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https://www.readbyqxmd.com/read/29160359/gastrointestinal-parasites-in-feral-cats-and-rodents-from-the-fernando-de-noronha-archipelago-brazil
#1
Victor Fernando Santana Lima, Rafael Antonio Nascimento Ramos, Raphael Lepold, João Carlos Gomes Borges, Carlos Diógenes Ferreira, Laura Rinaldi, Giuseppe Cringoli, Leucio Câmara Alves
Gastrointestinal parasites are important pathogens affecting animals, some of them are of medical and veterinary concern. Although the dynamic of parasitic infections is a complex phenomenon that has been studied under experimental conditions, it shows several gaps in knowledge, especially in insular regions where a confined population of animals and parasites co-exists. In this study was assessed the parasitism by endoparasite gastrointestinal in feral cats (n = 37) and rodents (n = 30) from the Fernando de Noronha Archipelago; in addition, the risk of human infection and ecological implications of these findings were discussed...
November 9, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29157507/public-attitudes-towards-involuntary-admission-and-treatment-by-mental-health-services-in-norway
#2
Inge Joa, Kjetil Hustoft, Liss Gøril Anda, Kolbjørn Brønnick, Olav Nielssen, Jan Olav Johannessen, Johannes H Langeveld
PURPOSE: The role of compulsory treatment of serious mental disorders has been the topic of ongoing public debate involving among others mental health professionals, service providers, service user advocates, relatives of service users, media commentators and politicians. However, relatively little is known about general public attitudes towards involuntary admission and compulsory treatment of people with various mental disorders. This article examines the attitudes in a representative sample of Norway's population towards the use of involuntary admission and treatment, and under which circumstances does the general public consider compulsory treatment to be justified in the Norwegian mental health care services...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29143662/heat-treatment-and-false-positive-heartworm-antigen-testing-in-ex-vivo-parasites-and-dogs-naturally-infected-by-dirofilaria-repens-and-angiostrongylus-vasorum
#3
Luigi Venco, Simone Manzocchi, Marco Genchi, Laura H Kramer
BACKGROUND: Heartworm antigen testing is considered sensitive and specific. Currently available tests are reported as detecting a glycoprotein found predominantly in the reproductive tract of the female worm and can reach specificity close to 100%. Main concerns regard sensitivity in the case of light infections, the presence of immature females or cases of all-male infections. Research and development have been aimed at increasing sensitivity. Recently, heat treatment of serum prior to antigen testing has been shown to result in an increase in positive antigen test results, presumably due to disruption of natural antigen-antibody complexes...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29140462/data-portal-for-the-library-of-integrated-network-based-cellular-signatures-lincs-program-integrated-access-to-diverse-large-scale-cellular-perturbation-response-data
#4
Amar Koleti, Raymond Terryn, Vasileios Stathias, Caty Chung, Daniel J Cooper, John P Turner, Dušica Vidovic, Michele Forlin, Tanya T Kelley, Alessandro D'Urso, Bryce K Allen, Denis Torre, Kathleen M Jagodnik, Lily Wang, Sherry L Jenkins, Christopher Mader, Wen Niu, Mehdi Fazel, Naim Mahi, Marcin Pilarczyk, Nicholas Clark, Behrouz Shamsaei, Jarek Meller, Juozas Vasiliauskas, John Reichard, Mario Medvedovic, Avi Ma'ayan, Ajay Pillai, Stephan C Schürer
The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analytics tools to improve our understanding of human diseases at the systems level. In contrast to other large-scale data generation efforts, LINCS Data and Signature Generation Centers (DSGCs) employ a wide range of assay technologies cataloging diverse cellular responses...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29126121/the-relationship-between-neighborhood-disorder-and-barriers-to-cessation-in-a-sample-of-impoverished-inner-city-smokers-in-baltimore-maryland-usa
#5
Carl Latkin, Ryan D Kennedy, Melissa Davey-Rothwell, Tuo-Yen Tseng, Lauren Czaplicki, Anirudh Baddela, Catie Edwards, Geetanjali Chander, Meghan Bridgid Moran, Amy Knowlton
Introduction: Economic disparities in rates of smoking have been well documented in many countries. These disparities exist on an individual and geographic or neighborhood level. This cross-sectional study examined the relationship between neighborhood physical and social disorder and barriers to smoking cessation among an impoverished urban sample. Methods: A sample of current smokers were recruited through street outreach, posted advertisements, and word of mouth from impoverished neighborhoods in Baltimore, Maryland, USA for a study of psychosocial factors and smoking behaviors...
November 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29122012/drug-target-ontology-to-classify-and-integrate-drug-discovery-data
#6
Yu Lin, Saurabh Mehta, Hande Küçük-McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J Yang, Cristian G Bologa, Tudor I Oprea, Stephan C Schürer
BACKGROUND: One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant research and development resources. The Illuminating the Druggable Genome (IDG) project develops resources to catalyze the development of likely targetable, yet currently understudied prospective drug targets. A central component of the IDG program is a comprehensive knowledge resource of the druggable genome...
November 9, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29114122/dot-enzyme-linked-immunosorbent-assay-elisa-for-the-detection-of-toxocara-infection-using-a-rat-model
#7
Vachel Gay V Paller, Cyrelle M Besana, Isabel Kristine M Valdez
Toxocariasis is a zoonotic disease usually caused by dog and cat roundworms, Toxocara canis and T. cati. Detection and diagnosis is difficult in paratenic and accidental hosts, including humans, as they cannot be detected through conventional methods such as fecal examination. Diagnosis therefore relies on immunological methods and molecular methods such as enzyme-linked immunosorbent assay (ELISA) and Western Blot, which are both time-consuming and requires sophisticated equipment. In the Philippines, only a few studies are available on Toxocara seroprevalence...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29111699/investigation-of-trimethyllysine-binding-by-the-hp1-chromodomain-via-unnatural-amino-acid-mutagenesis
#8
Stefanie A Baril, Amber L Koenig, Mackenzie W Krone, Katherine I Albanese, Cyndi Qixin He, Ga Young Lee, Kendall N Houk, Marcey L Waters, Eric M Brustad
Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating gene expression. Although all such reader proteins bind Kme3 in an aromatic cage, the driving force for binding may differ; some readers exhibit evidence for cation-π interactions whereas others do not. We report a general unnatural amino acid mutagenesis approach to quantify the contribution of individual tyrosines to cation binding using the HP1 chromodomain as a model system. We demonstrate that two tyrosines (Y24 and Y48) bind to a Kme3-histone tail peptide via cation-π interactions, but linear free energy trends suggest they do not contribute equally to binding...
November 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29084004/astigmatism-evaluation-prior-to-cataract-surgery
#9
Pankaj C Gupta, Jane T Caty
PURPOSE OF REVIEW: To evaluate and summarize literature from the past 18 months reporting advancements and issues in astigmatism assessment prior to cataract surgery. RECENT FINDINGS: New and updated toric calculators and regression formulas offer the opportunity for more accurate lens selection for our patients. Concurrently, improvements in topographic evaluation of corneal keratometry have allowed for a decrease in unplanned residual corneal astigmatism. Measuring posterior corneal astigmatism is especially valuable in eyes with keratoconus when planning to implant toric intraocular lens (IOL) and now allows access to this patient population...
October 27, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29069114/concomitant-calcium-channel-blocker-and-antipsychotic-therapy-in-patients-with-schizophrenia-efficacy-analysis-of-the-catie-sz-phase-1-data
#10
Priscilla Van Dyke, Kelan L Thomas
BACKGROUND: This study evaluated the influence of concomitant calcium channel blocker (CCB) and antipsychotic (AP) therapy on efficacy measures in patients with schizophrenia. METHODS: Data from the Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia study were used to evaluate the effect of concomitant CCB therapy on the Clinical Global Impression-Severity (CGI-S) score, Positive and Negative Syndrome Scale (PANSS) score, and time to all-cause discontinuation of AP treatment...
November 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29064910/a-molecular-pathway-analysis-informs-the-genetic-risk-for-arrhythmias-during-antipsychotic-treatment
#11
Ellen Kure Fischer, Antonio Drago
Arrhythmias are a frequent and potentially fatal side effect of antipsychotic treatment. Strict ECG monitoring and clinical interviews are the standards used to prevent arrhythmias. A biologic predictive tool is missing. The identification of a genetic makeup at risk of antipsychotic-induced arrhythmias is the aim of the present investigation. The aim of this study was to identify a molecular pathway enriched in single nucleotide polymorphisms associated with antipsychotic-induced QTc modifications. In total, 661 schizophrenic individuals from the CATIE study, M=486 (73...
October 23, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045769/placebo-effects-in-the-treatment-of-noncognitive-symptoms-of-alzheimer-s-disease-analysis-of-the-catie-ad-data
#12
Chisa Ozawa, Rachel Roberts, Kazunari Yoshida, Takefumi Suzuki, Barry Lebowitz, Suzanne Reeves, Robert Howard, Takayuki Abe, Masaru Mimura, Hiroyuki Uchida
OBJECTIVE: To compare symptom trajectories between placebo and active drug responders and to examine whether early placebo improvement would be associated with subsequent placebo response in the treatment of patients with behavioral and psychological symptoms of dementia. METHODS: A post hoc analysis of data from 371 patients with DSM-IV Alzheimer's disease in Phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness for Alzheimer's disease (CATIE-AD) (April 2001 to November 2004) was conducted...
October 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29034414/occurrence-and-zoonotic-potential-of-endoparasites-in-cats-of-cyprus-and-a-new-distribution-area-for-troglostrongylus-brevior
#13
Anastasia Diakou, Dimitra Sofroniou, Angela Di Cesare, Panagiotis Kokkinos, Donato Traversa
The present study investigated for the first time the occurrence of pulmonary and intestinal parasites of cats in Cyprus. Cats from five districts of Cyprus (Lefkosia, Lemesos, Larnaka, Pafos and Ammochostos) were examined by classical parasitological methods and the identity of lungworm larvae, whenever present, was confirmed by PCR-coupled sequencing. A total of 185 cats, 48 living exclusively indoors and 137 with outdoor access, were included in the study. Parasites were found in 66 (35.7%) of the examined cats, i...
December 2017: Parasitology Research
https://www.readbyqxmd.com/read/29033146/the-prevalence-and-performance-of-resistance-exercise-training-activities-in-an-australian-population-in-relation-to-health-authority-guidelines
#14
Brendan Humphries, Rob Stanton, Aaron Scanlan, Mitch J Duncan
OBJECTIVES: Resistance training research highlights the importance of training intensity to resistance exercise training (RET) and the associated benefits to health and function for healthy and at-risk populations. The American College of Sports Medicine (ACSM) recommend specific intensities, frequencies, repetitions, and number of exercises of RET to be performed to maintain health. The primary aim of this study was to describe the prevalence of achieving recommended levels of RET in relation to ACSM guidelines for intensity, frequency, repetitions, and number of exercises in a regional Australian population...
September 29, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29016316/toxocara-seroprevalence-and-associated-risk-factors-in-the-united-states
#15
Andrew N Berrett, Lance D Erickson, Shawn D Gale, Allison Stone, Bruce L Brown, Dawson W Hedges
Caused by the parasitic nematodes Toxocara canis and cati, toxocariasis in humans can result in covert toxocariasis, ocular toxocariasis, visceral larval migrans, and neurotoxocariasis. A common infection, toxocariasis exposure varies widely within and between countries, with a previous estimate of Toxocara seroprevalence using data from 1988 to 1994 in the United States of approximately 13%. Age, poverty, sex, educational attainment, ethnicity, and region have been associated with Toxocara seroprevalence. In this study, we sought to determine the seroprevalence of and factors associated with Toxocara seropositivity in the United States using data from the National Health and Nutrition Examination Survey from 2011 to 2014 to provide a more recent estimate of Toxocara seroprevalence in the United States...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991353/asymptomatic-leukemic-optic-nerve-infiltration-as-presentation-of-acute-lymphoblastic-leukemia-relapse
#16
Jane Caty, A Paula Grigorian, Florin Grigorian
The authors report a case of asymptomatic leukemic optic neuropathy as the first sign of acute lymphoblastic leukemia relapse in a 4-year-old boy. Routine ophthalmologic examination showed normal visual acuity and pupillary function in the presence of a tumoral mass covering the left optic disc. The mass resolved with preservation of vision after intrathecal chemotherapy. A routine ophthalmological examination is recommended for all patients with a history of acute lymphoblastic leukemia to exclude optic nerve involvement without systemic symptoms or signs...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28985928/methods-and-considerations-for-dynamic-analysis-of-functional-mr-imaging-data
#17
REVIEW
Jingyuan E Chen, Mikail Rubinov, Catie Chang
Functional MR imaging (fMR imaging) studies have recently begun to examine spontaneous changes in interregional interactions (functional connectivity) over seconds to minutes, and their relation to natural shifts in cognitive and physiologic states. This practice opens the potential for uncovering structured, transient configurations of coordinated brain activity whose features may provide novel cognitive and clinical biomarkers. However, analysis of these time-varying phenomena requires careful differentiation between neural and nonneural contributions to the fMR imaging signal and thorough validation and statistical testing...
November 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28975759/acute-kidney-injury-in-paediatric-diabetic-ketoacidosis-a-missed-opportunity
#18
Tristan W Harding, Catie A Fleming
No abstract text is available yet for this article.
October 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28953181/commentary-on-interventions-for-gait-training-in-children-with-spinal-cord-impairments-a-scoping-review
#19
Catie Christensen, Lori Fickes
No abstract text is available yet for this article.
October 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28951382/comparison-of-self-reported-telephone-interviewing-and-web-based-survey-responses-findings-from-the-second-australian-young-and-well-national-survey
#20
Alyssa C Milton, Louise A Ellis, Tracey A Davenport, Jane M Burns, Ian B Hickie
BACKGROUND: Web-based self-report surveying has increased in popularity, as it can rapidly yield large samples at a low cost. Despite this increase in popularity, in the area of youth mental health, there is a distinct lack of research comparing the results of Web-based self-report surveys with the more traditional and widely accepted computer-assisted telephone interviewing (CATI). OBJECTIVE: The Second Australian Young and Well National Survey 2014 sought to compare differences in respondent response patterns using matched items on CATI versus a Web-based self-report survey...
September 26, 2017: JMIR Mental Health
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