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https://www.readbyqxmd.com/read/28631819/protective-effects-of-tannic-acid-on-pressure-overload-induced-cardiac-hypertrophy-and-underlying-mechanisms-in-rats
#1
Li Chu, Pinya Li, Tao Song, Xue Han, Xuan Zhang, Qiongtao Song, Tao Liu, Yuanyuan Zhang, Jianping Zhang
OBJECTIVES: The aim of this study was to examine the cardioprotective effects and latent mechanism of tannic acid (TA) on cardiac hypertrophy. METHODS: Abdominal aortic banding (AAB) was used to induce pressure overload-induced cardiac hypertrophy in male Wistar rats, sham-operated rats served as controls. AAB rats were treated with TA (20 and 40 mg/kg) or captoril. KEY FINDINGS: Abdominal aortic banding rats that received TA showed ameliorated pathological changes in cardiac morphology and coefficients, decreased cardiac hypertrophy and apoptosis, a reduction in over expressions of angiotensin type 1 receptor (AT1 R), angiotensin type 2 receptor (AT2 R), phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and transforming growth factor-β (TGF-β) mRNA, and modified expression of matrix metal proteinase-9 (MMP-9) mRNA in AAB rat hearts...
June 20, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28619110/effect-of-aspartic-acid-and-glutamate-on-metabolism-and-acid-stress-resistance-of-acetobacter-pasteurianus
#2
Haisong Yin, Renkuan Zhang, Menglei Xia, Xiaolei Bai, Jun Mou, Yu Zheng, Min Wang
BACKGROUND: Acetic acid bacteria (AAB) are widely applied in food, bioengineering and medicine fields. However, the acid stress at low pH conditions limits acetic acid fermentation efficiency and high concentration of vinegar production with AAB. Therefore, how to enhance resistance ability of the AAB remains as the major challenge. Amino acids play an important role in cell growth and cell survival under severe environment. However, until now the effects of amino acids on acetic fermentation and acid stress resistance of AAB have not been fully studied...
June 15, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28615718/genome-wide-analyses-of-sweet-family-proteins-reveal-involvement-in-fruit-development-and-abiotic-biotic-stress-responses-in-banana
#3
Hongxia Miao, Peiguang Sun, Qing Liu, Yulu Miao, Juhua Liu, Kaixing Zhang, Wei Hu, Jianbin Zhang, Jingyi Wang, Zhuo Wang, Caihong Jia, Biyu Xu, Zhiqiang Jin
Sugars Will Eventually be Exported Transporters (SWEET) are a novel type of sugar transporter that plays crucial roles in multiple biological processes. From banana, for the first time, 25 SWEET genes which could be classified into four subfamilies were identified. Majority of MaSWEETs in each subfamily shared similar gene structures and conserved motifs. Comprehensive transcriptomic analysis of two banana genotypes revealed differential expression patterns of MaSWEETs in different tissues, at various stages of fruit development and ripening, and in response to abiotic and biotic stresses...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596995/cardiac-myosin-binding-protein-c-autoantibodies-are-potential-early-indicators-of-cardiac-dysfunction-and-patient-outcome-in-acute-coronary-syndrome
#4
Thomas L Lynch, Diederik W D Kuster, Beverly Gonzalez, Neelam Balasubramanian, Nandini Nair, Sharlene Day, Jenna E Calvino, Yanli Tan, Christoph Liebetrau, Christian Troidl, Christian W Hamm, Ahmet Güçlü, Barbara McDonough, Ali J Marian, Jolanda van der Velden, Christine E Seidman, Gordon S Huggins, Sakthivel Sadayappan
The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in CVD patients. Importantly, cMyBP-C-AAbs were significantly detected in ACS patient sera upon arrival to the emergency department, particularly in STEMI patients. Patients positive for cMyBP-C-AAbs had a reduced LVEF and elevated levels of clinical biomarkers of MI...
April 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28595995/mir-146b-probably-assists-mirna-146a-in-the-suppression-of-keratinocyte-proliferation-and-inflammatory-responses-in-psoriasis
#5
Helen Hermann, Toomas Runnel, Alar Aab, Hansjörg Baurecht, Elke Rodriguez, Nathaniel Magilnick, Egon Urgard, Liisi Šahmatova, Ele Prans, Julia Maslovskaja, Kristi Abram, Maire Karelson, Bret Kaldvee, Paula Reemann, Uku Haljasorg, Beate Rückert, Paulina Wawrzyniak, Michael Weichenthal, Ulrich Mrowietz, Andre Franke, Christian Gieger, Jonathan Barker, Richard Trembath, Lam C Tsoi, James T Elder, Eric R Tkaczyk, Kai Kisand, Pärt Peterson, Külli Kingo, Mark Boldin, Stephan Weidinger, Cezmi A Akdis, Ana Rebane
miR-146a inhibits inflammatory responses in human keratinocytes and in different mouse models of skin inflammation. Little is known about the role of miR-146b in the skin. In the present study, we confirmed the increased expression of miR-146a and miR-146b (miR-146a/b) in lesional skin of psoriasis patients. The expression of miR-146a was about 2-fold higher than that of miR-146b in healthy human skin and it was more strongly induced by stimulation of pro-inflammatory cytokines in keratinocytes and fibroblasts...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28576368/efficacy-of-gaseous-ozone-to-counteract-postharvest-table-grape-sour-rot
#6
L Pinto, L Caputo, L Quintieri, S de Candia, F Baruzzi
This work aims at studying the efficacy of low doses of gaseous ozone in postharvest control of the table grape sour rot, a disease generally attributed to a consortium of non-Saccharomyces yeasts (NSY) and acetic acid bacteria (AAB). Sour rot incidence of wounded berries, inoculated with 8 NSYstrains, or 7 AAB, or 56 yeast-bacterium associations, was monitored at 25 °C up to six days. Sour rot incidence in wounded berries inoculated with yeast-bacterium associations resulted higher than in berries inoculated with one single NSY or AAB strain...
September 2017: Food Microbiology
https://www.readbyqxmd.com/read/28557506/correction-to-chun-et-al-2017
#7
(no author information available yet)
Reports an error in "A psychometric investigation of gender differences and common processes across borderline and antisocial personality disorders" by Seokjoon Chun, Alexa Harris, Margely Carrion, Elizabeth Rojas, Stephen Stark, Carl Lejuez, William V. Lechner and Marina A. Bornovalova (Journal of Abnormal Psychology, 2017[Jan], Vol 126[1], 76-88). In the original record, there were two errors in the article's suppemental material. The supplemental material stated, "In each case, if the relaxed model fit significantly better than the baseline model (i...
May 29, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28537647/robotic-assisted-total-hip-arthroplasty-outcomes-at-minimum-two-year-follow-up
#8
Richard L Illgen, Brandon R Bukowski, Rasheed Abiola, Paul Anderson, Morad Chughtai, Anton Khlopas, Michael A Mont
BACKGROUND: Component malposition in total hip arthroplasty (THA) contributes to instability and early failure. Robotic-assisted total hip arthroplasty (rTHA) utilizes CT-based planning with haptically-guided bone preparation and implant insertion to optimize component position accuracy. This study compared acetabular component position and postoperative complications following manual THA (mTHA) with rTHA. MATERIALS AND METHODS: Consecutive primary THAs performed by one surgeon at three intervals were analyzed in this retrospective cohort study: the initial 100 consecutive manual THAs (mTHA) in clinical practice (year 2000), the last consecutive 100 mTHA before rTHA introduction (year 2011), and the first consecutive 100 rTHA (year 2012)...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28526919/antibodies-to-post-translationally-modified-insulin-as-a-novel-biomarker-for-prediction-of-type-1-diabetes-in-children
#9
Rocky Strollo, Chiara Vinci, Nicola Napoli, Paolo Pozzilli, Johnny Ludvigsson, Ahuva Nissim
AIMS/HYPOTHESIS: We have shown that autoimmunity to insulin in type 1 diabetes may result from neoepitopes induced by oxidative post-translational modifications (oxPTM). Antibodies specific to oxPTM-insulin (oxPTM-INS-Ab) are present in most newly diagnosed individuals with type 1 diabetes and are more common than autoantibodies to native insulin. In this study, we investigated whether oxPTM-INS-Ab are present before clinical onset of type 1 diabetes, and evaluated the ability of oxPTM-INS-Ab to identify children progressing to type 1 diabetes...
May 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28503176/impact-of-autoantibodies-against-glycolytic-enzymes-on-pathogenicity-of-autoimmune-retinopathy-and-other-autoimmune-disorders
#10
REVIEW
Grazyna Adamus
Autoantibodies (AAbs) against glycolytic enzymes: aldolase, α-enolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase are prevalent in sera of patients with blinding retinal diseases, such as paraneoplastic [cancer-associated retinopathy (CAR)] and non-paraneoplastic autoimmune retinopathies, as well as in many other autoimmune diseases. CAR is a degenerative disease of the retina characterized by sudden vision loss in patients with cancer and serum anti-retinal AAbs. In this review, we discuss the widespread serum presence of anti-glycolytic enzyme AAbs and their significance in autoimmune diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28432850/a-detailed-experimental-study-of-a-dna-computer-with-two-endonucleases
#11
Sebastian Sakowski, Tadeusz Krasiński, Joanna Sarnik, Janusz Blasiak, Jacek Waldmajer, Tomasz Poplawski
Great advances in biotechnology have allowed the construction of a computer from DNA. One of the proposed solutions is a biomolecular finite automaton, a simple two-state DNA computer without memory, which was presented by Ehud Shapiro's group at the Weizmann Institute of Science. The main problem with this computer, in which biomolecules carry out logical operations, is its complexity - increasing the number of states of biomolecular automata. In this study, we constructed (in laboratory conditions) a six-state DNA computer that uses two endonucleases (e...
April 22, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28428295/multiple-genome-sequences-of-heteropolysaccharide-forming-acetic-acid-bacteria
#12
Julia U Brandt, Frank Jakob, Andreas J Geissler, Jürgen Behr, Rudi F Vogel
We report here the complete genome sequences of the acetic acid bacteria (AAB) Acetobacter aceti TMW 2.1153, A. persici TMW 2.1084, and Neoasaia chiangmaiensis NBRC 101099, which secrete biotechnologically relevant heteropolysaccharides (HePSs) into their environments. Upon genome sequencing of these AAB strains, the corresponding HePS biosynthesis pathways were identified.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28407273/comorbidity-of-chronic-spontaneous-urticaria-and-autoimmune-thyroid-diseases-a-systematic-review
#13
REVIEW
P Kolkhir, M Metz, S Altrichter, M Maurer
Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG antithyroid AAbs (strong evidence)...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28406061/effect-of-packing-material-on-organic-matter-removal-efficiency-in-an-anaerobic-aerobic-baffled-bioreactor
#14
Jacobo Tabla-Hernandez, Edgar Lopez-Galvan
The aim of the present work was to study the effect of packing material on the organic matter removal efficiency (OMRE) in an anaerobic-aerobic baffled bioreactor (AAB). For this purpose, two different experiments were conducted with two types of packing material: activated carbon (AC) particles and polyurethane foam (PF). The system consisted of two treatments; the first one was anaerobic, where hydrolysis, acetogenesis and methanogenesis took place. In anaerobic chambers, there were no packing materials and the operating conditions were the same in both experiments...
May 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28375232/wind-profiling-for-a-coherent-wind-doppler-lidar-by-an-auto-adaptive-background-subtraction-approach
#15
Yanwei Wu, Pan Guo, Siying Chen, He Chen, Yinchao Zhang
Auto-adaptive background subtraction (AABS) is proposed as a denoising method for data processing of the coherent Doppler lidar (CDL). The method is proposed specifically for a low-signal-to-noise-ratio regime, in which the drifting power spectral density of CDL data occurs. Unlike the periodogram maximum (PM) and adaptive iteratively reweighted penalized least squares (airPLS), the proposed method presents reliable peaks and is thus advantageous in identifying peak locations. According to the analysis results of simulated and actually measured data, the proposed method outperforms the airPLS method and the PM algorithm in the furthest detectable range...
April 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28325643/alpha-cells-the-main-source-of-il-1%C3%AE-in-human-pancreas
#16
Florence Anquetil, Somayeh Sabouri, Charles Thivolet, Teresa Rodriguez-Calvo, Jose Zapardiel-Gonzalo, Natalie Amirian, Darius Schneider, Ericka Castillo, Yasaman Lajevardi, Matthias G von Herrath
Interleukin-1β (IL-1β) is known to trigger beta cell dysfunction in vitro and could potentially play a role during the pathogenesis of type 1 diabetes and type 2 diabetes. However, several clinical trials attempting to block IL-1β function have had minimal success. We therefore re-investigated local expression of IL-1β in human diabetic and non-diabetic pancreata. We obtained pancreatic tissue sections from the Network for Pancreatic Organ Donors with Diabetes (nPOD) including non-diabetic (n = 9), non-diabetic auto-antibody positive (AAb+, n = 5), type 1 diabetes (n = 6), and type 2 diabetes (n = 6) donors...
July 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28290848/-autoimmunity-and-prognosis-of-patients-with-morphologically-documented-myocarditis
#17
D A Khashchevskaya, L B Mitrofanova, E A Belyakova, O V Beschuk, D A Zverev, D S Lebedev, O M Moiseeva
AIM: to assess clinical and prognostic value of circulating cardiospecific autoantibodies (AAB) and CD4+ T-regulatory cells in patients with myocarditis. MATERIAL AND METHODS: We included into this study 47 patients with lymphocytic myocarditis verified by analysis of histological and immunohistochemical data. Comparison group consisted of 30 practically healthy persons. Content of marker cardiotropic AAT were measured with the help of standardized immune enzyme test-systems...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28277720/artificial-grammar-learning-in-tamarins-saguinus-oedipus-in-varying-stimulus-contexts
#18
Julie J Neiworth, Justin M London, Michael J Flynn, Deborah D Rupert, Owen Alldritt, Caleb Hyde
The human ability to detect regularities in sound sequences is a fundamental substrate of our language faculty. However, is this an ability exclusive to human language processing, or have we usurped a more general learning mechanism for this purpose, one shared with other species? The current study is an attempt to replicate and extend Hauser, Weiss, and Marcus's (2002) retracted study (2010) of artificial grammar learning in tamarins to determine if tamarins can detect an underlying grammatical structure in a pattern of sounds...
May 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28277014/-you-are-labelled-by-your-children-s-disability-a-community-based-participatory-study-of-stigma-among-somali-parents-of-children-with-autism-living-in-the-united-kingdom
#19
Lucy Ellen Selman, Fiona Fox, Nura Aabe, Katrina Turner, Dheeraj Rai, Sabi Redwood
OBJECTIVES: Social stigma is commonly experienced by parents of children with autism. Our aim was to understand the nature of stigma experienced by Somali parents of children with autism in the United Kingdom (UK), and to consider how they coped with or resisted such stigma. DESIGN: We used a community-based participatory research approach, collaborating with a community organisation of Somali parents. In-depth interviews with simultaneous translation were conducted with 15 Somali parents of children with autism living in Bristol, UK, in 2015...
March 2, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28276515/mri-assessment-of-cardiomyopathy-induced-by-%C3%AE-1-adrenoreceptor-autoantibodies-and-protection-through-%C3%AE-3-adrenoreceptor-overexpression
#20
Laetitia Vanhoutte, Céline Guilbaud, Ruben Martherus, Caroline Bouzin, Bernard Gallez, Chantal Dessy, Jean-Luc Balligand, Stéphane Moniotte, Olivier Feron
The cardiopathogenic role of autoantibodies (aabs) directed against β1-adrenoreceptors (β1-AR) is well established. In mouse models, they cause progressive dilated cardiomyopathy (DCM) whose characterization with echocardiography requires prolonged protocols with numerous animals, complicating the evaluation of new treatments. Here, we report on the characterization of β1-aabs-induced DCM in mice using 11.7T MRI. C57BL/6J mice (n = 10 per group) were immunized against the β1-AR and left ventricular (LV) systolic function was assessed at 10, 18 and 27 weeks...
March 9, 2017: Scientific Reports
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