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https://www.readbyqxmd.com/read/28521129/integrating-results-across-methodologies-is-essential-for-producing-robust-neuronal-taxonomies
#1
Mark S Cembrowski, Nelson Spruston
Elucidating the diversity and spatial organization of cell types in the brain is an essential goal of neuroscience, with many emerging technologies helping to advance this endeavor. Using a new in situ hybridization method that can measure the expression of hundreds of genes in a given mouse brain section (amplified seqFISH), Shah et al. (2016) describe a spatial organization of hippocampal cell types that differs from previous reports. In seeking to understand this discrepancy, we find that many of the barcoded genes used by seqFISH to characterize this spatial organization, when cross-validated by other sensitive methodologies, exhibit negligible expression in the hippocampus...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28504326/preoperative-colonization-in-pediatric-cardiac-surgery-and-its-impact-on-postoperative-infections
#2
Simona Silvetti, Marco Ranucci, Giuseppe Isgrò, Valentina Villa, Elena Costa
BACKGROUND: Patients with congenital heart defects are frequently hospitalized before surgery. This exposes them to a high risk for pathogen colonization. There are limited data on colonization prevalence in the pediatric cardiac population, and limited data concerning its potential role in the risk of developing infections after cardiac surgery. AIM: This study aimed to verify the impact of preoperative colonization on postoperative infections in a population of pediatric cardiac surgery patients coming from Italy and developing countries...
May 15, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28503788/indicators-of-inappropriate-tumour-marker-use-through-the-mining-of-electronic-health-records
#3
Massimo Gion, Giulia Cardinali, Chiara Trevisiol, Marco Zappa, Giulia Rainato, Aline S C Fabricio
RATIONALE, AIMS, AND OBJECTIVES: Although the issue of monitoring appropriateness of tumour markers (TMs) request in outpatients remains crucial, proper indicators are still demanding. The present study developed and explored indicators of inappropriate TM ordering in outpatients through the data mining of electronic health records (EHRs). METHODS: Carcinoembryonic antigen (CEA), alfa-fetoprotein (AFP), carbohydrate antigen (CA)125, CA15.3, CA19.9, and prostate-specific antigen (PSA) ordered in outpatients during a year were examined by mining EHRs of a Local Health Authority in Italy...
May 15, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28496125/enhancing-specific-disruption-of-intracellular-protein-complexes-by-hydrocarbon-stapled-peptides-using-lipid-based-delivery
#4
D Thean, J S Ebo, T Luxton, Xue'Er Cheryl Lee, T Y Yuen, F J Ferrer, C W Johannes, D P Lane, C J Brown
Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability. Peptide stapling has been proposed to circumvent these limitations but recent data has suggested that this method does not universally solve the problem of cell entry and can lead to molecules with off target cell lytic properties. To address these issues a library of stapled peptides was synthesized and screened to identify compounds that bound Mdm2 and activated cellular p53...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28480018/elements-of-metacommunity-structure-in-amazonian-zygoptera-among-streams-under-different-spatial-scales-and-environmental-conditions
#5
Leandro Schlemmer Brasil, Thiago Bernardi Vieira, José Max Barbosa de Oliveira-Junior, Karina Dias-Silva, Leandro Juen
An important aspect of conservation is to understand the founding elements and characteristics of metacommunities in natural environments, and the consequences of anthropogenic disturbance on these patterns. In natural Amazonian environments, the interfluves of the major rivers play an important role in the formation of areas of endemism through the historical isolation of species and the speciation process. We evaluated elements of metacommunity structure for Zygoptera (Insecta: Odonata) sampled in 93 Amazonian streams distributed in two distinct biogeographic regions (areas of endemism)...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28472580/gps-perspectives-on-prescribing-intrauterine-contraceptive-devices
#6
Gabrielle Lodge, Lena Sanci, Meredith J Temple-Smith
BACKGROUND: Globally, 14% of women use intrauterine contraceptive devices (IUCDs) for prevention of unplanned pregnancy. In Australia, the use of IUCDs is negligible at METHODS: GPs participated in qualitative interviews in February-May 2016, exploring their knowledge, attitudes and practice around IUCDs. Data were thematically analysed. RESULTS: Overall, 17 GPs were interviewed. They identified key barriers to prescription of IUCDs as misconceptions brought to the consultation, lack of current GP inserters, and issues in referral of patients for insertion...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28463041/effect-of-pressurized-metered-dose-inhaler-spray-characteristics-and-particle-size-distribution-on-drug-delivery-efficiency
#7
Morteza Yousefi, Kiao Inthavong, Jiyuan Tu
BACKGROUND: A key issue in pulmonary drug delivery is improvement of the delivery device for effective and targeted treatment. Pressurized metered dose inhalers (pMDIs) are the most popular aerosol therapy device for treating lung diseases. This article studies the effect of spray characteristics: injection velocity, spray cone angle, particle size distribution (PSD), and its mass median aerodynamic diameter (MMAD) on drug delivery. METHODS: An idealized oral airway geometry, extending from mouth to the main bronchus, was connected to a pMDI device...
May 2, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28460757/our-intellectuals-have-failed-us-system-of-a-down
#8
EDITORIAL
Sundeep Mishra
Medical profession is at cross-roads. On one hand are issues like medical mal-practice and negligence but on the other are loss of respect, low re-imbursement, lawsuits against medical professionals, violence against physicians all contributing to a lot of stress as also a high suicide rate among medical practitioners. While some of the problems seem related to changing societal norms, most of them seem to stem from a failure, active or passive on the part of medical intellectual, moving away from altruism, justice and self regulation to pursuance of self interest with a consequent loss of trust in doctor-patient relationship...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28453254/gene-transfection-mediated-by-catiomers-requires-free-highly-charged-polymer-chains-to-overcome-intracellular-barriers
#9
Lindomar J C Albuquerque, Carlos E de Castro, Karin A Riske, Maria C Carlan da Silva, Paulo I R Muraro, Vanessa Schmidt, Cristiano Giacomelli, Fernando C Giacomelli
The prospective use of the block copolymers poly(ethylene oxide)113-b-poly[2-(diethylamino)ethyl methacrylate]50 (PEO113-b-PDEA50) and poly[oligo(ethylene glycol)methyl ether methacrylate]70-b-poly[oligo(ethylene glycol)methyl ether methacrylate10-co-2-(diethylamino)ethyl methacrylate47-co-2-(diisopropylamino)ethyl methacrylate47] (POEGMA70-b-P(OEGMA10-co-DEA47-co-DPA47)) as nonviral gene vectors was evaluated. The polymers are able to properly condense DNA into nanosized particles (RH ≈ 75 nm), which are marginally cytotoxic and can be uptaken by cells...
May 5, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28449388/unobserved-health-care-expenditures-how-important-is-censoring-in-register-data
#10
Christian Philipp Rudolf Schmid
Accurate information on individuals' health service use is important for evaluating health policies and analyzing health care demand. Although register data are considered to be more reliable than survey data, little is known about the extent and effect of censoring of the expenditure distribution in register data. We exploit a recent change in the health provider remuneration system in several Swiss cantons to empirically investigate whether censoring occurs when individuals do not have to disclose their health service use below their deductible level...
April 27, 2017: Health Economics
https://www.readbyqxmd.com/read/28411426/thoron-mitigation-system-based-on-charcoal-bed-for-applications-in-thorium-fuel-cycle-facilities-part-2-development-characterization-and-performance-evaluation
#11
K Sudeep Kumara, B K Sahoo, J J Gaware, B K Sapra, Y S Mayya, N Karunakara
Exposure due to thoron ((220)Rn) gas and its decay products in a thorium fuel cycle facility handling thorium or (232)U/(233)U mixture compounds is an important issue of radiological concern requiring control and mitigation. Adsorption in a flow-through charcoal bed offers an excellent method of alleviating the release of (220)Rn into occupational and public domain. In this paper, we present the design, development, and characterization of a Thoron Mitigation System (TMS) for industrial application. Systematic experiments were conducted in the TMS for examining the (220)Rn mitigation characteristics with respect to a host of parameters such as flow rate, pressure drop, charcoal grain size, charcoal mass and bed depth, water content, and heat of the carrier gas...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28410567/farm-suicides-in-new-zealand-2007-2015-a-review-of-coroners-records
#12
Annette L Beautrais
OBJECTIVE: Economic recessions and severe weather events are often associated with increased suicide rates. The Global Dairy Crisis 2015/2016 led to an economic downturn in the New Zealand dairy farming industry and, coupled with droughts in some regions and floods in others, raised fears about increased suicide rates among farmers. However, little was known about suicides in the farming sector. This study reviews characteristics of recent farm-related suicides in New Zealand and assesses the extent to which financial stresses contributed to the deaths...
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28389672/contact-angle-measurement-of-small-capillary-length-liquid-in-super-repelled-state
#13
Tingyi Leo Liu, Chang-Jin Cj Kim
The difficulty of measuring very large contact angles (>150 degrees) has become more relevant with the increased popularity of super-repellent surfaces. Measurement is more difficult for dynamic contact angles, for which theoretical profiles do not fit well, and small capillary length liquids, whose sessile droplets sag by gravity. Here, we expand the issue to the limit by investigating dynamic contact angles of liquids with an extremely small capillary length (<1.0 mm), empowered by the superomniphobic surface that can super-repel even fluorinated solvents, which highly wet all materials...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381499/cytosolic-and-chloroplastic-dhars-cooperate-in-oxidative-stress-driven-activation-of-the-salicylic-acid-pathway
#14
Marie-Sylviane Rahantaniaina, Shengchun Li, Gilles Chatel-Innocenti, Andrée Tuzet, Emmanuelle Issakidis-Bourguet, Amna Mhamdi, Graham Noctor
The complexity of plant antioxidative systems gives rise to many unresolved questions. One relates to the functional importance of dehydroascorbate reductases (DHARs) in interactions between ascorbate and glutathione. To investigate this issue, we produced a complete set of loss-of-function mutants for the three annotated Arabidopsis DHARs. The combined loss of DHAR1 and DHAR3 expression decreased extractable activity to very low levels but had little effect on phenotype or ascorbate and glutathione pools in standard conditions...
April 5, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28375648/perfectionism-in-argentina-and-the-united-states-measurement-structure-invariance-and-implications-for-depression
#15
Fernán G Arana, Kenneth G Rice, Jeffrey S Ashby
The Revised Almost Perfect Scale (APS-R; Slaney, Mobley, Trippi, Ashby, & Johnson, 1996 ) was designed to measure perfectionistic strivings (standards), perfectionistic concerns (discrepancy), and preferences for neatness and organization (order). In this study, English and Spanish (Arana, Keegan, & Rutsztein, 2009 ) versions of the APS-R were compared in samples of 283 college students in Argentina and 311 U.S. students. The results offered support for cross-national scalar invariance for discrepancy and order items but standards items, with a few exceptions, raised concerns about their cross-national comparability...
April 4, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28371295/selection-of-best-conditions-of-inoculum-preparation-for-optimum-performance-of-the-pigment-production-process-by-talaromyces-spp-using-the-taguchi-method
#16
L Morales-Oyervides, J C Oliveira, M J Sousa-Gallagher, A Méndez-Zavala, J C Montañez
Process optimisation techniques increasingly need to be used early on in Research and Development of processes for new ingredients. There are different approaches and this paper illustrates the main issues at stake with a method that is an industry best practice, the Taguchi method, suggesting a procedure to assess the potential impact of its drawbacks. The Taguchi method has been widely used in various industrial sectors because it minimises the experimental requirements to define an optimum region of operation, which is particularly relevant when minimising variability is a target...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28365921/shechita-kosher-slaughtering-and-european-legislation
#17
Paolo S Pozzi, Trevor Waner
Shechita is the procedure of killing or slaughtering animals for food production, according to Jewish tradition and it is performed without prior stunning. USA and European legislations conditionally allow slaughter without prior stunning in the frame of religion freedom (USA) or religious/cultural traditions (EU); nevertheless some traditional events in Europe de nitely represent a concern for animal welfare. It is possible to identify animal welfare issues in the rules for shechita: correct restrain of the animal; adequacy of the instrument (knife); technical ability of the operator...
March 31, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28364358/a-mutual-authentication-framework-for-wireless-medical-sensor-networks
#18
Jangirala Srinivas, Dheerendra Mishra, Sourav Mukhopadhyay
Wireless medical sensor networks (WMSN) comprise of distributed sensors, which can sense human physiological signs and monitor the health condition of the patient. It is observed that providing privacy to the patient's data is an important issue and can be challenging. The information passing is done via the public channel in WMSN. Thus, the patient, sensitive information can be obtained by eavesdropping or by unauthorized use of handheld devices which the health professionals use in monitoring the patient...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28358492/%C3%AE-feooh-nanorods-carbon-foam-based-hierarchically-porous-monolith-for-highly-effective-arsenic-removal
#19
Xiao Ge, Yue Ma, Xiangyang Song, Guozhong Wang, Haimin Zhang, Yunxia Zhang, Huijun Zhao
Arsenic pollution in waters has become a worldwide issue, constituting a severe hazard to whole ecosystems and public health worldwide. Accordingly, it is highly desirable to design high-performance adsorbents for arsenic decontamination. Herein, a feasible strategy is developed for in situ growth of β-FeOOH nanorods (NRs) on a three-dimensional (3D) carbon foam (CF) skeleton via a simple calcination process and subsequent hydrothermal treatment. The as-fabricated 3D β-FeOOH NRs/CF monolith can be innovatively utilized for arsenic remediation from contaminated aqueous systems, accompanied by remarkably high uptake capacity of 103...
April 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28336382/migration-and-infectious-diseases
#20
REVIEW
F Castelli, G Sulis
BACKGROUND: Infectious diseases still represent an important cause of morbidity and mortality among foreign-born individuals. The rising migration flows towards Europe throughout the last few years are raising renewed concerns about management issues and the potential associated risk for the native population. AIMS: To discuss the health implications and challenges related to the four phases of migration, from first arrival to stable resettlement. SOURCES: Scientific literature and relevant statistical reports...
March 20, 2017: Clinical Microbiology and Infection
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