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https://www.readbyqxmd.com/read/28625317/sphingosine-1-phosphate-postconditioning-protects-against-myocardial-ischemia-reperfusion-injury-in-rats-via-mitochondrial-signaling-and-akt-gsk3%C3%AE-phosphorylation
#1
Rui Fang, Lu-Lu Zhang, Li-Zhi Zhang, Wenchang Li, Mengmeng Li, Ke Wen
BACKGROUND AND AIMS: Although preconditioning of sphingosine 1-phosphate (S1P) has been shown to protect myocytes from hypoxia reoxgenation injury in vitro, the role of S1P postconditioning on myocardial ischemia reperfusion injury (MIRI) in vivo and its related mechanism are unknown. The aim of this study was to investigate the protective role of sphingosine 1-phosphate (S1P) postconditioning in MIRI via its effects on mitochondrial signaling and Akt/Gsk3β phosphorylation. METHODS: Rats were subjected to MIRI, consisting of 30 min of ischemia followed by 120 min of reperfusion, with S1P administered at the beginning of the reperfusion...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28620870/severe-growth-deficiency-microcephaly-intellectual-disability-and-characteristic-facial-features-are-due-to-a-homozygous-qars-mutation
#2
Esther Leshinsky-Silver, Jiqiang Ling, Jiang Wu, Chana Vinkler, Keren Yosovich, Sarit Bahar, Miri Yanoov-Sharav, Tally Lerman-Sagie, Dorit Lev
Glutaminyl tRNA synthase is highly expressed in the developing fetal human brain. Mutations in the glutaminyl-tRNA synthetase (QARS) gene have been reported in patients with progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. We have previously reported a new recessive syndrome of severe linear growth retardation, poor weight gain, microcephaly, characteristic facial features, cutaneous syndactyly of the toes, high myopia, and intellectual disability in two sisters of Ashkenazi-Jewish origin (Eur J Med Genet 2014;57(6):288-92)...
June 15, 2017: Neurogenetics
https://www.readbyqxmd.com/read/28620775/normalization-as-a-strategy-for-maintaining-quality-of-life-while-coping-with-infertility-in-a-pronatalist-culture
#3
Yael Benyamini, Miri Gozlan, Ariel Weissman
PURPOSE: Infertility could be highly stressful, particularly in a pronatalist culture. We aimed to develop the concept and a measure of normalization (maintaining normal life routines and feeling "normal") as a strategy that could enable women with infertility maintain their quality of life (QoL) while coping with this condition. We tested its associations with women's well-being, distress and QoL in Israel, where being childless is socially unacceptable and highly stigmatized. METHODS: One-hundred and eighty Israeli women undergoing infertility treatment at a fertility community clinic filled in questionnaires assessing normalization-related coping strategies, QoL, and psychological adjustment (distress, wellbeing)...
June 15, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28615844/the-antileishmanial-effects-of-lowsonia-inermis-and-cedrus-libani-on-leishmania-major-promastigotes-an-in-vitro-study
#4
Mohammad Hossein Motazedian, Fattaneh Mikaeili, Mehdi Mohebali, Ramin Miri, Parvaneh Habibi, Sakineh Kamarloie
Leishmaniasis is a parasitic disease caused by different species of protozoan parasites belonging to the genus Leishmania. In this study, Leishmania major (MRHO/IR/75/ER) promastigotes were cultured at 23-25 °C in brain heart infusion (BHI) medium supplemented with 10 % heat-inactivated fetal bovine serum (FBS) and penicillin and streptomycin. Antileishmanial effects of Lowsonia inermis and Cedrus libani methanolic extracts (0.07, 0.15, 0.31, 0.62, 1.25, 2.5, 5, 10 mg/mL) on Leishmania major promastigotes were evaluated using the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28612268/discordant-sleep-parameters-among-actigraphy-polysomnography-and-perceived-sleep-in-patients-with-sleep-disordered-breathing-in-comparison-with-patients-with-chronic-insomnia-disorder
#5
Su Jung Choi, Miri Kang, Min Je Sung, Eun Yeon Joo
PURPOSE: Although the clinical usefulness of actigraphy (ACT) in chronic insomnia disorder (CID) is extensively investigated, the evaluation on the utility of ACT in sleep-disordered breathing (SDB) is limited and the report of comparison with perceived sleep by patients and polysomnography (PSG) is scarce. METHODS: Thirty-six patients with SDB and 30 with CID underwent PSG and ACT, and they reported perceived sleep time and latency simultaneously. Sleep parameters (total sleep time [TST], sleep onset latency [SOL], sleep efficiency, and wakefulness after sleep onset [WASO]) were compared...
June 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28610404/effects-of-tobacco-on-salivary-antioxidative-and-immunologic-systems
#6
Fateme Arbabi-Kalati, Saeede Salimi, Saeede Nabavi, Sahebdad Rigi, Masoud Miri-Moghaddam
Background: Tobacco use is a harmful habit that causes adverse effects on oral health and plays a most important role in cancer development. Saliva is the first fluid that is exposed to tobacco and its antioxidant system plays an important role in anti-cancer potential; therefore, this study was designed to compare the antioxidant activity and immunologic system of saliva in tobacco users (smokers and smokeless tobacco users) and non-users. Materials and Methods: In this cross-sectional study, unstimulated saliva samples of 75 healthy individuals from three equal groups were investigated...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28597598/rosa-rugosa-flavonoids-alleviate-myocardial-ischemia-reperfusion-injury-in-mice-by-suppressing-jnk-and-p38-mapk
#7
Xuehui Zhang, Yuhui Wang, Wanli Shen, Shangzhi Ma, Wen Chen, Rong Qi
OBJECTIVE: Although Rosa rugosa has been applied for preventing coronary artery disease, the pharmacological mechanism is little explored. In this study, the effects and mechanisms of Rosa rugosa flavonoids (RRF) on myocardial ischemia reperfusion injury (MIRI) were investigated. METHODS: Mice were pretreated by intragastric administration of 600 mg/kg RRF for 7 days. Then MIRI was induced by 45 min coronary artery ligation and 3 h reperfusion. Myocardial infarct size (MIS) and histopathology, activities of myocardial enzymes and effects of RRF on inflammation and apoptosis were evaluated...
June 9, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28591367/myocardial-ischemic-post-conditioning-protects-the-lung-against-myocardial-ischemia-reperfusion-induced-damage-by-activating-gsk-3%C3%AE
#8
Wenwei Gao, Bo Zhao, Lian Liu, Quan Yuan, Xiaojing Wu, Zhongyuan Xia
Purpose: To investigate whether modulating GSK-3β could attenuate myocardial ischemia reperfusion injury (MIRI) induced acute lung injury (ALI) and analyze the underlying mechanism. Methods: Male SD rats were subjected to MIRI with or without myocardial ischemic post-conditioning in the presence or absence of GSK-3β inhibitor. GSK-3β inhibitor was injected peritoneally 10min before MIRI. Lung W/D weight ratio, MPO, PMNs, histopathological changes, TUNEL, Bax, Bcl-2, IL-6, IL-8, IL-10, GSK-3β, and caspase-3 were evaluated in the lung tissues of all rats...
May 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28584458/epidemiology-of-rotavirus-in-the-iranian-children-a-systematic-review-and-meta-analysis
#9
REVIEW
Seyed Hamid Reza Monavari, Shima Hadifar, Shayan Mostafaei, Ali Miri, Mohsen Keshavarz, Farhad Babaei, Mohsen Moghoofei
Rotavirus is associated with increased risk for severe diarrhea in infants and young children worldwide. This systematic review and meta-analysis was performed to determine the prevalence rate of rotavirus from different parts of Iran and provide an overall relative frequency (RF) for Iran. We performed a systematic literature review from several databases including PubMed, ISI Web of Science, Scopus, OVID, MAG IRAN, IranMedex, and Iranian Scientific Information Database. We searched the following keywords: "rotavirus," "rotavirus infection," "acute gastroenteritis," "diarrhea," "children," "infant," and "Iran...
April 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28580013/a-comparative-study-of-anaerobic-fixed-film-baffled-reactor-and-up-flow-anaerobic-fixed-film-fixed-bed-reactor-for-biological-removal-of-diethyl-phthalate-from-wastewater-a-performance-kinetic-biogas-and-metabolic-pathway-study
#10
Samira Yousefzadeh, Ehsan Ahmadi, Mitra Gholami, Hamid Reza Ghaffari, Ali Azari, Mohsen Ansari, Mohammad Miri, Kiomars Sharafi, Soheila Rezaei
BACKGROUND: Phthalic acid esters, including diethyl phthalate (DEP), which are considered as top-priority and hazardous pollutants, have received significant attention over the last decades. It is vital for industries to select the best treatment technology, especially when the DEP concentration in wastewater is high. Meanwhile, anaerobic biofilm-based reactors are considered as a promising option. Therefore, in the present study, for the biological removal of DEP from synthetic wastewater, two different anaerobic biofilm-based reactors, including anaerobic fixed film baffled reactor (AnFFBR) and up-flow anaerobic fixed film fixed bed reactor (UAnFFFBR), were compared from kinetic and performance standpoints...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28570395/runs-of-homozygosity-copy-number-variation-and-risk-for-depression-and-suicidal-behavior-in-an-arab-bedouin-kindred
#11
Nadine M Melhem, Sami Hamdan, Lambertus Klei, Shawn Wood, Jamie Zelazny, Amos Frisch, Abraham Weizman, Miri Carmel, Elena Michaelovsky, Ilana Farbstein, Danuta Wasserman, Muhammad El-Heib, Robert Ferrell, Alan Apter, Bernie Devlin, David Brent
OBJECTIVES: Inbreeding increases the probability of homozygosity of deleterious alleles. Inbreeding and runs of homozygosity (ROH) are associated with an increased risk for disease phenotypes, including schizophrenia and other psychiatric disorders. The effects of inbreeding, ROH, homozygous deletions, and other copy number variations (CNVs) on risk for depression and suicide attempt (SA) were quantified in an Arab Bedouin Kindred. METHODS: We carried out genetic analyses of 439 individuals from an Arab kindred with high rates of depression and suicidal behavior...
May 31, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28559357/bone-marrow-failure-unresponsive-to-bone-marrow-transplant-is-caused-by-mutations-in-thpo
#12
Aaron Seo, Miri Ben-Harosh, Mehtap Sirin, Jerry Stein, Orly Dgany, Joseph Kaplelushnik, Manfred Hoenig, Ulrich Pannicke, Myriam Lorenz, Klaus Schwarz, Clemens Stockklausner, Tom Walsh, Suleyman Gulsuner, Ming K Lee, Anoop Sendamarai, Marilyn Sanchez-Bonilla, Mary-Claire King, Holger Cario, Andreas E Kulozik, Klaus-Michael Debatin, Ansgar Schulz, Hannah Tamary, Akiko Shimamura
We report 5 individuals in 3 unrelated families with severe thrombocytopenia progressing to trilineage bone marrow failure (BMF). Four of the children received hematopoietic stem cell transplants and all showed poor graft function with persistent severe cytopenias even after repeated transplants with different donors. Exome and targeted sequencing identified mutations in the gene encoding thrombopoietin (THPO): THPO R99W, homozygous in affected children in two families and THPO R157X, homozygous in the affected child in the third family...
May 30, 2017: Blood
https://www.readbyqxmd.com/read/28557650/a-pilot-study-of-the-efficacy-of-the-polargen-%C3%A2-ultrahigh-frequency-electric-field-40-68-mhz-radiofrequency-device-in-the-treatment-of-facial-contouring
#13
Miri Kim, Jihong Lim, Jung Min Bae, Hyun Jeong Park
BACKGROUND: Various radiofrequency (RF) devices are used to treat skin laxity and for face contouring, but few studies have examined ultrahigh-frequency (UHF) electric field (40.68 MHz) RF devices. OBJECTIVE: To evaluate the efficacy and safety of a UHF electric field (40.68 MHz) RF device for skin tightening and face contouring. METHODS: Ten patients each underwent four sessions of UHF electric field RF device treatment at 2-week intervals...
May 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28555396/human-health-impact-assessment-of-exposure-to-particulate-matter-an-airq-software-modeling
#14
Mohammad Miri, Hamideh Ebrahimi Aval, Mohammad Hassan Ehrampoush, Amir Mohammadi, Ali Toolabi, Ali Nikonahad, Zahra Derakhshan, Ali Abdollahnejad
The aim of this study was to assess the health impacts related to particulate matter less than 10 μm (PM10) exposure in the city of Yazd, Iran. For this aim, AirQ 2.2.3 software was used to model relationship between short-term exposure to PM10 and disease cases proposed by the World Health Organization (WHO). The annual mean concentration of PM10 was 97 μg/m(3). The maximum concentration value of PM10 was measured during the summer (731 μg/m(3)). 4.988% (95%CI: 3.381-6.542%) of the total mortality, 7...
May 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28553578/a-comprehensive-study-of-retinal-vessel-classification-methods-in-fundus-images
#15
REVIEW
Maliheh Miri, Zahra Amini, Hossein Rabbani, Raheleh Kafieh
Nowadays, it is obvious that there is a relationship between changes in the retinal vessel structure and diseases such as diabetic, hypertension, stroke, and the other cardiovascular diseases in adults as well as retinopathy of prematurity in infants. Retinal fundus images provide non-invasive visualization of the retinal vessel structure. Applying image processing techniques in the study of digital color fundus photographs and analyzing their vasculature is a reliable approach for early diagnosis of the aforementioned diseases...
April 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28547766/local-release-of-vegf-using-fiber-mats-enables-effective-transplantation-of-layered-cardiomyocyte-sheets
#16
Kenichi Nagase, Yuhei Nagumo, Miri Kim, Hee-Jung Kim, Hei-Won Kyung, Hye-Jin Chung, Hidekazu Sekine, Tatsuya Shimizu, Hideko Kanazawa, Teruo Okano, Seung-Jin Lee, Masayuki Yamato
Cell sheet transplantation is a key tissue engineering technology. A vascular endothelial growth factor (VEGF)-releasing fiber mat is developed for the transplantation of multilayered cardiomyocyte sheets. Poly(vinyl alcohol) fiber mats bearing poly(lactic-co-glycolic acid) nanoparticles that incorporate VEGF are fabricated using electrospinning and electrospray methods. Six-layered cardiomyocyte sheets are transplanted with a VEGF-releasing mat into athymic rats. After two weeks, these sheets produce thicker cardiomyocyte layers compared with controls lacking a VEGF-releasing mat, and incorporate larger-diameter blood vessels containing erythrocytes...
May 26, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28530313/-minimally-invasive-parathyroidectomy-mip-under-local-anesthesia-for-treatment-of-primary-hyperparathyroidism-phpt-caused-by-a-single-adenoma
#17
Michael M Krausz, Orwa Younis, Ahmad Mahamid, Miri Bidder, Ricardo Alfici
INTRODUCTION: Minimally Invasive Parathyroidectomy (MIP) has become the treatment of choice of Primary Hyperparathyroidism (PHPT) caused by an adenoma. In the present investigation we describe our experience with MIP performed under local anesthesia. METHODS: MIP was performed on 454 of 496 patients (91.5%) with PHPT. In 170 patients (37.4%), MIP was accomplished under local anesthesia. This procedure was elected when the medical condition prohibited general anesthesia, or in accordance with the patient's request...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28528295/a-machine-learning-graph-based-approach-for-3d-segmentation-of-bruch-s-membrane-opening-from-glaucomatous-sd-oct-volumes
#18
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Milan Sonka, Mona K Garvin
Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points in individual B-scans, in this work, we propose a machine-learning graph-based approach for true 3D segmentation of BMO from glaucomatous SD-OCT volumes...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28511096/improved-amplification-results-following-episodes-of-failure-to-amplify-at-the-amelogenin-locus-using-powerplex-%C3%A2-esi-16-fast-system
#19
Sigal Berlyne, Carla Oz, Naftaly Einot, Shlomit Avraham, Tanya Ram, Miri D Goldberg, Ron Gafny
In 2012 the Israel Police DNA Casework laboratory adopted the 16 STR PowerPlex(®) ESI kit for routine use. The Promega Company updated this kit and developed the PowerPlex(®) ESI 16 Fast System in which all autosomal primer pairs remained identical to the original set, except at the amelogenin site. The master mix was improved and optimized which allowed for direct, faster and more robust amplification. Prior to implementing the PowerPlex(®) ESI 16 Fast System in our lab, we conducted a preliminary assay where 213 casework samples were amplified using the new kit...
April 29, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28509991/camellia-sinensis-increased-apoptosis-on-u2os-osteosarcoma-cells-and-wound-healing-potential-on-nih3t3-fibroblast-cells
#20
Sinem Er, Miriş Dikmen
Camellia sinensis (Cs) is a plant which is rich in polyphenols and has antioxidant, antiinflammatory, antimutagenic, anticarcinogenic and antibacterial activities. In this study, two different methanol extracts (Cs-I and Cs-II) were prepared from the leaf of C. sinensis in order to investigate the wound healing and anticancer activities. Total phenolic content and antioxidant activity of the extracts were determined. Wound healing effects of Cs extracts were evaluated by using Masson's Trichrome Tecnique on NIH3T3 fibroblast cells...
May 16, 2017: Cytotechnology
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