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https://www.readbyqxmd.com/read/29786423/electrochemical-determination-of-tnt-dnt-rdx-and-hmx-with-gold-nanoparticles-poly-carbazole-aniline-film-modified-glassy-carbon-sensor-electrodes-imprinted-for-molecular-recognition-of-nitroaromatics-and-nitramines
#1
Şener Sağlam, Ayşem Üzer, Erol Erçağ, Reşat Apak
Since nitroaromatic and nitramine type energetic materials, mostly arising from military activities, are persistent pollutants in soil and groundwater, on-site sensing of these hazardous chemicals has gained importance. A novel electrochemical sensor was designed for detecting nitroaromatic and nitramine type energetic materials, relying on gold nanoparticles (Aunano ) -modified glassy carbon (GC) electrode coated with nitro-energetic memory poly(carbazole-aniline) copolymer (Cz- co-ANI) film (e.g., TNT memory-GC/P(Cz- co-ANI)-Aunano modified electrode)...
May 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29785212/reduction-of-vascular-inflammation-ldl-c-or-both-for-the-protection-from-cardiovascular-events
#2
REVIEW
Andromachi Reklou, Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos, Dimitris Patoulias, Vasilios G Athyros
Background: Low density lipoprotein cholesterol (LDL-C) and low grade arterial inflammation are key pathogenic factors for atherosclerosis and its manifestation, cardiovascular disease (CVD). Objective: In this narrative review we assessed if decreasing LDL-C levels or inflammation or both is more effective in reducing CVD events. Results: In the Scandinavian Simvastatin Survival Study (4S), all statin trials of the 90s' and the Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) the benefit came from the LDL-C reduction...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29776992/cardiomyopathy-mutation-f88l-in-troponin-t-abolishes-length-dependency-of-myofilament-ca-2-sensitivity
#3
Sherif M Reda, Murali Chandra
Recent clinical studies have revealed a new hypertrophic cardiomyopathy-associated mutation (F87L) in the central region of human cardiac troponin T (TnT). However, despite its implication in several incidences of sudden cardiac death in young and old adults, whether F87L is associated with cardiac contractile dysfunction is unknown. Because the central region of TnT is important for modulating the muscle length-mediated recruitment of new force-bearing cross-bridges (XBs), we hypothesize that the F87L mutation causes molecular changes that are linked to the length-dependent activation of cardiac myofilaments...
May 18, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29765077/homotypic-endothelial-nanotubes-induced-by-wheat-germ-agglutinin-and-thrombin
#4
Lucia Pedicini, Katarina T Miteva, Verity Hawley, Hannah J Gaunt, Hollie L Appleby, Richard M Cubbon, Katarzyna Marszalek, Mark T Kearney, David J Beech, Lynn McKeown
Endothelial barrier formation is maintained by intercellular communication through junctional proteins. The mechanisms involved in maintaining endothelial communication subsequent to barrier disruption remain unclear. It is known that low numbers of endothelial cells can be interconnected by homotypic actin-driven tunneling nanotubes (TNTs) which could be important for intercellular transfer of information in vascular physiology. Here we sought insight into the triggers for TNT formation. Wheat germ agglutinin, a C-type lectin and known label for TNTs, unexpectedly caused striking induction of TNTs...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762499/a-high-aspect-ratio-bifurcated-128-microchannel-microfluidic-device-for-environmental-monitoring-of-explosives
#5
Paul T Charles, Varun Wadhwa, Amara Kouyate, Kelly J Mesa-Donado, Andre A Adams, Jeffrey R Deschamps, Anne W Kusterbeck
Design and evolution of explosives monitoring and detection platforms to address the challenges of trace level chemical identification have led investigations into the use of intricately designed microfluidic devices. Microfluidic devices are unique tools that possess distinct characteristics that, when designed properly and configured with optical and fluidic components, can produce detection platforms with unmatched performance levels. Herein, we report the design, fabrication and integration of a bifurcated high aspect ratio microfluidic device containing 128 microchannels (40 mm × 40 μm × 250 μm; L × W × H) for explosives detection at trace levels...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29760549/nanostructured-ag-substituted-fluorhydroxyapatite-tio-2-coatings-for-enhanced-bactericidal-effects-and-osteoinductivity-of-ti-for-biomedical-applications
#6
Yong Huang, Guiqin Song, Xiaotong Chang, Zhenhui Wang, Xuejiao Zhang, Shuguang Han, Zhuobin Su, Hejie Yang, Dongdong Yang, Xiaojun Zhang
Background: Poor mechanical properties, undesirable fast dissolution rate, and lack of antibacterial activity limit the application of hydroxyapatite (HA) as an implant coating material. To overcome these limitations, a hybrid coating of Ag+ -substituted fluorhydroxyapatite and titania nanotube (TNT) was prepared. Methods: The incorporation of silver into the HA-TiO2 hybrid coating improves its antimicrobial properties. The addition of F as a second binary element increases the structural stability of the coating...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29756512/profile-of-roche-s-elecsys-troponin-t-gen-5-stat-blood-test-a-high-sensitivity-cardiac-troponin-assay-for-diagnosing-myocardial-infarction-in-the-emergency-department
#7
Peter A Kavsak, James E Andruchow, Andrew D McRae, Andrew Worster
The Elecsys Troponin T Gen 5 STAT test (distributed in the United States (US) by Roche Diagnostics, Indianapolis, IN) is the first high-sensitivity cardiac troponin test approved for use by the FDA in the US (2017). Areas covered: The test offers clinicians the opportunity for more rapid decision-making for diagnosing myocardial infarction (MI) in the emergency department (ED). The Troponin T Gen 5 STAT test (labeled as TNT-G5ST on the reagent pack) is similar to the Troponin T hs STAT (TNT-HSST) and Troponin T hs (TNT-HS) tests that have been available outside the US since 2009...
May 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29752124/fabrication-of-hyaluronidase-responsive-biocompatible-multilayers-on-bmp2-loaded-titanium-nanotube-for-the-bacterial-infection-prevention
#8
Linawati Sutrisno, Yan Hu, Xinkun Shen, Menghuan Li, Zhong Luo, Liangliang Dai, Sixiang Wang, Julia Li Zhong, Kaiyong Cai
Infection associated with orthopedic implants is the chief cause of implant failure. An important consideration to prevent the infection at implants is to inhibit the biofilm formation for the initial 6 h. Therefore, we fabricated hyaluronidase-sensitive multilayers of chitosan (Chi)/sodium hyaluronate-lauric acid (SL) onto the surface of bone morphogenetic protein 2 (BMP2) loaded titanium nanotube (TNT) via spin-assisted layer-by-layer technique. The results of both Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1 H NMR) confirmed the successful synthesis of SL...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29749315/irisin-in-coronary-bypass-surgery
#9
Suna Aydin, Zekiye Catak, Mehmet Nesimi Eren, Suleyman Aydin, Askin Ender Topal
INTRODUCTION: In coronary bypass surgery, after cardiopulmonary bypass is initiated by arterial cannulation in the ascending aorta and venous cannulation through a single vein generally in the right atrium, the process of cooling the patient is started. There is a relation between cooling the patient and irisin, which is responsible for releasing heat. OBJECTIVE: Therefore, the main objective of the present study is to explore how irisin concentrations and some other panel of myocardium injury in patients undergoing coronary artery bypass surgery changes...
May 11, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29748349/independent-prognostic-value-of-serum-soluble-st2-measurements-in-patients-with-heart-failure-and-a-reduced-ejection-fraction-in-the-paradigm-hf-trial-prospective-comparison-of-arni-with-acei-to-determine-impact-on-global-mortality-and-morbidity-in-heart-failure
#10
Eileen O'Meara, Margaret F Prescott, Brian Claggett, Jean L Rouleau, Lu-May Chiang, Scott D Solomon, Milton Packer, John J V McMurray, Michael R Zile
BACKGROUND: Soluble ST2 (sST2) is associated with cardiac remodeling and fibrosis. In chronic heart failure, the predictive value of sST2 has not been evaluated in a model that includes both NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity cardiac troponin T), in a trial in which treatment had a major impact. Therefore, the effects of treatment on sST2 levels in PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the relationships between sST2 and outcomes, and the prognostic utility of various sST2 partition values were examined...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29748323/the-rise-collapse-and-compaction-of-mt-mantap-from-the-3-september-2017-north-korean-nuclear-test
#11
Teng Wang, Qibin Shi, Mehdi Nikkhoo, Shengji Wei, Sylvain Barbot, Douglas Dreger, Roland Bürgmann, Mahdi Motagh, Qi-Fu Chen
Surveillance of clandestine nuclear tests relies on a global seismic network, but the potential of spaceborne monitoring has been underexploited. Here, we determined the complete surface displacement field of up to 3.5 m of divergent horizontal motion with 0.5 m of subsidence associated with North Korea's largest underground nuclear test using satellite radar imagery. Combining insight from geodetic and seismological remote sensing, we found that the aftermath of the initial explosive deformation involved subsidence associated with sub-surface collapse and aseismic compaction of the damaged rocks of the test site...
May 10, 2018: Science
https://www.readbyqxmd.com/read/29713086/carboplatin-in-brca1-2-mutated-and-triple-negative-breast-cancer-brcaness-subgroups-the-tnt-trial
#12
Andrew Tutt, Holly Tovey, Maggie Chon U Cheang, Sarah Kernaghan, Lucy Kilburn, Patrycja Gazinska, Julie Owen, Jacinta Abraham, Sophie Barrett, Peter Barrett-Lee, Robert Brown, Stephen Chan, Mitchell Dowsett, James M Flanagan, Lisa Fox, Anita Grigoriadis, Alexander Gutin, Catherine Harper-Wynne, Matthew Q Hatton, Katherine A Hoadley, Jyoti Parikh, Peter Parker, Charles M Perou, Rebecca Roylance, Vandna Shah, Adam Shaw, Ian E Smith, Kirsten M Timms, Andrew M Wardley, Gregory Wilson, Cheryl Gillett, Jerry S Lanchbury, Alan Ashworth, Nazneen Rahman, Mark Harries, Paul Ellis, Sarah E Pinder, Judith M Bliss
Germline mutations in BRCA1/2 predispose individuals to breast cancer (termed germline-mutated BRCA1/2 breast cancer, gBRCA-BC) by impairing homologous recombination (HR) and causing genomic instability. HR also repairs DNA lesions caused by platinum agents and PARP inhibitors. Triple-negative breast cancers (TNBCs) harbor subpopulations with BRCA1/2 mutations, hypothesized to be especially platinum-sensitive. Cancers in putative 'BRCAness' subgroups-tumors with BRCA1 methylation; low levels of BRCA1 mRNA (BRCA1 mRNA-low); or mutational signatures for HR deficiency and those with basal phenotypes-may also be sensitive to platinum...
April 30, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29707318/the-comparison-of-predictive-factors-regarding-prognoses-and-invasion-of-thymic-neuroendocrine-tumors-preoperatively-and-postoperatively
#13
Dongliang Bian, Mengfan Qi, Junjie Hu, Ye Ning, Feng Zhou, Ke Fei, Peng Zhang
Background: Thymic neuroendocrine tumors (TNT), in the anterior mediastinum, are extremely rare diseases which have significantly poor prognoses. Studies have rarely provided conclusive evidence of the prognostic factors of TNT. Standard therapies have been controversial. Methods: TNT patients (n=173) were enrolled from Surveillance, Epidemiology and End Results database (SEER). Univariate and multivariate analyses were utilized to evaluate predictive factors of prognoses...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29696937/the-effects-of-atorvastatin-on-il-6-crp-blood-lipid-and-myocardial-protection-of-interventional-therapy-in-patients-with-acute-myocardial-infarction
#14
Kai Wang, Lili Chen, Li Liu, Yikai Cui, Xiaohu Zhang, Jun Jiang
BACKGROUND: To analyze the changes of interleukin-6 (IL-6), C-reactive protein (CRP), blood lipids and myocardial indexes after treatment of patients with acute myocardial infarction (AMI) with intensive atorvastatin and interventional therapy, and its clinical significance. METHODS: A total of 78 patients diagnosed with AMI in our hospital from March 2016 to February 2017 were selected, and divided into treatment group (n=39) and control group (n=39). Patients in treatment group were treated with intensive atorvastatin based on conventional therapy before and after percutaneous coronary intervention (PCI), while those in control group were treated with conventional therapy before and after PCI...
April 24, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29694027/an-ims-fragmenter-ims-analog-of-a-triple-quadrupole-for-high-resolution-ion-analysis-at-atmospheric-pressure
#15
Mario Amo-Gonzalez, Irene Carnicero, Sergio Pérez, Rafael Delgado, Gary A Eiceman, Gonzalo Fernandez De La Mora, Juan Fernandez de la Mora
Two differential mobility analyzers (DMAs) acting as narrow band mobility filters are coupled in series, with a thermal fragmentation cell placed in between, such that parent ions selected in DMA1 are fragmented in the cell at atmospheric pressure, and their product ions are analyzed on DMA2. Additional mass spectrometer analysis is performed for ion identification purposes. A key feature of the tandem DMA is the short residence time (~0.2 ms) of ions in the analyzer, compared to tens of ms in drift tube IMS...
April 25, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29687474/field-validation-of-pocis-for-monitoring-at-underwater-munitions-sites
#16
Gunther Rosen, Guilherme R Lotufo, Robert D George, Bill Wild, Lauren K Rabalais, Shane Morrison, Jason B Belden
The present study evaluated Polar Organic Chemical Integrative Samplers (POCIS) for quantification of conventional munitions constituents (MC), including trinitrotoluene (TNT), aminodinitrotoluenes, diaminonitrotoluenes, dinitrotoluene, and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in a field setting. POCIS were deployed at varying distances from the commonly used explosive formulation Composition B (39.5% TNT, 59.5% RDX, 1% wax) in an embayment of Santa Rosa Sound (Florida, USA). Time-weighted averaged (TWA) water concentrations from a 13-day deployment ranged from 9-103 ng/L for TNT and RDX approximately 0...
April 24, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29683158/understanding-the-hydrogen-transfer-mechanism-for-the-biodegradation-of-2-4-6-trinitrotoluene-catalyzed-by-pentaerythritol-tetranitrate-reductase-molecular-dynamics-simulations
#17
Zhilin Yang, Junxian Chen, Yang Zhou, Hui Huang, Dingguo Xu, Chaoyang Zhang
The explosive 2,4,6-trinitrotoluene (TNT) is a highly toxic pollutant. Biodegradation is inevitably one of the most cost-effective and enviromentally friendly means of removing TNT pollution. However, the aromatic derivatives from the reduction of nitro groups by several classic enzymes are still toxic. Besides the reduction of nitro groups, pentaerythritol tetranitrate reductase (PETNR) offers a potential route to ring fission and complete degradation of TNT through the pathway of the Meisenheimer complex...
April 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29674801/immunomodulatory-properties-of-titanium-dioxide-nanostructural-materials
#18
T Sree Latha, Madhava C Reddy, Prasad V R Durbaka, Shankar V Muthukonda, Dakshayani Lomada
OBJECTIVES: Although titanium dioxide (TiO2 ) nanostructural materials have been widely used in Biology and Medicine, very little is known about immunomodulation mechanism of these materials. Objectives of this study are to investigate in vitro immunomodulatory effects of TiO2 . Immunosuppressant may lower immune responses and are helpful for the treatment of graft versus host diseases and autoimmune disorders. MATERIALS AND METHODS: In this study, we used H2 Ti3 O7 titanium dioxide nanotubes (TNT) nanotubes along with commercial TiO2 nanoparticles (TNP) and TiO2 fine particles (TFP)...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674066/simple-multispectral-imaging-approach-for-determining-the-transfer-of-explosive-residues-in-consecutive-fingerprints
#19
Heidi Lees, Félix Zapata, Merike Vaher, Carmen García-Ruiz
This novel investigation focused on studying the transfer of explosive residues (TNT, HMTD, PETN, ANFO, dynamite, black powder, NH4 NO3 , KNO3 , NaClO3 ) in ten consecutive fingerprints to two different surfaces - cotton fabric and polycarbonate plastic - by using multispectral imaging (MSI). Imaging was performed employing a reflex camera in a purpose-built photo studio. Images were processed in MATLAB to select the most discriminating frame - the one that provided the sharpest contrast between the explosive and the material in the red-green-blue (RGB) visible region...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29670348/effects-of-hydrogenated-tio-2-nanotube-arrays-on-protein-adsorption-and-compatibility-with-osteoblast-like-cells
#20
Ran Lu, Caiyun Wang, Xin Wang, Yuji Wang, Na Wang, Joshua Chou, Tao Li, Zhenting Zhang, Yunhan Ling, Su Chen
Background: Modified titanium (Ti) substrates with titanium dioxide (TiO2 ) nanotubes have broad usage as implant surface treatments and as drug delivery systems. Methods: To improve drug-loading capacity and accelerate bone integration with titanium, in this study, we hydrogenated anodized titanium dioxide nanotubes (TNTs) by a thermal treatment. Three groups were examined, namely: hydrogenated TNTs (H2 -TNTs, test), unmodified TNTs (air-TNTs, control), and Ti substrates (Ti, control)...
2018: International Journal of Nanomedicine
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