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https://www.readbyqxmd.com/read/29308305/early-detection-of-lung-cancer-by-using-an-autoantibody-panel-in-chinese-population
#1
Shengxiang Ren, Shucai Zhang, Tao Jiang, Yayi He, Zhiyong Ma, Hourong Cai, Xiaohong Xu, Yan Li, Weijing Cai, Jing Zhou, Xiaopeng Liu, Xuejun Hu, Jun Zhang, Hui Yu, Caicun Zhou, Fred R Hirsch
We have previously identified a panel of autoantibodies (AABs), including p53, GAGE7, PGP9.5, CAGE, MAGEA1, SOX2 and GBU4-5, that was helpful in the early diagnosis of lung cancer. This large-scale, multicenter study was undertaken to validate the clinical value of this 7-AABs panel for early detection of lung cancer in a Chinese population. Two independent sets of plasma samples from 2308 participants were available for the assay of AABs (training set = 300; validation set = 2008). The concentrations of AABs were quantitated by enzyme-linked immunosorbent assay (ELISA), and the optimal cutoff value for each AAB was determined in the training set and then applied in the validation set...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29244839/direct-and-indirect-climate-controls-predict-heterogeneous-early-mid-21st-century-wildfire-burned-area-across-western-and-boreal-north-america
#2
Thomas Kitzberger, Donald A Falk, Anthony L Westerling, Thomas W Swetnam
Predicting wildfire under future conditions is complicated by complex interrelated drivers operating across large spatial scales. Annual area burned (AAB) is a useful index of global wildfire activity. Current and antecedent seasonal climatic conditions, and the timing of snowpack melt, have been suggested as important drivers of AAB. As climate warms, seasonal climate and snowpack co-vary in intricate ways, influencing fire at continental and sub-continental scales. We used independent records of seasonal climate and snow cover duration (last date of permanent snowpack, LDPS) and cell-based Structural Equation Models (SEM) to separate direct (climatic) and indirect (snow cover) effects on relative changes in AAB under future climatic scenarios across western and boreal North America...
2017: PloS One
https://www.readbyqxmd.com/read/29204916/rnaseh1-gene-variants-are-associated-with-autoimmune-type-1-diabetes-in-colombia
#3
N Pineda-Trujillo, A Rodríguez-Acevedo, A Rodríguez, A Ruíz-Linares, G Bedoya, A Rivera, J-M Alfaro
BACKGROUND: In a previous work, we found linkage and association of type 1 diabetes (T1D) to a 12 known gene region at chromosome 2p25 in Colombian families. Here, we present further work on this candidate region. MATERIALS AND METHODS: Seventeen SNPs located on the 12 candidate genes, in 100 familial trios set, were tested by ARMS-tetraprimer-PCR or PCR-RFLP. Five extra SNPs in the vicinity of rs10186193 were typed. A replica phase included 97 novel familial trios, in whom diabetes-related auto-antibodies (AABs) were tested in sera of the patients...
December 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29171660/relationship-between-degree-of-obstruction-and-airflow-limitation-in-subglottic-stenosis
#4
Emily L Lin, Jonathan M Bock, Carlton J Zdanski, Julia S Kimbell, Guilherme J M Garcia
OBJECTIVES: Subglottic stenosis (SGS) is one of the most common airway disorders in pediatric patients. Currently, treatment decisions rely primarily on the Cotton-Myer scale, which classifies SGS severity based on percentage reduction in airspace cross-sectional area (CSA). However, the precise relationship between upper airway resistance and subglottic CSA is unknown. We hypothesize that airway resistance can be described by the Bernoulli Obstruction Theory, which predicts that airway resistance is inversely proportional to airspace CSA ( R∝A-1) in cases of severe constriction...
November 24, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29141850/autoantibodies-against-hsf1-and-ccdc155-as-biomarkers-of-early-stage-high-grade-serous-ovarian-cancer
#5
Amy L Wilson, Laura R Moffitt, Nadine Duffield, Adam Rainczuk, Tom W Jobling, Magdalena Plebanski, Andrew N Stephens
BACKGROUND: Tumor-directed circulating autoantibodies (AAbs) are a well-established feature of many solid tumor types, and are often observed prior to clinical disease manifestation. As such, they may provide a good indicator of early disease development. We have conducted a pilot study to identify novel AAbs as markers of early stage HGSOCs. METHODS: A rare cohort of patients with early (FIGO stage Ia-c) HGSOCs for IgG, IgA and IgM-mediated AAb reactivity using high content protein arrays (containing 9184 individual proteins)...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29082398/stacking-enriched-magneto-transport-properties-of-few-layer-graphenes
#6
Thi-Nga Do, Cheng-Peng Chang, Po-Hsin Shih, Jhao-Ying Wu, Ming-Fa Lin
The quantum Hall effects in sliding bilayer graphene and a AAB-stacked trilayer system are investigated using the Kubo formula and a generalized tight-binding model. The various stacking configurations can greatly diversify the magnetic quantization and thus create rich and unique transport properties. The quantum conductivities are very sensitive to the Fermi energy and magnetic-field strength. The diverse features cover the specific non-integer conductivities, the integer conductivities with distinct steps, the splitting-created reduction and complexity of quantum conductivity, a vanishing or non-zero conductivity at the neutral point, and the well-like, staircase, composite, and abnormal plateau structures in the field dependencies...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29062084/comparative-network-analysis-of-patients-with-non-small-cell-lung-cancer-and-smokers-for-representing-potential-therapeutic-targets
#7
Mehrdad Pazhouhandeh, Fatemeh Samiee, Tahereh Boniadi, Abbas Fadaei Khedmat, Ensieh Vahedi, Mahsa Mirdamadi, Naseh Sigari, Seyed Davar Siadat, Farzam Vaziri, Abolfazl Fateh, Faezeh Ajorloo, Elham Tafsiri, Mostafa Ghanei, Fereidoun Mahboudi, Fatemeh Rahimi Jamnani
Cigarette smoking is the leading cause of lung cancer worldwide. In this study, we evaluated the serum autoantibody (AAb) repertoires of non-small cell lung cancer (NSCLC) patients and smokers (SM), leading to the identification of overactivated pathways and hubs involved in the pathogenesis of NSCLC. Surface- and solution-phase biopanning were performed on immunoglobulin G purified from the sera of NSCLC and SM groups. In total, 20 NSCLC- and 12 SM-specific peptides were detected, which were used to generate NSCLC and SM protein datasets...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050592/eco-friendly-films-prepared-from-plantain-flour-pcl-blends-under-reactive-extrusion-conditions-using-zirconium-octanoate-as-a-catalyst
#8
Tomy J Gutiérrez, Vera A Alvarez
Plantain flour (Musa ssp., group AAB, sub-group clone Harton)/poly(ε-caprolactone) (PCL) blends, containing glycerol as a plasticizer, were prepared by reactive extrusion (REx) in a twin-screw extruder using zirconium octanoate (Zr(Oct)4) as a catalyst, followed by thermo-compression molding for film development. The films were then characterized in terms of their: infrared (FTIR) spectra, water solubility, thermogravimetric (TGA) curves, differential scanning calorimetry (DSC) thermograms, and X-ray diffraction (XDR) diffractograms, as well as their microstructural, mechanical and antimicrobial properties in order to (1) compare the effects of PCLs with two different molecular weights (Mw) on the characteristics of the plantain flour/PCL blends, and (2) determine whether using Zr(Oct)4 in the production of active composite polymer materials improves their properties...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29019047/autoantibodies-against-interleukin-21-correlate-with-disease-activity-in-patients-with-rheumatoid-arthritis
#9
Rui Xing, Lin Sun, Dong Wu, Yinji Jin, Changhong Li, Xiangyuan Liu, Jinxia Zhao
The objective of this study is to investigate the levels of interleukin (IL)-21 and autoantibodies (AAbs) against IL-21 and their association with clinical characteristics and laboratory parameters in patients with rheumatoid arthritis (RA). One hundred twenty-six patients with RA, 69 patients with osteoarthritis (OA), and 88 healthy controls (HC) were included in this study. The levels of IL-21 and AAbs against IL-21 in the serum were measured using enzyme-linked immunosorbent assay (ELISA). The correlation between the levels of IL-21 and anti-IL-21 AAbs with clinical and laboratory parameters was evaluated...
October 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28992303/dominant-allele-phylogeny-and-constitutive-subgenome-haplotype-inference-in-bananas-using-mitochondrial-and-nuclear-markers
#10
Kariuki Samwel Muiruri, Anne Britt, Nelson Onzere Amugune, Edward Nguu, Simon Chan, Leena Tripathi
Cultivated bananas (Musa spp.) have undergone domestication patterns involving crosses of wild progenitors followed by long periods of clonal propagation. Majority of cultivated bananas are polyploids with different constitutive subgenomes and knowledge on phylogenies to their progenitors at the species and subspecies levels is essential. Here, the mitochondrial (NAD1) and nuclear (CENH3) markers were used to phylogenetically position cultivated banana genotypes to diploid progenitors. The CENH3 nuclear marker was used to identify a minimum representative haplotype number in polyploids and diploid bananas based on single nucleotide polymorphisms...
October 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28965575/severe-selenium-deficits-in-pregnant-women-irrespective-of-autoimmune-thyroid-disease-in-an-area-with-marginal-selenium-intake
#11
Urszula Ambroziak, Sandra Hybsier, Urszula Shahnazaryan, Małgorzata Krasnodębska-Kiljańska, Eddy Rijntjes, Zbigniew Bartoszewicz, Tomasz Bednarczuk, Lutz Schomburg
OBJECTIVES: Selenium (Se) deficiency is related to an increased risk of preterm labor, miscarriage, preeclampsia, gestational diabetes, and other obstetric complications. As the Se status declines during pregnancy, we hypothesized that the decline may be exacerbated in women with autoimmune thyroid disease (AITD). MATERIAL AND METHODS: Pregnant women (n=74; 30 [23-38] years) were consecutively recruited from the district of Warsaw, Poland, and divided into healthy subjects (HS, n=45), and women with a diagnosis of AITD (AITD, n=29)...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28960523/eryptosis-in-autoimmune-haemolytic-anaemia
#12
Thilo Bartolmäs, Beate Mayer, Abdelwahab H Balola, Abdulgabar Salama
OBJECTIVE: Haemolysis and anaemia related to autoimmune haemolytic anaemia (AIHA) of warm type (wAIHA) and of cold type (cAIHA) are believed to be solely due to antibody and/or complement-mediated destruction and clearance of red blood cells (RBCs). There is evidence that RBCs of affected patients may also undergo eryptosis, the suicidal death of RBCs. METHOD: RBCs from 24 patients with wAIHA, 7 patients with chronic cAIHA, and one patient with AIHA of mixed-type were analysed for exposed phosphatidylserine (PS) by treatment with phycoerythrin (PE)-labelled Annexin V and cell-associated fluorescence was measured using a MACSQuant flow cytometer...
September 27, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28951328/autoantibodies-of-igm-and-igg-classes-show-differences-in-recognition-of-multiple-autoantigens-in-chronic-obstructive-pulmonary-disease
#13
Reham Shindi, Amna Almehairi, Ola H Negm, Noor Kalsheker, Nichola S Gale, Dennis J Shale, Timothy W Harrison, Charlotte E Bolton, Michelle John, Ian Todd, Patrick J Tighe, Lucy C Fairclough
Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of smoking without COPD. All COPD patients' sera contained elevated levels of AAbs to some of 30 autoantigens. There were significant differences in the autoantigenic specificities of IgM AAbs compared to IgG AAbs in the COPD sera: for example, AAbs to histone and scl-70 were mainly IgG, whereas AAbs to CENP-B and La/ssB were mainly IgM; by contrast, IgM and IgG AAbs to collagen-V were equally prevalent...
October 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28932219/improving-acetic-acid-production-by-over-expressing-pqq-adh-in-acetobacter-pasteurianus
#14
Xuefeng Wu, Hongli Yao, Lili Cao, Zhi Zheng, Xiaoju Chen, Min Zhang, Zhaojun Wei, Jieshun Cheng, Shaotong Jiang, Lijun Pan, Xingjiang Li
Pyrroquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) is a key enzyme in the ethanol oxidase respiratory chain of acetic acid bacteria (AAB). To investigate the effect of PQQ-ADH on acetic acid production by Acetobacter pasteurianus JST-S, subunits I (adhA) and II (adhB) of PQQ-ADH were over-expressed, the fermentation parameters and the metabolic flux analysis were compared in the engineered strain and the original one. The acetic acid production was improved by the engineered strain (61.42 g L(-1)) while the residual ethanol content (4...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28926965/glycemic-responses-glycemic-index-and-glycemic-load-values-of-some-street-foods-prepared-from-plantain-musa-spp-aab-genome-in-c%C3%A3-te-d-ivoire
#15
Camille Adam Kouamé, Nestor Kouakou Kouassi, Denis Yao N'dri, Kingsley Kwadwo Asare Pereko, Maria Cristina Casiraghi, Abodo Jacko Rhedoor, Georges N'guessan Amani
The glycemic index (GI) and glycemic load (GL) of four culinary preferences including five local street dishes prepared from three varieties of plantain at different maturity stages was determined. The GI was obtained following ISO/FDI 26642:2010 protocol, and the GL was calculated from test foods' GI, considering the amount of available carbohydrate in the traditional portion size. GI values were 44 for Klaclo (with Ameletiha variety at all black stage), 39 for Aloco (with Agnrin variety at full yellow stage), 39 for Aloco (with Agnrin variety at full yellow with black spots stage); 45 for Chips (with Ameletiha variety at green stage) and 89 for Banane braisée (with Afoto variety at light green stage)...
September 16, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28889055/cells-qpcr-as-a-direct-quantitative-pcr-method-to-avoid-microbial-dna-extractions-in-grape-musts-and-wines
#16
Verónica Soares-Santos, Isabel Pardo, Sergi Ferrer
A novel quantitative PCR assay called Cells-qPCR has been developed for the rapid detection and quantification of yeasts, lactic acid bacteria (LAB) and acetic acid bacteria (AAB) directly from grape must and wine that does not require DNA extraction. The assay was tested on Brettanomyces bruxellensis, Saccharomyces cerevisiae, Lactobacillus plantarum, Oenococcus oeni, Acetobacter aceti and Gluconobacter oxydans in culture media, and in white and red grape musts and wines. Standard curves were constructed from DNA and cells for the six target species in all the matrices...
September 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28863341/acetic-acid-bacteria-in-fermented-foods-and-beverages
#17
REVIEW
Jonas De Roos, Luc De Vuyst
Although acetic acid bacteria (AAB) are commonly found in spontaneous or backslopped fermented foods and beverages, rather limited knowledge about their occurrence and functional role in natural food fermentation ecosystems is available. Not only is their cultivation, isolation, and identification difficult, their cells are often present in a viable but not culturable state. Yet, they are promising starter cultures either to better control known food fermentation processes or to produce novel fermented foods and beverages...
August 29, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28822049/potential-for-diagnosis-versus-therapy-monitoring-of-attention-deficit-hyperactivity-disorder-a-new-epigenetic-biomarker-interacting-with-both-genotype-and-auto-immunity
#18
Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addario
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5'-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporter (DAT). We analysed buccal swabs and sera from 30 children who met DSM-IV-TR criteria for ADHD, assigned to treatment according to severity. Methylation levels at six-selected CpG sites (among which, a CGGCGGCGG and a CGCG motif), alone or in combination with serum titers in auto-antibodies against dopamine transporter (DAT aAbs), were analysed for correlation with CGAS scores (by clinicians) and Conners' scales (by parents), collected at recruitment and after 6 weeks...
August 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28800944/systematic-review-tumor-associated-antigen-autoantibodies-and-ovarian-cancer-early-detection
#19
REVIEW
Renée Turzanski Fortner, Antje Damms-Machado, Rudolf Kaaks
OBJECTIVES: Tumor-associated autoantibodies (AAbs), produced as an immune response to tumor-associated antigens (TAAs), are a novel pathway of early detection markers. METHODS: We conducted a systematic review on AAbs and ovarian cancer to summarize the diagnostic performance of individual AAbs and AAb panels. A total of 29 studies including 85 AAbs were included; 27 of the studies were conducted in prevalent cases and cancer-free controls and 2 investigations included pre-diagnosis samples...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28724905/flowering-time-in-banana-musa-spp-a-day-neutral-plant-is-controlled-by-at-least-three-flowering-locus-t-homologues
#20
Akhilesh K Chaurasia, Hemant B Patil, Bal Krishna, V R Subramaniam, Prafullachandra V Sane, Aniruddha P Sane
Banana is an important day neutral food crop with a long flowering/fruiting cycle that is affected by hot summers or cold winters in different places. Manipulating its life cycle requires an understanding of its flowering time machinery to bypass these stresses. Twelve FLOWERING LOCUS T (FT) and two TWIN SISTER OF FT (TSF) members were isolated from banana and their organization and expression pattern studied during development in two varieties that differ in flowering time namely Grand Nain (AAA genotype) and Hill banana (AAB genotype)...
July 19, 2017: Scientific Reports
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