keyword
MENU ▼
Read by QxMD icon Read
search

Peripheral nerve

keyword
https://www.readbyqxmd.com/read/29232108/biocompatible-electroactive-tetra-aniline-conjugated-peptide-nanofibers-for-neural-differentiation
#1
Idil Arioz, Ozlem Erol, Gokhan Bakan, F Begum Dikecoglu, Ahmet Emin Topal, Mustafa Urel, Aykutlu Dana, Ayse B Tekinay, Mustafa O Guler
Peripheral nerve injuries cause devastating problems for the quality of the patients' lives and regeneration following a damage to the peripheral nervous system is limited depending on the degree of the damage. Use of nanobiomaterials can provide therapeutic approaches for the treatment of peripheral nerve injuries. Electroactive biomaterials, in particular, can provide a promising cure for the regeneration of nerve defects. Here, a supramolecular electroactive nanosystem with tetra(aniline) (TA) containing peptide nanofibers was developed and utilized for nerve regeneration...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29230526/peripheral-nerve-diffusion-tensor-imaging-dti-normal-values-and-demographic-determinants-in-a-cohort-of-60-healthy-individuals
#2
Moritz Kronlage, Véronique Schwehr, Daniel Schwarz, Tim Godel, Lorenz Uhlmann, Sabine Heiland, Martin Bendszus, Philipp Bäumer
OBJECTIVE: To identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). METHODS: Sixty subjects were examined at 3 Tesla by single-shot DTI. FA, AD, RD, and MD were collected for the sciatic, tibial, median, ulnar, and radial nerve and were correlated with demographic variables. RESULTS: Mean FA of all nerves declined with increasing age (r = -0...
December 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29230099/the-effect-of-co-transplantation-of-nerve-fibroblasts-and-schwann-cells-on-peripheral-nerve-repair
#3
Yang Wang, Dong Li, Gangyang Wang, Lulu Chen, Jun Chen, Zhangyin Liu, Zhaofeng Zhang, Hua Shen, Yuqing Jin, Zunli Shen
Combinations of fibroblasts (Fbs) and corresponding epithelial cells have been widely used in many tissues, such as the skin and breast tissues, to augment tissue repair and remodeling. Recently, a large amount of new data has indicated that nerve Fbs play critical roles in Schwann cells (SCs) and axons in vitro. However, little is known regarding the effects of co-transplanting nerve Fbs and SCs on peripheral nerve repair in vivo. The aim of this study was to investigate the effect of co-transplanting sciatic nerve Fbs (SN-Fbs) and sciatic nerve SCs (SN-SCs) on nerve regeneration...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29229552/caspase-6-is-a-dispensable-enabler-of-adult-mammalian-axonal-degeneration
#4
V Woo, C Cheng, A Duraikannu, A Chandrasekhar, K Purdy, J A Martinez, D W Zochodne
The progress of axonal degeneration (AxD) following injury or insult impacts both recovery from axonal transection and protection of axons from diverse insults, or axonopathy. Here we provide evidence that increases in capase-6 (Casp6) expression and action contribute to the progression of AxD. The expression of Casp6 protein and mRNA in distal branches of sensory axons undergoing AxD was confirmed. We developed and utilized a new model of axonopathy in live mice by serially visualizing the viability of cutaneous axons in the ear pinna that expressed an axonal YFP transgene, in response to capasaicin-induced AxD...
December 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29227106/hollow-silica-nanoparticles-penetrate-the-peripheral-nerve-and-enhance-the-nerve-blockade-from-tetrodotoxin
#5
Qian Liu, Claudia M Santamaria, Tuo Wei, Chao Zhao, Tianjiao Ji, Tianshe Yang, Andre Shomorony, Bruce Y Wang, Daniel S Kohane
The efficacy of tetrodotoxin (TTX), a very potent local anesthetic, is limited by its poor penetration through barriers to axonal surfaces. To address this issue, we encapsulated TTX in hollow silica nanoparticles (TTX-HSN) and injected them at the sciatic nerve in rats. TTX-HSN achieved an increased frequency of successful blocks, prolonged the duration of the block, and decreased the toxicity compared to free TTX. In animals injected with fluorescently labeled HSN, the imaging of frozen sections of nerve demonstrated that HSN could penetrate into nerve and that the penetrating ability of silica nanoparticles was highly size-dependent...
December 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/29224922/neurons-and-satellite-glial-cells-in-adult-rat-lumbar-dorsal-root-ganglia-express-connexin-36
#6
E Martha Pérez Armendariz, Monica Norcini, Beatriz Hernández-Tellez, Andrés Castell-Rodríguez, Cristina Coronel-Cruz, Raquel Guerrero Alquicira, Alexandra Sideris, Esperanza Recio-Pinto
Previous studies have shown that following peripheral nerve injury there was a downregulation of the gap junction protein connexin 36 (Cx36) in the spinal cord; however, it is not known whether Cx36 protein is expressed in the dorsal root ganglia (DRGs), nor if its levels are altered following peripheral nerve injuries. Here we address these aspects in the adult rat lumbar DRG. Cx36 mRNA was detected using qRT-PCR, and Cx36 protein was identified in DRG sections using immunohistochemistry (IHC) and immunofluorescence (IF)...
December 7, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29223703/the-foreign-body-response-and-morphometric-changes-associated-with-mesh-style-peripheral-nerve-cuffs
#7
Michael B Christensen, Patrick A Tresco
Nerve cuffs have been used to anchor and protect penetrating electrodes in peripheral nerves and have been used as non-penetrating electrodes for neural recording and nerve stimulation. The material of choice for such applications is silicone, an inert synthetic biomaterial which elicits a minimal chronic foreign body response (FBR). While histological studies of solid silicone cuffs are available, to the best of our knowledge a comparison to other cuff designs is not well documented. Here, we describe the FBR and morphological changes that accompany nerve cuff implantation in the rat sciatic nerve by comparing a metallic mesh with and without a parylene coating to one made of silicone...
December 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29223350/%C3%AE-6-and-%C3%AE-1-integrin-heterodimer-mediates-schwann-cell-interactions-with-axons-and-facilitates-axonal-regeneration-after-peripheral-nerve-injury
#8
In Ae Chang, Ki Joong Kim, Uk Namgung
Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sciatic nerve after a crush injury, and the blocking of integrin activity by siRNA expression and by treatment with anti-integrin antibodies attenuates Schwann cell contact with cultured neurons and decreases neurite outgrowth...
December 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/29223072/alteration-of-autophagy-related-proteins-in-peripheral-blood-mononuclear-cells-of-patients-with-parkinson-s-disease
#9
Yasuo Miki, Shuji Shimoyama, Tomoya Kon, Tatsuya Ueno, Ryo Hayakari, Kunikazu Tanji, Tomoh Matsumiya, Eiki Tsushima, Fumiaki Mori, Koichi Wakabayashi, Masahiko Tomiyama
Previous postmortem studies demonstrated dysregulation of autophagy in patients with Parkinson's disease (PD). To clarify whether this alteration reflects a fundamental aspect of PD or represents the final stage of autophagy dysregulation resulting from a long neurodegenerative process, we focused on basal autophagy in peripheral blood mononuclear cells (PBMCs) of PD patients (n = 35) and controls (n = 23). The whole-transcriptome assay revealed downregulation of mRNAs for 6 core regulators of autophagy (UNC-51-like kinase [ULK] 3, autophagy-related [Atg] 2A, Atg4B, Atg5, Atg16L1, and histone deacetylase 6)...
November 21, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29222932/a-fibers-mediate-cold-hyperalgesia-in-patients-with-oxaliplatin-induced-neuropathy
#10
Julia Forstenpointner, Violetta C Oberlojer, Dennis Naleschinski, Johanna Höper, Stephanie M Helfert, Andreas Binder, Janne Gierthmühlen, Ralf Baron
Cold hyperalgesia is a common side effect of oxaliplatin treatment; still the pathophysiological and molecular mechanisms as well as the contribution of different primary afferent fiber systems are unclear. Therefore, patients with oxaliplatin-induced acute neuropathy with (n=6) and without (n=7) cold hyperalgesia were tested by applying a preferential blockade of peripheral myelinated A-fiber afferents in combination with quantitative sensory testing. Additionally, an interview-based questionnaire assessed the severity of symptoms and the impact on daily activities...
December 9, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222774/preparation-of-adult-rat-sensory-neuron-cultures-and-their-application-to-growth-cone-turning-assays
#11
Christine A Webber, Douglas W Zochodne
The directional trajectory of growing peripheral nerve axons in the adult impacts their successful regeneration to denervated target tissues. Misdirected axons in neuromas, injured nerve trunks, or nerves with attempted repair diminish the success of regeneration. The behavior of adult rodent peripheral sensory neurons in vitro, in turn, is helpful in predicting axonal behavior in vivo. Here, we describe the adaptation of embryonic neuron growth cone turning assays, an important technique in developmental neurobiology, to adult rat sensory neurons...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29221815/corneal-confocal-microscopy-as-a-non-invasive-test-to-assess-diabetic-peripheral-neuropathy
#12
Qian Xiong, Bin Lu, Hong-Ying Ye, Si-Ying Liu, Hang-Ping Zheng, Rui-Yun Zhang, Xiao-Na Qiao, Shuo Zhang, Xiao-Xia Liu, Qing-Chun Li, Na Yi, Liang-Cheng Wu, Jie Wen, Tian-Song Zhang, Yi-Ming Li
OBJECTIVE: To evaluate the efficacy of corneal confocal microscopy (CCM)as a non-invasive test to assess diabetic peripheral neuropathy in Chinese patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Diabetic distal symmetric polyneuropathy (DSPN) and its severity degrees were assessed based on the modified Toronto diagnostic criteria in 128 patients with type 2 diabetes (No DSPN [n = 49], mild DSPN [n = 43], moderate-to-severe DSPN [n = 36]) and 24 age-matched controls...
December 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29221755/unilateral-brachial-plexopathy-a-rare-complication-of-mycoplasma-pneumoniae-infection
#13
Barbara Robnik, Darja Keše, Tereza Rojko, Alenka Horvat-Ledinek, Aleš Pražnikar, Bojana Beović
Few reports in the literature describe isolated peripheral neuropathies in relation to Mycoplasma pneumoniae infection without concurrent damage to the central nervous system. To our knowledge only a single case of mononeuritis multiplex with brachial plexus neuropathy coincident with M. pneumoniae has been documented until now. Here we present the first clinical case of lobar M. pneumoniae pneumonia in a 19-year-old female patient, where coincident neurological complications manifested as unilateral brachial plexus neuropathy, affecting axillar and suprascapular nerves...
December 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29220864/the-nature-of-catecholamine-containing-neurons-in-the-enteric-nervous-system-in-relationship-with-organogenesis-normal-human-anatomy-and-neurodegeneration
#14
G Natale, L Ryskalin, C L Busceti, F Biagioni, F Fornai
The gastrointestinal tract is provided with extrinsic and intrinsic innervation. The extrinsic innervation includes the classic vagal parasympathetic and sympathetic components, with afferent sensitive and efferent secretomotor fibers. The intrinsic innervations is represented by the enteric nervous system (ENS), which is recognized as a complex neural network controlling a variety of cell populations, including smooth muscle cells, mucosal secretory cells, endocrine cells, microvasculature, immune and inflammatory cells...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29220302/biology-and-management-of-undifferentiated-pleomorphic-sarcoma-myxofibrosarcoma-and-malignant-peripheral-nerve-sheath-tumors-state-of-the-art-and-perspectives
#15
Brigitte C Widemann, Antoine Italiano
Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218369/peripheral-nerve-ultrasound-findings-in-mucolipidosis-type-3
#16
Eoin Mulroy, Andrew M Chancellor, Luciana Pelosi
PURPOSE: The mucolipidoses are rare autosomal recessive lysosomal storage disorders. Neurologic involvement in these conditions is generally thought to be limited to cognitive delay and entrapment neuropathies (primarily carpal tunnel syndrome). We sought to evaluate peripheral nerves in this condition using nerve ultrasound. METHODS: We performed peripheral nerve ultrasound in two siblings with genetically confirmed mucolipidosis type 3 (alpha/beta). RESULTS: Peripheral nerves in mucolipidosis type 3 (alpha/beta) exhibit multifocal enlargement...
December 7, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29218119/carpal-tunnel-syndrome-and-other-entrapment-neuropathies
#17
REVIEW
Kolawole Wasiu Wahab, Emmanuel O Sanya, Philip B Adebayo, Musbaudeen O Babalola, Hakeem G Ibraheem
Entrapment neuropathy is the result of pressure on a peripheral nerve as it passes through a narrow canal that is bounded by stiff tissues. In spite of their ubiquitous nature, they are underdiagnosed, underreported, and sometimes not properly managed, especially in developing countries. Entrapment neuropathies are of various types, but the most common type is carpal tunnel syndrome. Mechanisms involved in the pathophysiology of entrapment neuropathies include mechanical compression and nerve ischemia. A clear understanding of the various types and the underlying mechanisms of entrapment neuropathies are invaluable in the decision-making process involved in the management of every patient with the condition...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29217679/miz1-controls-schwann-cell-proliferation-via-h3k36me2-demethylase-kdm8-to-prevent-peripheral-nerve-demyelination
#18
David Fuhrmann, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Hans-Peter Elsässer
Schwann cell differentiation and myelination depends on chromatin remodeling, histone acetylation and methylation, which all have impact on Schwann cell proliferation. We previously reported that the deletion of the POZ domain of the transcription factor Miz1 (encoded by Zbtb17) in mouse Schwann cells (Miz1ΔPOZ) causes a neuropathy at 90 days after birth (P90), with a subsequent spontaneous regeneration. Here we show that RNA sequencing from Miz1ΔPOZ and control animals at P30 revealed a set of upregulated genes with a strong correlation to cell cycle regulation...
December 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217500/peripheral-neuropathy-as-a-complication-of-diabetic-ketoacidosis-in-a-child-with-newly-diagnosed-diabetes-type-1-case-report
#19
Marta Baszyńska-Wilk, Marta Wysocka-Mincewicz, Anna Świercz, Jolanta Świderska, Magdalena Marszał, Mieczysław Szalecki
BACKGROUND: Neurological complications of diabetic ketoacidosis are considered to be very serious clinical problem. The most common complication is cerebral edema. However this group includes also less common syndromes such as ischemic or hemorrhagic stroke, cerebral venous and sinus thrombosis or very rare peripheral neuropathy. CASE REPORT: We present a case of 9-year old girl with new onset type 1 diabetes, diabetic ketoacidosis, cerebral edema, multifocal vasogenic brain lesions and lower limbs peripheral paresis...
December 8, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29217448/perioperative-outcomes-after-regional-versus-general-anesthesia-for-above-knee-amputations
#20
Andrew J B Pisansky, Ethan Y Brovman, Christine Kuo, Alan D Kaye, Richard D Urman
INTRODUCTION: Non-traumatic lower extremity amputation (LEA) remains a common procedure among patients who frequently have significant comorbidities. Patients undergoing above knee amputation (AKA) have the highest rates of mortality in this cohort, yet there is little evidence to support selection between peripheral nerve block or neuraxial regional anesthesia (RA) versus general anesthetic (GA) techniques. OBJECTIVE: To determine whether regional anesthesia (neuraxial or peripheral nerve block) techniques were associated with more favorable outcomes versus general anesthesia among patients undergoing AKA...
December 4, 2017: Annals of Vascular Surgery
keyword
keyword
11444
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"