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https://www.readbyqxmd.com/read/28820428/pharmacokinetic-analysis-of-an-oral-multicomponent-joint-dietary-supplement-phycox-%C3%A2-in-dogs
#1
Stephanie E Martinez, Ryan Lillico, Ted M Lakowski, Steven A Martinez, Neal M Davies
Despite the lack of safety, efficacy and pharmacokinetic (PK) studies, multicomponent dietary supplements (nutraceuticals) have become increasingly popular as primary or adjunct therapies for clinical osteoarthritis in veterinary medicine. Phycox(®) is a line of multicomponent joint support supplements marketed for joint health in dogs and horses. Many of the active constituents are recognized anti-inflammatory and antioxidant agents. Due to a lack of PK studies in the literature for the product, a pilot PK study of select constituents in Phycox(®) was performed in healthy dogs...
August 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28817105/bioactive-compounds-from-mexican-varieties-of-the-common-bean-phaseolus-vulgaris-implications-for-health
#2
REVIEW
Celia Chávez-Mendoza, Esteban Sánchez
As Mexico is located within Mesoamerica, it is considered the site where the bean plant originated and where it was domesticated. Beans have been an integral part of the Mexican diet for thousands of years. Within the country, there are a number of genotypes possessing highly diverse physical and chemical properties. This review describes the major bioactive compounds contained on the Mexican varieties of the common bean. A brief analysis is carried out regarding the benefits they have on health. The effect of seed coat color on the nutraceutical compounds content is distinguished, where black bean stands out because it is high content of anthocyanins, polyphenols and flavonoids such as quercetin...
August 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28814829/antibiotic-susceptibility-heteroresistance-and-updated-treatment-strategies-in-helicobacter-pylori-infection
#3
REVIEW
Maria Teresa Mascellino, Barbara Porowska, Massimiliano De Angelis, Alessandra Oliva
In this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in Helicobacter pylori (Hp) eradication, as well as the updated treatment strategies for this infection. The prevalence of antibiotic resistance is increasing all over the world, especially for metronidazole and clarithromycin, because of their heavy use in some geographical areas. Heteroresistance (simultaneous presence of both susceptible and resistant strains in different sites of a single stomach) is another important issue, as an isolate could be mistakenly considered susceptible if a single biopsy is used for antimicrobial tests...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28814124/comparative-metabolic-profiling-of-costus-speciosus-leaves-and-rhizomes-using-nmr-gc-ms-and-uplc-esi-ms-ms
#4
Ashish Kumar, Antim K Maurya, Gopi Chand, Vijai K Agnihotri
Costus speciosus had been used in oriental systems of medicines, to treat diverse ailments. The present study was focused on NMR, GC-MS and UPLC/ESI-MS/MS-based metabolic profiling of C. speciosus. This metabolic study resulted in the identification of 91 and quantification of 69 metabolites. Caffeic acid derivatives previously unreported in C. speciosus were also identified. High quantity of steroidal saponins namely methyl protogracillin (297.97 ± 0.07 mg/g dried wt.) and dioscin (158.72 ± 0.27 mg/g dried wt...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28813148/chitosan-coated-cinnamon-oregano-loaded-solid-lipid-nanoparticles-to-augment-5-fluorouracil-cytotoxicity-for-colorectal-cancer-extracts-standardization-nanoparticles-optimization-and-cytotoxicity-evaluation
#5
Kamel M Kamel, Islam A Khalil, Mostafa E Rateb, Hosieny Elgendy, Seham Elhawary
This study aimed to coat lipid-based-nanocarriers with chitosan to encapsulate nutraceuticals, minimize opsonization and facilitate passive-targeting. Phase-one was concerned with standardization according to WHO. Qualitative-analysis using LC-HRMS/MS investigated the active-constituents especially reported cytotoxic-agents. Cinnamaldehyde and rosmarinic acid was selected to be quantified using HPLC. Phase-two was aimed to encapsulate both extracts in solid lipid nanoparticles (core) and chitosan (shell) to gain the advantages of both materials properties...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#6
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28811228/curcumin-in-alzheimer-s-disease-can-we-think-to-new-strategies-and-perspectives-for-this-molecule
#7
REVIEW
Serafini Melania Maria, Catanzaro Michele, Rosini Michela, Racchi Marco, Lanni Cristina
Population aging is an irreversible global trend with economic and socio-political consequences. One of the most invalidating outcomes of aging in the elderly is cognitive decline, leading to dementia and often related to neurodegenerative disorders. Among these latter, Alzheimer's disease (AD) is the major cause of dementia, affecting more than 30 million of individuals worldwide. To date, the treatment of AD remains a challenge because of an incomplete understanding of the events that lead to the selective neurodegeneration typical of Alzheimer's brains...
August 12, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28809450/microalgae-old-sustainable-food-and-fashion-nutraceuticals
#8
José L García, Marta de Vicente, Beatriz Galán
Microalgae have been used for centuries to provide nourishment to humans and animals, only very recently they have become much more widely cultured and harvested at large industrial scale. This paper reviews the potential health benefits and nutrition provided by microalgae whose benefits are contributing to expand their market. We also point out several key challenges that remain to be addressed in this field.
August 15, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28805832/encapsulation-of-flavonoids-in-liposomal-delivery-systems-the-case-of-quercetin-kaempferol-and-luteolin
#9
Meigui Huang, Erzheng Su, Fuping Zheng, Chen Tan
The instability of dietary flavonoids is currently a challenge for their incorporation in functional foods. This study investigated the protective effects of liposome encapsulation on a variety of flavonoids and their interaction mechanisms. It was found that the incorporation of flavonoids into the liposomal membrane was strongly dependent on their structure and loading concentration. Liposomes loading quercetin and luteolin exhibited a relatively small size and homogeneous suspension compared to those loading kaempferol...
August 14, 2017: Food & Function
https://www.readbyqxmd.com/read/28805683/analysis-and-comparison-of-the-antioxidant-component-of-portulaca-oleracea-leaves-obtained-by-different-solid-liquid-extraction-techniques
#10
Monica Gallo, Esterina Conte, Daniele Naviglio
Portulaca oleracea is a wild plant pest of orchards and gardens, but is also an edible vegetable rich in beneficial nutrients. It possesses many antioxidant properties due to the high content of vitamins, minerals, omega-3 essential fatty acids and other healthful compounds; therefore, the intake of purslane and/or its bioactive compounds could help to improve the health and function of the whole human organism. Accordingly, in this work it was analyzed and compared to the extractive capacity of the antioxidant component of purslane leaves obtained by solid-liquid extraction techniques such as: hot-maceration, maceration with ultrasound, rapid solid-liquid dynamic extraction using the Naviglio extractor, and a combination of two techniques (mix extraction)...
August 12, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28805459/opuntia-ficus-indica-l-miller-as-a-source-of-bioactivity-compounds-for-health-and-nutrition
#11
M Aragona, E R Lauriano, S Pergolizzi, C Faggio
Plants with beneficial properties are known in traditional medicine. Nowadays, in spite of widespread availability of synthetic compounds, the search goes towards natural compounds to lower cost and few side effects. The increasing interest in preventive medicine encourages use of nutraceuticals, bioactive compounds of vegetable origin with important nutritional values. Among the medicinal plants, Opuntia ficus-indica (L.) Miller (Family Cactaceae, subfamily Opuntiodeae, Genus Opuntia, subgenus Platyopuntia, species Opuntia ficus-indica (L...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28803136/anti-inflammatory-activity-of-natural-stilbenoids-a-review
#12
REVIEW
Marcela Dvorakova, Premysl Landa
Resveratrol and other natural stilbenoids, including piceatannol, pterostilbene, and gnetol, are well-known anti-inflammatory compounds with indisputable activity in vitro as well as in vivo. Their molecular targets include inducible nitric oxide synthase, cyclooxygenases, leukotrienes, nuclear factor kappa B, tumor necrosis factor α, interleukins and many more. This anti-inflammatory activity together with their antioxidant activity is believed to stand behind their other positive health effects against cancer, cardiovascular and neurodegenerative diseases or diabetes...
August 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28802473/integrative-women-s-health
#13
REVIEW
Delia Chiaramonte, Melinda Ring, Amy B Locke
This article addresses the common women's health concerns of menopause-related symptoms, premenstrual syndrome, and chronic pelvic pain. Each can be effectively addressed with an integrative approach that incorporates interventions such as pharmaceuticals, nutraceuticals, mind-body approaches, acupuncture, and lifestyle modification.
September 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28801966/ursolic-acid-a-natural-nutraceutical-agent-targets-caspase3-and-alleviates-inflammation-associated-downstream-signal-transduction
#14
Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou, Gang Bai
SCOPE: Ursolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal transduction processes linked to the anti-inflammation pathway have not been thoroughly elucidated to date. METHODS AND RESULTS: Chemical biology strategies such as target fishing, click reaction synthesis of a UA probe and molecular imaging were used to identify potential target proteins of UA...
August 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28800398/a-13-week-randomized-pilot-trial-of-a-low-glycemic-load-diet-and-lifestyle-modification-program-combining-low-glycemic-load-protein-shakes-and-targeted-nutraceuticals-improved-weight-loss-and-cardio-metabolic-risk-factors-over-a-low-glycemic-load-diet-alone
#15
Clinton J Dahlberg, Joseph J Ou, John G Babish, Joseph J Lamb, Sarah Eliason, Holly Brabazon, Wei Gao, Mohan R Kaadige, Matthew L Tripp
An open label, randomized, exploratory study comprising 44 healthy, overweight subjects with cardio-metabolic syndrome (CMS) risk factors was conducted to assess the safety, tolerability and efficacy of a proprietary lifestyle modification program without (DIET) and with (PROG) targeted nutraceutical supplementation including soy, pea and whey proteins, phytosterols, antioxidants, probiotics, fish oil and berberine over 13-weeks. Key metrics were recorded at baseline, weeks 9 and 13. For DIET and PROG compliance was 85% and 86%, respectively, with no adverse events related to the diet or supplements...
August 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28799778/how-important-is-tryptophan-in-human-health
#16
Joanna Kałużna-Czaplińska, Paulina Gątarek, Salvatore Chirumbolo, Max Stanley Chartrand, Geir Bjørklund
Tryptophan (Trp) is an amino acid and an essential component of the human diet. It plays a crucial role in many metabolic functions. Clinicians can use Trp levels in the course of diagnosing various metabolic disorders and the symptoms associated with those diseases. Furthermore, supplementation with this amino acid is considered in the treatment of depression and sleep disorders, mainly due to the Trp relationship with the synthesis of serotonin (5-HT) and melatonin. It is also used in helping to resolve cognitive disorders, anxiety, or neurodegenerative diseases...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28799667/coadministration-of-isomalto-oligosaccharides-augments-metabolic-health-benefits-of-cinnamaldehyde-in-high-fat-diet-fed-mice
#17
Dhirendra Pratap Singh, Pragyanshu Khare, Vandana Bijalwan, Ritesh Kumar Baboota, Jagdeep Singh, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Bacteriostatic properties of a potential anti-obesity agent cinnamaldehyde (CMN) may present untoward effects on the resident gut microbiota. Here, we evaluated whether the combination of Isomalto-oligosaccharides (IMOs) with CMN prevents unwanted effects of CMN on gut microbiota and associated metabolic outcomes in HFD-fed mice. Male Swiss albino mice divided into four groups (n = 10), were fed on normal chow, or HFD (58% fat kcal), HFD + CMN (10 mg kg(-1) ) and HFD + CMN (10 mg kg(-1) ) + IMOs (1 g kg(-1) ) for 12 weeks...
August 11, 2017: BioFactors
https://www.readbyqxmd.com/read/28799642/olive-tree-olea-europaea-l-leaf-as-a-waste-by-product-of-table-olive-and-olive-oil-industry-a-review
#18
REVIEW
Selin Şahin, Mehmet Bilgin
Researches into finding new uses for by-products of table olive and olive oil industry are of great value not only to the economy, but also to the environment where olives are grown and to the human health. Since leaves represent around 10% of the total weight of olives arriving to the mill, it is worth obtaining high added-value compounds from those materials for the preparation of dietary supplements, nutraceuticals, functional food ingredients or cosmeceuticals. In this review article, olive tree (Olea europaea L...
August 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28798909/analysis-of-urine-composition-in-type-ii-diabetic-mice-after-intervention-therapy-using-holothurian-polypeptides
#19
Yanyan Li, Jiajie Xu, Xiurong Su
Hydrolysates and peptide fractions (PF) obtained from sea cucumber with commercial enzyme were studied on the hyperglycemic and renal protective effects on db/db rats using urine metabolomics. Compared with the control group the polypeptides from the two species could significantly reduce the urine glucose and urea. We also tried to address the compositions of highly expressed urinary proteins using a proteomics approach. They were serum albumins, AMBP proteins, negative trypsin, elastase, and urinary protein, GAPDH, a receptor of urokinase-type plasminogen activator (uPAR), and Ig kappa chain C region...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28795322/discarded-seeds-from-red-pepper-capsicum-annum-processing-industry-as-a-sustainable-source-of-high-added-value-compounds-and-edible-oil
#20
Samia Azabou, Fadia Ben Taheur, Mourad Jridi, Mohamed Bouaziz, Moncef Nasri
The chemical composition and the antioxidant properties of Capsicum annum discarded seeds from processing industry with their corresponding extracted oil were investigated. C. annum seeds had high levels of crude proteins (18.30%), crude oil (11.04%), and dietary fibers (60.96%). The lipophilic fraction of C. annum seeds showed higher radical scavenging activity compared to their hydrophilic fraction, while this latter exhibited the highest reducing power. The results of fatty acid composition showed that fatty acids present in C...
August 9, 2017: Environmental Science and Pollution Research International
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