Read by QxMD icon Read


Gianina Teribele Venturin, Samuel Greggio, Gabriele Zanirati, Daniel Rodrigo Marinowic, Iuri Marques de Oliveira, João Antonio Pêgas Henriques, Jaderson Costa DaCosta
Cell-based therapy provides a novel strategy to restore lost neurons or modulate the degenerating microenvironment in amyotrophic lateral sclerosis (ALS). This study verified the therapeutic potential of bone marrow mononuclear cells (BMMCs) in SOD1(G93A) mice. BMMCs were obtained from enhanced green fluorescent protein (EGFP) transgenic C57BL/6 mice ((EGFP)BMMCs) or from SOD1(G93A) transgenic mice ((mSOD1)BMMCs) and given to mice at the pre-symptomatic or late symptomatic stage. Survival, body weight and motor performance data were recorded...
September 22, 2016: Neuroscience Letters
Marcelo A Sulzbacher, Tine Grebenc, Tiara S Cabral, Admir J Giachini, Bruno T Goto, Matthew E Smith, Iuri G Baseia
Restingomyces reticulatus gen. et sp. nov. is a recently discovered false truffle species from Atlantic "restinga" rainforest in northeastern Brazil. Molecular and morphological characters separate this new sequestrate species from other described taxa in the order Phallales (Phallomycetidae, Basidiomycota). In our phylogenetic analysis based on nuc 28S rDNA and atp6, R. reticulatus forms a sister clade to Trappea darkeri and Phallobata alba, with the three taxa forming the earliest diverging lineage within Phallales...
September 2016: Mycologia
Karine Maria Martins Bezerra Carvalho, Tiago Sousa de Melo, Karina Moura de Melo, Ana Luiza Gomes Quinderé, Francisca Tuelly Bandeira de Oliveira, Ana Flávia Seraine Custódio Viana, Paulo Iury Gomes Nunes, Josiane da Silva Quetz, Daniel de Araújo Viana, Armenio André de Carvalho Almeida da Silva, Alexandre Havt, Said Gonçalves da Cruz Fonseca, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos
Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum, on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either α,β-amyrin (10 or 20 mg/kg) or sibutramine (10 mg/kg) for 15 weeks. Variables measured at termination were body weight, visceral fat accumulation, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions in adipose tissue, the levels of plasma glucose and insulin, the satiety hormones ghrelin and leptin, the digestive enzymes amylase and lipase, and the inflammatory mediators TNF-α, interleukin-6, and MCP-1...
August 15, 2016: Planta Medica
Bruno Mendonça Protásio, Adriana Matutino, Liana Valente Lage, Iuri Santana, Ricardo Ramos, Jorge Sabbaga, Fernanda Capareli, Daniel Saragiotto, Rachel Riechelmann, Paulo M Hoff
BACKGROUND: The efficacy and safety of the combination of a fluoropyrimidine with oxaliplatin for patients with stage III colorectal cancer (CRC) have been evaluated in selected patients who took part in clinical trials. We evaluated the outcomes of FLOX (bolus fluorouracil [5-FU] combined with oxaliplatin) in patients with resected stage III CRC treated in the community in a large cancer center. PATIENTS AND METHODS: We performed a retrospective unicenter cohort study of all consecutive stage III CRC patients who received adjuvant chemotherapy with an mFLOX (modified FLOX) regimen...
July 19, 2016: Clinical Colorectal Cancer
Iuri Zappi, Hassan Ghahari
Species diversity of Iranian Cleridae (Coleoptera: Cleroidea) is summarized in this paper. A total of 48 species and 1 subspecies in 14 genera belonging to 4 subfamilies of Cleridae are recorded. Eight species, Thaneroclerus buqueti (Lefebvre, 1835), Denops albofasciatus (Charpentier, 1825), Flabellotilloidea palaestina (Pic, 1900), Clerus mutillaroides Reitter, 1894, Opilo cilicicus Hintz, 1902, Opilo longipilis Fairmaire, 1892, Trichodes alberi Escherich, 1894 and Trichodes inermis Reitter, 1894 are recorded from Iran for the first time...
2016: Zootaxa
Gabriel Ferreira Nicoloso, Iuri Silveira dos Santos, Jorge Abel Flores, Bruno Lopes da Silveira, Marta Dutra Machado Oliveira
Ankyloglossia entails short lingual frenum, impairing satisfactory tongue movement and leading to problems related to deglutition, feeding and diction. This clinical report uses laser technology, rather than traditional surgical procedure with scalpel, to perform a lingual frenulotomy on a 9-year old child diagnosed with ankyloglossia, aiming to investigate more conservative and less traumatic dental procedures. Due to the many advantages of the laser device, such as bloodless surgical field, absence of sutures, minimal swelling and post-surgical pain, the high intensity diode laser is a viable alternative technique in soft tissue surgeries...
2016: Journal of Clinical Pediatric Dentistry
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
OBJECTIVE: To analyze if the adjusted hospital mortality varies according to source of payment of hospital admissions, legal nature, and financing settlement of hospitals. METHODS: Cros-ssectional study with information source in administrative databases. Specific hospital admission reasons were selected considering the volume of hospital admissions and the list of quality indicators proposed by the North-American Agency for Healthcare Research and Quality (AHRQ)...
July 21, 2016: Revista de Saúde Pública
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
In Brazil, the combined presence of public and private interests in financing and provision of healthcare services stands out clearly in hospital care. Financing arrangements adopted by hospitals (the public Brazilian Unified National Health System - SUS and/or health plans and/or out-of-pocket payment) can affect quality of care. Studies have analyzed the hospital standardized mortality ratio (HSMR) in relation to quality improvements. The objective was to analyze HSMR according to source of payment for the hospitalization and the hospital's financing arrangement...
July 21, 2016: Cadernos de Saúde Pública
Mattia Prosperi, Iain Buchan, Iuri Fanti, Sandro Meloni, Pietro Palladino, Vetle I Torvik
Family background-kinship-can propagate careers. The evidence for academic nepotism is littered with complex associations and disputed causal inferences. Surname clustering, albeit with very careful consideration of surnames' flows across regions and time periods, can be used to reflect family ties. We examined surname patterns in the health science literature, by country, across five decades. Over 21 million papers indexed in the MEDLINE/PubMed database were analyzed. We identified relevant country-specific kinship trends over time and found that authors who are part of a kin tend to occupy central positions in their collaborative networks...
August 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
Thaiomara A Silva, Basílio Smuczek, Iuri C Valadão, Luciana M Dzik, Rebeca P Iglesia, Mário C Cruz, André Zelanis, Adriane S de Siqueira, Solange M T Serrano, Gary S Goldberg, Ruy G Jaeger, Vanessa M Freitas
Extracellular vesicles play important roles in tumor development. Many components of these structures, including microvesicles and exosomes, have been defined. However, mechanisms by which extracellular vesicles affect tumor progression are not fully understood. Here, we investigated vesicular communication between mammary carcinoma cells and neighboring nontransformed mammary fibroblasts. Nonbiased proteomic analysis found that over 1% of the entire proteome is represented in these vesicles, with the neuroblast differentiation associated protein AHNAK and annexin A2 being the most abundant...
June 27, 2016: Oncotarget
Iuri Marinov, Andrea J Illingworth, Miroslav Benko, D Robert Sutherland
BACKGROUND: CD157 has been recently reported as a useful glycosylphosphatidylinositol (GPI)-linked marker for the detection of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with suspected paroxysmal nocturnal hemoglobinuria by flow cytometry as it targets both neutrophils and monocytes. The aim of this study is to test the feasibility of a non-fluorescent aerolysin (FLAER) approach and propose an alternative for laboratories, where FLAER is not available. METHODS: We validated a non-FLAER-based single-tube, 6-color assay targeting the GPI-linked structures CD157, CD24, and CD14...
June 13, 2016: Cytometry. Part B, Clinical Cytometry
Ana Flávia Seraine Custódio Viana, Francilene Vieira da Silva, Hélio de Barros Fernandes, Irisdalva Sousa Oliveira, Milena Aguiar Braga, Paulo Iury Gomes Nunes, Daniel de Araújo Viana, Damião Pergentino de Sousa, Vietla Satyanarayana Rao, Rita de Cássia Meneses Oliveira, Flávia Almeida Santos
OBJECTIVES: (-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s). METHODS: Gastroprotective activity of (-)-myrtenol was evaluated using the mouse model of ethanol-induced gastric damage. To elucidate the gastroprotective mechanism(s), the roles of GABA, prostaglandins, nitric oxide and KATP channels were assessed...
August 2016: Journal of Pharmacy and Pharmacology
Tales Iuri Paz E Albuquerque, Ronice Maria Pereira Franco de Sá, José Luiz do Amaral Correia de Araújo
The "new" National Health Promotion Policy opens up prospects and challenges for the political arena. This is the space where agreements and disagreements relating to decision-making, which will underpin its implementation, are established. This study sought to understand these questions, seeking to reflect upon the formation of arenas, in order to contribute with strategies coherent with the policy. It is a qualitative study, based on the theory of justification and its 'polities' according to Boltanski and Thévenot...
June 2016: Ciência & Saúde Coletiva
Joseph W LaMattina, Nicholas D Keul, Pierre Reitzer, Suraj Kapoor, Felipe Galzerani, Daniel J Koch, Iuri E Gouvea, William N Lanzilotta
Glycyl radical enzymes (GREs) represent a diverse superfamily of enzymes that utilize a radical mechanism to catalyze difficult, but often essential, chemical reactions. In this work we present the first biochemical and structural data for a GRE-type diol dehydratase from the organism Roseburia inulinivorans (RiDD). Despite high sequence (48% identity) and structural similarity to the GRE-type glycerol dehydratase from Clostridium butyricum, we demonstrate that the RiDD is in fact a diol dehydratase. In addition, the RiDD will utilize both (S)-1,2-propanediol and (R)-1,2-propanediol as a substrate, with an observed preference for the S enantiomer...
July 22, 2016: Journal of Biological Chemistry
Luis Reinoso-Barbero, Ramón Díaz-Garrido, Miguel Fernández-Fernández, Ana Capapé-Aguilar, Carmen Romero-Paredes, María-José Aguado-Benedí
Occupational physicians should be familiar with the risk factors and clinical presentation of pulmonary thromboembolism (PTE). PTE belongs to the group ofis a cardiovascular diseases, which are the main cause (40%) of death in Spanish workplaces; at present, they may be considered a work-related injury because of the doctrinal evolution in the legal interpretation of the presumption of iuris tantum. We present the case of a hypertensive and obese adult male who suffered a PTE at his workplace. The availability of a portable pulse oximeter (room air SpO2, 92%) was critical in guiding the decision to refer him urgently to the hospital, where the diagnosis was confirmed...
July 2015: Archivos de Prevención de Riesgos Laborales
Vaclava Polivkova, Peter Rohon, Hana Klamova, Olga Cerna, Martina Divoka, Nikola Curik, Jan Zach, Martin Novak, Iuri Marinov, Simona Soverini, Edgar Faber, Katerina Machova Polakova
Bone marrow transplantation or ponatinib treatment are currently recommended strategies for management of patients with chronic myeloid leukemia (CML) harboring the T315I mutation and compound or polyclonal mutations. However, in some individual cases, these treatment scenarios cannot be applied. We used an alternative treatment strategy with interferon-α (IFN-α) given solo, sequentially or together with TKI in a group of 6 cases of high risk CML patients, assuming that the TKI-independent mechanism of action may lead to mutant clone repression...
2016: PloS One
Francesco Raimondi, Javier Rodriguez Fanjul, Salvatore Aversa, Gaetano Chirico, Nadya Yousef, Daniele De Luca, Iuri Corsini, Carlo Dani, Lidia Grappone, Luigi Orfeo, Fiorella Migliaro, Gianfranco Vallone, Letizia Capasso
OBJECTIVES: To evaluate the accuracy of lung ultrasound for the diagnosis of pneumothorax in the sudden decompensating patient. STUDY DESIGN: In an international, prospective study, sudden decompensation was defined as a prolonged significant desaturation (oxygen saturation <65% for more than 40 seconds) and bradycardia or sudden increase of oxygen requirement by at least 50% in less than 10 minutes with a final fraction of inspired oxygen ≥0.7 to keep stable saturations...
August 2016: Journal of Pediatrics
Fátima de Lima Paula, Geraldo Marcelo da Cunha, Iúri da Costa Leite, Rejane Sobrino Pinheiro, Joaquim Gonçalves Valente
OBJECTIVE To identify individual and hospital characteristics associated with the risk of readmission in older inpatients for proximal femoral fracture in the period of 90 days after discharge. METHODS Deaths and readmissions were obtained by a linkage of databases of the Hospital Information System of the Unified Health System and the System of Information on Mortality of the city of Rio de Janeiro from 2008 to 2011. The population of 3,405 individuals aged 60 or older, with non-elective hospitalization for proximal femoral fracture was followed for 90 days after discharge...
2016: Revista de Saúde Pública
Ana Marina Moreira, Thizá M Londero, Iuri M Goemann, Beatriz D Schaan
No abstract text is available yet for this article.
April 19, 2016: Annals of Internal Medicine
Léa Fialkow, Maurício Farenzena, Iuri Christmann Wawrzeniak, Janete Salles Brauner, Sílvia Regina Rios Vieira, Alvaro Vigo, Mary Clarisse Bozzetti
OBJECTIVES: To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD: Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS: A total of 1,115 patients admitted to the ICU needed mechanical ventilation...
March 2016: Clinics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"