keyword
https://read.qxmd.com/read/38316225/adverse-events-of-the-single-operator-cholangioscopy-system-a-maude-database-analysis
#21
JOURNAL ARTICLE
Saurabh Chandan, Daryl Ramai, Daniel Mozell, Antonio Facciorusso, David L Diehl, Gursimran S Kochhar
BACKGROUND AND AIMS: SpyGlass single operator cholangioscopy (SOC) system is generally considered safe but adds additional risks to those associated with standard endoscopic retrograde cholangiopancreatography. METHODS: We evaluated adverse events (AEs) with the SpyGlass System reported in the United States Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database between January 2016 & August 2023. RESULTS: A total of 2331 device problems (SpyGlass DS:1301, SpyGlass DS II:1010) were reported...
February 3, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38312483/novel-high-strength-polyester-composite-scaffolds-for-bone-regeneration
#22
JOURNAL ARTICLE
Sara Katebifar, Michael Arul, Sama Abdulmalik, Xiaojun Yu, Joseph F Alderete, Sangamesh G Kumbar
Repair of critical sized bone defects, particularly in load-bearing areas, is a major clinical problem that requires surgical intervention and implantation of biological or engineered grafts. For load-bearing sites, it is essential to use engineered grafts that have both sufficient mechanical strength and appropriate pore properties to support bone repair and tissue regeneration. Unfortunately, the mechanical properties of such grafts are often compromised due to the creation of pores required to facilitate tissue ingrowth following implantation...
December 2023: Polymers for Advanced Technologies
https://read.qxmd.com/read/38307362/clotrimazole-causes-membrane-depolarization-and-induces-sub-g-0-cell-arrest-in-leishmania-donovani
#23
JOURNAL ARTICLE
Anindita Paul, Pradyot Kumar Roy, Neerupudi Kishore Babu, Sushma Singh
Clotrimazole is an FDA approved drug and is widely used as an antifungal agent. An extensive body of research is available about its mechanism of action on various cell types but its mode of killing of Leishmania donovani parasites is unknown. L. donovani causes Visceral Leishmaniasis which is a public health problem with limited treatment options. Its present chemotherapy is expensive, has adverse effects and is plagued with drug resistance issues. In this study we have explored the possibility of repurposing clotrimazole as an antileishmanial drug...
January 31, 2024: Acta Tropica
https://read.qxmd.com/read/38299934/better-wound-care-begins-with-better-evidence-outcomes-of-the-wound-care-evidence-summit%C3%A2
#24
JOURNAL ARTICLE
Marissa Janine Carter, Marcia Nusgart, Winifred Hayes
In 2022 the Alliance of Wound Care Stakeholders convened the 2-day Wound Care Evidence Summit™. The Summit brought together a multidisciplinary group of stakeholders that included payers, government agency policymakers, prominent researchers, wound care medical specialty societies, patient and clinical associations, wound care clinics, and manufacturers to discuss wound care evidence and coverage issues. The Summit focused on a wide variety of wound care topics, with an emphasis on the processes payers use to create their coverage policies and the type, quantity, and characteristics of clinical evidence payers require...
February 1, 2024: Advances in Wound Care
https://read.qxmd.com/read/38261135/simvastatin-significantly-reduced-alcohol-induced-cardiac-damage-in-adolescent-mice
#25
JOURNAL ARTICLE
Makgotso Nchodu, Alice Efuntayo, Robin du Preez, Hasiena Ali, Oladiran I Olateju
Alcohol abuse by adolescents is becoming a serious health concern as they often progress to becoming alcoholics later in life which may lead to heart problems. Chronic alcohol use alters the cardiac function and structure, such as haemodynamic changes, weakening and loss of cardiomyocytes, myocardial fibrosis, and inflammation. Simvastatin is a commonly used drug for the treatment and management of various cardiovascular problems but information on its protective effects against alcohol-induced cardiomyocyte hypertrophy, fibrosis, and inflammation is lacking in the literature...
January 23, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38237586/sars-cov-2-infection-causes-dopaminergic-neuron-senescence
#26
JOURNAL ARTICLE
Liuliu Yang, Tae Wan Kim, Yuling Han, Manoj S Nair, Oliver Harschnitz, Jiajun Zhu, Pengfei Wang, So Yeon Koo, Lauretta A Lacko, Vasuretha Chandar, Yaron Bram, Tuo Zhang, Wei Zhang, Feng He, Chendong Pan, Junjie Wu, Yaoxing Huang, Todd Evans, Paul van der Valk, Maarten J Titulaer, Jochem K H Spoor, Robert L Furler O'Brien, Marianna Bugiani, Wilma D J Van de Berg, Robert E Schwartz, David D Ho, Lorenz Studer, Shuibing Chen
COVID-19 patients commonly present with signs of central nervous system and/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA neurons triggers an inflammatory and cellular senescence response. High-throughput screening in hPSC-derived DA neurons identified several FDA-approved drugs that can rescue the cellular senescence phenotype by preventing SARS-CoV-2 infection...
January 10, 2024: Cell Stem Cell
https://read.qxmd.com/read/38227893/financial-losses-due-to-fumonisin-contamination-in-the-texas-high-plains-maize
#27
JOURNAL ARTICLE
Ashli A Brown, Mary Sasser, Tim Herrman
Fumonisins are one of the main problems affecting maize production in the Texas High Plains (THP), where its agroclimatic conditions make it a perennial hotspot for mycotoxin contamination. In 2017, a fumonisin outbreak in the THP maize motivated stakeholders' request to repeal a subsection of the Texas Administrative Code, §61.61(a)(7) (Fumonisin Rule), and its related Texas Feed Industry Memorandum (Memo 5-20), which previously permitted the blending of maize containing high fumonisin levels with maize containing ≥ 5 mg/kg under state authority, and pivot to FDA fumonisin guidance...
January 16, 2024: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://read.qxmd.com/read/38203213/antimicrobial-activity-of-n-n-diethyldithiocarbamate-against-ureaplasma-parvum-and-ureaplasma-urealyticum
#28
JOURNAL ARTICLE
Małgorzata Biernat-Sudolska, Danuta Rojek-Zakrzewska, Kamil Drożdż, Anna Bilska-Wilkosz
Ureaplasma species ( Ureaplasma spp.) are commonly found as commensals in the human urogenital tracts, although their overgrowth can lead to infection in the urogenital tract and at distal sites. Furthermore, ureaplasmas lack a cell wall and do not synthesize folic acid, which causes all β-lactam and glycopeptide antibiotics, and sulfonamides and diaminopyrimidines, to be of no value. The antibiotics used in therapy belong to the fluoroquinolone, tetracycline, chloramphenicol and macrolide classes. However, the growing incidence of antibiotic-resistant Ureaplasma spp...
December 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38197372/tofacitinib-in-dermatology-a-potential-opportunity-for-topical-applicability-through-novel-drug-delivery-systems
#29
REVIEW
Akanksha Mahajan, Gajanand Sharma, Anil Thakur, Bhupinder Singh, Hitaishi Mehta, Neeraj Mittal, Sunil Dogra, O P Katare
Tofacitinib is a first-generation JAK inhibitor approved by the US FDA for treating rheumatoid arthritis. It exhibits a broad-spectrum inhibitory effect with abilities to block JAK-STAT signalling. The primary objective of this review is to obtain knowledge about cutting-edge methods for effectively treating a variety of skin problems by including tofacitinib into formulations that are based on nanocarriers. The review also highlights clinical trials and offers an update on published clinical patents. Nanocarriers provide superior performance compared to conventional treatments in terms of efficacy, stability, drug bioavailability, target selectivity and sustained drug release...
January 2024: Nanomedicine
https://read.qxmd.com/read/38195724/long-lasting-blocking-of-interoceptive-effects-of-cocaine-by-a-highly-efficient-cocaine-hydrolase-in-rats
#30
JOURNAL ARTICLE
Huimei Wei, Johnathan E LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6). The present study examined the effectiveness and duration of CocH5-Fc(M6) in blocking interoceptive effects of cocaine by performing cocaine discrimination tests in rats, demonstrating that the duration of CocH5-Fc(M6) in blocking cocaine discrimination was dependent on cocaine dose and CocH5-Fc(M6) plasma concentration...
January 9, 2024: Scientific Reports
https://read.qxmd.com/read/38194773/peptide-drug-conjugates-a-new-paradigm-for-targeted-cancer-therapy
#31
REVIEW
Mo Wang, Jiawei Liu, Mingjing Xia, Libinghan Yin, Ling Zhang, Xifu Liu, Yu Cheng
Peptide-drug conjugates (PDCs) are the new hope for targeted therapy after antibody-drug conjugates (ADCs). Compared with ADCs, the core advantages of PDCs are enhanced tissue penetration, easier chemical synthesis, and lower production costs. Two PDCs have been approved by the US Food and Drug Administration (FDA) for the treatment of cancer. The therapeutic effects of PDCs are remarkable, but PDCs also encounter problems when used as targeted therapeutics, such as poor stability, a short blood circulation time, a long research and development time frame, and a slow clinical development process...
January 1, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38188941/anti-obesity-and-metabolic-benefits-of-metformin-comparison-of-different-delivery-routes
#32
JOURNAL ARTICLE
Mehrnaz Abbasi, Zhaoyang Fan, John A Dawson, Shu Wang
Obesity is a severe public health problem. Healthy lifestyle interventions are commonly recommended for fighting obesity. But they are hard to follow and have low efficacy. Pharmacotherapy and surgery are of high efficacy but are beset with side effects. Browning subcutaneous white adipose tissue (WAT) is a practical and efficient approach for combating obesity. Metformin, a commonly used FDA-approved antidiabetic drug, is potent to induce browning of WAT through phosphorylation and activation of AMP-activated protein kinase...
January 2024: Journal of Drug Delivery Science and Technology
https://read.qxmd.com/read/38178284/effect-of-acid-suppressant-medications-on-the-laxative-action-of-magnesium-preparations-in-patients-with-opioid-induced-constipation-a-pharmacovigilance-analysis-of-the-fda-adverse-event-reporting-system
#33
JOURNAL ARTICLE
M Maezawa, M Inoue, R Satake, W Wakabayashi, K Oura, F Goto, K Miyasaka, S Hirofuji, M Iwata, T Suzuki, H Tanaka, S Nishida, S Shimizu, A Suzuki, K Iguchi, M Nakamura
Objective : Magnesium oxide is widely used for treating opioid-induced constipation, a serious analgesic-associated problem. Opioid analgesic users are often prescribed non-steroidal anti-inflammatory drugs, which are sometimes combined with acid suppressants to prevent gastrointestinal adverse events. Magnesium preparations combined with acid suppressants may diminish magnesium preparations' laxative effect. This study was aimed at evaluating the effect of magnesium preparations combined with acid suppressants on the incidence of opioid-induced constipation by using the Food and Drug Administration Adverse Event Reporting System...
December 4, 2023: Die Pharmazie
https://read.qxmd.com/read/38159887/biperiden-reverses-the-increase-in-50-khz-ultrasonic-vocalizations-but-not-the-increase-in-locomotor-activity-induced-by-cocaine
#34
JOURNAL ARTICLE
Thais C S Saldanha, William N Sanchez, Paola Palombo, Fábio C Cruz, José Carlos F Galduróz, Rainer K W Schwarting, Roberto Andreatini, Claudio da Cunha, José Augusto Pochapski
Cocaine use disorder (CUD) is a worldwide public health problem, associated with severe psychosocial and economic impacts. Currently, no FDA-approved treatment is available for CUD. However, an emerging body of evidence from clinical and preclinical studies suggests that biperiden, an M1 muscarinic receptor antagonist, presents potential therapeutic use for CUD. These studies have suggested that biperiden may reduce the reinforcing effects of cocaine. It is well established that rodents emit 50-kHz ultrasonic vocalizations (USV) in response to natural rewards and stimulant drugs, including cocaine...
December 28, 2023: Behavioural Brain Research
https://read.qxmd.com/read/38151513/stacker-a-novel-smiles-based-stacked-approach-for-the-accelerated-and-efficient-discovery-of-er%C3%AE-and-er%C3%AE-antagonists
#35
JOURNAL ARTICLE
Nalini Schaduangrat, Nutta Homdee, Watshara Shoombuatong
The role of estrogen receptors (ERs) in breast cancer is of great importance in both clinical practice and scientific exploration. However, around 15-30% of those affected do not see benefits from the usual treatments owing to the innate resistance mechanisms, while 30-40% will gain resistance through treatments. In order to address this problem and facilitate community-wide efforts, machine learning (ML)-based approaches are considered one of the most cost-effective and large-scale identification methods. Herein, we propose a new SMILES-based stacked approach, termed StackER, for the accelerated and efficient identification of ERα and ERβ inhibitors...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38146360/medication-use-and-associated-factors-among-indonesian-pregnant-women-a-cross-sectional-study
#36
JOURNAL ARTICLE
Raden Tina Dewi Judistiani, Aprilya Eka Pratiwi, Kurnia Wahyudi, Agnesya Gunawan, Anita Rahmawati, Rovina Ruslami
PURPOSE: Medication use during pregnancy should be considered carefully due to its potential harm to the fetus. Data on prescribed medication and self-medication among Indonesian pregnant women is lacking. This study aimed to assess the prevalence and factors related to medication use among pregnant women attending antenatal care services at community health posts in Soreang, a suburban area in Indonesia. PATIENTS AND METHODS: A cross-sectional community-based study was conducted...
2023: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38138158/lariat-or-atriclip-complications-profile-and-comparison-in-patients-with-atrial-fibrillations-based-on-manufacturer-and-user-facility-device-experience-database
#37
JOURNAL ARTICLE
Radosław Litwinowicz, Jakub Batko, Jakub Rusinek, Wojciech Olejek, Daniel Rams, Mariusz Kowalewski, Krzysztof Bartuś, Marian Burysz
Background and Objectives: Left atrial appendage closure is an alternative treatment to reduce thromboembolism in patients with atrial fibrillation in whom oral anticoagulation (OAC) is contraindicated. The aim of this study was to evaluate the complications profiles of the LARIAT and AtriClip devices and perform a comparison between them based on the MAUDE (Manufacturer and User Facility Device Experience) database. Materials and Methods: The Manufacturer and User Facility Device Experience database was searched on 15 January 2023...
November 21, 2023: Medicina
https://read.qxmd.com/read/38133447/assessment-of-community-awareness-and-screening-of-chagas-disease-in-the-latin-american-community-of-greater-new-orleans
#38
JOURNAL ARTICLE
Claudia Herrera, Kerlly J Bernabé, Eric Dumonteil, James DeCuir, Julie M Thompson, Mariana Avendano, Weihong Tu, Maxwell M Leonhardt, Bianka A Northland, Jynx Frederick, Bryn Prieto, Angel Paternina-Caicedo, Emma Ortega, Maria Fonseca, Marcela Hincapie, Margarita Echeverri
Chagas disease is a public health problem in the Americas, from the southern United States (USA) to Argentina. In the USA, less than 1% of domestic cases have been identified and less than 0.3% of total cases have received treatment. Little is known about affected immigrant Latin American communities. A prospective study was conducted to assess knowledge about Chagas disease among the Latin American community living in the Greater New Orleans area. Participants answered a baseline questionnaire, viewed a short educational video presentation, completed a post-presentation questionnaire, and were screened with an FDA-approved blood rapid diagnostic test (RDT)...
December 5, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38132111/lipid-lowering-drug-gemfibrozil-protects-mice-from-tay-sachs-disease-via-peroxisome-proliferator-activated-receptor-%C3%AE
#39
JOURNAL ARTICLE
Sumita Raha, Debashis Dutta, Ramesh K Paidi, Kalipada Pahan
Tay-Sachs disease (TSD) is a progressive heritable neurodegenerative disorder characterized by the deficiency of the lysosomal β-hexosaminidase enzyme (Hex-/- ) and the storage of GM2 ganglioside, as well as other related glycoconjugates. Along with motor difficulties, TSD patients also manifest a gradual loss of skills and behavioral problems, followed by early death. Unfortunately, there is no cure for TSD; however, research on treatments and therapeutic approaches is ongoing. This study underlines the importance of gemfibrozil (GFB), an FDA-approved lipid-lowering drug, in inhibiting the disease process in a transgenic mouse model of Tay-Sachs...
December 8, 2023: Cells
https://read.qxmd.com/read/38103416/the-quality-of-drugs-and-drug-products-always-guaranteed
#40
REVIEW
Helmut Buschmann, Norbert Handler, Ulrike Holzgrabe
To ensure the efficacy, safety, and quality of drugs, several national and international guidelines and regulatory requirements exist. The most important international regulatory framework for quality is the collection of the guidelines ICH Q1-Q14 (International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use), which form the basis for the development and approval of medicinal products. Additionally, international and national pharmacopoeias and national regulatory authorities like Food and Drug Administration (FDA) and European Directory for the Quality of Medicines and HealthCare (EDQM) have to be considered during the lifecycle of a drug...
December 10, 2023: Journal of Pharmaceutical and Biomedical Analysis
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