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microneedling nail

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https://www.readbyqxmd.com/read/29455257/finite-element-analysis-of-hollow-out-of-plane-hfo-2-microneedles-for-transdermal-drug-delivery-applications
#1
Yong-Hua Zhang, Stephen A Campbell, Sreejith Karthikeyan
Transdermal drug delivery (TDD) based on microneedles is an excellent approach due to its advantages of both traditional transdermal patch and hypodermic syringes. In this paper, the fabrication method of hollow out-of-layer hafnium oxide (HfO2 ) microneedles mainly based on deep reactive ion etching of silicon and atomic layer deposition of HfO2 is described, and the finite element analysis of the microneedles based on ANSYS software is also presented. The fabrication process is simplified by using a single mask...
February 17, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/26478016/drug-delivery-into-microneedle-porated-nails-from-nanoparticle-reservoirs
#2
Wing Sin Chiu, Natalie A Belsey, Natalie L Garrett, Julian Moger, Gareth J Price, M BegoƱa Delgado-Charro, Richard H Guy
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail...
December 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
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