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Opiate testing

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https://www.readbyqxmd.com/read/29658501/-anhedonia-depression-anxiety-and-craving-in-opioid-dependent-patients-stabilized-on-oral-naltrexone-or-naltrexone-implant
#1
E M Krupitsky, E E Zvartau, E A Blokhina, E V Verbitskaya, V Yu Wahlgren, M V Tsoy-Podosenin, N M Bushara, A M Burakov, D V Masalov, T N Romanova, A A Tiurina, V Ya Palatkin, T S Yaroslavtseva, G Yu Sulimov, A Pecoraro, G Woody
AIM: To assess the relationship between long-term naltrexone treatment and anxiety, depression and craving in opioid dependent individuals. MATERIAL AND METHODS: Opioid dependent patients (n=306) were enrolled in a three cell (102ss/cell) randomized, double blind, double dummy, placebo-controlled 6-month trial comparing extended release implantable naltrexone with oral naltrexone and placebo (oral and implant). Monthly assessments of affective responses used a Visual Analog Scale for opioid craving, the Beck Depression Inventory, Spielberger Anxiety Inventory, and the Ferguson and Chapman Anhedonia Scales...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29626673/assessment-of-gonadotropins-and-testosterone-hormone-levels-in-regular-mitragyna-speciosa-korth-users
#2
Darshan Singh, Vikneswaran Murugaiyah, Shahrul Bariyah Sahul Hamid, Vicknasingam Kasinather, Michelle Su Ann Chan, Eric Tatt Wei Ho, Oliver Grundmann, Nelson Jeng Yeou Chear, Sharif Mahsufi Mansor
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels. AIM OF THE STUDY: Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29618930/symptoms-associated-with-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorders-in-school-aged-children-prenatally-exposed-to-substances
#3
Lisbeth Beate Sandtorv, Silje Katrine Elgen Fevang, Sondre Aasen Nilsen, Tormod Bøe, Rolf Gjestad, Siren Haugland, Irene Bircow Elgen
Prenatal exposure to substances may influence a child's neurodevelopment and impact on subsequent mental health. In a hospital-based population of school-aged children prenatally exposed to opiates and a number of illicit substances (n = 57), we evaluated mental health symptoms associated with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) using the Swanson, Nolan, and Pelham Questionnaire, revision IV (SNAP-IV) and the Autism Spectrum Screening Questionnaire (ASSQ) and compared the scores to a reference group which comprised children from the population-based Bergen Child Study (n = 171)...
2018: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/29601219/an-examination-of-the-perceived-impact-of-a-continuing-interprofessional-education-experience-on-opiate-prescribing-practices
#4
Roberto Cardarelli, William Elder, Sarah Weatherford, Karen L Roper, Dana King, Charlotte Workman, Kathryn Stewart, Chong Kim, William Betz
Chronic pain is increasingly recognized as a public health problem. We assessed the effectiveness of a multi-modal, interprofessional educational approach aimed at empowering healthcare professionals to make deliberative changes, especially in opiate prescribing practices. Education activities included enduring webcasts, regional interprofessional roundtable events, and state-level conference presentations within targeted Kentucky and West Virginia regions of the United States. Over 1,000 participants accessed the various activities...
March 30, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29594216/a-predictive-model-for-residual-disease-after-chemo-radiotherapy-in-oropharyngeal-carcinoma-combined-radiological-and-clinical-evaluation-of-tumor-response
#5
Zeno A R Gouw, Bas Jasperse, Jan-Jakob Sonke, Wilma D Heemsbergen, Arash Navran, Olga Hamming-Vrieze, Jan Paul de Boer, Michiel W M van den Brekel, Abrahim Al-Mamgani
Background and purpose: Early detection of Residual disease (RD) is vital for salvage possibilities after (chemo) radiatiotherapy for oropharyngeal carcinoma (OPC). We standardized clinical investigation to test its added value to MRI response evaluation and investigated the benefit of FDG-PET/CT. Materials and methods: Radiological response evaluation using Ojiri-score was done for 234 patients with OPC, using MRI 12 weeks after (chemo) radiotherapy between 2010 and 2014...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29578352/prospective-study-of-the-factors-associated-with-poor-tolerance-to-ambulatory-colonoscopy-under-conscious-sedation
#6
Israel Grilo-Bensusan, Pablo Herrera Martín, Remedios Jiménez-Mesa, Valle Aguado Álvarez
BACKGROUND: conscious sedation with benzodiazepines and opiates for colonoscopy is a widespread clinical practice. OBJECTIVE: to determine the patient's tolerance to colonoscopy and identify the factors associated with lower tolerance. METHODS: a prospective, single-center, descriptive study of patients undergoing ambulatory colonoscopy under conscious sedation. The pain was assessed using a visual analogue scale with a score of 0 to 100 and also qualitatively...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29574346/evaluation-of-three-rapid-oral-fluid-test-devices-on-the-screening-of-multiple-drugs-of-abuse-including-ketamine
#7
Magdalene H Y Tang, C K Ching, Simon Poon, Suzanne S S Chan, W Y Ng, M Lam, C K Wong, Ronnie Pao, Angus Lau, Tony W L Mak
Rapid oral fluid testing (ROFT) devices have been extensively evaluated for their ability to detect common drugs of abuse; however, the performance of such devices on simultaneous screening for ketamine has been scarcely investigated. The present study evaluated three ROFT devices (DrugWipe® 6S, Ora-Check® and SalivaScreen® ) on the detection of ketamine, opiates, methamphetamine, cannabis, cocaine and MDMA. A liquid chromatography tandem mass spectrometry (LCMS) assay was firstly established and validated for confirmation analysis of the six types of drugs and/or their metabolites...
March 12, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29569175/cervical-dystonia-and-substance-abuse
#8
Abhimanyu Mahajan, Joseph Jankovic, Laura Marsh, Achint Patel, H A Jinnah, Cynthia Comella, Richard Barbano, Joel Perlmutter, Neepa Patel
OBJECTIVE: To investigate the prevalence of substance abuse (SA) in patients with cervical dystonia (CD) and to correlate it with prevalence of psychiatric disorders. METHODS: Data on anxiety, depression, dystonia severity, and substance abuse were collected from ten sites participating in the Dystonia Coalition. Patients were divided into two groups according to the presence of SA, utilizing Structured Clinical Interview for DSM-4 criteria. Wilcoxon Rank-Sum test was used to analyze the difference in median scores on the questionnaires between the groups...
March 22, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29564682/opioid-exposure-is-associated-with-aberrant-dna-methylation-of-oprm1-promoter-region-in-a-chinese-han-population
#9
Jiawei Xu, Teng Wang, Zhiyang Su, Xinyao Zhou, Yuqian Xiang, Lin He, Candong Li, Zhaoyang Yang, Xinzhi Zhao
The μ-opioid receptor (OPRM1) plays an important role in opiate addiction. The OPRM1 gene promoter showed hypermethylation in lymphocytes of opiate addicts as well as opioid medications users, while the methylation status displayed ethnic diversity. The purpose of the study was to investigate the methylation pattern of OPRM1 promoter in the Han Chinese population. We analyzed 22 CpG sites located in OPRM1 promoter in 186 former opiate addicts (94 males and 92 females) and 184 healthy controls (102 males and 82 females)...
March 21, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29560840/older-women-who-died-by-suicide-suicide-means-sociodemographic-and-psychiatric-risk-factors-and-other-precipitating-circumstances
#10
Namkee G Choi, Diana M DiNitto, Atami O Sagna, C Nathan Marti
BACKGROUND: US suicide rates among older women have substantially increased over the past decade. We examined potential differences in sociodemographic and risk/precipitating factors among older female suicide decedents who died by drug overdose versus firearms, hanging/suffocation, and other means, and postmortem toxicology results by suicide means. METHODS: Data are from the 2005 to 2015 US National Violent Death Reporting System (N = 12,401 female decedents aged 50 years and over)...
March 21, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29543652/exposure-to-opiates-in-male-adolescent-rats-alters-pain-perception-in-the-male-offspring
#11
Narges Pachenari, Hossein Azizi, Elmira Ghasemi, Maryam Azadi, Saeed Semnanian
During the past decades, the use/misuse of opioids has increased dramatically among adolescent population. It is now well acknowledged that various morphological and physiological changes occur in the brain during adolescence. During this critical period, brain development and maturation could be affected by several factors including stress, drug abuse, nutritional status, etc. Although studies on transgenerational effects of substances such as alcohol, nicotine, and cocaine have focused on both paternal and maternal drug exposure, most reports on transgenerational effects of morphine are restricted to maternal exposure...
April 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29541774/the-role-of-aging-drug-dependence-and-hepatitis-c-comorbidity-in-alcoholism-cortical-compromise
#12
Edith V Sullivan, Natalie M Zahr, Stephanie A Sassoon, Wesley K Thompson, Dongjin Kwon, Kilian M Pohl, Adolf Pfefferbaum
Importance: The prevalence of alcohol misuse increased substantially over a decade in adults, particularly in those aged 65 years or older. Ramifications for brain structural integrity are significant, especially in older adults. Objectives: To combine cross-sectional, longitudinal data to test age-alcoholism interactions and examine the association between prevalent comorbidities (drug dependence and hepatitis C virus [HCV] infection) and cortical volume deficits in alcohol dependence...
March 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29533847/the-additive-effects-of-depressive-symptoms-and-polysubstance-use-on-hiv-risk-among-gay-bisexual-and-other-men-who-have-sex-with-men
#13
Kiffer G Card, Nathan J Lachowsky, Heather L Armstrong, Zishan Cui, Lu Wang, Paul Sereda, Jody Jollimore, Thomas L Patterson, Trevor Corneil, Robert S Hogg, Eric A Roth, David M Moore
INTRODUCTION: Among gay, bisexual, and other men who have sex with men (GBM), collinearity between polysubstance use and mental health concerns has obscured their combined effects on HIV risk with multivariable results often highlighting only one or the other. METHODS: We used mediation and moderation analyses to examine the effects of polysubstance use and depressive symptoms on high-risk sex (i.e., condomless anal sex with serodiscordant/unknown status partner) in a sample of sexually-active GBM, aged ≥16 years, recruited in Metro Vancouver using respondent driven sampling...
March 6, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29513114/antinociceptive-potency-of-a-fluorinated-cyclopeptide-dmt-c-d-lys-phe-p-cf-3-phe-asp-nh-2
#14
Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka
Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor. However, delta- and kappa-opioid receptors can also contribute to the analgesic effects of opioids. Recent findings showed that simultaneous activation of multiple opioid receptors may result in additional analgesia with fewer side effects. Here, we evaluated the pharmacological profile of our formerly developed mixed mu/kappa-opioid receptor ligands, Dmt-c[D-Lys-Phe-Phe-Asp]NH2 (C-36) and Dmt-c[D-Lys-Phe-p-CF3 -Phe-Asp]NH2 (F-81)...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29508893/correlates-of-opiate-misuse-based-on-aberrant-urine-drug-tests-for-patients-on-chronic-opiate-therapy-in-a-safety-net-academic-primary-care-clinic
#15
Smita Bakhai, Bright Thilagar, Jessica L Reynolds, Kenneth E Leonard
OBJECTIVE: Determine correlates of opiate misuse based on urine drug test (UDT) among patients on chronic opiate therapy (COT) for chronic noncancer pain. DESIGN: A cross-sectional study. SETTING: Urban, academic clinic. PARTICIPANTS: UDT performed in 206 patients on COT for at least 3 months duration within a one-year period. Patients were classified based on UDT results: (1) Appearance of Opiate Adherence: Positive UDT for prescribed opiate and negative for illicit drugs and nonprescribed control substances; (2) Opiate Misuse; Overt nonadherence: (a) Positive UDT for illicit drugs and/or nonprescribed controlled substances AND positive or negative for prescribed opiates (b) Overdose; (3) Possible opiate nonadherence: Negative for prescribed opiates and negative for illicit and nonprescribed controlled substances...
January 2018: Journal of Opioid Management
https://www.readbyqxmd.com/read/29454709/in-vitro-diagnosis-of-immediate-drug-hypersensitivity-during-anesthesia-a-review-of-the-literature
#16
Didier G Ebo, Margaretha Faber, Jessy Elst, Athina L Van Gasse, Chris H Bridts, Christel Mertens, Luc S De Clerck, Margo M Hagendorens, Vito Sabato
Quantification of specific IgE (sIgE) antibodies constitutes an important measure to document anesthesia-related immediate hypersensitivity reactions (IHRs). However, only a few drug-specific assays are available and their predictive value is not known. In cases of non-IgE mediated IHRs, diagnosis might benefit from cellular tests such as basophil mediator release tests and basophil activation tests (BATs). To review the potential and limitations of quantification of sIgE, mediator release, and BAT in anesthesia-related IHRs, a literature search was conducted using the key words allergy, basophil activation, CD63, CD203c, diagnosis, drugs, hypersensitivity, flow cytometry, MRGPRX2, specific IgE antibodies, leukotrienes, histamine, and tryptase; this was complemented by the authors' experience...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29453495/comparison-of-concentrations-of-drugs-between-blood-samples-with-and-without-fluoride-additive-important-findings-for-%C3%AE-9-tetrahydrocannabinol-and-amphetamine
#17
Christopher Wiedfeld, Julia Krueger, Gisela Skopp, Frank Musshoff
Fluoride is a common stabilizing agent in forensic toxicology to avoid the frequent problem of degradation of drugs in blood samples especially described for cocaine. In cases only samples with addition of fluoride are available, it is a crucial question if also concentrations of common drugs other than cocaine (amphetamines, opiates and cannabinoids) are affected by fluoride. So far, there are only rare literature data available on discrepant results especially for Δ 9 -tetrahydrocannabinol (THC). In this study, comparative analysis of positive tested paired routine plasma/serum samples (n = 375), collected at the same time point (one device with and one without fluoride), was carried out with special focus on cannabinoids...
February 17, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29428641/interpreting-interaction-effects-in-estimates-of-the-risk-of-traffic-injury-associated-with-the-use-of-illicit-drugs
#18
Rune Elvik
Interactions characterise the relationship between use of amphetamines, cannabis and opiates as a driver and the risk of traffic injury associated with the use of these drugs. Inverse risk curves have been found for these drugs, meaning that the higher the proportion of drivers in normal traffic testing positive for the drugs, the lower is the increase in risk associated with them. The inverse risk curves can arise in many ways. The paper discusses ten different interpretations of the curves; seven of these are methodological and claim that the risk curves are statistical artefacts...
April 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29419341/comparing-the-validity-of-self-report-and-urinalysis-for-substance-use-among-former-inmates-in-the-northeastern-united-states
#19
Jacob J van den Berg, Samuel Adeyemo, Mary B Roberts, Beth C Bock, L A R Stein, Rosemarie A Martin, Donna R Parker, Jennifer G Clarke
BACKGROUND: Problems with self-reported drug use include difficulties with recall and recognition as well as the desire to respond to questions in a socially desirable manner. Various methods have been developed to improve and/or validate estimates based on direct questioning of individuals regarding their substance use. For this study, we were interested in validating self-reported use of: 1) tobacco, 2) marijuana, and 3) other substances (i.e., heroin, cocaine, opiates, oxycodone, benzodiazepines, methamphetamine, phencyclidine, and barbiturates) employing urinalysis among inmates who participated in a randomized controlled trial of a smoking abstinence intervention in a tobacco-free prison located in the northeastern United States...
February 8, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29409046/evaluation-of-dr%C3%A3-ger-drugtest-5000-in-a-naturalistic-setting
#20
Hallvard Gjerde, Grethe Brennhovd Clausen, Espen Andreassen, Håvard Furuhaugen
Reliable field testing devices for psychoactive drugs would be useful tools for the police for detecting drug-impaired drivers. The Norwegian Mobile Police Service (NMPS) started using Dräger DrugTest 5000 (DDT5000) in 2015 as an on-site screening instrument for drugs in samples of oral fluid. The aim of this study was to compare the results of field testing of DDT5000 with drug findings in blood and oral fluid samples taken from drivers suspected for driving under the influence of drugs (DUID). In total, 369 drivers were included in this field testing; blood samples were obtained from all of them, while oral fluid samples were collected with the Intercept device from 301 of them...
February 2, 2018: Journal of Analytical Toxicology
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