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https://www.readbyqxmd.com/read/29783652/pituitary-gonadal-thyroid-hormones-and-endocrine-disruptors-in-pre-and-postmenopausal-nigerian-women-with-er-pr-and-her-2-positive-and-negative-breast-cancers
#1
Olulope Ajayi, Mabel Charles-Davies, John Anetor, Adeyinka Ademola
Breast cancer is broadly sub-divided into hormone responsive and non-hormone responsive subtypes. Estradiol has been associated with hormone responsive breast cancers. There is, however, a paucity of information on the role of sex hormones, gonadotropins, and thyroid hormone in non-hormone responsive breast cancer. This study aimed to determine differences in the serum levels of sex hormones, gonadotropins, thyroid hormones, and endocrine disruptors (lead, cadmium, and arsenic) in Nigerian women with hormone responsive and non-hormone responsive breast cancers...
May 18, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29751442/the-effect-of-portable-hepa-filter-air-cleaners-on-indoor-pm-2-5-concentrations-and-second-hand-tobacco-smoke-exposure-among-pregnant-women-in-ulaanbaatar-mongolia-the-ugaar-randomized-controlled-trial
#2
Prabjit Barn, Enkhjargal Gombojav, Chimedsuren Ochir, Bayarkhuu Laagan, Bolor Beejin, Gerel Naidan, Buyantushig Boldbaatar, Jargalsaikhan Galsuren, Tsogtbaatar Byambaa, Craig Janes, Patricia A Janssen, Bruce P Lanphear, Tim K Takaro, Scott A Venners, Glenys M Webster, Weiran Yuchi, Christopher D Palmer, Patrick J Parsons, Young Man Roh, Ryan W Allen
BACKGROUND: Portable HEPA filter air cleaners can reduce indoor fine particulate matter (PM2.5 ), but their use has not been adequately evaluated in high pollution settings. We assessed air cleaner effectiveness in reducing indoor residential PM2.5 and second hand smoke (SHS) exposures among non-smoking pregnant women in Ulaanbaatar, Mongolia. METHODS: We randomized 540 participants to an intervention group receiving 1 or 2 HEPA filter air cleaners or a control group receiving no air cleaners...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29723752/prenatal-lead-cadmium-and-mercury-exposure-and-associations-with-motor-skills-at-age-7-years-in-a-uk-observational-birth-cohort
#3
Caroline M Taylor, Alan M Emond, Raghu Lingam, Jean Golding
BACKGROUND: Lead and mercury are freely transferred across the placenta, while cadmium tends to accumulate in the placenta. Each contributes to adverse neurological outcomes for the child. Although prenatal heavy metal exposure has been linked with an array of neurodevelopmental outcomes in childhood, its association with the development of motor skills in children has not been robustly studied. AIMS/OBJECTIVE: The aim of the present study was to investigate the association between prenatal exposure to lead, cadmium and mercury, measured as maternal blood concentrations during pregnancy, and motor skills, measured as subtests of the Movement Assessment Battery for Children (Movement ABC) at age 7 years in a large sample of mother-child pairs enrolled in a UK observational birth cohort study (Avon Longitudinal Study of Parents and Children, ALSPAC)...
April 30, 2018: Environment International
https://www.readbyqxmd.com/read/29703512/urinary-metal-concentrations-among-mothers-and-children-in-a-mexico-city-birth-cohort-study
#4
Ryan C Lewis, John D Meeker, Niladri Basu, Alison M Gauthier, Alejandra Cantoral, Adriana Mercado-García, Karen E Peterson, Martha Maria Téllez-Rojo, Deborah J Watkins
Personal care product use is a potential source of metals exposure among children, but studies have been limited. We measured urinary concentrations of 10 metals (aluminum, arsenic [As], barium [Ba], cadmium, cobalt [Co], lead [Pb], manganese [Mn], molybdenum [Mo], nickel, and zinc [Zn]) in third trimester pregnant women (n = 212) and their children at 8-14 years of age (n = 250). Demographic factors (child sex, age, socioeconomic status, and maternal education), body mass index (BMI) z-score, and child personal care product use in the 24 h prior to urine collection were examined as predictors of urinary metal concentrations...
April 22, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29651732/maternal-cadmium-levels-during-pregnancy-and-the-relationship-with-preeclampsia-and-fetal-biometric-parameters
#5
Fan Wang, Fengyun Fan, Lianyun Wang, Wen Ye, Qiong Zhang, Shuangshuang Xie
Preeclampsia, which is caused by multiple factors, still remains one of the most serious complications of pregnancy. This study was designed to determine cadmium levels in women with preeclampsia compared to those of normotensive women. In this case-control study, maternal blood, umbilical cord blood, and placental cadmium levels were measured by an inductively coupled plasma mass spectrometry system in 51 women presenting consecutively with preeclampsia and 51 normotensive pregnant women. Groups were matched for maternal age, parity, and gestational age...
April 12, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29497997/association-between-chronic-exposure-to-tobacco-smoke-and-accumulation-of-toxic-metals-in-hair-among-pregnant-women
#6
Yibing Zhu, Zhiwen Li, Yiming Pang, Wenhua Huo, Nan Li, Zhenjiang Li, Jingxu Zhang, Rongwei Ye, Bin Wang
Tobacco smoke contains various toxic heavy metals that individuals are exposed to when they smoke. Despite the presence of heavy metals in tobacco smoke, the relationship between smoking and the accumulation of toxic metals in pregnant women after long-term exposure remains under discussion. We examined the association between long-term exposure to tobacco smoke and the accumulation of toxic metals in the hair of female participants. Our study recruited 252 women from the Shanxi and Hebei provinces of Northern China; these participants were self-reported non-active smokers, and had previously delivered healthy babies without birth defects...
March 1, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29479882/cadmium-and-lead-in-women-who-miscarried
#7
Wioleta J Omeljaniuk, Katarzyna Socha, Jolanta Soroczynska, Angelika E Charkiewicz, Tadeusz Laudanski, Marek Kulikowski, Edward Kobylec, Maria H Borawska
BACKGROUND: Cadmium (Cd) and lead (Pb) are toxic elements which, when ingested excessively in food and drinking water, accumulate in selected organs and pass through the placenta barrier to the foetus, showing teratogenic effects. The aim of the study was to determine the concentration of Cd and Pb in blood and placental tissue in women who miscarried. METHODS: The study group consisted of 83 women who miscarried. The control group included 35 women in the first trimester of pregnancy and after childbirth...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29471703/maternal-second-trimester-blood-levels-of-selected-heavy-metals-in-pregnancies-complicated-with-neural-tube-defects
#8
Şule Özel, Sebnem Ozyer, Osman Aykut, Mehmet Çinar, Omer Hınc Yılmaz, Ali Caglar, Yaprak Engin-Ustun
PURPOSE: Neural tube defects (NTDs) are the most common malformations of the central nervous system (CNS). There is continuing research for the identification of risk factors and interventions for prevention of NTDs. The aim of this study was to investigate the maternal second trimester blood levels of selected heavy metals namely, arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), and lead (Pb) and their possible relation with the occurrence of NTDs. METHODS: Twenty-one healthy second trimester pregnant women with fetuses affected with NTD (cases) were matched with 21 healthy pregnant women with unaffected fetuses (controls) with respect to age, body mass index (BMI), and gestational age...
February 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29438954/dietary-intake-and-urinary-metals-among-pregnant-women-in-the-pacific-northwest
#9
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
May 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29425094/cadmium-body-burden-and-gestational-diabetes-mellitus-a-prospective-study
#10
Wenyu Liu, Bin Zhang, Zheng Huang, Xinyun Pan, Xiaomei Chen, Chen Hu, Hongxiu Liu, Yangqian Jiang, Xiaojie Sun, Yang Peng, Wei Xia, Shunqing Xu, Yuanyuan Li
BACKGROUND: Several studies have reported that cadmium (Cd) is associated with type 2 diabetes. However, little is known about Cd exposure and the risk of gestational diabetes mellitus (GDM). OBJECTIVE: We examined the association between Cd body burden in early pregnancy and the risk of GDM. METHODS: We conducted a prospective study of 2,026 pregnant women from a single tertiary medical center between 2013 and 2016 in Wuhan, China. Cd body burden was reflected by Cd concentrations in urine samples collected between gestational weeks 8 and 14...
February 8, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29415948/effect-of-gestational-cadmium-exposure-on-fetal-growth-polyubiquitinated-protein-and-monoubiqutin-levels-in-the-fetal-liver-of-mice
#11
Hisaka Kurita, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Maki Tokumoto, Jin-Yong Lee, Masahiko Satoh
Cadmium (Cd) is an environmental pollutant present in contaminated water, food and soil. Cd adversely affects fetal development. We exposed pregnant mice to daily oral doses of 5 and 10 mg/kg Cd and examined fetal growth. It was demonstrated that the exposure to Cd (10 mg/kg) during gestation caused fetal growth retardation (FGR). Investigation of the ubiquitin-proteasome system in fetal livers of mice exposed to gestational Cd revealed increased polyubiquitinated protein accumulation, contrasting with decreased levels of monoubiquitin protein...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29405962/progesterone-attenuates-hypertension-and-autoantibody-levels-to-the-angiotensin-ii-type-1-receptor-in-response-to-elevated-cadmium-during-pregnancy
#12
Qiong Zhang, Yinping Huang, Keke Zhang, Yan Yan, Jie Wu, Fan Wang, Yuan Zhao, Huifang Xu, Wei Jiang, Danyang Yu, Yongtao Chen, Duyun Ye
INTRODUCTION: Preeclampsia is associated with the presence of pathogenic angiotensin-receptor-activating autoantibodies. Cadmium is an increasingly prevalent environmental pollutant that can mimic oestrogens, which may enhance immunoglobulin production. Progesterone exerts opposite effects to oestrogen. METHODS: We measured the levels of cadmium and progesterone in preeclamptic patients and controls. Pregnant rats exposed to cadmium (0.125 mg/kg body weight) from gestational day 9-12 were treated with/without progesterone (3 mg/kg) beginning from gestational day 9 to delivery...
February 2018: Placenta
https://www.readbyqxmd.com/read/29390543/the-risk-of-missed-abortion-associated-with-the-levels-of-tobacco-heavy-metals-and-phthalate-in-hair-of-pregnant-woman-a-case-control-study-in-chinese-women
#13
Ranran Zhao, Yuelian Wu, Fangfang Zhao, Yingnan Lv, Damin Huang, Jinlian Wei, Chong Ruan, Mingli Huang, Jinghuan Deng, Dongping Huang, Xiaoqiang Qiu
To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373603/n-acetylcysteine-alleviates-cadmium-induced-placental-endoplasmic-reticulum-stress-and-fetal-growth-restriction-in-mice
#14
Min-Yin Guo, Hua Wang, Yuan-Hua Chen, Mi-Zhen Xia, Cheng Zhang, De-Xiang Xu
Cadmium (Cd) is a developmental toxicant that induces fetal growth restriction (FGR). Placental endoplasmic reticulum (ER) stress is associated with FGR. This study investigated the effects of N-acetylcysteine (NAC) on Cd-induced placental ER stress and FGR. Pregnant mice were intraperitoneally injected with CdCl2 daily from gestational day (GD)13 to GD17. As expected, Cd reduced fetal weight and crown-rump length. Cd decreased the internal space of blood vessels in the placental labyrinth layer and inhibited placental cell proliferation...
2018: PloS One
https://www.readbyqxmd.com/read/29338949/relation-between-cadmium-exposure-and-gestational-diabetes-mellitus
#15
Yuling Xing, Wei Xia, Bin Zhang, Aifen Zhou, Zheng Huang, Hongling Zhang, Hongxiu Liu, Yangqian Jiang, Chen Hu, Xiaomei Chen, Shunqing Xu, Yuanyuan Li
BACKGROUND: Cadmium (Cd) has been associated with type 2 diabetes in general population. However, the role of Cd in the occurrence of Gestational diabetes mellitus (GDM) remains unclear. OBJECTIVES: Our study was aimed at investigating whether Cd exposure during pregnancy was associated with increased risk of GDM. METHODS: Cd concentrations were measured in urine samples from 6837 pregnant women in Wuhan, China, from 2012 to 2014. A "modified Poisson" model with a robust error variance was used to examine the association of GDM with continuous natural logarithm (ln) transformed urinary Cd or quartiles of urinary Cd levels...
April 2018: Environment International
https://www.readbyqxmd.com/read/29228828/trace-elements-profiles-of-maternal-blood-umbilical-cord-blood-and-placenta-in-beijing-china
#16
Cui Zhou, Ran Zhang, Xueping Cai, Rong Xiao, Huanling Yu
AIM: Profiles of heavy metals such as chromium (Cr), manganese (Mn), arsenic (As), lead (Pb), and cadmium (Cd), and micronutrients such as ferrum (Fe), copper (Cu), zinc (Zn), and selenium (Se) in maternal and umbilical cord blood clots were investigated for assessing placenta function in the transport of micronutrients or heavy metal pollutants. METHODS: Correlations between contents of elements in the two tissues were also analyzed. RESULTS: Significantly lower levels of Cr, Pb, and Cd in umbilical cord blood clots than in maternal blood clots, and negative relationship between lead levels in maternal and umbilical cord blood (r = -...
December 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29206878/predictors-of-mercury-lead-cadmium-and-antimony-status-in-norwegian-never-pregnant-women-of-fertile-age
#17
Christina Herland Fløtre, Kristin Varsi, Thea Helm, Bjørn Bolann, Anne-Lise Bjørke-Monsen
BACKGROUND: The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern. METHODS: Healthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway...
2017: PloS One
https://www.readbyqxmd.com/read/29162486/cadmium-body-burden-and-pregnancy-induced-hypertension
#18
Hongxiu Liu, Wei Xia, Shunqing Xu, Bin Zhang, Bin Lu, Zheng Huang, Hongling Zhang, Yangqian Jiang, Wenyu Liu, Yang Peng, Xiaojie Sun, Yuanyuan Li
Previous studies provided a strong evidence of the association between environmental exposure to cadmium (Cd) and hypertension in the general population. However, the role of Cd in pregnancy-induced hypertension (PIH) remains unclear. A total of 5429 pregnant women was selected from a birth cohort in Wuhan, China to investigate the association between Cd exposure and risk of PIH. Among them, 199 (3.7%) women were diagnosed with PIH. The Cd concentrations in maternal urine collected at delivery were measured by inductively coupled plasma mass spectrometry...
March 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29099808/prenatal-heavy-metal-exposure-and-adverse-birth-outcomes-in-myanmar-a-birth-cohort-study
#19
Kyi Mar Wai, Ohn Mar, Satoko Kosaka, Mitsutoshi Umemura, Chiho Watanabe
Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester...
November 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28990142/blood-cadmium-concentrations-in-women-with-ectopic-pregnancy
#20
Abdullah Karaer, Gorkem Tuncay, Emrullah Tanrikut, Onur Ozgul
The purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 μg/l (interquartile range [IQR] 0...
October 8, 2017: Biological Trace Element Research
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