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https://www.readbyqxmd.com/read/29228428/inhibition-of-mmps-cat-g-and-downregulates-the-signaling-of-tgf-%C3%AE-smad-in-chronic-photodamaged-human-fibroblasts
#1
Y Zheng, Q-F Xu, H-Y Chen, C-X Ye, W Lai, H I Maibach
OBJECTIVE: To understand the action of Cathepsin G (Cat G) and matrix metalloproteases (MMPs) on the β/Smad pathway of transforming growth factor β (TGF-β) in chronically photodamaged human fibroblasts. Cat G plays a significant role in the process of skin photoaging and in collagen synthesis and degradation which is induced by UV irradiation it could interact with TGF-β/Smad signaling. No available studies have thoroughly explored its molecular mechanisms of photoaging regulation...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29227927/new-insight-into-the-enhanced-visible-light-driven-photocatalytic-activity-of-pd-pdcl2-doped-bi2wo6-photocatalysts
#2
Xiangchao Meng, Hanna Qin, Zisheng Zhang
A bismuth-based compound, Bi2WO6, was successfully synthesized using a facile hydrothermal method. Aiming to improve its photocatalytic activity under visible light irradiation, Pd/PdCl2 was first doped onto the surface of Bi2WO6 via a photo-reduction method. The prepared Pd/PdCl2-Bi2WO6 samples were characterized based on crystal structures, chemical states, atomic compositions, and morphologies as well as photoabsorption properties. In the screening tests for photocatalytic activity, the 4% Pd-Bi2WO6 sample performed with the highest removal efficiency with respect to the degradation of phenol in wastewater...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29227926/enhanced-photocatalytic-h2-production-activity-of-c-dots-modified-g-c3n4-tio2-nanosheets-composites
#3
Yang Li, Xionghan Feng, Zhexue Lu, Hui Yin, Fan Liu, Quanjun Xiang
As a new carbon-based material, carbon dots (C-dots) have got widely preference because of its excellent electronic transfer capability. In this work, a novel ternary layered C-dots/g-C3N4/TiO2 nanosheets (CGT) composite photocatalysts were prepared by impregnation precipitation methods. The optimal ternary CGT composite samples revealed high photocatalytic hydrogen evolution rate in triethanolamine aqueous solutions, which exceeded the rate of the optimal g-C3N4/TiO2 composite sample by a factor of 5 times...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29227843/symbolic-perceptions-of-methamphetamine-differentiating-between-ice-and-shake
#4
Heith Copes, Whitney Tchoula, Jennifer Kim, Jared Ragland
BACKGROUND: Although public perceptions of methamphetamine (meth) consider all forms of the drug as the same, this is not true among those who use it. Our aim is to examine how those who use meth perceive two forms of meth (ice and shake) using the theoretical framework of symbolic boundaries. METHODS: We rely on data collected from a photo-ethnography with people who use methamphetamine in rural Alabama. The ethnography consisted of formal interviews (with 52 participants), informal observations, and photography...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29227822/automated-retinal-health-diagnosis-using-pyramid-histogram-of-visual-words-and-fisher-vector-techniques
#5
Joel E W Koh, Eddie Y K Ng, Sulatha V Bhandary, Yuki Hagiwara, Augustinus Laude, U Rajendra Acharya
Untreated age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma may lead to irreversible vision loss. Hence, it is essential to have regular eye screening to detect these eye diseases at an early stage and to offer treatment where appropriate. One of the simplest, non-invasive and cost-effective techniques to screen the eyes is by using fundus photo imaging. But, the manual evaluation of fundus images is tedious and challenging. Further, the diagnosis made by ophthalmologists may be subjective...
December 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29227689/emergent-electronic-and-dielectric-properties-of-interacting-nanoparticles-at-finite-temperature
#6
Arin R Greenwood, Márton Vörös, Federico Giberti, Giulia Galli
Lead chalcogenide nanoparticle solids have been successfully integrated into certified solar cells, and represent promising platforms for the design of novel photo-absorbers for photo-electrochemical cells. While much attention has been drawn to improving efficiency and device performance through altering the character of the individual nanoparticles, the role of interactions between nanoparticles is not yet well understood. Using first principles molecular dynamics and electronic structure calculations, we investigated the combined effect of temperature and interaction on functionalized lead chalcogenide nanoparticles (NPs)...
December 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/29226708/-men-are-in-front-at-eating-time-but-not-when-it-comes-to-rearing-the-chicken-unpacking-the-gendered-benefits-and-costs-of-livestock-ownership-in-kenya
#7
Sarah E Dumas, Abena Maranga, Patrick Mbullo, Shalean Collins, Pauline Wekesa, Maricianah Onono, Sera L Young
BACKGROUND: Livestock can promote resilience in low-income communities through a number of pathways. Livestock development programs seek to amplify these benefits but often fail to consider the costs to intended beneficiaries or the effect of prevailing gender norms. OBJECTIVE: To explore perceptions of livestock ownership among female smallholder livestock keepers in Nyanza Region, Kenya, and unpack how the distribution of livestock benefits and investments varies by gender within households...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29226670/carrier-trapping-by-oxygen-impurities-in-molybdenum-diselenide
#8
Ke Chen, Anupam Roy, Amritesh Rai, Amithraj Valsaraj, Xianghai Meng, Feng He, Xiaochuan Xu, Leonard Frank Register, Sanjay K Banerjee, Yaguo Wang
Understanding defect effect on carrier dynamics is essential for both fundamental physics and potential applications of transition metal dichalcogenides. Here, the phenomenon of oxygen impurities trapping photo-excited carriers has been studied with ultrafast pump-probe spectroscopy. Oxygen impurities are intentionally created in exfoliated multilayer MoSe2 with Ar+ plasma irradiation and air exposure. After plasma treatment, the signal of transient absorption first increases and then decreases, which is a signature of defect capturing carriers...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29226665/light-enhanced-carbon-dioxide-activation-and-conversion-by-effective-plasmonic-coupling-effect-of-pt-and-au-nanoparticles
#9
Hui Song, Xianguang Meng, Thang Duy Dao, Wei Zhou, Huimin Liu, Li Shi, Huabin Zhang, Tadaaki Nagao, Tetsuya Kako, Jinhua Ye
Photocatalytic reduction of carbon dioxide (CO2) is attractive for the production of valuable fuels and mitigating the influence of greenhouse gas emission. However, the extreme inertness of CO2 and the sluggish kinetics of photo-excited charge carrires transfer process greatly limit the conversion efficiency of CO2 photoreduction. Herein, we report that the plasmonic coupling effect of Pt and Au nanoparticles (NPs) profoundly enhance the efficiency of CO2 reduction through dry reforming of methane reaction assisted by light illumination, reducing activation energies for CO2 reduction ~30% below thermal activation energies and achieving a reaction rate 2...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29226470/photo-crosslinkable-unnatural-amino-acids-enable-facile-synthesis-of-thermoresponsive-nano-to-microgels-of-intrinsically-disordered-polypeptides
#10
Simone A Costa, Joseph R Simon, Miriam Amiram, Lei Tang, Stefan Zauscher, Eric M Brustad, Farren J Isaacs, Ashutosh Chilkoti
Hydrogel particles are versatile materials that provide exquisite, tunable control over the sequestration and delivery of materials in pharmaceutics, tissue engineering, and photonics. The favorable properties of hydrogel particles depend largely on their size, and particles ranging from nanometers to micrometers are used in different applications. Previous studies have only successfully fabricated these particles in one specific size regime and required a variety of materials and fabrication methods. A simple yet powerful system is developed to easily tune the size of polypeptide-based, thermoresponsive hydrogel particles, from the nano- to microscale, using a single starting material...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29226433/interlocked-photo-degradable-macrocycles-allow-one-off-photo-triggerable-gelation-of-organo-and-hydrogelators
#11
Sheng-Hsien Chiu, Shun-Te Tung, Hung-Te Cheng, Alex Inthasot, Fang-Che Hsueh, Pei-Cong Yan, Ting-Jia Gu, Chien-Chen Lai
[2]Rotaxanes displaying one-off photo-triggerable gelation properties have been synthesized through the "clipping" of photo-degradable macrocycles around the amide or urea functionalities of organo- and hydrogelators. Irradiation with UV light cleaved the photo-labile macrocyclic components from the [2]rotaxanes, resulting in the free gelators being released into solution and, thereafter, forming gels. When the rate of gelation was sufficiently rapid, selective gelation of specific regions of the solution-and, indeed, photo-patterning of the solution-was possible...
December 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29226063/advances-in-antimicrobial-photodynamic-inactivation-at-the-nanoscale
#12
Nasim Kashef, Ying-Ying Huang, Michael R Hamblin
The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light...
August 2017: Nanophotonics
https://www.readbyqxmd.com/read/29226058/towards-fingermark-dating-a-raman-spectroscopy-proof-of-concept-study
#13
Per Ola Andersson, Christian Lejon, Therese Mikaelsson, Lars Landström
Fingermarks have, for a long time, been vital in the forensic community for the identification of individuals, and a possibility to non-destructively date the fingermarks would of course be beneficial. Raman spectroscopy is, herein, evaluated for the purpose of estimating the age of fingermarks deposits. Well-resolved spectra were non-destructively acquired to reveal spectral uniqueness, resembling those of epidermis, and several molecular markers were identified that showed different decay kinetics: carotenoids > squalene > unsaturated fatty acids > proteins...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226025/permeable-protein-loaded-polymersome-cascade-nanoreactors-by-polymerization-induced-self-assembly
#14
Lewis D Blackman, Spyridon Varlas, Maria C Arno, Alice Fayter, Matthew I Gibson, Rachel K O'Reilly
Enzyme loading of polymersomes requires permeability to enable them to interact with the external environment, typically requiring addition of complex functionality to enable porosity. Herein, we describe a synthetic route towards intrinsically permeable polymersomes loaded with functional proteins using initiator-free visible light-mediated polymerization-induced self-assembly (photo-PISA) under mild, aqueous conditions using a commercial monomer. Compartmentalization and retention of protein functionality was demonstrated using green fluorescent protein as a macro-molecular chromophore...
October 31, 2017: ACS Macro Letters
https://www.readbyqxmd.com/read/29225706/comparison-of-photo-and-thermally-initiated-polymerization-induced-self-assembly-a-lack-of-end-group-fidelity-drives-the-formation-of-higher-order-morphologies
#15
Lewis D Blackman, Kay E B Doncom, Matthew I Gibson, Rachel K O'Reilly
Polymerization-induced self-assembly (PISA) is an emerging industrially relevant technology, which allows the preparation of defined and predictable polymer self-assemblies with a wide range of morphologies. In recent years, interest has turned to photoinitiated PISA processes, which show markedly accelerated reaction kinetics and milder conditions, thereby making it an attractive alternative to thermally initiated PISA. Herein, we attempt to elucidate the differences between these two initiation methods using isothermally derived phase diagrams of a well-documented poly(ethylene glycol)-b-(2-hydroxypropyl methacrylate) (PEG-b-HPMA) PISA system...
May 14, 2017: Polymer Chemistry
https://www.readbyqxmd.com/read/29225678/pregnancy-in-women-with-klippel-trenaunay-syndrome-report-of-three-pregnancies-in-a-single-patient-and-review-of-literature
#16
Anish Keepanasseril, K Keerthana, Arun Keepanasseril, Dilip K Maurya, D Kadambari, Sharath Sistla
Klippel-Trenaunay syndrome is characterised by vascular abnormality which increases the risk of thromboembolism and haemorrhage. Physiological changes in pregnancy pose an increased risk to these complications. Being an uncommon disorder, there is limited literature about the management of women with pregnancy and Klippel-Trenaunay syndrome. We report in detail two of three pregnancies in a woman with Klippel-Trenaunay syndrome who had repeated episodes of haematochezia leading to anaemia, managed with Argon laser Photo-Coagulation in pregnancy and also reviewed the complications and the management of pregnant women with Klippel-Trenaunay syndrome...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29224907/quantitative-postural-analysis-of-children-with-congenital-visual-impairment
#17
Michelle de Pádua, Juliana F Sauer, Silvia M A João
OBJECTIVES: The aim of this study was to compare the postural alignment of children with visual impairment with that of children without visual impairment. METHODS: The sample studied was 74 children of both sexes ages 5 to 12 years. Of these, 34 had visual impairment and 40 were control children. Digital photos from the standing position were used to analyze posture. Postural variables, such as tilt of the head, shoulder position, scapula position, lateral deviation of the spine, ankle position in the frontal plane and head posture, angle of thoracic kyphosis, angle of lumbar lordosis, pelvis position, and knee position in the frontal and sagittal planes, were measured with the Postural Assessment Software 0...
December 7, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29224249/pili-annulati-in-a-case-of-rothmund-thomson-syndrome-with-a-novel-frameshift-mutation-in-recql4
#18
B Bhoyrul, H Lindsay, R Robinson, J Stahlschmidt, T Palmer, S Edward, S M Clark
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis characterised by erythematous patches or plaques and sometimes swelling and blisters, which appear during infancy on photo-exposed sites, usually the cheeks, then progress to poikiloderma. Other features include gastrointestinal disturbance, short stature, sparse scalp hair/eyebrows/eyelashes, skeletal abnormalities, juvenile cataracts, hypogonadism and a susceptibility to malignancy. Two forms have been described: Type I, characterised by poikiloderma, ectodermal dysplasia and juvenile cataracts, negative for the RECQL4 mutation, and Type II, with poikiloderma, congenital bone defects and increased risk of osteosarcoma related to deleterious RECQL4 mutations...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29223573/biocompatibility-of-designed-micno-zno-particles-cytotoxicity-genotoxicity-and-phototoxicity-in-human-skin-keratinocyte-cells
#19
Hatice Genç, Banu Barutca, A Tansu Koparal, Uğurcan Özöğüt, Yücel Şahin, Ender Suvacı
Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (=Micron+naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse effects of nanoparticles. It has been shown that MicNo-ZnO particles exhibit both micron and nanosized particle characteristics. Although physical and chemical properties of MicNo-ZnO particles have been studied, their biocompatibility has not yet been evaluated. Accordingly, the research objective of this study was to evaluate in vitro cytotoxicity, genotoxicity and phototoxicity behaviors of designed MicNo-ZnO particles over human epidermal keratinocyte (HaCaT) cells...
December 6, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29222998/experiences-of-connectivity-and-severance-in-the-wake-of-a-new-motorway-implications-for-health-and-well-being
#20
Amy Nimegeer, Hilary Thomson, Louise Foley, Shona Hilton, Fiona Crawford, David Ogilvie
The construction of new urban roads may cause severance, or the separation of residents from local amenities or social networks. Using qualitative data from a natural experimental study, we examined severance related to a new section of urban motorway constructed through largely deprived residential neighbourhoods in Glasgow, Scotland. Semi-structured and photo-elicitation interviews were used to better understand severance and connectivity related to the new motorway, and specifically implications for individual and community-level health and well-being through active travel and social connections...
November 29, 2017: Social Science & Medicine
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