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"Glaucoma suspect"

Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Siamak Yousefi, Luke J Saunders, Akram Belghith, Patricia Isabel C Manalastas, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 153 eyes from 31 healthy participants, 48 glaucoma suspects, and 74 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: All eyes underwent imaging using OCT-A (Angiovue; Optovue, Fremont, CA), spectral-domain OCT (Avanti; Optovue), and standard automated perimetry (SAP)...
October 7, 2016: Ophthalmology
Adel Galal Zaky, Ahmed Tarek Yassin, Saber Hamed El Sayid
OBJECTIVE: To assess the role and diagnostic effectiveness of optical coherence tomography (OCT) and short wave-automated perimetry (SWAP) to distinguish between normal, glaucoma suspects, and surely diagnosed glaucomatous eye. BACKGROUND: Changes in the optic disc and retinal nerve fiber layer (RNFL) often precede the appearance of visual field defect with standard automated perimetry. Unfortunately, RNFL defect can be difficult to identify during clinical examination...
2016: Clinical Ophthalmology
Sieun Lee, Nicolas Charon, Benjamin Charlier, Karteek Popuri, Evgeniy Lebed, Marinko V Sarunic, Alain Trouvé, Mirza Faisal Beg
We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be measured by the geometrical deformation and functional residual between the template and each of the observations...
September 20, 2016: Medical Image Analysis
Prakash Adhikari, Andrew J Zele, Ravi Thomas, Beatrix Feigl
It is difficult to detect visual function deficits in patients at risk for glaucoma (glaucoma suspects) and at early disease stages with conventional ophthalmic tests such as perimetry. To this end, we introduce a novel quadrant field measure of the melanopsin retinal ganglion cell mediated pupil light response corresponding with typical glaucomatous arcuate visual field defects. The melanopsin-mediated post-illumination pupil response (PIPR) was measured in 46 patients with different stages of glaucoma including glaucoma suspects and compared to a healthy group of 21 participants with no disease...
2016: Scientific Reports
Alberto Diniz-Filho, Ricardo Y Abe, Linda M Zangwill, Carolina P B Gracitelli, Robert N Weinreb, Christopher A Girkin, Jeffrey M Liebmann, Felipe A Medeiros
PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and rates of retinal nerve fiber layer (RNFL) thickness change over time measured by spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Observational cohort study. PARTICIPANTS: The study involved 547 eyes of 339 patients followed up for an average of 3.9±0.9 years. Three hundred eight (56.3%) had a diagnosis of glaucoma and 239 (43.7%) were considered glaucoma suspects...
October 2016: Ophthalmology
Asem Alqudah, Steven L Mansberger, Stuart K Gardiner, Shaban Demirel
PURPOSE: To determine the association of vision-related quality of life (QoL) to demographic factors and visual function in glaucoma suspect or early glaucoma patients. MATERIALS AND METHODS: We administered the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) on the same day as a comprehensive ocular examination to participants either with glaucoma or at high risk for developing glaucoma. Regression models were used to determine the association between VFQ-25 composite and subscale scores, visual field status, logMAR equivalent visual acuity (VA), age, and sex...
August 2016: Journal of Glaucoma
Nayuta Yoshioka, Elizabeth Wong, Michael Kalloniatis, Barbara Zangerl
BACKGROUND: The Heidelberg Retina Tomograph (HRT) is a commonly-used clinical instrument for glaucoma diagnosis; however, the repeatability of the two most commonly used analysis tools, Moorfield regression analysis (MRA) and 'glaucoma probability score' (GPS) is not known and could have significant implications for patients at risk or suspected of developing glaucoma. Thus, the intra-visit repeatability of the HRT3 (an objective measure of instrument-induced variability) was investigated in a glaucoma suspect cohort...
August 1, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Zaid Mammo, Morgan Heisler, Chandrakumar Balaratnasingam, Sieun Lee, Dao-Yi Yu, Paul Mackenzie, Steven Schendel, Andrew Merkur, Andrew Kirker, David Albiani, Eduardo Navajas, Mirza Faisal Beg, William Morgan, Marinko V Sarunic
PURPOSE: To evaluate the quantitative characteristics of the radial peripapillary capillary (RPC) network in glaucoma, glaucoma suspect, and normal eyes using speckle variance optical coherence tomography angiography (OCT-A). To determine correlations between RPC density, nerve fiber layer (NFL) thickness, and visual field indices. DESIGN: Cross-sectional study. METHODS: OCT-A images of RPCs were acquired at a single institution using a custom-built 1060 nm system from 3 groups: unilateral glaucoma (10 eyes from 5 subjects), glaucoma suspects (6 eyes from 3 subjects), and normal control eyes (16 eyes from 9 normal subjects)...
October 2016: American Journal of Ophthalmology
Chieh-Li Chen, Anqi Zhang, Karine D Bojikian, Joanne C Wen, Qinqin Zhang, Chen Xin, Raghu C Mudumbai, Murray A Johnstone, Philip P Chen, Ruikang K Wang
PURPOSE: To investigate the vascular microcirculation changes in the retinal nerve fiber layer (RNFL) in normal, glaucoma suspect, and open-angle glaucoma (OAG) groups using optical coherence tomography-based microangiography (OMAG). METHODS: One eye from each subject was scanned with a Cirrus HD-OCT 5000-based OMAG prototype system montage scanning protocol centered at the optic nerve head (ONH). Blood flow signals were extracted using OMAG algorithm. Retinal nerve fiber layer vascular microcirculation was measured by calculating the blood flux index and vessel area density within a 1...
July 1, 2016: Investigative Ophthalmology & Visual Science
Diego T Dias, Michele Ushida, Marina C Sousa, Syril Dorairaj, Luis G Biteli, Mauro T Leite, Augusto Paranhos, Tiago S Prata
Among all glaucoma suspects, eyes with optic nerve head features suspicious or suggestive of early glaucoma are probably those that offer the greatest challenge for clinicians. In contrast with the robust longitudinal data published on ocular hypertension, there is no specific management guideline for these patients. Therefore, evaluating eyes with suspicious optic disc appearance and normal intraocular pressure (IOP), we sought to investigate potential differences in clinical and epidemiological characteristics to differentiate those with normal-tension glaucoma (NTG) from those with presumed large physiological optic disc cups (pLPC)...
2016: PloS One
Lukas Reznicek, Daniel Muth, Michaela Vogel, Christoph Hirneiß
PURPOSE: To evaluate the relationship between functional parameters of repeated flicker-defined form perimetry (FDF) and structural parameters of spectral-domain optical coherence tomography (SD-OCT) in glaucoma suspects with normal findings in achromatic standard automated perimetry (SAP). METHODS: Patients with optic nerve heads (ONH) clinically suspicious for glaucoma and normal SAP findings were enrolled in this prospective study. Each participant underwent visual field (VF) testing with FDF perimetry, using the Heidelberg Edge Perimeter (HEP, Heidelberg Engineering, Heidelberg, Germany) at two consecutive visits...
July 15, 2016: Current Eye Research
Dana M Blumberg, Carlos Gustavo De Moraes, Jeffrey M Liebmann, Reena Garg, Cynthia Chen, Alex Theventhiran, Donald C Hood
PURPOSE: To determine and compare the diagnostic performance of spectral-domain optical coherence tomography (SD-OCT), stereoscopic disc photographs, and automated perimetry as assessed by a group of glaucoma specialists in differentiating individuals with early glaucoma from suspects. METHODS: Forty-six eyes (46 patients) with suspicious optic nerves had previously undergone SD-OCT scans, 24-2 visual fields (VFs), and optic disc photographs. The average VF mean deviation was -1...
July 1, 2016: Investigative Ophthalmology & Visual Science
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Patricia Isabel Manalastas, Naeem Fatehee, Siamak Yousefi, Akram Belghith, Luke J Saunders, Felipe A Medeiros, David Huang, Robert N Weinreb
PURPOSE: The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS: Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A images were included. Retinal vasculature information was summarized as a vessel density map and as vessel density (%), which is the proportion of flowing vessel area over the total area evaluated...
July 1, 2016: Investigative Ophthalmology & Visual Science
Bo Wang, Katie A Lucy, Joel S Schuman, Ian A Sigal, Richard A Bilonick, Larry Kagemann, Tigran Kostanyan, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, James G Fujimoto, Hiroshi Ishikawa, Gadi Wollstein
PURPOSE: To investigate how the lamina cribrosa (LC) microstructure changes with distance from the central retinal vessel trunk (CRVT), and to determine how this change differs in glaucoma. METHODS: One hundred nineteen eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) of 105 subjects were imaged using swept-source optical coherence tomography (OCT). The CRVT was manually delineated at the level of the anterior LC surface. A line was fit to the distribution of LC microstructural parameters and distance from CRVT to measure the gradient (change in LC microstructure per distance from the CRVT) and intercept (LC microstructure near the CRVT)...
June 1, 2016: Investigative Ophthalmology & Visual Science
Eunjoo Yoo, Chungkwon Yoo, Tae-Eun Lee, Yong Yeon Kim
PURPOSE: To investigate retinal vessel diameter in patients classified as bilateral glaucoma suspects who showed unilateral glaucomatous conversion. METHODS: This retrospective study included 21 patients who had initially been diagnosed as bilateral glaucoma suspects but showed unilateral glaucomatous conversion during a follow-up period of more than 2 years. Conversion to glaucoma was determined either by documentation of a new retinal nerve fiber layer defect on red-free photography or a reproducible glaucomatous visual field defect...
August 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Fabio N Kanadani, Tca Moreira, Bsp Bezerra, M P Vianello, J Corradi, S K Dorairaj, T S Prata
PURPOSE: To describe the diurnal variation of the ocular perfusion pressure (OPP) in normal, suspects and glaucoma patients. MATERIALS AND METHODS: Seventy-nine subjects were enrolled in a prospective study. The diurnal curve of intraocular pressure (IOP) was performed and blood pressure measurements were obtained. Each participant was grouped into one of the following based upon the clinical evaluation of the optic disk, IOP and standard achromatic perimetry (SAP): 18 eyes were classified as normal (normal SAP, normal optic disk evaluation and IOP < 21 mm Hg in two different measurements), 30 eyes as glaucoma suspect (GS) (normal SAP and mean deviation (MD), C/D ration > 0...
January 2016: Journal of Current Glaucoma Practice
Fabio N Kanadani, Tca Moreira, L F Campos, M P Vianello, J Corradi, S K Dorairaj, Ala Freitas, R Ritch
PURPOSE: To compare the effects of the water-drinking test (WDT) with the 30° inverted body position test on intraocular pressure (IOP) in normal patients, suspected glaucoma patients and glaucoma patients. MATERIALS AND METHODS: Based on clinical evaluation of the optic disk, IOP, and standard achromatic perimetry (SAP) of 71 eyes, 18 were "normal" (normal SAP and optic disk evaluation, and IOP < 21 mm Hg), 30 were "glaucoma suspect" (GS; normal SAP, cup/disk (C/D) ratio > 0...
January 2016: Journal of Current Glaucoma Practice
Jong Hoon Lim, Jun Sang Park, So Yeon Lee, Young Jae Hong
BACKGROUND: To investigate the incidence and risk factors of glaucoma in normal-tension glaucoma (NTG) suspect patients who had been lost-to-follow-up for at least 24 months. METHODS: Seventy-two eyes of 72 NTG suspect patients who returned to the hospital after at least 24 months of follow-up loss were enrolled in this study between January 2009 and June 2013. The data were collected retrospectively. The incidence of glaucoma was investigated using a comprehensive glaucoma evaluation in lost-to-follow-up NTG suspect patients...
2016: BMC Ophthalmology
Emmanuel Kwasi Abu, Samuel Bert Boadi-Kusi, Prince Quarcoo Opuni, Samuel Kyei, Andrew Owusu-Ansah, Charles Darko-Takyi
PURPOSE: To conduct an ocular health and safety assessment among mechanics in the Cape Coast Metropolis, Ghana. METHODS: This descriptive cross sectional study included 500 mechanics using multistage sampling. All participants filled a structured questionnaire on demographic data, occupational history and ocular health history. Study participants underwent determination of visual acuity (VA) using LogMAR chart, external eye examination with a handheld slit lamp biomicroscope, dilated fundus examination, applanation tonometry and refraction...
January 2016: Journal of Ophthalmic & Vision Research
Dina Tadros, Rupal H Trivedi, M Edward Wilson, Jennifer D Davidson
PURPOSE: To report the change in axial length (AL) over time and to compare the percentage of AL growth of pseudophakic eyes operated on for monocular cataract to that of the unoperated fellow eyes. METHODS: The medical records of children operated on by a single surgeon for monocular congenital cataract before 7 months of age were retrospectively reviewed. Inclusion criteria were corneal diameter of ≥9 mm and availability of AL data for >5 years' follow-up after cataract surgery and >1 year after IOL implantation (in case of secondary IOL)...
June 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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