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https://www.readbyqxmd.com/read/28078212/improvement-of-endothelial-function-following-initiation-of-testosterone-replacement-therapy
#1
Daniel A Shoskes, Barbara Tucky, Allan S Polackwich
BACKGROUND: Isolated recent studies have suggested an increased risk of heart attack as early as 3 months following testosterone replacement therapy (TRT). Such a rapid risk increase would likely require rapid deterioration of arterial endothelial function. Our goal was to assess arterial endothelial function in hypogonadal men prior to and at least 3 months after initiation of TRT. METHODS: Adult men were consented if they had symptoms of hypogonadism, a total testosterone <350 ng/dL, and planned to begin TRT...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28056981/arterial-stiffness-endothelial-and-cognitive-function-in-subjects-with-type-2-diabetes-in-accordance-with-absence-or-presence-of-diabetic-foot-syndrome
#2
Antonino Tuttolomondo, Alessandra Casuccio, Giovanni Guercio, Carlo Maida, Alessandro Del Cuore, Domenico Di Raimondo, Irene Simonetta, Danilo Di Bona, Rosaria Pecoraro, Vittoriano Della Corte, Eliana Gulotta, Gaspare Gulotta, Antonio Pinto
BACKGROUND: Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic foot is associated with arterial stiffness and endothelial function impairment. METHODS: We studied 50 subjects with type 2 diabetes mellitus and diabetic foot syndrome (DFS) compared to 50 diabetic subjects without diabetic foot, and 53 patients without diabetes mellitus, by means of the mini mental state examination (MMSE) administered to evaluate cognitive performance...
January 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28040274/night-time-blood-pressure-variability-negatively-correlated-with-reactive-hyperemia-index
#3
Yuichi Saito, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi
No abstract text is available yet for this article.
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28036158/premature-atherosclerosis-in-systemic-sclerosis-patients-its-relation-to-disease-parameters-and-to-traditional-risk-factors
#4
Manal M Sedky Abdou, Soha M El Desouky, Khaled M Helmy El Kaffas, Abeer M Ahmed Hassan
AIM: To detect premature atherosclerosis in systemic sclerosis (SSc) patients and its relation to disease parameters and traditional risk factors. METHOD: This study included 40 SSc patients and 40 healthy age and sex matched controls. All patients were subjected to full history taking, clinical examination, relevant laboratory and radiological investigations. Doppler ultrasonography (US) of the common carotid was performed to measure intima-media thickness (ccIMT) and Doppler US of the brachial artery was performed to measure flow mediated dilatation (FMD)...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28032371/tadalafil-for-male-lower-urinary-tract-symptoms-improves-endothelial-function
#5
Kazuhiko Fukumoto, Atsushi Nagai, Ryoei Hara, Tomohiro Fujii, Yoshiyuki Miyaji
OBJECTIVES: To investigate the effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia. METHODS: Tadalafil 5 mg was given to 20 patients with prostatic hyperplasia for whom an α1-blocker was ineffective. Voiding symptoms and vascular endothelial function were investigated before and after 4 and 12 weeks of administration, using commercial tests for vascular function and vascular endothelial function. RESULTS: The participants had a median age of 65 years, a mean body mass index of 24...
December 29, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28004456/maternal-endothelial-function-and-vascular-stiffness-after-hellp-syndrome-a-case-control-study
#6
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Federico Prefumo, Adriana Valcamonico, Marco Metra, Tiziana Frusca
OBJECTIVES: To assess endothelial function and arterial stiffness in women with a previous pregnancy complicated by haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and compare them with women with a previous preeclampsia (PE) without HELLP and controls with uncomplicated pregnancies. METHODS: Women who have had a singleton pregnancy complicated by PE with (n = 49) or without (n = 60) HELLP syndrome and controls (n = 60) underwent peripheral arterial tonometry (EndoPAT method) and pulse wave velocity (PWV) assessment at 6 months-4 years after delivery...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28001011/deterioration-of-endothelial-function-of-micro-and-macrocirculation-in-patients-with-diabetes-type-1-and-2
#7
Hana Besic, Luka Jeraj, Ana Spirkoska, Mateja K Jezovnik, Pavel Poredos
BACKGROUND: Vascular complications are an important cause of morbidity in patients with diabetes mellitus (DM). Endothelial dysfunction is an early marker of atherosclerosis and has already been shown in macrocirculation of diabetic patients, however, data on endothelial function of microcirculation is scarce. Our aim was to evaluate endothelial function in macro- and microcirculation and their interrelationship in patients with type 1 and 2 DM. METHODS: The study included 30 patients with type 1 DM, 30 patients with type 2 DM and 25 healthy controls...
December 20, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27993753/reactive-myocardial-hyperemia-for-functional-assessment-of-coronary-stenosis-severity
#8
Michael Stoller, Christian Seiler
AIM: To compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement as induced by systemic adenosine and by regional reactive myocardial hyperemia. METHODS AND RESULTS: The primary study endpoints were coronary pressure-derived FFR values in response to intravenous adenosine infusion (140µg/min/kg) and to a 1-minute proximal coronary artery balloon occlusion (reactive hyperemia) for the same stenosis of interest. The secondary study endpoint was coronary collateral flow index (CFI) during the same occlusion...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27871219/relationship-between-endothelial-function-of-micro-and-macrocirculation-in-patients-with-peripheral-arterial-disease
#9
Pavel Poredoš, Hana Bešič, Luka Jeraj
BACKGROUND: In the pathogenesis of peripheral arterial occlusive disease (PAD), different risk factors of atherosclerosis are involved which stimulate the development of the functional and morphological deterioration of vessel walls in macro- and microcirculation. The endothelial dysfunction (ED) of macrovessels has been proven, however, data on ED in microcirculation are sparse. Therefore, we have studied the relationship between micro- and macrocirculation in PAD patients. PATIENTS AND METHODS: The study included 85 participants: 30 patients had PAD without diabetes mellitus, 30 patients had PAD and diabetes mellitus type 2, and 25 were healthy controls...
November 24, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27861629/the-relationship-between-endothelial-dysfunction-and-endothelial-cell-markers-in-peripheral-arterial-disease
#10
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
INTRODUCTION: The endothelial function plays key roles in both promoting and protecting against atherosclerotic disease. Several methods, including peripheral arterial tonometry (PAT), have been reported to be useful for investigating endothelial dysfunction. Furthermore, the level of thrombomodulin (TM) is assumed to reflect the endothelial dysfunction. In the present study, we investigated endothelial dysfunction in patients with peripheral arterial disease (PAD) by measuring their TM levels, and evaluated the correlation between TM and various parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27853624/endothelial-dysfunction-of-patients-with-peripheral-arterial-disease-measured-by-peripheral-arterial-tonometry
#11
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
Objective. Endothelial dysfunction plays a key role in atherosclerotic disease. Several methods have been reported to be useful for evaluating the endothelial dysfunction, and we investigated the endothelial dysfunction in patients with peripheral arterial disease (PAD) using peripheral arterial tonometry (PAT) test in this study. Furthermore, we examined the factors significantly correlated with PAT test. Methods. We performed PAT tests in 67 patients with PAD. In addition, we recorded the patients' demographics, including comorbidities, and hemodynamical status, such as ankle brachial pressure index (ABI)...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/27843051/effect-of-hormone-replacement-therapy-with-the-anti-mineralocorticoid-progestin-drospirenone-compared-to-tibolone-on-endothelial-function-and-central-haemodynamics-in-post-menopausal-women
#12
Cristiana Vitale, Caterina Mammi, Marco Gambacciani, Novella Russo, Ilaria Spoletini, Massimo Fini, Maurizio Volterrani, Giuseppe M C Rosano
Drospirenone (DRSP) is an antialdosterone agent with progestogenic and antiandrogenic effects. This compound, has been recently used in combination with 17β-estradiol (E2) as hormonal therapy in postmenopausal women and has been shown to exert a significant antihypertensive effect in hypertensive post-menopausal women. Aim of the present study was to compare the effect of DRSP/E2 with those of Tibolone (T) on endothelial function, arterial stiffness, and lipid profile of early postmenopausal women naïve on post-menopausal hormonal therapy...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27823688/the-effect-of-fresh-versus-standard-blood-transfusion-on-microvascular-endothelial-function
#13
Yasir Parviz, Cyrus Hsia, Mistre Alemayehu, Sabrina Wall, Rodrigo Bagur, Nour AbuRomeh, Ian Chin-Yee, Shahar Lavi
BACKGROUND: The duration of red blood cell (RBC) storage may have a negative impact on endothelial nitric oxide bioavailability. We tested the hypothesis that transfused fresh blood will have a more favorable effect on microvascular endothelial function as compared to older standard issue blood. METHODS: Participants requiring chronic RBC transfusions were enrolled in a crossover design study to receive fresh (<7 days of storage) or standard (up to 42 days of storage) blood on 2 separate visits...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27818472/a-single-session-of-neuromuscular-electrical-stimulation-enhances-vascular-endothelial-function-and-peripheral-blood-circulation-in-patients-with-acute-myocardial-infarction
#14
Shinya Tanaka, Takashi Masuda, Kentaro Kamiya, Nobuaki Hamazaki, Ayako Akiyama, Yumi Kamada, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Junya Ako
This study aimed to investigate whether a single session of neuromuscular electrical stimulation (NMES) can enhance vascular endothelial function and peripheral blood circulation in patients with acute myocardial infarction (AMI). Thirty-four male patients with AMI were alternately assigned to 2 groups, and received NMES with muscle contraction (NMES group, n = 17) or without muscle contraction (control group, n = 17) after admission. NMES was performed for quadriceps and gastrocnemius muscles of both legs for 30 minutes...
December 2, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27817840/endothelial-function-and-arterial-stiffness-indexes-in-subjects-with-acute-ischemic-stroke-relationship-with-toast-subtype
#15
Antonino Tuttolomondo, Alessandra Casuccio, Vittoriano Della Corte, Carlo Maida, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Irene Simonetta, Valentina Arnao, Antonio Pinto
BACKGROUND AND AIMS: Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification...
October 29, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27803400/excess-visceral-adipose-tissue-worsens-the-vascular-endothelial-function-in-patients-with-type-2-diabetes-mellitus
#16
Akira Kurozumi, Yosuke Okada, Tadashi Arao, Yoshiya Tanaka
Objective Visceral fat obesity and metabolic syndrome correlate with atherosclerosis in part due to insulin resistance and various other factors. The aim of this study was to determine the relationship between vascular endothelial dysfunction and excess visceral adipose tissue (VAT) in Japanese patients with type 2 diabetes mellitus (T2DM). Methods In 71 T2DM patients, the reactive hyperemia index (RHI) was measured using an Endo-PAT 2000, and VAT and subcutaneous adipose tissue (SAT) were measured via CT. We also measured various metabolic markers, including high-molecular-weight adiponectin (HMW-AN)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27797674/effect-of-soy-in-men-with-type-2-diabetes-mellitus-and-subclinical-hypogonadism-a-randomized-controlled-study
#17
Thozhukat Sathyapalan, Alan S Rigby, Shalender Bhasin, Natalie J Thatcher, Eric S Kilpatrick, Stephen L Atkin
CONTEXT: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to hypogonadism. OBJECTIVE: The primary outcome was change in total testosterone levels. The secondary outcomes were the changes in glycaemia and cardiovascular risk markers. DESIGN: Randomised double blind parallel study...
October 31, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27766047/microrna-in-atherothromobosis-is-it-useful-as-a-disease-marker
#18
Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27758140/association-of-lipoprotein-subfractions-with-endothelial-function-and-arterial-stiffness-in-acute-ischemic-stroke
#19
Pavel Šiarnik, Zuzana Čarnická, Zuzana Krivošíková, Katarína Klobučníková, Ingrid Žitňanová, Branislav Kollár, Marek Sýkora, Peter Turčáni
Hypercholesterolemia represents a risk factor for the development of atherosclerosis. Lipoprotein research has recently been focused on the phenomenon of atherogenic and non-atherogenic lipoproteins. The aim of this study was to explore the association of lipoprotein subfractions with a measure for endothelial function (represented by reactive hyperemia index [RHI]) and arterial stiffness (represented by augmentation index [AI]) in patients with acute ischemic stroke. We enrolled 51 patients with acute ischemic stroke...
February 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27731532/a-longitudinal-study-of-vascular-structure-and-function-during-normal-pregnancy
#20
Charlotte Iacobaeus, Ellika Andolf, Malin Thorsell, Katarina Bremme, Gun JÖrneskog, Eva Östlund, Thomas Kahan
OBJECTIVE: To examine alterations in maternal vascular structure and function during normal pregnancy. METHODS: We assessed brachial and central blood pressure, pulse wave velocity and augmentation index (by pulse wave analysis and applanation tonometry), common carotid artery structure (by ultrasonography), and endothelial function in the brachial artery (by post-ischemic hyperemia induced flow mediated vasodilation and glyceryl nitrate) and in the forearm skin microcirculation (by laser Doppler perfusion imaging during iontophoretic administration of acetylcholine and sodium nitroprusside) in 52 healthy primiparous women at 14, 24 and 34 weeks of gestation, and nine months post partum...
October 12, 2016: Ultrasound in Obstetrics & Gynecology
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