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https://www.readbyqxmd.com/read/27871905/the-behavioural-and-neuroprotective-outcomes-when-670nm-and-810nm-near-infrared-light-are-applied-together-in-mptp-treated-mice
#1
Florian Reinhart, Nabil El Massri, Napoleon Torres, Claude Chabrol, Jenny Molet, Daniel M Johnstone, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis, Cécile Moro
We have shown previously that when applied separately, 670nm and 810nm near infrared light (NIr) reduces behavioural deficits and offers neuroprotection in a MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. Here, we explored the beneficial outcomes when these NIr wavelengths were applied both together, either concurrently (at the same time) or sequentially (one after the other). Mice received MPTP injections (total of 50mg/kg) and had extracranial application of 670nm and/or 810nm NIr...
November 18, 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27696408/widespread-brain-transcriptome-alterations-underlie-the-neuroprotective-actions-of-dietary-saffron
#2
Nicholas V Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas J Burton, John Mitrofanis, Jonathan Stone, Daniel M Johnstone
Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for 2, 5 or 10 days before administration of the parkinsonian neurotoxin MPTP (50 mg/kg)...
October 1, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27396907/effects-of-a-higher-dose-of-near-infrared-light-on-clinical-signs-and-neuroprotection-in-a-monkey-model-of-parkinson-s-disease
#3
Cécile Moro, Nabil El Massri, Fannie Darlot, Napoleon Torres, Claude Chabrol, Diane Agay, Vincent Auboiroux, Daniel M Johnstone, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid
We have reported previously that intracranial application of near-infrared light (NIr) - when delivered at the lower doses of 25J and 35J - reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether a higher NIr dose (125J) generated beneficial effects in the same MPTP monkey model (n=15). We implanted an NIr (670nm) optical fibre device within a midline region of the midbrain in macaque monkeys, close to the substantia nigra of both sides...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27377070/near-infrared-light-treatment-reduces-astrogliosis-in-mptp-treated-monkeys
#4
Nabil El Massri, Cécile Moro, Napoleon Torres, Fannie Darlot, Diane Agay, Claude Chabrol, Daniel M Johnstone, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis
We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry...
July 5, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27262035/reply
#5
John Mitrofanis, Cécile Moro, Alim-Louis Benabid
No abstract text is available yet for this article.
August 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27190635/two-dimensional-cutting-tdc-vitrectome-in-vitro-flow-assessment-and-prospective-clinical-study-evaluating-core-vitrectomy-efficiency-versus-standard-vitrectome
#6
Mitrofanis Pavlidis
Purpose. To evaluate comparative aspiration flow performance and also vitrectomy operating time efficiency using a double-cutting open port vitreous cutting system incorporated in a two-dimensional cutting (TDC, DORC International) vitrectome design versus standard vitreous cutter. Methods. In vitro investigations compared aspiration flow rates in artificial vitreous humor at varying cutter speeds and vacuum levels using a TDC vitrectome and a standard vitrectome across different aspiration pump systems. A prospective single-centre clinical study evaluated duration of core vitrectomy in 80 patients with macular pucker undergoing 25-gauge or 27-gauge vitrectomy using either a TDC vitrectome at 16,000 cuts per minute (cpm) or standard single-cut vitrectome, combined with a Valve Timing intelligence (VTi) pump system (EVA, DORC International)...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27105327/surgical-and-functional-results-of-27-gauge-vitrectomy-combined-with-coaxial-1-8-mm-microincision-cataract-surgery-a-consecutive-case-series
#7
Mitrofanis Pavlidis, Norbert Körber, Fabian Höhn
PURPOSE: To investigate outcomes after coaxial 1.8 mm microincision cataract surgery combined with 27-gauge vitrectomy (MICVIT) in eyes with vitreoretinal disease and age-related cataract. METHODS: A single-center, retrospective case series study of 62 subjects (62 eyes) with a mean age of 70 years who underwent combined microincision phacoemulsification, intraocular lens implantation, and 27-gauge vitrectomy during the 12-month period to January 2015. Intraoperative and postoperative complications, and visual results were the main outcome measures...
April 21, 2016: Retina
https://www.readbyqxmd.com/read/26966558/surgical-and-functional-results-of-hybrid-25-27-gauge-vitrectomy-combined-with-coaxial-2-2%C3%A2-mm-small-incision-cataract-surgery
#8
Fabian Höhn, Florian Kretz, Mitrofanis Pavlidis
Purpose. To investigate outcomes after coaxial 2.2 mm small incision cataract surgery combined with hybrid 25-27-gauge vitrectomy in eyes with vitreoretinal disease and age-related cataract. Methods. A single-center, retrospective case series study of 55 subjects (55 eyes) with a mean age of 70 years who underwent combined small incision phacoemulsification, intraocular lens (IOL) implantation, and hybrid 25-27-gauge vitrectomy during the 12-month period to December 2014. Intraoperative and postoperative complications and visual results were the main outcome measures...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26879772/near-infrared-light-670%C3%A2-nm-reduces-mptp-induced-parkinsonism-within-a-broad-therapeutic-time-window
#9
Florian Reinhart, Nabil El Massri, Daniel M Johnstone, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid, Cécile Moro
We have shown previously that near-infrared light (NIr), when applied at the same time as a parkinsonian insult (e.g. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP), reduces behavioural deficits and offers neuroprotection. Here, we explored whether the timing of NIr intervention-either before, at the same time or after the MPTP insult-was important. Mice received MPTP injections (total of 50 mg/kg) and, at various stages in relation to these injections, extracranial application of NIr. Locomotor activity was tested with an open-field test, and brains were processed for immunohistochemistry...
July 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/26793049/turning-on-lights-to-stop-neurodegeneration-the-potential-of-near-infrared-light-therapy-in-alzheimer-s-and-parkinson-s-disease
#10
REVIEW
Daniel M Johnstone, Cécile Moro, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis
Alzheimer's and Parkinson's disease are the two most common neurodegenerative disorders. They develop after a progressive death of many neurons in the brain. Although therapies are available to treat the signs and symptoms of both diseases, the progression of neuronal death remains relentless, and it has proved difficult to slow or stop. Hence, there is a need to develop neuroprotective or disease-modifying treatments that stabilize this degeneration. Red to infrared light therapy (λ = 600-1070 nm), and in particular light in the near infrared (NIr) range, is emerging as a safe and effective therapy that is capable of arresting neuronal death...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26613166/intracranial-application-of-near-infrared-light-in-a-hemi-parkinsonian-rat-model-the-impact-on-behavior-and-cell-survival
#11
Florian Reinhart, Nabil El Massri, Claude Chabrol, Celine Cretallaz, Daniel M Johnstone, Napoleon Torres, Fannie Darlot, Thomas Costecalde, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid, Cécile Moro
OBJECT The authors of this study used a newly developed intracranial optical fiber device to deliver near-infrared light (NIr) to the midbrain of 6-hydroxydopamine (6-OHDA)-lesioned rats, a model of Parkinson's disease. The authors explored whether NIr had any impact on apomorphine-induced turning behavior and whether it was neuroprotective. METHODS Two NIr powers (333 nW and 0.16 mW), modes of delivery (pulse and continuous), and total doses (634 mJ and 304 J) were tested, together with the feasibility of a midbrain implant site, one considered for later use in primates...
June 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26504597/determination-of-a-new-parameter-elevated-epiretinal-membrane-by-en-face-oct-as-a-prognostic-factor-for-pars-plana-vitrectomy-and-safer-epiretinal-membrane-peeling
#12
Mitrofanis Pavlidis, Ilias Georgalas, Norbert Körber
Purpose. To evaluate the significance of the area of epiretinal membrane (EM) that is not in contact with the retinal structure as a preoperative parameter for safer grasping of the EM and a prognostic factor for visual improvement/outcome. Methods. This prospective observational study included 73 consecutive patients (80 eyes) who underwent pars plana vitrectomy (PPV) and EM peeling. Corrected distance visual acuity (CDVA) and central foveal thickness (CFT) were evaluated preoperatively and at 12 months postoperatively...
2015: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26456231/near-infrared-light-is-neuroprotective-in-a-monkey-model-of-parkinson-disease
#13
Fannie Darlot, Cécile Moro, Nabil El Massri, Claude Chabrol, Daniel M Johnstone, Florian Reinhart, Diane Agay, Napoleon Torres, Dhaïf Bekha, Vincent Auboiroux, Thomas Costecalde, Cassandra L Peoples, Helena D T Anastascio, Victoria E Shaw, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid
OBJECTIVE: To examine whether near-infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model of Parkinson disease. METHODS: We implanted an optical fiber device that delivered NIr (670 nm) to the midbrain of macaque monkeys, close to the substantia nigra of both sides. MPTP injections (1.5-2.1mg/kg) were made over a 5- to 7-day period, during which time the NIr device was turned on...
January 2016: Annals of Neurology
https://www.readbyqxmd.com/read/25878572/targeting-the-body-to-protect-the-brain-inducing-neuroprotection-with-remotely-applied-near-infrared-light
#14
Daniel M Johnstone, John Mitrofanis, Jonathan Stone
No abstract text is available yet for this article.
March 2015: Neural Regeneration Research
https://www.readbyqxmd.com/read/25703226/near-infrared-light-mitigates-cerebellar-pathology-in-transgenic-mouse-models-of-dementia
#15
Sivaraman Purushothuman, Daniel M Johnstone, Charith Nandasena, Janet van Eersel, Lars M Ittner, John Mitrofanis, Jonathan Stone
We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice...
March 30, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/25469453/the-effect-of-different-doses-of-near-infrared-light-on-dopaminergic-cell-survival-and-gliosis-in-mptp-treated-mice
#16
COMPARATIVE STUDY
Nabil El Massri, Daniel M Johnstone, Cassandra L Peoples, Cécile Moro, Florian Reinhart, Napoleon Torres, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis
We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose...
2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/25462595/810nm-near-infrared-light-offers-neuroprotection-and-improves-locomotor-activity-in-mptp-treated-mice
#17
Florian Reinhart, Nabil El Massri, Fannie Darlot, Napoleon Torres, Daniel M Johnstone, Claude Chabrol, Thomas Costecalde, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid, Cécile Moro
We explored whether 810nm near-infrared light (NIr) offered neuroprotection and/or improvement in locomotor activity in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. Mice received MPTP and 810nm NIr treatments, or not, and were tested for locomotive activity in an open-field test. Thereafter, brains were aldehyde-fixed and processed for tyrosine hydroxylase immunohistochemistry. Our results showed that MPTP-treated mice that were irradiated with 810nm NIr had both greater locomotor activity (∼40%) and number of dopaminergic cells (∼20%) than those that were not...
March 2015: Neuroscience Research
https://www.readbyqxmd.com/read/25318547/the-mechanical-cause-of-age-related-dementia-alzheimer-s-disease-the-brain-is-destroyed-by-the-pulse
#18
REVIEW
Jonathan Stone, Daniel M Johnstone, John Mitrofanis, Michael O'Rourke
This review traces evidence that age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/25199990/orbital-burkitt-lymphoma-a-case-presentation
#19
Chichua Alexander, Chichua George, Jikurashvili Tinatin, Saginashvili Maia, Mchedlishvili Maia, Pavlidis Mitrofanis
BACKGROUND: Highly aggressive Burkitt lymphoma (BL) with rapidly progressive painful proptosis of the right eye is rarely encountered. CASE PRESENTATION: A 31-year-old Caucasian female presented with rapidly progressive painful proptosis of the right eye and poor visual acuity. Diagnostic Computer tomography, magnetic resonance imagining and angiography, identified an oval-shaped mass on the medial rectus of the right orbit that caused dislocation of eyeball, for which she underwent medial orbitotomy...
2014: BMC Ophthalmology
https://www.readbyqxmd.com/read/24986885/sudden-unilateral-painless-loss-of-vision
#20
Ilias Georgalas, Dionisis Pagoulatos, Chryssanthi Koutsandrea, Mitrofanis Pavlidis
No abstract text is available yet for this article.
July 1, 2014: BMJ: British Medical Journal
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