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microneedling nail

Wing Sin Chiu, Natalie A Belsey, Natalie L Garrett, Julian Moger, Gareth J Price, M BegoƱa Delgado-Charro, Richard H Guy
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail...
December 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
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