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reactive hyperemia index

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https://www.readbyqxmd.com/read/28329397/resveratrol-improves-vascular-function-and-mitochondrial-number-but-not-glucose-metabolism-in-older-adults
#1
Rena M Pollack, Nir Barzilai, Valentin Anghel, Ameya S Kulkarni, Aaron Golden, Pilib O'Broin, David A Sinclair, Michael S Bonkowski, Alexander J Coleville, Danielle Powell, Sharon Kim, Ruin Moaddel, Daniel Stein, Kehao Zhang, Meredith Hawkins, Jill P Crandall
Background: Resveratrol, a plant-derived polyphenol, has been reported to improve glucose metabolism and vascular function and to extend life span in animal models, but studies in humans have been inconclusive. Methods: In a randomized, double-blind crossover study, we treated older glucose-intolerant adults (n = 30) with resveratrol (2-3 g/daily) or placebo, each for 6 weeks. A standard mixed-meal test was used to assess insulin sensitivity (Matsuda index) and secretion (C-peptide deconvolution) and vascular function by reactive hyperemia peripheral arterial tonometry...
March 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28327146/association-between-obstructive-sleep-apnea-severity-and-endothelial-dysfunction-in-patients-with-type-2-diabetes
#2
Vanessa Bironneau, François Goupil, Pierre Henri Ducluzeau, Marc Le Vaillant, Pierre Abraham, Samir Henni, Séverine Dubois, Audrey Paris, Pascaline Priou, Nicole Meslier, Claire Sanguin, Wojciech Trzépizur, Ramaroson Andriantsitohaina, Maria Carmen Martinez, Frédéric Gagnadoux
BACKGROUND: Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D, the impact of OSA severity on endothelial function has not been clearly elucidated. The aim of this cross-sectional study was to determine whether increasing OSA severity is associated with poorer endothelial function in patients with T2D. METHODS: 140 patients with T2D and no overt CV disease underwent polysomnography, peripheral arterial tonometry, clinic blood pressure (BP) measurement, biological assessment for CV risk factors, daytime sleepiness and health related quality of life (HRQL) questionnaires...
March 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28273891/effects-of-long-term-magnesium-supplementation-on-endothelial-function-and-cardiometabolic-risk-markers-a-randomized-controlled-trial-in-overweight-obese-adults
#3
Peter J Joris, Jogchum Plat, Stephan J L Bakker, Ronald P Mensink
Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268419/arterial-pressure-beat-to-beat-characterization-during-post-occlusive-reactive-hyperemia
#4
L J Cymberknop, C R Arbeitman, M R Alfonso, I Farro, R L Armentano
INTRODUCTION: In recent years, peripheral arterial tonometry (PAT, a non-invasive and reproducible technique) has gained considerable interest. In this sense, arterial capacity to react to vasoactive stimulus (induced by reactive hyperemia) is known as vascular reactivity (VR). OBJECTIVE: Post ischemic beat to beat VR characterization was performed based on PAT measurements. METHODS: Systolic Blood Pressure (SBP) and Augmentation index (AIx) variations were modeled, as a response to flow stimulus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28228970/comparison-of-endothelial-function-improvement-estimated-with-reactive-hyperemia-index-between-ramipril-and-telmisartan-in-hypertensive-patients
#5
You-Jeong Ki, Jae-Bin Seo, Hack-Lyoung Kim, Woo-Hyun Lim, Hye Yeon Seo, Jin Yong Lee, Woo-Young Chung
BACKGROUND: Endothelium has a function to regulate vascular tone by releasing mediators either vasodilating or vasoconstricting blood vessels. Endothelial dysfunction can be measured conveniently by Reactive Hyperemia Index (RHI) with a peripheral arterial tonometry. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II (AT II) receptor blockers (ARBs) are considered to have beneficial effects on endothelium through inhibition of AT II. This study was performed to compare the effect of ACEIs or ARBs on endothelial function estimated by RHI in hypertensive patients...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28226589/arterial-pressure-beat-to-beat-characterization-during-post-occlusive-reactive-hyperemia
#6
L J Cymberknop, C R Arbeitman, M R Alfonso, I Farro, R L Armentano, L J Cymberknop, C R Arbeitman, M R Alfonso, I Farro, R L Armentano, R L Armentano, M R Alfonso, I Farro, L J Cymberknop, C R Arbeitman
INTRODUCTION: In recent years, peripheral arterial tonometry (PAT, a non-invasive and reproducible technique) has gained considerable interest. In this sense, arterial capacity to react to vasoactive stimulus (induced by reactive hyperemia) is known as vascular reactivity (VR). OBJECTIVE: Post ischemic beat to beat VR characterization was performed based on PAT measurements. METHODS: Systolic Blood Pressure (SBP) and Augmentation index (AIx) variations were modeled, as a response to flow stimulus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#7
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28128967/impact-of-mandibular-advancement-therapy-on-endothelial-function-in-severe-obstructive-sleep-apnea
#8
Frédéric Gagnadoux, Jean-Louis Pépin, Bruno Vielle, Vanessa Bironneau, Frédérique Chouet-Girard, Sandrine Launois, Nicole Meslier, Jean-Claude Meurice, Xuan-Lan Nguyen, Audrey Paris, Pascaline Priou, Renaud Tamisier, Wojciech Trzepizur, François Goupil, Bernard Fleury
RATIONALE: Endothelial dysfunction, a major predictor of late cardiovascular events, is linked to the severity of obstructive sleep apnea (OSA). OBJECTIVES: To determine whether treatment with mandibular advancement device, the main alternative to continuous positive airway pressure, improves endothelial function in patients with severe OSA. METHODS: In this trial, we randomized patients with severe OSA and no overt cardiovascular disease to receive 2 months of treatment with either effective mandibular advancement device or a sham device...
January 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28110894/endothelial-function-after-st-elevation-myocardial-infarction-in-patients-with-high-levels-of-high-sensitivity-crp-and-lp-pla2-a-substudy-of-the-response-randomized-trial
#9
Jasveen J Kandhai-Ragunath, Bjorn de Wagenaar, Cees Doelman, Jan van Es, Harald T Jørstad, Ron J G Peters, Carine J M Doggen, Clemens von Birgelen
BACKGROUND: The combination of high levels of high-sensitive C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase-A2 (Lp-PLA2) was recently shown to correlate with increased cardiovascular risk. Endothelial dysfunction is also known to be a risk factor for cardiovascular events. AIM: To test among patients with previous ST-elevation myocardial infarction (STEMI) the hypothesis that high levels of both hs-CRP and Lp-PLA2 may be associated with impaired endothelium-dependent vasodilatation...
January 2, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28099636/use-of-reactive-hyperemia-peripheral-arterial-tonometry-and-circulating-biological-markers-to-predict-outcomes-in-sepsis
#10
Vandack Nobre, Thiago Bragança Ataíde, Luisa Caldeira Brant, Clara Rodrigues Oliveira, Lucas Vieira Rodrigues, Antonio Luiz Pinho Ribeiro, Fernanda Barbosa Lopes, Ivan Euclides Saraiva, Marcus Vinícius Andrade
Objective: To evaluate the usefulness and prognostic value of reactive hyperemia - peripheral arterial tonometry in patients with sepsis. Moreover, we investigated the association of reactive hyperemia - peripheral arterial tonometry results with serum levels of certain inflammatory molecules. Methods: Prospective study, conducted in an 18-bed mixed intensive care unit for adults. The exclusion criteria included severe immunosuppression or antibiotic therapy initiated more than 48 hours before assessment...
October 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28078212/improvement-of-endothelial-function-following-initiation-of-testosterone-replacement-therapy
#11
Daniel A Shoskes, Barbara Tucky, Allan S Polackwich
BACKGROUND: Isolated recent studies have suggested an increased risk of heart attack as early as 3 months following testosterone replacement therapy (TRT). Such a rapid risk increase would likely require rapid deterioration of arterial endothelial function. Our goal was to assess arterial endothelial function in hypogonadal men prior to and at least 3 months after initiation of TRT. METHODS: Adult men were consented if they had symptoms of hypogonadism, a total testosterone <350 ng/dL, and planned to begin TRT...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28056981/arterial-stiffness-endothelial-and-cognitive-function-in-subjects-with-type-2-diabetes-in-accordance-with-absence-or-presence-of-diabetic-foot-syndrome
#12
Antonino Tuttolomondo, Alessandra Casuccio, Giovanni Guercio, Carlo Maida, Alessandro Del Cuore, Domenico Di Raimondo, Irene Simonetta, Danilo Di Bona, Rosaria Pecoraro, Vittoriano Della Corte, Eliana Gulotta, Gaspare Gulotta, Antonio Pinto
BACKGROUND: Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic foot is associated with arterial stiffness and endothelial function impairment. METHODS: We studied 50 subjects with type 2 diabetes mellitus and diabetic foot syndrome (DFS) compared to 50 diabetic subjects without diabetic foot, and 53 patients without diabetes mellitus, by means of the mini mental state examination (MMSE) administered to evaluate cognitive performance...
January 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28040274/night-time-blood-pressure-variability-negatively-correlated-with-reactive-hyperemia-index
#13
Yuichi Saito, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi
No abstract text is available yet for this article.
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28036158/premature-atherosclerosis-in-systemic-sclerosis-patients-its-relation-to-disease-parameters-and-to-traditional-risk-factors
#14
Manal M Sedky Abdou, Soha M El Desouky, Khaled M Helmy El Kaffas, Abeer M Ahmed Hassan
AIM: To detect premature atherosclerosis in systemic sclerosis (SSc) patients and its relation to disease parameters and traditional risk factors. METHOD: This study included 40 SSc patients and 40 healthy age and sex matched controls. All patients were subjected to full history taking, clinical examination, relevant laboratory and radiological investigations. Doppler ultrasonography (US) of the common carotid was performed to measure intima-media thickness (ccIMT) and Doppler US of the brachial artery was performed to measure flow mediated dilatation (FMD)...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28032371/tadalafil-for-male-lower-urinary-tract-symptoms-improves-endothelial-function
#15
Kazuhiko Fukumoto, Atsushi Nagai, Ryoei Hara, Tomohiro Fujii, Yoshiyuki Miyaji
OBJECTIVES: To investigate the effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia. METHODS: Tadalafil 5 mg was given to 20 patients with prostatic hyperplasia for whom an α1-blocker was ineffective. Voiding symptoms and vascular endothelial function were investigated before and after 4 and 12 weeks of administration, using commercial tests for vascular function and vascular endothelial function. RESULTS: The participants had a median age of 65 years, a mean body mass index of 24...
December 29, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28004456/maternal-endothelial-function-and-vascular-stiffness-after-hellp-syndrome-a-case-control-study
#16
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Federico Prefumo, Adriana Valcamonico, Marco Metra, Tiziana Frusca
OBJECTIVES: To assess endothelial function and arterial stiffness in women with a previous pregnancy complicated by haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and compare them with women with a previous preeclampsia (PE) without HELLP and controls with uncomplicated pregnancies. METHODS: Women who have had a singleton pregnancy complicated by PE with (n = 49) or without (n = 60) HELLP syndrome and controls (n = 60) underwent peripheral arterial tonometry (EndoPAT method) and pulse wave velocity (PWV) assessment at 6 months-4 years after delivery...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28001011/deterioration-of-endothelial-function-of-micro-and-macrocirculation-in-patients-with-diabetes-type-1-and-2
#17
Hana Besic, Luka Jeraj, Ana Spirkoska, Mateja K Jezovnik, Pavel Poredos
BACKGROUND: Vascular complications are an important cause of morbidity in patients with diabetes mellitus (DM). Endothelial dysfunction is an early marker of atherosclerosis and has already been shown in macrocirculation of diabetic patients, however, data on endothelial function of microcirculation is scarce. Our aim was to evaluate endothelial function in macro- and microcirculation and their interrelationship in patients with type 1 and 2 DM. METHODS: The study included 30 patients with type 1 DM, 30 patients with type 2 DM and 25 healthy controls...
December 20, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27993753/reactive-myocardial-hyperemia-for-functional-assessment-of-coronary-stenosis-severity
#18
Michael Stoller, Christian Seiler
AIM: To compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement as induced by systemic adenosine and by regional reactive myocardial hyperemia. METHODS AND RESULTS: The primary study endpoints were coronary pressure-derived FFR values in response to intravenous adenosine infusion (140µg/min/kg) and to a 1-minute proximal coronary artery balloon occlusion (reactive hyperemia) for the same stenosis of interest. The secondary study endpoint was coronary collateral flow index (CFI) during the same occlusion...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27871219/relationship-between-endothelial-function-of-micro-and-macrocirculation-in-patients-with-peripheral-arterial-disease
#19
Pavel Poredoš, Hana Bešič, Luka Jeraj
BACKGROUND: In the pathogenesis of peripheral arterial occlusive disease (PAD), different risk factors of atherosclerosis are involved which stimulate the development of the functional and morphological deterioration of vessel walls in macro- and microcirculation. The endothelial dysfunction (ED) of macrovessels has been proven, however, data on ED in microcirculation are sparse. Therefore, we have studied the relationship between micro- and macrocirculation in PAD patients. PATIENTS AND METHODS: The study included 85 participants: 30 patients had PAD without diabetes mellitus, 30 patients had PAD and diabetes mellitus type 2, and 25 were healthy controls...
November 24, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27861629/the-relationship-between-endothelial-dysfunction-and-endothelial-cell-markers-in-peripheral-arterial-disease
#20
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
INTRODUCTION: The endothelial function plays key roles in both promoting and protecting against atherosclerotic disease. Several methods, including peripheral arterial tonometry (PAT), have been reported to be useful for investigating endothelial dysfunction. Furthermore, the level of thrombomodulin (TM) is assumed to reflect the endothelial dysfunction. In the present study, we investigated endothelial dysfunction in patients with peripheral arterial disease (PAD) by measuring their TM levels, and evaluated the correlation between TM and various parameters...
2016: PloS One
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