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https://www.readbyqxmd.com/read/28078862/a-placebo-controlled-trial-of-a-proprietary-lipid-lowering-nutraceutical-supplement-in-the-management-of-dyslipidemia
#1
M Houston, R Rountree, J Lamb, S Phipps, S Meng, B Zhang
There is an ever growing emergence in the popularity of patient-driven care. As this health and wellness model grows, inquiries into diet, lifestyle, and supplemental approaches will continue to become a focal point for the healthcare consumer. Because of this, the aim of this study is to determine the tolerability, and overall effectiveness of a proprietary multi-ingredient lipid-lowering supplement in subjects with dyslipidemia. Forty participants were recruited for a single-center, double-blind randomized, placebocontrolled trial...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28053201/evidence-that-supports-the-prescription-of-low-carbohydrate-high-fat-diets-a-narrative-review
#2
Timothy David Noakes, Johann Windt
Low-carbohydrate high-fat (LCHF) diets are a highly contentious current topic in nutrition. This narrative review aims to provide clinicians with a broad overview of the effects of LCHF diets on body weight, glycaemic control and cardiovascular risk factors while addressing some common concerns and misconceptions. Blood total cholesterol and LDL-cholesterol concentrations show a variable, highly individual response to LCHF diets, and should be monitored in patients adhering to this diet. In contrast, available evidence from clinical and preclinical studies indicates that LCHF diets consistently improve all other markers of cardiovascular risk-lowering elevated blood glucose, insulin, triglyceride, ApoB and saturated fat (especially palmitoleic acid) concentrations, reducing small dense LDL particle numbers, glycated haemoglobin (HbA1c) levels, blood pressure and body weight while increasing low HDL-cholesterol concentrations and reversing non-alcoholic fatty liver disease (NAFLD)...
January 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28038378/the-causal-effects-of-alcohol-on-lipoprotein-subfraction-and-triglyceride-levels-using-a-mendelian-randomization-analysis-the-nagahama-study
#3
Yasuharu Tabara, Hidenori Arai, Yuhko Hirao, Yoshimitsu Takahashi, Kazuya Setoh, Takahisa Kawaguchi, Shinji Kosugi, Yasuki Ito, Takeo Nakayama, Fumihiko Matsuda
BACKGROUND: Light-to-moderate alcohol consumption may increase circulating high-density lipoprotein cholesterol (HDL-C) levels and decrease low-density lipoprotein cholesterol (LDL-C) levels. However, the effect of alcohol on biologically important lipoprotein subfractions remains largely unknown. Here we aimed to clarify the effects of alcohol on lipoprotein subfractions using a Mendelian randomization analysis. METHODS: The study subjects consisted of 8364 general Japanese individuals...
December 22, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28029752/effects-of-baricitinib-on-lipid-apolipoprotein-and-lipoprotein-particle-profiles-in-a-phase-2b-study-in-patients-with-active-rheumatoid-arthritis
#4
Joel Kremer, Mark C Genovese, Edward Keystone, Peter C Taylor, Steven H Zuckerman, Giacomo Ruotolo, Douglas E Schlichting, Victoria L Crotzer, Eric Nantz, Scott D Beattie, William L Macias
Objective To assess the effects of baricitinib on lipid profile in patients with moderate-to-severe rheumatoid arthritis. Methods Once-daily baricitinib (1, 2, 4, or 8-mg) or placebo was studied in 301 randomized patients. Changes in lipid profile, particle size, and number were assessed at weeks 12/24; associations with clinical efficacy were evaluated. Apolipoproteins were assessed at weeks 4/12 for the placebo, and 4- and 8-mg baricitinib groups. Results Baricitinib treatment resulted in dose-dependent increases by week 12 in serum lipids (low-density lipoprotein cholesterol [LDL-C]: 3...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27816804/persistent-changes-in-lipoprotein-lipids-after-a-single-infusion-of-ascending-doses-of-mdco-216-apoa-imilano-popc-in-healthy-volunteers-and-stable-coronary-artery-disease-patients
#5
Herman J Kempen, Monica Gomaraschi, Sara Simonelli, Laura Calabresi, Matthijs Moerland, James Otvos, Elias Jeyarajah, David Kallend, Peter L J Wijngaard
BACKGROUND AND AIMS: Effects of single ascending doses of MDCO-216 on plasma lipid and lipoprotein levels were assessed in human healthy volunteers and in patients with stable coronary artery disease (CAD). METHODS: MDCO-216 was infused at a single dose of 5, 10, 20, 30 or 40 mg/kg over 2 h and blood was collected at 2, 4, 8, 24, 48, 168 and 720 h after start of infusion (ASOI). Lipoprotein lipids were assessed by FLPC and by 1H NMR. RESULTS: Plasma concentrations of free cholesterol (FC) displayed a rapid and dose-dependent rise, peaking at 8 h, but remaining above baseline until 48 h ASOI, whereas levels of esterified cholesterol (CE) increased at lower doses but not at higher doses, and even decreased below baseline at the highest dose...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27784733/comprehensive-analysis-of-established-dyslipidemia-associated-loci-in-the-diabetes-prevention-program
#6
Tibor V Varga, Alexandra H Winters, Kathleen A Jablonski, Edward S Horton, Prajakta Khare-Ranade, William C Knowler, Santica M Marcovina, Frida Renström, Karol E Watson, Ronald Goldberg, José C Florez, Toni I Pollin, Paul W Franks
BACKGROUND: We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid and lipid subfraction levels in the Diabetes Prevention Program randomized controlled trial. METHODS AND RESULTS: We tested gene treatment interactions in relation to baseline-adjusted follow-up blood lipid concentrations (high-density lipoprotein [HDL] and low-density lipoprotein-cholesterol, total cholesterol, and triglycerides) and lipoprotein subfraction particle concentrations and size in 2993 participants with pre-diabetes...
December 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27740536/treatment-of-hiv-infection-with-a-raltegravir-based-regimen-increases-ldl-levels-but-improves-hdl-cholesterol-efflux-capacity
#7
Nicholas T Funderburg, Dihua Xu, Martin P Playford, Aditya A Joshi, Adriana Andrade, Daniel R Kuritzkes, Michael M Lederman, Nehal N Mehta
BACKGROUND: Persons infected with HIV often have altered lipid profiles that may be affected by antiretroviral therapies (ART). Traditional lipid measurements may be insufficient to assess cardiovascular disease (CVD) risk in this population. METHODS: We report results from 39 ART-naïve participants in a substudy of A5248, a single-arm study of raltegravir (RAL), emtricitabine/tenofovir administration. Samples were collected at baseline, 12, 24, and 48 weeks after ART initiation...
October 14, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27736980/patients-with-rheumatoid-arthritis-show-altered-lipoprotein-profiles-with-dysfunctional-high-density-lipoproteins-that-can-exacerbate-inflammatory-and-atherogenic-process
#8
Jae-Yong Kim, Eun-Young Lee, Jin Kyun Park, Yeong Wook Song, Jae-Ryong Kim, Kyung-Hyun Cho
OBJECTIVE: In order to identify putative biomarkers in lipoprotein, we compared lipid and lipoprotein properties between rheumatoid arthritis (RA) patients and control with similar age. METHODS: We analyzed four classes of lipoproteins (VLDL, LDL, HDL2, HDL3) from both male (n = 8, 69±4 year-old) and female (n = 25, 53±7 year-old) rheumatoid arthritis (RA) patients as well as controls with similar age (n = 13). RESULTS: Although RA group showed normal levels of total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, and glucose, however, the RA group showed significantly reduced high-density lipoprotein (HDL)-C level and ratio of HDL-C/TC...
2016: PloS One
https://www.readbyqxmd.com/read/27678443/an-evidence-based-analysis-of-the-national-lipid-association-recommendations-concerning-non-hdl-c-and-apob
#9
Allan D Sniderman, Peter P Toth, George Thanassoulis, Curt D Furberg
BACKGROUND: The National Lipid Association (NLA) selected non-HDL-C as its prime index of the cardiovascular risk associated with the apoB lipoproteins. ApoB was recommended only as an optional secondary target after low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) targets were achieved. OBJECTIVE: The aims of this analysis were to determine whether (1) all relevant uses of apoB were considered by the NLA; (2) all the relevant evidence was considered by the NLA panel; and (3) all the evidence that was considered was interpreted correctly...
September 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27596163/differences-in-glyca-and-lipoprotein-particle-parameters-may-help-distinguish-acute-kawasaki-disease-from-other-febrile-illnesses-in-children
#10
Margery A Connelly, Chisato Shimizu, Deborah A Winegar, Irina Shalaurova, Ray Pourfarzib, James D Otvos, John T Kanegaye, Adriana H Tremoulet, Jane C Burns
BACKGROUND: Glycosylation patterns of serum proteins, such as α1-acid glycoprotein, are modified during an acute phase reaction. The response of acute Kawasaki disease (KD) patients to IVIG treatment has been linked to sialic acid levels on native IgG, suggesting that protein glycosylation patterns vary during the immune response in acute KD. Additionally, the distribution and function of lipoprotein particles are altered during inflammation. Therefore, the aim of this study was to explore the potential for GlycA, a marker of protein glycosylation, and the lipoprotein particle profile to distinguish pediatric patients with acute KD from those with other febrile illnesses...
September 5, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27581580/compared-with-powdered-lutein-a-lutein-nanoemulsion-increases-plasma-and-liver-lutein-protects-against-hepatic-steatosis-and-affects-lipoprotein-metabolism-in-guinea-pigs
#11
Ana Gabriela Murillo, David Aguilar, Gregory H Norris, Diana M DiMarco, Amanda Missimer, Siqi Hu, Joan A Smyth, Sarah Gannon, Christopher N Blesso, Yangchao Luo, Maria Luz Fernandez
BACKGROUND: It is not clear how oil-in-water nanoemulsions of lutein may affect bioavailability and consequently alter lipoprotein metabolism, oxidative stress, and inflammation. OBJECTIVE: The bioavailability as well as effects of a powdered lutein (PL) and an oil-in-water lutein nanoemulsion (NANO; particle size: 254.2 nm; polydispersity index: 0.29; and ζ-potential: -65 mV) on metabolic variables in liver, plasma, and adipose tissue in a guinea pig model of hepatic steatosis were evaluated...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27575649/mendelian-randomization-analysis-in-three-japanese-populations-supports-a-causal-role-of-alcohol-consumption-in-lowering-low-density-lipid-cholesterol-levels-and-particle-numbers
#12
Yasuharu Tabara, Hirotsugu Ueshima, Naoyuki Takashima, Takashi Hisamatsu, Akira Fujiyoshi, Maryam Zaid, Masaki Sumi, Katsuhiko Kohara, Tetsuro Miki, Katsuyuki Miura
BACKGROUND AND AIMS: While alcohol consumption is known to increase plasma high-density lipoprotein (HDL) cholesterol levels, its relationship with low-density lipoprotein (LDL) cholesterol levels is unclear. Aldehyde dehydrogenase 2 (ALDH2) is a rate-controlling enzyme in alcohol metabolism, but a large number of Japanese people have the inactive allele. Here, we conducted a Mendelian randomization analysis using the ALDH2 genotype to clarify a causal role of alcohol on circulating cholesterol levels and lipoprotein particle numbers...
August 24, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27547014/hepatitis-c-virus-g1b-infection-decreases-the-number-of-small-low-density-lipoprotein-particles
#13
Chika Kinoshita, Tomohisa Nagano, Nobuyoshi Seki, Yoichi Tomita, Tomonori Sugita, Yuta Aida, Munenori Itagaki, Kenichi Satoh, Satoshi Sutoh, Hiroshi Abe, Akihito Tsubota, Yoshio Aizawa
AIM: To investigate how hepatitis C virus (HCV) G1b infection influences the particle number of lipoproteins. METHODS: The numbers of lipoprotein particles in fasting sera from 173 Japanese subjects, 82 with active HCV G1b infection (active HCV group) and 91 with cleared HCV infection (SVR group), were examined. Serum lipoprotein was fractionated by high-performance liquid chromatography into twenty fractions. The cholesterol and triglyceride concentrations in each fraction were measured using LipoSEARCH...
August 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27417914/common-medications-used-by-patients-with-type-2-diabetes-mellitus-what-are-their-effects-on-the-lipid-profile
#14
REVIEW
Paul D Rosenblit
Dyslipidemia is the most fundamental risk factor for atherosclerotic cardiovascular disease (ASCVD). In clinical practice, many commonly prescribed medications can alter the patient's lipid profile and, potentially, the risk for ASCVD-either favorably or unfavorably. The dyslipidemia observed in type 2 diabetes mellitus (T2DM) can be characterized as both ominous and cryptic, in terms of unrecognized, disproportionately elevated atherogenic cholesterol particle concentrations, in spite of deceptively and relatively lower levels of low-density lipoprotein cholesterol (LDL-C)...
July 14, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27213832/influence-of-maternal-hypercholesterolemia-and-phytosterol-intervention-during-gestation-and-lactation-on-dyslipidemia-and-hepatic-lipid-metabolism-in-offspring-of-syrian-golden-hamsters
#15
Jie Liu, Aadil Iqbal, Amy Raslawsky, Richard W Browne, Mulchand S Patel, Todd C Rideout
SCOPE: Although there is a normal physiological rise in maternal lipids during pregnancy, excessive maternal hyperlipidemia during pregnancy increases cardiovascular disease risk for both the mother and offspring. There are limited safe lipid-lowering treatment options for use during pregnancy, therefore, we evaluated the influence of maternal phytosterol (PS) supplementation on lipid and lipoprotein metabolism in mothers and progeny. METHODS AND RESULTS: Female Syrian golden hamsters were randomly assigned to three diets throughout prepregnancy, gestation, and lactation (n = 6/group): (i) Chow (Chow), (ii) chow with 0...
October 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27206949/superiority-of-lipoprotein-particle-number-to-detect-associations-with-arterial-thickness-and-stiffness-in-obese-youth-with-and-without-prediabetes
#16
Amy S Shah, W Sean Davidson, Zhiqian Gao, Lawrence M Dolan, Thomas R Kimball, Elaine M Urbina
BACKGROUND: The nuclear magnetic resonance (NMR) lipoprotein profile provides additional cardiovascular risk information beyond traditional lipids in high-risk adults. Similar studies have not been conducted in youth. OBJECTIVE: To evaluate the relationship between the NMR profile and preclinical vascular measures in youth. METHODS: We studied 96 obese youth with prediabetes (mean age = 18.1 ± 3.6 years, 63% female, 78% African American) and 118 obese normoglycemic controls (mean age = 18...
May 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27055962/large-high-density-lipoprotein-particle-number-is-independently-associated-with-microvascular-function-in-patients-with-well-controlled-low-density-lipoprotein-concentration-a-vasodilator-stress-magnetic-resonance-perfusion-study
#17
Akhil Narang, Victor Mor-Avi, Nicole M Bhave, Giacomo Tarroni, Cristiana Corsi, Michael H Davidson, Roberto M Lang, Amit R Patel
BACKGROUND: Abnormalities in total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides are associated with microvascular dysfunction. Recent studies suggest that lipid subfractions better predict atherogenic burden than a routine lipid panel. We sought to determine, whether lipid subfractions are more strongly associated with microvascular function and subclinical atherosclerosis, than conventional lipid measurements using vasodilator stress cardiovascular magnetic resonance (CMR)...
March 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27024174/ask-the-doctor-i-had-a-stent-put-in-several-years-ago-at-age-59-thanks-to-a-better-diet-more-exercise-a-statin-and-niacin-my-ldl-hdl-and-triglycerides-are-excellent-my-latest-nuclear-stress-test-showed-some-ischemia-even-though-i-am-not-having-any-symptoms
#18
https://www.readbyqxmd.com/read/26997169/lipoprotein-composition-in-patients-with-type-1-diabetes-mellitus-impact-of-lipases-and-adipokines
#19
Thomas A Hughes, Rossana M Calderon, Sylvia Diaz, Armando J Mendez, Ronald B Goldberg
OBJECTIVE: High cardiovascular mortality in patients with type 1 diabetes (T1DM) is widely recognized. Paradoxically, these patients have been shown to have elevated HDL-C and reduced apoB-containing lipoproteins. The purpose of this investigation was to further characterize the lipoprotein composition in T1DM and to assess the role that lipases and adipokines may play in these differences. METHODS: T1DM patients (89) attending the Diabetes Clinic at the University of Miami and 42 healthy controls were recruited...
May 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26642102/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-androgen-excess-and-pcos-society-disease-state-clinical-review-guide-to-the-best-practices-in-the-evaluation-and-treatment-of-polycystic-ovary-syndrome-part-2
#20
REVIEW
Neil F Goodman, Rhoda H Cobin, Walter Futterweit, Jennifer S Glueck, Richard S Legro, Enrico Carmina
Polycystic ovary syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists and the Androgen Excess Society aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2014. Insulin resistance is believed to play an intrinsic role in the pathogenesis of PCOS. The mechanism by which insulin resistance or insulin give rise to oligomenorrhea and hyperandrogenemia, however, is unclear...
December 2015: Endocrine Practice
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