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cadmium AND pregnant

Yibing Zhu, Zhiwen Li, Yiming Pang, Wenhua Huo, Nan Li, Zhenjiang Li, Jingxu Zhang, Rongwei Ye, Bin Wang
Tobacco smoke contains various toxic heavy metals that individuals are exposed to when they smoke. Despite the presence of heavy metals in tobacco smoke, the relationship between smoking and the accumulation of toxic metals in pregnant women after long-term exposure remains under discussion. We examined the association between long-term exposure to tobacco smoke and the accumulation of toxic metals in the hair of female participants. Our study recruited 252 women from the Shanxi and Hebei provinces of Northern China; these participants were self-reported non-active smokers, and had previously delivered healthy babies without birth defects...
March 1, 2018: Biological Trace Element Research
Wioleta J Omeljaniuk, Katarzyna Socha, Jolanta Soroczynska, Angelika E Charkiewicz, Tadeusz Laudanski, Marek Kulikowski, Edward Kobylec, Maria H Borawska
BACKGROUND: Cadmium (Cd) and lead (Pb) are toxic elements which, when ingested excessively in food and drinking water, accumulate in selected organs and pass through the placenta barrier to the foetus, showing teratogenic effects. The aim of the study was to determine the concentration of Cd and Pb in blood and placental tissue in women who miscarried. METHODS: The study group consisted of 83 women who miscarried. The control group included 35 women in the first trimester of pregnancy and after childbirth...
January 1, 2018: Clinical Laboratory
Şule Özel, Sebnem Ozyer, Osman Aykut, Mehmet Çinar, Omer Hınc Yılmaz, Ali Caglar, Yaprak Engin-Ustun
PURPOSE: Neural tube defects (NTDs) are the most common malformations of the central nervous system (CNS). There is continuing research for the identification of risk factors and interventions for prevention of NTDs. The aim of this study was to investigate the maternal second trimester blood levels of selected heavy metals namely, arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), and lead (Pb) and their possible relation with the occurrence of NTDs. METHODS: Twenty-one healthy second trimester pregnant women with fetuses affected with NTD (cases) were matched with 21 healthy pregnant women with unaffected fetuses (controls) with respect to age, body mass index (BMI), and gestational age...
February 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
February 10, 2018: Environmental Pollution
Wenyu Liu, Bin Zhang, Zheng Huang, Xinyun Pan, Xiaomei Chen, Chen Hu, Hongxiu Liu, Yangqian Jiang, Xiaojie Sun, Yang Peng, Wei Xia, Shunqing Xu, Yuanyuan Li
BACKGROUND: Several studies have reported that cadmium (Cd) is associated with type 2 diabetes. However, little is known about Cd exposure and the risk of gestational diabetes mellitus (GDM). OBJECTIVE: We examined the association between Cd body burden in early pregnancy and the risk of GDM. METHODS: We conducted a prospective study of 2,026 pregnant women from a single tertiary medical center between 2013 and 2016 in Wuhan, China. Cd body burden was reflected by Cd concentrations in urine samples collected between gestational weeks 8 and 14...
February 8, 2018: Environmental Health Perspectives
Hisaka Kurita, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Maki Tokumoto, Jin-Yong Lee, Masahiko Satoh
Cadmium (Cd) is an environmental pollutant present in contaminated water, food and soil. Cd adversely affects fetal development. We exposed pregnant mice to daily oral doses of 5 and 10 mg/kg Cd and examined fetal growth. It was demonstrated that the exposure to Cd (10 mg/kg) during gestation caused fetal growth retardation (FGR). Investigation of the ubiquitin-proteasome system in fetal livers of mice exposed to gestational Cd revealed increased polyubiquitinated protein accumulation, contrasting with decreased levels of monoubiquitin protein...
2018: Journal of Toxicological Sciences
Qiong Zhang, Yinping Huang, Keke Zhang, Yan Yan, Jie Wu, Fan Wang, Yuan Zhao, Huifang Xu, Wei Jiang, Danyang Yu, Yongtao Chen, Duyun Ye
INTRODUCTION: Preeclampsia is associated with the presence of pathogenic angiotensin-receptor-activating autoantibodies. Cadmium is an increasingly prevalent environmental pollutant that can mimic oestrogens, which may enhance immunoglobulin production. Progesterone exerts opposite effects to oestrogen. METHODS: We measured the levels of cadmium and progesterone in preeclamptic patients and controls. Pregnant rats exposed to cadmium (0.125 mg/kg body weight) from gestational day 9-12 were treated with/without progesterone (3 mg/kg) beginning from gestational day 9 to delivery...
February 2018: Placenta
Ranran Zhao, Yuelian Wu, Fangfang Zhao, Yingnan Lv, Damin Huang, Jinlian Wei, Chong Ruan, Mingli Huang, Jinghuan Deng, Dongping Huang, Xiaoqiang Qiu
To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants...
December 2017: Medicine (Baltimore)
Min-Yin Guo, Hua Wang, Yuan-Hua Chen, Mi-Zhen Xia, Cheng Zhang, De-Xiang Xu
Cadmium (Cd) is a developmental toxicant that induces fetal growth restriction (FGR). Placental endoplasmic reticulum (ER) stress is associated with FGR. This study investigated the effects of N-acetylcysteine (NAC) on Cd-induced placental ER stress and FGR. Pregnant mice were intraperitoneally injected with CdCl2 daily from gestational day (GD)13 to GD17. As expected, Cd reduced fetal weight and crown-rump length. Cd decreased the internal space of blood vessels in the placental labyrinth layer and inhibited placental cell proliferation...
2018: PloS One
Yuling Xing, Wei Xia, Bin Zhang, Aifen Zhou, Zheng Huang, Hongling Zhang, Hongxiu Liu, Yangqian Jiang, Chen Hu, Xiaomei Chen, Shunqing Xu, Yuanyuan Li
BACKGROUND: Cadmium (Cd) has been associated with type 2 diabetes in general population. However, the role of Cd in the occurrence of Gestational diabetes mellitus (GDM) remains unclear. OBJECTIVES: Our study was aimed at investigating whether Cd exposure during pregnancy was associated with increased risk of GDM. METHODS: Cd concentrations were measured in urine samples from 6837 pregnant women in Wuhan, China, from 2012 to 2014. A "modified Poisson" model with a robust error variance was used to examine the association of GDM with continuous natural logarithm (ln) transformed urinary Cd or quartiles of urinary Cd levels...
January 12, 2018: Environment International
Cui Zhou, Ran Zhang, Xueping Cai, Rong Xiao, Huanling Yu
AIM: Profiles of heavy metals such as chromium (Cr), manganese (Mn), arsenic (As), lead (Pb), and cadmium (Cd), and micronutrients such as ferrum (Fe), copper (Cu), zinc (Zn), and selenium (Se) in maternal and umbilical cord blood clots were investigated for assessing placenta function in the transport of micronutrients or heavy metal pollutants. METHODS: Correlations between contents of elements in the two tissues were also analyzed. RESULTS: Significantly lower levels of Cr, Pb, and Cd in umbilical cord blood clots than in maternal blood clots, and negative relationship between lead levels in maternal and umbilical cord blood (r = -...
December 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
Christina Herland Fløtre, Kristin Varsi, Thea Helm, Bjørn Bolann, Anne-Lise Bjørke-Monsen
BACKGROUND: The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern. METHODS: Healthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway...
2017: PloS One
Hongxiu Liu, Wei Xia, Shunqing Xu, Bin Zhang, Bin Lu, Zheng Huang, Hongling Zhang, Yangqian Jiang, Wenyu Liu, Yang Peng, Xiaojie Sun, Yuanyuan Li
Previous studies provided a strong evidence of the association between environmental exposure to cadmium (Cd) and hypertension in the general population. However, the role of Cd in pregnancy-induced hypertension (PIH) remains unclear. A total of 5429 pregnant women was selected from a birth cohort in Wuhan, China to investigate the association between Cd exposure and risk of PIH. Among them, 199 (3.7%) women were diagnosed with PIH. The Cd concentrations in maternal urine collected at delivery were measured by inductively coupled plasma mass spectrometry...
November 18, 2017: International Journal of Hygiene and Environmental Health
Kyi Mar Wai, Ohn Mar, Satoko Kosaka, Mitsutoshi Umemura, Chiho Watanabe
Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester...
November 3, 2017: International Journal of Environmental Research and Public Health
Abdullah Karaer, Gorkem Tuncay, Emrullah Tanrikut, Onur Ozgul
The purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 μg/l (interquartile range [IQR] 0...
October 8, 2017: Biological Trace Element Research
Roger Figueroa, Diana Caicedo, Ghisliane Echeverry, Miguel Peña, Fabián Méndez
INTRODUCTION: Global increase in food and water pollution is associated with health risk, which depends on the concentration, the dose, and the exposure time. This has raised concerns about the possible long-term effects of chronic exposure to low concentrations of heavy metals, such as lead, cadmium and mercury. OBJECTIVE: To explore the relationship among socioeconomic status, eating patterns, and exposure to heavy metals among a population of women in Cali, Colombia...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
Iman Al-Saleh, Mai Abduljabbar
The levels of heavy metals (lead, cadmium, methylmercury and arsenic) were determined in 37 brands of imported rice commonly consumed in Saudi Arabia after soaking and rinsing with water, and their potential health risks to residents were estimated by three indices: hazard quotient (HQ), hazard index (HI) and cancer risk (CR). The mean levels of lead, cadmium, methylmercury and total arsenic in soaked (rinsed) rice grains were 0.034 (0.057), 0.015 (0.027), 0.004 (0.007) and 0.202 (0.183) μg/g dry weight, respectively...
October 2017: International Journal of Hygiene and Environmental Health
Shimaa M Motawei, Hossam E Gouda
No abstract text is available yet for this article.
July 31, 2017: Biological Trace Element Research
Hyungmin Lee, Hyewon Park, Eunhee Ha, Yun-Chul Hong, Mina Ha, Hyesook Park, Bung-Nyun Kim, Soo-Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Kyoung Sook Jeong, Yangho Kim
The objective of this study was to investigate stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood in Korean children. This research is part of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center prospective birth cohort study of pregnant women in Korea who were recruited from 2006 to 2010. We analyzed the complete follow-up data of children who were 5years-old in 2016. We measured lead, mercury, and cadmium levels in the umbilical cord blood of 251 children, and analyzed them, for whom neurodevelopmental data were available...
December 31, 2017: Science of the Total Environment
Kyoung Sook Jeong, Eunhee Ha, Ji Young Shin, Hyesook Park, Yun-Chul Hong, Mina Ha, Suejin Kim, Soo-Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Yangho Kim
The present study assessed the associations of heavy metal concentrations in pregnant women with the concentrations in their children during early childhood. This study is a part of the Mothers' and Children's Environmental Health (MOCEH) study, a Korean multi-center prospective birth cohort study of 1751 pregnant women who were recruited from 2006 to 2010. We completed the follow-up of children who were 5years-old in 2016. Lead, total mercury, and cadmium were measured in women during early and late pregnancy, in cord blood, and in children who were 2, 3, and 5years-old...
December 15, 2017: Science of the Total Environment
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