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https://www.readbyqxmd.com/read/27917682/the-preclinical-discovery-and-development-of-bortezomib-for-the-treatment-of-mantle-cell-lymphoma
#1
Richard Arkwright, Tri Minh Pham, Jeffrey A Zonder, Q Ping Dou
Introduction- Mantle cell lymphoma (MCL) is an incurable, often aggressive B-cell malignancy. Bortezomib (BTZ), the 20S proteasome inhibitor was originally developed and approved for treatment of relapsed refractory multiple myeloma, and subsequently approved for treatment of MCL. BTZ's single-agent activity induces clinical responses in approximately one-third of relapsed MCL patients. BTZ-containing combination therapies have further improved the quality and duration of clinical responses compared to standard chemotherapies in previously untreated MCL patients...
December 3, 2016: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27910713/sn-38-loading-capacity-of-hydrophobic-polymer-blend-nanoparticles-formulation-optimization-and-efficacy-evaluation
#2
Simona Dimchevska, Nikola Geskovski, Gjorgji Petruševski, Marina Chacorovska, Riste Popeski-Dimovski, Sonja Ugarkovic, Katerina Goracinova
One of the most important problems in nanoencapsulation of extremely hydrophobic drugs is poor drug loading due to rapid drug crystallization outside the polymer core. The effort to use nanoprecipitation, as a simple one-step procedure with good reproducibility and FDA approved polymers like Poly(lactic-co-glycolic acid) (PLGA) and Polycaprolactone (PCL), will only potentiate this issue. Considering that drug loading is one of the key defining characteristics, in this study we attempted to examine whether the nanoparticle core composed of two hydrophobic polymers will provide increased drug loading for 7-Ethyl-10-hydroxy-camptothecin (SN-38), relative to nanoparticles prepared using individual polymers...
December 2, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27888609/effects-of-lorcaserin-on-pre-existing-valvulopathy-a-pooled-analysis-of-phase-3-trials
#3
Neil J Weissman, Steven R Smith, Randi Fain, Nancy Hall, William R Shanahan
OBJECTIVE: To evaluate the effects of lorcaserin in patients with pre-existing Food and Drug Administration (FDA)-defined valvulopathy. METHODS: This is a pooled, post hoc analysis of three Phase 3 studies. BLOOM and BLOSSOM patients were 18 to 65 years of age without diabetes and with a body mass index (BMI) of 27 to 29.9 kg/m(2) and ≥1 weight-related comorbidity or a BMI of 30 to 45 kg/m(2) . BLOOM-DM patients had a BMI of 27 to 45 kg/m(2) and type 2 diabetes...
November 26, 2016: Obesity
https://www.readbyqxmd.com/read/27865835/cholinesterases-inhibition-and-molecular-modeling-studies-of-piperidyl-thienyl-and-2-pyrazoline-derivatives-of-chalcones
#4
Muhammad Shakil Shah, Shafi Ullah Khan, Syeda Abida Ejaz, Saifullah Afridi, Syed Umar Farooq Rizvi, Muhammad Najam-Ul-Haq, Jamshed Iqbal
Super-activation of cholinesterases (acetylcholinesterase and butyrylcholinesterase) are linked to various neurological problems most precisely Alzheimer's disease (AD), which leads to senile dementia. Therefore, cholinesterases (AChE & BChE) inhibition are considered as a promising strategy for the treatment of Alzheimer's disease. FDA approved drugs for the treatment of AD, belong to a group of cholinesterase inhibitors. However, none of them is able to combat or completely abrogate the disease progression...
November 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27864902/quantitative-structure-activity-relationship-and-molecular-docking-revealed-a-potency-of-anti-hepatitis-c-virus-drugs-against-human-corona-viruses
#5
Abdo A Elfiky, Samah M Mahdy, Wael M Elshemey
A number of human coronaviruses (HCoVs) were reported in the last and present centuries. Some outbreaks of which (e.g. SARS and MERS CoVs) caused the mortality of hundreds of people worldwide. The problem of finding a potent drug against HCoV strains lies in the inability of finding a drug that stops the viral replication through inhibiting its important proteins. In spite of its limited efficacy and potential side effects, Ribavirin is extensively used as a first choice against HCoVs. Therefore, scientists reverted towards the investigation of different drugs that can more specifically target proteins...
November 19, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27855284/development-of-live-attenuated-arenavirus-vaccines-based-on-codon-deoptimization-of-the-viral-glycoprotein
#6
Benson Y H Cheng, Aitor Nogales, Juan Carlos de la Torre, Luis Martínez-Sobrido
Several arenaviruses, chiefly Lassa (LASV) in West Africa, cause hemorrhagic fever (HF) disease in humans and pose important public health problems in their endemic regions. To date, there are no FDA-approved arenavirus vaccines and current anti-arenaviral therapy is limited to the use of ribavirin that has very limited efficacy. In this work we document that a recombinant prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) with a codon deoptimized (CD) surface glycoprotein (GP), rLCMV/CD, exhibited wild type (WT)-like growth properties in cultured cells despite barely detectable GP expression levels in rLCMV/CD-infected cells...
November 14, 2016: Virology
https://www.readbyqxmd.com/read/27833693/e-cigarette-blast-injury-complex-facial-fractures-and-pneumocephalus
#7
Benjamin A Archambeau, Stephanie Young, Carol Lee, Troy Pennington, Christopher Vanderbeek, Dan Miulli, John Culhane, Michael Neeki
Electronic cigarettes (also known as e-cigarettes or e-cigs) are becoming a popular method of recreational nicotine use over recent years. The growth of new brands and devices has been outpacing the FDA's ability to regulate them. As a result, some of these devices fail without warning, most likely from malfunction of the lithium-ion batteries that are in close proximity to volatile compounds within the device. Failures have occurred during both use and storage of the devices or their components. The subsequent injuries from several of these events, including full thickness burns requiring grafting and blast injuries, have been observed at Arrowhead Regional Medical Center, a regional trauma and burn center in southern California...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27818882/microbial-activities-in-soil-cultivated-with-corn-and-amended-with-sewage-sludge
#8
Rosana Faria Vieira, Ricardo Antônio Almeida Pazianotto
BACKGROUND: One of the main concerns related to the increasing use of sewage sludge in the soil is the possible presence of excess nutrients, which could cause environmental problems and detrimental effects on the soil microorganisms, considered essential to soil nutrient cycling. Thus, the objective of this work was to evaluate the microbial biomass and activity and some chemical characteristics of one specific tropical soil, classified as Dark Red Distroferric Latosol, of a loamy/clayey texture, in a long-term field experiment using anaerobically digested household sludge amendment...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27818322/an-overview-of-herb-and-dietary-supplement-efficacy-safety-and-government-regulations-in-the-united-states-with-suggested-improvements-part-1-of-5-series
#9
REVIEW
Amy Christine Brown
This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (herbs; 20%), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs and zero deaths due to DS...
November 3, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27807095/when-drug-trials-are-halted
#10
(no author information available yet)
When significant safety questions arise during a trial, the FDA has the option to place a full or partial clinical hold on treatment and new enrollment. Clinical holds are designed to protect patients from serious harm but they can also cause expensive delays for drug developers and frustrations for patients. While some problems can be resolved quickly, others can permanently derail a drug's development.
November 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27795450/marine-derived-pharmaceuticals-challenges-and-opportunities
#11
REVIEW
Ulrike Lindequist
Marine biosphere is the largest one of the earth and harbors an enormous number of different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production of specific secondary metabolites is an important adaption mechanism of marine organisms to survive in the sea. These metabolites possess biological activities which make them interesting as possible drugs for human. The review presents sources, chemistry, production and pharmacology of FDA approved marine derived pharmaceuticals arranged according to their therapeutic indication...
November 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27766937/leveraging-graph-topology-and-semantic-context-for-pharmacovigilance-through-twitter-streams
#12
Ryan Eshleman, Rahul Singh
BACKGROUND: Adverse drug events (ADEs) constitute one of the leading causes of post-therapeutic death and their identification constitutes an important challenge of modern precision medicine. Unfortunately, the onset and effects of ADEs are often underreported complicating timely intervention. At over 500 million posts per day, Twitter is a commonly used social media platform. The ubiquity of day-to-day personal information exchange on Twitter makes it a promising target for data mining for ADE identification and intervention...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27738557/bacteriophages-safely-reduce-salmonella-contamination-in-pet-food-and-raw-pet-food-ingredients
#13
Nitzan Soffer, Tamar Abuladze, Joelle Woolston, Manrong Li, Leigh Farris Hanna, Serena Heyse, Duane Charbonneau, Alexander Sulakvelidze
Contamination of pet food with Salmonella is a serious public health concern, and several disease outbreaks have recently occurred due to human exposure to Salmonella tainted pet food. The problem is especially challenging for raw pet foods (which include raw meats, seafood, fruits, and vegetables). These foods are becoming increasingly popular because of their nutritional qualities, but they are also more difficult to maintain Salmonella-free because they lack heat-treatment. Among various methods examined to improve the safety of pet foods (including raw pet food), one intriguing approach is to use bacteriophages to specifically kill Salmonella serotypes...
July 2016: Bacteriophage
https://www.readbyqxmd.com/read/27717287/cocaine-vaccine-development-evaluation-of-carrier-and-adjuvant-combinations-that-activate-multiple-toll-like-receptors
#14
Atsushi Kimishima, Cody J Wenthur, Lisa M Eubanks, Shun Sato, Kim D Janda
Although cocaine abuse and addiction continue to cause serious health and societal problems, an FDA-approved medication to treat cocaine addiction has yet to be developed. Employing a pharmacokinetic strategy, an anti-cocaine vaccine, provides an attractive avenue to address these issues, however, current vaccines have shown varying degrees of efficacy, indicating that further formulation is necessary. As a means to improve vaccine efficacy, we examined the effects of varying anti-cocaine vaccine formulations by combining a Toll-like receptor 9 (TLR9) agonist with a TLR5 agonist in the presence of alum...
October 7, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27716673/the-utilization-of-robotic-pets-in-dementia-care
#15
Sandra Petersen, Susan Houston, Huanying Qin, Corey Tague, Jill Studley
BACKGROUND: Behavioral problems may affect individuals with dementia, increasing the cost and burden of care. Pet therapy has been known to be emotionally beneficial for many years. Robotic pets have been shown to have similar positive effects without the negative aspects of traditional pets. Robotic pet therapy offers an alternative to traditional pet therapy. OBJECTIVE: The study rigorously assesses the effectiveness of the PARO robotic pet, an FDA approved biofeedback device, in treating dementia-related symptoms...
October 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27707005/genotoxicity-of-antiobesity-drug-orlistat-and-effect-of-caffeine-intervention-an-in-vitro-study
#16
Manoswini Chakrabarti, Ilika Ghosh, Aditi Jana, Manosij Ghosh, Anita Mukherjee
CONTEXT: Obesity is a major global health problem associated with various adverse effects. Pharmacological interventions are often necessary for the management of obesity. Orlistat is an FDA-approved antiobesity drug which is a potent inhibitor of intestinal lipases. OBJECTIVE: In the current study, orlistat was evaluated for its genotoxic potential in human lymphocyte cells in vitro and was compared with that of another antiobesity drug sibutramine, presently withdrawn from market due its undesirable health effects...
October 6, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27706433/-overview-of-regulatory-aspects-guiding-tablet-scoring
#17
Maíra Teles Teixeira, Lívia Cristina Lira Sá-Barreto, Dayde Lane Mendonça Silva, Marcílio Sergio Soares Cunha-Filho
Tablet scoring is a controversial but common practice used to adjust doses, facilitate drug intake, or lower the cost of drug treatment, especially in children and the elderly. The risks of tablet scoring are mainly related to inaccuracies in the resulting dose and stability problems. The aim of this article is to provide an overview of worldwide guidelines regarding tablet scoring. We found that regulatory health agencies in Mercosur countries as well as other South American countries do not have published standards addressing tablet splitting...
June 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27694680/correcting-india-s-chronic-shortage-of-drug-inspectors-to-ensure-the-production-and-distribution-of-safe-high-quality-medicines
#18
Abhay B Kadam, Karen Maigetter, Roger Jeffery, Nerges F Mistry, Mitchell G Weiss, Allyson M Pollock
BACKGROUND: Good drug regulation requires an effective system for monitoring and inspection of manufacturing and sales units. In India, despite widespread agreement on this principle, ongoing shortages of drug inspectors have been identified by national committees since 1975. The growth of India's pharmaceutical industry and its large export market makes the problem more acute. METHODS: The focus of this study is a case study of Maharashtra, which has 29% of India's manufacturing units and 38% of its medicines exports...
April 27, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27682876/overcoming-adaptive-resistance-in-mucoepidermoid-carcinoma-through-inhibition-of-the-ikk-%C3%AE-i%C3%AE%C2%BAb%C3%AE-nf%C3%AE%C2%BAb-axis
#19
Vivian P Wagner, Marco A T Martins, Manoela D Martins, Kristy A Warner, Liana P Webber, Cristiane H Squarize, Jacques E Nör, Rogerio M Castilho
Patients with mucoepidermoid carcinoma (MEC) experience low survival rates and high morbidity following treatment, yet the intrinsic resistance of MEC cells to ionizing radiation (IR) and the mechanisms underlying acquired resistance remain unexplored. Herein, we demonstrated that low doses of IR intrinsically activated NFκB in resistant MEC cell lines. Moreover, resistance was significantly enhanced in IR-sensitive cell lines when NFκB pathway was stimulated. Pharmacological inhibition of the IKK-β/IκBα/NFκB axis, using a single dose of FDA-approved Emetine, led to a striking sensitization of MEC cells to IR and a reduction in cancer stem cells...
September 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27670346/synthetic-and-natural-nutritional-supplements-health-allies-or-risk-to-public-health
#20
Nassia Kioukia-Fougia, Nikolaos Georgiadis, Konstantinos Tsarouhas, Fotini Vasilaki, Persefoni Fragkiadaki, Evangelia Meimeti, Christina Tsitsimpikou
BACKGROUND: The modern way of life involves high stress levels, poor eating habits, lack of exercise, obesity and other detrimental health factors. Nutritional supplements (NS) are complexes of nutrients with variant activity that may infer reversal to nutrient depletion. They tend to be popular amongst social categories associated with the healthy life style, such as the elite and amateur athletes, military people and the general population. OBJECTIVE: An overview of the state of play with regards to nutritional supplements -natural and synthetic-, is important both from toxicological and commercial point of view...
September 23, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
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