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https://www.readbyqxmd.com/read/29385802/nitric-oxide-delivering-high-density-lipoprotein-like-nanoparticles-as-a-biomimetic-nanotherapy-for-vascular-disease
#1
Jonathan S Rink, Wangqiang Sun, Sol Misener, Jiao-Jing Wang, Zheng Jenny Zhang, Melina R Kibbe, Vinayak P Dravid, Subbu S Venkatraman, C Shad Thaxton
Disorders of blood vessels cause a range of severe health problems. As a powerful vasodilator and cellular second messenger, nitric oxide (NO) is known to have beneficial vascular functions. But NO typically has a short half-life and is not specifically targeted. On the other hand, high-density lipoproteins (HDLs) are targeted natural nanoparticles that transport cholesterol in the systemic circulation, and whose protective effects in vascular homeostasis overlap with those of NO. Evolving the AuNP-templated HDL-like nanoparticles (HDL NPs), a platform of bio-inspired HDL, we set up a targeted biomimetic nanotherapy for vascular disease that combines the functions of NO and HDL...
February 1, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29384601/enhancement-of-the-immune-function-by-titanium-dioxide-nanorods-and-their-application-in-cancer-immunotherapy
#2
Yanli Wang, Chenjie Yao, Lin Ding, Chenchen Li, Jiao Wang, Minghong Wu, Yong Lei
With the rapid development of nanotherapy, concerns surrounding the possible use of nanomaterials-mediated immunomodulation are growing. Thus, evaluating the effects of novel materials for potential application in nanotherapy is essential. Herein, we studied the effects of TiO2-nanorods (NRs) on the immune function and their potential application in immunotherapy. TiO2-NRs exerted specific immunomodulatory effects on the main immune cells. Cytokines TNF-α and IL-2, which play a key role in antitumor processes, were upregulated more significantly than other cytokines (IL-4, IL-5, IFN-γ) in the main immune cells...
April 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29338009/anti-angiogenic-drug-loaded-liposomes-nanotherapy-for-early-atherosclerotic-lesions-in-mice
#3
Isabel Pont, Aracely Calatayud-Pascual, Alicia López-Castellano, Elena P Albelda, Enrique García-España, Luis Martí-Bonmatí, Juan C Frias, M Teresa Albelda
Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.
2018: PloS One
https://www.readbyqxmd.com/read/29334759/redox-nano-architectures-perspectives-and-implications-in-diagnosis-and-treatment-of-human-diseases
#4
Shamim Akhtar Sufi, Sankar Pajaniradje, Victor Mukherjee, Rukkumani Rajagopalan
Significance - Efficient targeted therapy with minimal side effects is the need of the hour.. Locally altered redox state is observed in several human ailments, such as inflammation, sepsis, and cancer. This has been taken advantage in designing redox-responsive nano-drug carriers. Redox-responsive nanosystems open a door to multitude of possibilities for the control of diseases over other drug delivery systems. Recent Advances -The first generation nanotherapy relies on novel properties of nanomaterials to shield the drug and deliver it to the diseased tissue or organ...
January 15, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29313073/correction-to-characterization-of-the-first-fully-human-anti-tem1-scfv-in-models-of-solid-tumor-imaging-and-immunotoxin-based-therapy
#5
Xiaopeng Yuan, Mingjuan Yang, Xiang Chen, Xuhua Zhang, Shrey Sukhadia, Najia Musolino, Huijing Bao, Tingtao Chen, Chen Xu, Qirui Wang, Stephen Santoro, Daniel Ricklin, Jia Hu, Ruihe Lin, Wei Yang, Zhijun Li, Weijun Qin, Aizhi Zhao, Nathalie Scholler, George Coukos
Tumor endothelial marker 1 (TEM1) has been identified as a novel surface marker upregulated on the blood vessels and stroma in many solid tumors. We previously isolated a novel single-chain variable fragment (scFv) 78 against TEM1 from a yeast display scFv library. Here we evaluated the potential applications of scFv78 as a tool for tumor molecular imaging, immunotoxin-based therapy and nanotherapy. Epitope mapping, three-dimensional (3D) structure docking and affinity measurements indicated that scFv78 could bind to both human and murine TEM1, with equivalent affinity, at a well-conserved conformational epitope...
January 8, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29283221/tumor-microenvironment-enabled-nanotherapy
#6
REVIEW
Liying Wang, Minfeng Huo, Yu Chen, Jianlin Shi
Cancer is now one of the world's leading threats to human health. With the development of oncology in both biology and biomedicine, it has been demonstrated that abnormal physiochemical conditions and dysregulated biosynthetic intermediates in tumor microenvironment (TME) play a pivotal role in enabling tumor cells to defend or evade the damage by traditional clinical tumor therapeutics including surgery, chemotherapy, radiotherapy, etc. The fast advances of TME-enabled theranostic nanomedicine have offered promising perspectives, strategies, and approaches for combating cancer based on the novel concept of TME-enabled nanotherapy...
December 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29274774/nanotherapy-for-alzheimer-s-disease-and-vascular-dementia-targeting-senile-endothelium
#7
REVIEW
Joseph S D'Arrigo
Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted "lipid-coated microbubble" [LCM]/"nanoparticle-derived" [ND] (or LCM/ND) nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine...
December 8, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29231126/what-potential-does-plasmonics-amplified-synergistic-immuno-photothermal-nanotherapy-have-for-treatment-of-cancer
#8
Tuan Vo-Dinh, Brant A Inman
No abstract text is available yet for this article.
January 2018: Nanomedicine
https://www.readbyqxmd.com/read/29203413/targeted-magnetic-intra-lysosomal-hyperthermia-produces-lysosomal-reactive-oxygen-species-and-causes-caspase-1-dependent-cell-death
#9
Pascal Clerc, Pauline Jeanjean, Nicolas Hallalli, Michel Gougeon, Bernard Pipy, Julian Carrey, Daniel Fourmy, Véronique Gigoux
Therapeutic strategies using drugs which cause Lysosomal Cell Death have been proposed for eradication of resistant cancer cells. In this context, nanotherapy based on Magnetic Intra-Lysosomal Hyperthermia (MILH) generated by magnetic nanoparticles (MNPs) that are grafted with ligands of receptors overexpressed in tumors appears to be a very promising therapeutic option. However, mechanisms whereby MILH induces cell death are still elusive. Herein, using Gastrin-grafted MNPs specifically delivered to lysosomes of tumor cells from different cancers, we provide evidences that MILH causes cell death through a non-apoptotic signaling pathway...
December 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29149413/tctp-has-a-crucial-role-in-the-different-stages-of-prostate-cancer-malignant-progression
#10
Virginie Baylot, Sara Karaki, Palma Rocchi
Prostate cancer (PC) is the second most common cause of cancer-related mortality in men in the western world after lung cancer. Many patients are not candidates for resection given the advanced stage of their cancer. The primary treatment for advanced PC is the castration therapy which supresses the production of androgens, hormone that promotes PC growth. Despite the efficiency of the castration therapy, most patients develop castration resistant disease which remains uncurable. Clearly, novel approaches are required to effectively treat castration resistant PC (CRPC)...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29071194/prediction-of-anti-cancer-nanotherapy-efficacy-by-imaging
#11
REVIEW
Miles A Miller, Sean Arlauckas, Ralph Weissleder
Anticancer nanotherapeutics have shown mixed results in clinical trials, raising the questions of whether imaging should be used to i) identify patients with a higher likelihood of nanoparticle accumulation, ii) assess nanotherapeutic efficacy before traditional measures show response, and iii) guide adjuvant treatments to enhance therapeutic nanoparticle (TNP) delivery. Here we review the use of a clinically approved MRI nanoparticle (ferumoxytol, FMX) to predict TNP delivery and efficacy. It is becoming increasingly apparent that nanoparticles used for imaging, despite clearly distinct physicochemical properties, often co-localize with TNP in tumors...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29055017/new-generation-nanomedicines-constructed-from-self-assembling-small-molecule-prodrugs-alleviate-cancer-drug-toxicity
#12
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, Penghong Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel (CTX) as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054269/exploiting-enzyme-alterations-in-cancer-for-drug-activation-drug-delivery-and-nanotherapy
#13
Joel Y Hayashi, Fuyuhiko Tamanoi
Alterations of enzyme activity or enzyme levels in cancer tissue have been documented over the years. Taking advantage of these observations, various strategies for drug activation and drug delivery have been developed. One example is a mechanism called "prodrugs" that generates active drugs by enzyme cleavage. Another example is enzyme-induced anticancer drug release mechanisms. This system is constructed by incorporating enzyme-sensitive linkages to materials such as hydrogels and nanodelivery vehicles, including liposomes, polymer micelles, and mesoporous silica nanoparticles...
2017: Enzymes
https://www.readbyqxmd.com/read/28994432/an-intelligent-nir-responsive-chelate-copper-based-anticancer-nanoplatform-for-synergistic-tumor-targeted-chemo-phototherapy
#14
Qianhua Feng, Wanxia Zhang, Yuzhen Li, Xuemei Yang, Yongwei Hao, Hongling Zhang, Wei Li, Lin Hou, Zhenzhong Zhang
The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ions especially Cu(ii) to generate the "activated BLM" for DNA cleavage. Herein, BLM and L-menthol (LM) co-loaded hollow mesoporous Cu2-xS nanoparticles (HMCu2-xS NPs) with surface folic acid (FA) modification were formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targeted chemo-phototherapy. With the tumor targeting ability of the folate receptor (FR)-positive, FA-HMCu2-xS/BLM/LM could pinpoint tumor cells efficiently...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28917821/circulatory-cell-mediated-nanotherapeutic-approaches-in-disease-targeting
#15
Thierry Burnouf, Pierre-Alain Burnouf, Yu-Wen Wu, Er-Yuan Chuang, Long-Sheng Lu, Hadi Goubran
Circulating blood cells, and cell-derived microvesicles, are emerging as pragmatic delivery systems that can smartly complement the already existing nanotherapeutic platforms evaluated to treat or diagnose diseases. The valuable distinctive features of circulatory cells over synthetic nanocarriers encompass their biological origin which confers immune transparence, known biodegradability, high drug loading, relatively long half-life and a targeting capacity associated with their physiological surface functionality...
September 14, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28914952/nanocarriers-for-trail-delivery-driving-trail-back-on-track-for-cancer-therapy
#16
REVIEW
Xu Wu, Shengpeng Wang, Mingxing Li, Anqi Wang, Yangyang Zhou, Peng Li, Yitao Wang
Since its initial identification, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been shown to be capable of selectively inducing apoptosis in cancer cells. However, translation of the encouraging preclinical studies of this cytokine into the clinic has been restricted by its extremely short half-life, the presence of resistant cancer cell populations, and its inefficient in vivo delivery. Recently, there has been exceptional progress in developing novel formulations to increase the circulatory half-life of TRAIL and new combinations to treat cancers that are resistant to TRAIL...
September 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28900513/in-vivo-cancer-cells-elimination-guided-by-aptamer-functionalized-gold-coated-magnetic-nanoparticles-and-controlled-with-low-frequency-alternating-magnetic-field
#17
Irina V Belyanina, Tatiana N Zamay, Galina S Zamay, Sergey S Zamay, Olga S Kolovskaya, Tatiana I Ivanchenko, Valery V Denisenko, Andrey K Kirichenko, Yury E Glazyrin, Irina V Garanzha, Valentina V Grigorieva, Alexandr V Shabanov, Dmitry V Veprintsev, Alexey E Sokolov, Vladimir M Sadovskii, Ana Gargaun, Maxim V Berezovski, Anna S Kichkailo
Biomedical applications of magnetic nanoparticles under the influence of a magnetic field have been proved useful beyond expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various strategies have been suggested to selectively target tumor cancer cells. Our study presents magnetodynamic nanotherapy using DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for selective elimination of tumor cells in vivo...
2017: Theranostics
https://www.readbyqxmd.com/read/28884769/an-experimental-and-computational-framework-for-engineering-multifunctional-nanoparticles-designing-selective-anticancer-therapies
#18
A Aires, J F Cadenas, R Guantes, A L Cortajarena
A key challenge in the treatment of cancer with nanomedicine is to engineer and select nanoparticle formulations that lead to the desired selectivity between tumorigenic and non-tumorigenic cells. To this aim, novel designed nanomaterials, deep biochemical understanding of the mechanisms of interaction between nanomaterials and cells, and computational models are emerging as very useful tools to guide the design of efficient and selective nanotherapies. This works shows, using a combination of detailed experimental approaches and simulations, that the specific targeting of cancer cells in comparison to non-tumorigenic cells can be achieved through the custom design of multivalent nanoparticles...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28868970/the-use-of-nanoparticulates-to-treat-breast-cancer
#19
Xiaomeng Tang, Welley S Loc, Cheng Dong, Gail L Matters, Peter J Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H Adair
Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors...
October 2017: Nanomedicine
https://www.readbyqxmd.com/read/28860754/nanomedicine-applications-in-the-treatment-of-breast-cancer-current-state-of-the-art
#20
REVIEW
Di Wu, Mengjie Si, Hui-Yi Xue, Ho-Lun Wong
Breast cancer is the most common malignant disease in women worldwide, but the current drug therapy is far from optimal as indicated by the high death rate of breast cancer patients. Nanomedicine is a promising alternative for breast cancer treatment. Nanomedicine products such as Doxil(®) and Abraxane(®) have already been extensively used for breast cancer adjuvant therapy with favorable clinical outcomes. However, these products were originally designed for generic anticancer purpose and not specifically for breast cancer treatment...
2017: International Journal of Nanomedicine
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