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https://www.readbyqxmd.com/read/29750947/glaucoma-specialist-optic-disc-margin-rim-margin-and-rim-width-discordance-in-glaucoma-and-glaucoma-suspect-eyes
#1
Seung Woo Hong, Helen Koenigsman, Ruojin Ren, Hongli Yang, Stuart K Gardiner, Juan Reynaud, Robert M Kinast, Steven L Mansberger, Brad Fortune, Shaban Demirel, Claude F Burgoyne
PURPOSE: To quantify the variability of 5 glaucoma specialists' optic disc margin (DM), rim margin (RM) and rim width (RW) estimates. DESIGN: Inter-Observer Reliability analysis. METHODS: Clinicians viewed stereo-photos from 214 subjects with glaucoma or ocular hypertension and digitally marked the DM and RM. For each photo, the centroid of each clinician's DM was calculated, and an averaged DMcentroid was determined. The axis between the DMcentroid and the fovea was used to establish twelve 30° sectors...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29740064/tortuous-pore-path-through-the-glaucomatous-lamina-cribrosa
#2
Bo Wang, Katie A Lucy, Joel S Schuman, Ian A Sigal, Richard A Bilonick, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, Zachary Nadler, Hiroshi Ishikawa, Larry Kagemann, James G Fujimoto, Gadi Wollstein
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664832/optical-coherence-tomography-angiography-macular-vascular-density-measurements-and-the-central-10-2-visual-field-in-glaucoma
#3
Rafaella C Penteado, Linda M Zangwill, Fábio B Daga, Luke J Saunders, Patricia Isabel C Manalastas, Takuhei Shoji, Tadamichi Akagi, Mark Christopher, Adeleh Yarmohammadi, Sasan Moghimi, Robert N Weinreb
PURPOSE: To evaluate the association between macula vascular density assessed by optical coherence tomography angiography (OCT-A) and central visual field (VF) threshold sensitivities in healthy, glaucoma suspect and glaucoma patients. METHODS: A total of 185 eyes from 38 healthy participants, 31 glaucoma suspects, 72 mild glaucoma patients, and 44 moderate/severe glaucoma patients from the Diagnostic Innovations in Glaucoma Study who underwent OCT-A images of the macula and 10-2 VF testing were enrolled in this observational cross-sectional study...
April 16, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29657981/acceptability-and-use-of-glaucoma-virtual-clinics-in-the-uk-a-national-survey-of-clinical-leads
#4
Patrick J G Gunn, Joanne R Marks, Leon Au, Heather Waterman, Paul G D Spry, Robert A Harper
Objective: The purpose of this paper is to describe the findings of a national survey that aimed to estimate the proportion of Hospital Eye Service (HES) units using glaucoma virtual clinics, to determine how these services differ and to gauge clinicians' views and opinions on the safety and acceptability of this model of care compared with usual care. Methods and analysis: This 12-question survey was disseminated nationally to 92 clinical lead consultant ophthalmologists using SurveyMonkey...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29616408/difference-in-intraocular-pressure-measurements-between-non-contact-tonometry-and-goldmann-applanation-tonometry-and-the-role-of-central-corneal-thickness-in-affecting-glaucoma-referrals
#5
Khalid Kamel, Edward Dervan, Kevin Falzon, Colm O'Brien
BACKGROUND: Patients at glaucoma risk are commonly identified by optometrists and subsequently referred to glaucoma specialists. Optometrists mainly use non-contact tonometry (NCT) for intraocular pressure (IOP) measurement. AIMS: To investigate the role of differences in IOP measurement between NCT and Goldmann applanation tonometry (GAT) and the effect of central corneal thickness (CCT) on these differences in optometrist referrals METHODS: Details of the initial clinical visit of patients referred with IOP > 21 mmHg in either eye as measured by NCT to a consultant glaucoma specialist were retrospectively reviewed...
April 4, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29582810/evaluation-of-macular-ganglion-cell-analysis-compared-to-retinal-nerve-fiber-layer-thickness-for-preperimetric-glaucoma-diagnosis
#6
Sushmita Kaushik, Pankaj Kataria, Vaibhav Jain, Gunjan Joshi, Srishti Raj, Surinder Singh Pandav
Purpose: To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma. Methods: A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better than -6.0 D), 150 glaucoma suspects (106 with suspicious discs and 44 ocular hypertensive (OHT), and 78 normal controls was done. Eligible participants were scanned with the spectral domain CirrusTM OCT (Carl Zeiss Meditec, Dublin, CA)...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29582809/concomitant-use-of-conjunctival-tissue-graft-from-the-pterygium-itself-without-rotation-in-pterygium-surgery-a-full-circle-in-conjunctival-autografting
#7
Shreesha Kumar Kodavoor, Nitin Narendra Tiwari, Dandapani Ramamurthy
Purpose: The aim of this study is to describe a modified technique of using conjunctival tissue from the pterygium itself without any rotation of graft for the primary pterygium in eyes with glaucoma filtering bleb, glaucoma suspects, and in primary double-head pterygium using fibrin glue. Methods: In this retrospective, noncomparative, interventional case series, 98 eyes of 98 patients with primary pterygium operated between July 2011 to July 2016 were included...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580976/inter-eye-asymmetry-of-optical-coherence-tomography-angiography-vessel-density-in-bilateral-glaucoma-glaucoma-suspect-and-healthy-eyes
#8
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. DESIGN: Cross-sectional study. METHODS: 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans...
March 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29571832/clinical-prediction-performance-of-glaucoma-progression-using-a-2-dimensional-continuous-time-hidden-markov-model-with-structural-and-functional-measurements
#9
Youngseok Song, Hiroshi Ishikawa, Mengfei Wu, Yu-Ying Liu, Katie A Lucy, Fabio Lavinsky, Mengling Liu, Gadi Wollstein, Joel S Schuman
PURPOSE: Previously, we introduced a state-based 2-dimensional continuous-time hidden Markov model (2D CT HMM) to model the pattern of detected glaucoma changes using structural and functional information simultaneously. The purpose of this study was to evaluate the detected glaucoma change prediction performance of the model in a real clinical setting using a retrospective longitudinal dataset. DESIGN: Longitudinal, retrospective study. PARTICIPANTS: One hundred thirty-four eyes from 134 participants diagnosed with glaucoma or as glaucoma suspects (average follow-up, 4...
March 20, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29550190/six-month-longitudinal-comparison-of-a-portable-tablet-perimeter-with-the-humphrey-field-analyser
#10
Selwyn Marc Prea, Yu Xiang George Kong, Aditi Mehta, Mingguang He, Jonathan G Crowston, Viney Gupta, Keith R Martin, Algis J Vingrys
PURPOSE: To establish the medium-term repeatability of the iPad perimetry app Melbourne Rapid Fields (MRF) compared to Humphrey Field Analyzer (HFA) 24-2 SITA-standard and SITA-fast programs. DESIGN: Multicentre longitudinal observational clinical study. PARTICIPANTS: 60 patients (stable glaucoma/ocular hypertension/glaucoma suspects) were recruited into a 6-month longitudinal clinical study with visits planned at baseline, 2-, 4- and 6-months...
March 14, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29516048/the-importance-of-ganglion-cell-complex-investigation-in-myopic-patients
#11
Maria Veronica Strehaianu, Dana Dascalescu, Catalina Ionescu, Miruna Burcel, Vasile Potop, Catalina Corbu
Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickness. However, due to disc tilting and peripapillary atrophy, the RNFL evaluation may be prone to errors in myopic patients...
October 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29506916/prevalence-of-primary-open-angle-glaucoma-among-patients-with-obstructive-sleep-apnea
#12
Arthur H Friedlander, Lindsay L Graves, Tina I Chang, K Karl Kawakami, Urie K Lee, Shannon C Grabich, Zhuang T Fang, Michelle R Zeidler, JoAnn A Giaconi
OBJECTIVE: Our objective was to determine primary open-angle glaucoma (POAG) prevalence among obstructive sleep apnea (OSA) patients because the perioperative environment risks further damaging the optic nerve. STUDY DESIGN: We analyzed a "convenience sample" referred by Sleep Medicine for oral appliances because of continuous positive airway pressure intolerance. We determined the aggregate prevalence of the 3 POAG subtypes-"classic" open-angle glaucoma (COAG), normal-tension glaucoma (NTG), and open-angle glaucoma suspect (OAGS)-among the index population and compared it with that of same hospital's general population...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29492992/glaucoma-referral-refinement-in-ireland-managing-the-sensitivity-specificity-paradox-in-optometric-practice
#13
Catriona Barrett, Colm O'Brien, James Loughman
PURPOSE: Glaucoma referral refinement (GRR) has proven a successful demand management strategy for glaucoma suspect cases in the United Kingdom (UK). A GRR clinic was established in Dublin, Ireland to investigate the clinical viability of this pathway outside the UK's National Health Service (NHS) structures, and away from the influence of National Institute for Clinical Excellence (NICE) guidance. METHODS: Glaucoma suspect patients were recruited into the scheme following referral from community optometrists in the greater Dublin area...
February 28, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29390457/diagnostic-ability-of-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma-suspects
#14
Xiaoyu Xu, Hui Xiao, Xinxing Guo, Xiangxi Chen, Linlin Hao, Jingyi Luo, Xing Liu
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell-inner plexiform layer (GCIPL) thickness in a Chinese population including glaucoma suspects.A total of 367 eyes with primary open-angle glaucoma (168 early glaucoma, 78 moderate glaucoma, and 121 advanced glaucoma), 52 eyes with ocular hypertension (OHT), 59 eyes with enlarged cup-to-disc ratio (C/D), and 225 normal eyes were included. GCIPL thickness (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal), retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters were measured using Cirrus high-definition optical coherence tomography (OCT) and compared...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29330448/visual-field-loss-and-vision-related-quality-of-life-in-the-italian-primary-open-angle-glaucoma-study
#15
Eliana Rulli, Luciano Quaranta, Ivano Riva, Davide Poli, Lital Hollander, Fabio Galli, Andreas Katsanos, Francesco Oddone, Valter Torri, Robert N Weinreb
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS)...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303870/the-association-between-macula-and-onh-optical-coherence-tomography-angiography-oct-a-vessel-densities-in-glaucoma-glaucoma-suspect-and-healthy-eyes
#16
Patricia I C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min H Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between optical coherence tomography (OCT)-angiography vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. MATERIALS AND METHODS: This cross-sectional study included 333 eyes of 219 primary open-angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) with good quality OCT angiography images...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29300714/electrophysiology-of-olfactory-and-optic-nerve-in-outpatient-and-intraoperative-settings
#17
Praveen Hariharan, Jeffery R Balzer, Katherine Anetakis, Donald J Crammond, Parthasarathy D Thirumala
Evoked potentials are time-locked electrophysiologic potentials recorded in response to standardized stimuli using scalp electrodes. These responses provide good temporal resolution and have been used in various clinical and intraoperative settings. Olfactory evoked potentials (OEPs) may be used as an adjunct tool in identifying patients of Parkinson disease and Alzheimer dementia. In clinical practice, visual evoked potentials (VEPs) are particularly useful in identifying subclinical cases of optic neuritis and in treatment surveillance...
January 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29151681/incidence-and-risk-factors-of-early-onset-glaucoma-following-pediatric-cataract-surgery-in-egyptian-children-one-year-study
#18
Ghada I Gawdat, Maha M Youssef, Nermeen M Bahgat, Dina M Elfayoumi, Mohamed As Eddin
Aim: To study the incidence and risk factors of glaucoma occurring within 1 year following pediatric cataract surgery in Egyptian children. Materials and methods: This is a prospective nonrandomized study conducted at Aburich Children's Hospital, over a period of 1 year on a cohort of Egyptian patients with congenital and infantile cataract. One hundred and fifty eyes of 88 patients were enrolled in this study. All the patients underwent anterior approach removal of lens matter, whereas primary intraocular lens (IOL) implantation was carried at the age of 1 and 2 years for unilateral and bilateral cases respectively...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29114838/optical-coherence-tomography-angiography-macular-and-peripapillary-vessel-perfusion-density-in-healthy-subjects-glaucoma-suspects-and-glaucoma-patients
#19
COMPARATIVE STUDY
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049726/comparison-of-sectoral-structure-function-relationships-in-glaucoma-vessel-density-versus-thickness-in-the-peripapillary-retinal-nerve-fiber-layer
#20
COMPARATIVE STUDY
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
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