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https://www.readbyqxmd.com/read/29121934/effect-of-rosuvastatin-on-fasting-and-postprandial-endothelial-biomarker-levels-and-microvascular-reactivity-in-patients-with-type-2-diabetes-and-dyslipidemia-a-preliminary-report
#1
Kyoung Min Kim, Kyong Yeun Jung, Han Mi Yun, Seo Young Lee, Tae Jung Oh, Hak Chul Jang, Soo Lim
BACKGROUND: The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular reactivity. METHOD: We enrolled 20 dyslipidemic patients with type 2 diabetes and 20 age- and body mass index (BMI)-matched healthy controls. Rosuvastatin (20 mg/day) was given to the patient group for 12 weeks...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29106772/effects-of-aerobic-interval-training-on-arterial-stiffness-and-microvascular-function-in-patients-with-metabolic-syndrome
#2
Ricardo Mora-Rodriguez, Miguel Ramirez-Jimenez, Valentin E Fernandez-Elias, Maria V Guio de Prada, Felix Morales-Palomo, Jesus G Pallares, Rachael K Nelson, Juan F Ortega
The authors determined the effect of high-intensity aerobic interval training on arterial stiffness and microvascular dysfunction in patients with metabolic syndrome with hypertension. Applanation tonometry was used to measure arterial stiffness and laser Doppler flowmetry to assess microvascular dysfunction before and after 6 months of stationary cycling (training group; n = 23) in comparison to a group that remained sedentary (control group; n = 23). While no variable improved in controls, hypertension fell from 79% (59%-91%) to 41% (24%-61%) in the training group, resulting in lower systolic and diastolic pressures than controls (-12 ± 3 and -6 ± 2 mm Hg, P < ...
November 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29103858/mental-stress-peripheral-vascular-reactivity-is-elevated-in-women-with-coronary-vascular-dysfunction-results-from-the-nhlbi-sponsored-cardiac-autonomic-nervous-system-cans-study
#3
Puja K Mehta, Melody Hermel, Michael D Nelson, Galen Cook-Wiens, Elizabeth A Martin, Ayman A Alkhoder, Janet Wei, Margo Minissian, Chrisandra L Shufelt, Sailaja Marpuri, David Hermel, Amit Shah, Michael R Irwin, David S Krantz, Amir Lerman, C Noel Bairey Merz
BACKGROUND: Women with chest pain, ischemia, and no obstructive coronary artery disease often have coronary vascular dysfunction (CVaD). Peripheral vascular reactivity to mental stress may contribute mechanistic understanding of stress-induced ischemia in women with CVaD. METHODS: 62 women (41 CVaD and 21 controls) underwent mental stress testing (MST) with anger recall, mental arithmetic, and forehead cold pressor (COP) challenge. Emotional arousal was measured (Likert scale)...
October 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#4
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29063654/improvements-in-peripheral-vascular-function-with-vitamin-d-treatment-in-deficient-adolescents-with-type-1-diabetes
#5
Livia Deda, Yonatan Yeshahayu, Shama Sud, Meaghan Cuerden, David Zi Cherney, Etienne B Sochett, Farid H Mahmud
BACKGROUND: Vitamin D (VitD) deficiency is prevalent in adolescents with type 1 diabetes (T1D) and is associated with diabetes-related vascular complications in adulthood. The objective of this clinical trial was to assess VitD treatment on endothelial function (EF) and markers of renal inflammation, in this patient group. METHODS: Adolescents with T1D with suboptimal levels of VitD (<37.5 nmol/L) were treated for 12 to 24 weeks with a VitD analog (VitD3 ) at doses of 1000 or 2000 IU daily...
October 23, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29044805/the-relationship-between-forearm-skin-speed-resolved-perfusion-and-oxygen-saturation-and-finger-arterial-pulsation-amplitudes-as-indirect-measures-of-endothelial-function
#6
Sara Bergstrand, Maria-Aurora Morales, Giuseppe Coppini, Marcus Larsson, Tomas Strömberg
OBJECTIVE: Endothelial function is important for regulating peripheral blood flow to meet varying metabolic demands and can be measured indirectly during vascular provocations. In this study, we compared the peripheral arterial tonometry finger response (EndoPAT) after a 5 min arterial occlusion to that from forearm skin comprehensive microcirculation analysis (Enhanced Perfusion and Oxygen Saturation, EPOS). METHOD: Measurements in 16 subjects with varying cardiovascular risk factors were done concurrently with both methods during arterial occlusion, while forearm skin was also evaluated during local heating RESULTS: Peak values for EPOS skin conventional perfusion and speed resolved total perfusion after the release of the occlusion, were significantly correlated to the EndoPAT reactive hyperemia index (RHI; ρ=0...
October 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29033166/early-peripheral-endothelial-dysfunction-predicts-myocardial-infarct-extension-and-microvascular-obstruction-in-patients-with-st-elevation-myocardial-infarction
#7
Sérgio Bravo Baptista, Mariana Faustino, Luís Brizida, José Loureiro, João Augusto, João Abecasis, Célia Monteiro, Paulo Leal, Maura Nédio, Pedro Farto E Abreu, Victor Gil, Carlos Morais
INTRODUCTION AND OBJECTIVES: The role of endothelial dysfunction (ED) in patients with ST-elevation myocardial infarction (STEMI) is poorly understood. Peripheral arterial tonometry (PAT) allows non-invasive evaluation of ED, but has never been used for this purpose early after primary percutaneous coronary intervention (P-PCI). Our purpose was to analyze the relation between ED assessed by PAT and both the presence of microvascular obstruction (MVO) and infarct extension in STEMI patients...
October 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29019364/a-serving-of-blueberry-v-corymbosum-acutely-improves-peripheral-arterial-dysfunction-in-young-smokers-and-non-smokers-two-randomized-controlled-crossover-pilot-studies
#8
Cristian Del Bo', Valeria Deon, Jonica Campolo, Claudia Lanti, Marina Parolini, Marisa Porrini, Dorothy Klimis-Zacas, Patrizia Riso
Several studies have documented the important role of polyphenol-rich foods in the modulation of vascular remodelling and function. This study aimed to evaluate the capacity of a single portion of blueberry (V. corymbosum) to acutely improve peripheral arterial dysfunction in a group of young volunteers. Twenty-four healthy males (12 non-smokers and 12 smokers) were recruited for two different randomized, controlled, crossover pilot acute studies. In the first study, non-smokers were exposed to a control treatment (C; 300 mL of water with sugar) and a blueberry treatment (BB; 300 g of blueberry)...
October 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28942095/changes-in-truncal-obesity-and-fat-distribution-predict-arterial-health
#9
Frank E Corrigan, Heval Mohamed Kelli, Devinder S Dhindsa, Robert E Heinl, Ibhar Al Mheid, Muhammad Hammadah, Salim S Hayek, Salman Sher, Danny J Eapen, Greg S Martin, Arshed A Quyyumi
BACKGROUND: Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function. OBJECTIVE: We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function. METHODS: We recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year...
September 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28912211/body-mass-index-is-associated-with-microvascular-endothelial-dysfunction-in-patients-with-treated-metabolic-risk-factors-and-suspected-coronary-artery-disease
#10
Dirk J van der Heijden, Maarten A H van Leeuwen, Gladys N Janssens, Mattie J Lenzen, Peter M van de Ven, Etto C Eringa, Niels van Royen
BACKGROUND: Obesity is key feature of the metabolic syndrome and is associated with high cardiovascular morbidity and mortality. Obesity is associated with macrovascular endothelial dysfunction, a determinant of outcome in patients with coronary artery disease. Here, we compared the influence of obesity on microvascular endothelial function to that of established cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolemia, and smoking in patients with suspected coronary artery disease...
September 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28893762/sleep-disordered-breathing-in-acute-ischemic-stroke-a-mechanistic-link-to-peripheral-endothelial-dysfunction
#11
Nadja Scherbakov, Anja Sandek, Nicole Ebner, Miroslava Valentova, Alexander Heinrich Nave, Ewa A Jankowska, Jörg C Schefold, Stephan von Haehling, Stefan D Anker, Ingo Fietze, Jochen B Fiebach, Karl Georg Haeusler, Wolfram Doehner
BACKGROUND: Sleep-disordered breathing (SDB) after acute ischemic stroke is frequent and may be linked to stroke-induced autonomic imbalance. In the present study, the interaction between SDB and peripheral endothelial dysfunction (ED) was investigated in patients with acute ischemic stroke and at 1-year follow-up. METHODS AND RESULTS: SDB was assessed by transthoracic impedance records in 101 patients with acute ischemic stroke (mean age, 69 years; 61% men; median National Institutes of Health Stroke Scale, 4) while being on the stroke unit...
September 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28889234/peripheral-arterial-tonometry-in-pulmonary-vasculitis
#12
A Falkowski, K A Wardyn, K Życińska
Vascular wall inflammation in primary vasculitides results in diminished vessel dilation and finally impaired blood flow, causing multiple organs dysfunction and ultimate damage. In granulomatosis with polyangiitis (GPA), the inflammatory process concerns small and medium sized vessels and its pulmonary location is often predominant. The pivotal role in the development of that pathology plays vascular endothelium. Endothelial vasodilatory function strongly depends on the instant production and release of nitrogen oxide (NO), a potent local factor controlling vascular tonus...
September 10, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28860792/endothelial-dysfunction-in-patients-with-buerger-disease
#13
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28853979/the-effect-of-atorvastatin-on-vascular-function-and-structure-in-young-adult-survivors-of-childhood-cancer-a-randomized-placebo-controlled-pilot-clinical-trial
#14
Kara L Marlatt, Julia Steinberger, Kyle D Rudser, Donald R Dengel, Karim T Sadak, Jill L Lee, Anne H Blaes, Daniel A Duprez, Joanna L Perkins, Julie A Ross, Aaron S Kelly
PURPOSE: Many adult survivors of childhood cancer are at high-risk of developing cardiovascular disease. Cancer therapy may cause damage to the vascular endothelium, thereby initiating atherosclerosis. Atorvastatin has been shown to improve endothelial function independent of reducing cholesterol, as well as reduce/slow arterial stiffness and thickening, yet has never been studied in childhood cancer survivors (CCS). METHODS: Twenty-seven young adult (age 26.8 ± 6...
August 30, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28794106/flow-mediated-dilation-and-peripheral-arterial-tonometry-are-disturbed-in-pre-eclampsia-and-reflect-different-aspects-of-endothelial-function
#15
Dominique Mannaerts, Ellen Faes, Inge Goovaerts, Tibor Stoop, Jerome Cornette, Wilfried Jozef Gyselaers, Marc E A Spaanderman, Emeline M Van Craenenbroeck, Yves Jacquemyn
BACKGROUND: Endothelial function and arterial stiffness are known to be altered in pre-eclamptic pregnancies. Previous studies have shown conflicting results regarding the best technique for assessing vascular function in pregnancy. In this study, we made a comprehensive evaluation of in vivo vascular function (including flow-mediated dilatation (FMD), peripheral arterial tonometry (PAT), and arterial stiffness) in pre-eclamptic patients and compared them to normal pregnancies. In addition, we assessed the relation between vascular function and systemic inflammation...
August 9, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28768922/preoperative-assessment-of-endothelial-function-for-prediction-of-adverse-events-after-cardiovascular-surgery
#16
Yuichi Saito, Hideki Kitahara, Goro Matsumiya, Yoshio Kobayashi
BACKGROUND: Cardiovascular surgery is one of the highest risk procedures in the field of surgery. Preoperative assessment of endothelial function has been reported as useful for predicting postoperative adverse events (AEs). The aim of this study was to investigate the relationship between endothelial function assessed by reactive hyperemia index (RHI) and AEs after cardiovascular surgery.Methods and Results:A prospective observational study of 197 patients who underwent cardiovascular surgery was conducted...
August 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28750006/the-impact-of-repetitive-long-duration-water-immersion-on-vascular-function
#17
Erin E Simmons, Elizabeth R Bergeron, John P Florian
While physiological responses to water immersion (WI) are well-studied, the vascular responses after WI are less understood. Fifteen male subjects performed six-hour resting thermoneutral water immersions (WI) at 1.35 atmospheres absolute for four consecutive days, with follow-up on the fifth day. Measurements included peripheral endothelial function and augmentation index (PAT, peripheral arterial tonometry), beat-to-beat blood pressure (BP, photoplethysmography), heart rate (HR), and plasma volume (PV) calculated from changes in hemoglobin and hematocrit...
2017: PloS One
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#18
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28721151/moderate-dose-atorvastatin-improves-arterial-endothelial-function-in-patients-with-angina-pectoris-and-normal-coronary-angiogram-a-pilot-study
#19
Amela Kabaklić, Zlatko Fras
INTRODUCTION: Endothelial dysfunction could contribute to the pathophysiology of angina pectoris (AP) in patients with normal coronary angiograms. Besides lipid-lowering effects, statins exert pleiotropic effects including improving endothelial function. MATERIAL AND METHODS: Our double-blind study included 58 patients with AP, noninvasively confirmed myocardial ischemia and a normal coronary angiogram. The effect of once-daily 20 mg atorvastatin (A) was compared with placebo (P) for 6 months...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28668398/differences-in-endothelial-dysfunction-induced-by-paroxysmal-and-persistent-atrial-fibrillation-insights-from-restoration-of-sinus-rhythm-by-catheter-ablation
#20
Keisuke Okawa, Toru Miyoshi, Saori Tsukuda, Syouhei Hara, Naoaki Matsuo, Noriyuki Nishibe, Masahiro Sogo, Tomoaki Okada, Kazumasa Nosaka, Kousuke Sakane, Masayuki Doi, Hiroshi Morita, Hiroshi Ito
BACKGROUND: Atrial fibrillation (AF) is associated with endothelial dysfunction. Studies have shown the incidence of cardiovascular events to be greater in patients with persistent AF (PeAF) than paroxysmal AF (PAF). OBJECTIVE: The aim of this study was to investigate whether endothelial dysfunction and the impact of catheter ablation on the endothelial function differs between PAF and PeAF. METHODS: We prospectively measured the endothelial function by reactive hyperemia peripheral arterial tonometry (RH-PAT) in 103 PAF, 75 PeAF, and 51 control patients at baseline, with follow-up in the AF patients at 6 and 12months after the catheter ablation...
October 1, 2017: International Journal of Cardiology
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