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Ali Abdolahnejad, Negar Jafari, Amir Mohammadi, Mohammad Miri, Yaghoub Hajizadeh
Background: The presence of air pollutants such as CO, NO2 , SO2 , O3 , and PM in the ambient air mainly emitted from fossil fuels combustion has become a major health concern. The aims of this study were to estimate the attribution of NO2 , SO2 , and O3 in the premature deaths and prevalence of cardiovascular and respiratory diseases in Isfahan in 2013-2014. Methods: In this study, short-term health effects (total mortality, cardiovascular and respiratory mortality, chronic obstructive pulmonary disease, and acute myocardial infarction) of exposure NO2 , SO2 , and O3 on the population of Isfahan were assessed using AirQ 2...
2018: International Journal of Preventive Medicine
Cheng Zeng, Wen Jiang, Ruifang Zheng, Chenghui He, Jianguang Li, Jianguo Xing
Our previous research demonstrated that tilianin protects the myocardium in a myocardial ischemia reperfusion injury (MIRI) rat model and has prominent pharmacological potential as a cardiovascular drug. Our study aimed to investigate the molecular signaling implicated in the improvement of myocardial survival induced by tilianin, a flavonoid antioxidant. Tilianin (2.5, 5, and 10 mg/kg/d) or saline was orally administered to rats for 14 days. On the 15th day, ischemia was induced by ligating the left anterior descending artery for 45 min, followed by 4 h of reperfusion...
2018: PloS One
Miri Park, Jaeho Song, Gi Gyun Nam, Suhyun Kim, Yochan Joung, Jang-Cheon Cho
A bacterial strain, designated IMCC25901T , was isolated from a freshwater lake, Soyang, in the Republic of Korea. The strain was Gram-stain-negative, aerobic, non-motile, orange-coloured and short rod-shaped. The 16S rRNA gene sequence analysis showed that strain IMCC25901T was most closely related to Flavobacterium yonginense HMD1001T (97.0 %) and formed a robust phylogenetic clade with other species of the genus Flavobacterium. Growth of strain IMCC25901T was observed at 10-30 °C (optimum, 20 °C), pH 6-8 (optimum, pH 7) and 0-1...
March 14, 2018: International Journal of Systematic and Evolutionary Microbiology
Azadeh Arbabi Sabzevari, Morteza Miri, Tayeb Raziei, Hassan Oroji, Mojtaba Rahimi
The present study aims to evaluate the influence of climate conditions on tourism in the port of Chabahar, southeastern Iran, using the climate comfort indices (CIT, PMV, and TCI) and the field data relative to the tourist satisfaction. According to the computed TCI, the autumn-winter season (October-April) is climatically favorable for tourism in Chabahar, but it is ideal during January to March. Based on the computed PMV index, the studied region is in the range of climate comfort in most parts of the year...
March 14, 2018: International Journal of Biometeorology
Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar
Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to its ability to establish latent infection, with one characterized viral reservoir being hematopoietic cells. Although reactivation from latency causes serious disease in immunocompromised individuals, our molecular understanding of latency is limited. Here, we delineate viral gene expression during natural HCMV persistent infection by analyzing the massive transcriptome RNA sequencing (RNA-seq) atlas generated by the Genotype-Tissue Expression (GTEx) project...
March 13, 2018: MBio
Youngil Kwon, Hyunjung Ko, Soojung Kim, Miri Kim
BACKGROUND/AIM: Continuous research efforts have been focusing on promoting healing of delayed replantation of avulsed teeth. The aim of this in vivo study was to assess the effect of cathepsin K inhibitor surface treatment on delayed tooth replantation.Materials and Methods Thirty-four premolar roots of four beagle dogs were extracted and conventional root canal treatment was performed. The canals were filled with gutta-percha and cement. All extracted teeth were air-dried for 1 h. Teeth were divided into two groups according to the root surface treatment prior to replantation: control (n = 13) and cathepsin K inhibitor (n = 21)...
March 13, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Mohammad Sahebkar, Hamid Miri Heidarian, Pardis Noormohammadpour, Rahim Akrami, Nasrin Mansournia, Bahareh Tavana, Mohammad Ali Mansournia, Emmanuel Stamatakis
OBJECTIVE: To assess the prevalence and correlates of low physical activity among Iranian population aged 15-64 years. METHODS: We used the data collected in National Surveillance of Risk Factors of Non-Communicable Diseases in Iran, 2011. Physical activity was categorized in 3 levels of low, moderate, and high based on a Persian version of Global Physical Activity Questionnaire. The multistage cluster sampling design was accounted for using complex survey analysis method...
March 12, 2018: Scandinavian Journal of Medicine & Science in Sports
Navroop K Dhaliwal, Kamelia Miri, Scott Davidson, Hala Tamim El Jarkass, Jennifer A Mitchell
Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency, KLF4 protein is exported from the nucleus causing rapid decline in Nanog and Klf4 transcription; as a result, KLF4 is the first pluripotency transcription factor removed from transcription-associated complexes during differentiation...
March 1, 2018: Stem Cell Reports
Miry Shim, Sara Yang, Catherine R Messina, Jonathan P Mintzer
PURPOSE: To compare discharge breastmilk feeding rates among asymptomatic term newborns receiving 48-hour versus >48-hour antibiotics in the neonatal intensive care unit (NICU) and a cohort of well-baby nursery (WBN) newborns. MATERIALS AND METHODS: This retrospective review included asymptomatic term neonates admitted to the NICU due to maternal chorioamnionitis and a comparison group of WBN neonates between January 2012 and December 2015. Demographic, birth, feeding, and lactation consultant visit data were analyzed in univariate and multivariate models...
March 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
Miri Na, Aeri Yoo
PURPOSE: To evaluate the effectiveness of the orthokeratology (OK) lens slowing myopic progression compared with no intervention in pediatric eyes METHODS: A retrospective review of medical records was performed on 45 monocular myopic subjects 7 to 13 years of age who were treated with monocular ortho-k lens and followed-up for more than 12 months. The monocular myopia in the subjects' eyes was -0.75 to -4.25 D (diopter), and near emmetropia in the contralateral and with-the-rule astigmatism no greater than -1...
March 9, 2018: Japanese Journal of Ophthalmology
Jun Yang, Chaojun Yang, Jian Yang, Jiawang Ding, Xinxin Li, Qinqin Yu, Xin Guo, Zhixing Fan, Huibo Wang
The Toll-like receptor 4 (TLR4) signal pathway- induced inflammation is considered to be a crucial link to myocardial ischemia reperfusion injury (MIRI). Our previous study proved that radioprotective 105 kDa protein (RP105), a negative regulator of TLR4, performed a protective role in MIRI by anti-apoptosis approach. However, the mechanism of RP105 cardioprotection of anti-inflammation is still unclear. This study aimed to explore the underlying mechanism of RP105 anti-inflammation effect in MIRI. We established a rat model of MIRI induced by ligation of the left anterior descending coronary artery for 30 min followed by 2 h reperfusion...
March 6, 2018: International Journal of Molecular Medicine
Mansooreh Dehghani, Mehdi Fazlzadeh, Armin Sorooshian, Hamid Reza Tabatabaee, Mohammad Miri, Abbas Norouzian Baghani, Mahdieh Delikhoon, Amir Hossein Mahvi, Majid Rashidi
This study reports a spatiotemporal characterization of toluene, benzene, ethylbenzene, and xylenes concentrations (BTEX) in an urban hot spot in Iran, specifically at an bus terminal region in Shiraz. Sampling was carried out according to NIOSH Compendium Method 1501. The inverse distance weighting (IDW) method was applied for spatial mapping. The Monte Carlo simulation technique was applied to evaluate carcinogenic and non-carcinogenic risk owing to BTEX exposure. The highest average BTEX concentrations were observed for benzene in the morning (at 7:00-9:00 A...
March 3, 2018: Ecotoxicology and Environmental Safety
Miri Park, Jaeho Song, Gi Gyun Nam, Yochan Joung, Lei Zhao, Min-Kyu Kim, Jang-Cheon Cho
A Gram-stain-negative, pink-coloured, non-motile and gamma radiation-resistant bacterium, designated strain IMCC1711T , was isolated from a freshwater sample collected from an artificial pond (Inkyong Pond). The 16S rRNA gene sequence analysis showed that strain IMCC1711T was most closely related to Deinococcus piscis 3axT (94.2 %) and formed a robust phylogenetic clade with other species of the genus Deinococcus. Optimal growth of strain MCC1711T was observed at 25 °C and pH 7.0 without NaCl. Strain IMCC1711T exhibited high resistance to gamma radiation...
March 5, 2018: International Journal of Systematic and Evolutionary Microbiology
Miri Kestler-Peleg, Osnat Lavenda
The present study examines a mother's perception of her pregnancy as risking herself and her fetus, as a mediator of the association between depressive symptoms during pregnancy and depressive symptoms 5 years after giving birth, regardless of actual objective risk. 290 Jewish Israeli mothers filled out self-reported questionnaires dealing with objective risk, subjective risk and depressive symptoms. The findings confirmed partial mediation effect, implying a potential negative impact of the preventive efforts usually made, by increasing risk perception with long-term costs for mothers, especially for those who have already developed depressive symptoms...
February 23, 2018: Psychiatry Research
Xiufen Li, Aishan Bilali, Rui Qiao, Tuerxun Paerhati, Yan Yang
Myocardial ischemia/reperfusion injury (MIRI) induces severe arrhythmias and has a high risk of mortality. The aim of the present study was to investigate the effect of tacrolimus on arrhythmias, cardiac function, oxidative stress and myocardium apoptosis induced by MIRI, and to elucidate the underlying mechanism. The effects of MIRI and tacrolimus on arrhythmias, cardiac function parameters, myocardial oxidative stress and apoptosis were investigated in a rat model of MIRI. The phosphorylation of peroxisome proliferator‑activated receptor γ (PPARγ) and protein kinase B (Akt) was investigated via western blotting...
February 27, 2018: Molecular Medicine Reports
Sareh Eghtesad, Zahra Mohammadi, Amaneh Shayanrad, Elnaz Faramarzi, Farahnaz Joukar, Behrooz Hamzeh, Mojtaba Farjam, Mohammad Javad Zare Sakhvidi, Mohammadreza Miri-Monjar, Mahmood Moosazadeh, Hamid Hakimi, Salar Rahimi Kazerooni, Bahman Cheraghian, Ali Ahmadi, Azim Nejatizadeh, Iraj Mohebbi, Farhad Pourfarzi, Farzin Roozafzai, Nazgol Motamed-Gorji, Seyed Ali Montazeri, Sahar Masoudi, Masoumeh Amin-Esmaeili, Navid Danaie, Seyed Reza Mirhafez, Hasan Hashemi, Hossein Poustchi, Reza Malekzadeh
In the past, communicable diseases caused the highest mortality in Iran. Improvements in socioeconomic status and living standards including access to safe drinking water, along with the inception of Health Houses in the 1980s, have changed disease patterns, decreasing the spread of and deaths from infectious and communicable diseases. The incidence and prevalence of non-communicable diseases (NCD), however, have now increased in Iran, accounting for nearly 80% of deaths and disabilities. Without interventions, NCD are predicted to impose a substantial human and economic burden in the next 2 decades...
November 1, 2017: Archives of Iranian Medicine
Mitsuya Yamakita, Miri Sato, Kohta Suzuki, Daisuke Ando, Zentaro Yamagata
BACKGROUND: Lower birth weight (BW) is associated with increased chronic disease risk later in life. Previous studies suggest that this may be mediated principally via physical activity (PA). However, the association between BW and PA in children has not been clarified. The purpose of this study was to examine the association between BW and PA in school-aged children in Japan. METHODS: Participants were children from a prospective birth cohort study (Project Koshu) who were born from 1996 through 2002 in rural Japan...
February 24, 2018: Journal of Epidemiology
Emily Griswold, Thomas Unnasch, Mark Eberhard, Bertram E B Nwoke, Zoraida Morales, Edridah Muheki Tukahebwa, Biruck Kebede, Ifeoma Anagbogu, Moses Katabarwa, Peace Habomugisha, Zerihun Tadesse, Emmanuel S Miri, Darin Evans, Daniel Cohn, Elizabeth Elhassan, Frank Richards
National onchocerciasis elimination committees (NOECs) serve to help ministries of health complete the pathway to successful verification of elimination of onchocerciasis (river blindness), as outlined in the 2016 World Health Organization guidelines. These guidelines, however, only take effect when the country believes it has reached a point that elimination can be demonstrated, and do not address the preceding milestones. Therefore, NOECs can be of great help with guiding and tailoring earlier planning, programming and assessments to empower national programs to aggressively move toward their countries' elimination goals...
March 1, 2018: International Health
Yukari Suda, Naoko Kuzumaki, Takefumi Sone, Michiko Narita, Kenichi Tanaka, Yusuke Hamada, Chizuru Iwasawa, Masahiro Shibasaki, Aya Maekawa, Miri Matsuo, Wado Akamatsu, Nobutaka Hattori, Hideyuki Okano, Minoru Narita
Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites including the substantia nigra pars compacta (SNc), which is related to phenotypic dysregulation or frank degeneration in Parkinson's disease (PD). Here we found a dramatic decrease in the expression of GHSR in PD-specific induced pluripotent stem cell (iPSC)-derived dopaminergic (DAnergic) neurons generated from patients carrying parkin gene (PARK2) mutations compared to those from healthy controls...
February 20, 2018: Molecular Brain
Anastasya Birger, Miri Ottolenghi, Liat Perez, Benjamin Reubinoff, Oded Behar
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by cell death of upper and lower motor neurons (MNs). The cause of MN cell loss is not completely understood but involves both cell autonomous and non-cell autonomous mechanisms. Numerous molecules have been implicated to be involved in the death of MNs. One such candidate is semaphorin 3A (Sema3A). In ALS patients, Sema3A was shown to be significantly upregulated in the motor cortex and downregulated in the spinal cord. In the mouse, Sema3A was shown to be an axon repellent molecule for MNs...
February 15, 2018: Cell Death & Disease
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