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https://www.readbyqxmd.com/read/28531826/how-many-familial-hypercholesterolemia-patients-are-eligible-for-pcsk9-inhibition
#1
Luis Masana, Nuria Plana, Sofia Pérez-Calahorra, Daiana Ibarretxe, Itziar Lamiquiz-Moneo, Juan Pedro-Botet, Manuel Suárez-Tembra, Pedro Valdivielso, Emilio Ortega, Fernando Civeira
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a high cardiovascular risk condition. Less than 20% of patients achieve the LDL targets. Although PCSK9 inhibitors improve control and reduce cardiovascular events, official recommendations for their use are restrictive. We aim to assess the number of FH patients suitable for PCSK9 inhibition according to the European guidelines. METHODS: A total of 2685 FH patients, with a minimum follow-up of 6 months, included in the Dyslipidemia Registry of the Spanish Arteriosclerosis Society, were sorted according to the intensity of their lipid-lowering therapy (LLT) and LDL cholesterol levels achieved...
May 12, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28513324/biomechanical-comparison-of-countermovement-jumps-performed-on-land-and-in-water-age-effects
#2
Talin Louder, Dennis Dolny, Eadric Bressel
CONTEXT: The aquatic environment provides a low impact alternative to land-based exercise and rehabilitation in older adults. OBJECTIVE: Evaluate the biomechanics of older adults and young adults performing jumping movements on land and in water. DESIGN AND SETTING: Cross-sectional, mixed-factorial experiment; adjustable-depth pool at sports medicine research facility. PARTICIPANTS: Fifty-six young adults (22.0±3.9years) and twelve healthy older adults (57...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28502520/-exploring-the-diaphragm-ultrasound-is-essential
#3
REVIEW
P Richard
The diaphragm is the muscle most implicated in breathing. Its morphological exploration usually depends on pulmonary radiography, fluoroscopy, CT-scanning and MRI. Its function is evaluated by the classical respiratory functional tests, the measurement of maximum inspiratory and expiratory pressures, the transdiaphragmatic pressure and even an electromyogram. Ultrasound is a technique still insufficiently used in respiratory medicine. It offers, however, many advantages: it is easy to implement, there is no irradiation, it is usable at the bedside, particularly when the patient is immobile or in intensive care...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28493608/the-epidemiology-of-emergency-department-trauma-discharges-in-the-united-states
#4
Charles J DiMaggio, Jacob B Avraham, David C Lee, Spiros G Frangos, Stephen P Wall
OBJECTIVE: Injury related morbidity and mortality is an important emergency medicine and public health challenge in the United States (US). Here we describe the epidemiology of traumatic injury presenting to US emergency departments, define changes in types and causes of injury among the elderly and the young, characterize the role of trauma centers and teaching hospitals in providing emergency trauma care, and estimate the overall economic burden of treating such injuries. METHODS: We conducted a secondary retrospective, repeated cross-sectional study of the Nationwide Emergency Department Data Sample (NEDS), the largest all-payer emergency department survey database in the US...
May 11, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28493287/soft-tissue-sarcoma-nomograms-and-their-incorporation-into-practice
#5
REVIEW
Dario Callegaro, Rosalba Miceli, Luigi Mariani, Chandrajit P Raut, Alessandro Gronchi
The accurate prediction of prognosis in patients with soft tissue sarcoma (STS) is a challenging issue. Extreme variability in the clinical and pathological characteristics of this family of tumors hinders the simple stratification of patients into meaningful prognostic cohorts. Precision medicine tools for the prediction of prognosis, such as nomograms, enable personalized computation of outcome based on clinical and pathological characteristics of both patient and tumor. The eighth edition of the American Joint Committee on Cancer staging manual moved from a "population-based" to a "personalized" approach endorsing high-quality nomograms to improve clinician prediction ability in definite patient subgroups...
May 10, 2017: Cancer
https://www.readbyqxmd.com/read/28491193/indium-111-labeled-leukocyte-accumulation-in-extremity-soft-tissue-sarcoma
#6
Victor Fong, Lester Johnson
Nuclear medicine labeled leukocyte whole-body scintigraphy is commonly used to identify a source of infection in a patient with fever of unknown origin. White blood cells can also localize to other sites of inflammation, including sometimes tumors. A patient with a large myxofibrosarcoma in his left forearm was scanned due to chronic low-grade fever and persistent leukocytosis. This case demonstrates focal white blood cell activity in an extremity soft tissue sarcoma.
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28489466/intrathecal-injection-of-gadobutrol-a-tale-of-caution
#7
Corey Reeves, Enrique Galang, Raj Padalia, Nam Tran, Devang Padalia
In the field of interventional pain medicine a radiocontrast agent is commonly used in conjunction with fluoroscopy. Limited work has been published regarding the use of gadolium based contrast agents (GBCA) in the intrathecal space. We report a case of an intrathecal gadobutrol injection resulting in neurotoxic manifestations.A 60-year-old female with a history significant for lumbar post-laminectomy syndrome and intrathecal drug delivery implantation was admitted for lumbar fusion and kyphoplasty. Postoperatively, the patient had escalating pain medication requirements...
May 10, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28486279/payor-reform-opportunities-for-spine-surgery-part-i-background-and-stimulus-for-bundled-payments
#8
Jason Scalise, David Jacofsky
Spine surgery, and orthopedic surgery overall, is being increasingly scrutinized by payors due to large projected increases in utilization. The unsustainability of the fee-for-service payment system has lead payors to investigate novel value and risk-based contracting strategies on an episode of care basis and on a population health basis. These forays into progressive models for spine surgery have been supported by the successes demonstrated by advanced payor reform programs from The Centers for Medicare and Medicaid Services in other areas of musculoskeletal medicine...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28483694/controlling-nucleation-and-growth-of-nano-caco3-via-co2-sequestration-by-a-calcium-alkoxide-solution-to-produce-nanocomposites-for-drug-delivery-applications
#9
N G Martin Palmqvist, Jean-Marie Nedelec, Gulaim A Seisenbaeva, Vadim G Kessler
Calcium carbonate is an extremely attractive material in a plethora of biomedical applications. Intensive efforts have recently been made to achieve the control over its nucleation and subsequent aggregation, growth and crystallization; focusing on bringing insight into the role of precursors, solvents and templates. Having analyzed the recently acquired knowledge, we addressed this challenge using CO2 sequestration synthesis, using an unusual reactant, a solution of calcium ethoxide, Ca(OC2H5)2, as precursor...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28482859/an-ethnopharmacological-evaluation-of-navapind-and-shahpur-virkanin-district-sheikupura-pakistan-for-their-herbal-medicines
#10
Maria Zahoor, Zubaida Yousaf, Tahreem Aqsa, Manahil Haroon, Nadia Saleh, Arusa Aftab, Sadia Javed, Mouzma Qadeer, Habiba Ramazan
BACKGROUND: The chief aim of this study was to enlist the ethnobotanical uses of wild plants in district Sheikhupura, province Punjab, Pakistan. Due to extreme geographical and climatic conditions, Pakistan has a great floral diversity. Plants have been used by the indigenous people for treatment of different ailments since long. They are still dependent on the plants for their domestic purposes. Moreover, plants are used as first aid to treat diverse ailments such as cold, cough, influenza, asthma, cancer, antidote, gastric and hepatic disorders...
May 8, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28482596/surface-roughness-in-action-cells-in-opposition
#11
P Slepička, I Michaljaničová, S Rimpelová, V Švorčík
Aim of this work is to study the interaction of krypton fluoride (KrF) excimer laser beam with a biopolymer and creation of new nanostructures with great potential for cell growth guidance. As a substrate we used biocompatible and biodegradable polymer polyhydroxybutyrate, which is frequently used in medicine and drug delivery system. Modification was carried out by KrF laser and method was also supplemented by treatment with Ar(+) plasma. The changes in physico-chemical properties of surface layer were determined by goniometry, gravimetry and X-ray photoelectron spectroscopy (XPS)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28475810/draft-genome-sequence-of-the-tibetan-medicinal-herb-rhodiola-crenulata
#12
Yuanyuan Fu, Liangwei Li, Shijie Hao, Rui Guan, Guangyi Fan, Chengcheng Shi, Haibo Wan, Wenbin Chen, He Zhang, Guocheng Liu, Jihua Wang, Lulin Ma, Jianling You, Xuemei Ni, Zhen Yue, Xun Xu, Xiao Sun, Xin Liu, Simon Ming-Yuen Lee
Background: Rhodiola crenulata , a well-known medicinal Tibetan herb, is mainly grown in high-altitude regions of Tibet, Yunnan and Sichuan provinces in China. In the past few years increasing numbers of studies have been published on the potential pharmacological activities of R. crenulata , strengthening our understanding into its putitive active ingredient composition, pharmacological activity and mechanism of action. These findings also provide strong evidence supporting the important medicinal and economical value of R...
May 5, 2017: GigaScience
https://www.readbyqxmd.com/read/28474132/what-type-of-food-can-older-adults-masticate-evaluation-of-mastication-performance-using-color-changeable-chewing-gum
#13
Shinichi Wada, Nobuyuki Kawate, Masazumi Mizuma
This study determines if older adults can masticate regular foods via a simple test conducted using a color-changeable chewing gum. Seventy-nine consecutive inpatients of our clinic receiving rehabilitation and general medicine were assessed for eligibility. The inclusion criterion was >65 years. Thirty patients consented to participate. The main outcome variable was the food bolus texture at the swallowing threshold for five regular foods. The main explanatory variable was the a* value of the color-changeable chewing gum after 120 s of chewing (a* represents the degree of color between red and green, and a positive a* value indicates red)...
May 4, 2017: Dysphagia
https://www.readbyqxmd.com/read/28473462/reliability-of-a-scoring-system-used-for-qualitative-evaluation-of-lymphoscintigraphic-imaging-of-lower-extremities
#14
Mojgan Ebrahim, Irina Savitcheva, Rimma Axelsson
Introduction: Lymphoscintigraphy is an imaging technique to diagnose and characterize the severity of edema in upper and lower extremities. In lymphoscintigraphy a scoring system can increase ability of diagnostic differentiation but the use of any scoring system requires sufficient reliability. AIM: To determine inter- and intraobserver reliability of a proposed scoring system used for visual interpretation of lymphoscintigraphic imaging of lower extremities. Materials and Methods: Lymphoscintigrams in 81 persons were randomly selected from our database for retrospective evaluation...
May 4, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28472771/setbp1-dysregulation-in-congenital-disorders-and-myeloid-neoplasms
#15
REVIEW
Nicoletta Coccaro, Giuseppina Tota, Antonella Zagaria, Luisa Anelli, Giorgina Specchia, Francesco Albano
Myeloid malignancies are characterized by an extreme molecular heterogeneity, and many efforts have been made in the past decades to clarify the mechanisms underlying their pathogenesis.In this scenario SET binding protein 1 (SETBP1) has attracted a lot of interest as a new oncogene and potential marker, in addition to its involvement in the Schinzel-Giedon syndrome (SGS). Our review starts with the analysis of the structural characteristics of SETBP1, and extends to its corresponding physiological and pathological functions...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28470952/coping-with-missing-data-in-phase-iii-pivotal-registration-trials-tolvaptan-in-subjects-with-kidney-disease-a-case-study
#16
John Ouyang, Kevin J Carroll, Gary Koch, Junfang Li
Missing data cause challenging issues, particularly in phase III registration trials, as highlighted by the European Medicines Agency (EMA) and the US National Research Council. We explore, as a case study, how the issues from missing data were tackled in a double-blind phase III trial in subjects with autosomal dominant polycystic kidney disease. A total of 1445 subjects were randomized in a 2:1 ratio to receive active treatment (tolvaptan), or placebo. The primary outcome, the rate of change in total kidney volume, favored tolvaptan (P < ...
May 4, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28466050/emerging-threats-of-begomoviruses-to-the-cultivation-of-medicinal-and-aromatic-crops-and-their-management-strategies
#17
REVIEW
Sana Tabanda Saeed, Abdul Samad
Begomoviruses (family Geminiviridae) are responsible for extreme yield reduction in a number of economically important crops including medicinal and aromatic plants (MAPs). Emergence of new variants of viruses due to recombination and mutations in the genomes, modern cropping systems, introduction of susceptible plant varieties, global trade in agricultural products, and changes in climatic conditions are responsible for aggravating the begomovirus problems during the last two decades. This review summaries the current research work on begomoviruses affecting MAPs and provides various traditional and advanced strategies for the management of begomoviruses and vector in MAPs...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28464172/initial-experience-of-a-primary-urgent-care-clinic-curriculum-and-subspecialty-lectureship-series-implementation-in-a-los-angeles-county-hospital
#18
Harsh Agrawal, Anna Martinez, Elizabeth R Volkmann, Oleg Melamed, Soma Wali
OBJECTIVES: Urgent care clinics are extremely busy in the University of California-Los Angeles (UCLA) County hospital system. We determined that residents and medical students in the internal medicine residency program who are rotating through these clinics did not receive enough teaching during their rotation. We decided to create and implement an urgent care curriculum and lectures to help achieve structure for the rotation. The goal of this series was to educate and assist residents in the primary care setting to comfortably manage subspecialty conditions, help reduce the already-overwhelmed county subspecialty referral system, and promote learning...
May 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28460792/mentorship-in-radiology
#19
Danielle E Kostrubiak, Matt Kwon, Jiyon Lee, Jonathan A Flug, Jason C Hoffmann, Mariam Moshiri, Michael N Patlas, Douglas S Katz
Mentoring is an extremely important component of academic medicine, including radiology, yet it is not specifically emphasized in radiology training, and many academic radiology departments in the United States, Canada, and elsewhere do not have formal mentoring programs for medical students, residents, fellows, or junior faculty. The purpose of this article is to overview the current status of mentorship in radiology, to discuss the importance of mentorship at multiple levels and its potential benefits in particular, as well as how to conduct a successful mentor-mentee relationship...
February 20, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28459904/planning-and-designing-the-improving-addiction-care-team-impact-for-hospitalized-adults-with-substance-use-disorder
#20
Honora Englander, Melissa Weimer, Rachel Solotaroff, Christina Nicolaidis, Benjamin Chan, Christine Velez, Alison Noice, Tim Hartnett, Ed Blackburn, Pen Barnes, P. Todd Korthuis
People with substance use disorders (SUD) have high rates of hospitalization and readmission, long lengths of stay, and skyrocketing healthcare costs. Yet, models for improving care are extremely limited. We performed a needs assessment and then convened academic and community partners, including a hospital, community SUD organizations, and Medicaid accountable care organizations, to design a care model for medically complex hospitalized patients with SUD. Needs assessment showed that 58% to 67% of participants who reported active substance use said they were interested in cutting back or quitting...
May 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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