Derrick Wan, Heather Talbott, Michelle Griffin, Shamik Mascharak, Jennifer Parker, Maxwell Kuhnert, Jason Guo, Nestor Diaz Deleon, Christopher Lavin, Darren Abbas, Nicholas Guardino, Annah Morgan, Caleb Valencia, Asha Cotterell, Michael Longaker
Skin fibrosis is a clinical problem with devastating impacts but limited treatment options. In the setting of diabetes, insulin administration often causes local dermal fibrosis, leading to a range of clinical sequelae including impeded insulin absorption. Mechanical forces are important drivers of fibrosis and, clinically, physical tension offloading at the skin level using an elastomeric patch significantly reduces wound scarring. However, it is not known whether tension offloading could similarly prevent skin fibrosis in the setting of pro-fibrotic injections...
March 1, 2024: Research Square