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https://www.readbyqxmd.com/read/29777209/tuberculous-meningitis-a-roadmap-for-advancing-basic-and-translational-research
#1
Sanjay K Jain, David M Tobin, Elizabeth W Tucker, Vishwanath Venketaraman, Alvaro A Ordonez, Lakshmi Jayashankar, Omar K Siddiqi, Dima A Hammoud, Nemani V Prasadarao, Matyas Sandor, Richard Hafner, Zsuzsanna Fabry
No abstract text is available yet for this article.
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29773279/-non-tuberculous-mycobacterial-cervical-adenitis-in-children-2-cases
#2
N Sigg, S Bailleul, J-M Turmel, G Legrand, S Kettani, L Martin
BACKGROUND: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. PATIENTS AND METHODS: We report two cases of NTM adenitis: one in a 2-year-old girl vaccinated with BCG and one in an unvaccinated 22-month-old boy, in whom a misleading presentation led to delayed diagnosis...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#3
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29768381/tuberculous-pleurisy-mimicking-mycoplasma-pneumoniae-infection-in-a-previously-healthy-young-adult-a-case-report
#4
Daizo Yaguchi, Motoshi Ichikawa, Masato Shizu, Noriko Inoue, Daisuke Kobayashi, Naoyuki Imai, Masao Ito
RATONALE: Sometimes, pleural effusion accompanying an acute Mycoplasma pneumoniae infection or tuberculous pleurisy has similar analysis results. We report a case of tuberculous pleurisy which was initially diagnosed as acute M pneumoniae infection, which is of special interest because anti-Mycoplasma antibody results were positive, which served as a red herring. PATIENT CONCERNS: A 20-year-old woman visited the outpatient emergency romm of our hospital for chief complaints of high fever, dry cough, and pleuralgia persiting for 2 days...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768154/tuberculous-pericarditis
#5
Daniel Faria, Antonio Freitas
New England Journal of Medicine, Volume 378, Issue 20, May 2018.
May 17, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29766338/an-unusual-surgical-indication-for-cerebral-tuberculosis-status-dystonicus-case-report
#6
Andrea Franzini, Angelo Franzini, Vincenzo Levi, Roberto Cordella, Giuseppe Messina
Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. Tuberculosis-related movement disorders are usually treated pharmacologically. We report on a child affected by post-tubercular generalized dystonia, who progressed to status dystonicus (SD) and underwent stereotactic bilateral pallidotomy. After surgery, SD resolved, and drugs were rapidly tapered...
May 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29764749/prognosis-of-chronic-pulmonary-aspergillosis-in-patients-with-pulmonary-non-tuberculous-mycobacterial-disease
#7
Maiko Naito, Yu Kurahara, Shiomi Yoshida, Naoya Ikegami, Takehiko Kobayashi, Shojiro Minomo, Kazunobu Tachibana, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Pulmonary non-tuberculous mycobacterial disease (PNTM) is a known risk factor for chronic pulmonary aspergillosis (CPA). However, few studies have focused on the prognosis of PNTM-associated CPA. In the present investigation, we aimed to elucidate the clinical course and prognostic factors of CPA in patients with PNTM. METHODS: We retrospectively investigated the medical records of 62 patients with CPA and a history of PNTM who were admitted to Kinki-chuo Chest Medical Center between 2010 and 2015...
May 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29760399/publisher-correction-non-tuberculous-mycobacteria-isolated-from-pulmonary-samples-in-sub-saharan-africa-a-systematic-review-and-meta-analyses
#8
Catherine Okoi, Suzanne T B Anderson, Martin Antonio, Sarah N Mulwa, Florian Gehre, Ifedayo M O Adetifa
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760127/-in-vitro-activity-of-clofazimine-against-non-tuberculous-mycobacteriaisolated-in-beijing-china
#9
Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang
Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758242/diagnostic-accuracy-of-nucleic-acid-amplification-based-assays-for-tuberculous-meningitis-a-meta-analysis
#10
Renu Gupta, Puneet Talwar, Pumanshi Talwar, Sarbjeet Khurana, Suman Kushwaha, Nupur Jalan, Rajeev Thakur
BACKGROUND: Numerous in-house and commercial nucleic acid amplification tests (NAAT) have been evaluated using variable reference standards for diagnosis of TBM but their diagnostic potential is still not very clear. METHODS: We conducted a meta-analysis to assess the diagnostic accuracy of different NAAT based assays for diagnosing TBM against 43 data sets of confirmed TBM (n=1066) and 61 data sets of suspected TBM (n=3721) as two reference standards. The summary estimate of the sensitivity and the specificity were obtained using the bivariate model...
May 11, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29756504/tuberculous-peritonitis-and-pleurisy-accompanied-by-pulmonary-cryptococcosis-a-case-report
#11
Jian-Kun Chen, Shu-Bin Cai, Qian Cai, Hang Qi, Ji-Qiang Li
Although the infectious diseases tuberculosis (TB) and cryptococcosis both cause formation of single or multiple nodules in immunodeficient hosts, cases of co-infection of these diseases are rarely seen. We report a patient who was co-infected with TB and cryptococcosis. A male patient with no clinical evidence of immunodeficiency presented with a 3-week history of abdominal distension accompanied by oedema of recurring lower extremities. The patient was diagnosed with tuberculous peritonitis and tuberculous pleurisy by an abdominal puncture biopsy...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29755898/an-unusual-presentation-of-kikuchi-fujimoto-disease-with-recurrent-subdural-effusion
#12
Sara Shahid, Syed H Alam, Indira Hadley
A 24-year-old man complained of a right temporal headache for four weeks. The patient denied any trauma or previous anticoagulation use. He also reported tender right facial swelling. His physical exam was unrevealing except for right cranial nerve (CN) VI palsy, right parotid enlargement, and cervical adenopathy. Laboratory findings were significant for mild leukopenia at 3300 cells/uL. The computed tomography (CT) scan obtained showed a chronic left subdural effusion with a 4 mm midline shift and confirmed right parotid enlargement and cervical lymphadenopathy...
March 10, 2018: Curēus
https://www.readbyqxmd.com/read/29755068/-tuberculous-pleurisy-diagnosed-by-thoracoscopic-lung-biopsy
#13
Jun Yamamoto, Miho Nishiura, Takanori Ohata, Ho Namkoong, Shinji Sakaguchi, Fumitake Saito, Hideki Yuki
A 44-year-old woman was referred to our hospital with pleural effusion and unknown fever. Mycobacterium tuberculosis was not detected by culture of pleural effusion and sputum and gastric fluid. Pleural fluid was serous and exudative, and cytological examination showed no malignant cells. Computed tomography revealed a little pleural thickening of the right middle lobe and massive pleural effusion. As acute pleurisy was suspected based on the findings of imaging studies, thoracoscopy was performed under general anesthesia...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29754381/non-tuberculous-mycobacterial-infections-in-thoracic-transplant-candidates-and-recipients
#14
REVIEW
Mana Rao, Fernanda P Silveira
PURPOSE OF REVIEW: To review and discuss the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of non-tuberculous mycobacteria (NTM) in thoracic transplantation. RECENT FINDINGS: Non-tuberculous mycobacteria are ubiquitous but are an uncommon cause of disease after solid organ transplantation. The incidence of infection is higher in thoracic transplant recipients than in abdominal transplant recipients, with most cases seen after lung transplantation...
May 12, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29753789/diverse-cavity-types-and-evidence-that-mechanical-action-on-the-necrotic-granuloma-drives-tuberculous-cavitation
#15
Elizabeth A Ihms, Michael E Urbanowski, William R Bishai
Effacement of normal lung parenchyma by cavities is an important sequela of pulmonary tuberculosis. Despite its clinical significance, the pathogenesis of tuberculous cavitation is poorly understood, with controversy as to whether the fundamental mechanism involves matrix depletion, lipid pneumonia, or mechanical factors. In this study, a repetitive aerosol infection model using Mycobacterium tuberculosis was used to generate cavities in 20 New Zealand White rabbits. Serial computed tomography was performed to monitor cavity progression over 14 weeks...
May 10, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29752217/mass-spectrometric-identification-of-urinary-biomarkers-of-pulmonary-tuberculosis
#16
Flonza Isa, Sean Collins, Myung Hee Lee, Diessy Decome, Nancy Dorvil, Patrice Joseph, Lauren Smith, Stephen Salerno, Martin T Wells, Steven Fischer, James M Bean, Jean W Pape, Warren D Johnson, Daniel W Fitzgerald, Kyu Y Rhee
BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for development into point-of-care diagnostics. METHODS: We conducted a prospective case control study to identify candidate urine-based diagnostic biomarkers of active pulmonary TB (discovery cohort) and obtained a separate blinded "validation" cohort of confirmed cases of active pulmonary TB and controls with non-tuberculous pulmonary disease for validation...
April 22, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29750185/targeting-inflammatory-citokines-to-prevent-constriction-in-tuberculous-pericarditis-and-beyond
#17
EDITORIAL
Massimo Imazio
No abstract text is available yet for this article.
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29750184/effect-of-prednisolone-on-inflammatory-markers-in-pericardial-tuberculosis-a-pilot-study
#18
Justin Shenje, Rachel P Lai, Ian L Ross, Bongani M Mayosi, Robert J Wilkinson, Mpiko Ntsekhe, Katalin A Wilkinson
Background: Pericardial disorders are a common cause of heart disease, and the most common cause of pericarditis in developing countries is tuberculous (TB) pericarditis. It has been shown that prednisolone added to standard anti-TB therapy leads to a lower rate of constrictive pericarditis. We conducted a pilot study to evaluate the effect of adjunctive prednisolone treatment on the concentration of inflammatory markers in pericardial tuberculosis, in order to inform immunological mechanisms at the disease site...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29746443/presumed-tuberculous-multifocal-retinitis-in-patients-under-treatment-with-biologic-agents
#19
Tiago E Arantes, Luiz H Lima, Gláucio L Bressanin, Cláudia D Marques, Ângela B Duarte, Cristina Muccioli
PURPOSE: To report unique retinal fundus lesions and treatment outcomes of intraocular tuberculosis in patients under anti-tumor necrosis factor treatment. METHODS: Retrospective review of two patients with laboratorial evidence of tuberculosis who had bilateral ocular signs and symptoms not attributable to other diseases. Multimodal imaging was analyzed at the time of presentation and after the treatment initiation. The study patients underwent standard treatment for tuberculosis...
May 4, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29740544/establishment-of-a-host-to-host-transmission-model-for-mycobacterium-avium-subsp-hominissuis-using-caenorhabditis-elegans-and-identification-of-colonization-associated-genes
#20
Luiz E Bermudez, Sasha J Rose, Jamie L Everman, Navid R Ziaie
Mycobacterium avium subsp. hominissuis ( M. avium ) is a member of the non-tuberculous mycobacteria (NTM), and is a common cause of lung infection in patients with chronic NTM lung conditions. M. avium is an environmental bacterium believed to be transmitted from environmental sources. In this work we used a recently developed model in Caenorhabditis elegans to ask whether M. avium can be transmitted from host-to-host, and the bacterial genes associated with host colonization. Infection of C. elegans was carried out by placing the nematode in cultured with M...
2018: Frontiers in Cellular and Infection Microbiology
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