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https://www.readbyqxmd.com/read/27912956/further-comments-on-some-core-arguments-from-a-discussion-about-is-traditional-chinese-medicine-really-relevant
#1
Xiao Ye
A discussion on "Is traditional Chinese medicine (TCM) really relevant?" was held in the University College London (UCL) on the afternoon of 31st March, 2015. The author summarized some core viewpoints of the participants and then tried to focus on the opponent's opinions to clear up the arguments by illustrating respects of history, knowledge learning process, evidence based medicine (EBM) and strengths of TCM. This article will propose that the human health is extremely delicate and complicated and that no system of medicine can resolve all the problems of the human body...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27908220/pluripotent-stem-cells-the-last-10-years
#2
Erin A Kimbrel, Robert Lanza
Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches for disease modeling and drug development. Induced PSCs have become the foremost alternative to embryonic stem cells and accelerated the development of disease-in-a-dish models. Over the years and with each new discovery, PSCs have proven to be extremely versatile...
December 2, 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27905261/beneath-the-sword-of-damocles-regenerative-medicine-and-the-shadow-of-immunogenicity
#3
Paul J Fairchild, Christopher Horton, Priyoshi Lahiri, Kumaran Shanmugarajah, Timothy J Davies
Few topics in regenerative medicine have inspired such impassioned debate as the immunogenicity of cell types and tissues differentiated from pluripotent stem cells. While early predictions suggested that tissues derived from allogeneic sources may evade immune surveillance altogether, the pendulum has since swung to the opposite extreme, with reports that the ectopic expression of a few developmental antigens may prompt rejection, even of tissues differentiated from autologous cell lines. Here we review the evidence on which these contradictory claims are based in order to reach an objective assessment of the likely magnitude of the immunological challenges ahead...
December 1, 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27904797/preseason-jump-and-hop-measures-in-male-collegiate-basketball-players-an-epidemiologic-report
#4
Jason Brumitt, Amy Engilis, Dale Isaak, Amy Briggs, Alma Mattocks
BACKGROUND: Injuries are inherent in basketball with lower extremity (LE) injury rates reported as high as 11.6 per 1000 athletic exposures (AEs); many of these injuries result in time loss from sport participation. A recent trend in sports medicine research has been the attempt to identify athletes who may be at risk for injury based on measures of preseason fitness. HYPOTHESIS/PURPOSE: The purpose of this prospective cohort study was to determine if the standing long jump (SLJ) and/or the single-leg hop (SLH) for distance functional performance tests (FPT) are associated with non-contact time loss lower quadrant (LQ, defined as lower extremities or low back) injury in collegiate male basketball players...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27901647/a-decade-of-age-related-macular-degeneration-risk-models-what-have-we-learned-from-them-and-where-are-we-going
#5
Michael Zhang, Paul N Baird
The genomic revolution has revealed the complexity of multifactorial diseases, making the development of effective diagnostics extremely challenging. In turn, the prospect of precision medicine as applied through targeted therapeutic treatments continues to remain largely elusive. Age-related macular degeneration (AMD) as a complex disease falls under this category, despite it being one of the most well characterized multifactorial diseases. This reflects both the extent of identified genetic components and known environmental risk factors...
November 30, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27901560/medical-devices-physical-medicine-devices-classification-of-the-upper-extremity-prosthesis-including-a-simultaneously-powered-elbow-and-or-shoulder-with-greater-than-two-simultaneous-powered-degrees-of-freedom-and-controlled-by-non-implanted-electrical-components
#6
(no author information available yet)
The Food and Drug Administration (FDA) is classifying the Upper Extremity Prosthesis Including a Simultaneously Powered Elbow and/or Shoulder with Greater Than Two Simultaneous Powered Degrees of Freedom and Controlled by Non-Implanted Electrical Components into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the upper extremity prosthesis including a simultaneously powered elbow and/or shoulder with greater than two simultaneous powered degrees of freedom and controlled by non-implanted electrical components' classification...
October 18, 2016: Federal Register
https://www.readbyqxmd.com/read/27896995/muse-a-multi-locus-sampling-based-epistasis-algorithm-for-quantitative-genetic-trait-prediction
#7
Dan He, Laxmi Parida
Quantitative genetic trait prediction based on high-density genotyping arrays plays an important role for plant and animal breeding, as well as genetic epidemiology such as complex diseases. The prediction can be very helpful to develop breeding strategies and is crucial to translate the findings in genetics to precision medicine. Epistasis, the phenomena where the SNPs interact with each other, has been studied extensively in Genome Wide Association Studies (GWAS) but received relatively less attention for quantitative genetic trait prediction...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27892444/mortality-patterns-among-hospital-deaths
#8
R K Karki
Background Death occurring in hospital is medically certified by attending physicians with cause of death. In developing countries such as Nepal, limited resources are available related to the pattern of deaths that occur in hospitals, so that the health priorities can be selected wisely. Objective The objective of this study was to determine the pattern, frequency and causes of inpatient mortality in hospital. Method This was a retrospective study of all deaths occurred at the Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel from 1st January 2012 to 31st December 2013...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27890779/fast-triple-spin-echo-dixon-ftsed-sequence-for-water-and-fat-imaging
#9
R Korinek, K Bartusek, Z Starcuk
A number of 'Dixon' techniques based on fast spin echo (FSE) sequence have been proposed and successfully used in many branches of medicine. Some require only one scan, but most of them need multiple scans and long scan times. This article describes a new fast triple-spin-echo Dixon (FTSED) technique suitable for ultra-high field MRI, in which three specific time shifts are introduced in the echo train; thus, three images with defined water-fat phase-differences (0, π, 2π) are encoded in the phase of the acquired images without extreme restrictions upon the echo duration...
November 24, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27885803/rapid-and-sensitive-determination-of-phytosterols-in-functional-foods-and-medicinal-herbs-by-using-uhplc-ms-ms-with-microwave-assisted-derivatization-combined-with-dual-ultrasound-assisted-dispersive-liquid-liquid-microextraction
#10
Jing Sun, Xian-En Zhao, Jun Dang, Xiaoyan Sun, Longfang Zheng, Jinmao You, Xiao Wang
In this work, a hyphenated technique of dual ultrasound-assisted dispersive liquid-liquid microextraction combined with microwave-assisted derivatization followed by ultra high performance liquid chromatography tandem mass spectrometry has been developed for the determination of phytosterols in functional foods and medicinal herbs. Multiple reaction monitoring mode was used for the tandem mass spectrometry detection. A mass-spectrometry-sensitive reagent, 4'-carboxy-substituted rosamine, has been used as the derivatization reagent for five phytosterols, and internal standard diosgenin was used for the first time...
November 25, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27882745/-comparison-of-perinatal-mortality-in-slovak-republic-in-the-years-2007-2009-and-in-the-years-2010-2012
#11
M Korbeľ, A Krištúfková, M Borovský, J Danko, Z Nižňanská, P Kaščák, J Daniš
OBJECTIVE: Comparison of perinatal mortality in Slovak Republic in the years 2007-2009 and in the years 2010-2012. DESIGN: Epidemiological perinatal nation-wide. SETTING: 1st Department of Gynaecology and Obstetrics School of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic. METHODS: The analysis of selected perinatal data prospectively collected in the years 2007-2009 and in the years 2010-2012...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27878794/varicosities-of-the-lower-extremity-new-approaches-cosmetic-or-therapeutic-needs
#12
Luca Spinedi, Heiko Uthoff, Sasan Partovi, Daniel Staub
Varicose veins of the lower extremity (VVLE) are a frequently encountered vascular disorder in the general population. The general view that VVLE are a non-serious disease with primarily aesthetic impact is a common misconception, as the disease can have a significant negative impact on generic and disease-specific quality of life. Further, VVLE may be associated with potentially threatening clinical conditions, such as chronic venous ulceration, venous thromboembolism and haemorrhage from ruptured varicose veins...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27876115/the-first-digit-law-a-hypothesis-on-its-possible-impact-on-medicine-and-development-aid
#13
Gregor Pollach, Frank Brunkhorst, Mwapatsa Mipando, Felix Namboya, Samson Mndolo, Thomas Luiz
The "first digit law" or "Benford's law" is a mathematical distribution discovered by Simon Newcomb and Frank Benford. It states, that the probability of the leading number d (d∈{1,…,9}) in many natural datasets follows: P (d)=log10 (d+1)-log10 (d)=log10 (1+1/d). It was successfully used through tax authorities and "forensic accounting" in order to detect fraud and other irregularities. Benfords law was almost neglected for its use outside financial accounting. The planning for health care systems in developing countries is extremely dependant on good, valid data...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27873183/interdisciplinary-oncology-education-a-national-survey-of-trainees-and-program-directors-in-the-united-states
#14
Adil S Akthar, Christopher D Hellekson, Sabha Ganai, Olwen M Hahn, Ronald J Maggiore, Ezra E Cohen, Mitchell C Posner, Steven J Chmura, Andrew R Howard, Daniel W Golden
Oncologists must have a strong understanding of collaborating specialties in order to deliver optimal cancer care. The objective of this study was to quantify current interdisciplinary oncology education among oncology training programs across the USA, identify effective teaching modalities, and assess communication skills training. Web-based surveys were sent to oncology trainees and program directors (PDs) across the USA on April 1, 2013 and October 8, 2013, respectively. Question responses were Yes/No, five-point Likert scales (1 = not at all, 2 = somewhat, 3 = moderately, 4 = quite, 5 = extremely), or free response...
November 21, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27871101/morphomics-of-the-talus
#15
David Gorman, Ebram Handy, Sikui Wang, Annette L Irwin, Stewart Wang
Previous studies of frontal crash databases reported that ankle fractures are among the most common lower extremity fractures. While not generally life threatening, these injuries can be debilitating. Laboratory research into the mechanisms of ankle fractures has linked dorsiflexion with an increased risk of tibia and fibula malleolus fractures. However, talus fractures were not produced in the laboratory tests and appear to be caused by more complex loading of the joint. In this study, an analysis of the National Automotive Sampling System - Crashworthiness Data System (NASS-CDS) for the years 2004-2013 was conducted to investigate foot-ankle injury rates in front seat occupants involved in frontal impact crashes...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27868449/establishing-the-turkish-version-of-the-sigam-mobility-scale-and-determining-its-validity-and-reliability-in-lower-extremity-amputees
#16
Hülya Yilmaz, Ümit Gafuroğlu, Nicola Ryall, Selcen Yüksel
PURPOSE: The aim of this study is to adapt the Special Interest Group in Amputee Medicine (SIGAM) mobility scale to Turkish, and to test its validity and reliability in lower extremity amputees. MATERIAL AND METHODS: Adaptation of the scale into Turkish was performed by following the steps in American Association of Orthopedic Surgeons (AAOS) guideline. Turkish version of the scale was tested twice on 109 patients who had lower extremity amputations, at hours 0 and 72...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27860546/transcatheter-aortic-valve-replacement-state-of-the-art-and-future-directions
#17
Mackram F Eleid, David R Holmes
Transcatheter aortic valve replacement (TAVR) is a transformational and rapidly evolving treatment for patients with aortic stenosis who require valve replacement. Novel technological advancements have made this percutaneous minimally invasive therapy a first-line treatment for many patients at extreme risk for conventional cardiac surgery. New devices and improvements in existing devices have reduced procedural complications, and scientific trials are investigating the role of TAVR in lower-risk aortic stenosis populations, in patients with aortic regurgitation, and in patients with bicuspid aortic valve disease...
November 14, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27849442/to-genotype-or-phenotype-for-personalized-medicine-cyp450-drug-metabolizing-enzyme-genotype-phenotype-concordance-and-discordance-in-the-ecuadorian-population
#18
Fernando De Andrés, Santiago Terán, Francisco Hernández, Enrique Terán, Adrián LLerena
Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing enzymes confer substantial person-to-person and between-population differences in pharmacokinetics, and by extension, highly variable clinical effects of medicines. In this context, "personalized medicine," "precision medicine," and "stratified medicine" are related concepts attributed to what is essentially targeted therapeutics and companion diagnostics, aimed at improving safety and effectiveness of health interventions...
November 16, 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27849322/the-effect-of-body-mass-index-on-trauma-severity-and-prognosis-in-trauma-patients
#19
Hasan Mansur Durgun, Recep Dursun, Yılmaz Zengin, Ayhan Özhasenekler, Murat Orak, Mehmet Üstündağ, Cahfer Güloğlu
BACKGROUND: As in the rest of the world, the prevalence of obesity in Turkey has been increasing in recent years and has become a major public health issue. Although many trials have been conducted to study the effects of obesity on internal diseases, there are few studies investigating the effects of obesity on prognosis of trauma patients. The present study analyzed the effects of body mass index (BMI) on trauma severity and prognosis in trauma patients. METHODS: This study was prospectively conducted with trauma patients older than 15 years of age who presented at the Dicle University Faculty of Medicine emergency medicine department trauma unit between June 1, 2013 and May 31, 2014...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27846232/allium-sativum-protease-inhibitor-a-novel-kunitz-trypsin-inhibitor-from-garlic-is-a-new-comrade-of-the-serpin-family
#20
Tooba Naz Shamsi, Romana Parveen, Mohd Amir, Mohd Affan Baig, M Irfan Qureshi, Sher Ali, Sadaf Fatima
PURPOSE: This study was aimed to purify and characterize the Protease inhibitor (PI) from a plant Allium sativum (garlic) with strong medicinal properties and to explore its phytodrug potentials. METHODS: Allium sativum Protease Inhibitor (ASPI) was purified using ammonium sulphate fractionation and Fast Protein Liquid Chromatography on anion exchanger Hi-Trap DEAE column. The purified protein was analyzed for its purity and molecular weight by SDS PAGE. The confirmation of presence of trypsin inhibiting PI was performed by MALDI TOF-TOF and analyzed by MASCOT database...
2016: PloS One
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