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reactive hyperemia index

Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
Pavel Šiarnik, Zuzana Čarnická, Zuzana Krivošíková, Katarína Klobučníková, Ingrid Žitňanová, Branislav Kollár, Marek Sýkora, Peter Turčáni
Hypercholesterolemia represents a risk factor for the development of atherosclerosis. Lipoprotein research has recently been focused on the phenomenon of atherogenic and non-atherogenic lipoproteins. The aim of this study was to explore the association of lipoprotein subfractions with a measure for endothelial function (represented by reactive hyperemia index [RHI]) and arterial stiffness (represented by augmentation index [AI]) in patients with acute ischemic stroke. We enrolled 51 patients with acute ischemic stroke...
October 19, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
Charlotte Iacobaeus, Ellika Andolf, Malin Thorsell, Katarina Bremme, Gun JÖrneskog, Eva Östlund, Thomas Kahan
OBJECTIVE: To examine alterations in maternal vascular structure and function during normal pregnancy. METHODS: We assessed brachial and central blood pressure, pulse wave velocity and augmentation index (by pulse wave analysis and applanation tonometry), common carotid artery structure (by ultrasonography), and endothelial function in the brachial artery (by post-ischemic hyperemia induced flow mediated vasodilation and glyceryl nitrate) and in the forearm skin microcirculation (by laser Doppler perfusion imaging during iontophoretic administration of acetylcholine and sodium nitroprusside) in 52 healthy primiparous women at 14, 24 and 34 weeks of gestation, and nine months post partum...
October 12, 2016: Ultrasound in Obstetrics & Gynecology
Edip Güvenç Çekiç, Özcan Başaran, Nesrin Filiz Başaran, Onur Elmas, Volkan Doğan, Gurbet Özge Mert, Kadir Uğur Mert, Ibrahim Altun, Fatih Akın, Murat Biteker
BACKGROUND AND AIM: Decreased vascular reactivity in atherosclerosis was previously shown. In our study, it was aimed to demonstrate the decreased vascular functions in both microvascular and macrovascular tissues and to estimate any correlation between them. METHODS: Twenty-five control outpatients with no coronary artery disease (CAD) history and 26 outpatients with CAD history were enrolled in the study. Local cutaneous post-occlusive reactive hyperemia (PORH) responses after three minutes of brachial occlusion with a pneumatic cuff were recorded noninvasively by a Perimed Periflux 5010 laser Doppler flow system...
September 28, 2016: Microvascular Research
M J Landram, A C Utter, C Baldari, L Guidetti, S R McAnulty, S R Collier
The purpose of this study was to compare the hemodynamic, arterial stiffness, and blood flow changes following four weeks of either continuous or discontinuous aerobic exercise in adults. Forty-seven subjects between the ages of 18 and 57 were recruited for one month of either continuous aerobic treadmill work for 30 minutes at 70% max heart rate or 3 bouts of 10 minutes of exercise at 70% of max heart rate with two 10 minute break periods in between, totaling 30 minutes of aerobic work. Following exercise, both CON and DIS groups demonstrated a significant improvement in VO2max (CON 35...
September 23, 2016: Journal of Strength and Conditioning Research
Bryan H Goldstein, Elaine M Urbina, Philip R Khoury, Zhiqian Gao, Michelle A Amos, Wayne A Mays, Andrew N Redington, Bradley S Marino
BACKGROUND: Fontan survivors demonstrate diminished vascular function and functional outcomes, but the relationships between these measures have not been established. METHODS AND RESULTS: We performed a cross-sectional study of 60 Fontan survivors (52% male) with a mean age of 13.9±4.1 years and mean Fontan duration of 9.9±4.2 years. Multimodality assessment of endothelial function (reactive hyperemia index and flow-mediated dilation) and arterial stiffness (augmentation index and baseline pulse amplitude) was performed with peripheral arterial tonometry and brachial flow-mediated dilation...
September 24, 2016: Journal of the American Heart Association
Valerio Sanguigni, Melania Manco, Roberto Sorge, Lucio Gnessi, Davide Francomano
OBJECTIVE: The formation of reactive oxygen species (ROS) contributes to the pathogenesis and progression of several diseases. Polyphenols have been shown to be beneficial against ROS. The aim of this study was to evaluate the effects of a natural antioxidant ice cream on oxidative stress, vascular function, and physical performance. METHODS: In this controlled, single-blind, crossover study, 14 healthy individuals were randomized to consume 100 g of either antioxidant ice cream containing dark cocoa powder and hazelnut and green tea extracts or milk chocolate ice cream (control ice cream)...
July 26, 2016: Nutrition
Yaniv Levi, Ayyaz Sultan, Mistre Alemayehu, Sabrina Wall, Shahar Lavi
BACKGROUND: Coronary no-reflow during primary percutaneous coronary intervention (PPCI) is a predictor of poorer cardiovascular outcome. Both endothelial dysfunction and no-reflow involves abnormal vascular function and hemostasis. Our aim was to assess the association between endothelial dysfunction and no reflow during primary PCI. METHODS: Thirty consecutive patients with ST elevation myocardial infarction (STEMI) and normal flow during primary PCI were compared to 19 consecutive patients who had no reflow...
September 3, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Bridget E Barber, Timothy William, Matthew J Grigg, Kim A Piera, Youwei Chen, Hao Wang, J Brice Weinberg, Tsin W Yeo, Nicholas M Anstey
BACKGROUND:  Pathogenesis of severe Plasmodium vivax malaria is poorly understood. Endothelial dysfunction and reduced nitric-oxide (NO) bioavailability characterise severe falciparum malaria, but have not been assessed in severe vivax malaria. METHODS:  In patients with severe (n=9) and non-severe (n=58) vivax malaria, and in healthy controls (HCs, N=79) we measured NO-dependent endothelial function using reactive hyperemia-peripheral arterial tonometry (RH-PAT), and assessed associations with arginine, asymmetric dimethylarginine (ADMA) and haemolysis...
September 13, 2016: Journal of Infectious Diseases
Yasushi Matsuzawa, Mahmoud Suleiman, Raviteja R Guddeti, Taek-Geun Kwon, Kristi H Monahan, Lilach O Lerman, Paul A Friedman, Amir Lerman
BACKGROUND: The mechanisms of atrial fibrillation (AF) are highly divergent. The prevalence of AF increases significantly with age, and underling mechanisms might vary with age. Endothelial dysfunction may be associated with AF and atrial arrhythmia recurrence after catheter ablation. We tested the hypothesis that the impact of endothelial dysfunction on arrhythmia recurrence following catheter ablation is age dependent. METHODS AND RESULTS: This study enrolled 92 participants with AF undergoing catheter ablation...
September 2016: Journal of the American Heart Association
Eiichiro Yamamoto, Seigo Sugiyama, Yoshihiro Hirata, Takanori Tokitsu, Noriaki Tabata, Koichiro Fujisue, Koichi Sugamura, Kenji Sakamoto, Kenichi Tsujita, Takeshi Matsumura, Koichi Kaikita, Seiji Hokimoto
BACKGROUND AND AIMS: This study investigated the association of leukocyte subtype counts with vascular endothelial dysfunction and future cardiovascular events in patients with coronary artery disease (CAD). METHODS: The study included 389 consecutive CAD patients (259 male, 130 female; mean age, 70.1 ± 9.9 years). The patients underwent coronary angiography, and measurement of blood parameters, including leukocyte subtype counts. RESULTS: There were 84 cardiovascular events during a mean follow-up of 586 ± 378 days...
August 25, 2016: Atherosclerosis
Isabel Gonçalves, Andreas Edsfeldt, Helen M Colhoun, Angela C Shore, Carlo Palombo, Andrea Natali, Gunilla Nordin Fredrikson, Harry Björkbacka, Maria Wigren, Eva Bengtsson, Gerd Östling, Kunihiko Aizawa, Francesco Casanova, Margaretha Persson, Kim Gooding, Phil Gates, Faisel Khan, Helen C Looker, Fiona Adams, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Li-Ming Gan, Volker Schnecke, Jan Nilsson
BACKGROUND: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. METHODS: Renin was analyzed by the Proximity Extension Assay in subjects with (n = 985) and without (n = 515) T2D participating in the SUMMIT (SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools) study and in 205 carotid endarterectomy patients...
2016: BMC Cardiovascular Disorders
Akira Fujii, Katsuji Inoue, Takayuki Nagai, Teruyoshi Uetani, Kazuhisa Nishimura, Jun Suzuki, Jun-Ichi Funada, Takafumi Okura, Jitsuo Higaki, Akiyoshi Ogimoto
BACKGROUND: In patients who have atrial fibrillation (AF) with CHADS2score of 0-1 (categorized as low-to-intermediate risk), there is little information on stratifying the risk of stroke. This study aimed to determine whether impaired endothelial function assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT) predicted left atrial blood stagnation in these patients. METHODS AND RESULTS: We enrolled 81 consecutive patients with nonvalvular AF. The reactive hyperemia index (RHI) was measured using RH-PAT...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Jin-Bae Kim, Hyun Jun Joung, Jung Myung Lee, Jong Shin Woo, Woo-Shik Kim, Kwon Sam Kim, Kyung Hye Lee, Weon Kim
BACKGROUND: Atrial fibrillation (AF) is known to be associated with several pathophysiological mechanisms including endothelial dysfunction of the heart and arterial vessels. Recent evidence suggests that new oral anticoagulant (NOAC) treatment may improve endothelial function and the inflammatory process involved in atherosclerosis in AF patients. This study is designed to determine the efficacy of NOAC therapy in the prevention of endothelial dysfunction and the progression of atherosclerosis of AF subjects...
2016: Trials
Anca Tomsa, Sara Klinepeter Bartz, Rajesh Krishnamurthy, Ramkumar Krishnamurthy, Fida Bacha
OBJECTIVE: To investigate the physical and metabolic determinants of endothelial dysfunction, an early marker of subclinical atherosclerosis, in normal weight and overweight adolescents with and without type 2 diabetes mellitus. STUDY DESIGN: A cross-sectional study of 81 adolescents: 21 normal weight, 25 overweight with normal glucose tolerance, 19 overweight with impaired glucose regulation, and 16 with type 2 diabetes mellitus underwent evaluation of reactive hyperemia index (RHI) and augmentation index (AIx) at heart rate 75 bpm by peripheral arterial tonometry; oral glucose tolerance test, lipid profile, and hyperinsulinemic-euglycemic clamp to measure insulin sensitivity; and dual energy X-ray absorptiometry scan and abdominal magnetic resonance imaging for percentage of body fat and abdominal fat partitioning...
August 18, 2016: Journal of Pediatrics
Nicola J Paine, Alan L Hinderliter, James A Blumenthal, Kirkwood F Adams, Carla A Sueta, Patricia P Chang, Christopher M O'Connor, Andrew Sherwood
INTRODUCTION: Impaired endothelial function, as assessed by brachial artery flow-mediated dilation (FMD), is an established risk factor for cardiovascular events. FMD is impaired in heart failure (HF) patients, but less is known about hyperemic brachial artery flow. We investigated the relationship between FMD and hyperemic flow with adverse clinical outcomes in HF patients. METHODS: Brachial artery FMD and hyperemic flow were assessed in 156 patients (70.5 % Male; 45...
August 2016: American Heart Journal
Joseph D Ostrem, Nicholas G Evanoff, Justin R Ryder, Julia Steinberger, Alan R Sinaiko, Katie L Bisch, Niklas M Brinck, Donald R Dengel
PURPOSE: During reactive hyperemia, the brachial artery in some individuals constricts prior to dilation. Our aim was to describe the frequency of high-flow-mediated constriction (H-FMC) in adults, and its relationship to body composition and biomarkers of cardiovascular and metabolic risk. METHODS: Two hundred forty-six adults (124 male, 122 female; 36 ± 7 years old) were assessed for H-FMC via sonographic imaging of the brachial artery. Blood pressure, glucose, insulin, lipids, and body composition assessed via dual energy X-ray absorptiometry were collected...
August 5, 2016: Journal of Clinical Ultrasound: JCU
Xian Zhang, Norbert Staimer, Tomas Tjoa, Daniel L Gillen, James J Schauer, Martin M Shafer, Sina Hasheminassab, Payam Pakbin, John Longhurst, Constantinos Sioutas, Ralph J Delfino
BACKGROUND: Short-term exposure to ambient air pollution has been associated with acute increases in cardiovascular hospitalization and mortality. However, causative chemical components and underlying pathophysiological mechanisms remain to be clarified. We hypothesized that endothelial dysfunction would be associated with mobile-source (traffic) air pollution and that pollutant components with higher oxidative potential to generate reactive oxygen species (ROS) would have stronger associations...
2016: Environmental Health: a Global Access Science Source
Cristian Del Bo', Valeria Deon, Marisa Porrini, Jonica Campolo, Marina Parolini, Patrizia Riso
The present study aimed to investigate the inter- and intraday repeatability of reactive hyperemia index (RHI) measured by Endo-PAT in healthy volunteers. Interday RHI repeatability was tested in two consecutive days in a group of thirty-one male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 h in a group of sixteen volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, coefficient of variation (CV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were measured...
July 22, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Satomi Hamada, Ai Oono, Yuri Ishihara, Yuki Hasegawa, Miho Akaza, Yuki Sumi, Yoshinori Inoue, Hajime Izumiyama, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano
Peripheral autonomic function is impaired in diabetic polyneuropathy. However, it is difficult to evaluate it due to the lack of non-invasive quantitative assessment. We aimed to establish a novel index to evaluate vascular autonomic function using reactive hyperemia peripheral arterial tonometry (RH-PAT), a widely performed endothelial function test. Sixty-five subjects were enrolled, including healthy subjects, cases with sympathetic nerve blockers, and diabetic patients. RH-PAT was performed with 5-min blood flow occlusion in unilateral arm...
July 11, 2016: Heart and Vessels
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