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Artur Iuri Alves de Sousa, Vitor Laerte Pinto
OBJECTIVE: to identify areas with greater risk of AIDS transmission in Brazil. METHODS: this is an ecological study involving georeference of AIDS cases incidence, prevalence and density in Brazilian municipalities using the Kernel method for the periods 1996-1999, 2000-2003, 2004-2007 and 2008-2011. RESULTS: 633,512 AIDS cases were reported between 1996-2011; between 2008-2011, there was increased risk of AIDS transmission in Recife-João Pessoa region, the emergence of areas with average density in the regions of Belém, São Luís, Maceió, Aracaju and Salvador, and a decline in the intensity of risk in São Paulo, Campinas and Ribeirão Preto; prevalence rates were most concentrated in the Southeast, South and Midwest regions of the country...
July 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Iuri Vicente Camargo Morkis, Mariela Granero Farias, Luciana Scotti
INTRODUCTION: The immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content. They are considered early indicators of bone marrow recovery. OBJECTIVE: The aim of this study was to determine the reference ranges for the immature platelet and reticulocyte fractions of hematologically normal individuals in a university hospital. METHODS: Venous blood samples collected in ethylenediaminetetraacetic acid K3 were analyzed using a Sysmex XE-5000™ analyzer...
October 2016: Revista Brasileira de Hematologia e Hemoterapia
Antonella Castagna, Laura Monno, Stefania Carta, Laura Galli, Stefania Carrara, Valentina Fedele, Grazia Punzi, Iuri Fanti, Pietro Caramello, Alessandro Cozzi Lepri, Andrea De Luca, Francesca Ceccherini-Silberstein, Antonella d'Arminio Monforte
Dynamics of human immunodeficiency virus type 1 (HIV-1) tropism after antiretroviral therapy (ART) initiation and their association with disease progression are poorly investigated.This was a cohort study on subjects from the ICONA cohort receiving ART with persistently detectable (PD) or persistently undetectable (PU) viral load (VL) and with stored plasma or peripheral blood mononuclear cell (PBMC) samples at 2 time-points (T1, T2) after ART initiation. HIV-1 co-receptor tropism was determined by V3-loop sequencing and the geno2pheno algorithm...
November 2016: Medicine (Baltimore)
Íngara Keisle São Paulo Barretto Miranda, Anderson Fontes Suzart Miranda, Fernanda Vidigal Duarte Souza, Marcos André Vannier-Santos, Carlos Priminho Pirovani, Iuri Muniz Pepe, Ivanoé João Rodowanski, Katiúcia Tícila de Souza Eduvirgens Ferreira, Luciano Mendes Souza Vaz, Sandra Aparecida de Assis
The current study aims to extract bromelain from different parts (stem, crown, peels, pulp and leaves) of Ananas comosus var. comosus AGB 772; to determine of optimum pH and temperature; to test bromelain stability in disodium EDTA and sodium benzoate, and to investigate its pharmacological activity on B16F10 murine melanoma cells in vitro. The highest enzymatic activity was found in bromelain extracted from the pulp and peel. The optimum bromelain pH among all studied pineapple parts was 6.0. The optimum temperature was above 50 °C in all bromelain extracts...
November 17, 2016: International Journal of Food Sciences and Nutrition
Artur Iuri Alves de Sousa, Vitor Laerte Pinto
Objectives: To estimate the human immunodeficiency virus (HIV) viral load in the Brazilian population and to assess the potential impact of highly active antiretroviral therapy (HAART) in reducing new infections to build evidences and to gather information to support health policies. Methods: Spatial analysis and modeling tools were used to describe the existing patterns of the viral load density, using the Kernel method. Data on viral load and treatment were retrieved from the databases Laboratory Tests Control System (SISCEL), which contains information on the individual's history of viral load, and Medication Logistics Control System (SICLOM), which controls the dispensing of drugs used for antiretroviral therapy...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
Introduction: The use of secondary data for health service research has been increasingly common, having the advantage of acquiring information faster and cheaper, in addition to its larger population, temporal and geographical amplitude. Objectives: The aim of this study was to describe problems in the quality of information about hospitals characteristics and hospitalizations in Brazil. Methods: The National Database on Health Units (CNES), the Public Hospital Information System (SIH), and the Private Hospital Information System (CIH) were analyzed...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Nádia Cristina Pinheiro Rodrigues, Valéria Teresa Saraiva Lino, Regina Paiva Daumas, Mônica Kramer de Noronha Andrade, Gisele O'Dwyer, Denise Leite Maia Monteiro, Alyssa Gerardi, Gabriel Henrique Barroso Viana Fernandes, José Augusto Sapienza Ramos, Carlos Eduardo Gonçalves Ferreira, Iuri da Costa Leite
BACKGROUND: In Brazil, the incidence of dengue greatly increased in the last two decades and there are several factors impeding the control of the disease. The present study focused on describing the space-time evolution of dengue in Brazil from 2001 to 2012 and analyzing the relationship of the reported cases with socio-demographic and environmental factors. METHODS: The analytic units used in the preparation of thematic maps were municipalities. Statistical tests and multilevel regression models were used to evaluate the association between dengue incidence and the following factors: climate, diagnostic period, demographic density, percentage of people living in rural areas, Gross Domestic Product, Gini index, percentage of garbage collection and the rate of households with a sewage network...
2016: PloS One
Rogério da Rosa Gerbatin, Gustavo Cassol, Fernando Dobrachinski, Ana Paula O Ferreira, Caroline B Quines, Iuri D Della Pace, Guilherme L Busanello, Jessié M Gutierres, Cristina W Nogueira, Mauro S Oliveira, Félix A Soares, Vera M Morsch, Michele R Fighera, Luiz Fernando F Royes
Traumatic brain injury (TBI) is one of the most common types of brain injuries that cause death or persistent neurological disturbances in survivors. Most of the promising experimental drugs were not effective in clinical trials; therefore, the development of TBI drugs represents a huge unmet need. Guanosine, an endogenous neuroprotective nucleoside, has not been evaluated in TBI to the best of our knowledge. Therefore, the present study evaluated the effect of guanosine on TBI-induced neurological damage. Our findings showed that a single dose of guanosine (7...
November 9, 2016: Molecular Neurobiology
Iúri Frias, Ana Rute Neves, Marina Pinheiro, Salette Reis
Green tea is manufactured from the leaves of Camellia sinensis and has been shown to possess, among other properties, anticancer, antiobesity, antiatherosclerotic, antidiabetic, antibacterial, and antiviral effects. The beneficial effects of green tea are related to the activities of (-)-epigallocatechin gallate (EGCG). This catechin is very unstable, undergoing degradation and epimerization, which is responsible for the loss of its health benefits. Encapsulation in nanoparticles (NPs) is an effective method to protect EGCG from adverse environmental conditions...
2016: Drug Design, Development and Therapy
Gianina Teribele Venturin, Samuel Greggio, Gabriele Zanirati, Daniel Rodrigo Marinowic, Iuri Marques de Oliveira, João Antonio Pêgas Henriques, Jaderson Costa DaCosta
Cell-based therapy provides a novel strategy to restore lost neurons or modulate the degenerating microenvironment in amyotrophic lateral sclerosis (ALS). This study verified the therapeutic potential of bone marrow mononuclear cells (BMMCs) in SOD1(G93A) mice. BMMCs were obtained from enhanced green fluorescent protein (EGFP) transgenic C57BL/6 mice ((EGFP)BMMCs) or from SOD1(G93A) transgenic mice ((mSOD1)BMMCs) and given to mice at the pre-symptomatic or late symptomatic stage. Survival, body weight and motor performance data were recorded...
October 28, 2016: Neuroscience Letters
Marcelo A Sulzbacher, Tine Grebenc, Tiara S Cabral, Admir J Giachini, Bruno T Goto, Matthew E Smith, Iuri G Baseia
Restingomyces reticulatus gen. et sp. nov. is a recently discovered false truffle species from Atlantic "restinga" rainforest in northeastern Brazil. Molecular and morphological characters separate this new sequestrate species from other described taxa in the order Phallales (Phallomycetidae, Basidiomycota). In our phylogenetic analysis based on nuc 28S rDNA and atp6, R. reticulatus forms a sister clade to Trappea darkeri and Phallobata alba, with the three taxa forming the earliest diverging lineage within Phallales...
September 2016: Mycologia
Karine Maria Martins Bezerra Carvalho, Tiago Sousa de Melo, Karina Moura de Melo, Ana Luiza Gomes Quinderé, Francisca Tuelly Bandeira de Oliveira, Ana Flávia Seraine Custódio Viana, Paulo Iury Gomes Nunes, Josiane da Silva Quetz, Daniel de Araújo Viana, Armenio André de Carvalho Almeida da Silva, Alexandre Havt, Said Gonçalves da Cruz Fonseca, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos
Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum, on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either α,β-amyrin (10 or 20 mg/kg) or sibutramine (10 mg/kg) for 15 weeks. Variables measured at termination were body weight, visceral fat accumulation, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions in adipose tissue, the levels of plasma glucose and insulin, the satiety hormones ghrelin and leptin, the digestive enzymes amylase and lipase, and the inflammatory mediators TNF-α, interleukin-6, and MCP-1...
August 15, 2016: Planta Medica
Bruno Mendonça Protásio, Adriana Matutino, Liana Valente Lage, Iuri Santana, Ricardo Ramos, Jorge Sabbaga, Fernanda Capareli, Daniel Saragiotto, Rachel Riechelmann, Paulo M Hoff
BACKGROUND: The efficacy and safety of the combination of a fluoropyrimidine with oxaliplatin for patients with stage III colorectal cancer (CRC) have been evaluated in selected patients who took part in clinical trials. We evaluated the outcomes of FLOX (bolus fluorouracil [5-FU] combined with oxaliplatin) in patients with resected stage III CRC treated in the community in a large cancer center. PATIENTS AND METHODS: We performed a retrospective unicenter cohort study of all consecutive stage III CRC patients who received adjuvant chemotherapy with an mFLOX (modified FLOX) regimen...
July 19, 2016: Clinical Colorectal Cancer
Iuri Zappi, Hassan Ghahari
Species diversity of Iranian Cleridae (Coleoptera: Cleroidea) is summarized in this paper. A total of 48 species and 1 subspecies in 14 genera belonging to 4 subfamilies of Cleridae are recorded. Eight species, Thaneroclerus buqueti (Lefebvre, 1835), Denops albofasciatus (Charpentier, 1825), Flabellotilloidea palaestina (Pic, 1900), Clerus mutillaroides Reitter, 1894, Opilo cilicicus Hintz, 1902, Opilo longipilis Fairmaire, 1892, Trichodes alberi Escherich, 1894 and Trichodes inermis Reitter, 1894 are recorded from Iran for the first time...
2016: Zootaxa
Gabriel Ferreira Nicoloso, Iuri Silveira dos Santos, Jorge Abel Flores, Bruno Lopes da Silveira, Marta Dutra Machado Oliveira
Ankyloglossia entails short lingual frenum, impairing satisfactory tongue movement and leading to problems related to deglutition, feeding and diction. This clinical report uses laser technology, rather than traditional surgical procedure with scalpel, to perform a lingual frenulotomy on a 9-year old child diagnosed with ankyloglossia, aiming to investigate more conservative and less traumatic dental procedures. Due to the many advantages of the laser device, such as bloodless surgical field, absence of sutures, minimal swelling and post-surgical pain, the high intensity diode laser is a viable alternative technique in soft tissue surgeries...
2016: Journal of Clinical Pediatric Dentistry
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
OBJECTIVE: To analyze if the adjusted hospital mortality varies according to source of payment of hospital admissions, legal nature, and financing settlement of hospitals. METHODS: Cros-ssectional study with information source in administrative databases. Specific hospital admission reasons were selected considering the volume of hospital admissions and the list of quality indicators proposed by the North-American Agency for Healthcare Research and Quality (AHRQ)...
July 21, 2016: Revista de Saúde Pública
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
In Brazil, the combined presence of public and private interests in financing and provision of healthcare services stands out clearly in hospital care. Financing arrangements adopted by hospitals (the public Brazilian Unified National Health System - SUS and/or health plans and/or out-of-pocket payment) can affect quality of care. Studies have analyzed the hospital standardized mortality ratio (HSMR) in relation to quality improvements. The objective was to analyze HSMR according to source of payment for the hospitalization and the hospital's financing arrangement...
July 21, 2016: Cadernos de Saúde Pública
Mattia Prosperi, Iain Buchan, Iuri Fanti, Sandro Meloni, Pietro Palladino, Vetle I Torvik
Family background-kinship-can propagate careers. The evidence for academic nepotism is littered with complex associations and disputed causal inferences. Surname clustering, albeit with very careful consideration of surnames' flows across regions and time periods, can be used to reflect family ties. We examined surname patterns in the health science literature, by country, across five decades. Over 21 million papers indexed in the MEDLINE/PubMed database were analyzed. We identified relevant country-specific kinship trends over time and found that authors who are part of a kin tend to occupy central positions in their collaborative networks...
August 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
Thaiomara A Silva, Basílio Smuczek, Iuri C Valadão, Luciana M Dzik, Rebeca P Iglesia, Mário C Cruz, André Zelanis, Adriane S de Siqueira, Solange M T Serrano, Gary S Goldberg, Ruy G Jaeger, Vanessa M Freitas
Extracellular vesicles play important roles in tumor development. Many components of these structures, including microvesicles and exosomes, have been defined. However, mechanisms by which extracellular vesicles affect tumor progression are not fully understood. Here, we investigated vesicular communication between mammary carcinoma cells and neighboring nontransformed mammary fibroblasts. Nonbiased proteomic analysis found that over 1% of the entire proteome is represented in these vesicles, with the neuroblast differentiation associated protein AHNAK and annexin A2 being the most abundant...
June 27, 2016: Oncotarget
Iuri Marinov, Andrea J Illingworth, Miroslav Benko, D Robert Sutherland
BACKGROUND: CD157 has been recently reported as a useful glycosylphosphatidylinositol (GPI)-linked marker for the detection of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with suspected paroxysmal nocturnal hemoglobinuria by flow cytometry as it targets both neutrophils and monocytes. The aim of this study is to test the feasibility of a non-fluorescent aerolysin (FLAER) approach and propose an alternative for laboratories, where FLAER is not available. METHODS: We validated a non-FLAER-based single-tube, 6-color assay targeting the GPI-linked structures CD157, CD24, and CD14...
June 13, 2016: Cytometry. Part B, Clinical Cytometry
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