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hpv oropharyngeal cancer

Whitney E Zahnd, Amanda J Fogleman, Wiley D Jenkins
INTRODUCTION: Despite having lower overall incidence rates, rural populations tend to have higher cancer mortality rates. Rural populations often have higher rates of cancers with primary and secondary prevention modalities. However, there is limited research on rural-urban differences in incidence by stage. Therefore, the objective was to assess rural-urban differences in cancer rates by stage. METHODS: The North American Association of Central Cancer Registries public use data set (2009-2013) was used to calculate age-adjusted incidence rates and rate ratios (rural versus urban) for all stageable cancers, tobacco-associated cancers, human papillomavirus-associated cancers, and individual cancers with screening modalities...
March 14, 2018: American Journal of Preventive Medicine
A Beltz, D Gösswein, S Zimmer, R H Stauber, J Hagemann, S Strieth, C Matthias, J Künzel
BACKGROUND: The TNM (tumor, nodes, metastasis) classification is updated periodically according to the literature and international recommendations. With the 8th edition, notable changes have been developed especially with regard to oropharyngeal cancer. MATERIALS AND METHODS: The modifications as well as the practicability of the classification for staging of oropharyngeal cancers are demonstrated on the basis of cases from the tumor database. RESULTS: The latest edition of the TNM classification realizes requirements to differentiate between human papilloma virus (HPV) positive and HPV-negative tumors during staging...
March 13, 2018: HNO
Haitham Mirghani, Ludovic Lacroix, Caroline Rossoni, Roger Sun, Anne Aupérin, Odile Casiraghi, Aude Villepelet, Roger Lacave, Gladwys Faucher, Virginie Marty, Charles Ferté, Jean Charles Soria, Caroline Even
BACKGROUND: Human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) patients are characterised by a better prognosis than their HPV-negative counterparts. However, this significant survival advantage is not homogeneous and among HPV-positive patients those with a smoking history have a significantly increased risk of oncologic failure. The reason why tobacco consumption impacts negatively the prognosis is still elusive. Tobacco might induce additional genetic alterations leading to a more aggressive phenotype...
March 10, 2018: European Journal of Cancer
C Grønhøj, D Jensen, C Dehlendorff, C Nørregaard, E Andersen, L Specht, B Charabi, C von Buchwald
AIMS: The distinct difference in disease phenotype of human papillomavirus-positive (HPV+) and -negative (HPV-) oropharyngeal squamous cell cancer (OPSCC) patients might also be apparent when assessing the effect of time to treatment initiation (TTI). We assessed the overall survival and progression-free survival (PFS) effect from increasing TTI for HPV+ and HPV- OPSCC patients. MATERIALS AND METHODS: We examined patients who received curative-intended therapy for OPSCC in eastern Denmark between 2000 and 2014...
March 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Nolan Kline, Cheryl Vamos, Erika Thompson, Frank Catalanotto, John Petrila, Rita Debate, Stacey Griner, Coralia Vázquez-Otero, Laura Merrell, Ellen Daley
The rise in HPV-related oropharyngeal cancer incidence necessitates novel prevention efforts including multiple provider types. Although dental providers screen for HPV-related oropharyngeal cancers, little is known about their needs to advance "primordial prevention," or interventions at the earliest possible stage, to prevent HPV-related cancers. This study assessed dentists and dental hygienists' perceived roles and needs regarding HPV-related primordial prevention. We conducted a mixed-method study with data from focus groups with dentists (n=33) and dental hygienists (n=48) and surveys from both provider types (n=203) among providers from a diverse set of practice settings and geographic communities...
March 7, 2018: Papillomavirus Research
Emilie A C Dronkers, Senada Koljenovic, Gerda M Verduijn, Robert J Baatenburg de Jong, Jose A U Hardillo
OBJECTIVES/HYPOTHESIS: This study aimed to analyze the effect of human papillomavirus (HPV)-associated T1-2 node-positive oropharyngeal squamous cell carcinoma (OPSCC) on nodal response, recurrent disease, and survival in patients treated according to the Rotterdam protocol. STUDY DESIGN: Retrospective cohort study. METHODS: In total, 77 patients with T1-2 OPSCC with nodal disease, treated between 2000 and 2012, were included in this study...
March 9, 2018: Laryngoscope
Ana P Ortiz, Daisy González, Jeslie Ramos, Cristina Muñoz, Juan Carlos Reyes, Cynthia M Pérez
BACKGROUND: Despite limited data, research suggests that marijuana use is associated with oral HPV infection and periodontitis, two potential oropharyngeal cancer risk factors. We assessed these associations in a Hispanic adult population in Puerto Rico. METHODS: A cross-sectional study of 735 adults assessed marijuana use, determined through an audio computer-assisted self-interview, and periodontitis and self-collection of oral HPV samples following the National Health and Nutrition Examination Survey methodology...
February 22, 2018: Journal of Periodontology
Sasidharanpillai Sabeena, Parvati V Bhat, Veena Kamath, Govindakarnavar Arunkumar
Human papillomavirus (HPV) infections continue to be one of the most common sexually transmitted infections worldwide. The oncogenic potential of this virus was well established in anogenital malignancies and oropharyngeal cancers. Even though a fall in cervical cancer rates has been reported worldwide, the subsequent rise in HPV-associated head and neck cancers among men and women have been reported from developed countries, necessitating the vaccination of adolescent boys as well. The objective of this narrative review is to provide an update on the current status of HPV vaccination worldwide...
March 8, 2018: Journal of Obstetrics and Gynaecology Research
Jennifer Yin Yee Kwan, Jie Su, Shao Hui Huang, Laleh S Ghoraie, Wei Xu, Biu Chan, Kenneth W Yip, Meredith Giuliani, Andrew Bayley, John Kim, Andrew J Hope, Jolie Ringash, John Cho, Andrea McNiven, Aaron Hansen, David Goldstein, John R de Almeida, Hugo J Aerts, John N Waldron, Benjamin Haibe-Kains, Brian O'Sullivan, Scott V Bratman, Fei-Fei Liu
PURPOSE: Distant metastasis (DM) is the main cause of death for patients with human papillomavirus (HPV)-related oropharyngeal cancers (OPCs); yet, there are few reliable predictors of DM in this disease. The role of quantitative imaging (ie, radiomic) analysis was examined to determine whether there are primary tumor features discernible on imaging studies that are associated with a higher risk of DM developing. METHODS AND MATERIALS: Radiation therapy planning computed tomography scans were retrieved for all nonmetastatic p16-positive OPC patients treated with radiation therapy or chemoradiation therapy at a single institution between 2005 and 2010...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Aimée R Kreimer, Meredith S Shiels, Carole Fakhry, Mattias Johansson, Michael Pawlita, Paul Brennan, Allan Hildesheim, Tim Waterboer
No abstract text is available yet for this article.
March 2, 2018: Cancer
Erin E Cook, Susan T Gershman, Jane J Kim, Rulla M Tamimi, R Monina Klevens, Michelle D Holmes
PURPOSE: To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts. METHODS: From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U...
March 1, 2018: Cancer Causes & Control: CCC
Richard B S Roden, Peter L Stern
The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV) initiated a quarter century of laboratory and epidemiological studies that demonstrated their necessary, but not sufficient, aetiological role in cervical and several other anogenital and oropharyngeal cancers. Early virus-induced immune deviation can lead to persistent subclinical infection that brings the risk of progression to cancer. Effective secondary prevention of cervical cancer through cytological and/or HPV screening depends on regular and widespread use in the general population, but coverage is inadequate in low-resource settings...
March 2, 2018: Nature Reviews. Cancer
C René Leemans, Peter J F Snijders, Ruud H Brakenhoff
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk factors are smoking and excessive alcohol consumption, and in recent years, the role of human papillomavirus (HPV) has emerged, particularly in oropharyngeal tumours. HPV-induced oropharyngeal tumours are considered a separate disease entity, which recently has manifested in an adapted prognostic staging system while the results of de-intensified treatment trials are awaited...
March 2, 2018: Nature Reviews. Cancer
Zeno A R Gouw, Jan Paul de Boer, Arash Navran, Michiel W M van den Brekel, Jan-Jakob Sonke, Abrahim Al-Mamgani
OBJECTIVES: To study the prognostic value of abnormalities in baseline complete blood count in patients with oropharyngeal cancer (OPC) treated with (chemo) radiation. METHODS AND MATERIALS: The prognostic value of baseline complete blood count on outcome in 234 patients with OPC treated between 2010 and 2015 was examined in multivariate analysis together with other conventional prognostic variables including HPV-status, tumor stage, tumor and nodal size. RESULTS: The 3-year overall survival (OS), disease-free survival (DFS), locoregional control (LRC), and distant control (DC) of the whole group were 74%, 64%, 79%, and 88%, respectively...
March 2018: Oral Oncology
Farhoud Faraji, Stephanie F Coquia, Meghan B Wenderoth, Ericka S Padilla, Dana Blitz, M Robert DeJong, Nafi Aygun, Ulrike M Hamper, Carole Fakhry
OBJECTIVE: To compare transcervical ultrasonography (US) to standard cross-sectional imaging for the visualization of human papillomavirus-related oropharyngeal cancer (HPV-OPC). MATERIALS AND METHODS: Patients with HPV-OPC and available standard imaging (CT and/or MRI) were identified in clinic and prospectively enrolled. US was performed to visualize the oropharynx and lymph nodes. Tumor characteristics across imaging modalities were evaluated (CT versus MRI, and US versus standard imaging (SI))...
March 2018: Oral Oncology
Marisa Mena, Miren Taberna, Sara Tous, Sandra Marquez, Omar Clavero, Beatriz Quiros, Belen Lloveras, Maria Alejo, Xavier Leon, Miquel Quer, Silvia Bagué, Ricard Mesia, Julio Nogués, Montserrat Gomà, Anton Aguila, Teresa Bonfill, Carmen Blazquez, Marta Guix, Rafael Hijano, Montserrat Torres, Dana Holzinger, Michael Pawlita, Miguel Angel Pavon, Ignacio G Bravo, Silvia de Sanjosé, Francesc Xavier Bosch, Laia Alemany
BACKGROUND: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. METHODS: We conducted a retrospective cohort study of all patients diagnosed with a primary OPC in four Catalonian hospitals from 1990 to 2013. Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a /pRb/p53/Cyclin-D1 immunohistochemistry...
March 2018: Oral Oncology
Kyle Wang, Terence Z Wong, Robert J Amdur, William M Mendenhall, Nathan C Sheets, Rebecca Green, Brian D Thorp, Samip N Patel, Trevor G Hackman, Adam M Zanation, Mark C Weissler, Bhishamjit S Chera
OBJECTIVES: We evaluated patterns of nodal response and positive predictive value (PPV) of 3 month post-treatment PET in patients with HPV-associated oropharyngeal cancer treated on a multi-institutional de-intensification trial. MATERIALS AND METHODS: Eligibility criteria included: (1) T0-3, N0-2c, M0, (2) HPV+/p16+ oropharyngeal squamous cell carcinoma, and (3) ≤10 pack-years smoking or ≤30 pack-years and abstinent ≥5 years. Patients received 60 Gy radiation alone (T0-2, N0-1) or with concurrent weekly cisplatin 30 mg/m2 and surveillance PET three months post-radiation...
March 2018: Oral Oncology
Karolin Schneider, Etienne Marbaix, Caroline Bouzin, Marc Hamoir, Pierre Mahy, Vanesa Bol, Vincent Grégoire
BACKGROUND: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. In this study, we investigated immune cell infiltration in human SCC of the head and neck region and its relation to overall survival after treatment with surgery (with or without radiotherapy) or concomitant chemo (or cetuximab)-radiotherapy...
March 1, 2018: Acta Oncologica
William Su, Brett A Miles, Marshall Posner, Peter Som, Lale Kostakoglu, Vishal Gupta, Richard L Bakst
BACKGROUND/AIM: Current guidelines derived from a pre-human papilloma virus (HPV) era in oropharyngeal cancer do not recommend routine surveillance imaging. We aimed to analyze the method of recurrence detection in HPV+ disease to determine a role for follow-up imaging. PATIENTS AND METHODS: All HPV+ and HPV- oropharyngeal cancer patients treated at our institution from 2005-2016 with biopsy-proven recurrence were identified and their method of recurrence detection was analyzed...
March 2018: Anticancer Research
Kaan Z Apaydin, Holly B Fontenot, Derri L Shtasel, Kenneth H Mayer, Alex S Keuroghlian
Human papillomavirus (HPV) vaccination and anal cancer screening are valuable, yet underutilized, tools in prevention of HPV-related cancers among sexual and gender minority (SGM) populations. The aim of this study was to characterize primary care providers' (PCPs) practices and perceptions pertaining to HPV vaccination and anal cancer screening. A survey assessing self-reported practice characteristics related to HPV vaccination and anal cancer screening, as well as perceived barriers to vaccination and anal cancer screening at the patient-, provider-, and system-level was distributed to PCPs at a Federally-Qualified Health Center that specializes in care for SGM populations in the greater Boston area...
February 26, 2018: Journal of Community Health
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