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hpv oropharyngeal cancer

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https://www.readbyqxmd.com/read/28431302/quality-of-life-in-survivors-of-oropharyngeal-cancer-a%C3%A2-systematic-review-and-meta-analysis-of-1366-patients
#1
REVIEW
Sanne Høxbroe Michaelsen, Christian Grønhøj, Jacob Høxbroe Michaelsen, Jeppe Friborg, Christian von Buchwald
Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is rapidly increasing in incidence and has a favourable prognosis compared with HPV-negative disease. Current combined therapies include significant risks of morbidity for the growing group of survivors. This systematic review and meta-analysis investigates how treatment affects quality of life (QoL) in survivors of oropharyngeal cancer. PubMed, EMBASE and the Cochrane Library were systematically searched for all studies reporting patient-assessed QoL at least 1 year after treatment for OPC...
April 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28423662/comparative-analysis-of-hpv16-gene-expression-profiles-in-cervical-and-in-oropharyngeal-squamous-cell-carcinoma
#2
Andrea Cerasuolo, Clorinda Annunziata, Marianna Tortora, Noemy Starita, Giovanni Stellato, Stefano Greggi, Maria Grazia Maglione, Franco Ionna, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
Human papillomavirus type 16 (HPV16) is the major cause of cervical cancer and of a fraction of oropharyngeal carcinoma. Few studies compared the viral expression profiles in the two types of tumor. We analyzed HPV genotypes and viral load as well as early (E2/E4, E5, E6, E6*I, E6*II, E7) and late (L1 and L2) gene expression of HPV16 in cervical and oropharyngeal cancer biopsies. The study included 28 cervical squamous cell carcinoma (SCC) and ten oropharyngeal SCC, along with pair-matched non-tumor tissues, as well as four oropharynx dysplastic tissues and 112 cervical intraepithelial neoplasia biopsies...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418875/incidence-and-clearance-of-oral-human-papillomavirus-infection-a-population-based-cohort-study-in-rural-china
#3
Chaoting Zhang, Fangfang Liu, Yaqi Pan, Qiuju Deng, Xiang Li, Zhonghu He, Mengfei Liu, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415759/kshv-co-infection-down-regulates-hpv16-e6-and-e7-from-cervical-cancer-cells
#4
Lu Dai, Yueyu Cao, Wei Jiang, Jovanny Zabaleta, Zhongmin Liu, Jing Qiao, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of some malignancies such as cervical, oral and oropharyngeal cancers. Kaposi sarcoma-associated herpesvirus (KSHV) represents a principal causative agent of several human cancers arising in those immunocompromised patients. Interestingly, KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is very low and few reports are about KSHV/HPV co-infection. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasias...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414659/knowledge-of-hpv-related-oropharyngeal-cancer-and-use-of-human-papillomavirus-vaccines-by-pediatricians-in-louisiana
#5
Vikas Mehta, Sean Holmes, Adam Master, Blake Leblanc, L Gloria Caldito, Joseph Bocchini
OBJECTIVES: To determine the level of knowledge of HPV related oropharyngeal cancer and practice patterns of HPV vaccine use by pediatricians. STUDY DESIGN, SUBJECTS, METHODS: IRB approved 18-question survey was administered to members of the Louisiana Chapter of the American Academy of Pediatrics. RESULTS: We received 116 responses (response rate: 15.9 percent );. 104 respondents (89.66 percent ); routinely recommend/offer HPV vaccine, 6 (5...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28397651/-transmission-of-and-infection-with-human-papillomavirus-in-the-oropharynx
#6
Anne Bohr, Christian Grønhøj, Christel Lajer, Jan Gerstoft, Christian von Buchwald
The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer is rising in the Western world, but little is known about transmission of the infection and the premalignant phase of the disease. In this article there is an overview of current knowledge with focus on transmission of HPV and risk factors which may lead to persistent infection and eventually cancer. Furthermore, there is a discussion about issues concerning the ability to measure and detect infection and the premalignant stadium in the oropharyngeal tissue...
March 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28397563/pathologic-markers-in-surgically-treated-hpv-associated-oropharyngeal-cancer-retrospective-study-systematic-review-and-meta-analysis
#7
Patrick Tassone, Meghan Crawley, Cory Bovenzi, Tingting Zhan, William Keane, David Cognetti, Adam Luginbuhl, Joseph Curry
OBJECTIVE: Human papillomavirus-associated (HPV) oropharyngeal cancer is a unique clinical entity whose incidence is increasing. It is controversial whether traditional pathologic markers of aggressive head and neck cancer also apply in surgically treated HPV-associated disease. STUDY DESIGN: Retrospective study, systematic review, and meta-analysis Data Sources: PubMed and Cochrane review. REVIEW METHODS: PubMed and Cochrane review were searched for published articles on surgically treated HPV-associated oropharyngeal cancer...
May 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28397339/recent-trends-in-oropharyngeal-cancer-funding-and-public-interest
#8
Michael A Blasco, Peter F Svider, Troy Tenbrunsel, Gautham Vellaichamy, George H Yoo, Andrew M Fribley, S Naweed Raza
OBJECTIVES/HYPOTHESIS: The incidence of oropharyngeal cancer (OPC) has increased in the United States. This has been driven by an increase in human papillomavirus (HPV)-positive OPC. Our objective is to determine trends in National Institutes (NIH)-supported research funding and public interest in OPC. METHODS: The NIH Research Portfolio Online Reporting Tools database was evaluated for projects related to OPC between 2004 and 2015. Projects were evaluated for total funding, relation to HPV, principal investigator departmental affiliation and degree, and NIH agency or center responsible for grant...
April 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28391376/evolving-disparities-in-the-epidemiology-of-oral-cavity-and-oropharyngeal-cancers
#9
Pardis Javadi, Arun Sharma, Whitney E Zahnd, Wiley D Jenkins
Incidence rates of head and neck cancers (HNC) associated with human papillomavirus (HPVa) infection are increasing while non-HPV-associated (non-HPVa) HNC cancer rates are decreasing. As nearly all sexually active individuals will acquire an HPV infection, it is important to understand epidemiologic trends of HNCs associated with this sexually transmitted disease. We analyzed SEER 9 (1973-2012) and 18 data (2000-2012) for HPVa HNCs (oropharynx area; OP) and non-HPVa (oral cavity area; OC). Incidence rates were examined by gender, race, rurality, geographic location, and time...
April 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28383029/genetic-mutation-and-exosome-signature-of-human-papilloma-virus-associated-oropharyngeal-cancer
#10
Anbarasu Kannan, Kate L Hertweck, Julie V Philley, Robert B Wells, Santanu Dasgupta
Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in this HPVOPC subject and an additional set of 15 HPVOPC cases...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381277/unique-dna-methylation-signature-in-hpv-positive-head-and-neck-squamous-cell-carcinomas
#11
Davide Degli Esposti, Athena Sklias, Sheila C Lima, Stéphanie Beghelli-de la Forest Divonne, Vincent Cahais, Nora Fernandez-Jimenez, Marie-Pierre Cros, Szilvia Ecsedi, Cyrille Cuenin, Liacine Bouaoun, Graham Byrnes, Rosita Accardi, Anne Sudaka, Valérie Giordanengo, Hector Hernandez-Vargas, Luis Felipe Ribeiro Pinto, Ellen Van Obberghen-Schilling, Zdenko Herceg
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited. METHODS: We performed global and stratified pooled analyses of epigenome-wide data in HNSCCs based on the Illumina HumanMethylation450 bead-array data in order to identify tissue-specific components and common viral epigenetic targets in HPV-associated tumours...
April 5, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28378539/a-systematic-investigation-of-the-association-between-hpv-and-the-clinicopathological-parameters-and-prognosis-of-oral-and-oropharyngeal-squamous-cell-carcinomas
#12
Fengze Wang, Hui Zhang, Yang Xue, Jiao Wen, Jun Zhou, Xinjie Yang, Jianhua Wei
Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility...
April 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28376197/kinetics-of-the-human-papillomavirus-type-16-e6-antibody-response-prior-to-oropharyngeal-cancer
#13
Aimée R Kreimer, Mattias Johansson, Elizabeth L Yanik, Hormuzd A Katki, David P Check, Krystle A Lang Kuhs, Martina Willhauck-Fleckenstein, Dana Holzinger, Allan Hildesheim, Ruth Pfeiffer, Craig Williams, Neal D Freedman, Wen-Yi Huang, Mark P Purdue, Angelika Michel, Michael Pawlita, Paul Brennan, Tim Waterboer
Background: In a European cohort, it was previously reported that 35% of oropharyngeal cancer (OPC) patients were human papillomavirus type-16 (HPV16) seropositive up to 10 years before diagnosis vs 0.6% of cancer-free controls. Here, we describe the kinetics of HPV16-E6 antibodies prior to OPC diagnosis. Methods: We used annual serial prediagnostic blood samples from the PLCO Cancer Screening Trial. Antibodies to HPV were initially assessed in prediagnostic blood drawn at study enrollment from 198 incident head and neck cancer patients (median years to cancer diagnosis = 6...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28374634/management-of-recurrent-and-metastatic-hpv-positive-oropharyngeal-squamous-cell-carcinoma-after-transoral-robotic-surgery
#14
John R Sims, Kathryn Van Abel, Eliot J Martin, Christine M Lohse, Daniel L Price, Kerry D Olsen, Eric J Moore
Objective To describe management and oncologic outcomes for patients who develop locoregional recurrence (LRR) or distant metastasis (DM) following transoral robotic surgery for human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods A total of 286 patients with HPV-positive OPSCC who underwent transoral robotic surgery-based treatment from May 2007 to May 2015. Results Of 286 patients (12...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28373450/human-papilloma-virus-positive-oropharyngeal-squamous-cell-carcinoma-in-the-elderly
#15
Eesha Dave, William Su, Vishal Gupta, Brett Miles, Elizabeth Demicco, Theresa Soriano, Richard L Bakst
BACKGROUND/AIM: Elderly patients with HPV+ oropharyngeal cancer (OPC) represent an understudied cohort of the HPV epidemic. We aimed to investigate the clinical presentation, treatment tolerability and outcomes in patient's ≥65 years old with HPV+ OPC. PATIENTS AND METHODS: We identified all patients aged 65 and older treated at our Institution with HPV+ OPC and analyzed patient demographics, disease characteristics, treatment modalities, toxicities, treatment failures, and survival...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28369882/worldwide-burden-of-cancer-attributable-to-hpv-by-site-country-and-hpv-type
#16
Catherine de Martel, Martyn Plummer, Jerome Vignat, Silvia Franceschi
HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancer and oropharyngeal cancer. Understanding the HPV-attributable cancer burden can boost programs of HPV vaccination and HPV-based cervical screening. Attributable fractions (AF) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age-standardized incidence rates of HPV-attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract, and head and neck cancers...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28362190/hpv-epigenetic-mechanisms-related-to-oropharyngeal-and-cervix-cancers
#17
Marina Di Domenico, Giancarlo Giovane, Soumaya Kouidhi, Rosamaria Iorio, Maurizio Romano, Francesco De Francesco, Antonia Feola, Camilla Siciliano, Luigi Califano, Antonio Giordano
Human Papilloma Virus infection is very frequent in humans and is mainly transmitted sexually. The majority of infections are transient and asymptomatic, however, if the infection persists, it can occur with a variety of injuries to skin and mucous membranes, depending on the type of HPV involved. Some types of HPV are classified as high oncogenic risk as associated with the onset of cancer. The tumors most commonly associated with HPV are cervical and oropharyngeal cancer, epigenetic mechanisms related to HPV infection include methylation changes to host and viral DNA and chromatin modification in host species...
March 31, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28357043/recent-advances-in-understanding-and-preventing-human-papillomavirus-related-disease
#18
REVIEW
Karin Hellner, Lucy Dorrell
High-risk human papillomaviruses (hrHPV) are responsible for anogenital and oropharyngeal cancers, which together account for at least 5% of cancers worldwide. Industrialised nations have benefitted from highly effective screening for the prevention of cervical cancer in recent decades, yet this vital intervention remains inaccessible to millions of women in low- and middle-income countries (LMICs), who bear the greatest burden of HPV disease. While there is an urgent need to increase investment in basic health infrastructure and rollout of prophylactic vaccination, there are now unprecedented opportunities to exploit recent scientific and technological advances in screening and treatment of pre-invasive hrHPV lesions and to adapt them for delivery at scale in resource-limited settings...
2017: F1000Research
https://www.readbyqxmd.com/read/28356201/the-risk-of-level-ib-nodal-involvement-in-oropharynx-cancer-guidance-for-submandibular-gland-sparing-irradiation
#19
Nicholas C J Lee, Jacqueline R Kelly, Henry S Park, Wendell G Yarbrough, Barbara A Burtness, Zain A Husain
PURPOSE: Xerostomia remains a common side effect of head and neck irradiation. Conflicting data exist regarding the likelihood of level IB involvement for patients with oropharyngeal squamous cell cancer (OPSCC), and data are limited on this risk in patients with human papillomavirus-positive disease. This study examined surgically treated OPSCC to determine the risk of pathologic level IB nodal involvement and to identify a cohort of patients in whom ipsilateral level IB radiation therapy may be safely omitted...
February 16, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28351584/human-papillomavirus-hpv-16-antibodies-at-diagnosis-of-hpv-related-oropharyngeal-cancer-and-antibody-trajectories-after-treatment
#20
Yuehan Zhang, Tim Waterboer, Robert I Haddad, Brett A Miles, Alicia Wentz, Neil D Gross, Carole Fakhry, Harry Quon, Jochen H Lorch, Christine G Gourin, Daniel Clayburgh, Krzysztof J Misiukiewicz, Jeremy D Richmon, Peter E Andersen, Marshall R Posner, Gypsyamber D'Souza
OBJECTIVES: Despite the fact that HPV-driven oropharyngeal cancer (HPV-OPC) has relatively low recurrence rates, intensive post-therapy monitoring remains the standard of care. Post-treatment biomarkers are needed to risk stratify HPV-OPC patients for more individualized surveillance intensity and which remain at higher recurrence risk. MATERIALS AND METHODS: 115 HPV-OPC patients (ascertained by p16 immunohistochemistry and/or in-situ hybridization) from a multicenter prospective case study (HOTSPOT) had blood collected at diagnosis, and 64 of these also had blood collected at post-treatment follow-up visits for up to two years...
April 2017: Oral Oncology
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