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https://www.readbyqxmd.com/read/28730840/the-safety-of-available-and-emerging-options-for-emergency-contraception
#1
Jessica K Lee, Eleanor Bimla Schwarz
Emergency contraception (EC) is a way to significantly reduce the chance of becoming pregnant after an episode of unprotected intercourse. Considerable data support the safety of all available and emerging options for EC. Areas covered: This review presents a comprehensive summary of the literature regarding the safety of EC as well as directions for further study. PubMed was searched for all relevant studies published prior to June 2017. Expert Opinion: All available methods of EC (i.e., ulipristal acetate pills, levonorgestrel pills, and the copper-IUD), carry only mild side effects and serious adverse events are essentially unknown...
July 21, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28721311/from-kaua-i-to-hawai-i-island-interisland-differences-in-emergency-contraceptive-pill-availability
#2
Holly Bullock, Mary Tschann, Jennifer Elia, Bliss Kaneshiro, Jennifer Salcedo
Emergency contraceptive pills (ECPs) are medications used after unprotected intercourse, underprotected intercourse, or sexual assault to decrease the risk of pregnancy. Availability of ECPs in Hawai'i's retail pharmacies was last assessed in 2007, following over-the-counter access to levonorgestrel ECPs (LNG-ECP) for women age 18 years or older and prior to U.S. Food and Drug Administration (FDA) approval of prescription-only ulipristal acetate (UPA). We conducted a county-by-county subanalysis from a larger observational population-based study on statewide availability of ECPs in Hawai'i's pharmacies...
July 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28715852/treatment-of-premenstrual-dysphoria-with-continuous-versus-intermittent-dosing-of-oral-contraceptives-results-of-a-three-arm-randomized-controlled-trial
#3
Tory A Eisenlohr-Moul, Susan S Girdler, Jacqueline L Johnson, Peter J Schmidt, David R Rubinow
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomized controlled trials (RCTs) indicate that oral contraceptives administered with a shortened or eliminated hormone-free interval are superior to placebo. However, results of such trials are mixed, and no existing studies have directly compared continuous and intermittent dosing schedules of the same oral contraceptive...
July 17, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28715060/the-complex-interaction-between-polycystic-ovary-syndrome-and-hereditary-angioedema-case-reports-and-review-of-the-literature
#4
Marina Iahn-Aun, Marcelo Vivolo Aun, Antonio Abílio Motta, Jorge Kalil, Pedro Giavina-Bianchi, Sylvia Asaka Hayashida, Edmund Chada Baracat, Gustavo Arantes Maciel
Importance: Hereditary angioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen levels. Polycystic ovary syndrome (PCOS) is a common hyperandrogenic condition, which is frequently treated with combined oral contraceptives. Objective: The aim of this study was to describe 2 clinical cases of young women diagnosed as having PCOS who developed HAE attacks after the introduction of combined estrogen-progestin pills to treat PCOS symptoms...
July 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28713532/bilateral-cavernous-sinus-thrombosis-as-first-manifestation-of-primary-burkitt-lymphoma-of-the-thyroid-gland
#5
Mehdi Moghaddasi, Mona Nabovvati, Saeed Razmeh
Cavernous sinus thrombosis (CST) is a rare condition that is usually associated with infections, pregnancy, vasculitis and some types of medication, such as the contraceptive pill and paraneoplastic. Primary Burkitt lymphoma (PBL) of the thyroid gland is very uncommon and the clinical description of such cases has been largely limited to case reports. In this paper, we present a case of CST as the first manifestation of PBL of the thyroid gland. To the best of our knowledge, our patient is the first case report of PBL of the thyroid gland that presents with bilateral CST...
June 23, 2017: Neurology International
https://www.readbyqxmd.com/read/28712125/oral-contraceptive-pill-alters-acute-dietary-protein-induced-thermogenesis-in-young-women
#6
Maharani Retna Duhita, Yves Schutz, Jean-Pierre Montani, Abdul G Dulloo, Jennifer L Miles-Chan
OBJECTIVE: There is much interest in the role of dietary protein for weight control. However, there remains a need to characterize individual determinants of the thermogenic effects of protein. This study aimed to investigate the influence of menstrual cycle phase and the combined, monophasic oral contraceptive pill on the thermogenic response to a standardized high-protein (HP) versus normal-protein (NP) meal. METHODS: Following an overnight fast, resting energy expenditure (EE) was measured in 16 healthy young women (8 taking and 8 not taking the pill) and 8 men for 30 minutes pre ingestion and 3 hours post ingestion of a NP (11%) or HP (24%) meal...
July 16, 2017: Obesity
https://www.readbyqxmd.com/read/28710636/biotransformation-of-dhea-into-7%C3%AE-15%C3%AE-dioh-dhea
#7
Hui Li, Jin Sun, Zhenghong Xu
3β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive "Yasmin" (widely used in birth control pills and postmenopausal hormone replacement therapy pills; the active ingredient is drospirenone). It can be synthesized from dehydroepiandrosterone (DHEA) by microbial dihydroxylation at the C7 and C15 positions. Here we describe the method of bioconversion from DHEA into 7α,15α-diOH-DHEA by Colletotrichum lini. Using 6 g/L DHEA as a substrate, the DHEA conversion and the 7α,15α-diOH-DHEA molar yield were 72...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28706368/knowledge-and-behaviour-regarding-birth-prevention-of-healthcare-providers
#8
Smriti Bhargava, Nupur Hooja, Rajani Nawal, Bhomraj Kumawat, Avantika Sharma, Richa Manish
INTRODUCTION: Healthcare providers are an important link with the general public to impart knowledge regarding contraception. They are an important source of providing information regarding different methods of contraception, their proper use and removing the myths from the couple's mind. However, their own attitude and practice of contraception are often lacking. OBJECTIVE: This study was conducted to assess the attitude and practice of contraception over the last 1 year of nurses in a tertiary care hospital in Jaipur...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28694152/drug-interactions-between-non-rifamycin-antibiotics-and-hormonal-contraception-a-systematic-review
#9
REVIEW
Katharine B Simmons, Lisa B Haddad, Kavita Nanda, Kathryn M Curtis
OBJECTIVE: To determine whether interactions between non-rifamycin antibiotics and hormonal contraceptives result in decreased effectiveness or increased toxicity of either therapy. DATA SOURCES: We searched MEDLINE, Embase, clinicaltrials.gov and Cochrane libraries from database inception through June, 2016. STUDY ELIGIBILITY CRITERIA: We included trials, cohort, case-control, and pharmacokinetic (PK) studies in any language addressing pregnancy rates, pharmacodynamics or PK outcomes when any hormonal contraceptive and non-rifamycin antibiotic were administered together versus apart...
July 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28688030/from-pill-to-condom-or-nothing-at-all-hiv-diagnosis-and-discontinuation-of-highly-effective-contraceptives-among-women-in-northeast-brazil
#10
Bianca M Stifani, Sarah MacCarthy, Amy Nunn, Nerys Benfield, Inês Dourado
This is a cross-sectional study examining highly effective contraceptive (HEC) use among HIV-positive women in Salvador, Brazil. We used multivariate logistic regression to look for predictors of alternative contraceptive choices among women who discontinued HEC after HIV diagnosis. Of 914 participants surveyed, 38.5% of participants used HEC before but not after diagnosis. Of these, 65.9% used condoms alone; 19.3% used no protection; and 14.8% reported abstinence. Use of condoms alone was associated with a history of other sexually transmitted infections (AOR 2...
July 7, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28676529/combined-contraceptive-pill-and-long-term-cancer-risk
#11
(no author information available yet)
No abstract text is available yet for this article.
July 4, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28676251/the-not-so-bitter-pill-effects-of-combined-oral-contraceptives-on-peripheral-physiological-indicators-of-emotional-reactivity
#12
Diana Armbruster, Clemens Kirschbaum, Alexander Strobel
Combined oral contraceptives (COC) are used by millions of women worldwide. Although findings are not entirely consistent, COC have been found to impact on brain function and, thus, to modulate affective processes. Here, we investigated electro-physiological responses to emotional stimuli in free cycling women in both the early follicular and late luteal phase as well as in COC users. Skin conductance response (SCR), startle reflex, corrugator and zygomaticus activity were assessed. COC users showed reduced overall startle magnitude and SCR amplitude, but heightened overall zygomaticus activity, although effect sizes were small...
July 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28664322/identification-and-characterization-of-the-steroid-15%C3%AE-hydroxylase-gene-from-penicillium-raistrickii
#13
Longgang Jia, Jianzhang Dong, Ruijie Wang, Shuhong Mao, Fuping Lu, Suren Singh, Zhengxiang Wang, Xiaoguang Liu
Penicillium raistrickii ATCC 10490 is used for the commercial preparation of 15α-13-methy-estr-4-ene-3,17-dione, a key intermediate in the synthesis of gestodene, which is a major component of third-generation contraceptive pills. Although it was previously shown that a cytochrome P450 enzyme in P. raistrickii is involved in steroid 15α-hydroxylation, the gene encoding the steroid 15α-hydroxylase remained unknown. In this study, we report the cloning and characterization of the 15α-hydroxylase gene from P...
June 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28663249/quick-starting-hormonal-contraception-after-using-oral-emergency-contraception-a-systematic-review
#14
REVIEW
Lauren Ee Murphy, Zhong E Chen, Valerie Warner, Sharon T Cameron
INTRODUCTION: Unprotected intercourse after oral emergency contraception (EC) significantly increases pregnancy risk. This underlies the importance of promptly starting effective, ongoing contraception - known as 'quick starting'. However, theoretical concern exists that quick starting might interact with EC or hormonal contraception (HC) potentially causing adverse side effects. METHOD: A systematic review was conducted, evaluating quick starting HC after oral EC [levonorgestrel 1...
June 29, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28642961/female-sexual-dysfunction-with-combined-oral-contraceptive-use
#15
Jean Jasmin M L Lee, Thiam Chye Tan, Seng Bin Ang
Combined oral contraceptive pills (COCs) remain one of the most popular forms of contraception to prevent unwanted pregnancy in women. While it is known that COCs can cause sexual dysfunction in women, there is currently no recommendation to screen for sexual function before and after initiation of COCs. We propose that, based on the evidence available, assessment of sexual function should be done at initiation of COCs, as well as at regular intervals thereafter. This would allow COC-related sexual dysfunction to be managed early, such as by switching the patient to newer-generation COCs or other forms of contraception...
June 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28639461/hormonal-contraception-and-breast-cancer-what-more-do-we-need-to-know
#16
Jo Marsden
Most women use hormonal contraception for more than 30 years and for many, this may involve exposure in their older reproductive years when baseline breast cancer risk rises steeply. Overall, the risk of breast cancer diagnosis with exposure to hormonal contraception is very small and outweighed by its contraceptive benefits but despite this, there are still outstanding questions for all methods used in clinical practice due to paucity of available evidence, lack of which should not be taken to imply safety...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28639423/emergency-contraceptive-pill-users-risk-perceptions-for-sexually-transmitted-infections-and-future-unintended-pregnancy
#17
Mary T Hickey, Michele G Shedlin
BACKGROUND AND PURPOSE: The availability of emergency contraception pills (ECP) over the counter (OTC) has the potential to reduce the incidence of unintended pregnancy; however, the increased risk for sexually transmitted infection (STI) acquisition, related to unprotected intercourse, has not been adequately addressed. The purpose of this study is to gain insight into risk perceptions for STIs and subsequent unintended pregnancy in women who have purchased ECP OTC. METHODS: Twenty-one women, aged 18-24, attending a private university in an urban setting, who purchased and used ECP OTC participated in 1-h, individual interviews...
June 22, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28638292/combined-oral-contraceptive-pill-initiation-in-a-patient-with-major-depressive-disorder-premenstrual-dysphoric-disorder-social-anxiety-panic-disorder-and-histrionic-personality-disorder
#18
Cody Roi, Erich J Conrad
BACKGROUND: Comorbid psychiatric conditions present an added layer of challenge in managing patients, as each condition and associated set of symptoms exacerbate the complexity of the overall presentation. Premenopausal women may be at particular risk for inadequate care, as their comorbid conditions may present overlapping symptoms and mask independent premenstrual symptoms. The prevalence of premenstrual dysphoric disorder and associated conditions can be as high as 8% in women of reproductive age...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28618247/contraception-what-about-the-men-experience-knowledge-and-attitudes-a-survey-of-2438-heterosexual-men-using-an-online-dating-service
#19
Mary Stewart, Todd Ritter, Deborah Bateson, Kevin McGeechan, Edith Weisberg
Background: There is little research on men's contraceptive knowledge, attitudes and beliefs, yet the male partner is known to influence contraceptive choices. This study investigates contraceptive experiences, knowledge, attitudes and beliefs of a sample of sexually active, heterosexual men via an online dating site. Methods: An anonymous online survey was sent to men who had logged onto an online dating site within the previous year. Results: We analysed 2438 survey responses. A contraceptive method was used at last intercourse for 82% of men <50 years old versus 69% of men ≥50 (P<0...
June 16, 2017: Sexual Health
https://www.readbyqxmd.com/read/28608970/effect-of-extended-oral-contraception-use-on-the-prevalence-of-fetal-trisomy-21-in-women-aged-at-least-35-years
#20
Dániel Horányi, Lilla Éva Babay, János Rigó, Balázs Győrffy, Gyula R Nagy
OBJECTIVE: To study factors influencing the number of ovulations in reproductive life as risk factors for common trisomies. METHODS: The present observational study examined data from genetic counseling sessions performed at the 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary, between September 1, 2013, and September 1, 2015, and retrieved data on patients of advanced maternal age (≥35 years) who had fetal trisomy 21, 18, or 13 confirmed...
June 13, 2017: International Journal of Gynaecology and Obstetrics
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