keyword
MENU ▼
Read by QxMD icon Read
search

Hirata syndrome

keyword
https://www.readbyqxmd.com/read/29902700/ticagrelor-a-p2y12-antagonist-attenuates-vascular-dysfunction-and-inhibits-atherogenesis-in-apolipoprotein-e-deficient-mice
#1
Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Sachiko Nishimoto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Masataka Sata
BACKGROUND AND AIMS: Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe-/- ) mice. METHODS: Eight-week-old male apoe-/- mice were fed a western-type diet (WTD) supplemented with 0...
May 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29848614/impact-of-pathogenic-fbn1-variant-types-on-the-progression-of-aortic-disease-in-patients-with-marfan-syndrome
#2
Norifumi Takeda, Ryo Inuzuka, Sonoko Maemura, Hiroyuki Morita, Kan Nawata, Daishi Fujita, Yuki Taniguchi, Haruo Yamauchi, Hiroki Yagi, Masayoshi Kato, Hiroshi Nishimura, Yoichiro Hirata, Yuichi Ikeda, Hidetoshi Kumagai, Eisuke Amiya, Hironori Hara, Takayuki Fujiwara, Hiroshi Akazawa, Jun-Ichi Suzuki, Yasushi Imai, Ryozo Nagai, Shinichi Takamoto, Yasunobu Hirata, Minoru Ono, Issei Komuro
BACKGROUND: Marfan syndrome can cause life-threatening aortic complications. We investigated the relationship between FBN1 genotype and severe aortopathy (aortic root replacement, type A dissections, and related death). METHODS: We evaluated 248 patients with pathogenic or likely pathogenic FBN1 variants. The variants were classified as haploinsufficient type (HI, n=93) or dominant-negative type (DN, n=155) based on their location and predicted amino acid alterations, and we examined the effects of the FBN1 genotype on severe aortic events (aortic root replacement, type A dissections, and related death)...
June 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29846413/relationship-between-circulating-vcam-1-icam-1-e-selectin-and-mmp9-and-the-extent-of-coronary-lesions
#3
Jéssica Cavalcante Dos Santos, Marina Sampaio Cruz, Raul Hernandes Bortolin, Katiene Macêdo de Oliveira, Jéssica Nayara Góes de Araújo, Victor Hugo Rezende Duarte, Ananília Medeiros Gomes da Silva, Isabelle Cristina Clemente Dos Santos, Juliana Marinho de Oliveira Dantas, Maria Sanali Moura de Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, André Ducati Luchessi, Vivian Nogueira Silbiger
OBJECTIVES: Inflammatory molecules play a role in the development of atherosclerosis, which is the primary origin of cardiovascular disorders. However, to the best of our knowledge, no study has attempted to investigate the relationship between these circulating molecules and the prediction of cardiovascular risk. The present study aimed to investigate the relationships of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and matrix metalloproteinase 9 serum concentrations with the extent of coronary lesions...
2018: Clinics
https://www.readbyqxmd.com/read/29731400/treatment-of-infantile-spasms-by-pediatric-neurologists-in-japan
#4
Shin-Ichiro Hamano, Toshisaburo Nagai, Ryuki Matsuura, Yuko Hirata, Satoru Ikemoto, Atsuko Oba, Erika Hiwatari
OBJECTIVE: To clarify changes in clinical practice for infantile spasms, including West syndrome, in Japan over the past two decades. METHODS: We investigated common treatment strategies for infantile spasms among 157 pediatric neurologists from a designated training facility for pediatric neurology and/or a designated training facility for epilepsy in Japan. A questionnaire was used to investigate use of adrenocorticotropic hormone (ACTH) therapy including daily dose, treatment duration, and tapering off period, and preferred first to fifth-line treatment choices...
May 3, 2018: Brain & Development
https://www.readbyqxmd.com/read/29731189/potent-effect-of-prasugrel-on-acute-phase-resolution-of-intra-stent-athero-thrombotic-burden-after-percutaneous-intervention-to-acute-coronary-syndrome
#5
Yoshiro Tsukiyama, Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Yoichi Kijima, Tomoya Masano, Ryoji Nagoshi, Hiroyuki Shibata, Ryo Takeshige, Ken-Ichi Yanaka, Junya Shite, Ken-Ichi Hirata
BACKGROUND: Recent studies suggested protruding thrombus and atheroma after stent placement could be a substrate for subsequent adverse ischemic events. Although protruded atherothrombotic burden can be assessed as intra-stent tissue (IST) by optical coherence tomography (OCT), the effects of potent antiplatelet therapy on the acute phase resolution of IST in patients with acute coronary syndrome (ACS) was unknown. METHODS: Ninety-six consecutive ACS patients with multi-vessel disease were enrolled in this prospective registry...
May 3, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29720407/diagnostic-potential-of-stored-dried-blood-spots-for-inborn-errors-of-metabolism-a-metabolic-autopsy-of-medium-chain-acyl-coa-dehydrogenase-deficiency
#6
Noriyuki Kaku, Kenji Ihara, Yuichiro Hirata, Kenji Yamada, Sooyoung Lee, Hikaru Kanemasa, Yoshitomo Motomura, Haruhisa Baba, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara, Shouichi Ohga
AIM: It is estimated that 1-5% of sudden infant death syndrome (SIDS) cases might be caused by undiagnosed inborn errors of metabolism (IEMs); however, the postmortem identification of IEMs remains difficult. This study aimed to evaluate the usefulness of dried blood spots (DBSs) stored after newborn screening tests as a metabolic autopsy to determine the causes of death in infants and children who died suddenly and unexpectedly. METHODS: Infants or toddlers who had suddenly died without a definite diagnosis between July 2008 and December 2012 at Kyushu University Hospital in Japan were enrolled in this study...
May 2, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29704815/thoracic-endometriosis-syndrome-comparison-between-catamenial-pneumothorax-or-endometriosis-related-pneumothorax-and-catamenial-hemoptysis
#7
Shinya Fukuda, Tetsuya Hirata, Kazuaki Neriishi, Akari Nakazawa, Masashi Takamura, Gentaro Izumi, Miyuki Harada, Yasushi Hirota, Kaori Koga, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
OBJECTIVES: To evaluate the clinical features of thoracic endometriosis syndrome (TES) represented by catamenial pneumothorax (CP), endometriosis-related pneumothorax (ERP), and catamenial hemoptysis (CH). STUDY DESIGN: In this retrospective study, we enrolled 25 patients with TES, 18 of whom had CP/ERP and 7 had CH, to investigate the clinical presentation, effectiveness of treatment, and recurrence rates in these disorders. RESULTS: The age at onset was significantly lower in patients with CH than in patients with CP/ERP (P < 0...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29685815/safety-and-efficacy-of-eculizumab-in-guillain-barr%C3%A3-syndrome-a-multicentre-double-blind-randomised-phase-2-trial
#8
Sonoko Misawa, Satoshi Kuwabara, Yasunori Sato, Nobuko Yamaguchi, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Tadashi Kanouchi, Nobuo Kohara, Michi Kawamoto, Junko Ishii, Motoi Kuwahara, Hidekazu Suzuki, Koichi Hirata, Norito Kokubun, Ray Masuda, Juntaro Kaneko, Ichiro Yabe, Hidenao Sasaki, Ken-Ichi Kaida, Hiroshi Takazaki, Norihiro Suzuki, Shigeaki Suzuki, Hiroyuki Nodera, Naoko Matsui, Shoji Tsuji, Haruki Koike, Ryo Yamasaki, Susumu Kusunoki
BACKGROUND: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. METHODS: This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan...
June 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29682388/granulomatosis-with-polyangiitis-localized-in-the-greater-omentum
#9
Ryuji Komine, Takashi Kobayashi, Hiro Uehara, Keisuke Minamimura, Kazuhiko Mori, Toru Hirata, Atsushi Shimizu, Masaya Mori
Granulomatosis with polyangiitis (GPA) is known as anti-neutrophil cytoplasmic antibody- (ANCA-) associated small vessel vasculitis and typically manifests as pulmonary-renal syndrome, but the disease is not limited to pulmonary or renal systems. The inflammation can involve whole body organs. In addition, the ANCA titer does not always become positive. Here, we describe the case of a 91-year-old man who presented with umbilical pain and fever of unknown origin. Only the increased computed tomography value of the greater omentum suggested intra-abdominal inflammation; however, serological examinations, including the ANCA level, could not reveal the focus or cause of symptoms...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29682213/pharmacogenetics-based-area-under-curve-model-can-predict-efficacy-and-adverse-events-from-axitinib-in-individual-patients-with-advanced-renal-cell-carcinoma
#10
Yoshiaki Yamamoto, Ryouichi Tsunedomi, Yusuke Fujita, Toru Otori, Mitsuyoshi Ohba, Yoshihisa Kawai, Hiroshi Hirata, Hiroaki Matsumoto, Jun Haginaka, Shigeo Suzuki, Rajvir Dahiya, Yoshihiko Hamamoto, Kenji Matsuyama, Shoichi Hazama, Hiroaki Nagano, Hideyasu Matsuyama
We investigated the relationship between axitinib pharmacogenetics and clinical efficacy/adverse events in advanced renal cell carcinoma (RCC) and established a model to predict clinical efficacy and adverse events using pharmacokinetic and gene polymorphisms related to drug metabolism and efflux in a phase II trial. We prospectively evaluated the area under the plasma concentration-time curve (AUC) of axitinib, objective response rate, and adverse events in 44 consecutive advanced RCC patients treated with axitinib...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29610114/two-cases-of-unidentified-acute-compartment-syndrome
#11
Shinsuke Takeda, Masahiro Tatebe, Atsushi Sakai, Hitoshi Hirata
Acute compartment syndrome (ACS) is a surgical emergency that requires urgent fasciotomy to prevent irreversible sequelae. We report two cases of unidentified ACS, which did not result from traumatic injuries such as fractures or crush injury, iatrogenic injury or diseases such as haematological malignancies. Both patients complained of severe pain and swelling of their extremity. No bite marks, blisters or skin necrosis was noted. They also complained of marked symptoms of third cranial nerve injury, including divergent squint and diplopia...
April 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29602897/accelerated-cardiomyocyte-proliferation-in-the-heart-of-a-neonate-with-leopard-syndrome-associated-fatal-cardiomyopathy
#12
Yu Nakagama, Ryo Inuzuka, Kayoko Ichimura, Munetoshi Hinata, Hiroki Takehara, Norihiko Takeda, Satsuki Kakiuchi, Kazuhiro Shiraga, Hiroko Asakai, Takahiro Shindo, Yoichiro Hirata, Makiko Saitoh, Akira Oka
No abstract text is available yet for this article.
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29574523/alcohol-consumption-and-early-onset-risk-of-colorectal-cancer-in-japanese-patients-with-lynch-syndrome-a-cross-sectional-study-conducted-by-the-japanese-society-for-cancer-of-the-colon-and-rectum
#13
Masashi Miguchi, Takao Hinoi, Kohji Tanakaya, Tatsuro Yamaguchi, Yoichi Furukawa, Teruhiko Yoshida, Kazuo Tamura, Kokichi Sugano, Chikashi Ishioka, Nagahide Matsubara, Naohiro Tomita, Masami Arai, Hideki Ishikawa, Keiji Hirata, Yoshihisa Saida, Hideyuki Ishida, Kenichi Sugihara
We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history...
March 24, 2018: Surgery Today
https://www.readbyqxmd.com/read/29572511/double-deletion-of-tetraspanins-cd9-and-cd81-in-mice-leads-to-a-syndrome-resembling-accelerated-aging
#14
Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogoh
Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and atrophy of various organs, including thymus, muscle, and testis, resulting in shorter survival than wild-type (WT) mice...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425580/japanese-sleep-questionnaire-for-elementary-schoolers-jsq-es-validation-and-population-based-score-distribution
#15
Ayano Kuwada, Ikuko Mohri, Ryosuke Asano, Shigeyuki Matsuzawa, Kumi Kato-Nishimura, Ikuko Hirata, Takashi Mitsuhosi, Kuriko Kagitani-Shimono, Mariko Nakanishi, Masaya Tachibana, Yuko Ohno, Masako Taniike
OBJECTIVE: The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances of Japanese children. The current study aimed to present psychometric properties and describe the score distribution of the JSQ-ES. In addition, it examined correlations between the sleep and daytime behavior of school-aged children. METHOD: Guardians of 4369 elementary school children and 100 children diagnosed with sleep disorders in two clinics completed the JSQ-ES...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29409370/clinical-practice-guideline-for-sj%C3%A3-gren-s-syndrome-2017
#16
Takayuki Sumida, Naoto Azuma, Masafumi Moriyama, Hiroyuki Takahashi, Hiromitsu Asashima, Fumika Honda, Saori Abe, Yuko Ono, Tomoya Hirota, Shintaro Hirata, Yoshiya Tanaka, Toshimasa Shimizu, Hideki Nakamura, Atsushi Kawakami, Hajime Sano, Yoko Ogawa, Kazuo Tsubota, Koufuchi Ryo, Ichiro Saito, Akihiko Tanaka, Seiji Nakamura, Etsuko Takamura, Masao Tanaka, Katsuya Suzuki, Tsutomu Takeuchi, Noriyuki Yamakawa, Tsuneyo Mimori, Akiko Ohta, Susumu Nishiyama, Toshio Yoshihara, Yasunori Suzuki, Mitsuhiro Kawano, Minako Tomiita, Hiroto Tsuboi
OBJECTIVES: The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS: The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the Ministry of Health, Labor and Welfare (MHLW), Japan. The committee completed a systematic review of evidences for several clinical questions and developed CPG for SS 2017 according to the procedure proposed by the Medical Information Network Distribution Service (Minds)...
March 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29321405/reversible-parkinsonism-and-multiple-cerebral-infarctions-after-pulmonary-endarterectomy-in-a-patient-with-antiphospholipid-syndrome
#17
Mitsumasa Okano, Kazuhiko Nakayama, Naoki Tamada, Yuto Shinkura, Ken-Ichi Yanaka, Hiroyuki Onishi, Hidekazu Tanaka, Toshiro Shinke, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Ken-Ichi Hirata
Antiphospholipid syndrome (APS) is a cause of chronic thromboembolic pulmonary hypertension (CTEPH) and it is associated with an increased risk of postoperative neurological complications. We experienced a case of reversible parkinsonism after pulmonary endarterectomy (PEA) and subsequent multiple cerebral infarctions under standard anticoagulation therapy in a patient with CTEPH associated with APS. Strict management using a combination of antiplatelet and anticoagulation therapy should be considered in patients with a high titer of triple antiphospholipid antibodies in the perioperative period...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29276674/upfront-triple-combination-therapy-induced-pulmonary-edema-in-a-case-of-pulmonary-arterial-hypertension-associated-with-sjogren-s-syndrome
#18
Kimikazu Takeuchi, Kazuhiko Nakayama, Mitsumasa Okano, Naoki Tamada, Hideya Suehiro, Yuto Shinkura, Kenichi Yanaka, Hiroyuki Onishi, Hidekazu Tanaka, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
Clinical efficacy of combination therapy using vasodilators for pulmonary arterial hypertension (PAH) is well established. However, information on its safety are limited. We experienced a case of primary Sjogren's syndrome associated with PAH where the patient developed pulmonary edema immediately after the introduction of upfront triple combination therapy. Although the combination therapy successfully stabilized her pre-shock state, multiple ground glass opacities (GGO) emerged. We aborted the dose escalation of epoprostenol and initiated continuous furosemide infusion and noninvasive positive pressure ventilation (NPPV), but this did not prevent an exacerbation of pulmonary edema...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29249525/barth-syndrome-different-approaches-to-diagnosis
#19
Atsuko Imai-Okazaki, Yoshihito Kishita, Masakazu Kohda, Yukiko Yatsuka, Tomoko Hirata, Yosuke Mizuno, Hiroko Harashima, Keiichi Hirono, Fukiko Ichida, Atsuko Noguchi, Masayuki Yoshida, Chiho Tokorodani, Ritsuo Nishiuchi, Atsuhito Takeda, Akihiro Nakaya, Yasushi Sakata, Kei Murayama, Akira Ohtake, Yasushi Okazaki
The diagnosis of Barth syndrome is challenging owing to the wide phenotypic spectrum with allelic heterogeneity. Here we report 3 cases of Barth syndrome with phenotypic and allelic heterogeneity that were diagnosed by different approaches, including whole exome sequencing and final confirmation by reverse-transcription polymease chain reaction.
February 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29082550/reversed-rivero-carvallo-s-sign-confirmed-by-blood-flow-analysis-using-cardiac-magnetic-resonance-imaging-in-a-patient-with-straight-back-syndrome
#20
Makiko Suto, Shumpei Mori, Tatsuya Nishii, Yu Izawa, Shinsuke Shimoyama, Hiroki Konishi, Kensuke Matsumoto, Hidekazu Tanaka, Ken-Ichi Hirata
An asymptomatic 45-year-old man was referred to our hospital for detailed evaluation of a systolic ejection murmur. The intensity of the murmur increased on deep expiration and decreased on deep inspiration, showing so-called reversed Rivero-Carvallo's sign. Using cardiac magnetic resonance imaging, we demonstrated a characteristic respiratory-induced change in peak flow velocity in the right ventricular outflow tract, which was the basic mechanism of the reversed Rivero-Carvallo's sign in a case with straight back syndrome...
November 2017: Echocardiography
keyword
keyword
114358
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"