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https://www.readbyqxmd.com/read/29211888/combined-oral-contraception-and-bicalutamide-in-polycystic-ovary-syndrome-and-severe-hirsutism-a-double-blind-rtc
#1
Costanzo Moretti, Laura Guccione, Paola Di Giacinto, Ilaria Simonelli, Caterina Exacoustos, Vincenzo Toscano, Cecilia Motta, Vincenzo De Leo, Felice Petraglia, Andrea Lenzi
Background: Hirsutism is frequently expressed in women affected by polycystic ovary syndrome (PCOS). The efficacy of oral contraceptive pill (OC) plus anti-androgens in the treatment of its severe expression is controversial due to the lack of randomized double-blind long-term studies. Aim: The primary outcome was the reduction of hirsutism in PCOS women objectively measured by videodermoscopy (VD) on the androgen-sensitive skin areas assessed by the modified Ferriman&Gallwey (mF&G) total score, after 12 months of therapy with OC+Bicalutamide (BC) versus OC plus placebo (P)...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29209864/pharmacists-and-prescribers-neonatal-abstinence-syndrome-nas-prevention-behaviors-a-preliminary-analysis
#2
Nicholas E Hagemeier, Ivy A Click, Heather Flippin, Holly Gilliam, Alexandra Ross, Jeri Ann Basden, Ronald Carico
Background Maternal opioid use and neonatal abstinence syndrome (NAS) incidence have increased markedly in the US in recent years. Objectives (1) To assess prescribers' and community pharmacists' guideline-based NAS prevention behaviors; (2) to describe providers' perceptions of contraceptive appropriateness in female patients of childbearing age. Method Cross-sectional study of 100 randomly selected primary care physicians, 100 prescribers authorized to engage in in-office treatment of opioid use disorders with buprenorphine, 100 pain management clinic directors, and 100 community pharmacists in Tennessee (N = 400 providers total) to evaluate self-reported engagement in 15 NAS prevention behaviors and perceived appropriateness of 8 contraceptive methods in opioid using women of childbearing age...
December 5, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29202210/differential-effects-on-haemostatic-markers-by-metformin-and-the-contraceptive-pill-a-randomized-comparative-trial-in-pcos
#3
Genia F Burchall, Terrence J Piva, Sanjeeva Ranasinha, Helena J Teede
Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objective To investigate and compare haemostatic impacts of common pharmacological treatments and explore relationships with hormonal and metabolic variables in PCOS. Patients/Methods This mechanistic sub-study using biobanked samples from a 6-month randomized comparative trial of pharmacological treatments assessed pro- and anti-thrombotic markers and overall haemostatic activity...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29201413/high-risk-sexual-behaviors-while-on-depot-medroxyprogesterone-acetate-as-compared-to-oral-contraception
#4
Deborah Bartz, Rie Maurer, Jessica Kremen, Jennifer M Fortin, Elizabeth Janiak, Alisa B Goldberg
Background: Depot medroxyprogesterone acetate (DMPA) contraceptive use is associated with an increased risk for Chlamydia infection. However, prior studies inadequately account for potential differences in sexual behavior between users of DMPA and users of other contraceptive methods. In this study we compare sexual risk-taking behavior in women using DMPA to women using oral contraceptive pills (OCP) to assess risk of Chlamydia trachomatis infection. Methods: In this cross-sectional study of 630 reproductive-aged women seeking routine gynecologic care (449 OCP and 181 DMPA users) sexual risk-taking was evaluated by use of the Safe Sex Behavior Questionnaire, a validated measure of sexual behaviors and attitudes...
2017: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29198974/low-acceptability-of-certain-contraceptive-methods-among-young-women
#5
Andrea J Hoopes, Stephanie Teal, Aletha Y Akers, Jeanelle Sheeder
OBJECTIVE: To examine what predicts low personal acceptability of four different contraceptive methods among young women. DESIGN: Cross-sectional survey SETTING: Urban adolescent contraception clinic in Colorado PARTICIPANTS: Female clinic patients ages 13-24 initiating contraception from 8/2011-4/2012 METHODS: Survey participants reported their personal acceptability for oral contraceptive pills (OCPs), depot medroxyprogesterone (DMPA), contraceptive implants, and intrauterine devices (IUD) on a scale from 0 (low) to 10 (high)...
November 30, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29194043/the-role-of-corticosteroid-binding-globulin-in-the-evaluation-of-adrenal-insufficiency
#6
REVIEW
Kate C Verbeeten, Alexandra H Ahmet
Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation. In the assessment of adrenal insufficiency, many clinicians measure a total serum cortisol level, which assumes that CBG is present in normal concentrations and with a normal binding affinity for cortisol. CBG concentration and affinity are affected by a number of common factors including oral contraceptive pills (OCPs), fever and infection, as well as rare mutations in the serine protease inhibitor A6 (SERPINA6) gene, and as such, total cortisol levels might not be the ideal way to assess adrenal function in all clinical circumstances...
December 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29180907/clinical-behavior-of-a-cohort-of-adult-women-with-facial-acne-treated-with-combined-oral-contraceptive-ethinylestradiol-20-%C3%A2%C2%B5g-dienogest-2-mg
#7
John Palacio-Cardona, Diana María Caicedo Borrero
Acne vulgaris is the most common skin disease. It affects the young adult female population and generates great impact on physical and mental health. One of the treatments with good results for affected women is combined oral contraceptive pills (COCPs). The aim of this study was to determine the clinical effect of facial acne management with ethinylestradiol 20 µg/dienogest 2 mg in a cohort of Colombian adult women. A cohort of 120 female university students was followed for 12 months. These participants were enrolled in the Sexual and Reproductive Health Program of the Santiago de Cali University...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29180385/treatment-of-venous-thromboembolism-in-a-22-year-old-woman-taking-an-oral-contraceptive-pill
#8
Daniel M Shafran, Cynthia Wu
No abstract text is available yet for this article.
November 27, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29176540/the-effect-of-oral-contraceptive-pills-on-the-macula-the-retinal-nerve-fiber-layer-and-choroidal-thickness
#9
Yusuf Madendag, Gokhan Acmaz, Mustafa Atas, Erdem Sahin, Ahter Tanay Tayyar, Ilknur Çol Madendag, Fatma Özdemir, Vesile Senol
BACKGROUND The aim of this study was to evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), and choroidal thickness (CT). MATERIAL AND METHODS A total of 24 healthy women taking monophasic OCP (3 mg drospirenone and 0.03 mg ethinylestradiol) for contraception only for at least one year were compared with a control group of 24 healthy women who were not taking an OCP. Optical coherence tomography (OCT) was used to evaluate the posterior ocular segments, and measurements were taken in the follicular phase (day 3) of the cycle in all women...
November 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29172411/contraception-update-oral-contraception
#10
Elizabeth J Brown, Prium Deshmukh, Karen Antell
The oral contraceptive pill (OCP) is the most commonly used form of reversible contraception. The two types of OCPs are combination oral contraceptives (COCs), which contain estrogen and progesterone, and progestin-only pills (POPs). Both have failure rates of approximately 7.2% to 9% with typical use, and are safe for most patients. Because estrogen-containing contraceptives can increase the risk of venous thromboembolism, patients with conditions associated with a risk of cardiovascular events should not use COCs...
November 2017: FP Essentials
https://www.readbyqxmd.com/read/29166843/stagnant-contraceptive-sales-after-the-zika-epidemic-in-brazil
#11
Luis Bahamondes, Moazzam Ali, Ilza Monteiro, Arlete Fernandes
OBJECTIVES: Our aim was to assess national hormonal and non-hormonal contraceptive sales in Brazil after the Zika virus outbreak. METHODS: Pharmaceutical companies based in Brazil provided data on monthly sales from September 2016 to June 2017. Data from both the public and private sectors were obtained about sales of registered, available modern contraceptive methods: combined oral contraceptive pill; progestin-only pill; vaginal and transdermal contraceptives; injectable contraceptives; long-acting reversible contraceptive (LARC) methods, including the copper-releasing intrauterine device, the levonorgestrel-releasing intrauterine system and the etonogestrel-releasing subdermal implant; and emergency contraceptive pills...
November 23, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29165926/contraception-of-potions-pills-and-social-change
#12
Jacqueline Berry, Boon H Lim
No abstract text is available yet for this article.
December 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29159927/hormonal-contraceptive-use-and-vitamin-a-deficiency-among-women-in-tanzania
#13
Zelalem T Haile, Asli K Teweldeberhan, Bhakti Chavan, John Francescon
OBJECTIVE: To examine the association between hormonal contraceptive use and vitamin A deficiency among women in Tanzania. METHODS: Secondary analysis of data from 8231 women who participated in the 2010 Tanzania Demographic and Health Survey. Both descriptive and inferential statistical analyses were performed. RESULTS: Overall, 1291 (weight percentage 17.8%) women reported a history of hormonal contraceptive use. The weighted prevalence of vitamin A deficiency was 36...
November 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29159891/the-experience-of-sexuality-in-adults-with-intellectual-disability
#14
M D Gil-Llario, V Morell-Mengual, R Ballester-Arnal, I Díaz-Rodríguez
BACKGROUND: People with intellectual disability have the same sexual needs as those without any disability, yet their sexuality is often restricted by reluctant attitudes and/or fears based on irrational beliefs. The aim of this study is to describe and analyse different areas of sexuality in adults with mild or moderate intellectual disability. METHOD: The sample consisted of 180 men and 180 women attending occupational centres. All the participants were administered a questionnaire about sexuality adapted to their characteristics...
November 20, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29156452/an-international-consortium-update-pathophysiology-diagnosis-and-treatment-of-polycystic-ovarian-syndrome-in-adolescence
#15
Lourdes Ibáñez, Sharon E Oberfield, Selma F Witchel, Richard J Auchus, R Jeffrey Chang, Ethel Codner, Preeti Dabadghao, Feyza Darendeliler, Nancy Samir Elbarbary, Alessandra Gambineri, Cecilia Garcia Rudaz, Kathleen M Hoeger, Abel López-Bermejo, Ken Ong, Alexia S Peña, Thomas Reinehr, Nicola Santoro, Manuel Tena-Sempere, Rachel Tao, Bulent O Yildiz, Haya Alkhayyat, Asma Deeb, Dipesalema Joel, Reiko Horikawa, Francis de Zegher, Peter A Lee
This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels...
November 13, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29146297/pregnancy-intention-and-contraceptive-use-among-women-by-class-of-obesity-results-from-the-2006-2010-and-2011-2013-national-survey-of-family-growth
#16
Brian T Nguyen, Jennifer L Elia, Cathrine Y Ha, Bliss E Kaneshiro
OBJECTIVE: Conflicting research findings on the association of obesity and pregnancy intention may be due to their collective definition of obesity at a body mass index of 30 kg/m(2) or greater. However, obese women with a BMI of 40 kg/m(2) or greater may be both behaviorally and clinically different from obese women with a lower BMI. This study reexamines this relationship, stratifying by class of obesity; the study also explores variations in contraceptive use by class of obesity given their potential contribution to the incidence of unintended or unwanted pregnancy...
November 13, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29141040/medical-therapy-versus-radiofrequency-endometrial-ablation-in-the-initial-treatment-of-heavy-menstrual-bleeding-itom-trial-a-clinical-and-economic-analysis
#17
Abimbola O Famuyide, Shannon K Laughlin-Tommaso, Sherif A Shazly, Kirsten Hall Long, Daniel M Breitkopf, Amy L Weaver, Michaela E McGree, Sherif A El-Nashar, Maureen A Lemens, Matthew R Hopkins
BACKGROUND: Radiofrequency endometrial ablation (REA) is currently a second line treatment in women with heavy menstrual bleeding (MHB) if medical therapy (MTP) is contraindicated or unsatisfactory. Our objective is to compare the effectiveness and cost burden of MTP and REA in the initial treatment of HMB. METHODS: We performed a randomized trial at Mayo Clinic Rochester, Minnesota. The planned sample size was 60 patients per arm. A total of 67 women with HMB were randomly allocated to receive oral contraceptive pills (Nordette ®) or Naproxen (Naprosyn®) (n = 33) or REA (n = 34)...
2017: PloS One
https://www.readbyqxmd.com/read/29137944/reproductive-factors-nutritional-status-and-serum-25-oh-d-levels-in-women-with-breast-cancer-a-case-control-study
#18
REVIEW
Nighat Y Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy R, Chander P Yadav, Ravindra M Pandey, Neha Sareen
The study was conducted with an objective to investigate the association between reproductive factors, nutritional status and serum 25(OH)D levels among women diagnosed with breast cancer (BC). A total of 200 women with BC attending a tertiary healthcare institute of Delhi, India matched with 200 healthy women for age (±2years) and socio economic status were included in the study. Data was collected on socio-demographic profile, reproductive factors, physical activity and dietary intake (24h dietary recall and food frequency questionnaire) using interviewer administered structured questionnaires and standard tools...
November 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29136172/assessing-the-contraceptive-supply-environment-in-kinshasa-drc-trend-data-from-pma2020
#19
S Babazadeh, S Lea, P Kayembe, P Akilimali, L Eitmann, P Anglewicz, J Bertrand
Performance Monitoring and Accountability 2020 (PMA2020) is a population-based and facility-based survey program conducted in 11 countries to track contraceptive use dynamics and the supply environment. Annual data collection provides trend data unavailable from any other source. Two-stage cluster sampling was used to select 58 enumeration areas in Kinshasa; data were collected in 2014, 2015 and 2016 from three to six service delivery points (SDPs) per EA. Of the 228-248 SDPs surveyed each year, only two-thirds reported to offer family planning (FP) services...
November 10, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29131489/evaluation-of-the-serum-zinc-level-in-adult-patients-with-melasma-is-there-a-relationship-with-serum-zinc-deficiency-and-melasma
#20
Majid Rostami Mogaddam, Nastaran Safavi Ardabili, Manouchehr Iranparvar Alamdari, Nasrollah Maleki, Maryam Aghabalaei Danesh
BACKGROUND: Melasma is a common acquired hypermelanosis of sun-exposed skin, particularly on the face, which presents as symmetric, light- to gray-brown-colored macules and patches. There are several studies of serum zinc levels in cutaneous disorders. So far, no studies have been carried out to assess the serum zinc level in patients with melasma. The aim of this study is to determine the serum zinc level in patients with melasma compared to healthy subjects. MATERIALS AND METHODS: A total of 118 patients with melasma and 118 healthy controls were enrolled in this prospective cross-sectional study...
November 12, 2017: Journal of Cosmetic Dermatology
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