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https://www.readbyqxmd.com/read/28432693/multimodal-neurophysiological-monitoring-in-healthy-infants-born-at-term-normative-continuous-somatosensory-evoked-potentials-data
#1
Silvia Lori, Simonetta Gabbanini, Maria Bastianelli, Giovanna Bertini, Iuri Corsini, Carlo Dani
AIM: To describe accurate, standardized 1h-multimodal neurophysiological monitoring (1h-MNM), while simultaneously recording VEEG, aEEG, and SEP-C bilaterally from median nerves, and to collect neonatal normative SEP-C data related to behavioural states. METHOD: Twenty healthy, term newborn infants (13 males, 7 females; gestational age 37-42wks; mean 39.6wks, standard deviation [SD] 1.3wks) underwent 1h-MNM within 2 days of life, with focus on recording of the SEP-C (band-pass setting 1-100 Hz, rate of stimulation 1...
April 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28418662/partial-in-situ-reduction-of-copper-ii-resulting-in-one-pot-formation-of-2d-neutral-and-3d-cationic-copper-i-iodide-pyrazine-coordination-polymers-structure-and-emissive-properties
#2
Iurie L Malaestean, Victor Ch Kravtsov, Janusz Lipkowski, Elena Cariati, Stefania Righetto, Daniele Marinotto, Alessandra Forni, Marina S Fonari
On the way to copper(I) iodide coordination polymers with specific luminescent properties, the in situ reduction of Cu(II) in the presence of KI and bidentate N-heteroatomic ligand, either pyrazine (pyz) or 4,4'-bipyridine (bpy), resulted in one two-dimensional and two three-dimensional new coordination networks. Starting from Cu(NO3)2·3H2O in the presence of pyz, successive precipitation of known yellow [(Cu(I)I)2(pyz)]n, new orange [Cu(I)I(pyz)]n, and new dark blue {[Cu(I)(pyz)2]·I5}n polymeric solids was observed...
April 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28418232/high-pre-exposure-prophylaxis-uptake-and-early-adherence-among-men-who-have-sex-with-men-and-transgender-women-at-risk-for-hiv-infection-the-prep-brasil-demonstration-project
#3
Brenda Hoagland, Ronaldo I Moreira, Raquel B De Boni, Esper G Kallas, José Valdez Madruga, Ricardo Vasconcelos, Silvia Goulart, Thiago S Torres, Luana M S Marins, Peter L Anderson, Paula M Luz, Iuri da Costa Leite, Albert Y Liu, Valdilea G Veloso, Beatriz Grinsztejn
INTRODUCTION: The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). METHODS: PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System...
April 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28395180/total-cellular-hiv-1-dna-decreases-after-switching-to-raltegravir-based-regimens-in-patients-with-suppressed-hiv-1-rna
#4
Barbara Rossetti, Genny Meini, Claudia Bianco, Silvia Lamonica, Annalisa Mondi, Simone Belmonti, Iuri Fanti, Nicoletta Ciccarelli, Simona Di Giambenedetto, Maurizio Zazzi, Andrea De Luca
BACKGROUND: The integrase inhibitor raltegravir has been used to intensify antiretroviral therapy in patients with undetectable plasma HIV-1RNA, resulting in variable perturbation of HIV-1 nucleic acids levels in peripheral blood. OBJECTIVES: We aimed at monitoring residual plasma HIV-1RNA and total cellular HIV-1DNA in virologically suppressed patients switching to raltegravir-based regimens. STUDY DESIGN: Fifty-eight subjects on protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens, with plasma HIV-1RNA levels <40 copies/ml for ≥6 months and CD4 counts >200cells/μl for ≥12 months were enrolled...
March 23, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28367357/resuscitation-with-intact-placental-circulation-in-a-preterm-infant-with-hydrops-fetalis
#5
Simone Pratesi, Iuri Corsini, Caterina Coviello, Silvia Perugi, Carlo Dani
A preterm infant with prenatal diagnosis of hydrops fetalis was spontaneously delivered at 30 weeks of gestational age in a tertiary level hospital. Prenatal echography pointed out severe bilateral pleural effusions and diffused subcutaneous edema. A neonatologist team, alerted at the expulsion stage of labor, assisted the neonate immediately after birth and bilateral hydrothorax was drained with intact placental circulation to avoid a nonrespiratory period and its possible detrimental hemodynamic effects. The newborn was well stabilized in the delivery room before cutting the umbilical cord and starting mechanical ventilation...
January 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28273092/the-100th-an-appealing-new-species-of-dendropsophus-amphibia-anura-hylidae-from-northeastern-brazil
#6
Iuri Ribeiro Dias, Célio Fernando Baptista Haddad, Antônio Jorge Suzart Argôlo, Victor Goyannes Dill Orrico
We describe a new species of the Dendropsophus leucophyllatus Group from the Atlantic Forest of the southern region of State of Bahia, Brazil. It can be distinguished from all species of the D. leucophyllatus Group on the basis of morphological characters (especially its unique dorsal pattern and snout in dorsal view), advertisement calls and divergence in mitochondrial DNA gene sequences. The inclusion of D. anceps on the group remains controversial but our phylogenetic analyses do not recover the new species as sister to syntopic species of the D...
2017: PloS One
https://www.readbyqxmd.com/read/28225872/sensorineural-hearing-loss-as-the-first-manifestation-of-sj%C3%A3-gren-s-syndrome
#7
Raquel Sousa Almeida, Ana Alves Oliveira, Petra M Pego, Yahia Abuowda, Iuri Gaspar, João Matos Costa
No abstract text is available yet for this article.
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28002414/discovery-or-extinction-of-new-scleroderma-species-in-amazonia
#8
Iuri G Baseia, Bianca D B Silva, Noemia K Ishikawa, João V C Soares, Isadora F França, Shuji Ushijima, Nitaro Maekawa, María P Martín
The Amazon Forest is a hotspot of biodiversity harboring an unknown number of undescribed taxa. Inventory studies are urgent, mainly in the areas most endangered by human activities such as extensive dam construction, where species could be in risk of extinction before being described and named. In 2015, intensive studies performed in a few locations in the Brazilian Amazon rainforest revealed three new species of the genus Scleroderma: S. anomalosporum, S. camassuense and S. duckei. The two first species were located in one of the many areas flooded by construction of hydroelectric dams throughout the Amazon; and the third in the Reserva Florestal Adolpho Ducke, a protected reverse by the INPA...
2016: PloS One
https://www.readbyqxmd.com/read/27997576/reconciling-mining-with-the-conservation-of-cave-biodiversity-a-quantitative-baseline-to-help-establish-conservation-priorities
#9
Rodolfo Jaffé, Xavier Prous, Robson Zampaulo, Tereza C Giannini, Vera L Imperatriz-Fonseca, Clóvis Maurity, Guilherme Oliveira, Iuri V Brandi, José O Siqueira
Caves pose significant challenges for mining projects, since they harbor many endemic and threatened species, and must therefore be protected. Recent discussions between academia, environmental protection agencies, and industry partners, have highlighted problems with the current Brazilian legislation for the protection of caves. While the licensing process is long, complex and cumbersome, the criteria used to assign caves into conservation relevance categories are often subjective, with relevance being mainly determined by the presence of obligate cave dwellers (troglobites) and their presumed rarity...
2016: PloS One
https://www.readbyqxmd.com/read/27979110/sweetness-prediction-of-natural-compounds
#10
Jean-Baptiste Chéron, Iuri Casciuc, Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci
Based on the most exhaustive database of sweeteners with known sweetness values, a new quantitative structure-activity relationship model for sweetness prediction has been set up. Analysis of the physico-chemical properties of sweeteners in the database indicates that the structure of most potent sweeteners combines a hydrophobic scaffold functionalized by a limited number of hydrogen bond sites (less than 4 hydrogen bond donors and 10 acceptors), with a moderate molecular weight ranging from 350 to 450g·mol(-1)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973471/peroxisome-proliferator-activated-receptor-%C3%AE-agonist-pioglitazone-reduces-the-development-of-necrotizing-enterocolitis-in-a-neonatal-preterm-rat-model
#11
Iuri Corsini, Simone Polvani, Mirko Tarocchi, Sara Tempesti, Giada Marroncini, Marta Generoso, Cecilia Bresci, Elena Gozzini, Tommaso Bianconi, Andrea Galli, Carlo Dani
BACKGROUND: Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity. METHODS: We studied preterm rats in which NEC was induced using the hypoxia-hypothermia model...
December 14, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27869918/spatial-and-temporal-analysis-of-aids-cases-in-brazil-1996-2011-increased-risk-areas-over-time
#12
Artur Iuri Alves de Sousa, Vitor Laerte Pinto
OBJECTIVE: to identify areas with greater risk of AIDS transmission in Brazil. METHODS: this is an ecological study involving georeference of AIDS cases incidence, prevalence and density in Brazilian municipalities using the Kernel method for the periods 1996-1999, 2000-2003, 2004-2007 and 2008-2011. RESULTS: 633,512 AIDS cases were reported between 1996-2011; between 2008-2011, there was increased risk of AIDS transmission in Recife-João Pessoa region, the emergence of areas with average density in the regions of Belém, São Luís, Maceió, Aracaju and Salvador, and a decline in the intensity of risk in São Paulo, Campinas and Ribeirão Preto; prevalence rates were most concentrated in the Southeast, South and Midwest regions of the country...
July 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27863758/determination-of-reference-ranges-for-immature-platelet-and-reticulocyte-fractions-and-reticulocyte-hemoglobin-equivalent
#13
Iuri Vicente Camargo Morkis, Mariela Granero Farias, Luciana Scotti
INTRODUCTION: The immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content. They are considered early indicators of bone marrow recovery. OBJECTIVE: The aim of this study was to determine the reference ranges for the immature platelet and reticulocyte fractions of hematologically normal individuals in a university hospital. METHODS: Venous blood samples collected in ethylenediaminetetraacetic acid K3 were analyzed using a Sysmex XE-5000™ analyzer...
October 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27858869/switch-of-predicted-hiv-1-tropism-in-treated-subjects-and-its-association-with-disease-progression
#14
Antonella Castagna, Laura Monno, Stefania Carta, Laura Galli, Stefania Carrara, Valentina Fedele, Grazia Punzi, Iuri Fanti, Pietro Caramello, Alessandro Cozzi Lepri, Andrea De Luca, Francesca Ceccherini-Silberstein, Antonella d'Arminio Monforte
Dynamics of human immunodeficiency virus type 1 (HIV-1) tropism after antiretroviral therapy (ART) initiation and their association with disease progression are poorly investigated.This was a cohort study on subjects from the ICONA cohort receiving ART with persistently detectable (PD) or persistently undetectable (PU) viral load (VL) and with stored plasma or peripheral blood mononuclear cell (PBMC) samples at 2 time-points (T1, T2) after ART initiation. HIV-1 co-receptor tropism was determined by V3-loop sequencing and the geno2pheno algorithm...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855525/the-biochemical-characterization-stabilization-studies-and-the-antiproliferative-effect-of-bromelain-against-b16f10-murine-melanoma-cells
#15
Íngara Keisle São Paulo Barretto Miranda, Anderson Fontes Suzart Miranda, Fernanda Vidigal Duarte Souza, Marcos André Vannier-Santos, Carlos Priminho Pirovani, Iuri Muniz Pepe, Ivanoé João Rodowanski, Katiúcia Tícila de Souza Eduvirgens Ferreira, Luciano Mendes Souza Vaz, Sandra Aparecida de Assis
The current study aims to extract bromelain from different parts (stem, crown, peels, pulp and leaves) of Ananas comosus var. comosus AGB 772; to determine of optimum pH and temperature; to test bromelain stability in disodium EDTA and sodium benzoate, and to investigate its pharmacological activity on B16F10 murine melanoma cells in vitro. The highest enzymatic activity was found in bromelain extracted from the pulp and peel. The optimum bromelain pH among all studied pineapple parts was 6.0. The optimum temperature was above 50 °C in all bromelain extracts...
June 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27849272/community-viral-load-of-hiv-in-brazil-2007-2011-potential-impact-of-highly-active-antiretroviral-therapy-haart-in-reducing-new-infections
#16
Artur Iuri Alves de Sousa, Vitor Laerte Pinto
Objectives: To estimate the human immunodeficiency virus (HIV) viral load in the Brazilian population and to assess the potential impact of highly active antiretroviral therapy (HAART) in reducing new infections to build evidences and to gather information to support health policies. Methods: Spatial analysis and modeling tools were used to describe the existing patterns of the viral load density, using the Kernel method. Data on viral load and treatment were retrieved from the databases Laboratory Tests Control System (SISCEL), which contains information on the individual's history of viral load, and Medication Logistics Control System (SICLOM), which controls the dispensing of drugs used for antiretroviral therapy...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27849271/quality-of-hospital-databases-in-brazil-some-elements
#17
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
Introduction: The use of secondary data for health service research has been increasingly common, having the advantage of acquiring information faster and cheaper, in addition to its larger population, temporal and geographical amplitude. Objectives: The aim of this study was to describe problems in the quality of information about hospitals characteristics and hospitalizations in Brazil. Methods: The National Database on Health Units (CNES), the Public Hospital Information System (SIH), and the Private Hospital Information System (CIH) were analyzed...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27832129/temporal-and-spatial-evolution-of-dengue-incidence-in-brazil-2001-2012
#18
Nádia Cristina Pinheiro Rodrigues, Valéria Teresa Saraiva Lino, Regina Paiva Daumas, Mônica Kramer de Noronha Andrade, Gisele O'Dwyer, Denise Leite Maia Monteiro, Alyssa Gerardi, Gabriel Henrique Barroso Viana Fernandes, José Augusto Sapienza Ramos, Carlos Eduardo Gonçalves Ferreira, Iuri da Costa Leite
BACKGROUND: In Brazil, the incidence of dengue greatly increased in the last two decades and there are several factors impeding the control of the disease. The present study focused on describing the space-time evolution of dengue in Brazil from 2001 to 2012 and analyzing the relationship of the reported cases with socio-demographic and environmental factors. METHODS: The analytic units used in the preparation of thematic maps were municipalities. Statistical tests and multilevel regression models were used to evaluate the association between dengue incidence and the following factors: climate, diagnostic period, demographic density, percentage of people living in rural areas, Gross Domestic Product, Gini index, percentage of garbage collection and the rate of households with a sewage network...
2016: PloS One
https://www.readbyqxmd.com/read/27830534/guanosine-protects-against-traumatic-brain-injury-induced-functional-impairments-and-neuronal-loss-by-modulating-excitotoxicity-mitochondrial-dysfunction-and-inflammation
#19
Rogério da Rosa Gerbatin, Gustavo Cassol, Fernando Dobrachinski, Ana Paula O Ferreira, Caroline B Quines, Iuri D Della Pace, Guilherme L Busanello, Jessié M Gutierres, Cristina W Nogueira, Mauro S Oliveira, Félix A Soares, Vera M Morsch, Michele R Fighera, Luiz Fernando F Royes
Traumatic brain injury (TBI) is one of the most common types of brain injuries that cause death or persistent neurological disturbances in survivors. Most of the promising experimental drugs were not effective in clinical trials; therefore, the development of TBI drugs represents a huge unmet need. Guanosine, an endogenous neuroprotective nucleoside, has not been evaluated in TBI to the best of our knowledge. Therefore, the present study evaluated the effect of guanosine on TBI-induced neurological damage. Our findings showed that a single dose of guanosine (7...
November 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27826184/design-development-and-characterization-of-lipid-nanocarriers-based-epigallocatechin-gallate-delivery-system-for-preventive-and-therapeutic-supplementation
#20
Iúri Frias, Ana Rute Neves, Marina Pinheiro, Salette Reis
Green tea is manufactured from the leaves of Camellia sinensis and has been shown to possess, among other properties, anticancer, antiobesity, antiatherosclerotic, antidiabetic, antibacterial, and antiviral effects. The beneficial effects of green tea are related to the activities of (-)-epigallocatechin gallate (EGCG). This catechin is very unstable, undergoing degradation and epimerization, which is responsible for the loss of its health benefits. Encapsulation in nanoparticles (NPs) is an effective method to protect EGCG from adverse environmental conditions...
2016: Drug Design, Development and Therapy
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