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resting-state functional magnetic resonance imaging

Chuanjun Zhuo, Jiajia Zhu, Chunli Wang, Hongru Qu, Xiaolei Ma, Wen Qin
Alterations in grey matter structure and functional connectivity (FC) are pathological features of major depressive disorder (MDD). However, the relationship between brain structural and functional impairments in MDD remains uncertain. Thus, the aim of this study was to investigate the relationship between alterations in grey matter volume (GMV) and resting-state global functional connectivity density (rs-gFCD) in MDD. Forty-five patients with MDD and 48 healthy controls underwent structural and resting-state functional magnetic resonance imaging (fMRI)...
October 20, 2016: Brain Imaging and Behavior
Yajing Pang, Qian Cui, Yifeng Wang, Yuyan Chen, Xiaona Wang, Shaoqiang Han, Zhiqiang Zhang, Guangming Lu, Huafu Chen
The amygdala plays a key role in emotion processing. Its functional connectivity with other brain regions has been extensively demonstrated to be associated with extraversion and neuroticism. However, how the amygdala affects other regions and is affected by others within these connectivity patterns associated with extraversion and neuroticism remains unclear. To address this issue, we investigated the effective connectivity of the amygdala using Granger causality analysis on the resting-state functional magnetic resonance imaging data of 70 participants...
October 21, 2016: Scientific Reports
Tina Gupta, Steven M Silverstein, Jessica A Bernard, Brian P Keane, Thomas V Papathomas, Andrea Pelletier-Baldelli, Derek J Dean, Raeana E Newberry, Ivanka Ristanovic, Vijay A Mittal
Patients with psychosis exhibit a reduced susceptibility to depth inversion illusions (DII) in which a physically concave surface is perceived as convex (e.g., the hollow mask illusion). Here, we examined the extent to which lessened susceptibility to DII characterized youth at ultra high risk (UHR) for psychosis. In this study, 44 UHR participants and 29 healthy controls judged the apparent convexity of face-like human masks, two of which were concave and the other convex. One of the concave masks was painted with realistic texture to enhance the illusion; the other was shown without such texture...
2016: NeuroImage: Clinical
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy)...
October 18, 2016: Brain Imaging and Behavior
R A Bryant, K L Felmingham, B Liddell, P Das, G S Malhi
The FKBP5 polymorphism is a key regulator of the glucocorticoid system underpinning stress responsivity, and risk alleles can increase vulnerability for developing posttraumatic stress disorder. To delineate the specific role of FKBP5 risk alleles unencumbered by the confounds of psychopathology, this study investigated whether high-risk alleles of the FKBP5 polymorphism are characterized by distinctive neural activity during resting state. Thirty-seven healthy participants were selected on the basis of four SNPs in the FKBP5 gene region (rs3800373, rs9296158, rs1360780 and rs9470080) to determine participants who were carriers of the FKBP5 high- and low-risk alleles...
October 18, 2016: Translational Psychiatry
Xu Lang, Le Wang, Chuan-Jun Zhuo, Feng Jia, Li-Na Wang, Chun-Li Wang
BACKGROUND: Previous studies have demonstrated interhemispheric functional connectivity alterations in schizophrenia. However, the relationship between these alterations and the disease state of schizophrenia is largely unknown. Therefore, we aimed to investigate this relationship using voxel-mirrored homotopic connectivity (VMHC) method. METHODS: This study enrolled 36 schizophrenia patients with complete remission, 58 schizophrenia patients with incomplete remission and 55 healthy controls...
2016: Chinese Medical Journal
Asanori Kiyuna, Norimoto Kise, Munehisa Hiratsuka, Shunsuke Kondo, Takayuki Uehara, Hiroyuki Maeda, Akira Ganaha, Mikio Suzuki
OBJECTIVES: Spasmodic dysphonia (SD) is considered a focal dystonia. However, the detailed pathophysiology of SD remains unclear, despite the detection of abnormal activity in several brain regions. The aim of this study was to clarify the pathophysiological background of SD. STUDY DESIGN: This is a case-control study. METHODS: Both task-related brain activity measured by functional magnetic resonance imaging by reading the five-digit numbers and resting-state functional connectivity (FC) measured by 150 T2-weighted echo planar images acquired without any task were investigated in 12 patients with adductor SD and in 16 healthy controls...
October 13, 2016: Journal of Voice: Official Journal of the Voice Foundation
Marloes A M Janssen, Max Hinne, Ronald J Janssen, Marcel A van Gerven, Stefan C Steens, Bozena Góraj, Peter P Koopmans, Roy P C Kessels
Despite long-term successful treatment with cART, impairments in cognitive functioning are still being reported in HIV-infected patients. Since changes in cognitive function may be preceded by subtle changes in brain function, neuroimaging techniques, such as resting-state functional magnetic resonance imaging (rs-fMRI) have become useful tools in assessing HIV-associated abnormalities in the brain. The purpose of the current study was to examine the extent to which HIV infection in virologically suppressed patients is associated with disruptions in subcortical regions of the brain in comparison to a matched HIV-negative control group...
October 15, 2016: Brain Imaging and Behavior
Karen Hodgson, Russell A Poldrack, Joanne E Curran, Emma E Knowles, Samuel Mathias, Harald Hh Göring, Nailin Yao, Rene L Olvera, Peter T Fox, Laura Almasy, Ravi Duggirala, Deanna M Barch, John Blangero, David C Glahn
Head movements are typically viewed as a nuisance to functional magnetic resonance imaging (fMRI) analysis, and are particularly problematic for resting state fMRI. However, there is growing evidence that head motion is a behavioral trait with neural and genetic underpinnings. Using data from a large randomly ascertained extended pedigree sample of Mexican Americans (n = 689), we modeled the genetic structure of head motion during resting state fMRI and its relation to 48 other demographic and behavioral phenotypes...
October 15, 2016: Cerebral Cortex
Jéssica Elias Vicentini, Marina Weiler, Sara Regina Meira Almeida, Brunno Machado de Campos, Lenise Valler, Li Min Li
Depression and anxiety symptoms are common after stroke and associated to reduction in quality of life and poor physical and social outcomes. The Default Mode Network (DMN) plays an important role in the emotional processing. We investigated whether these symptoms are associated to a disruption of DMN functional connectivity in the first month after stroke. Thirty-four subacute ischemic stroke patients were submitted to: 1) behavioral assessment through Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Structured Clinical Interview for DSM Disorders; 2) neuropsychological assessment using Mini Mental State Examination and Montreal Cognitive Assessment; 3) resting state functional magnetic resonance imaging acquisition using a 3 T scanner (Philips Achieva)...
October 14, 2016: Brain Imaging and Behavior
F Thomas, V Moulier, A Valéro-Cabré, D Januel
Auditory verbal hallucinations (AVH) are among the most characteristic symptoms of schizophrenia and have been linked to likely disturbances of structural and functional connectivity within frontal, temporal, parietal and subcortical networks involved in language and auditory functions. Resting-state functional magnetic resonance imaging (fMRI) has shown that alterations in the functional connectivity activity of the default-mode network (DMN) may also subtend hallucinations. Noninvasive neurostimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) have the ability to modulate activity of targeted cortical sites and their associated networks, showing a high potential for modulating altered connectivity subtending schizophrenia...
October 11, 2016: Revue Neurologique
Kristoffer H Madsen, Nathan W Churchill, Morten Mørup
Functional magnetic resonance imaging (fMRI) is increasingly used to characterize functional connectivity between brain regions. Given the vast number of between-voxel interactions in high-dimensional fMRI data, it is an ongoing challenge to detect stable and generalizable functional connectivity in the brain among groups of subjects. Component models can be used to define subspace representations of functional connectivity that are more interpretable. It is, however, unclear which component model provides the optimal representation of functional networks for multi-subject fMRI datasets...
October 14, 2016: Human Brain Mapping
Merve Cikili Uytun, Emel Karakaya, Didem Behice Oztop, Serife Gengec, Kazım Gumus, Sevgi Ozmen, Selim Doğanay, Semra Icer, Esra Demirci, Saliha Demirel Ozsoy
It is known that patients with Attention Deficit and Hyperactivity disorder (ADHD) and Conduct disorder (CD) commonly shows greater symptom severity than those with ADHD alone and worse outcomes. This study researches whether Default mode network (DMN) is altered in adolescents with ADHD + CD, relative to ADHD alone and controls or not. Ten medication-naïve boys with ADHD + CD, ten medication-naïve boys with ADHD and 10-age-matched typically developing (TD) controls underwent functional magnetic resonance imaging (fMRI) scans in the resting state and neuropsychological tasks such as the Wisconsin Card Sorting Test (WCST), Stroop Test TBAG Form (STP), Auditory Verbal learning Test (AVLT), Visual Auditory Digit Span B (VADS B) were applied to all the subjects included...
October 13, 2016: Brain Imaging and Behavior
Dennis van der Meer, Catharina A Hartman, Raimon H R Pruim, Maarten Mennes, Dirk Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Barbara Franke, Jan K Buitelaar, Pieter J Hoekstra
We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is increasingly recognized to be a key factor in ADHD-related impairment. The executive control and default mode brain networks play an important role in the regulation of emotion processing, and altered connectivity of these networks has also been associated with ADHD...
October 13, 2016: Brain Imaging and Behavior
Peng Liu, Yanfei Liu, Geliang Wang, Xuejuan Yang, Lingmin Jin, Jinbo Sun, Wei Qin
Primary dysmenorrhea (PDM), characterized by cramping pain in the lower abdomen, is a common gynecological disorder in women of child-bearing age. An increasing number of neuroimaging studies have emphasized that PDM is associated with functional and structural abnormalities in the regions related to the default mode network (DMN). Based on resting-state functional magnetic resonance imaging (fMRI), the aim of this study was to use amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) to investigate changes of the intrinsic brain activity in the DMN in PDM...
October 13, 2016: Brain Imaging and Behavior
Judy A Kipping, Ta Ahn Tuan, Marielle V Fortier, Anqi Qiu
Evidence from clinical studies shows that early cerebellar injury can cause abnormal development of the cerebral cortex in children. Characterization of normative development of the cerebellar and cerebello-cortical organization in early life is of great clinical importance. Here, we analyzed cerebellar, cerebello-cortical, and cortico-cortical functional networks using resting-state functional magnetic resonance imaging data of healthy infants (6 months, n = 21), children (4-10 years, n = 68), and adults (23-38 years, n = 25)...
October 12, 2016: Cerebral Cortex
Daihong Liu, Shanshan Duan, Jiuquan Zhang, Chaoyang Zhou, Minglong Liang, Xuntao Yin, Ping Wei, Jian Wang
Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment. However, its neurological mechanism remains elusive. Combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, the present study aimed to investigate brain functional alterations in middle-aged T2DM patients, which could provide complementary information for the neural substrates underlying T2DM-associated brain dysfunction. Twenty-five T2DM patients and 25 healthy controls were involved in neuropsychological testing and structural and resting-state functional magnetic resonance imaging (rs-fMRI) data acquisition...
2016: Frontiers in Human Neuroscience
Svyatoslav Vergun, Wolfgang Gaggl, Veena A Nair, Joshua I Suhonen, Rasmus M Birn, Azam S Ahmed, M Elizabeth Meyerand, James Reuss, Edgar A DeYoe, Vivek Prabhakaran
Functional magnetic resonance imaging studies have significantly expanded the field's understanding of functional brain activity of healthy and patient populations. Resting state (rs-) fMRI, which does not require subjects to perform a task, eliminating confounds of task difficulty, allows examination of neural activity and offers valuable functional mapping information. The purpose of this work was to develop an automatic resting state network (RSN) labeling method which offers value in clinical workflow during rs-fMRI mapping by organizing and quickly labeling spatial maps into functional networks...
2016: Frontiers in Neuroscience
Mona Maneshi, Shahabeddin Vahdat, Jean Gotman, Christophe Grova
Independent component analysis (ICA) has been widely used to study functional magnetic resonance imaging (fMRI) connectivity. However, the application of ICA in multi-group designs is not straightforward. We have recently developed a new method named "shared and specific independent component analysis" (SSICA) to perform between-group comparisons in the ICA framework. SSICA is sensitive to extract those components which represent a significant difference in functional connectivity between groups or conditions, i...
2016: Frontiers in Neuroscience
Santino Gaudio, Lyle Wiemerslage, Samantha J Brooks, Helgi B Schiöth
This paper systematically reviews the literature pertaining to the use of resting-state functional magnetic resonance imaging (rsfMRI) in anorexia nervosa (AN), classifying studies on the basis of different analysis approaches. We followed PRISMA guidelines. Fifteen papers were included, investigating a total of 294 participants with current or past AN and 285 controls. The studies used seed-based, whole-brain independent component analysis (ICA), network-of-interest ICA based and graph analysis approaches...
October 8, 2016: Neuroscience and Biobehavioral Reviews
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