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reactive hyperemia index

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https://www.readbyqxmd.com/read/28526381/medium-term-effect-of-sublingual-l-glutathione-supplementation-on-flow-mediated-dilation-in-subjects-with-cardiovascular-risk-factors
#1
Jonica Campolo, Stefano Bernardi, Lorena Cozzi, Silvia Rocchiccioli, Cinzia Dellanoce, Antonella Cecchettini, Annamaria Tonini, Marina Parolini, Benedetta De Chiara, Gianpaolo Micheloni, Gualtiero Pelosi, Claudio Passino, Cristina Giannattasio, Oberdan Parodi
OBJECTIVE: Supplementation of glutathione (GSH) may be a positive strategy to improve the endogenous antioxidant defense required to counteract many acute and chronic diseases. However, the efficacy of GSH treatment seems to be closely related to type of administration, degree of absorption, and increase of its concentrations. The aim of this study was to test a new sublingual formulation of L-GSH, which enters directly the systemic circulation, to assess its efficacy on circulating biochemical markers of hepatic metabolism, lipid profile, and oxidative stress and on peripheral vascular function compared with placebo in patients with cardiovascular risk factors (CVRF)...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28525354/the-relationship-between-insulin-resistance-and-endothelial-dysfunction-in-obese-adolescents
#2
Preneet Cheema Brar, Payal Patel, Stuart Katz
BACKGROUND: Insulin resistance and endothelial dysfunction share a reciprocal relationship that links the metabolic and cardiovascular sequelae of obesity. We characterized the brachial artery reactivity testing (BART) and carotid artery-intima media thickness (CIMT) in adolescents categorized as obese insulin resistant (OIR) and obese not insulin resistant (ONIR). Lipoprotein particle (p) analysis and inflammatory cytokines in OIR and ONIR groups were also analyzed. METHODS: Obese adolescents (n=40; mean body mass index [BMI] 35...
May 18, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28515707/validation-of-repeated-endothelial-function-measurements-using-endopat-in-stroke
#3
Aina S Hansen, Jawad H Butt, Sonja Holm-Yildiz, William Karlsson, Christina Kruuse
BACKGROUND: Decreased endothelial function (EF) may be a prognostic marker for stroke. Measuring pharmacological effects on EF may be of interest in the development of personalized medicine for stroke prevention. In this study, we assessed the reliability of repeated EF measurements using a pulse amplitude tonometry technology in acute stroke patients. Similarly, reliability was tested in healthy subjects devoid of vascular disease to estimate reactivity and reliability in a younger non-stroke population...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#4
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28508133/children-and-adolescents-macrovascular-reactivity-level-and-dynamics-but-not-the-microvascular-response-is-associated-with-body-mass-index-and-arterial-stiffness-levels
#5
Yanina Zócalo, Marco Marotta, Victoria García-Espinosa, Santiago Curcio, Pedro Chiesa, Gustavo Giachetto, Daniel Bia
INTRODUCTION: The existing evidence indicates that primary prevention of atherosclerotic disease should begin in childhood. Detection of children and adolescents at risk for atherosclerosis may allow early intervention to decrease the atherosclerotic process, thereby preventing or delaying cardiovascular disease. Vascular reactivity (VR) is altered even by early atherosclerosis. Obesity is a main cardiovascular risk factor (CVRF) observed in childhood. If childhood obesity associates impaired macro and/or micro VR is controversial...
May 15, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28488836/effects-of-low-load-resistance-exercise-with-blood-flow-restriction-on-intramuscular-hemodynamics-oxygenation-level-and-water-content
#6
Osamu Yanagisawa, Atsuki Fukutani
BACKGROUND: Muscle metabolism during and after low-load blood flow restriction (BFR) exercise should be further investigated to clarify the mechanism by which the exercise leads to muscle hypertrophy, and increases strength and endurance. We aimed to investigate the effects of low-load resistance exercise with BFR on intramuscular hemodynamics, oxygenation level, and water content. METHODS: Seven men performed ankle plantar flexion exercise (120 repetitions, 30% one repetition maximum) using a custom-made device with and without BFR inside a magnetic resonance scanner...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28465609/childhood-body-mass-index-and-endothelial-dysfunction-evaluated-by-peripheral-arterial-tonometry-in-early-midlife
#7
M J A Williams, B J Milne, A Ambler, R Theodore, S Ramrakha, A Caspi, T E Moffitt, R Poulton
BACKGROUND/OBJECTIVES: Endothelial dysfunction predicts mortality but it is unknown whether childhood obesity predicts adult endothelial dysfunction. The aim of this study was to determine whether anthropometric indices of body fat in childhood, adolescence and early midlife are associated with endothelial dysfunction in early midlife. SUBJECTS/METHODS: Participants belonged to a representative birth cohort of 1037 individuals born in Dunedin, New Zealand in 1972 and 1973 and followed to age 38 years, with 95% retention (the Dunedin Multidisciplinary Health and Development Study)...
May 3, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28447271/the-relationship-between-vascular-endothelial-dysfunction-and-treatment-frequency-in-neovascular-age-related-macular-degeneration
#8
Tomoko Ueda-Consolvo, Atsushi Hayashi, Mayumi Ozaki, Tomoko Nakamura, Takaaki Yagou, Shinya Abe
PURPOSE: To assess the correlation between endothelial dysfunction and frequency of antivascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (nAMD). METHODS: We examined 64 consecutive patients with nAMD who were evaluated for endothelial function by use of peripheral arterial tonometry (EndoPAT 2000; Itamar Medical, Caesarea, Israel) at Toyama University Hospital from January 2015. We tallied the number of anti-VEGF treatments between January 2014 and December 2015 and determined the correlation between the number of anti-VEGF injections and endothelial function expressed as the reactive hyperemia index (RHI)...
April 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28446494/effects-of-the-mean-amplitude-of-glycemic-excursions-and-vascular-endothelial-dysfunction-on-cardiovascular-events-in-nondiabetic-patients-with-coronary-artery-disease
#9
Tomonori Akasaka, Daisuke Sueta, Noriaki Tabata, Seiji Takashio, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kunihiko Matsui, Seiji Hokimoto
BACKGROUND: Mean amplitude of glycemic excursion (MAGE) is commonly used to gauge the degree of glucose level fluctuations. MAGE plays a significant role in vascular endothelial dysfunction and cardiovascular events in patients with diabetes mellitus (DM), but its significance is not clear in non-DM patients. Thus, we examined the impact of MAGE and vascular endothelial dysfunction on clinical outcomes in non-DM patients with coronary artery disease. METHODS AND RESULTS: We followed non-DM patients (n=65) for 12 months who underwent percutaneous coronary intervention and assessed the relationship among MAGE, reactive hyperemia index (RHI) measured by reactive hyperemia peripheral arterial tonometry as endothelial function, and cardiovascular events...
April 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28436117/early-introduction-of-oral-paricalcitol-in-renal-transplant-recipients-an-open-label-randomized-study
#10
Hege Kampen Pihlstrøm, Franscesca Gatti, Clara Hammarström, Ivar Anders Eide, Monika Kasprzycka, Junbai Wang, Guttorm Haraldsen, My Hanna Sofia Svensson, Karsten Midtvedt, Geir Mjøen, Dag Olav Dahle, Anders Hartmann, Hallvard Holdaas
In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de-novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-centre, prospective, randomized, open-label trial investigating effects of paricalcitol 2μg/day added to standard care...
April 24, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28412277/the-association-of-endothelial-function-and-tone-by-digital-arterial-tonometry-with-mri-left-ventricular-mass-in-african-americans-the-jackson-heart-study
#11
Avnish Tripathi, Emelia J Benjamin, Solomon K Musani, Naomi M Hamburg, Connie W Tsao, Arti Saraswat, Ramachandran S Vasan, Gary F Mitchell, Ervin R Fox
Peripheral vascular endothelial dysfunction assessed by digital peripheral arterial tonometry (PAT) has been associated with risk for adverse cardiovascular events. We examined the relations of peripheral microvascular dysfunction and left ventricular mass in a community-based cohort of African Americans. We examined participants of the Jackson Heart Study who had PAT and cardiac magnetic resonance imaging evaluations between 2007 and 2013. Consistent with pertinent literature, left ventricular mass index (LVMI) was adjusted for body size by indexing to height(2...
March 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28408073/pre-procedural-peripheral-endothelial-function-is-associated-with-increased-serum-creatinine-following-percutaneous-coronary-procedure-in-stable-patients-with-a-preserved-estimated-glomerular-filtration-rate
#12
Hitoshi Sumida, Yasushi Matsuzawa, Seigo Sugiyama, Koichi Sugamura, Toshimitsu Nozaki, Eiichi Akiyama, Keisuke Ohba, Masaaki Konishi, Junichi Matsubara, Koichiro Fujisue, Hirofumi Maeda, Hirofumi Kurokawa, Satomi Iwashita, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: Worsening renal function, indicated by increased serum creatinine (SCr), is a common complication of percutaneous coronary procedures. Risk factors for increased SCr overlap with coronary risk factors involved in endothelial dysfunction. We hypothesized that endothelial dysfunction, measured using the reactive hyperemia peripheral arterial tonometry index (RHI), can predict periprocedure-increased SCr. METHODS: RHI was assessed before elective coronary procedures in 316 consecutive stable patients with a preserved estimated glomerular filtration rate (eGFR, >60mL/min/1...
April 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28403850/rationale-and-design-of-a-multicenter-placebo-controlled-double-blind-randomized-trial-to-evaluate-the-effect-of-empagliflozin-on-endothelial-function-the-emblem-trial
#13
RANDOMIZED CONTROLLED TRIAL
Atsushi Tanaka, Michio Shimabukuro, Yosuke Okada, Isao Taguchi, Minako Yamaoka-Tojo, Hirofumi Tomiyama, Hiroki Teragawa, Seigo Sugiyama, Hisako Yoshida, Yasunori Sato, Atsushi Kawaguchi, Yumi Ikehara, Noritaka Machii, Tatsuya Maruhashi, Kosuke R Shima, Toshinari Takamura, Yasushi Matsuzawa, Kazuo Kimura, Masashi Sakuma, Jun-Ichi Oyama, Teruo Inoue, Yukihito Higashi, Shinichiro Ueda, Koichi Node
BACKGROUND: Type 2 diabetes mellitus (T2DM) is characterized by systemic metabolic abnormalities and the development of micro- and macrovascular complications, resulting in a shortened life expectancy. A recent cardiovascular (CV) safety trial, the EMPA-REG OUTCOME trial, showed that empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, markedly reduced CV death and all-cause mortality and hospitalization for heart failure in patients with T2DM and established CV disease (CVD)...
April 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28392282/heme-nitrosylated-hemoglobin-and-oxidative-stress-in-women-consuming-combined-contraceptives-clinical-application-of-the-epr-spectroscopy
#14
Irina I Lobysheva, Sandrine van Eeckhoudt, Flavia Dei Zotti, Ahmad Rifahi, Lucie Pothen, Christophe Beauloye, Jean-Luc Balligand
An increased risk of venous thromboembolism was identified in young women consuming combined contraceptive pills (CP) suggesting a disturbance of vascular homeostasis but the impact of CP on endothelial function and redox status of the vasculature was not thoroughly analyzed. We measured the bioavailability of nitric oxide (NO), a main mediator of vascular homeostasis in a cohort of young female subjects (n=114) and compared the results in users or not of CPs containing ethinyl estradiol and synthetic progestogens...
April 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28390289/lenvatinib-an-oral-multi-kinases-inhibitor-associated-hypertension-potential-role-of-vascular-endothelial-dysfunction
#15
Daisuke Sueta, Koichi Suyama, Aiko Sueta, Noriaki Tabata, Takayoshi Yamashita, Mai Tomiguchi, Takashi Takeshita, Mutsuko Yamamoto-Ibusuki, Eiichiro Yamamoto, Yasuhiro Izumiya, Koichi Kaikita, Yutaka Yamamoto, Seiji Hokimoto, Hirotaka Iwase, Kenichi Tsujita
BACKGROUND AND AIMS: Lenvatinib (Lenvima(®)), an oral multi-kinase inhibitor, is effective in the treatment of differentiated thyroid carcinomas (DTCs). A severe adverse effect of lenvatinib is hypertension, thus limiting its use as an anti-cancer treatment. Although the pathogenesis of hypertension is generally assumed to involve microvascular bed reduction and an increase in peripheral vascular resistance due to a decrease in nitrogen oxide (NOx) production after vascular endothelial growth factor (VEGF) inhibition, the effects of hypertension on vascular endothelial function in actual patients remain unclear...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28358388/reactive-hyperemia-index-in-patients-on-maintenance-hemodialysis-cross-sectional-data-from-a-cohort-study
#16
Wenjin Liu, Meijuan Meng, Jianping Chen, Liang Wang, Zhuxing Sun, Xiurong Li, Jianmei Zhou, Chaoqing Gao, Jiajun Zhou, Hong Chu, Wei Fan, Youwei Bai, Junwei Yang
Previous studies suggested that the reactive hyperemia index (RHI) is a promising cardiovascular risk predictor. We aimed to evaluate clinical determinants of RHI and its association with circulating endothelial injury and cardiac markers in hemodialysis patients. Among 368 patients recruited, RHI was evaluated by peripheral arterial tonometry (PAT) on a midweek nondialysis day. Clinical determinants of RHI were explored by multiple stepwise regression analysis and associations between RHI and circulating markers were evaluated by general linear models...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344817/urinary-biomarkers-as-indicator-of-chronic-inflammation-and-endothelial-dysfunction-in-obese-adolescents
#17
Ruchi Singh, Arushi Verma, Salim Aljabari, Tetyana L Vasylyeva
BACKGROUND: Obesity is a pro-inflammatory state that may predispose patients to acute coronary syndrome characterized by chronic low grade inflammation resulting in endothelial dysfunction (ED). The aim of the study was to evaluate urinary biomarkers of inflammation and ED in adolescents with obesity. METHODS: Sixty three subjects were recruited for the study. Twenty healthy adolescents with normal body mass (NW), 14 overweight (OW), 29 obese (OA) subjects were selected...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28329397/resveratrol-improves-vascular-function-and-mitochondrial-number-but-not-glucose-metabolism-in-older-adults
#18
Rena M Pollack, Nir Barzilai, Valentin Anghel, Ameya S Kulkarni, Aaron Golden, Pilib O'Broin, David A Sinclair, Michael S Bonkowski, Alexander J Coleville, Danielle Powell, Sharon Kim, Ruin Moaddel, Daniel Stein, Kehao Zhang, Meredith Hawkins, Jill P Crandall
Background: Resveratrol, a plant-derived polyphenol, has been reported to improve glucose metabolism and vascular function and to extend life span in animal models, but studies in humans have been inconclusive. Methods: In a randomized, double-blind crossover study, we treated older glucose-intolerant adults (n = 30) with resveratrol (2-3 g/daily) or placebo, each for 6 weeks. A standard mixed-meal test was used to assess insulin sensitivity (Matsuda index) and secretion (C-peptide deconvolution) and vascular function by reactive hyperemia peripheral arterial tonometry...
March 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28327146/association-between-obstructive-sleep-apnea-severity-and-endothelial-dysfunction-in-patients-with-type-2-diabetes
#19
Vanessa Bironneau, François Goupil, Pierre Henri Ducluzeau, Marc Le Vaillant, Pierre Abraham, Samir Henni, Séverine Dubois, Audrey Paris, Pascaline Priou, Nicole Meslier, Claire Sanguin, Wojciech Trzépizur, Ramaroson Andriantsitohaina, Maria Carmen Martinez, Frédéric Gagnadoux
BACKGROUND: Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D, the impact of OSA severity on endothelial function has not been clearly elucidated. The aim of this cross-sectional study was to determine whether increasing OSA severity is associated with poorer endothelial function in patients with T2D. METHODS: 140 patients with T2D and no overt CV disease underwent polysomnography, peripheral arterial tonometry, clinic blood pressure (BP) measurement, biological assessment for CV risk factors, daytime sleepiness and health related quality of life (HRQL) questionnaires...
March 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28273891/effects-of-long-term-magnesium-supplementation-on-endothelial-function-and-cardiometabolic-risk-markers-a-randomized-controlled-trial-in-overweight-obese-adults
#20
Peter J Joris, Jogchum Plat, Stephan J L Bakker, Ronald P Mensink
Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules...
December 2017: Scientific Reports
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