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Marco Baratella, Greta Forlani, Goutham U Raval, Alessandra Tedeschi, Olivier Gout, Antoine Gessain, Giovanna Tosi, Roberto S Accolla
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins, Tax-1 and HBZ, play crucial roles in the generation and maintenance of the oncogenic process. Less information is instead available on the molecular and cellular mechanisms leading to HAM/TSP. More importantly, no single specific biomarker has been described that unambiguously define the status of HAM/TSP...
January 2017: PLoS Neglected Tropical Diseases
Florent Percher, Patricia Jeannin, Sandra Martin-Latil, Antoine Gessain, Philippe V Afonso, Aurore Vidy-Roche, Pierre-Emmanuel Ceccaldi
Human T-cell Lymphotropic Virus type 1 (HTLV-1) is a human retrovirus that infects at least 5-10 million people worldwide, and is the etiological agent of a lymphoproliferative malignancy; Adult T-cell Leukemia/Lymphoma (ATLL); and a chronic neuromyelopathy, HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), as well as other inflammatory diseases such as infective dermatitis and uveitis. Besides sexual intercourse and intravenous transmission, HTLV-1 can also be transmitted from infected mother to child during prolonged breastfeeding...
February 3, 2016: Viruses
Gustavo C Román
About three-fourths of the total world population live in the tropics but consume only 6% of worldwide food production and contribute 15% of the world's net revenue explaining the short life expectancy, high infantile mortality, and poor daily caloric intake; moreover, lack of clean drinking water and deficient sanitation promote water-borne infections, diarrhea, and risk of malabsorption that contribute to the prevalence of malnutrition in the tropics. One-third of the world's population consumes insufficient iodine increasing the risk for mental retardation and deafness due to maternal hypothyroidism...
2013: Handbook of Clinical Neurology
R Bellance, M Edimo Nana, M Kone, R Deschamps, A Parry, A Signate, G Panelatti, D Smadja
INTRODUCTION: Neurological involvement associated with copper deficiency has been reported recently in humans and may be under-recognized. CASE REPORT: A 65-year-old patient, with past history of gastrectomy 40 years earlier, developed a myelodysplastic syndrome and then subacute onset of progressive gait ataxia and paresthesias in the lower extremities. Serum vitamin B12 level was low but neurological deterioration persisted, despite vitamin replacement therapy and normal cobalamin level...
August 2010: Revue Neurologique
P Mbelesso, M-L Yogo, E Yangatimbi, V de Paul-Sénékian, N M Nali, P-M Preux
INTRODUCTION: Konzo is a neuromyelopathy characterized by permanent spastic paraparesis, linked to a subacute poisoning by cyanide found in cassava. The purpose of the study is to describe the epidemiological aspects of konzo in health region No. 2 in the Central African Republic. METHOD: A descriptive cross-sectional study was conducted among patients collected during a one-month period (July 16 to August 16, 2007) of active surveillance for acute flaccid paralysis...
May 2009: Revue Neurologique
Philippe V Afonso, Simona Ozden, Marie-Christine Cumont, Danielle Seilhean, Luis Cartier, Payam Rezaie, Sarah Mason, Sophie Lambert, Michel Huerre, Antoine Gessain, Pierre-Olivier Couraud, Claudine Pique, Pierre-Emmanuel Ceccaldi, Ignacio A Romero
The blood-brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown to be disrupted during retroviral-associated neuromyelopathies. Human T Lymphotropic Virus (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a slowly progressive neurodegenerative disease associated with BBB breakdown. The BBB is composed of three cell types: endothelial cells, pericytes and astrocytes. Although astrocytes have been shown to be infected by HTLV-1, until now, little was known about the susceptibility of BBB endothelial cells to HTLV-1 infection and the impact of such an infection on BBB function...
November 2008: PLoS Pathogens
Philippe Vicente Afonso, Simona Ozden, Marie-Christine Prevost, Christine Schmitt, Danielle Seilhean, Babette Weksler, Pierre-Olivier Couraud, Antoine Gessain, Ignacio Andres Romero, Pierre-Emmanuel Ceccaldi
The blood-brain barrier (BBB), which constitutes the interface between blood and cerebral parenchyma, has been shown to be disrupted during retroviral associated neuromyelopathies. Human T cell leukemia virus (HTLV-1)-associated myelopathy/tropical spastic paraparesis is a slowly progressive neurodegenerative disease, in which evidence of BBB breakdown has been demonstrated by the presence of lymphocytic infiltrates in the CNS and plasma protein leakage through cerebral endothelium. Using an in vitro human BBB model, we investigated the cellular and molecular mechanisms involved in endothelial changes induced by HTLV-1-infected lymphocytes...
August 15, 2007: Journal of Immunology: Official Journal of the American Association of Immunologists
Sabine Plancoulaine, Antoine Gessain, Patricia Tortevoye, Anne Boland-Auge, Alexandre Vasilescu, Fumihiko Matsuda, Laurent Abel
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is a human oncoretrovirus causing adult T-cell leukemia/lymphoma and chronic neuromyelopathy. We previously showed by segregation analysis that a dominant gene controls HTLV-1 infection through breast-feeding in children of African origin. Here, we report the mapping of this locus by a genome-wide linkage analysis based on the genetic model provided by segregation analysis. Five pedigrees of African origin with HTLV-1 seropositive children were included in the study...
November 15, 2006: Human Molecular Genetics
Agnon A K Balogou, Eric K Grunitzky, Comlan Kpade, Mofou Belo
To ascertain the aetiology, of non traumatic paraplegia retrospective survey, concerning 2396 patients hospitalised from January 1st 1995 to December 31st 1999, was done. Two hundred forty three cases were founded after investigation. The frequency of non traumatic paraplegia was 10.14%. Peripheral motor neuron's causes were 48.97% (119 cases). In this group, tropical neuromyelopathies were the commonest 65.54% (78 cases) while Guillain Barre syndrome was 3.36% (4 cases). Bones, epidural et meningeal (envelope) causes were 38...
January 2002: La Tunisie Médicale
A Gessain, R Mahieux
GEOGRAPHIC DISTRIBUTION AND TRANSMISSION: HTLV-1 is not an ubiquitous virus. 15 to 25 million subjects are estimated to be infected. Endemic areas are recognized in southern Japan, tropical Africa, the Caribbean, some areas in Central and South America, and in few regions of the Middle East and Melanesia. In these endemic zones, 0.5 to 50% of the population, depending on age and gender, have specific antibodies against HTLV-1 antigens. Interhuman transmission can occur from mother to child by prolonged breast feeding, from men to women by sexual intercourse, and from blood exposure via infected lymphoid cells...
December 23, 2000: La Presse Médicale
A Gessain, R Mahieux
Human T Cell leukemia/lymphoma virus type I, the first human oncogenic retrovirus, is the aetiological factor of Adult T cell leukemia (ATL), a CD4+ malignant lymphoproliferative disease and of a chronic neuromyelopathy, the tropical spastic paraparesis or HTLV-1 associated myelopathy (TSP/HAM). HTLV-1, which infects from 15 to 25 million individuals world-wide, is highly endemic in certain areas such as south-western Japan, Central Africa, the Caribbean basin and some regions of South America, Melanesia and of the middle East (for example the Mashhad area of Iran)...
July 2000: Bulletin de la Société de Pathologie Exotique
S Plancoulaine, A Gessain, M Joubert, P Tortevoye, I Jeanne, A Talarmin, G de Thé, L Abel
Human T lymphotropic virus type I (HTLV-I) is a human oncoretrovirus that causes an adult T cell leukemia/lymphoma and a chronic neuromyelopathy. To investigate whether familial aggregation of HTLV-I infection (as determined by specific seropositive status) could be explained in part by genetic factors, we conducted a large genetic epidemiological survey in an HTLV-I-endemic population of African origin from French Guiana. All of the families in 2 villages were included, representing 83 pedigrees with 1638 subjects, of whom 165 (10...
August 2000: Journal of Infectious Diseases
R M Simpson, T M Zhao, B Schmidt Hubbard, W Said, T J Kindt
Infection with human T cell leukemia virus type I (HTLV-I) is typically asymptomatic, but does result in diverse diseases ranging from adult T cell leukemia to spastic neuromyelopathy. To date, differences in HTLV-I provirus structure have not been correlated with pathogenic or asymptomatic outcome of infection. Molecular clones of HTLV-I are now available and represent a powerful tool to link virus structure to pathogenesis. Present studies to explore in vivo infectivity and pathogenicity of an HTLV-I molecular clone, K30p, have utilized the rabbit as a model system...
May 20, 1998: AIDS Research and Human Retroviruses
C Nicot, T Astier-Gin, B Guillemain
Programmed cell death (PCD) characteristically involves chromatin condensation, membrane blebbing, and DNA oligonucleosomal fragmentation. These events, collectively referred to as apoptosis, represent an active cell suicide mechanism that eliminates cellular threats including potentially cancerous or virus-infected cells. Various types of programmed cell death can be blocked by the proto-oncogene Bcl-2. Levels of this protein are consistently low or undetectable in human endothelial cells (EC), which are important for immunoregulation through their interactions with circulating lymphocytes and are potential targets for infection by virus-bearing T-cells...
September 15, 1997: Virology
S Sainte-Foie, V Bourhis, F Joly, J Petit-Bon
The neurological observations have been reported at André Bouron Hospital of Saint-Laurent du Maroni and at General Hospital of Cayenne during a period of 5 years. All patients belonged to the "Noir Marron" ethnic group and lived in the area of Saint-Laurent. There were six women and four men, aged 15-35 years. Neurological symptoms were isolated or associated to other organ failure. Neurological manifestations included retrobulbar optic neuropathy, spastic paraparesis, sensitive ataxia and cerebellar ataxia, psychiatric symptoms were observed...
1997: Bulletin de la Société de Pathologie Exotique
G de Thé, R Bomford
Endemic infection with the human T cell leukemia/lymphoma viruses I and II (HTLV-I/II) is now recognized to be worldwide, and is becoming epidemic among intravenous drug abusers (IVDAs) in the United States and Europe. The number of people around the world infected with HTLV-I can be estimated as between 10 and 20 million (Table 1). HTLV-I causes a rapidly progressing adult T cell leukemia/lymphoma (ATLL), and an incurable progressive neuromyelopathy named tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM), as well as a number of less well-studied syndromes...
May 1993: AIDS Research and Human Retroviruses
L D Stuart, F W Oehme
No abstract text is available yet for this article.
April 1982: Veterinary and Human Toxicology
H Altenkirch, H M Wagner, G Stoltenburg-Didinger, R Steppat
Hexacarbon-containing solvents can induce specific functional and morphological disorders in the peripheral and central nervous system. The neurological manifestations consist in polyneuropathy syndromes and neuromyelopathies. Such clinical pictures have been observed both after exposure at industrial work and after abuse of hexacarbon-containing solvents as narcotics. An outbreak of neuropathies among solvent-sniffers after denaturation of the hexacarbon-containing solvent with methyl-ethyl-ketone led to the assumption that the neurotoxic properties of n-hexane can be considerably potentiated with methyl-ethyl-ketone...
November 1982: Neurobehavioral Toxicology and Teratology
G Laguardia, H A Defféminis Rospide, E Bastarrica, M Rousso
No abstract text is available yet for this article.
1966: Acta Neurológica Latinoamericana
M Dumas, C Giordano, I P Ndiaye, J Hugon, J M Vallat, T Sonan
Since the beginning of this century, the concept of tropical neuromyelopathy (T. N. M.) was progressively elaborated in tropical areas. This disorder is constituted by three main clinical syndromes (e.g.: polyneuropathy, spastic paraplegia, ataxia). Abnormal clinical, electrophysiological and pathological features, observed in all clinical forms argue in favor of a diffuse pathobiological process of the nervous system. The association with positive HTLV-1 serology, has recently induced a great interest for the spastic forms of T...
1988: Bulletin de la Société de Pathologie Exotique et de Ses Filiales
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