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"Glaucoma suspect"

Maria Veronica Strehaianu, Dana Dascalescu, Catalina Ionescu, Miruna Burcel, Vasile Potop, Catalina Corbu
Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickness. However, due to disc tilting and peripapillary atrophy, the RNFL evaluation may be prone to errors in myopic patients...
October 2017: Romanian Journal of Ophthalmology
Arthur H Friedlander, Lindsay L Graves, Tina I Chang, K Karl Kawakami, Urie K Lee, Shannon C Grabich, Zhuang T Fang, Michelle R Zeidler, JoAnn A Giaconi
OBJECTIVE: Our objective was to determine primary open-angle glaucoma (POAG) prevalence among obstructive sleep apnea (OSA) patients because the perioperative environment risks further damaging the optic nerve. STUDY DESIGN: We analyzed a "convenience sample" referred by Sleep Medicine for oral appliances because of continuous positive airway pressure intolerance. We determined the aggregate prevalence of the 3 POAG subtypes-"classic" open-angle glaucoma (COAG), normal-tension glaucoma (NTG), and open-angle glaucoma suspect (OAGS)-among the index population and compared it with that of same hospital's general population...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Catriona Barrett, Colm O'Brien, James Loughman
PURPOSE: Glaucoma referral refinement (GRR) has proven a successful demand management strategy for glaucoma suspect cases in the United Kingdom (UK). A GRR clinic was established in Dublin, Ireland to investigate the clinical viability of this pathway outside the UK's National Health Service (NHS) structures, and away from the influence of National Institute for Clinical Excellence (NICE) guidance. METHODS: Glaucoma suspect patients were recruited into the scheme following referral from community optometrists in the greater Dublin area...
February 28, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Xiaoyu Xu, Hui Xiao, Xinxing Guo, Xiangxi Chen, Linlin Hao, Jingyi Luo, Xing Liu
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell-inner plexiform layer (GCIPL) thickness in a Chinese population including glaucoma suspects.A total of 367 eyes with primary open-angle glaucoma (168 early glaucoma, 78 moderate glaucoma, and 121 advanced glaucoma), 52 eyes with ocular hypertension (OHT), 59 eyes with enlarged cup-to-disc ratio (C/D), and 225 normal eyes were included. GCIPL thickness (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal), retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters were measured using Cirrus high-definition optical coherence tomography (OCT) and compared...
December 2017: Medicine (Baltimore)
Eliana Rulli, Luciano Quaranta, Ivano Riva, Davide Poli, Lital Hollander, Fabio Galli, Andreas Katsanos, Francesco Oddone, Valter Torri, Robert N Weinreb
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS)...
January 12, 2018: Scientific Reports
Patricia I C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min H Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between optical coherence tomography (OCT)-angiography vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. MATERIALS AND METHODS: This cross-sectional study included 333 eyes of 219 primary open-angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) with good quality OCT angiography images...
March 2018: Journal of Glaucoma
Praveen Hariharan, Jeffery R Balzer, Katherine Anetakis, Donald J Crammond, Parthasarathy D Thirumala
Evoked potentials are time-locked electrophysiologic potentials recorded in response to standardized stimuli using scalp electrodes. These responses provide good temporal resolution and have been used in various clinical and intraoperative settings. Olfactory evoked potentials (OEPs) may be used as an adjunct tool in identifying patients of Parkinson disease and Alzheimer dementia. In clinical practice, visual evoked potentials (VEPs) are particularly useful in identifying subclinical cases of optic neuritis and in treatment surveillance...
January 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Ghada I Gawdat, Maha M Youssef, Nermeen M Bahgat, Dina M Elfayoumi, Mohamed As Eddin
Aim: To study the incidence and risk factors of glaucoma occurring within 1 year following pediatric cataract surgery in Egyptian children. Materials and methods: This is a prospective nonrandomized study conducted at Aburich Children's Hospital, over a period of 1 year on a cohort of Egyptian patients with congenital and infantile cataract. One hundred and fifty eyes of 88 patients were enrolled in this study. All the patients underwent anterior approach removal of lens matter, whereas primary intraocular lens (IOL) implantation was carried at the age of 1 and 2 years for unilateral and bilateral cases respectively...
September 2017: Journal of Current Glaucoma Practice
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
Hassan Muhammad, Thomas J Fuchs, Nicole De Cuir, Carlos G De Moraes, Dana M Blumberg, Jeffrey M Liebmann, Robert Ritch, Donald C Hood
PURPOSE: Existing summary statistics based upon optical coherence tomographic (OCT) scans and/or visual fields (VFs) are suboptimal for distinguishing between healthy and glaucomatous eyes in the clinic. This study evaluates the extent to which a hybrid deep learning method (HDLM), combined with a single wide-field OCT protocol, can distinguish eyes previously classified as either healthy suspects or mild glaucoma. METHODS: In total, 102 eyes from 102 patients, with or suspected open-angle glaucoma, had previously been classified by 2 glaucoma experts as either glaucomatous (57 eyes) or healthy/suspects (45 eyes)...
December 2017: Journal of Glaucoma
V A Machekhin, O L Fabrikantov
AIM: To analyze anatomical and topographic optic disc parameters with account to the disc area in glaucoma suspects. MATERIAL AND METHODS: The study included 302 patients (408 eyes) aged 25 to 76 years (the mean age of 50.5±12.5 years); men and women roughly equal in number. The eyes were divided into 8 groups depending on the disc area, which ranged from 0.89 to 3.5 mm2. With HRT, 11 global and sector optic disc parameters were examined, 4 of which (disc area, rim area, cup/disc ratio, mean RNFL thickness) are presented in this paper...
2017: Vestnik Oftalmologii
Xinbo Zhang, Anna Dastiridou, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, David Huang
PURPOSE: To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). DESIGN: Validity assessment. METHODS: We analyzed subjects with more than 4 semi-annual follow-up visits (every 6 months) in the multicenter Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC)...
December 2017: American Journal of Ophthalmology
Jean-Claude Mwanza, Linda Y Huang, Donald L Budenz, Wei Shi, Gintien Huang, Richard K Lee
PURPOSE: To compare the vertical and horizontal cup-to-disc ratio (VCDR, HCDR) by an updated optical coherence tomography (OCT) Bruch membrane opening (BMO) algorithm and stereoscopic optic disc photograph readings by glaucoma specialists. DESIGN: Reliability analysis. METHODS: A total of 195 eyes (116 glaucoma and 79 glaucoma suspect) of 99 patients with stereoscopic photographs and OCT scans of the optic discs taken during the same visit were compared...
December 2017: American Journal of Ophthalmology
Matthew B Greenberg, Carla J Osigian, Kara M Cavuoto, Ta C Chang
PURPOSE: To investigate the outcomes of childhood glaucoma suspects. DESIGN: Retrospective case series. METHODS: Records of childhood glaucoma suspects were identified using financial claims data; medical history, baseline biometric and exam findings were recorded. Conversion from suspect to glaucoma was determined based on the Childhood Glaucoma Research Network criteria. The study adheres to the tenets of the Declarations of Helsinki. RESULTS: 214 subjects were enrolled, with median age at initial presentation of 6...
2017: PloS One
Natasha Gautam Seth, Sushmita Kaushik, Savleen Kaur, Srishti Raj, Surinder Singh Pandav
BACKGROUND: Assessment of spectral-domain optical coherence tomography (SD-OCT) compared with visual fields, to detect progression across the glaucoma spectrum. METHODS: In this study, adult glaucoma suspects and patients, with baseline retinal nerve fibre layer (RNFL) thickness on SD-OCT and reliable visual field (VF) tests on Humphrey Field Analyser (HFA) prior to March 2010, were recruited. Functional and structural progression over at least 5 years was compared using Glaucoma Progression Analysis (GPA) and VF index (VFI) on HFA and Guided Progression Analysis (GPA-OCT) on SD-OCT, respectively...
September 22, 2017: British Journal of Ophthalmology
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
Ji Woong Park, Bong Hui Kang, Ji Won Kwon, Kyong Jin Cho
BACKGROUND: Pupil size is an important factor in predicting post-operative satisfaction. We assessed the correlation between pupil size, measured by Humphrey static perimetry, and various affecting factors in patients with glaucoma. METHODS: In total, 825 eyes of 415 patients were evaluated retrospectively. Pupil size was measured with Humphrey static perimetry. Comparisons of pupil size according to the presence of glaucoma were evaluated, as were correlations between pupil size and various factors, including age, logMAR best corrected visual acuity (BCVA), retinal nerve fiber layer (RNFL) thickness, spherical equivalent, intraocular pressure, axial length, central corneal thickness, white-to-white, and the kappa angle...
September 16, 2017: BMC Ophthalmology
Michelle P Y Chan, David C Broadway, Anthony P Khawaja, Jennifer L Y Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.Design Community based cross sectional observational study.Setting EPIC-Norfolk cohort in Norwich and the surrounding rural and urban areas.Participants 8623 participants aged 48-92 recruited from the community who underwent ocular examination to identify glaucoma.Main outcome measures Prevalence and characteristics of glaucoma, distribution of IOP, and the sensitivity and specificity of IOP for case finding for glaucoma...
September 13, 2017: BMJ: British Medical Journal
Bo Wang, Katie A Lucy, Joel S Schuman, Hiroshi Ishikawa, Richard A Bilonick, Ian A Sigal, Larry Kagemann, Chen Lu, James G Fujimoto, Gadi Wollstein
Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT)...
August 30, 2017: Scientific Reports
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