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https://www.readbyqxmd.com/read/28634555/a-rare-case-of-pneumopericardium-in-the-setting-of-tuberculous-constrictive-pericarditis
#1
Lauro L Abrahan Iv, Stephanie Martha O Obillos, Jaime Alfonso M Aherrera, Jose Donato A Magno, Celia Catherine C Uy-Agbayani, Ulysses King G Gopez, Jobelle Joyce Anne R Baldonado
A 28-year-old Filipino male was admitted due to high-grade fevers and dyspnea on a background of chronic cough and weight loss. Due to clinical and echocardiographic signs of cardiac tamponade, emergency pericardiocentesis was performed on his first hospital day. Five days after, chest radiographs showed new pockets of radiolucency within the cardiac shadow, indicative of pneumopericardium. On repeat echo, air microbubbles admixed with loculated effusion were visualized in the anterior pericardial space. Constrictive physiology was also supported by a thickened pericardium, septal bounce, exaggerated respiratory variation in AV valve inflow, and IVC plethora...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28633695/how-should-discordance-between-molecular-and-growth-based-assays-for-rifampicin-resistance-be-investigated
#2
S Hofmann-Thiel, H Hoffmann, D Hillemann, L Rigouts, A Van Deun, K Kranzer
Molecular tests to detect the presence of Mycobacterium tuberculosis and genetic polymorphisms in the rpoB gene conferring resistance to rifampicin (RMP) have become integral parts of tuberculosis diagnostics worldwide. These assays are often performed sequentially or in parallel to phenotypic drug susceptibility testing. Discordances between molecular and phenotypic tests invariably occur. Root causes range from pre-, post- and analytic errors to co-existence of non-tuberculous mycobacteria, silent mutations, mutations outside the 81 base-pair RMP resistance-determining region, non-canonical mutations conferring increased minimal inhibitory concentrations below the critical concentration in some phenotypic drug susceptibility tests, and heteroresistance...
July 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28630838/a-case-report-of-an-unusual-case-of-tuberculous-osteomyelitis-causing-spontaneous-pathological-fracture-of-humerus-in-a-middle-aged-female
#3
Umesh Birole, Ashish Ranade, Mahesh Mone
INTRODUCTION: Tuberculosis is a major health problem worldwide. Extrapulmonary tuberculosis is often secondary to some primary foci in lungs. There are reports of tuberculous osteomyelitis involving maxilla, ulna, femur, and shoulder joint but none have reported pathological fracture in humeral diaphysis due to tuberculosis osteomyelitis without shoulder joint involvement. We report a case of pathological fracture of humerus diaphysis due to tuberculous osteomyelitis with normal articular space...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28629484/outbreak-of-non-tuberculous-mycobacteria-skin-or-soft-tissue-infections-associated-with-handling-fish-new-york-city-2013-2014
#4
K Yacisin, J L Hsieh, D Weiss, J Ackelsberg, E Lee, L Jones, Y L Leung, L Li, J Yung, S Slavinski, H Hanson, A Ridpath, J Kornblum, Y Lin, S Robbe-Austerman, J Rakeman, U Siemetzki-Kapoor, T Stuber, S K Greene
Mycobacterium marinum, a bacterium found in freshwater and saltwater, can infect persons with direct exposure to fish or aquariums. During December 2013, the New York City Department of Health and Mental Hygiene learned of four suspected or confirmed M. marinum skin or soft tissue infections (SSTIs) among persons who purchased whole fish from Chinese markets. Ninety-eight case-patients with non-tuberculous mycobacteria (NTM) SSTIs were identified with onset June 2013-March 2014. Of these, 77 (79%) were female...
June 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28627685/metabolomic-analysis-based-on-1h-nuclear-magnetic-resonance-spectroscopy-metabolic-profiles-in-tuberculous-malignant-and-transudative-pleural-effusion
#5
Cheng Wang, Jingjin Peng, Yanling Kuang, Jiaqiang Zhang, Luming Dai
Pleural effusion is a common clinical manifestation with various causes. Current diagnostic and therapeutic methods have exhibited numerous limitations. By involving the analysis of dynamic changes in low molecular weight catabolites, metabolomics has been widely applied in various types of disease and have provided platforms to distinguish many novel biomarkers. However, to the best of our knowledge, there are few studies regarding the metabolic profiling for pleural effusion. In the current study, 58 pleural effusion samples were collected, among which 20 were malignant pleural effusions, 20 were tuberculous pleural effusions and 18 were transudative pleural effusions...
June 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627431/evaluation-of-the-quantamatrix-multiplexed-assay-platform-system-for-simultaneous-detection-of-mycobacteirum-tuberculosis-and-rifampicin-resistance-gene-using-culture-positive-mycobacteria
#6
Hye-Young Wang, Young Uh, Seoyong Kim, Tae-Sun Shim, Hyeyoung Lee
BACKGROUND: The differentiation of Mycobacterium tuberculosis complex (MTBC) from nontuberculous mycobacteria (NTM) is of primary importance for infection control and choice of anti-tuberculosis drugs. Prevailing data on rifampicin (RIF)-resistant TB is essential for early management of multidrug resistant-TB. The aim of this study was to evaluate the usefulness of a newly developed multiplexed, bead-based bioassay (Quantamatrix Multiplexed Assay Platform; QMAP) for the rapid differentiation of 23 Mycobacterium species including MTBC and RIF-resistant strains...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28626164/diagnostic-significance-of-measuring-vascular-endothelial-growth-factor-for-the-differentiation-between-malignant-and-tuberculous-pleural-effusion
#7
Hak-Ryul Kim, Byoung-Ryun Kim, Rae-Kil Park, Kwon-Ha Yoon, Eun-Taik Jeong, Ki-Eun Hwang
Malignancy and tuberculosis are common causes of lymphocytic exudative pleural effusion. However, it is occasionally difficult to differentiate malignant pleural effusion from tuberculous pleural effusion. Vascular endothelial growth factor (VEGF) is a critical cytokine in the pathogenesis of malignant pleural effusion. Endocan is a dermatan sulfate proteoglycan that is secreted by endothelial cells. Importantly, endocan mediates the vascular growth-promoting action of VEGF. The aim of this study was to evaluate the diagnostic significance of VEGF and endocan in pleural effusion...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28623874/lansoprazole-sulphide-pharmacokinetics-of-this-promising-anti-tuberculous-agent
#8
Sipho Mdanda, Sooraj Baijnath, Adeola Shobo, Sanil D Singh, Glenn E M Maguire, Hendrik G Kruger, Per I Arvidsson, Tricia Naicker, Thavendran Govender
Lansoprazole (LPZ) is a commercially available proton-pump inhibitor (PPI) whose primary metabolite, lansoprazole sulphide (LPZS) was recently reported to have in vitro and in vivo activity against M. tb. It was also reported that a 300 mg kg(-1) oral administration of LPZS was necessary to reach therapeutic levels in the lung, with the equivalent human dose being unrealistic. A validated liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for the simultaneous quantification LPZ and LPZS in rat plasma and lung homogenates, was developed...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28622866/pathology-and-genetic-findings-in-a-rare-case-of-mycobacterium-caprae-infection-in-a-sow
#9
Benedetta Amato, Teresa Maria Capucchio, Elena Biasibetti, Elena Mangano, Beatrice Maria Boniotti, Lodovica Maria Pacciarini, Sergio Migliore, Maria Vitale, Michele Fiasconaro, Vincenzo Di Marco Lo Presti
Bovine tuberculosis, a reemerging zoonosis in diverse ecological scenarios, has been reported in the autochthonous Nebrodi black pig breed population used for meat production in Italy. During a routine abattoir inspection in 2013, 24 of 299 carcasses (8%) of Nebrodi black pigs presented tuberculosis-like lesions at pathologic examination. Mycobacterium bovis was isolated from 23 animals and M. caprae from a 3-year-old sow. The sow showed severe diffuse lesions involving the visceral organs, right coxofemoral joint, and mammary glands...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28621250/tuberculous-bronchoesophageal-fistula-presenting-as-intractable-cough
#10
Venkatraman Indiran
Intractable cough is one of the debilitating conditions, which warrants immediate investigation to find out the underlying cause. There are numerous causes of intractable cough. We present one such young immunocompromised post renal transplant patient with pulmonary tuberculosis and severe uncontrolled cough due to bronchoesophageal fistula. Bronchoesophageal fistula representing abnormal communication between bronchus and esophagus is an uncommon condition. We emphasize the role of CT in such cases.
March 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28610790/mir-30c-is-specifically-repressed-in-patients-with-active-pulmonary-tuberculosis
#11
Silvana V Spinelli, Rocío Del V Fernández, Luciana Zoff, Bettina Bongiovanni, Ariana Díaz, Luciano D'Attilio, Natalia Santucci, Tomás Alvarez, Marcela M Marchesini, Cristina Bogue, Maria L Bay, Oscar A Bottasso
Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather benign manifestation of the disease. Patients with PLTB mount an effective anti-mycobacterial response, unlike those with active pulmonary TB (pTB) that were shown to present an imbalance in plasma immune and endocrine mediators. In this work, we explored whether expression of the active isoform of the glucocorticoid receptor (hGRα) in the context of the inflammatory-anti-inflammatory responses of TB patients may be associated to microRNA levels...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28610788/evaluation-of-antigen-specific-interleukin-1%C3%AE-as-a-biomarker-to-detect-cattle-infected-with-mycobacterium-bovis
#12
Mahmoud M Elnaggar, Gaber S Abdellrazeq, Alaa Elsisy, Asmaa H Mahmoud, Abdelrazeq Shyboub, Martina Sester, Samy A Khaliel, Mahavir Singh, Helmy A Torky, William C Davis
Bovine tuberculosis (bTB) is a major world-wide health problem that has been difficult to control, due to the lack of an effective vaccine and limited ability of the tuberculin skin test (TST) and the ancillary whole blood interferon-gamma (IFN-γ) release assay (IGRA) to detect all infected animals. A 6 h cytokine flow cytometric IFN-γ (CFC) assay was developed in effort to overcome these limitations and expand methods for studying the mechanisms of bTB immunopathogenesis. The present study was conducted to evaluate IL-1β as a biomarker to use in conjunction with the IFN-γ CFC assay to improve the diagnostic accuracy for bTB...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28610163/a-new-small-bent-toed-gecko-of-the-genus-i-cyrtodactylus-i-squamata-gekkonidae-from-the-lower-slopes-of-mount-tambora-sumbawa-island-indonesia
#13
Awal Riyanto, Mulyadi Mulyadi, Jimmy A McGuire, Mirza D Kusrini, Febylasmia Febylasmia, Irfan Haidar Basyir, Hinrich Kaiser
We describe the sixth species of bent-toed gecko from the Lesser Sunda Islands, Indonesia. This species was first collected on the banks of the Oi Marai River on the low northern slopes of Gunung (Mount) Tambora on Sumbawa Island. The new species is differentiated from Greater Sunda Islands (including Sulawesi) and Lesser Sunda Islands congeners by having the following unique combination of characters: (1) two scales between the second pair of postmentals in contact with the first pair; (2) dorsal surface of antebrachium tuberculate; (3) no tubercles on dorsal surface of brachium; (4) dorsal surfaces of thigh and crus tuberculate; (5) 18 irregularly aligned, longitudinal rows of keeled tubercles at midbody; (6) 26-27 paravertebral tubercles; (7) 40 ventral scales between indistinct ventrolateral folds; (8) 16-17 fourth-toe subdigital scales; (9) a continuous enlarged precloacal and femoral scales present, with the enlarged femoral scales arranged in three rows; (10) males with five to six precloacal pores, with four larger pores situated in a short groove; (11) femoral pores absent in both sexes; (12) lack of transversely enlarged subcaudal scales; and (13) 7-9 irregular, paired black blotches on the body...
March 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610143/a-new-species-of-i-leptolalax-i-anura-megophryidae-from-northern-vietnam
#14
Jodi J L Rowley, Vinh Q Dau, Huy D Hoang, Duong T T LE, Timothy P Cutajar, Tao T Nguyen
We describe a new, medium-sized Leptolalax species from Vietnam. Leptolalax petrops sp. nov. is distinguished from its congeners by a combination of having a medium-sized body (23.6-27.6 mm in 21 adult males, 30.3-47.0 mm in 17 adult females), immaculate white chest and belly, no distinct black markings on the head, highly tuberculate skin texture, toes lacking webbing and with narrow lateral fringes, and a call consisting of an average of four notes and a dominant frequency of 5.6-6.4 kHz (at 24.5-25.3 °C)...
March 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610138/-i-cambarus-i-i-c-i-i-appalachiensis-i-a-new-species-of-crayfish-decapoda-cambaridae-from-the-new-river-basin-of-virginia-and-west-virginia-usa
#15
Zachary J Loughman, Stuart A Welsh, Roger F Thoma
Cambarus (Cambarus) appalachiensis is a stream-dwelling crayfish endemic to the greater New River basins of Virginia and West Virginia. The new species is morphologically most similar to Cambarus sciotensis. Cambarus appalachiensis can be differentiated from C. sciotensis by its more elongated chelae which possess a single mesial row of tubercles, reduced to no tuberculation on the dorsal-longitudinal ridge of the dactyl, and reduced lateral impression. Cambarus sciotensis has a more subrectangular chelae with two rows of mesial margin tubercles on the chelae, as well as both a pronounced dorsal-longitudinal ridge and pronounced lateral impression...
March 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609931/a-new-subfamily-of-feaellidae-arachnida-chelonethi-feaelloidea-from-southeast-asia
#16
Mark L I Judson
The first extant representatives of the pseudoscorpion family Feaellidae from Southeast Asia are described. Cybella n. gen. is proposed for Cybella deharvengi n. sp. (type species), collected from an isolated limestone hill in Hon Chong Province, Vietnam, and C. bedosae n. sp., found in a limestone cave in Kampuchea, Cambodia. Cybella species seem to be restricted to karst formations and are probably troglophilic. The type localities of the two known species are threatened by quarrying activities, these being particularly pressing in the case of C...
April 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608659/is-the-initial-size-of-tuberculous-lymphadenopathy-associated-with-lymph-node-enlargement-during-treatment
#17
Yun Jae Seol, Se Yoon Park, Shi Nae Yu, Tark Kim, Eun Jung Lee, Min Huok Jeon, Eun Ju Choo, Tae Hyong Kim
There are little data on the changes in lymph node (LN) size during the treatment of tuberculous lymphadenopathy (TB LAP). This study aimed to provide data on LN changes during treatment. Between March 2014 and December 2015, 20 patients who were diagnosed with cervical TB LAP were enrolled. LN enlargement within two months (50%, 4/8 vs. 8.3%, 1/12; P = 0.04) was more frequently observed in patients with initial LN size ≥ 7.5 cm². Enlarged LNs were excised in three patients owing to pain and fistula formation...
May 24, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28606665/tuberculous-limbic-encephalitis-a-case-report
#18
M Toudou Daouda, N S Obenda, Z Souirti
No abstract text is available yet for this article.
June 9, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28605426/biomarkers-of-cerebral-injury-and-inflammation-in-pediatric-tuberculous-meningitis
#19
Ursula K Rohlwink, Katya Mauff, Katalin A Wilkinson, Nico Enslin, Emmanuel Wegoye, Robert J Wilkinson, Anthony A Figaji
Background: Tuberculous meningitis (TBM) leads to death or disability in half the affected individuals. Tools to assess severity and predict outcome are lacking. Neuro-specific biomarkers could serve as markers of the severity and evolution of brain injury, but have not been widely explored in TBM. We examined biomarkers of neurological injury (neuromarkers) and inflammation in pediatric TBM and their association with outcome. Methods: Blood and cerebrospinal fluid (CSF) of children with TBM and hydrocephalus taken on admission and over 3 weeks were analysed for neuromarkers S100B, neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP), and multiple inflammatory markers...
June 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28605283/interferon-%C3%AE-controls-non-tuberculous-mycobacterial-infection-in-mice
#20
Mohd-Nor Norazmi
No abstract text is available yet for this article.
June 12, 2017: Virulence
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