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Hirata syndrome

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https://www.readbyqxmd.com/read/27862978/abcc3-polymorphisms-and-mrna-expression-influence-the-concentration-of-a-carboxylic-acid-metabolite-in-patients-on-clopidogrel-and-aspirin-therapy
#1
André Ducati Luchessi, Marta Concheiro, Juliana de Freitas Germano, Vivian Nogueira Silbiger, Raul Hernandes Bortolin, Angelines Cruz, Oscar Quintela, Maria Brion, Angel Carracedo, Andres Iñiguez, Marisol Bravo, Manuel López-Rivadulla, Rosario Dominguez Crespo Hirata, Amanda Guerra Moraes Rego Sousa, Mario Hiroyuki Hirata
Acetylsalicylic acid and clopidogrel combined therapy has been reported to be beneficial in patients with acute coronary syndrome (ACS). Antiplatelet drug resistance, especially to clopidogrel, is a multifactorial phenomenon that affects a large number of ACS patients. The genetic contribution to this drug response is not fully elucidated. We investigated the relationship of ABC-type efflux subfamily C member 3 (ABCC3) polymorphisms and mRNA expression with plasma concentrations of clopidogrel, salicylic acid (SA), and a carboxylic acid metabolite (CAM)...
November 12, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27853069/compression-of-the-right-ventricular-outflow-tract-due-to-straight-back-syndrome-clarified-by-low-dose-dual-source-computed-tomography
#2
Kohei Hasegawa, Tomofumi Takaya, Shumpei Mori, Tatsuro Ito, Sei Fujiwara, Tatsuya Nishii, Atsushi K Kono, Hiroyuki Shimoura, Hidekazu Tanaka, Ken-Ichi Hirata
A 23-year-old asymptomatic woman was referred to our hospital for further examination of a systolic ejection murmur with fixed splitting of the second heart sound auscultated at the third left sternal border. Initial echocardiography could not detect the cause. Subsequently performed low-dose computed tomography, however, ruled out the possibility of any congenital heart diseases, but revealed a markedly shortened anteroposterior diameter of the chest, which led us to a diagnosis of straight back syndrome. A vertically oriented "pancake" appearance of the heart, straight vertebral column, and compression of the right ventricular outflow tract were clearly demonstrated on the reconstructed images...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27829590/results-of-a-prospective-study-of-acute-coronary-syndrome-hospitalization-after-enactment-of-a-smoking-ban-in-public-places-in-hyogo-prefecture%C3%A3-comparison-with-gifu-a-prefecture-without-a-public-smoking-ban
#3
Yukihito Sato, Shinya Minatoguchi, Kazuhiko Nishigaki, Ken-Ichi Hirata, Tohru Masuyama, Yutaka Furukawa, Masaaki Uematsu, Junichi Yoshikawa, Satoru Otsuji, Mami Iida, Hisayoshi Fujiwara
BACKGROUND: Hyogo Prefecture is the 2nd prefecture in Japan, after Kanagawa, to enact a ban with penal code on smoking in public places, although the restriction is partial.Methods and Results:This study included consecutive patients with acute coronary syndrome (ACS) who were admitted to 33 major hospitals in the Hyogo District during the 12 months before implementation of the legislation and during the 24 months thereafter. Consecutive patients with ACS from Gifu Prefecture who were admitted to 20 major hospitals were enrolled as geographical controls...
November 10, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27821382/a-prospective-multicenter-randomized-phase-ii-study-to-evaluate-the-efficacy-and-safety-of-eculizumab-in-patients-with-guillain-barr%C3%A3-syndrome-gbs-protocol-of-japanese-eculizumab-trial-for-gbs-jet-gbs
#4
Nobuko Yamaguchi, Sonoko Misawa, Yasunori Sato, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Nobuo Kohara, Koichi Hirata, Kazutoshi Nishiyama, Ichiro Yabe, Ken-Ichi Kaida, Norihiro Suzuki, Hiroyuki Nodera, Shoji Tsuji, Haruki Koike, Jun-Ichi Kira, Hideki Hanaoka, Susumu Kusunoki, Satoshi Kuwabara
BACKGROUND: Guillain-Barré syndrome (GBS) is an immune-mediated neuropathy that causes acute flaccid paralysis. Immunoglobulin and plasma exchange are established treatments for GBS; however, a substantial number of patients, particularly those with severe disease, have poor recovery and residual deficits. Recent studies suggest that complement activation plays a pivotal role in GBS-associated axonal degeneration, and eculizumab is a humanized monoclonal antibody that specifically binds to complement component 5 and potently inhibits complement activation...
November 7, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27821298/anterior-interosseous-nerve-and-posterior-interosseous-nerve-involvement-in-neuralgic-amyotrophy
#5
Mao Akane, Katsuyuki Iwatsuki, Masahiro Tatebe, Takanobu Nishizuka, Shigeru Kurimoto, Michiro Yamamoto, Hitoshi Hirata
OBJECTIVES: The aim of this study was to gain a better understanding of anterior interosseous nerve and posterior interosseous nerve involvement in neuralgic amyotrophy. METHODS: In a retrospective chart review, 51 cases (49 patients) with anterior and posterior interosseous nerve syndrome were investigated in terms of their symptoms, course of disease, and prognosis. RESULTS: Patients first presented with pain in 52.9% of cases. The location of the pain was distal to the shoulder in most cases (85...
December 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27812167/usefulness-of-cardiac-mibg-scintigraphy-olfactory-testing-and-substantia-nigra-hyperechogenicity-as-additional-diagnostic-markers-for-distinguishing-between-parkinson-s-disease-and-atypical-parkinsonian-syndromes
#6
Hiroaki Fujita, Keisuke Suzuki, Ayaka Numao, Yuji Watanabe, Tomoyuki Uchiyama, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata
BACKGROUND: We aimed to evaluate the utility of the combined use of cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, olfactory testing, and substantia nigra (SN) hyperechogenicity on transcranial sonography (TCS) in differentiating Parkinson's disease (PD) from atypical parkinsonian syndromes (APSs), such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). METHODS: Cardiac MIBG scintigraphy, card-type odor identification testing (Open Essence (OE), Wako, Japan), and TCS were performed with 101 patients with PD and 38 patients with APSs (MSA and PSP)...
2016: PloS One
https://www.readbyqxmd.com/read/27804246/polymyxin-b-immobilized-column-direct-hemoperfusion-for-adolescent-toxic-shock-syndrome
#7
Etsuro Nanishi, Yuichirou Hirata, Sooyoung Lee, Noriyuki Kaku, Kenta Momii, Kensuke Kubota, Hisanori Nishio, Yoshihiko Maehara, Toshiro Hara
Toxic shock syndrome (TSS) is a critical illness associated with toxin from Staphylococcus aureus. Despite recent advances in critical care, mortality remains high and additional effective therapy is required. We report an adolescent case of TSS successfully treated with direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP). The patient with spina bifida also had ischial pressure ulcer, and developed TSS associated with methicillin-resistant S. aureus. Despite conventional treatment, the patient developed refractory shock, which was immediately improved with PMX-DHP...
October 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27682649/autoantibody-to-scaffold-attachment-factor-b-safb-a-novel-connective-tissue-disease-related-autoantibody-associated-with-interstitial-lung-disease
#8
Akiko Takeuchi, Takashi Matsushita, Kenzo Kaji, Yoshinobu Okamoto, Masahide Yasui, Masayoshi Hirata, Naoto Oishi, Akira Higashi, Mariko Seishima, Tomoya Asano, Manabu Fujimoto, Masataka Kuwana, Kazuhiko Takehara, Yasuhito Hamaguchi
OBJECTIVE: To identify and characterize a novel connective tissue disease (CTD)-related autoantibody (autoAb) directed against scaffold attachment factor B (SAFB). METHODS: AutoAb specificity was analyzed using RNA and protein-immunoprecipitation assays. Autoimmune targets were affinity purified using patients' sera and subjected to liquid chromatography mass spectrometry. RESULTS: By immunoprecipitation assay, 10 sera reacted with a protein with a molecular weight of approximately 160 kDa...
September 24, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27650915/bidirectional-approach-of-video-assisted-neck-surgery-bavans-endoscopic-complete-central-node-dissection-with-craniocaudal-view-for-treatment-of-thyroid-cancer
#9
Akihiro Nakajo, Hideo Arima, Munetsugu Hirata, Yoshie Yamashita, Yoshiaki Shinden, Naoki Hayashi, Yota Kawasaki, Takaaki Arigami, Yasuto Uchikado, Shinichiro Mori, Yuko Mataki, Masahiko Sakoda, Yuko Kijima, Yoshikazu Uenosono, Kosei Maemura, Shoji Natsugoe
INTRODUCTION: Endoscopic thyroidectomy is a well-established surgical technique that is mainly performed for benign thyroid disease. We considered that endoscopic surgery could also be widely indicated for the treatment of thyroid cancer. We herein describe our new bidirectional approach of video-assisted neck surgery (BAVANS) for complete central node dissection in endoscopic thyroid cancer surgery. METHODS: BAVANS involves two different directional pathways to the cervical lesion...
September 21, 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27629973/restless-bladder-in-an-elderly-woman-an-unusual-feature-or-a-variant-of-restless-legs-syndrome
#10
Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Uchiyama, Tomoyuki Miyamoto, Takeo Matsubara, Koichi Hirata
We herein report an elderly patient with a history of restless legs syndrome (RLS) who developed unpleasant sensations in the lower abdomen and perineum. The patient' s symptoms occurred during the evening and at rest and forced the patient to void, resulting in some symptom relief. Urological examinations and spinal magnetic resonance imaging findings were unremarkable. The adjunctive use of rotigotine resolved her symptoms. The symptoms were considered to be "restless bladder". Further studies are required to elucidate whether restless bladder is an identical condition to the clinical entities of other RLS variants or whether it represents an unusual feature of RLS...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27590373/a-prospective-pilot-study-of-fetoscopic-laser-surgery-for-twin-to-twin-transfusion-syndrome-between-26-and-27-weeks-of-gestation
#11
Masahiko Nakata, Keisuke Ishii, Masahiro Sumie, Mayumi Takano, Hiroko Hirata, Susumu Murata, Yuichiro Takahashi, Takeshi Murakoshi, Haruhiko Sago
OBJECTIVE: The aim of this study is to clarify the feasibility and efficacy of fetoscopic laser photocoagulation of placental vascular communicating vessels (FLP) on twin-twin transfusion syndrome (TTTS) after 26 weeks of gestation. MATERIALS AND METHODS: This is a prospective pilot study investigating all cases of TTTS between 26 weeks and 27 weeks during 2012 and 2013 in Japan. The primary endpoints in this study were the feasibility of FLP and rate of harmful complications for the mother's health...
August 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27588366/diagnosis-of-insulin-autoimmune-syndrome-using-polyethylene-glycol-precipitation-and-gel-filtration-chromatography-with-ex-vivo-insulin-exchange
#12
David Church, Luís Cardoso, Sonia Bradbury, Catriona Clarke, Anna Stears, Anna Dover, David Halsall, Robert Semple
CONTEXT: Insulin-binding antibodies may produce severe dysglycaemia in insulin-naïve patients ('insulin autoimmune syndrome' (IAS) or Hirata disease), while rendering routine insulin assays unreliable. OBJECTIVE: To assess the performance of clinically used insulin assays and an optimal analytical approach in the context of IAS. DESIGN: Observational biochemical study of selected patients with hyperinsulinaemic hypoglycaemia. PATIENTS: Three patients without diabetes with recurrent spontaneous hyperinsulinaemic hypoglycaemia and 'positive' insulin antibodies...
September 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27586541/the-relationship-of-the-oleic-acid-level-and-echdc3-mrna-expression-with-the-extent-of-coronary-lesion
#13
Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Victor Hugo Rezende Duarte, Katiene Macêdo de Oliveira, Juliana Marinho de Oliveira, Antonio Augusto Ferreira Carioca, Raul Hernandes Bortolin, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosário Domingues Hirata, Dan Linetzky Waitzberg, Severina Carla Vieira Cunha Lima, André Ducati Luchessi, Vivian Nogueira Silbiger
BACKGROUND: The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion. METHODS: Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27582323/early-therapeutic-intervention-for-crush-syndrome-characterization-of-intramuscular-administration-of-dexamethasone-by-pharmacokinetic-and-biochemical-parameters-in-rats
#14
Isamu Murata, Mai Goto, Masahiro Komiya, Risa Motohashi, Momoko Hirata, Yutaka Inoue, Ikuo Kanamoto
Crush syndrome (CS) is the systemic manifestation of muscle cell damage resulting from pressure and crushing. It is associated with a high mortality rate, even when patients are treated with conventional therapy. We demonstrated the utility of intramuscular administration of dexamethasone (DEX) in disaster medical care by using a model of CS to characterize the pharmacokinetics and biochemical parameters. We compared intravenous (IV) and intramuscular (IM) injection. The IM sites were the right anterior limb (AL), bilateral hind limbs (bHL), and unilateral hind limb (uHL)...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27578910/carpal-tunnel-syndrome-associated-with-kienb%C3%A3-ck-disease
#15
Takaaki Shinohara, Ryogo Nakamura, Etsuhiro Nakao, Hitoshi Hirata
We retrospectively reviewed 12 patients (3 men and 9 women, with a mean age of 72 years) who were surgically treated for carpal tunnel syndrome associated with Kienböck disease. All patients except 1 were incidentally diagnosed with Kienböck disease and had little or no wrist pain. Radiographic tests revealed advanced Kienböck disease in all patients. Intraoperative findings indicated that the site of maximum compression on the median nerve was located at the level of the carpal tunnel inlet in 11 patients, and the volar dislocated fragment of the lunate was located proximally adjacent to the floor of the carpal tunnel inlet...
August 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27543010/integrated-analysis-of-mirna-and-mrna-gene-expression-microarrays-influence-on-platelet-reactivity-clopidogrel-response-and-drug-induced-toxicity
#16
Renata Caroline Costa de Freitas, Raul Hernandes Bortolin, Mariana Borges Lopes, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Vivian Nogueira Silbiger, André Ducati Luchessi
Genetic and epigenetic variability may influence the efficacy and safety of antiplatelet therapies, including clopidogrel. Therefore, the miRNA-mRNA interactions and drug toxicity were investigated in silico using available microarray data. Expressions profiles of platelet miRNA (GSE59488) from acute coronary syndrome and mRNA in peripheral blood cells (GSE32226) from coronary artery disease patients were used to miRNA-target mRNA integrated analysis by Ingenuity Pathways Analysis 6 software (IPA). Results showed that ST13 mRNA is regulated by hsa-miR-107 (miR-103-3p); BTNL3 and CFD mRNAs are regulated by hsa-miR-4701-3p (miR-1262); SLC7A8 is regulated by hsa-miR-145-5p (miR-145-5p); and SENP5 mRNA is regulated by hsa-miR-15b-5p (miR-16-5p) and hsa-miR-26a-5p (miR-26a-5p)...
November 15, 2016: Gene
https://www.readbyqxmd.com/read/27538618/intravenous-immunoglobulin-therapy-is-rarely-effective-as-the-initial-treatment-in-west-syndrome-a-retrospective-study-of-70-patients
#17
Ryuki Matsuura, Shin-Ichiro Hamano, Yuko Hirata, Atsuko Oba, Kotoko Suzuki, Kenjiro Kikuchi
PURPOSE: To evaluate factors influencing the efficacy and safety of intravenous immunoglobulins (IVIG) therapy for West syndrome. METHODS: We investigated seizure outcomes in 70 patients who received IVIG treatment for West Syndrome during the first 3months after the onset of epileptic spasms. IVIG was administered for 3 consecutive days (initial IVIG treatment) at dosages ranging from 100 to 500mg/kg/day. If spasms disappeared within 2weeks of the initial treatment, maintenance IVIG treatment was commenced...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27459020/effectiveness-of-abatacept-for-patients-with-sj%C3%A3-gren-s-syndrome-associated-with-rheumatoid-arthritis-an-open-label-multicenter-one-year-prospective-study-rose-rheumatoid-arthritis-with-orencia-trial-toward-sj%C3%A3-gren-s-syndrome-endocrinopathy-trial
#18
Hiroto Tsuboi, Isao Matsumoto, Shinya Hagiwara, Tomoya Hirota, Hiroyuki Takahashi, Hiroshi Ebe, Masahiro Yokosawa, Mizuki Yagishita, Hidenori Takahashi, Izumi Kurata, Ayako Ohyama, Fumika Honda, Hiromitsu Asashima, Haruka Miki, Naoto Umeda, Yuya Kondo, Shintaro Hirata, Kazuyoshi Saito, Yoshiya Tanaka, Yoshiro Horai, Hideki Nakamura, Atsushi Kawakami, Takayuki Sumida
OBJECTIVE: To clarify the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). METHODS: The primary endpoint of this open-labeled, prospective, observational multicenter study for secondary SS with RA was the remission rate of Simplified Disease Activity Index (SDAI) at 52 weeks after initiation of abatacept. The secondary endpoints included Saxon's test and Schirmer's test. Adverse events and adherence rate during the study period were also analyzed...
July 26, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27417045/recovery-function-of-somatosensory-evoked-brain-response-in-patients-with-carpal-tunnel-syndrome-a-magnetoencephalographic-study
#19
Katsuyuki Iwatsuki, Akihito Yoshida, Takaaki Shinohara, Tomonori Nakano, Jun-Ichi Uemura, Sae Goto, Masaaki Hirayama, Minoru Hoshiyama, Hitoshi Hirata
OBJECTIVE: The recovery function of somatosensory evoked magnetic fields (SEFs) was recorded to investigate excitatory and inhibitory balance in the somatosensory cortex of patients with carpal tunnel syndrome. METHODS: SEFs were recorded in patients and controls. Recordings were taken following median nerve stimulation with single and double pulses with interstimulus intervals of 10-200ms. The root mean square for the N20m component following the second stimulation was analyzed...
August 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27403097/safety-of-regular-dose-imatinib-therapy-in-patients-with-gastrointestinal-stromal-tumors-undergoing-dialysis
#20
Ryota Niikura, Takako Serizawa, Atsuo Yamada, Shuntaro Yoshida, Mariko Tanaka, Yoshihiro Hirata, Kazuhiko Koike
The number of cancer patients undergoing dialysis has been increasing, and the number of these patients on chemotherapy is also increasing. Imatinib is an effective and safe therapy for KIT-positive gastrointestinal stromal tumors (GIST), but the efficacy and safety of imatinib in dialysis patients remain unclear. Because clinical trials have not been conducted in this population, more investigations are required. We report on a 75-year-old Japanese man undergoing dialysis who presented with massive tarry stool from a duodenal GIST...
January 2016: Case Reports in Gastroenterology
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