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https://www.readbyqxmd.com/read/29045998/-plastic-reconstructive-microsurgery-in-the-elderly-patient-consensus-statement-of-the-german-speaking-working-group-for-microsurgery-of-the-peripheral-nerves-and-vessels
#1
Ingo Ludolph, Marcus Lehnhardt, Andreas Arkudas, Ulrich Kneser, Gerhard Pierer, Yves Harder, Raymund E Horch
During the last two decades, understanding and experience of microsurgical reconstruction have increased. This is linked to improved instruments and technical devices, as well as to the increased number of available donor sites for microvascular flap transfer. If the indication is appropriate, it is now possible to perform personalised, safe and successful microsurgical reconstructions, almost independently of the patients' age. Despite these constant developments, there is little specific literature on microsurgery related to the specific problems of the elderly patient...
October 18, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29044770/effects-of-forced-passive-and-voluntary-exercise-on-spinal-motoneurons-changes-after-peripheral-nerve-injury
#2
Ariadna Arbat-Plana, Xavier Navarro, Esther Udina
After peripheral nerve injury, there are important changes at the spinal level that can lead to disorganization of the central circuitry and thus, compromise functional recovery even if axons are able to successfully regenerate and reinnervate their target organs. Physical rehabilitation is a promising strategy to modulate these plastic changes and thus, to improve functional recovery after damage of the nervous system. Forced exercise in a treadmill is able to partially reverse the synaptic stripping and the loss of perineuronal nets that motoneurons suffer after peripheral nerve injury in animal models...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29044452/effects-of-alpha-lipoic-acid-on-motor-function-and-antioxidant-enzyme-activity-of-nerve-tissue-after-sciatic-nerve-crush-injury-in-rats
#3
Sarper Kocaoğlu, Özgür Aktaş, Oğuzhan Zengi, Azmi Tufan, Feyza Karagöz Güzey
AIM: Background: Alpha lipoic acid (ALA) that is a strong antioxidant drug is tried for both protection and treatment of various diseases of central and peripheral nervous systems. MATERIAL AND METHODS: Material and Methods: Protective effects of ALA on crush type peripheral nerve injury were evaluated. 28 Sprague-Dawley rats were divided into four groups: In Group 1, sciatic nerve was only explored. Sciatic nerve crush injury was performed after serum physiologic injection intraperitoneally in Group 2, and after ALA injection in Groups 3 and 4...
August 31, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29042416/nicotine-prevents-and-reverses-paclitaxel-induced-mechanical-allodynia-in-a-mouse-model-of-cipn
#4
S Lauren Kyte, Wisam Toma, Deniz Bagdas, Julie A Meade, Lesley D Schurman, Aron H Lichtman, Zhi-Jian Chen, Egidio Del Fabbro, Xianjun Fang, John W Bigbee, M Imad Damaj, David A Gewirtz
Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes CIPN in 59-78% of cancer patients. Novel interventions are needed due to the current lack of effective CIPN treatments. Our studies were designed to investigate if nicotine can prevent and/or reverse paclitaxel-induced peripheral neuropathy in a mouse model of CIPN, while ensuring that nicotine will not stimulate lung tumor cell proliferation or interfere with the anti-tumor properties of paclitaxel...
October 17, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29042309/the-binding-of-botulinum-neurotoxins-to-different-peripheral-neurons
#5
O Rossetto
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality. Despite the high affinity and the very specific binding, botulinum neurotoxins are versatile and multi-tasking toxins. Indeed they are able to act both at the somatic and at the autonomic nervous system. In spite of the preference for cholinergic nerve terminals botulinum neurotoxins have been shown to inhibit to some extent also the noradrenergic postganglionic sympathetic nerve terminals and the afferent nerve terminals of the sensory neurons inhibiting the release of neuropeptides and glutamate, which are responsible of nociception...
October 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29042158/predictive-value-of-metacarpophalangeal-stabilization-tests-for-simulated-ulnar-nerve-lesion-measured-by-a-sensor-glove
#6
Nikolaus Johannes Wachter, Martin Mentzel, Gert D Krischak, Joachim Gülke
STUDY DESIGN: A within-subject research design was used in this study. The difference of the range of motion (ROM) with and without ulnar nerve block was analyzed. INTRODUCTION: For the clinical evaluation of the functional effects of ulnar nerve palsy at the hand the relevance of clinical tests is in discussion. PURPOSE OF THE STUDY: The aim of the study was to evaluate the predictive value of 2 clinical tests for a simulated ulnar nerve lesion by motion analysis with a sensor glove...
October 14, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29042063/-pharmacokinetic-and-clinical-effects-of-two-bupivacaine-concentrations-on-axillary-brachial-plexus-block
#7
Leonardo H C Ferraro, Alexandre Takeda, Cleber N Barreto, Bernadete Faria, Nilson A Assunção
INTRODUCTION: The risk of systemic bupivacaine toxicity is a persistent problem, which makes its pharmacokinetic study fundamental for regional anesthesia safety. There is little evidence of its influence on plasma peak at different concentrations. The present study compares two bupivacaine concentrations to establish how the concentration affects this drug plasma peak in axillary brachial plexus block. Postoperative latency and analgesia were also compared. METHODS: 30 patients were randomized...
October 14, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29041999/electrodiagnostic-and-nerve-ultrasonographic-features-in-upper-limb-spasticity-an-observational-study
#8
A Picelli, S Tamburin, G Berto, E Chemello, Marialuisa Gandolfi, Leopold Saltuari, Andreas Waldner, Nicola Smania
To better understand the effects of spasticity on peripheral nerves, we evaluated the electrodiagnostic and nerve ultrasonographic features of the median and ulnar nerves in adults with upper limb spasticity. Twenty chronic stroke patients with spastic hemiparesis underwent nerve conduction study and nerve ultrasonography of the median and ulnar nerves at both upper limbs. Affected versus unaffected upper limb comparisons showed significant differences in the median and ulnar nerve distal motor latencies, compound muscle action potentials and F-wave minimal latencies...
July 2017: Functional Neurology
https://www.readbyqxmd.com/read/29038932/mr-t2-value-of-the-tibial-nerve-can-be-used-as-a-potential-non-invasive-and-quantitative-biomarker-for-the-diagnosis-of-diabetic-peripheral-neuropathy
#9
Dongye Wang, Chuan Wang, Xiaohui Duan, Zehong Yang, Zhiqiang Bai, Huijun Hu, Li Yan, Jun Shen
OBJECTIVE: To determine the role of quantitative tibial nerve T2 value in the diagnosis of diabetic peripheral neuropathy (DPN). METHODS: MR imaging and T2 mapping of the tibial nerve were performed in 22 diabetic patients with DPN, 20 diabetic patients without DPN and 20 healthy controls. Nerve T2 values were measured, and compared using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic ability of T2 value to identify DPN...
October 16, 2017: European Radiology
https://www.readbyqxmd.com/read/29036889/single-administration-of-melatonin-modulates-the-nitroxidergic-system-at-the-peripheral-level-and-reduces-thermal-nociceptive-hypersensitivity-in-neuropathic-rats
#10
Elisa Borsani, Barbara Buffoli, Veronica Bonazza, Russel J Reiter, Rita Rezzani, Luigi F Rodella
Neuropathic pain is a severe condition with unsatisfactory treatments. Melatonin, an indolamine, seems to be a promising molecule suitable for this purpose due to its well-known anti-inflammatory, analgesic, and antioxidant effects, as well as its modulation of the nitroxidergic system. Nevertheless, the data on its mechanism of action and potentialities are currently insufficient in this pathology, especially at the peripheral level. Thus, this work evaluated the effect of a single administration of melatonin in an established mononeuropathy pain model that monitors the behaviour and the changes in the nitroxidergic system in dorsal root ganglia and skin, which are affected by nervous impairment...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036728/a-retrospective-study-evaluating-the-effect-of-low-doses-of-perineural-dexamethasone-on-ropivacaine-brachial-plexus-peripheral-nerve-block-analgesic-duration
#11
Gregory D Schnepper, Benjamin I Kightlinger, Yunyun Jiang, Bethany J Wolf, Eric D Bolin, Sylvia H Wilson
Objective: Examination of the effectiveness of perineural dexamethasone administered in very low and low doses on ropivacaine brachial plexus block duration. Design: Retrospective evaluation of brachial plexus block duration in a large cohort of patients receiving peripheral nerve blocks with and without perineural dexamethasone in a prospectively collected quality assurance database. Setting: A single academic medical center. Methods: A total of 1,942 brachial plexus blocks placed over a 16-month period were reviewed...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036361/chronic-pain-and-neuropathy-following-adjuvant-chemotherapy
#12
Lise Ventzel, Caspar S Madsen, Páll Karlsson, Hatice Tankisi, Baris Isak, Anders Fuglsang-Frederiksen, Anders B Jensen, Anni R Jensen, Troels S Jensen, Nanna B Finnerup
Objective: To determine symptoms and characteristics of chronic sensory neuropathy in patients treated with oxaliplatin and docetaxel, including patterns of somatosensory abnormalities, pain descriptors, and psychological functioning. Design: A retrospective cross-sectional study. Setting: A chronic pain research center. Subjects: Thirty-eight patients with chronic peripheral pain and/or dysesthesia following chemotherapy...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036022/-important-details-in-performing-and-interpreting-the-scratch-collapse-test
#13
Lorna C Kahn, Andrew Yee, Susan E Mackinnon
The utility of the Scratch Collapse Test (SCT) has been demonstrated in examination of patients with carpal and cubital tunnel syndromes and long thoracic and peroneal nerve compressions. In our clinic, this lesser known test plays a key role in peripheral nerve examination where localization of the nerve irritation or injury is not fully understood. Test utility and accuracy in patients with more challenging presentations likely correlates with tester understanding and experience. This paper offers a clear outline of all stages of the test in order to improve inter-rater reliability...
October 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29035835/nerve-growth-factor-beta-purified-from-bull-seminal-plasma-enhances-corpus-luteum-formation-and-conceptus-development-in-bos-taurus-cows
#14
Jamie L Stewart, Vitor R G Mercadante, Nicholas W Dias, Igor F Canisso, Peter Yau, Brian Imai, Fabio S Lima
The objective of the current study was to determine if Nerve Growth Factor-Beta (NGF), purified from bovine seminal plasma, would improve corpus luteum function and enhance conceptus development when administered to cows at artificial insemination. Angus cows (n = 60) were synchronized using a GnRH-prostaglandin and intravaginal progesterone protocol (7-day CO-Synch/CIDR) and randomly allocated to 1 of 2 treatment groups: (1) CONT- 12 mL PBS; or (2) NGF- 296 μg purified NGF in 12 mL PBS administered intramuscularly at insemination (day 0)...
October 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29034645/peripheral-neuropathy-in-multiple-sclerosis-an-electrophysiologic-study-in-iranian-patients
#15
Mohammad Reza Emad, Leila Zeinali, Alireza Nikseresht, Mahshid Naseri, Hajar Karimian
Multiple sclerosis (MS) is the most common cause of disability after trauma in young adults in Northern Hemisphere; it imposes a major burden on the affected young people. A significant association between MS and demyelinating peripheral neuropathy which might be due to common pathogenesis for the central and peripheral nerves demyelination has been reported in several studies. We aimed to assess if there is any peripheral nervous system involvement in a sample of Iranian MS population. Extensive nerve conduction studies (NCS) were conducted in 20 MS patients according to McDonald criteria, and 20 age and gender matched healthy appearing controls...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034542/time-frequency-analysis-of-increases-in-vaginal-blood-perfusion-elicited-by-long-duration-pudendal-neuromodulation-in-anesthetized-rats
#16
Indie C Rice, Lauren L Zimmerman, Shani E Ross, Mitchell B Berger, Tim M Bruns
OBJECTIVES: Female sexual dysfunction (FSD) affects a significant portion of the population. Although treatment options for FSD are limited, neuromodulation for bladder dysfunction has improved sexual function in some women. A few studies have investigated peripheral neuromodulation for eliciting changes in vaginal blood flow, as a proxy for modulating genital sexual arousal, however results are generally transient. Our central hypothesis is that repeated or extended-duration pudendal nerve stimulation can elicit maintained vaginal blood flow increases...
October 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29033684/fluorine-18-2-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-masquerading-as-a-case-of-sporadic-malignant-peripheral-nerve-sheath-tumor-of-lower-extremity-presenting-as-massive-lower-limb-edema
#17
Deepa Singh, Rajender Kumar, Ashim Das, Subhash C Varma, Bhagwant R Mittal
Malignant peripheral nerve sheath tumors (MPNSTs) are rare neuroectodermal tumors resulting from the malignant transformation of benign plexiform neurofibromas. The sporadic form of these tumors is rare than familial variants (seen in neurofibromatosis Type 1) and making the diagnosis difficult. We are presenting a case of 40--year-old female with the complaint of progressive swelling of lower limb with initial suspicion of lymphedema and underwent lymphoscintigraphy, magnetic resonance imaging, and finally fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scans were done to rule out mitotic etiology and extent of the disease...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29032027/peripheral-neuropathy-and-hindlimb-paralysis-in-a-mouse-model-of-adipocyte-specific-knockout-of-lkb1
#18
Yan Xiong, Jessica C Page, Naagarajan Narayanan, Chao Wang, Zhihao Jia, Feng Yue, Xine Shi, Wen Jin, Keping Hu, Meng Deng, Riyi Shi, Tizhong Shan, Gongshe Yang, Shihuan Kuang
Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energy metabolism; and adipocyte-specific knockout of Lkb1 (Ad-Lkb1 KO) leads to the expansion of BAT, improvements in systemic metabolism and resistance to obesity in young mice. Here we report the unexpected finding that the Ad-Lkb1 KO mice develop hindlimb paralysis at mid-age...
September 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29031203/local-anaesthetic-pain-relief-therapy-in-vitro-and-in-vivo-evaluation-of-a-nanotechnological-formulation-co-loaded-with-ropivacaine-and-dexamethasone
#19
Yongxin Zhang, Yaocun Yue, Meng Chang
Combination therapy is frequently applied to anesthesia and analgesia for its benefits, which includes prolonged analgesia following peripheral nerve blockade, and reduced side effects. The aim of this study was to develop chitosan (CH) coated poly(ε-caprolactone) (PCL) nanoparticles to co-deliver ropivacaine (RPV) and dexamethasone (DEM) (RPV/DEM CH-PCL NPs) for the prolongation of anesthesia and pain relief. In the present study, RPV/DEM CH-PCL NPs were fabricated. The properties of CH-PCL NPs were evaluated for their particle sizes, zeta potential, drug loading capacity and in vitro drug release profile...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030589/aberrant-ocular-architecture-and-function-in-patients-with-klinefelter-syndrome
#20
Cristin Brand, Michael Zitzmann, Nicole Eter, Sabine Kliesch, Joachim Wistuba, Maged Alnawaiseh, Peter Heiduschka
Klinefelter Syndrome (KS), the most common chromosomal disorder in men (47,XXY), is associated with numerous comorbidities. Based on a number of isolated case reports, we performed the first systematic and comprehensive evaluation of eye health in KS patients with a focus on ocular structure and vascularization. Twenty-one KS patients and 26 male and 38 female controls underwent a variety of non-invasive examinations investigating ocular morphology (examination of retinal thickness, optic nerve head, and cornea) and function (visual field testing and quantification of ocular vessel density by optical coherence tomography angiography)...
October 13, 2017: Scientific Reports
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