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https://www.readbyqxmd.com/read/28717838/the-triterpenoid-alpha-beta-amyrin-prevents-the-impaired-aortic-vascular-reactivity-in-high-fat-diet-induced-obese-mice
#1
Flávia Almeida Santos, Karine Maria Martins Bezerra Carvalho, Francisco José Batista-Lima, Paulo Iury Gomes Nunes, Ana Flávia Seraine Custódio Viana, Armenio André de Carvalho Almeida da Silva, Said Gonçalves da Cruz Fonseca, Mariana Helena Chaves, Vietla Satyanarayana Rao, Pedro Jorge Caldas Magalhães, Teresinha Silva de Brito
To characterize the protective effects of the triterpenoid mixture alpha, beta-amyrin (AMY, 20 mg/kg, during 15 days) on the reactivity of isolated aorta of high-fat diet (HFD)-induced obese mice. Male Swiss mice were fed with HFD or normal diet (ND) for 15 weeks. Contractions of thoracic aorta in response to KCl or phenylephrine (PHE) and relaxation by acetylcholine (ACh) or sodium nitroprusside (SNP) were analyzed. HFD-fed mice developed hyperglycemia, hyperlipidemia, and significant body weight gain, parameters prevented by AMY treatment...
July 17, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28713429/treatment-of-severe-refractory-hematuria-due-to-radiation-induced-hemorrhagic-cystitis-with-dexamethasone
#2
José Carlos Rodrigues Nascimento, Márcio Wilker Soares Campelo, Iuri Arruda Aragão, José Fernando Bastos de Moura, Lúcio Flávio Gonzaga Silva, Reinaldo Barreto Oriá
Treatment of pelvic neoplasms with radiotherapy may develop sequelae, especially RHC. An 85-year-old male patient was admitted to a hospital emergency with gross hematuria leading to urinary retention and was diagnosed with RHC. The urinary bladder was probed, unobstructed, and maintained in continuous three-way saline irrigation. During 45 days of hospitalization, the patient underwent two cystoscopic procedures for urinary bladder flocculation, whole blood transfusions, and one platelet apheresis. None of these interventions led to clinical resolution...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28633418/detecting-and-removing-multiplicative-spatial-bias-in-high-throughput-screening-technologies
#3
Iurie Caraus, Bogdan Mazoure, Robert Nadon, Vladimir Makarenkov
Motivation: Considerable attention has been paid recently to improve data quality in high-throughput screening (HTS) and high-content screening (HCS) technologies widely used in drug development and chemical toxicity research. However, several environmentally- and procedurally-induced spatial biases in these screens decrease measurement accuracy, leading to increased numbers of false positives and false negatives in hit selection. Although effective bias correction methods and software have been developed over the past decades, almost all of these tools have been designed to reduce the effect of additive bias only...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28591150/more-than-one-fungus-in-the-pepper-pot-integrative-taxonomy-unmasks-hidden-species-within-myriostoma-coliforme-geastraceae-basidiomycota
#4
Julieth O Sousa, Laura M Suz, Miguel A García, Donis S Alfredo, Luana M Conrado, Paulo Marinho, A Martyn Ainsworth, Iuri G Baseia, María P Martín
Since the nineteenth century, Myriostoma has been regarded as a monotypic genus with a widespread distribution in north temperate and subtropical regions. However, on the basis of morphological characters and phylogenetic evidence of DNA sequences of the internal transcribed spacer (ITS) regions and the large subunit nuclear ribosomal RNA gene (LSU), four species are now delimited: M. areolatum comb. & stat. nov., M. calongei sp. nov., M. capillisporum comb. & stat. nov., and M. coliforme. Myriostoma coliforme is typified by selecting a lectotype (iconotype) and a modern sequenced collection as an epitype...
2017: PloS One
https://www.readbyqxmd.com/read/28580509/erratum-to-perfusion-index-and-left-ventricular-output-correlation-in-healthy-term-infants
#5
Iuri Corsini, Alessandra Cecchi, Caterina Coviello, Carlo Dani
No abstract text is available yet for this article.
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#6
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28500462/perfusion-index-and-left-ventricular-output-correlation-in-healthy-term-infants
#7
Iuri Corsini, Alessandra Cecchi, Caterina Coviello, Carlo Dani
Perfusion index (PI) is a non-invasive marker of peripheral perfusion which is detected by an oximeter. We aimed to assess the correlation between PI and left ventricular output (LVO) in healthy term infants at the time of the screening for congenital heart disease (CHD). PI was measured at 48±2 h of life in the infant's right hand (PIrh) and in one foot (PIf) contemporary to SpO2 for CHD screening. Heart ultrasound was performed immediately after the screening procedure for measuring LVO. Forty-nine healthy term infants were studied...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28492777/tuberculosis-and-diabetes-probabilistic-linkage-of-databases-to-study-the-association-between-both-diseases
#8
Ricardo Gadelha de Abreu, Artur Iuri Alves de Sousa, Maria Regina Fernandes de Oliveira, Mauro Niskier Sanchez
OBJECTIVE: to describe the profile of cases of tuberculosis and diabetes comorbidity in Brazil. METHODS: this is a descriptive study with data from the Brazilian Information System for Notifiable Diseases - tuberculosis (Sinan-TB) and from the System of Registration and Monitoring of Hypertension and Diabetes Mellitus (Hiperdia), from 2007 to 2011; probabilistic linkage was carried out with Reclink software. RESULTS: 24,443 cases of comorbidity were found, including 3,181 cases not registered on Sinan-TB; of the total number of recovered cases, mostly were males (57...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28454286/suspected-tumor-to-meningioma-metastasis-a-case-report
#9
Iuri Santana Neville, Davi Fontoura Solla, Arthur Maynart Oliveira, Cesar Casarolli, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Tumor-to-meningioma metastasis (TMM) is a fairly uncommon phenomenon. Only 7 cases of prostate cancer with TMM have previously been described in the literature. The present study aimed to report a case of prostate cancer TMM, and to discuss the relevant clinical and neuroimaging aspects of this condition. A 68-year-old patient presented with headaches, poor visual acuity in the left eye and ipsilateral eyelid droop 3 years after a Simpson II resection of a left sphenoid wing meningioma. Computed tomography revealed a hyperdense area suggestive of a recurrent left sphenoid wing meningioma...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28432693/multimodal-neurophysiological-monitoring-in-healthy-infants-born-at-term-normative-continuous-somatosensory-evoked-potentials-data
#10
Silvia Lori, Simonetta Gabbanini, Maria Bastianelli, Giovanna Bertini, Iuri Corsini, Carlo Dani
AIM: To describe accurate, standardized 1h-multimodal neurophysiological monitoring (1h-MNM), while simultaneously recording VEEG, aEEG, and SEP-C bilaterally from median nerves, and to collect neonatal normative SEP-C data related to behavioural states. METHOD: Twenty healthy, term newborn infants (13 males, 7 females; gestational age 37-42wks; mean 39.6wks, standard deviation [SD] 1.3wks) underwent 1h-MNM within 2 days of life, with focus on recording of the SEP-C (band-pass setting 1-100 Hz, rate of stimulation 1...
April 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28418662/partial-in-situ-reduction-of-copper-ii-resulting-in-one-pot-formation-of-2d-neutral-and-3d-cationic-copper-i-iodide-pyrazine-coordination-polymers-structure-and-emissive-properties
#11
Iurie L Malaestean, Victor Ch Kravtsov, Janusz Lipkowski, Elena Cariati, Stefania Righetto, Daniele Marinotto, Alessandra Forni, Marina S Fonari
On the way to copper(I) iodide coordination polymers with specific luminescent properties, the in situ reduction of Cu(II) in the presence of KI and bidentate N-heteroatomic ligand, either pyrazine (pyz) or 4,4'-bipyridine (bpy), resulted in one two-dimensional and two three-dimensional new coordination networks. Starting from Cu(NO3)2·3H2O in the presence of pyz, successive precipitation of known yellow [(Cu(I)I)2(pyz)]n, new orange [Cu(I)I(pyz)]n, and new dark blue {[Cu(I)(pyz)2]·I5}n polymeric solids was observed...
April 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28418232/high-pre-exposure-prophylaxis-uptake-and-early-adherence-among-men-who-have-sex-with-men-and-transgender-women-at-risk-for-hiv-infection-the-prep-brasil-demonstration-project
#12
MULTICENTER STUDY
Brenda Hoagland, Ronaldo I Moreira, Raquel B De Boni, Esper G Kallas, José Valdez Madruga, Ricardo Vasconcelos, Silvia Goulart, Thiago S Torres, Luana M S Marins, Peter L Anderson, Paula M Luz, Iuri da Costa Leite, Albert Y Liu, Valdilea G Veloso, Beatriz Grinsztejn
INTRODUCTION: The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). METHODS: PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System...
April 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28395180/total-cellular-hiv-1-dna-decreases-after-switching-to-raltegravir-based-regimens-in-patients-with-suppressed-hiv-1-rna
#13
Barbara Rossetti, Genny Meini, Claudia Bianco, Silvia Lamonica, Annalisa Mondi, Simone Belmonti, Iuri Fanti, Nicoletta Ciccarelli, Simona Di Giambenedetto, Maurizio Zazzi, Andrea De Luca
BACKGROUND: The integrase inhibitor raltegravir has been used to intensify antiretroviral therapy in patients with undetectable plasma HIV-1RNA, resulting in variable perturbation of HIV-1 nucleic acids levels in peripheral blood. OBJECTIVES: We aimed at monitoring residual plasma HIV-1RNA and total cellular HIV-1DNA in virologically suppressed patients switching to raltegravir-based regimens. STUDY DESIGN: Fifty-eight subjects on protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens, with plasma HIV-1RNA levels <40 copies/ml for ≥6 months and CD4 counts >200cells/μl for ≥12 months were enrolled...
March 23, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28367357/resuscitation-with-intact-placental-circulation-in-a-preterm-infant-with-hydrops-fetalis
#14
Simone Pratesi, Iuri Corsini, Caterina Coviello, Silvia Perugi, Carlo Dani
A preterm infant with prenatal diagnosis of hydrops fetalis was spontaneously delivered at 30 weeks of gestational age in a tertiary level hospital. Prenatal echography pointed out severe bilateral pleural effusions and diffused subcutaneous edema. A neonatologist team, alerted at the expulsion stage of labor, assisted the neonate immediately after birth and bilateral hydrothorax was drained with intact placental circulation to avoid a nonrespiratory period and its possible detrimental hemodynamic effects. The newborn was well stabilized in the delivery room before cutting the umbilical cord and starting mechanical ventilation...
January 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28273092/the-100th-an-appealing-new-species-of-dendropsophus-amphibia-anura-hylidae-from-northeastern-brazil
#15
Iuri Ribeiro Dias, Célio Fernando Baptista Haddad, Antônio Jorge Suzart Argôlo, Victor Goyannes Dill Orrico
We describe a new species of the Dendropsophus leucophyllatus Group from the Atlantic Forest of the southern region of State of Bahia, Brazil. It can be distinguished from all species of the D. leucophyllatus Group on the basis of morphological characters (especially its unique dorsal pattern and snout in dorsal view), advertisement calls and divergence in mitochondrial DNA gene sequences. The inclusion of D. anceps on the group remains controversial but our phylogenetic analyses do not recover the new species as sister to syntopic species of the D...
2017: PloS One
https://www.readbyqxmd.com/read/28225872/sensorineural-hearing-loss-as-the-first-manifestation-of-sj%C3%A3-gren-s-syndrome
#16
Raquel Sousa Almeida, Ana Alves Oliveira, Petra M Pego, Yahia Abuowda, Iuri Gaspar, João Matos Costa
No abstract text is available yet for this article.
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28002414/discovery-or-extinction-of-new-scleroderma-species-in-amazonia
#17
Iuri G Baseia, Bianca D B Silva, Noemia K Ishikawa, João V C Soares, Isadora F França, Shuji Ushijima, Nitaro Maekawa, María P Martín
The Amazon Forest is a hotspot of biodiversity harboring an unknown number of undescribed taxa. Inventory studies are urgent, mainly in the areas most endangered by human activities such as extensive dam construction, where species could be in risk of extinction before being described and named. In 2015, intensive studies performed in a few locations in the Brazilian Amazon rainforest revealed three new species of the genus Scleroderma: S. anomalosporum, S. camassuense and S. duckei. The two first species were located in one of the many areas flooded by construction of hydroelectric dams throughout the Amazon; and the third in the Reserva Florestal Adolpho Ducke, a protected reverse by the INPA...
2016: PloS One
https://www.readbyqxmd.com/read/27997576/reconciling-mining-with-the-conservation-of-cave-biodiversity-a-quantitative-baseline-to-help-establish-conservation-priorities
#18
Rodolfo Jaffé, Xavier Prous, Robson Zampaulo, Tereza C Giannini, Vera L Imperatriz-Fonseca, Clóvis Maurity, Guilherme Oliveira, Iuri V Brandi, José O Siqueira
Caves pose significant challenges for mining projects, since they harbor many endemic and threatened species, and must therefore be protected. Recent discussions between academia, environmental protection agencies, and industry partners, have highlighted problems with the current Brazilian legislation for the protection of caves. While the licensing process is long, complex and cumbersome, the criteria used to assign caves into conservation relevance categories are often subjective, with relevance being mainly determined by the presence of obligate cave dwellers (troglobites) and their presumed rarity...
2016: PloS One
https://www.readbyqxmd.com/read/27979110/sweetness-prediction-of-natural-compounds
#19
Jean-Baptiste Chéron, Iuri Casciuc, Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci
Based on the most exhaustive database of sweeteners with known sweetness values, a new quantitative structure-activity relationship model for sweetness prediction has been set up. Analysis of the physico-chemical properties of sweeteners in the database indicates that the structure of most potent sweeteners combines a hydrophobic scaffold functionalized by a limited number of hydrogen bond sites (less than 4 hydrogen bond donors and 10 acceptors), with a moderate molecular weight ranging from 350 to 450g·mol(-1)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973471/peroxisome-proliferator-activated-receptor-%C3%AE-agonist-pioglitazone-reduces-the-development-of-necrotizing-enterocolitis-in-a-neonatal-preterm-rat-model
#20
Iuri Corsini, Simone Polvani, Mirko Tarocchi, Sara Tempesti, Giada Marroncini, Marta Generoso, Cecilia Bresci, Elena Gozzini, Tommaso Bianconi, Andrea Galli, Carlo Dani
BACKGROUND: Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity. METHODS: We studied preterm rats in which NEC was induced using the hypoxia-hypothermia model...
December 14, 2016: Pediatric Research
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