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resting-state functional magnetic resonance imaging

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https://www.readbyqxmd.com/read/28927378/genome-wide-imaging-association-study-implicates-functional-activity-and-glial-homeostasis-of-the-caudate-in-smoking-addiction
#1
David C Qian, David L Molfese, Jennifer L Jin, Alexander J Titus, Yixuan He, Yafang Li, Maxime Vaissié, Humsini Viswanath, Philip R Baldwin, Ralf Krahe, Ramiro Salas, Christopher I Amos
BACKGROUND: Nearly 6 million deaths and over a half trillion dollars in healthcare costs worldwide are attributed to tobacco smoking each year. Extensive research efforts have been pursued to elucidate the molecular underpinnings of smoking addiction and facilitate cessation. In this study, we genotyped and obtained both resting state and task-based functional magnetic resonance imaging from 64 non-smokers and 42 smokers. Smokers were imaged after having smoked normally ("sated") and after having not smoked for at least 12 h ("abstinent")...
September 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28927289/accounting-for-non-gaussian-sources-of-spatial-correlation-in-parametric-fmri-paradigms-i-revisiting-cluster-based-inferences
#2
Kaundinya Gopinath, Venkatagiri Krishnamurthy, K Sathian
In a recent study Eklund et al. (Eklund et al., 2016) employing resting state functional magnetic resonance imaging (rsfMRI) data as a surrogate for null fMRI datasets posited that cluster-wise family-wise error (FWE) rate corrected inferences made using parametric statistical methods in fMRI studies over the past two decades may have been invalid, particularly for cluster defining thresholds (CDTs) less stringent than p < 0.001; principally because the spatial autocorrelation functions (sACF) of fMRI data had been modeled incorrectly to follow a Gaussian form, whereas empirical data suggested otherwise (Eklund et al...
September 19, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28926645/alterations-in-regional-homogeneity-of-resting-state-cerebral-activity-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome
#3
Yusong Lin, Yan Bai, Peng Liu, Xuejuan Yang, Wei Qin, Jianqin Gu, Degang Ding, Jie Tian, Meiyun Wang
The purpose of this study was to explore the neural mechanism in Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) using resting-state functional magnetic resonance imaging. The functional magnetic resonance imaging was performed on 31 male CP/CPPS-patients and 31 age and education matched male healthy controls on a 3-T magnetic resonance imaging unit. A two-sample t-test was adopted to reveal the regional homogeneity between the patients and healthy controls. The mean regional homogeneity values in the alerted brain regions of patients were correlated with the clinical measurements by using Pearson's correlation analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28926154/brain-functional-connectome-abnormalities-in-als-are-associated-with-disability-and-cortical-hyperexcitability
#4
Nimeshan Geevasinga, Mayuresh S Korgaonkar, Parvathi Menon, Mehdi Van den Bos, Lavier Gomes, Sheryl Foster, Matthew C Kiernan, Steve Vucic
OBJECTIVE: The present study utilized a multimodality approach encompassing connectome network combined with brain volume analysis, and assessment of cortical excitability to provide novel insights into amyotrophic lateral sclerosis (ALS) pathogenesis. METHODS: Magnetic resonance images (MRI) were acquired using a 3.0 Tesla GE Signa HDx scanner, using an 8-channel head coil. MR images for the resting state scan were acquired using echo planar imaging MR sequence, acquiring 40 contiguous axial/oblique slices...
September 19, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28924181/common-and-dissociable-regional-cerebral-blood-flow-differences-associate-with-dimensions-of-psychopathology-across-categorical-diagnoses
#5
A N Kaczkurkin, T M Moore, M E Calkins, R Ciric, J A Detre, M A Elliott, E B Foa, A Garcia de la Garza, D R Roalf, A Rosen, K Ruparel, R T Shinohara, C H Xia, D H Wolf, R E Gur, R C Gur, T D Satterthwaite
The high comorbidity among neuropsychiatric disorders suggests a possible common neurobiological phenotype. Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neuropsychiatric disorders. Regional CBF may also provide a useful biological marker across different types of psychopathology. To investigate CBF changes common across psychiatric disorders, we capitalized upon a sample of 1042 youths (ages 11-23 years) who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28922833/the-knockout-of-synapsin-ii-in-mice-impairs-social-behavior-and-functional-connectivity-generating-an-asd-like-phenotype
#6
Caterina Michetti, Angela Caruso, Marco Pagani, Mara Sabbioni, Lucian Medrihan, Gergely David, Alberto Galbusera, Monica Morini, Alessandro Gozzi, Fabio Benfenati, Maria Luisa Scattoni
Autism spectrum disorders (ASD) and epilepsy are neurodevelopmental conditions that appear with high rate of co-occurrence, suggesting the possibility of a common genetic basis. Mutations in Synapsin (SYN) genes, particularly SYN1 and SYN2, have been recently associated with ASD and epilepsy in humans. Accordingly, mice lacking Syn1 or Syn2, but not Syn3, experience epileptic seizures and display autistic-like traits that precede the onset of seizures. Here, we analyzed social behavior and ultrasonic vocalizations emitted in 2 social contexts by SynI, SynII, or SynIII mutants and show that SynII mutants display the most severe ASD-like phenotype...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28917194/selective-functional-dysconnectivity-of-the-dorsal-anterior-subregion-of-the-precuneus-in-drug-naive-major-depressive-disorder
#7
Jiajia Zhu, Xiaodong Lin, Chongguang Lin, Chuanjun Zhuo, Yongqiang Yu
BACKGROUND: Patients with major depressive disorder (MDD) have shown altered resting-state functional connectivity (rsFC) of the precuneus; however, it is unknown whether rsFC of the precuneus subregions is differentially affected in this disorder. METHODS: In this study, we aimed to clarify this issue by comparing rsFC of each precuneus subregion between patients with MDD and healthy controls. Forty-seven drug-naive patients with MDD and 47 sex-, age- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI)...
August 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28916500/early-life-stress-modulates-neural-networks-associated-with-habitual-use-of-reappraisal
#8
Elissa El Khawli, Yan Fan, Sabine Aust, Katharina Wirth, Luisa Bönke, Amie Stevense, Ana Herrera, Sophie Metz, Andrea Loayza, Malek Bajbouj, Simone Grimm
Recent evidence shows that early life stress (ELS) is associated with altered resting-state functional connectivity (RSFC) between amygdala and the prefrontal cortex, as well as with maladaptive emotion regulation strategies and negative mood. However, the relation between ELS and maladaptive emotion regulation is not deterministic. Adaptive emotion regulation strategies such as reappraisal can also ensue from experience and learning in adulthood and can prevent negative mood. The present study aims to investigate the joint influence of ELS, in particular early-life emotional abuse (EA), and habitual use of reappraisal on amygdala-centered RSFC and mood...
September 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28916181/replicability-of-time-varying-connectivity-patterns-in-large-resting-state-fmri-samples
#9
Anees Abrol, Eswar Damaraju, Robyn L Miller, Julia M Stephen, Eric D Claus, Andrew R Mayer, Vince D Calhoun
The past few years have seen an emergence of approaches that leverage temporal changes in whole-brain patterns of functional connectivity (the chronnectome). In this chronnectome study, we investigate the replicability of the human brain's inter-regional coupling dynamics during rest by evaluating two different dynamic functional network connectivity (dFNC) analysis frameworks using 7 500 functional magnetic resonance imaging (fMRI) datasets. To quantify the extent to which the emergent functional connectivity (FC) patterns are reproducible, we characterize the temporal dynamics by deriving several summary measures across multiple large, independent age-matched samples...
September 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28915082/a-combined-study-of-slc6a15-gene-polymorphism-and-the-resting-state-functional-magnetic-resonance-imaging-in-first-episode-drug-naive-major-depressive-disorder
#10
Lijuan Wang, Zhifen Liu, Xiaohua Cao, Jianying Li, Aixia Zhang, Ning Sun, Chunxia Yang, Kerang Zhang
AIMS: The SLC6A15 gene has been identified as a novel candidate gene for major depressive disorder (MDD). However, the mechanism underlying the effects of how the SLC6A15 gene affects functional brain activity of patients with MDD remains unknown. METHODS: In the present study, we investigated the effect of the SLC6A15 gene polymorphism, rs1545843, on resting-state brain function in MDD with the imaging genomic technology and the regional homogeneity (ReHo) method...
September 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28913163/general-and-selective-brain-connectivity-alterations-in-essential-tremor-a-resting-state-fmri-study
#11
Karsten Mueller, Robert Jech, Martina Hoskovcová, Olga Ulmanová, Dušan Urgošík, Josef Vymazal, Evžen Růžička
Although essential tremor is the most common movement disorder, there is little knowledge about the pathophysiological mechanisms of this disease. Therefore, we explored brain connectivity based on slow spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal in patients with essential tremor (ET). A cohort of 19 ET patients and 23 healthy individuals were scanned in resting condition using functional magnetic resonance imaging (fMRI). General connectivity was assessed by eigenvector centrality (EC) mapping...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28912749/functional-connectivity-of-the-corpus-callosum-in-epilepsy-patients-with-secondarily-generalized-seizures
#12
Syu-Jyun Peng, Yue-Loong Hsin
The corpus callosum (CC) plays an important role in generalization of seizure activity. We used resting-state function magnetic resonance imaging (rs-fMRI) to investigate the regional and interregional functional connectivity of CC in patients with magnetic resonance imaging (MRI)-negative and secondarily generalized seizures. We measured the multi-regional coherences of blood oxygen level-dependent (BOLD) signals via rs-fMRI, cortical thickness via high-resolution T1-weighted MRI, and white matter (WM) integrity via diffusion-tensor imaging in 16 epilepsy patients as well as in 16 age- and gender-matched healthy subjects...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28912568/intrinsic-neural-network-dysfunction-in-quiescent-crohn-s-disease
#13
Anne K Thomann, Martin Griebe, Philipp A Thomann, Dusan Hirjak, Matthias P Ebert, Kristina Szabo, Wolfgang Reindl, Robert C Wolf
Psychological factors and comorbidities play an important role in inflammatory bowel diseases. Such comorbidity could be associated with a specific neural phenotype. Brain regions associated with emotion regulation and self-referential processing, including areas assigned to the "default mode network" (DMN), could be promising candidates in this regard. We investigated the functional integrity of multiple intrinsic neural networks in remitted patients with Crohn's disease (CD) and sought to establish relationships between neural network connectivity and psychiatric symptoms...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911257/fatigue-in-multiple-sclerosis-the-contribution-of-resting-state-functional-connectivity-reorganization
#14
Alvino Bisecco, Federica Di Nardo, Renato Docimo, Giuseppina Caiazzo, Alessandro d'Ambrosio, Simona Bonavita, Rocco Capuano, Leonardo Sinisi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi, Antonio Gallo
OBJECTIVES: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). METHODS: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA)...
September 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28911049/aberrant-hyperconnectivity-in-the-motor-system-at-rest-is-linked-to-motor-abnormalities-in-schizophrenia-spectrum-disorders
#15
Sebastian Walther, Katharina Stegmayer, Andrea Federspiel, Stephan Bohlhalter, Roland Wiest, Petra V Viher
Motor abnormalities are frequently observed in schizophrenia and structural alterations of the motor system have been reported. The association of aberrant motor network function, however, has not been tested. We hypothesized that abnormal functional connectivity would be related to the degree of motor abnormalities in schizophrenia. In 90 subjects (46 patients) we obtained resting stated functional magnetic resonance imaging (fMRI) for 8 minutes 40 seconds at 3T. Participants further completed a motor battery on the scanning day...
September 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28910390/identify-changes-of-brain-regional-homogeneity-in-early-and-later-adult-onset-patients-with-first-episode-depression-using-resting-state-fmri
#16
Zonglin Shen, Linling Jiang, Shuran Yang, Jing Ye, Nan Dai, Xiaoyan Liu, Na Li, Jin Lu, Fang Liu, Yi Lu, Xuejin Sun, Yuqi Cheng, Xiufeng Xu
OBJECTIVE: Previous work exhibited different brain grey matter volume (GMV) changes between patients with early adult onset depression (EOD, age 18-29) and later adult onset depression (LOD, age 30-44) by using 30-year-old as the cut-off age. To identify whether regional homogeneity (ReHo) changes are also different between EOD and LOD by using same cut-off age, we used resting-state functional magnetic resonance imaging (fMRI) to detect the abnormal ReHo between patients with EOD and LOD in the present study...
2017: PloS One
https://www.readbyqxmd.com/read/28906364/altered-default-mode-network-configuration-in-posttraumatic-stress-disorder-after-earthquake-a-resting-stage-functional-magnetic-resonance-imaging-study
#17
Xiao-Dong Zhang, Yan Yin, Xiao-Lei Hu, Lian Duan, Rongfeng Qi, Qiang Xu, Guang-Ming Lu, Ling-Jiang Li
The neural substrates of posttraumatic stress disorder (PTSD) are still not fully elucidated. Hence, this study is to explore topological alterations of the default mode network (DMN) in victims with PTSD after a magnitude of 8.0 earthquake using resting-state functional magnetic resonance imaging (rs-fMRI).This study was approved by the local ethical review board, and all participants signed written informed consent. Sixty-two PTSD victims from the 2008 Sichuan earthquake and 62 matched exposed controls underwent rs-fMRI...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905408/resting-state-functional-connectivity-in-the-rat-cervical-spinal-cord-at-9-4-t
#18
Tung-Lin Wu, Feng Wang, Arabinda Mishra, George H Wilson, Nellie Byun, Li Min Chen, John C Gore
PURPOSE: Numerous studies have adopted resting-state functional MRI methods to infer functional connectivity between cortical regions, but very few have translated them to the spinal cord, despite its critical role in the central nervous system. Resting-state functional connectivity between gray matter horns of the spinal cord has previously been shown to be detectable in humans and nonhuman primates, but it has not been reported previously in rodents. METHODS: Resting-state functional MRI of the cervical spinal cord of live anesthetized rats was performed at 9...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28899821/correlation-between-brain-circuit-segregation-and-obesity
#19
Hse-Huang Chao, Yin-To Liao, Vincent Chin-Hung Chen, Cheng-Jui Li, Roger S McIntyre, Yena Lee, Jun-Cheng Weng
Obesity is a major public health problem. Herein, we aim to identify the correlation between brain circuit segregation and obesity using multimodal functional magnetic resonance imaging (fMRI) techniques and analysis. Twenty obese patients (BMI=37.66±5.07) and 30 healthy controls (BMI=22.64±3.45) were compared using neuroimaging and assessed for symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). All participants underwent resting-state fMRI (rs-fMRI) and T1-weighted imaging using a 1...
September 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28893330/changes-in-resting-state-brain-networks-after-cognitive-behavioral-therapy-for-chronic-pain
#20
A Yoshino, Y Okamoto, G Okada, M Takamura, N Ichikawa, C Shibasaki, S Yokoyama, M Doi, R Jinnin, H Yamashita, M Horikoshi, S Yamawaki
BACKGROUND: Cognitive-behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive-emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis method to examine neural changes after CBT and to assess whether brain regions predict treatment response. METHODS: We performed R-fMRI on a group of 29 chronic pain (somatoform pain disorder) patients and 30 age-matched healthy controls (T1)...
September 12, 2017: Psychological Medicine
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