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reactive hyperemia index

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https://www.readbyqxmd.com/read/29330660/theobromine-consumption-does-not-improve-fasting-and-postprandial-vascular-function-in-overweight-and-obese-subjects
#1
Lotte Smolders, Ronald P Mensink, Jose J van den Driessche, Peter J Joris, Jogchum Plat
BACKGOUND: Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE: To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. DESIGN: In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29288158/interrelationships-among-flow-mediated-vasodilation-nitroglycerine-induced-vasodilation-baseline-brachial-artery-diameter-hyperemic-shear-stress-and-cardiovascular-risk-factors
#2
Tatsuya Maruhashi, Yumiko Iwamoto, Masato Kajikawa, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Eisuke Hida, Yukihito Higashi
BACKGROUND: Flow-mediated vasodilation (FMD) of the brachial artery has been used for the assessment of endothelial function. Considering the mechanism underlying the vasodilatory response of the brachial artery to reactive hyperemia, hyperemic shear stress (HSS), a stimulus for FMD; nitroglycerine-induced vasodilation (NID), an index of endothelium-independent vasodilation; and baseline brachial artery diameter (BAD) are also involved in vasodilatory response. The purpose of this study was to investigate the interrelationships among FMD, HSS, NID, baseline BAD, and cardiovascular risk factors...
December 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29240273/endothelial-dysfunction-may-promote-keloid-growth
#3
Chikage Noishiki, Gen Takagi, Yoshiaki Kubota, Rei Ogawa
Keloid is a cutaneous fibroproliferative disorder. It results from impaired wound healing that generates persistent inflammation and extensive deposition of collagen fibers in the wound/scar. Keloids tend to be worse in hypertensive patients. The present prospective cross-sectional study assessed whether endothelial dysfunction, which occurs in hypertension, associates with keloid formation and progression. This study included randomly-selected patients with keloids who were assessed for surgical keloid treatment in 2013-2014...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29209775/effect-of-aggressive-lipid-lowering-treatment-with-rosuvastatin-on-vascular-endothelium-function-evaluation-of-vascular-endothelium-function-earth-study
#4
Tadateru Takayama, Takafumi Hiro, Shunichi Yoda, Daisuke Fukamachi, Hironori Haruta, Takaaki Kogo, Takashi Mineki, Hironobu Murata, Toru Oshima, Atsushi Hirayama
Vascular endothelial dysfunction plays an important role in the process of atherosclerosis up to the final stage of plaque rupture. Vascular endothelial dysfunction is reversible, and can be recovered by medications and life-style changes. Improvement in endothelial function may reduce cardiovascular events and improve long-term prognosis. A total of 50 patients with stable angina and dyslipidemia were enrolled, including patients who had not received prior treatment with statins and had serum LDL-C levels ≥ 100 mg/dL, and patients who had previously received statin treatment...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29203966/microvascular-endothelial-function-in-japanese-early-adolescents
#5
Yutaka Odanaka, Kimitaka Takitani, Hiroshi Katayama, Hiroshi Fujiwara, Kanta Kishi, Noriyasu Ozaki, Atsuko Ashida, Ryuzo Takaya, Hiroshi Tamai
Endothelial dysfunction is the early predictive factor for the development of atherosclerosis and future cardiovascular diseases in adulthood. The prevalence of endothelial dysfunction in children and early adolescents is increasing worldwide. Peripheral arterial tonometry is a noninvasive technique for assessing peripheral microvascular function and is used as a validated marker of endothelial function. We assessed anthropometric parameters, blood pressure, arterial stiffness, and peripheral endothelial function in 157 Japanese early adolescents (75 boys and 82 girls)...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29203235/sensibility-and-specificity-of-laser-speckle-contrast-imaging-according-to-endo-pat-index-in-type-1-diabetes
#6
Alessandra S de M Matheus, Maria de Fátima Bevilacqua da Matta, Eliete Leão Silva Clemente, Maria de Lourdes Guimarães Rodrigues, Débora Cristina Torres Valença, Marília B Gomes
OBJECTIVES: To find out an normality value for microvascular response (physiological and pharmacological) assessed through laser speckle contrast imaging (LSCI) based on Endo-PAT, which identifies the ones with Endothelial Dysfunction (ED) in patients with Type 1 Diabetes (T1D). METHODS: Patients with T1D, aged ≥12years underwent a clinical-epidemiological questionnaire. Fasting blood samples were obtained (lipid profile, glycemic control and levels of C-reactive protein)...
December 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29193492/perfusion-measures-for-symptom-severity-and-differential-outcome-of-revascularization-in-limb-ischemia-preliminary-results-with-arterial-spin-labeling-reactive-hyperemia
#7
Hou-Jen Chen, Trisha L Roy, Graham A Wright
BACKGROUND: Previously, a theoretical model based on microvascular physiology was established to facilitate the interpretation of calf perfusion dynamics recorded by arterial spin labeling (ASL). PURPOSE: To investigate the clinical relevance of novel perfusion indices by comparing them to the symptoms, response to revascularization, and short-term functional outcome in patients with peripheral arterial disease (PAD). STUDY TYPE: Prospective cohort study...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29170641/endothelial-function-in-healthy-young-individuals-is-associated-with-dietary-consumption-of-saturated-fat
#8
Elisabeth A Lambert, Sarah Phillips, Regina Belski, Ainura Tursunalieva, Nina Eikelis, Carolina I Sari, John B Dixon, Nora Straznicky, Mariee Grima, Geoffrey A Head, Markus Schlaich, Gavin W Lambert
Background: A diet rich in fat, in particular saturated fat (SF), may be linked to cardiovascular disease development, possibly due to a detrimental effect of fat on endothelial function (EF). Objective: We aimed to determine whether the habitual SF intake [as a ratio to total fat (the sum of saturated, polyunsaturated, and monounsaturated fat)] might influence endothelial function in young, overweight but otherwise healthy adults. Design: Sixty-nine young adults (49 males, mean age: 23 ± 1 years, mean BMI: 29...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29167121/flow-mediated-dilation-stimulated-by-sustained-increases-in-shear-stress-a-useful-tool-for-assessing-endothelial-function-in-humans
#9
Joshua C Tremblay, Kyra Ellen Pyke
Investigations of human conduit artery endothelial function via flow-mediated vasodilation (FMD) have largely been restricted to the reactive hyperemia (RH) technique, wherein a transient increase in shear stress following the release of limb occlusion stimulates upstream conduit artery vasodilation (RH-FMD). FMD can also be assessed in response to sustained increases in shear stress (sustained stimulus (SS)-FMD), most often created with limb heating or exercise. Exercise in particular creates a physiologically-relevant stimulus because shear stress increases, and FMD occurs, during typical day-to-day activity...
November 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29121934/effect-of-rosuvastatin-on-fasting-and-postprandial-endothelial-biomarker-levels-and-microvascular-reactivity-in-patients-with-type-2-diabetes-and-dyslipidemia-a-preliminary-report
#10
Kyoung Min Kim, Kyong Yeun Jung, Han Mi Yun, Seo Young Lee, Tae Jung Oh, Hak Chul Jang, Soo Lim
BACKGROUND: The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular reactivity. METHOD: We enrolled 20 dyslipidemic patients with type 2 diabetes and 20 age- and body mass index (BMI)-matched healthy controls. Rosuvastatin (20 mg/day) was given to the patient group for 12 weeks...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29106772/effects-of-aerobic-interval-training-on-arterial-stiffness-and-microvascular-function-in-patients-with-metabolic-syndrome
#11
Ricardo Mora-Rodriguez, Miguel Ramirez-Jimenez, Valentin E Fernandez-Elias, Maria V Guio de Prada, Felix Morales-Palomo, Jesus G Pallares, Rachael K Nelson, Juan F Ortega
The authors determined the effect of high-intensity aerobic interval training on arterial stiffness and microvascular dysfunction in patients with metabolic syndrome with hypertension. Applanation tonometry was used to measure arterial stiffness and laser Doppler flowmetry to assess microvascular dysfunction before and after 6 months of stationary cycling (training group; n = 23) in comparison to a group that remained sedentary (control group; n = 23). While no variable improved in controls, hypertension fell from 79% (59%-91%) to 41% (24%-61%) in the training group, resulting in lower systolic and diastolic pressures than controls (-12 ± 3 and -6 ± 2 mm Hg, P < ...
November 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29103858/mental-stress-peripheral-vascular-reactivity-is-elevated-in-women-with-coronary-vascular-dysfunction-results-from-the-nhlbi-sponsored-cardiac-autonomic-nervous-system-cans-study
#12
Puja K Mehta, Melody Hermel, Michael D Nelson, Galen Cook-Wiens, Elizabeth A Martin, Ayman A Alkhoder, Janet Wei, Margo Minissian, Chrisandra L Shufelt, Sailaja Marpuri, David Hermel, Amit Shah, Michael R Irwin, David S Krantz, Amir Lerman, C Noel Bairey Merz
BACKGROUND: Women with chest pain, ischemia, and no obstructive coronary artery disease often have coronary vascular dysfunction (CVaD). Peripheral vascular reactivity to mental stress may contribute mechanistic understanding of stress-induced ischemia in women with CVaD. METHODS: 62 women (41 CVaD and 21 controls) underwent mental stress testing (MST) with anger recall, mental arithmetic, and forehead cold pressor (COP) challenge. Emotional arousal was measured (Likert scale)...
October 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#13
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29063654/improvements-in-peripheral-vascular-function-with-vitamin-d-treatment-in-deficient-adolescents-with-type-1-diabetes
#14
Livia Deda, Yonatan Yeshahayu, Shama Sud, Meaghan Cuerden, David Zi Cherney, Etienne B Sochett, Farid H Mahmud
BACKGROUND: Vitamin D (VitD) deficiency is prevalent in adolescents with type 1 diabetes (T1D) and is associated with diabetes-related vascular complications in adulthood. The objective of this clinical trial was to assess VitD treatment on endothelial function (EF) and markers of renal inflammation, in this patient group. METHODS: Adolescents with T1D with suboptimal levels of VitD (<37.5 nmol/L) were treated for 12 to 24 weeks with a VitD analog (VitD3 ) at doses of 1000 or 2000 IU daily...
October 23, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29044805/the-relationship-between-forearm-skin-speed-resolved-perfusion-and-oxygen-saturation-and-finger-arterial-pulsation-amplitudes-as-indirect-measures-of-endothelial-function
#15
Sara Bergstrand, Maria-Aurora Morales, Giuseppe Coppini, Marcus Larsson, Tomas Strömberg
OBJECTIVE: Endothelial function is important for regulating peripheral blood flow to meet varying metabolic demands and can be measured indirectly during vascular provocations. In this study, we compared the peripheral arterial tonometry finger response (EndoPAT) after a 5 min arterial occlusion to that from forearm skin comprehensive microcirculation analysis (Enhanced Perfusion and Oxygen Saturation, EPOS). METHOD: Measurements in 16 subjects with varying cardiovascular risk factors were done concurrently with both methods during arterial occlusion, while forearm skin was also evaluated during local heating RESULTS: Peak values for EPOS skin conventional perfusion and speed resolved total perfusion after the release of the occlusion, were significantly correlated to the EndoPAT reactive hyperemia index (RHI; ρ=0...
October 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29033166/early-peripheral-endothelial-dysfunction-predicts-myocardial-infarct-extension-and-microvascular-obstruction-in-patients-with-st-elevation-myocardial-infarction
#16
Sérgio Bravo Baptista, Mariana Faustino, Luís Brizida, José Loureiro, João Augusto, João Abecasis, Célia Monteiro, Paulo Leal, Maura Nédio, Pedro Farto E Abreu, Victor Gil, Carlos Morais
INTRODUCTION AND OBJECTIVES: The role of endothelial dysfunction (ED) in patients with ST-elevation myocardial infarction (STEMI) is poorly understood. Peripheral arterial tonometry (PAT) allows non-invasive evaluation of ED, but has never been used for this purpose early after primary percutaneous coronary intervention (P-PCI). Our purpose was to analyze the relation between ED assessed by PAT and both the presence of microvascular obstruction (MVO) and infarct extension in STEMI patients...
October 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29019364/a-serving-of-blueberry-v-corymbosum-acutely-improves-peripheral-arterial-dysfunction-in-young-smokers-and-non-smokers-two-randomized-controlled-crossover-pilot-studies
#17
Cristian Del Bo', Valeria Deon, Jonica Campolo, Claudia Lanti, Marina Parolini, Marisa Porrini, Dorothy Klimis-Zacas, Patrizia Riso
Several studies have documented the important role of polyphenol-rich foods in the modulation of vascular remodelling and function. This study aimed to evaluate the capacity of a single portion of blueberry (V. corymbosum) to acutely improve peripheral arterial dysfunction in a group of young volunteers. Twenty-four healthy males (12 non-smokers and 12 smokers) were recruited for two different randomized, controlled, crossover pilot acute studies. In the first study, non-smokers were exposed to a control treatment (C; 300 mL of water with sugar) and a blueberry treatment (BB; 300 g of blueberry)...
October 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28942095/changes-in-truncal-obesity-and-fat-distribution-predict-arterial-health
#18
Frank E Corrigan, Heval Mohamed Kelli, Devinder S Dhindsa, Robert E Heinl, Ibhar Al Mheid, Muhammad Hammadah, Salim S Hayek, Salman Sher, Danny J Eapen, Greg S Martin, Arshed A Quyyumi
BACKGROUND: Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function. OBJECTIVE: We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function. METHODS: We recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year...
September 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28912211/body-mass-index-is-associated-with-microvascular-endothelial-dysfunction-in-patients-with-treated-metabolic-risk-factors-and-suspected-coronary-artery-disease
#19
Dirk J van der Heijden, Maarten A H van Leeuwen, Gladys N Janssens, Mattie J Lenzen, Peter M van de Ven, Etto C Eringa, Niels van Royen
BACKGROUND: Obesity is key feature of the metabolic syndrome and is associated with high cardiovascular morbidity and mortality. Obesity is associated with macrovascular endothelial dysfunction, a determinant of outcome in patients with coronary artery disease. Here, we compared the influence of obesity on microvascular endothelial function to that of established cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolemia, and smoking in patients with suspected coronary artery disease...
September 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28893762/sleep-disordered-breathing-in-acute-ischemic-stroke-a-mechanistic-link-to-peripheral-endothelial-dysfunction
#20
Nadja Scherbakov, Anja Sandek, Nicole Ebner, Miroslava Valentova, Alexander Heinrich Nave, Ewa A Jankowska, Jörg C Schefold, Stephan von Haehling, Stefan D Anker, Ingo Fietze, Jochen B Fiebach, Karl Georg Haeusler, Wolfram Doehner
BACKGROUND: Sleep-disordered breathing (SDB) after acute ischemic stroke is frequent and may be linked to stroke-induced autonomic imbalance. In the present study, the interaction between SDB and peripheral endothelial dysfunction (ED) was investigated in patients with acute ischemic stroke and at 1-year follow-up. METHODS AND RESULTS: SDB was assessed by transthoracic impedance records in 101 patients with acute ischemic stroke (mean age, 69 years; 61% men; median National Institutes of Health Stroke Scale, 4) while being on the stroke unit...
September 11, 2017: Journal of the American Heart Association
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