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https://www.readbyqxmd.com/read/28934779/what-are-the-predictors-of-altered-central-pain-modulation-in-chronic-musculoskeletal-pain-populations-a-systematic-review
#1
Jacqui Clark, Jo Nijs, Gillian Yeowell, Peter Charles Goodwin
BACKGROUND: Altered central pain modulation is the predominant pain mechanism in a proportion of chronic musculoskeletal pain disorders and is associated with poor outcomes. Although existing studies predict poor outcomes such as persistent pain and disability, to date there is little consensus on what factors specifically predict altered central pain modulation. OBJECTIVES: To review the existing literature on the predictive factors specifically for altered central pain modulation in musculoskeletal pain populations...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934740/jahrestagung-der-deutschen-%C3%A3-sterreichischen-und-schweizerischen-gesellschaften-f%C3%A3-r-h%C3%A3-matologie-und-medizinische-onkologie-stuttgart-29-september-3-oktober-2017-abstracts
#2
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28934401/lessons-learned-for-reducing-the-negative-impact-of-adverse-events-on-patients-health-professionals-and-healthcare-organizations
#3
Jose Joaquin Mira, Susana Lorenzo, Irene Carrillo, Lena Ferrús, Carmen Silvestre, Pilar Astier, Fuencisla Iglesias-Alonso, Jose Angel Maderuelo, Pastora Pérez-Pérez, Maria Luisa Torijano, Elena Zavala, Susan D Scott
Purpose: To summarize the knowledge about the aftermath of adverse events (AEs) and develop a recommendation set to reduce their negative impact in patients, health professionals and organizations in contexts where there is no previous experiences and apology laws are not present. Data sources: Review studies published between 2000 and 2015, institutional websites and experts' opinions on patient safety. Study selection: Studies published and websites on open disclosure, and the second and third victims' phenomenon...
August 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28934215/tracing-the-temporal-stability-of-autism-spectrum-diagnosis-and-severity-as-measured-by-the-autism-diagnostic-observation-schedule-a-systematic-review-and-meta-analysis
#4
Łucja Bieleninik, Maj-Britt Posserud, Monika Geretsegger, Grace Thompson, Cochavit Elefant, Christian Gold
BACKGROUND: Exploring ways to improve the trajectory and symptoms of autism spectrum disorder is prevalent in research, but less is known about the natural prognosis of autism spectrum disorder and course of symptoms. The objective of this study was to examine the temporal stability of autism spectrum disorder and autism diagnosis, and the longitudinal trajectories of autism core symptom severity. We furthermore sought to identify possible predictors for change. METHODS: We searched PubMed, PsycInfo, EMBASE, Web of Science, Cochrane Library up to October 2015 for prospective cohort studies addressing the autism spectrum disorder/autism diagnostic stability, and prospective studies of intervention effects...
2017: PloS One
https://www.readbyqxmd.com/read/28934126/a-multi-objective-partition-method-for-marine-sensor-networks-based-on-degree-of-event-correlation
#5
Dongmei Huang, Chenyixuan Xu, Danfeng Zhao, Wei Song, Qi He
Existing marine sensor networks acquire data from sea areas that are geographically divided, and store the data independently in their affiliated sea area data centers. In the case of marine events across multiple sea areas, the current network structure needs to retrieve data from multiple data centers, and thus severely affects real-time decision making. In this study, in order to provide a fast data retrieval service for a marine sensor network, we use all the marine sensors as the vertices, establish the edge based on marine events, and abstract the marine sensor network as a graph...
September 21, 2017: Sensors
https://www.readbyqxmd.com/read/28934086/towards-ontology-based-decision-support-systems-for-complex-ultrasound-diagnosis-in-obstetrics-and-gynecology
#6
P Maurice, F Dhombres, E Blondiaux, S Friszer, L Guilbaud, N Lelong, B Khoshnood, J Charlet, N Perrot, E Jauniaux, D Jurkovic, J-M Jouannic
INTRODUCTION: We have developed a new knowledge base intelligent system for obstetrics and gynecology ultrasound imaging, based on an ontology and a reference image collection. This study evaluates the new system to support accurate annotations of ultrasound images. We have used the early ultrasound diagnosis of ectopic pregnancies as a model clinical issue. MATERIAL AND METHODS: The ectopic pregnancy ontology was derived from medical texts (4260 ultrasound reports of ectopic pregnancy from a specialist center in the UK and 2795 Pubmed abstracts indexed with the MeSH term "Pregnancy, Ectopic") and the reference image collection was built on a selection from 106 publications...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28933986/the-antiangiogenesis-effect-of-pirfenidone-in-wound-healing-in-vitro
#7
Xiao'an Liu, Yangfan Yang, Xiujuan Guo, Liling Liu, Kaili Wu, Minbin Yu
Abstracts Background: Pirfenidone is mostly used in antifibrotic and anti-inflammatory therapies. We have previously demonstrated that pirfenidone had antifibrotic and anti-inflammatory effects on the wound healing process after glaucoma filtration surgery in vitro and in vivo. Since the wound healing and reactive scarring process simultaneously involves inflammation, fibrosis, and angiogenesis, and angiogenesis plays a more important role in chronic or prolonged wound healing, we tried to explore the antiangiogenesis effect in pirfenidone and its potential multitarget function in regulating excessive scarring...
September 21, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28933875/-sex-differences-in-left-handedness-a-meta-analysis-of-144-studies-correction-to-papadatou-pastou-et-al-2008
#8
(no author information available yet)
Reports an error in "Sex differences in left-handedness: A meta-analysis of 144 studies" by Marietta Papadatou-Pastou, Maryanne Martin, Marcus R. Munafò and Gregory V. Jones (Psychological Bulletin, 2008[Sep], Vol 134[5], 677-699). In the article the statistical evidence is weaker than reported for the moderating effect of writing hand compared to all the other instruments (reported finding: Q(1) = 8.36, p = .02; corrected finding: Q(1) = 3.17, p = .075). While the statistical evidence is thus somewhat weaker on this particular point, the broad conclusions of the article remain unchanged...
October 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28933805/perioperative-administration-of-buffered-versus-non-buffered-crystalloid-intravenous-fluid-to-improve-outcomes-following-adult-surgical-procedures
#9
REVIEW
Sohail Bampoe, Peter M Odor, Ahilanandan Dushianthan, Elliott Bennett-Guerrero, Suzie Cro, Tong J Gan, Michael Pw Grocott, Michael Fm James, Michael G Mythen, Catherine Mn O'Malley, Anthony M Roche, Kathy Rowan, Edward Burdett
BACKGROUND: Perioperative fluid strategies influence clinical outcomes following major surgery. Many intravenous fluid preparations are based on simple solutions, such as normal saline, that feature an electrolyte composition that differs from that of physiological plasma. Buffered fluids have a theoretical advantage of containing a substrate that acts to maintain the body's acid-base status - typically a bicarbonate or a bicarbonate precursor such as maleate, gluconate, lactate, or acetate...
September 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28933700/a-secondary-analysis-of-longitudinal-prevalence-data-to-determine-the-use-of-pressure-ulcer-preventive-measures-in-dutch-nursing-homes-2005-2014
#10
Martin Wf van Leen, Joseph Mga Schols, Steven Er Hovius, Ruud Jg Halfens
Pressure ulcers (PUs) are an important and distressing problem in Dutch nursing homes. A secondary analysis of longitudinal data from the Dutch National Prevalence Measurement of Care Problems (LPZ) - an annual, multicenter, point-prevalence survey - was conducted for the years 2005-2014 to determine the use of specific recommended PU preventive measures from the European Pressure Ulcer Advisory Panel 1998, the National Pressure Ulcer Advisory Panel/European Pressure Ulcer Advisory Panel 2009, and the 2002 and 2011 Dutch PU guidelines...
September 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28933029/tuning-tribological-performance-of-layered-zirconium-phosphate-nanoplatelets-in-oil-by-surface-and-interlayer-modifications
#11
Xiao Han, Huaisong Yong, Dazhi Sun
Two-dimensional (2D) inorganic layered nanoplatelets exhibit superior lubricating properties in both solid states and oil dispersions. In this paper, we have systematically investigated the effects of surface and interlayer modifications on the tribological performance of layered α-zirconium phosphate (ZrP) nanoplatelets in mineral oil. The pristine layered ZrP nanoplatelets were first reacted with silanes of different alkyl chains to achieve outer surface modifications, followed by intercalation with different alkyl amines to alter the interlayer spacing...
September 20, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28933014/size-exclusion-chromatography-ion-mobility-mass-spectrometry-coupling-a-step-toward-structural-biology
#12
Guillaume Van der Rest, Frédéric Halgand
Noncovalent interactions are essential for the structural organization of biomacromolecules in cells. For this reason, the study of the biophysical, dynamic, and architectural interactions among biomacromolecules is essential. Since mass spectrometry requires compatible solutions while preserving the noncovalent bonding network, we envisioned that size exclusion chromatography coupled with ion mobility and mass spectrometry would be a valuable technique to desalt the initial sample and provide solution and gas-phase structural information in a single stage experiment...
September 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28932998/msireader-v1-0-evolving-open-source-mass-spectrometry-imaging-software-for-targeted-and-untargeted-analyses
#13
Mark T Bokhart, Milad Nazari, Kenneth P Garrard, David C Muddiman
A major update to the mass spectrometry imaging (MSI) software MSiReader is presented, offering a multitude of newly added features critical to MSI analyses. MSiReader is a free, open-source, and vendor-neutral software written in the MATLAB platform and is capable of analyzing most common MSI data formats. A standalone version of the software, which does not require a MATLAB license, is also distributed. The newly incorporated data analysis features expand the utility of MSiReader beyond simple visualization of molecular distributions...
September 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28932996/what-hinders-electron-transfer-dissociation-etd-of-dna-cations
#14
Yvonne Hari, Christian J Leumann, Stefan Schürch
Radical activation methods, such as electron transfer dissociation (ETD), produce structural information complementary to collision-induced dissociation. Herein, electron transfer dissociation of 3-fold protonated DNA hexamers was studied to gain insight into the fragmentation mechanism. The fragmentation patterns of a large set of DNA hexamers confirm cytosine as the primary target of electron transfer. The reported data reveal backbone cleavage by internal electron transfer from the nucleobase to the phosphate linker leading either to a•/w or d/z• ion pairs...
September 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28932966/regorafenib-in-advanced-hepatocellular-carcinoma-hcc-considerations-for-treatment
#15
Kyung Kim, Reena Jha, Petra A Prins, Hongkun Wang, Monica Chacha, Marion L Hartley, Aiwu Ruth He
PURPOSE: We report our institutional observations of ten patients with advanced hepatocellular carcinoma (HCC) (seven and three were Child-Pugh class A and B, respectively) who received compassionate regorafenib therapy between June 2016 and January 2017. These patients did not fit the rigid criteria of a clinical trial and represented the use of regorafenib in an everyday clinic situation. METHODS: Regorafenib (160 mg P.O. daily) was administered to patients on a 4-week cycle (3 weeks on, 1 week off) until disease progression (assessed using mRECIST criteria) or discontinuation secondary to toxicity (assessed using CTCAE criteria)...
September 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28932958/sensitive-determination-of-cadmium-using-solidified-floating-organic-drop-microextraction-slotted-quartz-tube-flame-atomic-absorption-spectroscopy
#16
Erhan Akkaya, Dotse Selali Chormey, Sezgin Bakırdere
In this study, solidified floating organic drop microextraction (SFODME) by 1-undecanol was combined with slotted quartz tube flame atomic absorption spectrometry (SQT-FAAS) for the determination of cadmium at trace levels. Formation of a complex with 4,4'-dimethyl-2,2'-bipyridine facilitated the extraction of cadmium from aqueous solutions. Several chemical variables were optimized in order to obtain high extraction outputs. Parameters such as concentration of the ligand, pH, and amount of buffer solution were optimized to enhance the formation of cadmium complex...
September 20, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28932891/identification-of-terpenes-and-essential-oils-by-means-of-static-headspace-gas-chromatography-ion-mobility-spectrometry
#17
Roman Rodríguez-Maecker, Eduardo Vyhmeister, Stefan Meisen, Antonio Rosales Martinez, Andriy Kuklya, Ursula Telgheder
Static headspace gas chromatography-ion mobility spectrometry (SHS GC-IMS) is a relatively new analytical technique that has considerable potential for analysis of volatile organic compounds (VOCs). In this study, SHS GC-IMS was used for the identification of the major terpene components of various essential oils (EOs). Based on the data obtained from 25 terpene standards and 50 EOs, a database for fingerprint identification of characteristic terpenes and EOs was generated utilizing SHS GC-IMS for authenticity testing of fragrances in foods, cosmetics, and personal care products...
September 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28932887/microchip-capillary-gel-electrophoresis-combined-with-lectin-affinity-enrichment-employing-magnetic-beads-for-glycoprotein-analysis
#18
Nicole Y Engel, Victor U Weiss, Christian Wenz, Susanne Glück, Andreas Rüfer, Martin Kratzmeier, Martina Marchetti-Deschmann, Günter Allmaier
Due to the constant search for reliable methods to investigate glycoproteins in complex biological samples, an alternative approach combining affinity enrichment with rapid and sensitive analysis on-a-chip is presented. Glycoproteins were specifically captured by lectin-coated magnetic beads, eluted by competitive sugars, and investigated with microchip capillary gel electrophoresis (MCGE), i.e., CGE-on-a-chip. We compared our results to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) data, which turned out to be in very good agreement...
September 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28932884/facile-and-easily-popularized-synthesis-of-l-cysteine-functionalized-magnetic-nanoparticles-based-on-one-step-functionalization-for-highly-efficient-enrichment-of-glycopeptides
#19
Xiaoyan Feng, Chunhui Deng, Mingxia Gao, Xiangmin Zhang
Protein glycosylation is one of the most important post-translational modifications. Also, efficient enrichment and separation of glycopeptides from complex samples are crucial for the thorough analysis of glycosylation. Developing novel hydrophilic materials with facile and easily popularized synthesis is an urgent need in large-scale glycoproteomics research. Herein, for the first time, a one-step functionalization strategy based on metal-organic coordination was proposed and Fe3O4 nanoparticles were directly functionalized with zwitterionic hydrophilic L-cysteine (L-Cys), greatly simplifying the synthetic procedure...
September 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28932883/helicase-dependent-isothermal-amplification-a-novel-tool-in-the-development-of-molecular-based-analytical-systems-for-rapid-pathogen-detection
#20
REVIEW
Susana Barreda-García, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, Arturo J Miranda-Ordieres, María Jesús Lobo-Castañón
Highly sensitive testing of nucleic acids is essential to improve the detection of pathogens, which pose a major threat for public health worldwide. Currently available molecular assays, mainly based on PCR, have a limited utility in point-of-need control or resource-limited settings. Consequently, there is a strong interest in developing cost-effective, robust, and portable platforms for early detection of these harmful microorganisms. Since its description in 2004, isothermal helicase-dependent amplification (HDA) has been successfully applied in the development of novel molecular-based technologies for rapid, sensitive, and selective detection of viruses and bacteria...
September 20, 2017: Analytical and Bioanalytical Chemistry
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