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https://www.readbyqxmd.com/read/28633362/human-papillomavirus-related-oropharyngeal-cancer
#1
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía
High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28632936/peritumoral-cuffing-by-t-cell-tumor-infiltrating-lymphocytes-distinguishes-hpv-related-oropharyngeal-squamous-cell-carcinoma-from-oral-cavity-squamous-cell-carcinoma
#2
Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant
BACKGROUND: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors. METHODS: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative)...
June 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#3
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28619685/molecular-mechanisms-of-human-papillomavirus-related-carcinogenesis-in-head-and-neck-cancer
#4
REVIEW
Farhoud Faraji, Munfarid Zaidi, Carole Fakhry, Daria A Gaykalova
This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.
June 12, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28618252/epidemiological-trends-of-head-and-neck-cancer-in-the-united-states-a%C3%A2-seer-population-study
#5
Moustafa Mourad, Thomas Jetmore, Ameya A Jategaonkar, Sami Moubayed, Erin Moshier, Mark L Urken
PURPOSE: This study represents the most recent epidemiologic trends of head and neck cancer (HNC) in the United States. It provides an important discussion on oropharyngeal cancer and cancers related to the human papillomavirus. The objective was to identify trends in HNC (2002 to 2012) within the United States. MATERIALS AND METHODS: This study is a retrospective analysis of the US National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) submission...
May 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28611308/an-oral-keratinocyte-life-cycle-model-identifies-novel-host-genome-regulation-by-human-papillomavirus-16-relevant-to-hpv-positive-head-and-neck-cancer
#6
Michael R Evans, Claire D James, Oonagh Loughran, Tara J Nulton, Xu Wang, Molly L Bristol, Brad Windle, Iain M Morgan
Many aspects of the HPV life cycle have been characterized in cervical cell lines (W12, CIN612) and in HPV immortalized primary foreskin keratinocytes. There is now an epidemic of HPV positive oropharyngeal cancers (HPV16 is responsible for 80-90% of these); therefore increased understanding of the HPV16 life cycle in oral keratinocytes is a priority. To date there have been limited reports characterizing the HPV16 life cycle in oral keratinocytes. Using TERT immortalized "normal" oral keratinocytes (NOKs) we generated clonal cell lines maintaining the HPV16 genome as an episome, NOKs+HPV16...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608796/the-natural-history-of-oral-human-papillomavirus-in-young-costa-rican-women
#7
Daniel C Beachler, Krystle A Lang Kuhs, Linda Struijk, John Schussler, Rolando Herrero, Carolina Porras, Allan Hildesheim, Bernal Cortes, Joshua Sampson, Wim Quint, Paula Gonzalez, Aimée R Kreimer
BACKGROUND: Oral human papillomavirus (HPV) infection and related oropharyngeal cancer are uncommon in lower-income countries, particularly compared to HPV-associated cervical cancer. However, little is known about the natural history of oral HPV in less-developed settings and how it compares to the natural history of cervical HPV. METHODS: Three hundred fifty women aged 22 to 33 years from the Costa Rica Vaccine Trial provided exfoliated cells from the cervical and oral regions at 2 visits 2 years apart...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28607924/hipk2-overexpression-and-its-prognostic-role-in-human-papillomavirus-positive-tonsillar-squamous-cell-carcinoma
#8
Mi Jung Kwon, So Young Kang, Eun Sook Nam, Seong Jin Cho, Young-Soo Rho
Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is involved in HPV-associated uterine cervical and cutaneous carcinogenesis through its binding of HPV E6, thereby preventing apoptosis and contributing to tumor progression. However, its clinical and prognostic significance in TSCC remains unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28607383/isolation-detection-and-quantification-of-cancer-biomarkers-in-hpv-associated-malignancies
#9
Hakan Inan, Shuqi Wang, Fatih Inci, Murat Baday, Richard Zangar, Sailaja Kesiraju, Karen S Anderson, Brian T Cunningham, Utkan Demirci
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in the development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In the development of cancer, persistent HPV infections induce E6 and E7 oncoproteins, which promote cell proliferation and carcinogenesis resulting elevated levels of host antibodies (e.g., anti-HPV16 E7 antibody). Currently, these cancers are clinically diagnosed using invasive biopsy-based tests, which are performed only in centralized labs by experienced clinical staff using time-consuming and expensive tools and technologies...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604441/increasing-human-papillomavirus-vaccine-coverage-among-men-who-have-sex-with-men-national-hiv-behavioral-surveillance-united-states-2014
#10
Sara E Oliver, Brooke E Hoots, Gabriela Paz-Bailey, Lauri E Markowitz, Elissa Meites
BACKGROUND: Human papillomavirus (HPV) can cause oropharyngeal and anogenital cancers among men who have sex with men (MSM). In 2011, the Advisory Committee on Immunization Practices (ACIP) extended HPV vaccine recommendations to males through age 21 and MSM through age 26. Because of this distinction, vaccination for some MSM might rely on sexual behavior disclosure to health care providers. Receipt of ≥1 HPV vaccination among MSM aged 18-26 in National HIV Behavioral Surveillance (NHBS) was 4...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28601094/prognostic-factors-for-head-and-neck-cancer-of-unknown-primary-including-the-impact-of-human-papilloma-virus-infection
#11
Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid
BACKGROUND: Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. In the last decade, human papilloma virus (HPV) has been identified as a common cause of and important prognostic factor in oropharyngeal cancer, and there is now growing interest in the importance of HPV for HNCUP...
June 10, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28600705/distress-levels-in-patients-with-oropharyngeal-vs-non-oropharyngeal-squamous-cell-carcinomas-of-the-head-and-neck-over-1%C3%A2-year-after-diagnosis-a-retrospective-cohort-study
#12
Melissa Schorr, Linda E Carlson, Harold Y Lau, Lihong Zhong, Barry D Bultz, Amy Waller, Shannon L Groff, Desiree Hao
BACKGROUND: Human papillomavirus (HPV)-related cancers have been associated with different demographic profiles and disease characteristics than HPV-unrelated cancers in head and neck patients, but distress and other symptoms have not been compared. The aim of this study was to assess whether distress levels, fatigue, pain, anxiety, depression, and common psychological and practical problems differ between head and neck cancer patients with HPV-related vs. HPV-unrelated carcinomas (using oropharyngeal carcinoma (OPC) and non-OPC cancers as surrogates for HPV status)...
June 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28599791/characterization-of-hpv18-e6-specific-t-cell-responses-and-establishment-of-hpv18-e6-expressing-tumor-model
#13
Ying Ma, Andrew Yang, Shiwen Peng, Jin Qiu, Emily Farmer, Chien-Fu Hung, T-C Wu
Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, and subsets of anogenital and oropharyngeal cancers. HPV18 is the second most prevalent high-risk HPV type after HPV16. Furthermore, HPV18 is responsible for approximately 12% of cervical squamous cell carcinoma and 37% of cervical adenocarcinoma cases worldwide. In this study, we aimed to characterize the HPV18-E6-specific epitope and establish an HPV18 animal tumor model to evaluate the E6-specific immune response induced by our DNA vaccine...
June 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28596256/nccn-guidelines-insights-head-and-neck-cancers-version-2-2017
#14
David Adelstein, Maura L Gillison, David G Pfister, Sharon Spencer, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, William M Lydiatt, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Sue S Yom, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28589730/variation-in-genital-human-papillomavirus-infection-prevalence-and-vaccination-coverage-among-men-and-women-in-the-usa
#15
Jasmine J Han, Christopher M Tarney, John Song
Human papillomavirus (HPV) is the most common sexually transmitted infection that causes majority of anogenital and oropharyngeal cancers. Prophylactic HPV vaccine is available for the primary prevention of cancer and HPV transmission. Here, we are going to discuss the variation of HPV prevalence, HPV vaccination coverage and potential risk factors of men and women, retrieved from the cross-sectional study of the National Health Nutrition Examination Survey, a representative sample of noninstitutionalized, civilian residents in the USA...
June 7, 2017: Future Oncology
https://www.readbyqxmd.com/read/28576176/controversies-in-postoperative-irradiation-of-oropharyngeal-cancer-after-transoral-surgery
#16
REVIEW
Sue S Yom, Jon Mallen-St Clair, Patrick K Ha
Transoral surgery (TOS) is a novel technology whose adoption is expanding in the United States and other countries. TOS offers the possibility of a minimally invasive surgical approach to head and neck cancers. Its most frequent application has been in oropharyngeal cancers (OPC), of which most are associated with human papillomavirus (HPV). For HPV-associated OPC, where high response and survival rates are expected, deintensification of standard therapy is a major area of clinical research. In HPV-OPC, traditional pathologic risk factors indicating a need for adjuvant radiation or chemoradiation may not apply as strongly...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28574836/hpv-associated-differential-regulation-of-tumor-metabolism-in-oropharyngeal-head-and-neck-cancer
#17
Young-Suk Jung, Abdo J Najy, Wei Huang, Seema Sethi, Michael Snyder, Wael Sakr, Gregory Dyson, Maik Hüttemann, Icksoo Lee, Rouba Ali-Fehmi, Silvia Franceschi, Linda Struijk, Harold E Kim, Ikuko Kato, Hyeong-Reh Choi Kim
HPV-positive oropharyngeal cancer patients experience significantly lower locoregional recurrence and higher overall survival in comparison with HPV-negative patients, especially among those who received radiation therapy. The goal of the present study is to investigate the molecular mechanisms underlying the differential radiation sensitivity between HPV-negative and HPV-positive head and neck squamous cell carcinoma (HNSCC). Here, we show that HPV-negative HNSCC cells exhibit increased glucose metabolism as evidenced by increased production of lactate, while HPV-positive HNSCC cells effectively utilize mitochondrial respiration as evidenced by increased oxygen consumption...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28570919/calcein-represses-human-papillomavirus-16-e1-e2-mediated-dna-replication-via-blocking-their-binding-to-the-viral-origin-of-replication
#18
Dipon Das, Nathan W Smith, Xu Wang, Stacie L Richardson, Matthew C T Hartman, Iain M Morgan
Human papillomaviruses are causative agents in several human diseases ranging from genital warts to ano-genital and oropharyngeal cancers. Currently only symptoms of HPV induced disease are treated; there are no antivirals available that directly target the viral life cycle. Previously, we determined that the cellular protein TopBP1 interacts with the HPV16 replication/transcription factor E2. This E2-TopBP1 interaction is essential for optimal E1-E2 DNA replication and for the viral life cycle. The drug calcein disrupts the interaction of TopBP1 with itself and other host proteins to promote cell death...
May 29, 2017: Virology
https://www.readbyqxmd.com/read/28560813/impact-of-positive-margins-on-outcomes-of-oropharyngeal-squamous-cell-carcinoma-according-to-p16-status
#19
Peter Molony, Natallia Kharytaniuk, Seamus Boyle, Robbie S R Woods, Gerard O'Leary, Reiltin Werner, Cynthia Heffron, Linda Feeley, Patrick Sheahan
BACKGROUND: Currently, positive surgical margins in head and neck cancer are considered to be an indicator for postoperative chemoradiotherapy (CRT) over radiotherapy (RT) alone. However, there are less data regarding the impact of margin status on human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC). METHODS: We performed a retrospective review of 55 patients with oropharyngeal SCC undergoing primary surgical treatment. The impact of margin status on disease-specific survival (DSS) was studied according to p16 status...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28559025/oncological-outcome-following-de-intensification-of-treatment-for-stage-i-and-ii-hpv-negative-oropharyngeal-cancers-with-transoral-robotic-surgery-tors-a-prospective-trial
#20
Surender Dabas, Karan Gupta, Reetesh Ranjan, Ashwani K Sharma, Himanshu Shukla, Anant Dinesh
OBJECTIVE: This prospective study aimed to see long-term oncological outcome of Transoral Robotic Surgery as single modality treatment for cT1-T2 N0 HPV negative oropharyngeal malignancies. METHOD: From March 2013 to October 2015, 57 patients with early stage oropharyngeal carcinoma underwent Transoral robotic surgery (TORS) with neck dissection using daVinci® Surgical system. Patients were evaluated for disease free survival, overall survival, locoregional and distant metastasis...
June 2017: Oral Oncology
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