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magnesium levels in acute myocardial infarction

Z J Liu, H T Miao, S P Nie
Objective: To analyze the risk factors of cardiac rupture in patients with acute myocardial infarction. Methods: Clinical data were analyzed from 10 284 acute myocardial infarction patients admitted to Beijing Anzhen Hospital from January 2012 to March 2015. Cardiac rupture occurred in 81 patients, including 67 patients of acute left ventricular free wall rupture and 14 patients of ventricular septal defect, were retrospectively analyzed. Binary logistics regression analysis was performed to analyze the risk factors of cardiac rupture...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Niyada Naksuk, Tiffany Hu, Chayakrit Krittanawong, Charat Thongprayoon, Sunita Sharma, Jae Yoon Park, Andrew N Rosenbaum, Prakriti Gaba, Ammar M Killu, Alan M Sugrue, Thoetchai Peeraphatdit, Vitaly Herasevich, Malcolm R Bell, Peter A Brady, Suraj Kapa, Samuel J Asirvatham
BACKGROUND: Although electrolyte disturbances may affect cardiac action potential, little is known about the association between serum magnesium and corrected QT (QTc) interval as well as clinical outcomes. METHODS: A consecutive 8498 patients admitted to the Mayo Clinic Hospital-Rochester cardiac care unit (CCU) from January 1, 2004 through December 31, 2013 with 2 or more documented serum magnesium levels, were studied to test the hypothesis that serum magnesium levels are associated with in-hospital mortality, sudden cardiac death, and QTc interval...
February 2017: American Journal of Medicine
Gökhan Çiçek, Sadık Kadri Açıkgoz, Çağrı Yayla, Harun Kundi, Mehmet İleri
BACKGROUND: Although magnesium (Mg) has been proposed as a useful biomarker for predicting atherothrombosis, the association between Mg and acute stent thrombosis (ST) after primary percutaneous coronary intervention (p-PCI) for ST-segment elevation myocardial infarction (STEMI) has not yet been defined. OBJECTIVES: We aimed to examine whether admission Mg levels predicted the development of acute ST after p-PCI in STEMI patients. METHODS AND RESULTS: A total of 2633 patients with STEMI who underwent p-PCI were retrospectively analyzed...
January 2016: Coronary Artery Disease
Guipeng An, Zhongqi Du, Xiao Meng, Tao Guo, Rui Shang, Jifu Li, Fengshuang An, Wenjing Li, Cheng Zhang
OBJECTIVES: We investigated the association of serum magnesium (Mg) levels and major adverse cardiac events (MACEs) after drug-eluting stent (DES) implantation. BACKGROUND: Mg depletion plays a key role in the pathphysiologic features of diabetes mellitus, hypertension, thrombosis, arrhythmias and coronary artery disease. Whether the depletion is related to the long-term prognosis of DES implantation is not known. METHODS: From 2008 to 2011, we enrolled 414 consecutive patients <50 years old who underwent DES implantation for acute coronary syndrome...
2014: PloS One
Iu A Siniavskiĭ, V A Kraĭsman, Zh M Suleĭmenova
The article is dedicated to the use of a specialized fermented milk product on the basis of soybeans in cardiology practice. 45 patients of both sexes (27 men and 18 women) aged 38 to 69 years (mean age 53.7 +/- 3.1 years) who underwent macrofocal myocardial infarction and abide in the acute period and the period of early rehabilitation have been observed. The data obtained by the comparison of the dynamics of clinical, laboratory and functional parameters in patients, strongly suggests the possibility of increasing the effectiveness of the basic treatment by anti-atherogenic diet with fermented soy drink, enriched with magnesium salts, water-soluble forms of beta-carotene and alpha-tocopherol, ascorbic acid and selenium...
2013: Voprosy Pitaniia
P K Chakraborty, M R Hoque, M R Islam, U K Paul, F Husain
This case control cross sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with Cardiology Department of Mymensingh Medical College Hospital, Mymensingh during the period of July 2004 to June 2005. The aim of the study was to explore the status of serum magnesium among acute myocardial infarction (AMI) patients as a means to monitor the possibility of management of these patients. A total of 100 subjects were selected and were grouped as Group I (50 healthy control subjects) and Group II (50 subjects of AMI Cases)...
January 2014: Mymensingh Medical Journal: MMJ
Elie El-Charabaty, Chadi Saifan, Mokhtar Abdallah, Ali Naboush, Daniel Glass, Georges Azzi, Yorg Azzi, Ahsan Khan, Hassan Baydoun, Chetana Rondla, Ninad Parekh, Suzanne El-Sayegh
Several case reports have been written regarding the relationship between the use of proton pump inhibitors (PPI) and hypomagnesemia. Some of these reported cases have electrocardiogram abnormalities where electrolytes deficiencies were the contributing factor for these events. This study investigates the correlation between different arrhythmias and the use of PPI and hypomagnesaemia incidence. Four-hundred and twenty-one patients admitted to the critical care unit with unstable angina, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction were included in this study...
2013: International Journal of General Medicine
Ramesh Ramasamy, Sathish Babu Murugaiyan, Niranjan Gopal, Rachel Shalini
BACKGROUND: Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI. AIM: To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI. DESIGN AND SETTINGS: Case control study was conducted in South Indian male population with AMI within six hours of onset of symptoms...
May 2013: Journal of Clinical and Diagnostic Research: JCDR
Mohammad Irfan Akhtar, Hameed Ullah, Mohammad Hamid
Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system levels. The analgesic properties are due to NMDA receptor blocking action. Mg++ is beneficial in acute Myocardial Infarction, protection during open heart surgery and treatment and prevention of heart rhythm disturbances...
December 2011: JPMA. the Journal of the Pakistan Medical Association
Chang-Sheng Du, Rui-Fang Yang, Shu-Wei Song, Yi-Ping Wang, Jiu-Hong Kang, Ru Zhang, Ding-Feng Su, Xin Xie
Danshen has been used in traditional Chinese medicine for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear. In the present study, we demonstrated that in a rat model of acute myocardial infarction, the treatment with magnesium lithospermate B (MLB), the representative component of phenolic acids in Danshen, significantly reduced the infarct size and the blood lactate dehydrogenase level. In contrast, tanshinone IIA, the representative component of lipophilic tanshinones in Danshen, had no such protective effects...
2010: Frontiers in Pharmacology
Tomofumi Takaya, Masashi Okamoto, Keiko Yodoi, Katsuya Hata, Yoichi Kijima, Hideto Nakajima, Yuji Nishikawa, Tomoyuki Kita, Mitsuaki Ito, Toshihiko Seo, Seinosuke Kawashima
An 83-year-old female, who had a history of anterior myocardial infarction, was treated for Alzheimer's disease with donepezil. She suffered from repeated diarrhea and vomiting, and experienced syncope. She was admitted to our hospital and was diagnosed with acute colitis and syncope. On admission, her heart rate was 54 beats/min with regular rhythm. Laboratory data showed a low plasma potassium level. Electrocardiogram (ECG) showed poor R progression, ST elevation, negative T in precordial leads, and marked QT prolongation...
December 2009: Journal of Cardiology
Panayotis Fantidis
Intracellular cAMP is an ubiquitous intracellular second messenger that regulates important cellular functions. Intracellular cAMP levels are regulated by the enzymes adenylyl cyclase and phosphodiesterases. The role of cAMP in atherosclerosis is not widely accepted and incompletely characterized. Several reports support a role of cAMP in atherogenesis by modulating the function of vascular endothelium, the production of reactive oxygen species, the recruitment of circulating monocytes to the artery wall and their differentiation into macrophages- foam cells, by controlling the expression of pro- and anti-inflammatory interleukins, and regulating serum levels of triglycerides and cholesterol...
July 2010: Current Vascular Pharmacology
Dong-Ri Li, Li Quan, Bao-Li Zhu, Takaki Ishikawa, Tomomi Michiue, Dong Zhao, Chiemi Yoshida, Jian-Hua Chen, Qi Wang, Ayumi Komatsu, Yoko Azuma, Hitoshi Maeda
Previous studies have suggested the usefulness of postmortem serum calcium (Ca) and magnesium (Mg) for investigating cause of death. The present study investigated their levels in the pericardial fluid of serial autopsy cases of adults within 48 h postmortem (n=385), including fatalities from blunt injury (n=57), sharp instrument injury (n=9), mechanical asphyxiation (n=28), salt- and freshwater drowning (n=14 and n=61, respectively), fire fatality (n=35), intoxication (n=23), hypothermia (cold exposure, n=12), hyperthermia (heat stroke, n=7), acute cardiac death (ACD, n=86), pneumonia (n=9) and spontaneous cerebral hemorrhage (n=11)...
April 2009: Legal Medicine
O I Pisarenko, L I Serebriakova, O V Tsikitishvili, I M Studneva
The aim of this study was to evaluate the effects of intravenous infusion of potassium-magnesium aspartate (K-Mg-Asp), a glucose-insulin-potassium cocktail (GIK), a combination of glucose, insulin and potassium aspartate (GIKAsp), and insulin (I) alone during reperfusion after myocardial regional ischemia on metabolism of the risk area (AR) and cardiomyocyte membrane damage in rats in vivo. Acute myocardial infarction (MI) was induced by 40-min occlusion of the anterior descending coronary artery followed by 60-min reperfusion...
November 2008: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
A G Reznik
The informative value of the levels of calcium, potassium, sodium, magnesium, and glucose was estimated in individuals who had suddenly died from acute coronary insufficiency or acute myocardial infarction in the prenecrotic phase. The informational variations in the concentrations of electrolytes and glucose were found to reflect the differences available in the pathogenesis of an ischemic process in acute coronary insufficiency and acute myocardial infarction in the prenecrotic phase.
July 2008: Arkhiv Patologii
Arthur J Siegel, James Januzzi, Patrick Sluss, Elizabeth Lee-Lewandrowski, Malissa Wood, Terry Shirey, Kent B Lewandrowski
We measured analytes in collapsed Boston Marathon runners to compare with changes in asymptomatic runners. Of collapsed runners at the 2007 marathon, 18.2% had a measurable cardiac troponin T (cTnT) value with a mean postrace level of 0.017 ng/mL (0.017 microg/L; SD, 0.02 ng/mL [0.02 microg/L]). Three subjects had cTnT values above the cutoff (0.10 ng/mL [0.10 microg/L]) typically used for the diagnosis of acute myocardial infarction. The mean and median N-terminal pro-B-type natriuretic peptide levels were 73 ng/L (SD, 77...
June 2008: American Journal of Clinical Pathology
Leena Kuruvilla, Chandrasekharan Cheranellore Kartha
Cerium has been implicated in the pathogenesis of cardiac disorders such as acute myocardial infarction and endomyocardial fibrosis (EMF). A geochemical hypothesis for the causation of EMF linked the cardiac lesions to magnesium deficiency consequent to malnutrition and increased cardiac levels of cerium derived from monazite soils in the coastal regions of the tropics. We tested the hypothesis that the stimulus for fibroblast proliferation and enhanced collagen synthesis in EMF is derived from cardiac endothelial cells activated or injured by cerium...
2006: Biological Trace Element Research
Anne Kousa, Aki S Havulinna, Elena Moltchanova, Olli Taskinen, Maria Nikkarinen, Johan Eriksson, Marjatta Karvonen
Several epidemiologic studies have shown an association between calcium and magnesium and coronary heart disease mortality and morbidity. In this small-area study, we examined the relationship between acute myocardial infarction (AMI) risk and content of Ca, Mg, and chromium in local groundwater in Finnish rural areas using Bayesian modeling and geospatial data aggregated into 10 km times symbol 10 km grid cells. Data on 14,495 men 35-74 years of age with their first AMI in the years 1983, 1988, or 1993 were pooled...
May 2006: Environmental Health Perspectives
A Solini, P Zamboni, A Passaro, R Fellin, E Ferrannini
Alterations in electrolyte balance have been claimed to play a role in the pathophysiology of coronary heart disease; however, the relationship between the electrolyte pattern and other clinical variables immediately after an acute vascular event is unclear. The aim of the present study was to test whether electrolyte and microelement changes characterize the acute phase in patients with different degrees of glucose tolerance admitted to the hospital shortly after an acute cardiovascular or cerebrovascular ischemic event...
March 2006: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Chun-Yuh Yang, Chih-Ching Chang, Shang-Shyue Tsai, Hui-Fen Chiu
Many studies have examined the association between cardiovascular disease mortality and water hardness. However, the results have not been consistent. This report examines whether calcium and magnesium in drinking water are protective against acute myocardial infarction (AMI). All eligible AMI deaths (10,094 cases) of Taiwan residents from 1994 to 2003 were compared with deaths from other causes (10,094 controls), and the levels of calcium and magnesium in drinking water of these residents were determined. Data on calcium and magnesium levels in drinking water throughout Taiwan have been obtained from the Taiwan Water Supply Corporation...
July 2006: Environmental Research
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