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https://www.readbyqxmd.com/read/28424579/grp78-at-the-centre-of-the-stage-in-cancer-and-neuroprotection
#1
REVIEW
Caty Casas
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. Most of these newly discovered activities depend on its position within the cell. GRP78 is located mainly in the ER, but it has also been observed in the cytoplasm, the mitochondria, the nucleus, the plasma membrane, and secreted, although it is dedicated mostly to engage endogenous cytoprotective processes...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28424002/enzyme-linked-immunosorbent-assays-for-coproantigen-detection-of-ancylostoma-caninum-and-toxocara-canis-in-dogs-and-toxocara-cati-in-cats
#2
David A Elsemore, Jinming Geng, Jennifer Cote, Rita Hanna, Araceli Lucio-Forster, Dwight D Bowman
We report the development and field validation of 2 ELISAs for the detection of Ancylostoma caninum or Toxocara canis coproantigens in the feces of dogs with experimental and natural infections, and evidence of cross-reactivity with respective feline counterparts. A. caninum-specific coproantigens were detected in feces of experimentally infected dogs starting at 9 d post-infection (dpi), whereas eggs were not seen until 23 dpi. T. canis-specific coproantigens were detected in 3 of 5 experimentally infected dogs by 31 dpi, and 4 of the 5 animals by 38 dpi...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28411264/grecos-project-genotyping-recurrence-risk-of-stroke-the-use-of-genetics-to-predict-the-vascular-recurrence-after-stroke
#3
Israel Fernández-Cadenas, Maite Mendióroz, Dolors Giralt, Cristina Nafria, Elena Garcia, Caty Carrera, Cristina Gallego-Fabrega, Sophie Domingues-Montanari, Pilar Delgado, Marc Ribó, Mar Castellanos, Sergi Martínez, Marimar Freijo, Jordi Jiménez-Conde, Marta Rubiera, José Alvarez-Sabín, Carlos A Molina, Maria Angels Font, Marta Grau Olivares, Ernest Palomeras, Natalia Perez de la Ossa, Maite Martinez-Zabaleta, Jaime Masjuan, Francisco Moniche, David Canovas, Carlos Piñana, Francisco Purroy, Dolores Cocho, Inma Navas, Carlos Tejero, Nuria Aymerich, Natalia Cullell, Elena Muiño, Joaquín Serena, Francisco Rubio, Antoni Davalos, Jaume Roquer, Juan Francisco Arenillas, Joan Martí-Fábregas, Keith Keene, Wei-Min Chen, Bradford Worrall, Michele Sale, Adrià Arboix, Jerzy Krupinski, Joan Montaner
BACKGROUND AND PURPOSE: Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS: We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients...
April 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28395755/efficacy-of-a-new-spot-on-formulation-of-selamectin-plus-sarolaner-against-ancylostoma-tubaeforme-and-toxocara-cati-in-cats
#4
Thomas Geurden, Adriano F Vatta, Nathalie Slootmans, Vickie L King, Dan Lin, Tom McTier, Douglas Rugg
The efficacy of a new spot-on formulation of selamectin plus sarolaner for cats was evaluated against induced infections with Ancylostoma tubaeforme (hookworm) and Toxocara cati (roundworm). Five laboratory studies were conducted using adult, purpose-bred cats. Four of the studies were designed to evaluate efficacy of the combination against A. tubaeforme, the dose-limiting gastrointestinal nematode species for selamectin. In two of these studies non-interference between selamectin and sarolaner was also evaluated...
April 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28350773/validity-of-an-accelerometer-used-to-measure-step-count-in-children-with-idiopathic-toe-walking
#5
Catie Christensen, Amanda Haddad, Elizabeth Maus
PURPOSE: To assess the validity of accelerometer use in children with idiopathic toe walking (ITW). METHODS: Seventy-five children, 2 to 13 years old, with ITW were videotaped ambulating 50 ft wearing a NL-1000 accelerometer. Because of concerns for accelerometer accuracy in young children, 2 groups were created: 5 years or younger (n = 45) and 6 years or older (n = 30). Step counts recorded via accelerometer and video were compared and correlated. RESULTS: There was a significant difference in accelerometer and video step counts for 2- to 5-year-olds (W = 72...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28339105/influence-of-extrusion-cooking-on-in-vitro-digestibility-physical-and-sensory-properties-of-brazilian-pine-seeds-flour-araucaria-angustifolia
#6
Manoela Estefânea Boff Zortéa-Guidolin, Carlos Wanderlei Piler de Carvalho, Rossana Catie Bueno de Godoy, Ivo Mottin Demiate, Agnes Paula Scheer
Brazilian pine seeds (pinhão) are gluten-free products derived from Araucaria angustifolia. The commercialization of these seeds is essentially associated with a low level of industrialization. In this context, extrusion cooking is a potential alternative for preparing extrudates of pinhão as a food product, which can be easily digested and is ready for human consumption. Brazilian pine seeds flour was processed in a single-screw extruder following a central composite rotatable design. Three factors (independent parameters) were considered: moisture content (14 to 22 g/100 g), screw speed (100 to 250 rpm), and temperature in the 3rd heating zone (120 to 200 °C)...
April 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28330485/prevalence-of-helminth-and-coccidian-parasites-in-swedish-outdoor-cats-and-the-first-report-of-aelurostrongylus-abstrusus-in-sweden-a-coprological-investigation
#7
Giulio Grandi, Arianna Comin, Osama Ibrahim, Roland Schaper, Ulrika Forshell, Eva Osterman Lind
BACKGROUND: This study was performed in order to gather recent epidemiological data on feline endoparasites in Swedish cats. Faecal samples from 205 outdoor cats were collected by their owners and submitted to the National Veterinary Institute for analysis. The study population was comprised of cats with access to an outdoor environment and with no history of anthelmintic treatment within the last 3 months. Intestinal parasites were detected with a centrifugal flotation technique and Baermann larval sedimentation was performed to detect metastrongylid lungworms...
March 23, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28288826/evaluation-of-acute-and-subacute-toxicity-of-hydroethanolic-extract-of-dolichandra-unguis-cati-l-leaves-in-rats
#8
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana Silva, Maria Izabel Ugalde Marques da Rocha, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant...
March 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28285023/consistency-checks-to-improve-measurement-with-the-positive-and-negative-syndrome-scale-panss
#9
Jonathan Rabinowitz, Nina R Schooler, Ariana Anderson, Lindsay Ayearst, David Daniel, Michael Davidson, Anzalee Khan, Bruce Kinon, Francois Menard, Lewis Opler, Mark Opler, Joanne B Severe, David Williamson, Christian Yavorsky, Jun Zhao
International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two...
March 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28278269/small-rodents-as-paratenic-or-intermediate-hosts-of-carnivore-parasites-in-berlin-germany
#10
Jürgen Krücken, Julia Blümke, Denny Maaz, Janina Demeler, Sabrina Ramünke, Daniela Antolová, Roland Schaper, Georg von Samson-Himmelstjerna
Rodents are important intermediate and paratenic hosts for carnivore parasites, including the important zoonotic agents Toxoplasma, Echinococcus and Toxocara. Monitoring of such parasites in rodents can be used to detect increasing risks for human and veterinary public health. Rodents were trapped at four sites in Berlin, two near the city center, two at the periphery. PCRs were conducted to detect Coccidia (target ITS-1) and specifically Toxoplasma gondii (repetitive element) in brain and ascarids (ITS-2) in muscle or brain tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28270139/psychosocial-determinants-of-hiv-testing-across-stages-of-change-in-spanish-population-a-cross-sectional-national-survey
#11
Maria Jose Fuster-RuizdeApodaca, Ana Laguia, Fernando Molero, Javier Toledo, Arantxa Arrillaga, Angeles Jaen
BACKGROUND: The goal of this research is to study the psychosocial determinants of HIV-testing as a function of the decision or change stage concerning this health behavior. The determinants considered in the major ongoing health models and the stages contemplated in the Precaution Adoption Process Model are analysed. METHODS: A cross-sectional survey was administered to 1,554 people over 16 years of age living in Spain by a computer-assisted telephone interview (CATI)...
March 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28217363/crystal-structures-of-n-2-n-3-n-5-n-6-tetra-kis-pyridin-2-ylmeth-yl-pyrazine-2-3-5-6-tetra-carboxamide-and-n-2-n-3-n-5-n-6-tetra-kis-pyridin-4-ylmeth-yl-pyrazine-2-3-5-6-tetra-carboxamide
#12
Dilovan S Cati, Helen Stoeckli-Evans
The title compounds, C32H28N10O4· unknown solvent, (I), and C32H28N10O4, (II), are pyrazine-2,3,5,6-tetra-carboxamide derivatives. In (I), the substituents are (pyridin-2-ylmeth-yl)carboxamide, while in (II), the substituents are (pyridin-4-ylmeth-yl)carboxamide. Both compounds crystallize in the monoclinic space group P21/n, with Z' = 1 for (I), and Z' = 0.5 for (II). The whole mol-ecule of (II) is generated by inversion symmetry, the pyrazine ring being situated about a center of inversion. In (I), the four pyridine rings are inclined to the pyrazine ring by 83...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28215900/lack-of-early-improvement-with-antipsychotics-is-a-marker-for-subsequent-nonresponse-in-behavioral-and-psychological-symptoms-of-dementia-analysis-of-catie-ad-data
#13
Kazunari Yoshida, Rachel Roberts, Takefumi Suzuki, Barry Lebowitz, Suzanne Reeves, Robert Howard, Takayuki Abe, Masaru Mimura, Hiroyuki Uchida
OBJECTIVE: Prediction of response or nonresponse to antipsychotics is especially important in patients with behavioral and psychological symptoms of dementia (BPSD) in whom antipsychotic exposure increases risks of death. This study examined whether the presence or absence of early improvement of BPSD with antipsychotics is associated with subsequent response or nonresponse. METHODS: In a post-hoc analysis of the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) study (2001-2004) (clinicaltrials...
January 30, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28215872/detection-of-specific-antibodies-in-cats-infected-with-the-lung-nematode-aelurostrongylus-abstrusus
#14
Eva-Maria Zottler, Christina Strube, Manuela Schnyder
Feline aelurostrongylosis, caused by the metastrongylid nematode Aelurostrongylus abstrusus, is an underestimated respiratory parasitosis. Its diagnosis currently mainly relies on the isolation of first stage larvae from fresh faecal samples. The aim of our study was to develop a serological test for the detection of specific antibodies against A. abstrusus by ELISA. We used recombinant major sperm protein (MSP) of the bovine lungworm Dictyocaulus viviparus as detection antigen and evaluated two different ELISA plates (Maxisorp and Immobilizer™ Amino-plate, Nunc Roskilde, Denmark) with two different enzyme systems [alkaline phosphatase (AP) and horseradish peroxidase (HRP)]...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28212400/surveys-of-public-knowledge-and-attitudes-with-regard-to-antibiotics-in-poland-did-the-european-antibiotic-awareness-day-campaigns-change-attitudes
#15
Beata Mazińska, Izabela Strużycka, Waleria Hryniewicz
BACKGROUND: Antimicrobial resistance is a global public health problem. Monitoring the level of knowledge regarding antibiotics is a part of the European Union Community strategy against antimicrobial resistance. OBJECTIVE: To assess knowledge by the general public in Poland regarding antibiotics, AMR, and the impact of the European Antibiotic Awareness Day campaigns. METHODS: The repeated cross-sectional study was developed and carried out among the general public in Poland (in 5 waves between 2009 and 2011, embracing a total of 5004 respondents)...
2017: PloS One
https://www.readbyqxmd.com/read/28179217/latino-adults-perspectives-on-treating-tobacco-use-via-social-media
#16
Beatriz Anguiano, Cati Brown-Johnson, Lisa G Rosas, Cornelia Pechmann, Judith J Prochaska
BACKGROUND: Latinos are the largest minority group in the United States, and in California they outnumber non-Hispanic whites. Smoking cessation programs tailored for Latino culture, and this population's specific smoking patterns, are needed. Online social networks for smoking cessation have high potential for Latinos, but have not been tested to date. OBJECTIVE: Building a research program on social media apps for cancer prevention in diverse populations, this qualitative study assessed acceptability of tobacco treatment that was distributed via social media for Latino smokers...
February 8, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28169880/blood-pressure-reduction-in-acute-ischemic-stroke-according-to-time-to-treatment-a-subgroup-analysis-of-the-china-antihypertensive-trial-in-acute-ischemic-stroke-trial
#17
Tan Xu, Yonghong Zhang, Xiaoqing Bu, Dali Wang, Yingxian Sun, Chung-Shiuan Chen, Jinchao Wang, Hao Peng, Zhong Ju, Yanbo Peng, Tian Xu, Qunwei Li, Deqin Geng, Jintao Zhang, Dong Li, Fengshan Zhang, Libing Guo, Xuemei Wang, Yong Cui, Yongqiu Li, Dihui Ma, Dongsheng Zhang, Guang Yang, Yanjun Gao, Xiaodong Yuan, Jing Chen, Jiang He
OBJECTIVE: The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS: We randomly assigned 4071 acute ischemic stroke patients with elevated SBP to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157623/toxocariasis-of-the-central-nervous-system-with-report-of-two-cases
#18
Bouthouri Abir, Mansour Malek, Mrissa Ridha
Toxocariasis is a parasitic infection caused by the roundworms Toxocara canis or Toxocara cati, mostly due to accidental ingestion of embryonated eggs. Clinical manifestations vary and are classified according to the organs affected. Central nervous system involvement is an unusual complication. Here, we report two cases with neurological manifestations, in which there was cerebrospinal fluid (CSF) eosinophilia with marked blood eosinophilia and a positive serology for Toxocara both in serum and CSF. Improvement of signs and symptoms after specific treatment was observed in the two cases...
March 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28150892/dissociated-patterns-of-anti-correlations-with-dorsal-and-ventral-default-mode-networks-at-rest
#19
Jingyuan E Chen, Gary H Glover, Michael D Greicius, Catie Chang
Previous studies of resting state functional connectivity have demonstrated that the default-mode network (DMN) is negatively correlated with a set of brain regions commonly activated during goal-directed tasks. However, the location and extent of anti-correlations are inconsistent across different studies, which has been posited to result largely from differences in whether or not global signal regression (GSR) was applied as a pre-processing step. Notably, coordinates of seed regions-of-interest defined within the posterior cingulate cortex (PCC)/precuneus, an area often employed to study functional connectivity of the DMN, have been inconsistent across studies...
May 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28141958/genetic-analysis-of-toxocara-cati-nematoda-ascarididae-from-guangdong-province-subtropical-china
#20
Xi He, Meng-Na Lv, Guo-Hua Liu, Rui-Qing Lin
Toxocara cati (cat roundworm) is a common parasitic nematode that infects humans and other hosts, causing toxocariasis. Although its significance as a pathogen, the epidemiology, genetics and biology of T. cati remain poorly understand in China. In the present study, genetic variation in mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) gene and internal transcribed spacer (ITS) of rDNA region among T. cati in Guangdong province, subtropical China was examined. A portion of the cox1 (pcox1) and the complete ITS (ITS1 + 5...
January 31, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
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