus, P...
November 28, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245467/revision-of-the-genus-i-leptogomphus-i-selys-in-borneo-including-gene-trees-and-a-two-marker-molecular-phylogeny-odonata-anisoptera-gomphidae
#17
Rory A Dow, Frank Stokvis, Robin W J Ngiam
The Bornean members of the genus Leptogomphus Selys are revised. Two new species are described: Leptogomphus schieli sp. nov. (holotype ♂, Gunung Penrissen, Kuching Division, Sarawak, Malaysia, to be deposited in BMNH) and Leptogomphus sii sp. nov. (holotype ♂, Sungai Sii, upper Baram, Miri Division, Sarawak, Malaysia, in RMNH). Leptogomphus mariae Lieftinck, 1948 is considered to be a junior synonym of L. coomansi Laidlaw, 1936. The true male of L. pasia van Tol, 1990 is described for the first time; male specimens previously treated as L...
November 29, 2017: Zootaxa
https://www.readbyqxmd.com/read/29242986/pre-and-postconditioning-the-heart-with-hydrogen-sulfide-h2s-against-ischemia-reperfusion-injury-in-vivo-a-systematic-review-and-meta-analysis
#18
REVIEW
Qutuba G Karwi, Justin S Bice, Gary F Baxter
Conditioning-like infarct limitation by enhanced level of hydrogen sulfide (H2S) has been demonstrated in many animal models of myocardial ischemia/reperfusion injury (MIRI) in vivo. We sought to evaluate the effect of H2S on myocardial infarction across in vivo pre-clinical studies of MIRI using a comprehensive systematic review followed by meta-analysis. Embase, Pubmed and Web of Science were searched for pre-clinical investigation of the effect of H2S on MIRI in vivo. Retained records (6031) were subjected to our pre-defined inclusion criteria then were objectively critiqued...
December 14, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29241791/decreased-risk-of-vitiligo-in-organ-transplant-recipients-a-population-based-cohort-study
#19
Jung Min Bae, Kwang Hyun Choi, Jin Young Choi, Miri Kim, Gyung Moon Kim, Dong Soo Yu, Young Bok Lee
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29239861/capacitance-voltage-analysis-of-electrical-properties-for-wse2-field-effect-transistors-with-high-k-encapsulation-layer
#20
Seung-Pil Ko, Jong Mok Shin, Ho-Kyun Jang, Min Youl You, Jun-Eon Jin, Miri Choi, Jiung Cho, Gyu-Tae Kim
Doping effects in devices based on two-dimensional materials have been widely studied. However, detailed analysis and mechanism of the doping effect caused by encapsulation layers has not been sufficiently explored. In this work, we present experimental studies on the n-doping effect in WSe2 field effect transistors (FETs) with high-k encapsulation layer (Al2O3) grown by atomic layer deposition (ALD). In addition, we demonstrate the mechanism and origin of the doping effect. After encapsulation of the Al2O3 layer, the threshold voltage of the WSe2 FET negatively shifted with the increase of the on-current...
December 14, 2017: Nanotechnology
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