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https://www.readbyqxmd.com/read/29331129/perspective-structural-fluctuation-of-protein-and-anfinsen-s-thermodynamic-hypothesis
#1
Fumio Hirata, Masatake Sugita, Masasuke Yoshida, Kazuyuki Akasaka
The thermodynamics hypothesis, casually referred to as "Anfinsen's dogma," is described theoretically in terms of a concept of the structural fluctuation of protein or the first moment (average structure) and the second moment (variance and covariance) of the structural distribution. The new theoretical concept views the unfolding and refolding processes of protein as a shift of the structural distribution induced by a thermodynamic perturbation, with the variance-covariance matrix varying. Based on the theoretical concept, a method to characterize the mechanism of folding (or unfolding) is proposed...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330646/potential-impact-of-sglt2-inhibitors-on-left-ventricular-diastolic-function-in-patients-with-diabetes-mellitus
#2
REVIEW
Hidekazu Tanaka, Ken-Ichi Hirata
The pathogenesis of diabetes mellitus (DM)-related cardiac dysfunction is thought to be multifactorial, and possibly a key factor for the development of heart failure with preserved ejection fraction (HFpEF) in patients with DM and preserved left ventricular (LV) ejection fraction. Currently, there is no effective treatment for HFpEF, which is presented as LV diastolic dysfunction. Furthermore, it is well known that, in addition to DM, hypertension and overweight/obesity are also important factors associated with HFpEF...
January 12, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29325884/experimental-low-back-pain-decreased-trunk-muscle-activity-in-currently-asymptomatic-recurrent-low-back-pain-patients-during-step-tasks
#3
Lars Henrik Larsen, Rogerio Pessoto Hirata, Thomas Graven-Nielsen
Low back pain (LBP) patients demonstrate reorganized trunk muscle activity but if similar changes are manifest in recurrent LBP patients (R-LBP) during asymptomatic periods remains unknown. In 26 healthy and 27 currently asymptomatic R-LBP participants electromyographic activity (EMG) was recorded from trunk and gluteal muscles during series of stepping up and down on a step bench before and during experimentally intramuscular induced unilateral and bilateral LBP. Pain intensity was assessed by numeric rating scale (NRS) scores...
January 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29325472/latent-psychological-distress-existing-behind-a-set-of-assessment-measures-is-comparable-to-or-more-important-than-symptoms-or-disability-in-the-association-with-quality-of-life-and-working-status-of-patients-with-rheumatoid-arthritis
#4
Akie Hirata, Tomoya Miyamura, Yasuo Suenaga, Masao Katayama, Eiichi Suematsu, Shigeto Tohma
OBJECTIVES: To identify the determinant of patients' perspectives of quality of life (QOL) and working status out of analysis-derived components underlying a set of assessment measures of the status of patients with rheumatoid arthritis (RA). METHODS: From the NinJa database in Japan (2012-2014), 1455 RA patients with DAS28 >3.2 were recruited. Components explaining RA status were derived from principal component analysis of 15 assessment measures. Multivariate regression was used to examine the relative contribution of each identified component to the EuroQOL-5 Dimension Questionnaire score and working status...
January 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29321587/distribution-analysis-of-epertinib-in-brain-metastasis-of-her2-positive-breast-cancer-by-imaging-mass-spectrometry-and-prospect-for-antitumor-activity
#5
Yukari Tanaka, Michinari Hirata, Satomi Shinonome, Mikinori Torii, Ken-Ichi Nezasa, Hidekazu Tanaka
Epertinib (S-222611) is a potent, reversible, and selective tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), human EGFR2 (HER2), and human EGFR4. We developed experimental brain metastasis models by intraventricular injection (intraventricular injection mouse model; IVM) of HER2-positive breast cancer (MDA-MB-361-luc-BR2/BR3) or T790M-EGFR-positive lung cancer (NCI-H1975-luc) cells. After a single oral administration, epertinib and lapatinib concentrations in brain metastatic regions were analyzed by quantitative imaging mass spectrometry...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321412/the-successful-treatment-of-sodium-polystyrene-sulfonate-induced-enteritis-diagnosed-by-small-bowel-endoscopy
#6
Kohei Okayama, Yoshikazu Hirata, Daisuke Kumai, Yuki Yamamoto, Yuki Kojima, Takuya Kanno, Hirokazu Ikeuchi, Hisato Mochizuki, Hiroki Takada, Satoshi Sobue
Sodium polystyrene sulfonate (SPS: Kayexalate®) is an ion-exchange resin used to treat hyperkalemia in patients with chronic kidney disease. It is known that this resin sometimes causes colonic necrosis and perforation, but there are few reports about small bowel necrosis associated with SPS. We herein report the case of a patient who developed SPS-induced small bowel necrosis, which was diagnosed based on the examination of a small bowel endoscopic biopsy specimen. The SPS-induced small bowel necrosis was resistant to conservative treatment including the cessation of SPS, and finally required surgical bowel resection...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321405/reversible-parkinsonism-and-multiple-cerebral-infarctions-after-pulmonary-endarterectomy-in-a-patient-with-antiphospholipid-syndrome
#7
Mitsumasa Okano, Kazuhiko Nakayama, Naoki Tamada, Yuto Shinkura, Ken-Ichi Yanaka, Hiroyuki Onishi, Hidekazu Tanaka, Toshiro Shinke, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Ken-Ichi Hirata
Antiphospholipid syndrome (APS) is a cause of chronic thromboembolic pulmonary hypertension (CTEPH) and it is associated with an increased risk of postoperative neurological complications. We experienced a case of reversible parkinsonism after pulmonary endarterectomy (PEA) and subsequent multiple cerebral infarctions under standard anticoagulation therapy in a patient with CTEPH associated with APS. Strict management using a combination of antiplatelet and anticoagulation therapy should be considered in patients with a high titer of triple antiphospholipid antibodies in the perioperative period...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29320764/usefulness-of-mean-corpuscular-volume-for-detection-of-advanced-colorectal-cancer-in-patients-older-than-85-years
#8
Motohiko Kato, Yoko Kubosawa, Yuichiro Hiarai, Keiichiro Abe, Tetsu Hirata, Yoshiaki Takada, Michiko Wada, Yusaku Takatori, Satoshi Kinoshita, Kaoru Takabayashi, Masahiro Kikuchi, Takashi Ohishi, Toshio Uraoka
BACKGROUND/AIMS: The aim of this study was to elucidate clinical indicators for the detection of advanced colorectal cancer (ACRC). METHODS: This was a retrospective study conducted at a tertiary hospital. This study included 333 patients older than 85 years who underwent colonoscopy from April 2006 to May 2010. The detection rate of ACRC was assessed. Then, we analyzed the association between the detection of ACRC and various background factors including mean corpuscular volume (MCV)...
January 10, 2018: Digestion
https://www.readbyqxmd.com/read/29319344/clinical-performance-metrics-of-3d-stereoscopic-digital-mammography-compared-with-2d-digital-mammography-observer-study
#9
Akiko Daidoji, Takatoshi Aoki, Seiichi Murakami, Mari Miyata, Masami Fujii, Takefumi Katsuki, Yuzuru Inoue, Yuko Tashima, Yoshika Nagata, Keiji Hirata, Fumihiro Tanaka, Yukunori Korogi
OBJECTIVE: To assess the clinical performance of three-dimensional stereoscopic digital mammography (3DsDM) compared with two-dimensional digital mammography (2DDM) for breast lesion diagnosis with jackknife free-response receiver operating characteristics (JAFROC) observer study. METHODS: Forty pairs of standard-dose 2DDM and their 3DsDM images were used for an observer performance study. A total of 18 lesions were identified as the reference standard of actionable breast lesions (BI-RADS category 3 or more) by 2 breast radiologists...
January 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29316331/light-sheet-microscopy-and-sral2-o4-nanoparticles-co-doped-with-eu2-dy3-ions-for-cancer-cell-tagging
#10
B Can-Uc, J B Montes-Frausto, K Juarez-Moreno, J Licea-Rodriguez, I Rocha-Mendoza, G A Hirata
Light sheet optical microscopy on strontium aluminate nanoparticles (SrAl2 O4 NPs) co-doped with Eu2+ and Dy3+ were used for cancer cell tagging and tracking. The nanoparticles were synthesized by urea-assisted combustion with optimized percentage values of the two co-doping rare-earth ions for cell viability and for lower cytotoxic effects. The optical properties of these materials showed an excitation wide range of wavelengths (λexc = 254 ~ 460 nm), a broad emission band (λem = 475 ~ 575 nm) with the maximum centered wavelength at 525 nm and a half lifetime within the seconds regime...
January 9, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29313813/a-phase-ii-study-of-trastuzumab-emtansine-in-her2-positive-non-small-cell-lung-cancer
#11
Katsuyuki Hotta, Keisuke Aoe, Toshiyuki Kozuki, Kadoaki Ohashi, Kiichiro Ninomiya, Eiki Ichihara, Toshio Kubo, Takashi Ninomiya, Kenichi Chikamori, Daijiro Harada, Naoyuki Nogami, Taizo Hirata, Shiro Hinotsu, Shinichi Toyooka, Katsuyuki Kiura
Trastuzumab emtansine (T-DM1), an anti-HER2 antibody-drug conjugate, has been shown to significantly improve survival in HER2-positive breast cancer. We report a phase II trial of T-DM1 monotherapy in relapsed non-small-cell lung cancer (NSCLC). with documented HER2-positivity (immunohistochemistry [IHC] 3+, both IHC 2+ and fluorescence in situ hybridization [FISH] +, or exon 20 mutation). This study was terminated early due to limited efficacy. The demographic characteristics in the 15 assessable patients were as follows: age (median: 67 years), sex (male: 47%), performance status (0-1: 80%), and HER2 status (IHC 3+: 33%; IHC 2+/FISH: 20%; mutation: 47%)...
December 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29310661/temperature-elevation-in-the-human-brain-and-skin-with-thermoregulation-during-exposure-to-rf-energy
#12
Sachiko Kodera, Jose Gomez-Tames, Akimasa Hirata
BACKGROUND: Two international guidelines/standards for human protection from electromagnetic fields define the specific absorption rate (SAR) averaged over 10 g of tissue as a metric for protection against localized radio frequency field exposure due to portable devices operating below 3-10 GHz. Temperature elevation is suggested to be a dominant effect for exposure at frequencies higher than 100 kHz. No previous studies have evaluated temperature elevation in the human head for local exposure considering thermoregulation...
January 8, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29307044/transcatheter-closure-for-residual-atrial-septal-defect-resulting-from-surgical-patch-closure-44%C3%A2-years-previously
#13
Hiroki Matsuzoe, Hidekazu Tanaka, Keiko Hatazawa, Yutaka Hatani, Kensuke Matsumoto, Toshiro Shinke, Ken-Ichi Hirata
No abstract text is available yet for this article.
January 6, 2018: Journal of Echocardiography
https://www.readbyqxmd.com/read/29302869/lanthanum-induced-mucosal-alterations-in-the-stomach-lanthanum-gastropathy-a-comparative-study-using-an-animal-model
#14
Kei Yabuki, Joji Haratake, Yojiro Tsuda, Eisuke Shiba, Hiroshi Harada, Kenji Yorita, Kazuyoshi Uchihashi, Atsuji Matsuyama, Keiji Hirata, Masanori Hisaoka
Lanthanum (La) carbonate (LC) is one of the most potent phosphate binders that prevents the elevation of serum phosphate levels in patients with end-stage renal diseases undergoing dialysis. LC binds strongly to dietary phosphate and forms insoluble complexes that pass through the gastrointestinal tract. La deposition in patients treated with LC is a recently documented finding particularly observed in gastric mucosa. We herein describe the detailed gastric mucosal lesions in 45 LC-treated patients and address the potential underlying pathologic mechanism using oral LC administration in rats...
January 4, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29299115/extracellular-mir-224-as-a-prognostic-marker-for-clear-cell-renal-cell-carcinoma
#15
Nakanori Fujii, Hiroshi Hirata, Koji Ueno, Junichi Mori, Shintaro Oka, Kosuke Shimizu, Yoshihisa Kawai, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Tomoyuki Shimabukuro, Koichi Udoh, Yoshinobu Hoshii, Rajvir Dahiya, Hideyasu Matsuyama
Exosome-miRNAs (exo-miR) have recently been identified as modulators of cancer progression and distant metastasis. We previously found that intracellular miR-224 is up-regulated and significantly related to cancer invasion and metastasis in clear cell renal cell carcinoma (ccRCC). We therefore investigated the role of exosome miR-224 in ccRCC and explored the interaction between intra- and extracellular miR-224 in renal cell carcinoma. To validate the method for isolating exosomes from blood samples or cell culture media, we examined exosome morphology using transmission electron microscope (TEM)...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297380/recognition-of-and-care-seeking-for-maternal-and-newborn-complications-in-jayawijaya-district-papua-province-indonesia-a-qualitative-study
#16
Alfonso Rosales, Sigit Sulistyo, Oktarinda Miko, Lila K Hairani, Meita Ilyana, Joanne Thomas, Emily Hirata, Rhonda Holloway, Michael Bantung, Kristina Pabate, Candra Wijaya, Dennis Cherian
BACKGROUND: Indonesia's progress on reducing maternal and newborn mortality rates has slowed in recent years, predominantly in rural areas. To reduce maternal and newborn mortality, access to quality and skilled care, particularly at the facility level, is crucial. Yet, accessing such care is often delayed when maternal and newborn complications arise. Using the "Three Delays" model originated by Thaddeus and Maine (1994), investigation into reasons for delaying the decision to seek care, delaying arrival at a health facility, and delaying the receiving of adequate care, may help in establishing more focused interventions to improve maternal and newborn health in this region...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29289935/association-between-total-dose-of-ritodrine-hydrochloride-and-pulmonary-oedema-in-twin-pregnancy-a-retrospective-cohort-study-in-japan
#17
Satoshi Shinohara, Rei Sunami, Yuzo Uchida, Shuji Hirata, Kohta Suzuki
OBJECTIVE: Pulmonary oedema is recognised as a severe side effect of ritodrine hydrochloride. Recently, the number of twin pregnancies has been increasing. Few studies have reported the association between total dose of ritodrine hydrochloride prior to delivery and pulmonary oedema in twin pregnancy. We aimed to examine this association and determine the optimal cut-off threshold of total ritodrine hydrochloride dose to predict the incidence of pulmonary oedema in twin pregnancy based on obstetric records...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29288079/17-18-epete-gpr40-axis-ameliorates-contact-hypersensitivity-by-inhibiting-neutrophil-mobility-in-mice-and-cynomolgus-macaques
#18
Takahiro Nagatake, Yumiko Shiogama, Asuka Inoue, Junichi Kikuta, Tetsuya Honda, Prabha Tiwari, Takayuki Kishi, Atsushi Yanagisawa, Yosuke Isobe, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Hidehiko Suzuki, Soichiro Hirata, Pär Steneberg, Helena Edlund, Junken Aoki, Makoto Arita, Hiroshi Kiyono, Yasuhiro Yasutomi, Masaru Ishii, Kenji Kabashima, Jun Kunisawa
BACKGROUND: Metabolites of eicosapentaenoic acid (EPA) exert various physiological actions. 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) is a recently identified new class of anti-allergic and anti-inflammatory lipid metabolite of EPA, but its effects on skin inflammation and the underlying mechanisms remain to be investigated. OBJECTIVE: We evaluated the effectiveness of 17,18-EpETE for the control of contact hypersensitivity in mouse and cynomolgus macaques...
December 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29282581/cumulative-culture-in-nonhumans-overlooked-findings-from-japanese-monkeys
#19
REVIEW
Daniel P Schofield, William C McGrew, Akiko Takahashi, Satoshi Hirata
Cumulative culture, generally known as the increasing complexity or efficiency of cultural behaviors additively transmitted over successive generations, has been emphasized as a hallmark of human evolution. Recently, reviews of candidates for cumulative culture in nonhuman species have claimed that only humans have cumulative culture. Here, we aim to scrutinize this claim, using current criteria for cumulative culture to re-evaluate overlooked qualitative but longitudinal data from a nonhuman primate, the Japanese monkey (Macaca fuscata)...
December 27, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/29281739/lower-temperatures-reduce-type-i-interferon-activity-and-promote-alphaviral-arthritis
#20
Natalie A Prow, Bing Tang, Joy Gardner, Thuy T Le, Adam Taylor, Yee S Poo, Eri Nakayama, Thiago D C Hirata, Helder I Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A Schroder, William Klimstra, Andreas Suhrbier
Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain type I interferon responses are promoted when feet are slightly warmer...
December 27, 2017: PLoS Pathogens
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