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https://www.readbyqxmd.com/read/29156612/leishmanicidal-activity-of-biogenic-fe%C3%A2-o%C3%A2-nanoparticles
#1
Mehrdad Khatami, Hajar Alijani, Iraj Sharifi, Fatemeh Sharifi, Shahram Pourseyedi, Sam Kharazi, Marcos Augusto Lima Nobre, Manouchehr Khatami
Abstract: Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe₃O₄ (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanicidal efficiency of green synthesized IONPs. This is the first report of the leishmanicidal efficiency of green synthesized IONPs against Leishmania major. The resulting biosynthesized IONPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR)...
November 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29156103/abstracts
#2
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29156070/medical-crowdfunding-for-patients-undergoing-orthopedic-surgery
#3
Wesley M Durand, Joseph R Johnson, Adam E M Eltorai, Alan H Daniels
Crowdfunding for medical expenses is growing in popularity. Through several websites, patients create public campaign profiles to which donors can contribute. Research on medical crowdfunding is limited, and there have been no studies of crowdfunding in orthopedics. Active medical crowdfunding campaigns for orthopedic trauma, total joint arthroplasty, and spine surgery were queried from a crowdfunding website. The characteristics and outcomes of crowdfunding campaigns were abstracted and analyzed. For this study, 444 campaigns were analyzed, raising a total of $1,443,528...
November 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29155996/hierarchical-attention-networks-for-information-extraction-from-cancer-pathology-reports
#4
Shang Gao, Michael T Young, John X Qiu, Hong-Jun Yoon, James B Christian, Paul A Fearn, Georgia D Tourassi, Arvind Ramanthan
Objective: We explored how a deep learning (DL) approach based on hierarchical attention networks (HANs) can improve model performance for multiple information extraction tasks from unstructured cancer pathology reports compared to conventional methods that do not sufficiently capture syntactic and semantic contexts from free-text documents. Materials and Methods: Data for our analyses were obtained from 942 deidentified pathology reports collected by the National Cancer Institute Surveillance, Epidemiology, and End Results program...
November 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29155938/cerebral-autoregulation-in-cardiopulmonary-bypass-surgery-a-systematic-review
#5
Juliana R Caldas, Victoria J Haunton, Ronney B Panerai, Ludhmila A Hajjar, Thompson G Robinson
Cardiopulmonary bypass surgery is associated with a high incidence of neurological complications, including stroke, delirium and cognitive impairment. The development of strategies to reduce the incidence of such neurological events has been hampered by the lack of a clear understanding of their pathophysiology. Cerebral autoregulation (CA), which describes the ability of the brain to maintain a stable cerebral blood flow over a wide range of cerebral perfusion pressures despite changes in blood pressure, is known to be impaired in various neurological disorders...
November 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29155553/thiyl-radical-based-charge-tagging-enables-rapid-sterol-quantitation-via-mass-spectrometry
#6
Sarju Adhikari Adhikari, Yu Xia
Inspired by the high reactivity and specificity of thiyl radicals toward alkenes, we have developed a new charge derivatization meth-od to enable fast and quantitative analysis of sterols via electrospray ionization-mass spectrometry (ESI-MS). Thioglycolic acid (TGA), a commercially available compound, has been established as a highly efficient tagging reagent. Initiated from photochemical reactions, the thiyl radical derived from TGA abstracts an allylic hydrogen in the B ring of sterols, forming a radical intermediate which rapidly recombines with a second thiyl radical to produce the final tagged product...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29155493/the-crystal-structure-and-catalytic-mechanism-of-hydroxynitrile-lyase-from-passion-fruit-passiflora-edulis
#7
Fumihiro Motojima, Aem Nuylert, Yasuhisa Asano
Hydroxynitrile lyases (HNLs) are enzymes used in the synthesis of chiral cyanohydrins. The HNL from Passiflora edulis (PeHNL) is R-selective and is the smallest HNL known to date. The crystal structures of PeHNL and its C-terminal peptide depleted derivative were determined by molecular replacement method using the template structure of a heat stable protein, SP1, from Populus tremula at 2.8 Å and 1.8 Å resolution, respectively. PeHNL belongs to dimeric α+β barrel superfamily consisting of a central β-barrel in the middle of a dimer...
November 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29155436/enzyme-replacement-therapy-for-infantile-onset-pompe-disease
#8
REVIEW
Min Chen, Lingli Zhang, Shuyan Quan
BACKGROUND: Infantile-onset Pompe disease is a rare and progressive autosomal-recessive disorder caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Current treatment involves enzyme replacement therapy (with recombinant human alglucosidase alfa) and symptomatic therapies (e.g. to control secretions). Children who are cross-reactive immunological material (CRIM)-negative require immunomodulation prior to commencing enzyme replacement therapy.Enzyme replacement therapy was developed as the most promising therapeutic approach for Pompe disease; however, the evidence is lacking, especially regarding the optimal dose and dose frequency...
November 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29155140/pregnancy-and-parturition-negatively-impact-vaginal-angle-and-alters-expression-of-vaginal-mmp-9
#9
Sallie Oliphant, Timothy Canavan, Stacy Palcsey, Leslie Meyn, Pamela Moalli
BACKGROUND: Parity is the greatest risk factor for the development of pelvic organ prolapse. The normally supported vagina is pulled up and back over the levator ani. Loss of vaginal angulation has been associated with prolapse and may represent injury to the vaginal supportive tissues. OBJECTIVE: We propose that 1) pregnancy and delivery impact support to the vagina leading to loss of vaginal angle; 2) vaginal angulation is restored postpartum; and 3) uncomplicated vaginal delivery (VD) is associated with accelerated remodeling of the vaginal fibrillar matrix...
November 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29155082/association-of-gastric-intestinal-metaplasia-and-east-asian-ethnicity-with-the-risk-of-gastric-adenocarcinoma-in-a-u-s-population
#10
Alyssa Y Choi, Lisa L Strate, Matthew C Fix, Rodney A Schmidt, Alexander R Ende, Matthew M Yeh, John M Inadomi, Joo Ha Hwang
BACKGROUND AND AIMS: Although the incidence of gastric cancer is higher than esophageal cancer in the United States, no screening or surveillance guidelines exist. The aim of this study is to evaluate the association between gastric intestinal metaplasia and the risk of gastric cancer in a U.S. tertiary care system with a large immigrant population. METHODS: This is a retrospective case-control study with cases of biopsy-proven gastric cancer matched (by age and gender) to controls without gastric cancer who had undergone EGD...
November 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29154691/optimal-screening-methods-to-detect-cardiac-disorders-in-athletes-an-evidence-based-review
#11
Zachary K Winkelmann, Ashley K Crossway
Reference/Citation:  Harmon KG, Zigman M, Drezner JA. The effectiveness of screening history, physical exam, and ECG to detect potentially lethal cardiac disorders in athletes: a systematic review/meta-analysis. J Electrocardiol. 2015;48(3):329-338. CLINICAL QUESTION:   Which screening method should be considered best practice to detect potentially lethal cardiac disorders during the preparticipation physical examination (PE) of athletes? DATA SOURCES:   The authors completed a comprehensive literature search of MEDLINE, CINAHL, Cochrane Library, Embase, Physiotherapy Evidence Database (PEDro), and SPORTDiscus from January 1996 to November 2014...
November 20, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29154622/how-does-not-left-become-right-electrophysiological-evidence-for-a-dynamic-conflict-bound-negation-processing-account
#12
Carolin Dudschig, Barbara Kaup
Human thought and language is traditionally considered as abstract, amodal, and symbolic. However, recent theories propose that high-level human cognition is directly linked to basic, modal biological systems such as sensorimotor areas. Despite this influential representational debate very little is known regarding whether the mechanisms involved in sensorimotor control are also shared with higher-level cognitive processes, such as language comprehension. We investigated negation as a universal of human language, addressing two key questions: (a) Does negation result in a conflict-like representation? (b) Does negation trigger executive control adjustments in a similar manner as standard information processing conflicts do (e...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154573/topics-in-the-journal-of-counseling-psychology-1963-2015
#13
JungSu Oh, Alan E Stewart, Rosemary E Phelps
Historical trends in a scientific field should be apparent in the changing content of journal articles over time. Using a topic modeling approach, a statistical method for quantifying the thematic content of text, 70 topics were extracted from the abstracts of 3,603 articles published in the Journal of Counseling Psychology from 1963 to 2015. After examining interpretability of 70 topics derived from the model, 64 meaningful topics and their trends were named. In addition, the authors also classified some of the related topics into 4 categories-counseling process and outcome, multiculturalism, research methodology, and vocational psychology...
November 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29154478/on-the-dual-reactivity-of-a-nucleophilic-dihydrido-diborane-reaction-at-the-b-b-bond-and-or-the-b-h-bond
#14
Anna Widera, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The electron-rich, double-base stabilized dihydrido-diborane(4) [HB(hpp)]2 (hpp = 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinate) combines two different, easily accessible reactive sites: the B-B and B-H bond. We hereby report two basically similar reactions of [HB(hpp)]2 with catecholborane and B-chlorocatecholborane unsuspectedly resulting in two different reactivities. While reaction of the diborane with two equivalents of HB(cat) proceeded under formation of a cationic triborane with a (3c2e) bond, [{HB(μ-hpp)}2(μ-BH2)]+, reaction with ClB(cat) led to hydride-chloride substitution yielding [ClB(hpp)]2...
November 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29154477/mutagenesis-of-sequence-determinants-of-truncated-porcine-alox15-induces-changes-in-the-reaction-specificity-by-altering-the-catalytic-mechanism-of-initial-hydrogen-abstraction
#15
Àngels González-Lafont, Patricia Saura, Ilya Kaganer, Dagmar Heydeck, José M Lluch, Hartmut Kühn
The reaction specificity of lipoxygenases is of physiological relevance since the various oxygenation products exhibit different biological activities. Among mammalian ALOX15 orthologs there are arachidonic acid 12- and 15-lipoxygenating enzymes and recent studies suggested an evolutionary switch in that reaction specificity during late primate development. Previous reports showed that 12-lipoxygenating ALOX15 orthologs can be converted to 15-lipoxygenating enzymes by site-directed mutagenesis of some sequence determinants...
November 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29154395/incidence-and-risk-factors-for-mortality-after-release-from-prison-in-australia-a-prospective-cohort-study
#16
Simon J Forsyth, Megan Carroll, Nicholas Lennox, Stuart A Kinner
AIMS: To estimate the incidence and identify risk factors for mortality in adults released from prisons in the state of Queensland, Australia. DESIGN: Prospective cohort study, linking baseline survey data with a national death register. SETTING: Selected prisons within Queensland, Australia. PARTICIPANTS: Adults (N=1320) recruited in Queensland prisons within 6 weeks of expected release, between August 2008 and July 2010, followed for up to 4...
November 20, 2017: Addiction
https://www.readbyqxmd.com/read/29154160/gender-identity-better-than-sex-explains-individual-differences-in-episodic-and-semantic-components-of-autobiographical-memory-and-future-thinking
#17
Laurie Compère, Eirini Rari, Thierry Gallarda, Adèle Assens, Marion Nys, Sandrine Coussinoux, Sébastien Machefaux, Pascale Piolino
A recently tested hypothesis suggests that inter-individual differences in episodic autobiographical memory (EAM) are better explained by individual identification of typical features of a gender identity than by sex. This study aimed to test this hypothesis by investigating sex and gender related differences not only in EAM but also during retrieval of more abstract self-knowledge (i.e., semantic autobiographical memory, SAM, and conceptual self, CS), and considering past and future perspectives. No sex-related differences were identified, but regardless of the sex, feminine gender identity was associated with clear differences in emotional aspects that were expressed in both episodic and more abstract forms of AM, and in the past and future perspectives, while masculine gender identity was associated with limited effects...
November 16, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29153941/the-impact-of-readmission-hospital-on-failure-to-rescue-rates-following-major-urologic-cancer-surgery
#18
Jasmir G Nayak, Sarah K Holt, Jonathan L Wright, Matthew Mossanen, Atreya Dash, John L Gore
PURPOSE: Patients readmitted to secondary hospitals rather than the primary hospital where their surgery took place may be at risk for poorer outcomes. We sought to evaluate the effect of site of readmission on failure-to-rescue complication rates following urologic cancer surgery. MATERIALS AND METHODS: Retrospective review of major urologic cancer surgeries in the Washington State Comprehensive Hospital Abstract Reporting System between 1998 and 2013. Failure-to-rescue (FTR) rates, defined as inpatient death after a complication requiring hospital readmission, were compared between patients readmitted to their primary hospital with those readmitted to a secondary hospital...
November 16, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29153159/a-100-year-review-total-mixed-ration-feeding-of-dairy-cows
#19
David J Schingoethe
Total mixed rations (TMR) as we know them today did not exist in 1917. In fact, TMR are an invention of primarily the last half of the past 100 yr. Prior to that time many dairy herds were fed only forages, but dairy producers started moving toward TMR feeding as milk production per cow increased, herds became larger, freestall and large-group handling of cows became more common, and milking parlors became more prevalent. The earliest known reports in the Journal of Dairy Science of feeding "complete rations" or TMR may have appeared in the 1950s, but those studies were often reported only as abstracts at annual meetings of the American Dairy Science Association or in extension-type publications...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153049/uk-stroke-forum-abstracts-2017
#20
(no author information available yet)
No abstract text is available yet for this article.
November 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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