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https://www.readbyqxmd.com/read/27899902/aggressive-antisocial-behaviors-are-related-to-character-maturity-in-young-swedish-violent-offenders-independent-of-adhd
#1
Thomas Nilsson, Örjan Falk, Eva Billstedt, Nóra Kerekes, Henrik Anckarsäter, Märta Wallinius, Björn Hofvander
BACKGROUND: Antisocial personality and psychopathic traits have constantly been found to accompany criminal and aggressive behaviors, but little attention has been given to aspects of character maturity and its relation to such behaviors. The present study investigated (1) whether level of character maturity (low, medium, and high) is associated with amount of aggressive antisocial behaviors (AABs) and psychopathic traits in young men imprisoned for violent criminality, and (2) whether such an association is independent of coexisting attention-deficit hyperactivity disorder (ADHD)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27886661/bacterial-diversity-shift-determined-by-different-diets-in-the-gut-of-the-spotted-wing-fly-drosophila-suzukii-is-primarily-reflected-on-acetic-acid-bacteria
#2
Violetta Vacchini, Elena Gonella, Elena Crotti, Erica M Prosdocimi, Fabio Mazzetto, Bessem Chouaia, Matteo Callegari, Francesca Mapelli, Mauro Mandrioli, Alberto Alma, Daniele Daffonchio
The pivotal role of diet in shaping gut microbiota has been evaluated in different animal models, including insects. Drosophila flies harbour an inconstant microbiota among which acetic acid bacteria (AAB) are important components. Here, we investigated the bacterial and AAB components of the invasive pest Drosophila suzukii microbiota, by studying the same insect population separately grown on fruit-based or non-fruit artificial diet. AAB were highly prevalent in the gut under both diets (90 and 92% infection rates with fruits and artificial diet, respectively)...
November 25, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27882567/autoantibodies-directed-against-the-endothelin-a-receptor-in-patients-with-benign-prostatic-hyperplasia
#3
Gerd Wallukat, Burkhard Jandrig, Rudolf Kunze, Johann J Wendler, Johannes Müller, Martin Schostak, Ingolf Schimke
BACKGROUND: Over-stimulation of G-protein coupled receptors (GPCRs) such as α1-adrenergic, muscarinic, endothelin, and AT1 receptors is considered to drive benign prostatic hyperplasia (BHP) which is often associated with lower urinary tract syndrome (LUTS). However, in addition to physiologic GPCR ligands, there is a new class of autoantibodies called functional autoantibodies that target the same GPCRs (GPCR-AABs) for over-stimulation, thus, presenting pathogenic potency. We hypothesize that patients with BPH/LUTS could carry GPCR-AABs representing potential targets for treatment...
November 24, 2016: Prostate
https://www.readbyqxmd.com/read/27870985/effect-of-ammonium-and-amino-acids-on-the-growth-of-selected-strains-of-gluconobacter-and-acetobacter
#4
F Sainz, A Mas, M J Torija
Acetic acid bacteria (AAB) are a group of microorganisms highly used in the food industry. However, its use can be limited by the insufficient information known about the nutritional requirements of AAB for optimal growth. The aim of this work was to study the effects of different concentrations and sources of nitrogen on the growth of selected AAB strains and to establish which nitrogen source best encouraged their growth. Two strains of three species of AAB, Gluconobacter japonicus, Gluconobacter oxydans and Acetobacter malorum, were grown in three different media with diverse nitrogen concentrations (25, 50, 100, and 300mgN/L and 1gN/L) as a complete solution of amino acids and ammonium...
November 12, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27858429/testing-hadronic-interactions-at-ultrahigh-energies-with-air-showers-measured-by-the-pierre-auger-observatory
#5
A Aab, P Abreu, M Aglietta, E J Ahn, I Al Samarai, I F M Albuquerque, I Allekotte, J D Allen, P Allison, A Almela, J Alvarez Castillo, J Alvarez-Muñiz, M Ambrosio, G A Anastasi, L Anchordoqui, B Andrada, S Andringa, C Aramo, F Arqueros, N Arsene, H Asorey, P Assis, J Aublin, G Avila, A M Badescu, C Baus, J J Beatty, K H Becker, J A Bellido, C Berat, M E Bertaina, X Bertou, P L Biermann, P Billoir, J Biteau, S G Blaess, A Blanco, J Blazek, C Bleve, H Blümer, M Boháčová, D Boncioli, C Bonifazi, N Borodai, A M Botti, J Brack, I Brancus, T Bretz, A Bridgeman, F L Briechle, P Buchholz, A Bueno, S Buitink, M Buscemi, K S Caballero-Mora, B Caccianiga, L Caccianiga, A Cancio, F Canfora, L Caramete, R Caruso, A Castellina, G Cataldi, L Cazon, R Cester, A G Chavez, A Chiavassa, J A Chinellato, J C Chirinos Diaz, J Chudoba, R W Clay, R Colalillo, A Coleman, L Collica, M R Coluccia, R Conceição, F Contreras, M J Cooper, S Coutu, C E Covault, J Cronin, R Dallier, S D'Amico, B Daniel, S Dasso, K Daumiller, B R Dawson, R M de Almeida, S J de Jong, G De Mauro, J R T de Mello Neto, I De Mitri, J de Oliveira, V de Souza, J Debatin, L Del Peral, O Deligny, N Dhital, C Di Giulio, A Di Matteo, M L Díaz Castro, F Diogo, C Dobrigkeit, J C D'Olivo, A Dorofeev, R C Dos Anjos, M T Dova, A Dundovic, J Ebr, R Engel, M Erdmann, M Erfani, C O Escobar, J Espadanal, A Etchegoyen, H Falcke, K Fang, G R Farrar, A C Fauth, N Fazzini, A P Ferguson, B Fick, J M Figueira, A Filevich, A Filipčič, O Fratu, M M Freire, T Fujii, A Fuster, F Gallo, B García, D Garcia-Pinto, F Gate, H Gemmeke, A Gherghel-Lascu, P L Ghia, U Giaccari, M Giammarchi, M Giller, D Głas, C Glaser, H Glass, G Golup, M Gómez Berisso, P F Gómez Vitale, N González, B Gookin, J Gordon, A Gorgi, P Gorham, P Gouffon, N Griffith, A F Grillo, T D Grubb, F Guarino, G P Guedes, M R Hampel, P Hansen, D Harari, T A Harrison, J L Harton, Q Hasankiadeh, A Haungs, T Hebbeker, D Heck, P Heimann, A E Herve, G C Hill, C Hojvat, N Hollon, E Holt, P Homola, J R Hörandel, P Horvath, M Hrabovský, T Huege, J Hulsman, A Insolia, P G Isar, I Jandt, S Jansen, C Jarne, J A Johnsen, M Josebachuili, A Kääpä, O Kambeitz, K H Kampert, P Kasper, I Katkov, B Keilhauer, E Kemp, R M Kieckhafer, H O Klages, M Kleifges, J Kleinfeller, R Krause, N Krohm, D Kuempel, G Kukec Mezek, N Kunka, A Kuotb Awad, D LaHurd, L Latronico, M Lauscher, P Lautridou, P Lebrun, R Legumina, M A Leigui de Oliveira, A Letessier-Selvon, I Lhenry-Yvon, K Link, L Lopes, R López, A López Casado, A Lucero, M Malacari, M Mallamaci, D Mandat, P Mantsch, A G Mariazzi, V Marin, I C Mariş, G Marsella, D Martello, H Martinez, O Martínez Bravo, J J Masías Meza, H J Mathes, S Mathys, J Matthews, J A J Matthews, G Matthiae, D Maurizio, E Mayotte, P O Mazur, C Medina, G Medina-Tanco, V B B Mello, D Melo, A Menshikov, S Messina, M I Micheletti, L Middendorf, I A Minaya, L Miramonti, B Mitrica, L Molina-Bueno, S Mollerach, F Montanet, C Morello, M Mostafá, C A Moura, G Müller, M A Muller, S Müller, I Naranjo, S Navas, P Necesal, L Nellen, A Nelles, J Neuser, P H Nguyen, M Niculescu-Oglinzanu, M Niechciol, L Niemietz, T Niggemann, D Nitz, D Nosek, V Novotny, H Nožka, L A Núñez, L Ochilo, F Oikonomou, A Olinto, D Pakk Selmi-Dei, M Palatka, J Pallotta, P Papenbreer, G Parente, A Parra, T Paul, M Pech, F Pedreira, J Pękala, R Pelayo, J Peña-Rodriguez, I M Pepe, L A S Pereira, L Perrone, E Petermann, C Peters, S Petrera, J Phuntsok, R Piegaia, T Pierog, P Pieroni, M Pimenta, V Pirronello, M Platino, M Plum, C Porowski, R R Prado, P Privitera, M Prouza, E J Quel, S Querchfeld, S Quinn, J Rautenberg, O Ravel, D Ravignani, B Revenu, J Ridky, M Risse, P Ristori, V Rizi, W Rodrigues de Carvalho, J Rodriguez Rojo, M D Rodríguez-Frías, D Rogozin, J Rosado, M Roth, E Roulet, A C Rovero, S J Saffi, A Saftoiu, H Salazar, A Saleh, F Salesa Greus, G Salina, J D Sanabria Gomez, F Sánchez, P Sanchez-Lucas, E M Santos, E Santos, F Sarazin, B Sarkar, R Sarmento, C Sarmiento-Cano, R Sato, C Scarso, M Schauer, V Scherini, H Schieler, D Schmidt, O Scholten, H Schoorlemmer, P Schovánek, F G Schröder, A Schulz, J Schulz, J Schumacher, S J Sciutto, A Segreto, M Settimo, A Shadkam, R C Shellard, G Sigl, O Sima, A Śmiałkowski, R Šmída, G R Snow, P Sommers, S Sonntag, J Sorokin, R Squartini, D Stanca, S Stanič, J Stapleton, J Stasielak, F Strafella, A Stutz, F Suarez, M Suarez Durán, T Sudholz, T Suomijärvi, A D Supanitsky, M S Sutherland, J Swain, Z Szadkowski, O A Taborda, A Tapia, A Tepe, V M Theodoro, C Timmermans, C J Todero Peixoto, L Tomankova, B Tomé, A Tonachini, G Torralba Elipe, D Torres Machado, P Travnicek, M Trini, R Ulrich, M Unger, M Urban, A Valbuena-Delgado, J F Valdés Galicia, I Valiño, L Valore, G van Aar, P van Bodegom, A M van den Berg, A van Vliet, E Varela, B Vargas Cárdenas, G Varner, J R Vázquez, R A Vázquez, D Veberič, V Verzi, J Vicha, M Videla, L Villaseñor, S Vorobiov, H Wahlberg, O Wainberg, D Walz, A A Watson, M Weber, A Weindl, L Wiencke, H Wilczyński, T Winchen, D Wittkowski, B Wundheiler, S Wykes, L Yang, T Yapici, D Yelos, E Zas, D Zavrtanik, M Zavrtanik, A Zepeda, B Zimmermann, M Ziolkowski, Z Zong, F Zuccarello
Ultrahigh energy cosmic ray air showers probe particle physics at energies beyond the reach of accelerators. Here we introduce a new method to test hadronic interaction models without relying on the absolute energy calibration, and apply it to events with primary energy 6-16 EeV (E_{CM}=110-170  TeV), whose longitudinal development and lateral distribution were simultaneously measured by the Pierre Auger Observatory. The average hadronic shower is 1.33±0.16 (1.61±0.21) times larger than predicted using the leading LHC-tuned models EPOS-LHC (QGSJetII-04), with a corresponding excess of muons...
November 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27858263/-it-was-like-walking-without-knowing-where-i-was-going-a-qualitative-study-of-autism-in-a-uk-somali-migrant-community
#6
Fiona Fox, Nura Aabe, Katrina Turner, Sabi Redwood, Dheeraj Rai
Increasing recognition of autism in Somali migrant communities means that appropriate support services are needed. Attitudes to autism and barriers related to help-seeking in these communities are poorly understood. We aimed to assess what families affected by autism need, and how health, education and social care services can support them. In partnership with the local Somali community the research team conducted 15 in-depth interviews with parents affected by autism. Two themes are reported; 'Perceptions of Autism' and 'Navigating the System'...
November 17, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27853261/cinaciguat-prevents-the-development-of-pathologic-hypertrophy-in-a-rat-model-of-left-ventricular-pressure-overload
#7
Balázs Tamás Németh, Csaba Mátyás, Attila Oláh, Árpád Lux, László Hidi, Mihály Ruppert, Dalma Kellermayer, Gábor Kökény, Gábor Szabó, Béla Merkely, Tamás Radovits
Pathologic myocardial hypertrophy develops when the heart is chronically pressure-overloaded. Elevated intracellular cGMP-levels have been reported to prevent the development of pathologic myocardial hypertrophy, therefore we investigated the effects of chronic activation of the cGMP producing enzyme, soluble guanylate cyclase by Cinaciguat in a rat model of pressure overload-induced cardiac hypertrophy. Abdominal aortic banding (AAB) was used to evoke pressure overload-induced cardiac hypertrophy in male Wistar rats...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27851750/whole-genome-sequence-analysis-of-bombella-intestini-lmg-28161t-a-novel-acetic-acid-bacterium-isolated-from-the-crop-of-a-red-tailed-bumble-bee-bombus-lapidarius
#8
Leilei Li, Koen Illeghems, Simon Van Kerrebroeck, Wim Borremans, Ilse Cleenwerck, Guy Smagghe, Luc De Vuyst, Peter Vandamme
The whole-genome sequence of Bombella intestini LMG 28161T, an endosymbiotic acetic acid bacterium (AAB) occurring in bumble bees, was determined to investigate the molecular mechanisms underlying its metabolic capabilities. The draft genome sequence of B. intestini LMG 28161T was 2.02 Mb. Metabolic carbohydrate pathways were in agreement with the metabolite analyses of fermentation experiments and revealed its oxidative capacity towards sucrose, D-glucose, D-fructose and D-mannitol, but not ethanol and glycerol...
2016: PloS One
https://www.readbyqxmd.com/read/27808543/a-psychometric-investigation-of-gender-differences-and-common-processes-across-borderline-and-antisocial-personality-disorders
#9
Seokjoon Chun, Alexa Harris, Margely Carrion, Elizabeth Rojas, Stephen Stark, Carl Lejuez, William V Lechner, Marina A Bornovalova
The comorbidity between borderline personality disorder (BPD) and antisocial personality disorder (ASPD) is well-established, and the 2 disorders share many similarities. However, there are also differences across disorders: most notably, BPD is diagnosed more frequently in women and ASPD in men. We investigated if (a) comorbidity between BPD and ASPD is attributable to 2 discrete disorders or the expression of common underlying processes, and (b) if the model of comorbidity is true across sex. Using a clinical sample of 1,400 drug users in residential substance abuse treatment, we tested 3 competing models to explore whether the comorbidity of ASPD and BPD should be represented by a single common factor, 2 correlated factors, or a bifactor structure involving a general and disorder-specific factors...
November 3, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27780593/citizen-science-datasets-reveal-drivers-of-spatial-and-temporal-variation-for-anthropogenic-litter-on-great-lakes-beaches
#10
Anna Vincent, Nate Drag, Olga Lyandres, Sarah Neville, Timothy Hoellein
Accumulation of anthropogenic litter (AL) on marine beaches and its ecological effects have been a major focus of research. Recent studies suggest AL is also abundant in freshwater environments, but much less research has been conducted in freshwaters relative to oceans. The Adopt-a-BeachTM (AAB) program, administered by the Alliance for the Great Lakes, organizes volunteers to act as citizen scientists by collecting and maintaining data on AL abundance on Great Lakes beaches. Initial assessments of the AAB records quantified sources and abundance of AL on Lake Michigan beaches, and showed that plastic AL was >75% of AL on beaches across all five Great Lakes...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27769930/synthesis-and-physico-chemical-characterization-of-modified-starches-from-banana-musa-aab-and-its-biological-activities-in-diabetic-rats
#11
Chagam Koteswara Reddy, M Suriya, P V Vidya, Sundaramoorthy Haripriya
This study describes a simple method of preparation and physico-chemical properties of modified starches (type-3 resistant starches) from banana (Musa AAB), and the modified starches investigated as functional food with a beneficial effect on type-2 diabetes. RS3 was prepared using a method combined with debranching modification and physical modification; native and modifies starches were characterized by scanning electron microscope (SEM), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC) and rapid visco analyzer (RVA)...
October 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27730393/privacy-preserving-and-secure-sharing-of-phr-in-the-cloud
#12
Leyou Zhang, Qing Wu, Yi Mu, Jingxia Zhang
As a new summarized record of an individual's medical data and information, Personal Health Record (PHR) can be accessible online. The owner can control fully his/her PHR files to be shared with different users such as doctors, clinic agents, and friends. However, in an open network environment like in the Cloud, these sensitive privacy information may be gotten by those unauthorized parties and users. In this paper, we consider how to achieve PHR data confidentiality and provide fine-grained access control of PHR files in the public Cloud based on Attribute Based Encryption(ABE)...
December 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27726307/high-prevalence-of-diabetes-specific-autoimmunity-in-first-degree-relatives-of-sardinian-patients-with-type-1-diabetes
#13
M Incani, C Serafini, C Satta, L Perra, F Scano, P Frongia, R Ricciardi, C Ripoli, M Soro, A Strazzera, S Zampetti, R Buzzetti, M G Cavallo, E Cossu, M G Baroni
BACKGROUND: The incidence of type 1 diabetes mellitus (T1DM) in Sardinia is among the highest in the world (44.8 cases/100,000 person-years). Recommendations of the Immunology of Diabetes Society advise evaluating autoantibody positivity in first-degree relatives (FDRs) of patients with T1DM, for their higher risk to develop the disease. The aim of this study was to determine the prevalence of beta-cell autoimmunity in FDRs of T1DM patients in Sardinia. METHODS: A total of 188 Sardinian families were recruited in collaboration between diabetes and pediatric units of university and district hospitals in Sardinia...
October 11, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27716345/dissection-of-exopolysaccharide-biosynthesis-in-kozakia-baliensis
#14
Julia U Brandt, Frank Jakob, Jürgen Behr, Andreas J Geissler, Rudi F Vogel
BACKGROUND: Acetic acid bacteria (AAB) are well known producers of commercially used exopolysaccharides, such as cellulose and levan. Kozakia (K.) baliensis is a relatively new member of AAB, which produces ultra-high molecular weight levan from sucrose. Throughout cultivation of two K. baliensis strains (DSM 14400, NBRC 16680) on sucrose-deficient media, we found that both strains still produce high amounts of mucous, water-soluble substances from mannitol and glycerol as (main) carbon sources...
October 4, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27711602/nuclear-spin-hyperpolarization-with-ansa-aminoboranes-a-metal-free-perspective-for-parahydrogen-induced-polarization
#15
Vladimir V Zhivonitko, Kristina Sorochkina, Konstantin Chernichenko, Bianka Kótai, Tamás Földes, Imre Pápai, Ville-Veikko Telkki, Timo Repo, Igor Koptyug
The parahydrogen-induced polarization (PHIP) phenomenon, observed when parahydrogen is used in H2 addition processes, provides a means for substantial NMR signal enhancements and mechanistic studies of chemical reactions. Commonly, noble metal complexes are used for parahydrogen activation, whereas metal-free activation is rare. Herein, we report a series of unimolecular metal-free frustrated Lewis pairs based on an ansa-aminoborane (AAB) moiety in the context of PHIP. These molecules, which have a "molecular tweezers" structure, differ in their substituents at the boryl site (-H, -Ph, -o-iPr-Ph, and -Mes)...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27704289/preadmission-schooling-context-helps-to-predict-examination-performance-throughout-medical-school
#16
Neil Stringer, Michael Chan, Yaw Bimpeh, Philip Chan
This study investigates the effects of socioeconomic status and schooling on the academic attainment of a cohort of students at a single medical school (N = 240). Partial least squares structural equation modelling was used to explore how students' summative assessment scores over 4 years of medical school were affected by: attainment in secondary school examinations (GCSEs and A-levels); the Income Deprivation Affecting Children Index (IDACI) rank associated with students' home postcodes; the performance of students' A-level institutions, measured as the percentage of A-level students achieving 3 A-levels at AAB or higher in two or more facilitating subjects...
October 4, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27701748/effect-of-high-hydrostatic-pressure-on-the-polyphenols-and-antioxidant-activity-of-plantain-pulp-musa-paradisiaca-aab
#17
Miriam C Jiménez-Martínez, Efigenia Montalvo-González, Sonia G Sáyago-Ayerdi, Gilberto Mercado-Mercado, José A Ramírez-de León, Ernestina Paz-Gamboa, Maria A Vivar-Vera
BACKGROUND: The impact of high-pressure processing (HPP) on the polyphenol (PP) content and antioxidant activity (AOX) of plantain pulp was evaluated. Pressures of 400, 500 and 600 MPa were applied to plantain pulp for 90 and 180 s at room temperature (25 °C). Polyphenoloxidase activity, extractable (EPP) and non-extractable PP (NEPP) contents, flavonoid content and AOX (FRAP, ABTS(•+) ) were evaluated. In addition, PP identification was performed using high-performance liquid chromatography...
October 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27690455/tracking-the-antibody-immunome-in-type-1-diabetes-using-protein-arrays
#18
Xiaofang Bian, Clive Wasserfall, Garrick Wallstrom, Jie Wang, Haoyu Wang, Kristi Barker, Desmond Schatz, Mark Atkinson, Ji Qiu, Joshua LaBaer
We performed an unbiased proteome-scale profiling of humoral autoimmunity in recent-onset type 1 diabetes (T1D) patients and non-diabetic controls against ~10,000 human proteins using a Nucleic Acid Programmable Protein Array (NAPPA) platform, complemented by a knowledge-based selection of proteins from genes enriched in human pancreas. Although the global response was similar between cases and controls, we identified and then validated six specific novel T1D-associated autoantibodies (AAbs) with sensitivities that ranged from 16% to 27% at 95% specificity...
October 3, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27625643/determination-of-dehydrogenase-activities-involved-in-d-glucose-oxidation-in-gluconobacter-and-acetobacter-strains
#19
Florencia Sainz, María Jesús Torija, Minenosuke Matsutani, Naoya Kataoka, Toshiharu Yakushi, Kazunobu Matsushita, Albert Mas
Acetic acid bacteria (AAB) are known for rapid and incomplete oxidation of an extensively variety of alcohols and carbohydrates, resulting in the accumulation of organic acids as the final products. These oxidative fermentations in AAB are catalyzed by PQQ- or FAD- dependent membrane-bound dehydrogenases. In the present study, the enzyme activity of the membrane-bound dehydrogenases [membrane-bound PQQ-glucose dehydrogenase (mGDH), D-gluconate dehydrogenase (GADH) and membrane-bound glycerol dehydrogenase (GLDH)] involved in the oxidation of D-glucose and D-gluconic acid (GA) was determined in six strains of three different species of AAB (three natural and three type strains)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27617966/anti-ephrin-type-b-receptor-2-ephb2-and-anti-three-prime-histone-mrna-exonuclease-1-thex1-autoantibodies-in-scleroderma-and-lupus
#20
Doua F Azzouz, Gabriel V Martin, Fanny Arnoux, Nathalie Balandraud, Thierry Martin, Sylvain Dubucquoi, Eric Hachulla, Dominique Farge-Bancel, Kiet Tiev, Jean Cabane, Nathalie Bardin, Laurent Chiche, Marielle Martin, Eléonore C Caillet, Sami B Kanaan, Jean Robert Harlé, Brigitte Granel, Elisabeth Diot, Jean Roudier, Isabelle Auger, Nathalie C Lambert
In a pilot ProtoArray analysis, we identified 6 proteins out of 9483 recognized by autoantibodies (AAb) from patients with systemic sclerosis (SSc). We further investigated the 6 candidates by ELISA on hundreds of controls and patients, including patients with Systemic Lupus Erythematosus (SLE), known for high sera reactivity and overlapping AAb with SSc. Only 2 of the 6 candidates, Ephrin type-B receptor 2 (EphB2) and Three prime Histone mRNA EXonuclease 1 (THEX1), remained significantly recognized by sera samples from SSc compared to controls (healthy or with rheumatic diseases) with, respectively, 34% versus 14% (P = 2...
2016: PloS One
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