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https://www.readbyqxmd.com/read/29210409/narcissistic-chiral-self-sorting-of-molecular-face-rotating-polyhedra
#1
Xinchang Wang, Pixian Peng, Wei Xuan, Yu Wang, Yongbin Zhuang, Zhongqun Tian, Xiaoyu Cao
Narcissistic chiral self-sorting prevailed in the assembly of molecular face-rotating polyhedra from a C3h building block 5,5,10,10,15,15-hexabutyl-truxene-2,7,12-tricarbaldehyde and racemic mixtures of 1,2-diamines. Out of 124 possible stereoisomers, a pair of racemic polyhedra dominated, wherein (1R,2R)-diamines were segregated in AAAA polyhedra and (1S,2S)-diamines in CCCC polyhedra. This chiral self-sorting process is regulated by facial non-covalent interactions in the polyhedra. In contrast, D3h facial building blocks 1,3,5-tris-(4-formyl-phenyl)triazine and racemic mixtures of 1,2-diamines assembled into polyhedra without facial interactions, and their assembly process did not undergo apparent chiral self-sorting...
December 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29189974/association-of-sirt1-gene-polymorphism-and-its-expression-for-the-risk-of-alcoholic-fatty-liver-disease-in-the-han-population
#2
Yeting Hou, Bingzhong Su, Ping Chen, Haijing Niu, Sheng Zhao, Ruijun Wang, Wei Shen
OBJECTIVE: To investigate the associations between SIRT1 polymorphisms and their expression in patients with alcoholic fatty liver disease (AFLD). METHODS: A total of 268 heavy drinkers were divided into the AFLD group (n = 176) and alcoholic control (n = 92) and 237 light-/non-drinkers into the NAFLD (non-AFLD) group (n = 117) and healthy control (n = 120). The genotyping of SIRT1 (rs33957861, rs11599176, rs12413112 and rs35689145) was detected by the Sequenom MassARRAY iPLEX test...
November 30, 2017: Hepatology International
https://www.readbyqxmd.com/read/29046239/increased-peak-wall-stress-but-not-maximum-diameter-is-associated-with-symptomatic-abdominal-aortic-aneurysm
#3
Begoña Soto, Luis Vila, Jaime F Dilmé, Jose R Escudero, Sergi Bellmunt, Mercedes Camacho
OBJECTIVE: Maximum diameter (MD) is the established rupture predictor for abdominal aortic aneurysm (AAA). However, biomechanical markers from finite element analysis (FEA) could be more accurate predictors for these patients. In this study, the association between peak wall stress (PWS) and MD with symptoms of AAA was evaluated. METHODS: Patients diagnosed with infrarenal non-ruptured AAA at the centre between 2009 and 2015 were included. Clinical data, morphological variables (including MD), and the biomechanical variables PWS and diameter normalised PWS (dnPWS) in symptomatic (sAAA) and asymptomatic AAA patients (aAAA) were included...
October 15, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28795444/prediction-of-shorter-oligonucleotide-sequences-recognizing-aflatoxin-m1
#4
Amit Kumar Pandey, Yudhishthir Singh Rajput, Dheer Singh, Rajan Sharma
Aflatoxin M1 (AFM1) is present in milk of lactating animals fed on aflatoxin B1 contaminated feeds. Aptamers are new emerging ligand molecules and can be employed in assay protocols. Shorter aptamers have several advantages. Untruncated (72-nucleotide long) and truncated (18- to 42-nucleotide long) aptamers were evaluated for AFM1 recognition that was detected by color change in aptamer-conjugated gold nanoparticles in the presence of AFM1. Truncation of 10 aptamers was designed to retain motifs. Untruncated and truncated aptamers recognized AFM1...
August 10, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28754346/characterization-of-two-peptides-isolated-from-the-venom-of-social-wasp-chartergellus-communis-hymenoptera-vespidae-influence-of-multiple-alanine-residues-and-c-terminal-amidation-on-biological-effects
#5
Kamila Soares Lopes, Gabriel Avohay Alves Campos, Luana Cristina Camargo, Adolfo Carlos Barros de Souza, Beatriz Vasconcelos Ibituruna, Ana Carolina Martins Magalhães, Lucas Ferreira da Rocha, Alessa Bembom Garcia, Mosar Correa Rodrigues, Dagon Manoel Ribeiro, Michelle Cruz Costa, Manuel Humberto Mera López, Luciana Marangni Nolli, Fernando Zamudio-Zuniga, Lourival Domingos Possani, Elisabeth Ferroni Schwartz, Márcia Renata Mortari
Chatergellus communis is a wasp species endemic to the neotropical region and its venom constituents have never been described. In this study, two peptides from C. communis venom, denominated Communis and Communis-AAAA, were chemically and biologically characterized. In respect to the chemical characterization, the following amino acid sequences and molecular masses were identified: Communis: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-COOH (1340.9Da) Communis-AAAA: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-Ala-Ala-Ala-Ala-Val-Xle-NH2 (1836...
July 25, 2017: Peptides
https://www.readbyqxmd.com/read/28671230/synthesis-and-characterization-of-two-layered-aluminophosphates-r-c8h12n-8-h2o-2%C3%A2-al8p12o48h4-and-s-c8h12n-8-h2o-2%C3%A2-al8p12o48h4-with-a-mirror-symmetric-feature-and-their-proton-conductivity
#6
Yue Yu, Jingran Zhu, Jiancong Liu, Yan Yan, Xiaowei Song
The template effect of chiral organic molecules to aluminophosphate open frameworks was investigated by the syntheses of two layered structures, [R-C8H12N]8[H2O]2·[Al8P12O48H4] and [S-C8H12N]8[H2O]2·[Al8P12O48H4] (denoted as AlPO-CJ72-R and -S), with a mirror symmetric feature. The two structures are obtained separately, which is the first instance in inorganic open-framework materials to our knowledge, by α-methylbenzylamine with homochirality. Single-crystal X-ray diffraction analysis reveals that the structure of either AlPO-CJ72-R or AlPO-CJ72-S crystallizes in the chiral triclinic space group P1, and the existence of AAAA-stacked Al2P3O12(3-) layers made up of alternating AlO4 and PO3([double bond, length as m-dash]O) or PO2([double bond, length as m-dash]O)(OH) tetrahedra to form a 4 × 6 network...
July 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28451167/homochiral-oligomers-with-highly-flexible-backbones-form-stable-h-bonded-duplexes
#7
Diego Núñez-Villanueva, Christopher A Hunter
Two homochiral building blocks featuring a protected thiol, an alkene and a H-bond recognition unit (phenol or phosphine oxide) have been prepared. Iterative photochemical thiol-ene coupling reactions were used to synthesize oligomers containing 1-4 phosphine oxide and 1-4 phenol recognition sites. Length-complementary H-bond donor and H-bond acceptor oligomers were found to form stable duplexes in toluene. NMR titrations and thermal denaturation experiments show that the association constant and the enthalpy of duplex formation increase significantly for every additional H-bonding unit added to the chain...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28434701/upregulated-interleukins-il-6-il-10-and-il-13-in-immunoglobulin-g4-related-aortic-aneurysm-patients
#8
Satomi Kasashima, Atsuhiro Kawashima, Yoh Zen, Satoru Ozaki, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
OBJECTIVE: Immunoglobulin (Ig) G4-related aortic aneurysms (IgG4-AAs) are a special aortic aneurysm among IgG4-related diseases (IgG4-RDs), which are inflammatory and fibrous conditions characterized by tumorous swelling of affected organs and high serum IgG4 concentrations. Recently, IgG4-RD pathogenesis was shown to be associated with T-helper-2 (Th2) and regulatory T (Treg) dominant cytokine production, such as interleukin (IL)-4, IL-10, and IL-13. IL-6 is a key proinflammatory cytokine contributing to lymphocyte and plasmacyte maturation and to atherosclerosis and aneurysm development...
April 20, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28360498/arthroscopic-assisted-ankle-arthrodesis-a-retrospective-study-of-32-cases
#9
Raju Vaishya, Ahmad Tariq Azizi, Amit Kumar Agarwal, Vipul Vijay
PURPOSE: The arthroscopic assisted ankle arthrodesis (AAAA) is a minimally invasive procedure for end-stage ankle arthritis with numerous benefits like faster time of union, insignificant blood loss, less morbidity, less infection rate, and less soft tissue complications. A shorter hospital stay decreases the cost and results in early mobilization compared to open methods. We present a retrospective series of 32 patients, who underwent AAAA during a period of 8 years. METHODS: Thirty-two patients were reviewed retrospectively from 2008 to 2015...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28256396/adjusted-hospital-outcomes-of-abdominal-aortic-aneurysm-surgery-reported-in-the-dutch-surgical-aneurysm-audit
#10
N Lijftogt, A C Vahl, E D Wilschut, B H P Elsman, S Amodio, E W van Zwet, V J Leijdekkers, M W J M Wouters, J F Hamming
OBJECTIVE/BACKGROUND: The Dutch Surgical Aneurysm Audit (DSAA) is mandatory for all patients with primary abdominal aortic aneurysms (AAAs) in the Netherlands. The aims are to present the observed outcomes of AAA surgery against the predicted outcomes by means of V-POSSUM (Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity). Adjusted mortality was calculated by the original and re-estimated V(physiology)-POSSUM for hospital comparisons. METHODS: All patients operated on from January 2013 to December 2014 were included for analysis...
April 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28043867/bont-ab-hybrid-maintains-similar-duration-of-paresis-as-bont-a-wild-type-in-murine-running-wheel-assay
#11
Anna Kutschenko, Marie-Christine Reinert, Nadja Krez, David Liebetanz, Andreas Rummel
The highly potent Botulinum neurotoxins (BoNT) are successful drugs to treat neuromuscular disorders. Efforts are being made to further reduce the injected BoNT dose and to lengthen the interval between treatments. Detailed knowledge of the BoNT structure-activity relationship (SAR) allows combining the best features of the different BoNT serotypes. Of all seven BoNT serotypes A-G, BoNT/A displays the highest potency despite low neuronal binding affinity, while BoNT/B exhibits much higher affinity. Recently, a new BoNT/AB hybrid (AABB) was constructed comprising the catalytic and translocation domain of BoNT/A and the 50kDa cell binding domain of BoNT/B...
December 30, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/28033005/predicting-rna-structures-via-a-simple-van-der-waals-correction-to-an-all-atom-force-field
#12
Changwon Yang, Manho Lim, Eunae Kim, Youngshang Pak
We proposed a simple van der Waals backbone correction (O2' and OP) to the AMBER ff12 force field in conjunction with the OPC water via an unequal Lorentz-Berthelot combination rule. As tested on four different tetranuceotides such as r(GACC), r(CCCC), r(AAAA), and r(CAAU), this new force field correctly captured each native fold as the largest population. For a RNA tetraloop (UUCG) tested, the stability of its native fold is substantially improved.
January 3, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/27819682/ripk1-inhibits-zbp1-driven-necroptosis-during-development
#13
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Andreas Strasser, Victoria C Pham, Jennie R Lill, Merone Roose-Girma, Søren Warming, Margaret Solon, Hai Ngu, Joshua D Webster, Vishva M Dixit
Receptor-interacting protein kinase 1 (RIPK1) promotes cell survival-mice lacking RIPK1 die perinatally, exhibiting aberrant caspase-8-dependent apoptosis and mixed lineage kinase-like (MLKL)-dependent necroptosis. However, mice expressing catalytically inactive RIPK1 are viable, and an ill-defined pro-survival function for the RIPK1 scaffold has therefore been proposed. Here we show that the RIP homotypic interaction motif (RHIM) in RIPK1 prevents the RHIM-containing adaptor protein ZBP1 (Z-DNA binding protein 1; also known as DAI or DLM1) from activating RIPK3 upstream of MLKL...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27790182/neuroelectric-and-behavioral-effects-of-acute-exercise-on-task-switching-in-children-with-attention-deficit-hyperactivity-disorder
#14
Chiao-Ling Hung, Chung-Ju Huang, Yu-Jung Tsai, Yu-Kai Chang, Tsung-Min Hung
The main purpose of this two-part study was to examine the effects of acute, moderate intensity exercise on task switching in children with attention-deficit/hyperactivity disorder (ADHD). In Study 1, we compared the task switching performance of children with and without ADHD. Twenty children with ADHD and 20 matched controls performed the task switching paradigm, in which the behavioral indices and P3 component of event-related potentials elicited by task-switching were assessed simultaneously. The amplitude and latency of P3 reflected the amount of attention resource allocated to task-relevant stimulus in the environment and the efficiency of stimulus detection and evaluation, respectively...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27671350/apelin-binding-to-human-apj-receptor-leads-to-biased-signaling
#15
Prashant Kumar, Anisha Ashokan, Gopala Krishna Aradhyam
BACKGROUND: Human APJ receptor (APJR), a rhodopsin family G-Protein Coupled Receptor (GPCR), activated by isoforms of peptide ligand apelin causing potent inotropic effect, is involved in cardiac function, angiogenesis and maintenance of fluid homeostasis. APJR is expressed in various organs e.g., heart, brain, kidney, muscles, etc. Hence, problems in APJR signaling lead to severe dysregulation in the pathophysiology of an organism. METHODS: Based on multiple sequence alignment of receptors from various organisms, we observe a large number of conserved residues in the extracellular side...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27559481/protein-quantification-by-derivatization-free-high-performance-liquid-chromatography-of-aromatic-amino-acids
#16
Almut Hesse, Michael G Weller
Amino acid analysis is considered to be the gold standard for quantitative peptide and protein analysis. Here, we would like to propose a simple HPLC/UV method based on a reversed-phase separation of the aromatic amino acids tyrosine (Tyr), phenylalanine (Phe), and optionally tryptophan (Trp) without any derivatization. The hydrolysis of the proteins and peptides was performed by an accelerated microwave technique, which needs only 30 minutes. Two internal standard compounds, homotyrosine (HTyr) and 4-fluorophenylalanine (FPhe) were used for calibration...
2016: Journal of Amino Acids
https://www.readbyqxmd.com/read/27378885/oscillation-phase-locking-and-late-erp-components-of-intracranial-hippocampal-recordings-correlate-to-patient-performance-in-a-working-memory-task
#17
Jonathan K Kleen, Markus E Testorf, David W Roberts, Rod C Scott, Barbara J Jobst, Gregory L Holmes, Pierre-Pascal Lenck-Santini
In working memory tasks, stimulus presentation induces a resetting of intracranial temporal lobe oscillations in multiple frequency bands. To further understand the functional relevance of this phenomenon, we investigated whether working memory performance depends on the phase precision of ongoing oscillations in the hippocampus. We recorded intra-hippocampal local field potentials in individuals performing a working memory task. Two types of trials were administered. For high memory trials presentation of a list of four letters ("List") was followed by a single letter memory probe ("Test")...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27357306/pitfalls-in-the-synthesis-of-fluorescent-methotrexate-oligopeptide-conjugates
#18
Mónika Sebestyén, György Kóczán, Ferenc Hudecz
Methotrexate (MTX) conjugates with poly[Lys(DL-Alam)] based polymeric polypeptides are efficient against Leishmania donovani parasite infection, but the mechanism of the effect is not known yet. We prepared therefore the 5(6)-carboxyfluorescein (Cf) labeled oligopeptide [Cf-K(AaAa)] (a: D-alanine, A: L-alanine) and the corresponding MTX conjugates [Cf-K(MTX-AaAa)] as model compounds for structure-activity experiments. The conjugate aimed to be synthesized with solid phase methodology on MBHA resin with Boc strategy, using Fmoc-Lys(Boc)-OH...
November 2016: Amino Acids
https://www.readbyqxmd.com/read/27013233/distinct-roles-of-autophagy-dependent-and-independent-functions-of-fip200-revealed-by-generation-and-analysis-of-a-mutant-knock-in-mouse-model
#19
Song Chen, Chenran Wang, Syn Yeo, Chun-Chi Liang, Takako Okamoto, Shaogang Sun, Jian Wen, Jun-Lin Guan
Autophagy is an evolutionarily conserved cellular process controlled through a set of essential autophagy genes (Atgs). However, there is increasing evidence that most, if not all, Atgs also possess functions independent of their requirement in canonical autophagy, making it difficult to distinguish the contributions of autophagy-dependent or -independent functions of a particular Atg to various biological processes. To distinguish these functions for FIP200 (FAK family-interacting protein of 200 kDa), an Atg in autophagy induction, we examined FIP200 interaction with its autophagy partner, Atg13...
April 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/26790962/azide-bridged-cu-ii-mn-ii-and-co-ii-coordination-polymers-constructed-with-a-bifunctional-ligand-of-6-1h-tetrazol-5-yl-2-2-bipyridine
#20
Jung-Yu Tsao, Jia-Dong Tsai, Chen-I Yang
Three new azide-bridged coordination polymers, [M(N3)(tzbp)]n (M = Cu, 1·Cu; Mn, 2·Mn; Co, 3·Co), were successfully synthesized by the introduction of a bifunctional tetrazolate/2,2′-bipyridine ligand, 6-(1H-tetrazol-5-yl)-2,2′-bipyridine (Htzbp), from the in situ [2 + 3] cycloaddition of 6-cyano-2,2′-bipyridine in the presence of an excess of sodium azide under hydrothermal conditions. Compounds 1·Cu−3·Co were characterized by X-ray crystallography, IR spectroscopy, thermogravimetry, and elemental analysis...
February 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
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