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https://www.readbyqxmd.com/read/28087154/evaluation-of-serial-high-sensitivity-troponin-t-levels-in-individuals-without-overt-coronary-heart-disease-following-exercise-stress-testing
#1
Yousef M E Saad, Hanan Idris, Ibrahim M Shugman, Krishna K Kadappu, Rohan Rajaratnam, Liza Thomas, Christian Mussap, Dominic Y C Leung, Craig P Juergens, John K French
BACKGROUND: Detectable levels of high sensitivity (cardiac) troponin T (HsTnT), occur in the majority of patients with stable coronary heart disease (CHD), and often in 'healthy' individuals. Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels. However, whether HsTnT elevations occur commonly after exercise stress testing (EST), and if so, whether this has clinical significance, needs clarification. METHODS: To determine whether HsTnT levels become elevated after EST (Bruce protocol) to ≥95% of predicted maximum heart rate in presumed healthy subjects without overt CHD, we assayed HsTnT levels for ∼5h post-EST in 105 subjects (median age 37 years)...
December 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28073264/metal-organic-polyhedra-coated-si-nanowires-for-the-sensitive-detection-of-trace-explosives
#2
Anping Cao, Wei Zhu, Jin Shang, Johan H Klootwijk, Ernst J R Sudhölter, Jurriaan Huskens, Louis C P M de Smet
Surface-modified silicon nanowire-based field-effect transistors (SiNW-FETs) have proven to be a promising platform for molecular recognition in miniature sensors. In this work, we present a novel nanoFET device for the sensitive and selective detection of explosives based on affinity layers of metal-organic polyhedra (MOPs). The judicious selection of the geometric and electronic characteristics of the assembly units (organic ligands and unsaturated metal site) embedded within the MOP cage allowed for the formation of multiple charge-transfer (CT) interactions to facilitate the selective explosive inclusion...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28070907/analysis-of-explosives-by-gc-uv
#3
Jan Andrasko, Ludmila Lagesson-Andrasko, Johan Dahlén, Bengt-Harald Jonsson
A mixture of explosives was analyzed by gas chromatography (GC) linked to ultraviolet (UV) spectrophotometry that enabled detection in the range of 178-330 nm. The gas-phase UV spectra of 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), ethylene glycol dinitrate (EGDN), glycerine trinitrate (NG, nitroglycerine), triacetone triperoxide (TATP), and pentaerythritol tetranitrate (PETN) were successfully recorded. The most interesting aspect of the current application is that it enabled simultaneous detection of both the target analyte and its decomposition products...
January 10, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28069837/high-sensitive-cardiac-troponin-t-as-a-novel-predictor-for-recurrence-of-atrial-fibrillation-after-radiofrequency-catheter-ablation
#4
Koki Nakanishi, Shota Fukuda, Hajime Yamashita, Toshifumi Hasegawa, Michihiko Kosaka, Naoya Shirai, Kenei Shimada, Junichi Yoshikawa, Atsushi Tanaka
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28059482/aquatic-toxicity-of-photo-degraded-insensitive-munition-101-imx-101-constituents
#5
Alan J Kennedy, Aimee R Poda, Nicolas L Melby, Lee C Moores, Shinita M Jordan, Kurt A Gust, Anthony J Bednar
Insensitive munitions (IMs) are desirable alternatives to historically used formulations, such as 2,4,6-trinitrotoluene (TNT), due to their "insensitivity" to unintended detonation. The insensitive munition IMX-101 is a mixture of 2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). Environmental releases of munitions may be from production wastewaters or training; these munitions may be exposed to Ultraviolet light. Therefore, it is useful to understand the relative toxicity of IMX-101 and its constituents both before and after photo-degradation...
January 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28054330/double-sided-transparent-tio2-nanotube-ito-electrodes-for-efficient-cds-cuins2-quantum-dot-sensitized-solar-cells
#6
Chong Chen, Lanyu Ling, Fumin Li
In this paper, to improve the power conversion efficiencies (PCEs) of quantum dot-sensitized solar cells (QDSSCs) based on CdS-sensitized TiO2 nanotube (TNT) electrodes, two methods are employed on the basis of our previous work. First, by replacing the traditional single-sided working electrodes, double-sided transparent TNT/ITO (DTTO) electrodes are prepared to increase the loading amount of quantum dots (QDs) on the working electrodes. Second, to increase the light absorption of the CdS-sensitized DTTO electrodes and improve the efficiency of charge separation in CdS-sensitized QDSSCs, copper indium disulfide (CuInS2) is selected to cosensitize the DTTO electrodes with CdS, which has a complementary property of light absorption with CdS...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28040285/diagnostic-performance-of-a-high-sensitive-troponin-t-assay-and-a-troponin-t-point-of-care-assay-in-the-clinical-routine-of-an-emergency-department-a-clinical-cohort-study
#7
Anna Slagman, Johannes von Recum, Martin Möckel, Fabian Holert, Dirk Meyer Zum Büschenfelde, Christian Müller, Julia Searle
BACKGROUND: A point of care test (POCT) for troponin T (TnT) in the Emergency Department (ED) was compared to a high-sensitivity TnT (hsTnT) central laboratory test (CLT) to determine the influence of test system and different cut-off values on the diagnostic performance in patients with suspected acute coronary syndrome (ACS) under routine conditions. METHODS: All patients with routine TnT testing in the ED were enrolled. Only internal medicine patients without STEMI and with both troponin values were analyzed...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28032325/tio2-nanotube-carbon-tnt-c-as-support-for-pt-based-catalyst-for-high-methanol-oxidation-reaction-in-direct-methanol-fuel-cell
#8
M Abdullah, S K Kamarudin, L K Shyuan
In this study, TiO2 nanotubes (TNTs) were synthesized via a hydrothermal method using highly concentrated NaOH solutions varying from 6 to 12 M at 180 °C for 48 h. The effects of the NaOH concentration and the TNT crystal structure on the performance for methanol oxidation were investigated to determine the best catalyst support for Pt-based catalysts. The results showed that TNTs produced with 10 M NaOH exhibited a length and a diameter of 550 and 70 nm, respectively; these TNTs showed the best nanotube structure and were further used as catalyst supports for a Pt-based catalyst in a direct methanol fuel cell...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28027919/physicochemical-characterisation-and-investigation-of-the-bonding-mechanisms-of-api-titanate-nanotube-composites-as-new-drug-carrier-systems
#9
Barbara Sipos, Klára Pintye-Hódi, Zoltán Kónya, András Kelemen, Géza Regdon, Tamás Sovány
Titanate nanotube (TNT) has recently been explored as a new carrier material for active pharmaceutical ingredients (API). The aim of the present work was to reveal the physicochemical properties of API-TNT composites, focusing on the interactions between the TNTs and the incorporated APIs. Drugs belonging to different Biopharmaceutical Classification System (BCS) classes were loaded into TNTs: diltiazem hydrochloride (BCS I.), diclofenac sodium (BCS II.), atenolol (BCS III.) and hydrochlorothiazide (BCS IV...
December 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28017545/high-sensitivity-troponin-t-assay-in-asymptomatic-high-cardiovascular-risk-patients-the-tusarc-registry
#10
Isabel Álvarez, Luis Hernández, Héctor García, Vicente Villamandos, María Gracia López, Jorge Palazuelos Molinero, Diego Martín Raymondi
INTRODUCTION AND OBJECTIVES: High-sensitivity troponin T assays (Hs-TnT) have been carried out in selected populations in clinical trials and in registries of the general population with low cardiovascular risk (CVR). The aim of this study was to determine the proportion of individuals with detectable Hs-TnT and the proportion of individuals with elevated Hs-TnT in a Spanish population of asymptomatic individuals with very high CVR, as well as the parameters associated with Hs-TnT elevation...
December 22, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28013156/colorimetric-sensor-arrays-based-on-pattern-recognition-for-the-detection-of-nitroaromatic-molecules
#11
Wei Lu, Xiao Dong, Lili Qiu, Zequn Yan, Zihui Meng, Min Xue, Xuan He, Xueyong Liu
This research demonstrated that, in a colorimetric sensor array, 2,4,6-trinitrotoluene (TNT), 2,6-dinitrotoluene (2,6-DNT), 2,4-dinitrotoluene (2,4-DNT) and 4-nitrotoluene (4-MNT) were identifiable through a unique pattern in a qualitative and semi-quantitative manner. The adsorption capacity of the molecularly imprinted colloidal particles (MICs) for their corresponding templates was 0.27mmol TNT/g, 0.22mmol 2,6-DNT/g, 0.31mmol 2,4-DNT/g and 0.16mmol 4-MNT/g, respectively. Every optical sensor utilized in the arrays contained three-dimensional molecularly imprinted photonic crystal (MIPC) sensor with different imprinted templates...
December 14, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28008977/differential-identity-of-filopodia-and-tunneling-nanotubes-revealed-by-the-opposite-functions-of-actin-regulatory-complexes
#12
Elise Delage, Diégo Cordero Cervantes, Esthel Pénard, Christine Schmitt, Sylvie Syan, Andrea Disanza, Giorgio Scita, Chiara Zurzolo
Tunneling Nanotubes (TNTs) are actin enriched filopodia-like protrusions that play a pivotal role in long-range intercellular communication. Different pathogens use TNT-like structures as "freeways" to propagate across cells. TNTs are also implicated in cancer and neurodegenerative diseases, making them promising therapeutic targets. Understanding the mechanism of their formation, and their relation with filopodia is of fundamental importance to uncover their physiological function, particularly since filopodia, differently from TNTs, are not able to mediate transfer of cargo between distant cells...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28008709/will-you-still-need-me-ca-2-tnt-and-dhpr-will-you-still-cleave-me-calpain-when-i-m-64
#13
José Renato Pinto, Judy Muller-Delp, P Bryant Chase
No abstract text is available yet for this article.
December 23, 2016: Aging Cell
https://www.readbyqxmd.com/read/28006730/enhancement-of-microbial-2-4-6-trinitrotoluene-transformation-with-increased-toxicity-by-exogenous-nutrient-amendment
#14
Shih-Hsiung Liang, Duen-Wei Hsu, Chia-Ying Lin, Chih-Ming Kao, Da-Ji Huang, Chih-Ching Chien, Ssu-Ching Chen, Isheng Jason Tsai, Chien-Cheng Chen
In this study, the bacterial strain Citrobacter youngae strain E4 was isolated from 2,4,6-trinitrotoluene (TNT)-contaminated soil and used to assess the capacity of TNT transformation with/without exogenous nutrient amendments. C. youngae E4 poorly degraded TNT without an exogenous amino nitrogen source, whereas the addition of an amino nitrogen source considerably increased the efficacy of TNT transformation in a dose-dependent manner. The enhanced TNT transformation of C. youngae E4 was mediated by increased cell growth and up-regulation of TNT nitroreductases, including NemA, NfsA and NfsB...
December 19, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28005071/rab8a-rab11a-regulate-intercellular-communications-between-neural-cells-via-tunneling-nanotubes
#15
Hui Zhu, Chengbin Xue, Xi Xu, Yibing Guo, Xiaohong Li, Jingjing Lu, Shaoqing Ju, Yongjun Wang, Zheng Cao, Xiaosong Gu
Tunneling nanotubes (TNTs) are F-actin-based membrane tubes, and can form between cultured cells and within vital tissues. TNTs mediate intercellular communications that range from electrical signaling to the transfer of organelles. Following peripheral nerve injury, the orchestrated intercellular communications among neural and non-neural cells are required for effective nerve regeneration. It remains unknown whether TNTs exist between neural cells in the peripheral nerve system and how TNTs affect neural regeneration...
December 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28004139/genome-shuffling-of-stenotrophomonas-maltophilia-ok-5-for-improving-the-degradation-of-explosive-rdx-hexahydro-1-3-5-trinitro-1-3-5-triazine
#16
Bheong-Uk Lee, Moon-Seop Choi, Dong-Min Kim, Kye-Heon Oh
A genome-shuffled Stenotrophomonas maltophilia strain showing the enhanced ability of RDX degradation was constructed, and its characteristics were compared with those of the wild-type one. The shuffled strain was able to completely degrade 25, 50, and 75 µM RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) within 10, 30, and 50 days, respectively. However, it took 30 and 70 days for the wild-type strain to degrade 25 and 50 µM RDX, respectively, and at day 70, the strain degraded only 67% of 75 µM RDX...
February 2017: Current Microbiology
https://www.readbyqxmd.com/read/27975185/l71f-mutation-in-rat-cardiac-troponin-t-augments-crossbridge-recruitment-and-detachment-dynamics-against-%C3%AE-myosin-heavy-chain-but-not-against-%C3%AE-myosin-heavy-chain
#17
Sherif M Reda, Sampath K Gollapudi, Murali Chandra
The N-terminal extension of human cardiac troponin T (TnT), which modulates myofilament Ca(2+) sensitivity, contains several hypertrophic cardiomyopathy (HCM)-causing mutations including S69F. However, the functional consequence of S69F mutation is unknown. The human analog of S69F in rat TnT is L71F (TnTL71F). Because the functional consequences due to structural changes in the N-terminal extension are influenced by the type of myosin heavy chain (MHC) isoform, we hypothesized that the TnTL71F-mediated effect would be differently modulated by α- and β-MHC isoforms...
December 14, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27974700/tunneling-nanotube-tnt-formation-is-downregulated-by-cytarabine-and-nf-%C3%AE%C2%BAb-inhibition-in-acute-myeloid-leukemia-aml
#18
Maria Omsland, Øystein Bruserud, Bjørn T Gjertsen, Vibeke Andresen
Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular communication in the leukemic bone marrow participates in disease development, progression and chemoresistance. Tunneling nanotubes (TNTs) are intercellular communication structures involved in transport of cellular contents and pathogens, also demonstrated to play a role in both cell death modulation and chemoresistance. Here we investigated the presence of TNTs by live fluorescent microscopy and identified TNT formation between primary AML cells and in AML cell lines...
December 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27932879/study-of-a-new-bone-targeting-titanium-implant-bone-interface
#19
Xiangning Liu, Ye Zhang, Shaobing Li, Yayu Wang, Ting Sun, Zejian Li, Lizhao Cai, Xiaogang Wang, Lei Zhou, Renfa Lai
New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant-bone interface was also successfully constructed by implanting the delivery system in vivo...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932136/prognostic-value-of-high-sensitivity-troponin-t-to-identify-patients-at-risk-of-left-ventricular-graft-dysfunction-after-heart-transplantation
#20
A B Méndez, J Ordonez-Llanos, S Mirabet, J Galan, M L Maestre, V Brossa, M T Rivilla, L López, T Koller, A Sionis, E Roig
Primary graft dysfunction after heart transplantation (HTx) has a very high mortality rate, especially if the left ventricle (PGD-LV) is involved. Early diagnosis is important to select the appropriate therapy to improve prognosis. The value of high-sensitivity troponin T (HS-TNT) measurement obtained at patient arrival at the intensive care unit was analyzed in 71 HTx patients. Mild or moderate PGD-LV was defined by hemodynamic compromise with one of the following criteria: left ventricular ejection fraction <40%, hemodynamic compromise with right atrial pressure >15 mm Hg, pulmonary capillary wedge pressure >20 mm Hg, cardiac index <2...
November 2016: Transplantation Proceedings
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