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resting-state functional magnetic resonance imaging

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https://www.readbyqxmd.com/read/28441445/impact-of-aberrant-cerebral-perfusion-on-resting-state-functional-mri-a-preliminary-investigation-of-moyamoya-disease
#1
Yituo Wang, Lubin Wang, Penggang Qiao, Fugeng Sheng, Cong Han, Enmao Ye, Yu Lei, Feng Yan, Shanshan Chen, Yuyang Zhu, Guiyun Mi, Gongjie Li, Zheng Yang
The impact of chronic cerebral hypoperfusion on resting-state blood oxygen level-dependent signal fluctuations remains unknown. We aimed to determine whether chronic ischemia induces changes in amplitude of low-frequency fluctuations (ALFF) and to investigate the correlation between ALFF and perfusion-weighted magnetic resonance imaging (PWI) parameters in patients with moyamoya disease (MMD). Thirty patients with pre- and postoperative resting-state functional magnetic resonance imaging and PWI were included, and thirty normal controls underwent resting-state functional magnetic resonance imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28440813/instability-of-default-mode-network-connectivity-in-major-depression-a-two-sample-confirmation-study
#2
T Wise, L Marwood, A M Perkins, A Herane-Vives, R Joules, D J Lythgoe, W-M Luh, S C R Williams, A H Young, A J Cleare, D Arnone
Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in connectivity strength over time in major depression. We assessed stability of connectivity in major depression between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), key nodes in the DMN that are implicated in ruminative cognitions...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28439672/altered-intra-and-interregional-synchronization-in-the-absence-of-the-corpus-callosum-a-resting-state-fmri-study
#3
Long Zuo, Shuangkun Wang, Junliang Yuan, Hua Gu, Yang Zhou, Tao Jiang
Agenesis of the corpus callosum (AgCC) can result in subtle to severe cognitive deficits. Individuals with impaired cognition often show abnormalities on resting-state functional magnetic resonance imaging (rs-fMRI). This study used rs-fMRI to investigate changes in regional homogeneity (ReHo) and functional connectivity (FC) among individuals with AgCC. AgCC individuals (n = 10) and age-, sex-, and education-matched healthy control subjects (n = 19) were included in this study. The ReHo values were calculated to represent spontaneous brain activity...
April 24, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28425563/differences-in-interregional-brain-connectivity-in-children-with-unilateral-hearing-loss
#4
Matthew E Jung, Miranda Colletta, Rebecca Coalson, Bradley L Schlaggar, Judith E C Lieu
OBJECTIVES: To identify functional network architecture differences in the brains of children with unilateral hearing loss (UHL) using resting-state functional-connectivity magnetic resonance imaging (rs-fcMRI). STUDY DESIGN: Prospective observational study. METHODS: Children (7 to 17 years of age) with severe to profound hearing loss in one ear, along with their normal hearing (NH) siblings, were recruited and imaged using rs-fcMRI. Eleven children had right UHL; nine had left UHL; and 13 had normal hearing...
April 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28424611/modafinil-induced-changes-in-functional-connectivity-in-the-cortex-and-cerebellum-of-healthy-elderly-subjects
#5
Miriam Punzi, Tommaso Gili, Laura Petrosini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420981/age-related-difference-in-functional-brain-connectivity-of-mastication
#6
Chia-Shu Lin, Ching-Yi Wu, Shih-Yun Wu, Hsiao-Han Lin, Dong-Hui Cheng, Wen-Liang Lo
The age-related decline in motor function is associated with changes in intrinsic brain signatures. Here, we investigated the functional connectivity (FC) associated with masticatory performance, a clinical index evaluating general masticatory function. Twenty-six older adults (OA) and 26 younger (YA) healthy adults were recruited and assessed using the masticatory performance index (MPI) and resting-state functional magnetic resonance imaging (rs-fMRI). We analyzed the rs-fMRI FC network related to mastication, which was constructed based on 12 bilateral mastication-related brain regions according to the literature...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420978/resting-state-fmri-reveals-increased-subthalamic-nucleus-and-sensorimotor-cortex-connectivity-in-patients-with-parkinson-s-disease-under-medication
#7
Bo Shen, Yang Gao, Wenbin Zhang, Liyu Lu, Jun Zhu, Yang Pan, Wenya Lan, Chaoyong Xiao, Li Zhang
Functional connectivity (FC) between the subthalamic nucleus (STN) and the sensorimotor cortex is increased in off-medication patients with Parkinson's disease (PD). However, the status of FC between STN and sensorimotor cortex in on-medication PD patients remains unclear. In this study, resting state functional magnetic resonance imaging was employed on 31 patients with PD under medication and 31 healthy controls. Two-sample t-test was used to study the change in FC pattern of the STN, the FC strength of the bilateral STN was correlated with overall motor symptoms, while unilateral STN was correlated with offside motor symptoms...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28418398/intranasal-oxytocin-enhances-intrinsic-corticostriatal-functional-connectivity-in-women
#8
R A I Bethlehem, M V Lombardo, M-C Lai, B Auyeung, S K Crockford, J Deakin, S Soubramanian, A Sule, P Kundu, V Voon, S Baron-Cohen
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate the impact of oxytocin on resting-state connectivity between subcortical and cortical networks in women. We collected resting-state functional magnetic resonance imaging (fMRI) data on 26 typically developing women 40 min following intranasal oxytocin administration using a double-blind placebo-controlled crossover design...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28417233/a-posterior-to-anterior-shift-of-brain-functional-dynamics-in-aging
#9
Han Zhang, Annie Lee, Anqi Qiu
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI...
April 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28417219/treatment-effect-of-methylphenidate-on-intrinsic-functional-brain-network-in-medication-na%C3%A3-ve-adhd-children-a-multivariate-analysis
#10
Jae Hyun Yoo, Dohyun Kim, Jeewook Choi, Bumseok Jeong
Methylphenidate is a first-line therapeutic option for treating attention-deficit/hyperactivity disorder (ADHD); however, elicited changes on resting-state functional networks (RSFNs) are not well understood. This study investigated the treatment effect of methylphenidate using a variety of RSFN analyses and explored the collaborative influences of treatment-relevant RSFN changes in children with ADHD. Resting-state functional magnetic resonance imaging was acquired from 20 medication-naïve ADHD children before methylphenidate treatment and twelve weeks later...
April 17, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28415008/bipolar-mood-state-reflected-in-cortico-amygdala-resting-state-connectivity-a-cohort-and-longitudinal-study
#11
Roscoe O Brady, Allison Margolis, Grace A Masters, Matcheri Keshavan, Dost Öngür
BACKGROUND: Using resting-state functional magnetic resonance imaging (rsfMRI), we previously compared cohorts of bipolar I subjects in a manic state to those in a euthymic state to identify mood state-specific patterns of cortico-amygdala connectivity. Our results suggested that mania is reflected in the disruption of emotion regulation circuits. We sought to replicate this finding in a group of subjects with bipolar disorder imaged longitudinally across states of mania and euthymia METHODS: We divided our subjects into three groups: 26 subjects imaged in a manic state, 21 subjects imaged in a euthymic state, and 10 subjects imaged longitudinally across both mood states...
March 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28413234/high-dimensional-tests-for-functional-networks-of-brain-anatomic-regions
#12
Jichun Xie, Jian Kang
Exploring resting-state brain functional connectivity of autism spectrum disorders (ASD) using functional magnetic resonance imaging (fMRI) data has become a popular topic over the past few years. The data in a standard brain template consist of over 170,000 voxel specific points in time for each human subject. Such an ultra-high dimensionality makes the voxel-level functional connectivity analysis (involving four billion voxel pairs) both statistically and computationally inefficient. In this work, we introduce a new framework to identify the functional brain network at the anatomical region level for each individual...
April 2017: Journal of Multivariate Analysis
https://www.readbyqxmd.com/read/28412557/electroconvulsive-therapy-changes-the-regional-resting-state-function-measured-by-regional-homogeneity-reho-and-amplitude-of-low-frequency-fluctuations-alff-in-elderly-major-depressive-disorder-patients-an-exploratory-study
#13
Xiao-Ming Kong, Shu-Xian Xu, Yan Sun, Ke-Yong Wang, Chen Wang, Ji Zhang, Jin-Xiang Xia, Li Zhang, Bo-Jian Tan, Xin-Hui Xie
Electroconvulsive therapy (ECT) is the most effective and rapid treatment for severe major depressive disorder (MDD) in elderly patients. The mechanism of ECT is unclear, and studies on ECT in elderly MDD patients by resting-state functional magnetic resonance imaging are rare. Thirteen elderly MDD patients were scanned before and after ECT using a 3.0T MRI scanner. Regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) were processed to compare resting-state function before and after treatment...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28410136/directed-connectivity-of-brain-default-networks-in-resting-state-using-gca-and-motif
#14
Zhuqing Jiao, Huan Wang, Kai Ma, Ling Zou, Jianbo Xiang
Nowadays, there is a lot of interest in assessing functional interactions between key brain regions. In this paper, Granger causality analysis (GCA) and motif structure are adopted to study directed connectivity of brain default mode networks (DMNs) in resting state. Firstly, the time series of functional magnetic resonance imaging (fMRI) data in resting state were extracted, and the causal relationship values of the nodes representing related brain regions are analyzed in time domain to construct a default network...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28408865/tau-pathology-distribution-in-alzheimer-s-disease-corresponds-differentially-to-cognition-relevant-functional-brain-networks
#15
Oskar Hansson, Michel J Grothe, Tor Olof Strandberg, Tomas Ohlsson, Douglas Hägerström, Jonas Jögi, Ruben Smith, Michael Schöll
Neuropathological studies have shown that the typical neurofibrillary pathology of hyperphosphorylated tau protein in Alzheimer's disease (AD) preferentially affects specific brain regions whereas others remain relatively spared. It has been suggested that the distinct regional distribution profile of tau pathology in AD may be a consequence of the intrinsic network structure of the human brain. The spatially distributed brain regions that are most affected by the spread of tau pathology may hence reflect an interconnected neuronal system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28407556/functional-network-based-statistics-in-depression-theory-of-mind-subnetwork-and-importance-of-parietal-region
#16
Chien-Han Lai, Yu-Te Wu, Yuh-Ming Hou
OBJECTIVE: The functional network analysis of whole brain is an emerging field for research in depression. We initiated this study to investigate which subnetwork is significantly altered within the functional connectome in major depressive disorder (MDD). METHODS: The study enrolled 52 first-episode medication-naïve patients with MDD and 40 controls for functional network analysis. All participants received the resting-state functional imaging using a 3-Tesla magnetic resonance scanner...
April 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28403437/postretinal-structure-and-function-in-severe-congenital-photoreceptor-blindness-caused-by-mutations-in-the-gucy2d-gene
#17
Geoffrey K Aguirre, Omar H Butt, Ritobrato Datta, Alejandro J Roman, Alexander Sumaroka, Sharon B Schwartz, Artur V Cideciyan, Samuel G Jacobson
Purpose: To examine how severe congenital blindness resulting from mutations of the GUCY2D gene alters brain structure and function, and to relate these findings to the notable preservation of retinal architecture in this form of Leber congenital amaurosis (LCA). Methods: Six GUCY2D-LCA patients (ages 20-46) were studied with optical coherence tomography of the retina and multimodal magnetic resonance imaging (MRI) of the brain. Measurements from this group were compared to those obtained from populations of normally sighted controls and people with congenital blindness of a variety of causes...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28401836/insensitive-parenting-may-accelerate-the-development-of-the-amygdala-medial-prefrontal-cortex-circuit
#18
Sandra Thijssen, Ryan L Muetzel, Marian J Bakermans-Kranenburg, Vincent W V Jaddoe, Henning Tiemeier, Frank C Verhulst, Tonya White, Marinus H Van Ijzendoorn
This study examined whether the association between age and amygdala-medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28400807/modulatory-effects-of-acupuncture-on-brain-networks-in-mild-cognitive-impairment-patients
#19
Ting-Ting Tan, Dan Wang, Ju-Ke Huang, Xiao-Mei Zhou, Xu Yuan, Jiu-Ping Liang, Liang Yin, Hong-Liang Xie, Xin-Yan Jia, Jiao Shi, Fang Wang, Hao-Bo Yang, Shang-Jie Chen
Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear. In this study, 32 patients with amnestic mild cognitive impairment were randomly divided into two groups, where they received either Tiaoshen Yizhi acupuncture or sham acupoint acupuncture...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400737/reduced-resting-state-functional-connectivity-in-current-and-recovered-restrictive-anorexia-nervosa
#20
Jessica Clare Scaife, Lauren Rose Godier, Nicola Filippini, Catherine J Harmer, Rebecca J Park
Functional connectivity studies based on resting-state functional magnetic resonance imaging (rs-fMRI) have shown alterations in brain networks associated with self-referential processing, cognitive control, and somatosensory processing in anorexia nervosa (AN). This study aimed to further investigate the functional connectivity of resting-state networks (RSNs) in homogenous subsamples of individuals with restrictive AN (current and recovered) and the relationship this has with core eating disorder psychopathology...
2017: Frontiers in Psychiatry
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